(The TQCC of Nature is 15. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-04-01 to 2024-04-01.)
Highly accurate protein structure prediction with AlphaFold17754
Array programming with NumPy10009
The mutational constraint spectrum quantified from variation in 141,456 humans5831
Virological assessment of hospitalized patients with COVID-20195412
Factors associated with COVID-19-related death using OpenSAFELY4425
A SARS-CoV-2 protein interaction map reveals targets for drug repurposing3243
Structure of Mpro from SARS-CoV-2 and discovery of its inhibitors2944
Estimating the effects of non-pharmaceutical interventions on COVID-19 in Europe2359
Pseudo-halide anion engineering for α-FAPbI3 perovskite solar cells2115
Perovskite solar cells with atomically coherent interlayers on SnO2 electrodes2089
Efficient perovskite solar cells via improved carrier management1989
Highly accurate protein structure prediction for the human proteome1727
Antibody resistance of SARS-CoV-2 variants B.1.351 and B.1.1.71679
SARS-CoV-2-specific T cell immunity in cases of COVID-19 and SARS, and uninfected controls1656
Convergent antibody responses to SARS-CoV-2 in convalescent individuals1631
Cross-neutralization of SARS-CoV-2 by a human monoclonal SARS-CoV antibody1628
Longitudinal analyses reveal immunological misfiring in severe COVID-191623
SARS-CoV-2 vaccines in development1595
Reduced sensitivity of SARS-CoV-2 variant Delta to antibody neutralization1539
COVID-19 vaccine BNT162b1 elicits human antibody and TH1 T cell responses1442
Aerodynamic analysis of SARS-CoV-2 in two Wuhan hospitals1363
Detection of a SARS-CoV-2 variant of concern in South Africa1343
SARS-CoV-2 neutralizing antibody structures inform therapeutic strategies1302
Potent neutralizing antibodies against multiple epitopes on SARS-CoV-2 spike1280
Evolution of antibody immunity to SARS-CoV-21273
Omicron escapes the majority of existing SARS-CoV-2 neutralizing antibodies1253
Expanded encyclopaedias of DNA elements in the human and mouse genomes1239
Human neutralizing antibodies elicited by SARS-CoV-2 infection1231
Photocatalytic water splitting with a quantum efficiency of almost unity1229
Spike mutation D614G alters SARS-CoV-2 fitness1227
A human neutralizing antibody targets the receptor-binding site of SARS-CoV-21173
Design of robust superhydrophobic surfaces1135
Phase I/II study of COVID-19 RNA vaccine BNT162b1 in adults1134
Pathogenesis and transmission of SARS-CoV-2 in golden hamsters1131
Rapid epidemic expansion of the SARS-CoV-2 Omicron variant in southern Africa1129
mRNA vaccine-elicited antibodies to SARS-CoV-2 and circulating variants1093
Towards complete and error-free genome assemblies of all vertebrate species1090
Considerable escape of SARS-CoV-2 Omicron to antibody neutralization1090
SARS-CoV-2 mRNA vaccine design enabled by prototype pathogen preparedness1078
Effects of extracellular matrix viscoelasticity on cellular behaviour1041
Designing the next generation of proton-exchange membrane fuel cells1030
SARS-CoV-2-reactive T cells in healthy donors and patients with COVID-191018
The effect of large-scale anti-contagion policies on the COVID-19 pandemic1006
Sequencing of 53,831 diverse genomes from the NHLBI TOPMed Program987
SARS-CoV-2 B.1.617.2 Delta variant replication and immune evasion962
Striking antibody evasion manifested by the Omicron variant of SARS-CoV-2958
Correlates of protection against SARS-CoV-2 in rhesus macaques949
Sex differences in immune responses that underlie COVID-19 disease outcomes935
Mapping genomic loci implicates genes and synaptic biology in schizophrenia932
Genetic mechanisms of critical illness in COVID-19928
Mobility network models of COVID-19 explain inequities and inform reopening926
High-dimensional characterization of post-acute sequelae of COVID-19922
An engineered PET depolymerase to break down and recycle plastic bottles917
Potently neutralizing and protective human antibodies against SARS-CoV-2916
Assessing transmissibility of SARS-CoV-2 lineage B.1.1.7 in England915
A molecular cell atlas of the human lung from single-cell RNA sequencing915
The changing landscape of atherosclerosis909
The pathogenicity of SARS-CoV-2 in hACE2 transgenic mice898
Structures and distributions of SARS-CoV-2 spike proteins on intact virions875
A 20-year retrospective review of global aquaculture864
Omicron extensively but incompletely escapes Pfizer BNT162b2 neutralization862
BA.2.12.1, BA.4 and BA.5 escape antibodies elicited by Omicron infection831
Cells of the adult human heart825
Reproducible brain-wide association studies require thousands of individuals824
Broadly neutralizing antibodies overcome SARS-CoV-2 Omicron antigenic shift814
Age-specific mortality and immunity patterns of SARS-CoV-2813
Accelerated discovery of CO2 electrocatalysts using active machine learning809
Effect of non-pharmaceutical interventions to contain COVID-19 in China806
A comprehensive quantification of global nitrous oxide sources and sinks800
Proteomics of SARS-CoV-2-infected host cells reveals therapy targets797
SARS-CoV-2 is associated with changes in brain structure in UK Biobank783
Papain-like protease regulates SARS-CoV-2 viral spread and innate immunity767
SARS-CoV-2 evolution during treatment of chronic infection746
Altered TMPRSS2 usage by SARS-CoV-2 Omicron impacts infectivity and fusogenicity745
Suppression of a SARS-CoV-2 outbreak in the Italian municipality of Vo’740
Fibrosis: from mechanisms to medicines739
Photocatalytic solar hydrogen production from water on a 100-m2 scale734
DHODH-mediated ferroptosis defence is a targetable vulnerability in cancer729
Parallel convolutional processing using an integrated photonic tensor core718
Developing fibrillated cellulose as a sustainable technological material717
A reference map of the human binary protein interactome716
Increased mortality in community-tested cases of SARS-CoV-2 lineage B.1.1.7709
Single-shot Ad26 vaccine protects against SARS-CoV-2 in rhesus macaques700
ChAdOx1 nCoV-19 vaccine prevents SARS-CoV-2 pneumonia in rhesus macaques699
Viral and host factors related to the clinical outcome of COVID-19684
APOE4 leads to blood–brain barrier dysfunction predicting cognitive decline681
Short-range order and its impact on the CrCoNi medium-entropy alloy679
Animal models for COVID-19679
Receptor binding and priming of the spike protein of SARS-CoV-2 for membrane fusion674
A large-scale binding and functional map of human RNA-binding proteins650
A single-cell transcriptomic atlas characterizes ageing tissues in the mouse642
A mobile robotic chemist639
Controlled growth of perovskite layers with volatile alkylammonium chlorides638
Strong tough hydrogels via the synergy of freeze-casting and salting out632
How China could be carbon neutral by mid-century630
FinnGen provides genetic insights from a well-phenotyped isolated population628
Discovery of SARS-CoV-2 antiviral drugs through large-scale compound repurposing628
NASH limits anti-tumour surveillance in immunotherapy-treated HCC621
Autophagy promotes immune evasion of pancreatic cancer by degrading MHC-I616
Antibody evasion properties of SARS-CoV-2 Omicron sublineages610
A vaccine targeting the RBD of the S protein of SARS-CoV-2 induces protective immunity604
Structure of replicating SARS-CoV-2 polymerase600
Programmable photonic circuits598
A structural variation reference for medical and population genetics598
Exploring tissue architecture using spatial transcriptomics587
ChatGPT: five priorities for research587
Accelerated global glacier mass loss in the early twenty-first century581
Pattern-recognition receptors are required for NLR-mediated plant immunity580
Naturally enhanced neutralizing breadth against SARS-CoV-2 one year after infection578
Mapping the human genetic architecture of COVID-19577
Variability in the analysis of a single neuroimaging dataset by many teams577
Population flow drives spatio-temporal distribution of COVID-19 in China572
High and rising economic costs of biological invasions worldwide570
Ultralow contact resistance between semimetal and monolayer semiconductors569
SARS-CoV-2 mRNA vaccines induce persistent human germinal centre responses565
SARS-CoV-2 Omicron variant replication in human bronchus and lung ex vivo563
Filling metal–organic framework mesopores with TiO2 for CO2 photoreduction558
BNT162b2 vaccine induces neutralizing antibodies and poly-specific T cells in humans556
Single-particle cryo-EM at atomic resolution554
Self-powered soft robot in the Mariana Trench553
Large-area display textiles integrated with functional systems553
All-perovskite tandem solar cells with improved grain surface passivation552
Promises and prospects of two-dimensional transistors551
Respiratory disease in rhesus macaques inoculated with SARS-CoV-2550
Sensitivity of SARS-CoV-2 B.1.1.7 to mRNA vaccine-elicited antibodies550
Mastering Atari, Go, chess and shogi by planning with a learned model547
Diverse functional autoantibodies in patients with COVID-19539
Rebuilding marine life538
Infection of dogs with SARS-CoV-2538
Mutual potentiation of plant immunity by cell-surface and intracellular receptors534
11 TOPS photonic convolutional accelerator for optical neural networks532
Small-molecule inhibition of METTL3 as a strategy against myeloid leukaemia531
Loss of furin cleavage site attenuates SARS-CoV-2 pathogenesis529
Isolation of SARS-CoV-2-related coronavirus from Malayan pangolins527
Age-related immune response heterogeneity to SARS-CoV-2 vaccine BNT162b2523
Brain charts for the human lifespan522
COVID-19 tissue atlases reveal SARS-CoV-2 pathology and cellular targets520
Addendum: A pneumonia outbreak associated with a new coronavirus of probable bat origin517
An RNA vaccine drives immunity in checkpoint-inhibitor-treated melanoma516
Negative feedback control of neuronal activity by microglia510
Multiple wheat genomes reveal global variation in modern breeding510
Antibody evasion by SARS-CoV-2 Omicron subvariants BA.2.12.1, BA.4 and BA.5507
Telomere-to-telomere assembly of a complete human X chromosome505
Circuits between infected macrophages and T cells in SARS-CoV-2 pneumonia504
A mouse-adapted model of SARS-CoV-2 to test COVID-19 countermeasures500
Escape of SARS-CoV-2 501Y.V2 from neutralization by convalescent plasma496
Clinical benefit of remdesivir in rhesus macaques infected with SARS-CoV-2495
Lysosome-targeting chimaeras for degradation of extracellular proteins489
Enhanced ferroelectricity in ultrathin films grown directly on silicon488
Metabolic support of tumour-infiltrating regulatory T cells by lactic acid487
Cell-programmed nutrient partitioning in the tumour microenvironment484
Lymph protects metastasizing melanoma cells from ferroptosis482
DNA of neutrophil extracellular traps promotes cancer metastasis via CCDC25480
BNT162b vaccines protect rhesus macaques from SARS-CoV-2479
Massively multiplexed nucleic acid detection with Cas13478
Senolytic CAR T cells reverse senescence-associated pathologies477
RETRACTED ARTICLE: Room-temperature superconductivity in a carbonaceous sulfur hydride477
Ligand-engineered bandgap stability in mixed-halide perovskite LEDs476
Global priority areas for ecosystem restoration471
Cross-tissue organization of the fibroblast lineage462
Zoonotic host diversity increases in human-dominated ecosystems458
Quantum phases of matter on a 256-atom programmable quantum simulator457
Leading hadronic contribution to the muon magnetic moment from lattice QCD453
Atomic-resolution protein structure determination by cryo-EM448
Surface reaction for efficient and stable inverted perovskite solar cells448
Co-designing electronics with microfluidics for more sustainable cooling446
SARS-CoV-2 Omicron virus causes attenuated disease in mice and hamsters446
Attenuated fusogenicity and pathogenicity of SARS-CoV-2 Omicron variant445
Attenuated replication and pathogenicity of SARS-CoV-2 B.1.1.529 Omicron445
Tunable strongly coupled superconductivity in magic-angle twisted trilayer graphene444
Structures of α-synuclein filaments from multiple system atrophy438
The coding capacity of SARS-CoV-2437
Bacterial metabolism of bile acids promotes generation of peripheral regulatory T cells436
Area-based conservation in the twenty-first century434
Tunable correlated states and spin-polarized phases in twisted bilayer–bilayer graphene429
Multilevel proteomics reveals host perturbations by SARS-CoV-2 and SARS-CoV422
An integrated space-to-ground quantum communication network over 4,600 kilometres419
Reprogramming to recover youthful epigenetic information and restore vision418
T cell responses to SARS-CoV-2 spike cross-recognize Omicron417
Inference in artificial intelligence with deep optics and photonics417
Plasticity of ether lipids promotes ferroptosis susceptibility and evasion416
Composition-dependent thermodynamics of intracellular phase separation415
Structure-based classification of tauopathies414
Key role of chemistry versus bias in electrocatalytic oxygen evolution413
Topological polaritons and photonic magic angles in twisted α-MoO3 bilayers413
High-performance brain-to-text communication via handwriting412
SARS-CoV-2 spike D614G change enhances replication and transmission412
A bright millisecond-duration radio burst from a Galactic magnetar412
A fast radio burst associated with a Galactic magnetar411
Critical advances and future opportunities in upcycling commodity polymers411
Unextractable fossil fuels in a 1.5 °C world408
In vivo CRISPR base editing of PCSK9 durably lowers cholesterol in primates406
A bacterial cytidine deaminase toxin enables CRISPR-free mitochondrial base editing403
Satellite imaging reveals increased proportion of population exposed to floods402
Homeostatic mini-intestines through scaffold-guided organoid morphogenesis401
The major genetic risk factor for severe COVID-19 is inherited from Neanderthals401
SARS-CoV-2 infection induces long-lived bone marrow plasma cells in humans399
Heavily mutated Omicron variant puts scientists on alert398
Enhanced fusogenicity and pathogenicity of SARS-CoV-2 Delta P681R mutation398
A molecular single-cell lung atlas of lethal COVID-19397
A biomimetic eye with a hemispherical perovskite nanowire array retina394
A perspective on potential antibody-dependent enhancement of SARS-CoV-2394
The online competition between pro- and anti-vaccination views391
Machine learning-aided engineering of hydrolases for PET depolymerization391
The future of food from the sea389
In situ Raman spectroscopy reveals the structure and dissociation of interfacial water389
Bending the curve of terrestrial biodiversity needs an integrated strategy386
Tunable spin-polarized correlated states in twisted double bilayer graphene384
Stable room-temperature continuous-wave lasing in quasi-2D perovskite films384
High-resolution X-ray luminescence extension imaging381
Efficient and stable blue quantum dot light-emitting diode381
Decoding myofibroblast origins in human kidney fibrosis380
A dynamic stability design strategy for lithium metal solid state batteries379
Swarm Learning for decentralized and confidential clinical machine learning378
Exome sequencing and analysis of 454,787 UK Biobank participants377
Dysregulation of brain and choroid plexus cell types in severe COVID-19376
Association of COVID-19 inflammation with activation of the C5a–C5aR1 axis373
Identification of SARS-CoV-2 inhibitors using lung and colonic organoids373
Decade-long leukaemia remissions with persistence of CD4+ CAR T cells371
COVID-19 treatments and pathogenesis including anosmia in K18-hACE2 mice369
Inherited causes of clonal haematopoiesis in 97,691 whole genomes368
Mechanisms and therapeutic implications of hypermutation in gliomas366
Distribution control enables efficient reduced-dimensional perovskite LEDs361
Shifting attention to accuracy can reduce misinformation online361
Bayesian reaction optimization as a tool for chemical synthesis361
Activity of convalescent and vaccine serum against SARS-CoV-2 Omicron360
SARS-CoV-2 RBD antibodies that maximize breadth and resistance to escape360
Amazonia as a carbon source linked to deforestation and climate change360
The projected timing of abrupt ecological disruption from climate change359
An aged immune system drives senescence and ageing of solid organs358
Comparative cellular analysis of motor cortex in human, marmoset and mouse356
Climate change increases cross-species viral transmission risk353
Half a century of global decline in oceanic sharks and rays352
Closed-loop recycling of polyethylene-like materials351
The race for coronavirus vaccines: a graphical guide349
Sources of particulate-matter air pollution and its oxidative potential in Europe349
Exome sequencing and characterization of 49,960 individuals in the UK Biobank348
Entanglement-based secure quantum cryptography over 1,120 kilometres347
Chloroquine does not inhibit infection of human lung cells with SARS-CoV-2347
NINJ1 mediates plasma membrane rupture during lytic cell death345
Clonally expanded B cells in multiple sclerosis bind EBV EBNA1 and GlialCAM343
Rapid reconstruction of SARS-CoV-2 using a synthetic genomics platform342
Reconstruction of the full transmission dynamics of COVID-19 in Wuhan342
‘It will change everything’: DeepMind’s AI makes gigantic leap in solving protein structures340
Global human-made mass exceeds all living biomass339
A census of baryons in the Universe from localized fast radio bursts338
The central role of DNA damage in the ageing process338
Direct observation of chemical short-range order in a medium-entropy alloy337
The power of genetic diversity in genome-wide association studies of lipids337
The KEYNOTE-811 trial of dual PD-1 and HER2 blockade in HER2-positive gastric cancer337