(The TQCC of Nature is 27. The table below lists those papers that are above that threshold based on CrossRef citation counts. The publications cover those that have been published in the past four years, i.e., from 2019-03-01 to 2023-03-01.)
Ghrelin is a growth-hormone-releasing acylated peptide from stomach5971
Virological assessment of hospitalized patients with COVID-20194931
Quantum supremacy using a programmable superconducting processor2840
A role for ghrelin in the central regulation of feeding2476
Evolution of Asian monsoons and phased uplift of the Himalaya–Tibetan plateau since Late Miocene times1945
Search-and-replace genome editing without double-strand breaks or donor DNA1863
Efficient, stable and scalable perovskite solar cells using poly(3-hexylthiophene)1570
The single-cell transcriptional landscape of mammalian organogenesis1501
Next-generation characterization of the Cancer Cell Line Encyclopedia1495
Scientists rise up against statistical significance1450
Deep learning and process understanding for data-driven Earth system science1387
Multi-omics of the gut microbial ecosystem in inflammatory bowel diseases1151
Single-cell transcriptomic analysis of Alzheimer’s disease1069
The CoQ oxidoreductase FSP1 acts parallel to GPX4 to inhibit ferroptosis1036
Recycling lithium-ion batteries from electric vehicles1030
The clinical KRAS(G12C) inhibitor AMG 510 drives anti-tumour immunity998
FSP1 is a glutathione-independent ferroptosis suppressor996
Interannual extremes in the rate of rise of atmospheric carbon dioxide since 1980984
CD8+ T cells regulate tumour ferroptosis during cancer immunotherapy968
Grandmaster level in StarCraft II using multi-agent reinforcement learning911
A view on drug resistance in cancer869
Mapping the world’s free-flowing rivers865
Conserved cell types with divergent features in human versus mouse cortex849
Planar perovskite solar cells with long-term stability using ionic liquid additives841
One thousand plant transcriptomes and the phylogenomics of green plants830
Climate tipping points — too risky to bet against811
A rigorous electrochemical ammonia synthesis protocol with quantitative isotope measurements768
Transcriptome-scale super-resolved imaging in tissues by RNA seqFISH+751
Superconductors, orbital magnets and correlated states in magic-angle bilayer graphene746
Metabolic regulation of gene expression by histone lactylation736
Neoantigen vaccine generates intratumoral T cell responses in phase Ib glioblastoma trial728
The technological and economic prospects for CO2 utilization and removal708
Adjustment to climate change is constrained by arrival date in a long-distance migrant bird706
Evidence for moiré excitons in van der Waals heterostructures699
Prioritization of cancer therapeutic targets using CRISPR–Cas9 screens689
Van der Waals integration before and beyond two-dimensional materials672
Superconductivity at 250 K in lanthanum hydride under high pressures662
TOX transcriptionally and epigenetically programs CD8+ T cell exhaustion659
Graphene and two-dimensional materials for silicon technology642
Spatial and temporal heterogeneity of mouse and human microglia at single-cell resolution635
Signatures of moiré-trapped valley excitons in MoSe2/WSe2 heterobilayers631
PdMo bimetallene for oxygen reduction catalysis628
Quantifying inactive lithium in lithium metal batteries609
A new genomic blueprint of the human gut microbiota606
Genetic compensation triggered by mutant mRNA degradation597
All-optical spiking neurosynaptic networks with self-learning capabilities591
Resolving the fibrotic niche of human liver cirrhosis at single-cell level590
Supervised learning with quantum-enhanced feature spaces588
Observation of moiré excitons in WSe2/WS2 heterostructure superlattices588
Tuning element distribution, structure and properties by composition in high-entropy alloys586
Advances in epigenetics link genetics to the environment and disease581
Highly efficient and stable InP/ZnSe/ZnS quantum dot light-emitting diodes580
Importance and vulnerability of the world’s water towers576
A complete catalogue of high-quality topological materials568
Neutrophils escort circulating tumour cells to enable cell cycle progression564
The Integrative Human Microbiome Project558
A human liver cell atlas reveals heterogeneity and epithelial progenitors551
A defined commensal consortium elicits CD8 T cells and anti-cancer immunity544
NLRP3 inflammasome activation drives tau pathology542
Coral record of increased sediment flux to the inner Great Barrier Reef since European settlement535
Prediction and observation of an antiferromagnetic topological insulator521
Warming of the Antarctic ice-sheet surface since the 1957 International Geophysical Year519
Towards spike-based machine intelligence with neuromorphic computing519
Dry double-sided tape for adhesion of wet tissues and devices518
Genetic strategies for improving crop yields515
Arthropod decline in grasslands and forests is associated with landscape-level drivers502
TOX is a critical regulator of tumour-specific T cell differentiation498
CD24 signalling through macrophage Siglec-10 is a target for cancer immunotherapy497
Maximized electron interactions at the magic angle in twisted bilayer graphene496
Actively personalized vaccination trial for newly diagnosed glioblastoma495
Mapping human microbiome drug metabolism by gut bacteria and their genes493
Catalogue of topological electronic materials492
Genome-wide cell-free DNA fragmentation in patients with cancer492
Individual brain organoids reproducibly form cell diversity of the human cerebral cortex491
L1 drives IFN in senescent cells and promotes age-associated inflammation491
From discoveries in ageing research to therapeutics for healthy ageing489
Learning the signatures of the human grasp using a scalable tactile glove487
Widespread global increase in intense lake phytoplankton blooms since the 1980s486
Neoantigen-directed immune escape in lung cancer evolution480
Resonantly hybridized excitons in moiré superlattices in van der Waals heterostructures478
Anti-tumour immunity controlled through mRNA m6A methylation and YTHDF1 in dendritic cells476
A single-cell molecular map of mouse gastrulation and early organogenesis475
A clinically applicable approach to continuous prediction of future acute kidney injury475
Pan-cancer whole-genome analyses of metastatic solid tumours474
Electrical and synaptic integration of glioma into neural circuits473
Aqueous Li-ion battery enabled by halogen conversion–intercalation chemistry in graphite470
Voxelated soft matter via multimaterial multinozzle 3D printing466
Autophagy induction via STING trafficking is a primordial function of the cGAS pathway463
Global glacier mass changes and their contributions to sea-level rise from 1961 to 2016463
The bone marrow microenvironment at single-cell resolution459
Genetic analyses of diverse populations improves discovery for complex traits458
Superconductivity in an infinite-layer nickelate455
Domino electroreduction of CO2 to methanol on a molecular catalyst454
Changing climate both increases and decreases European river floods452
Bile acid metabolites control TH17 and Treg cell differentiation447
Molecular tuning of CO2-to-ethylene conversion444
Visualization and targeting of LGR5+ human colon cancer stem cells443
Unsupervised word embeddings capture latent knowledge from materials science literature438
Managing nitrogen to restore water quality in China438
Stunted microbiota and opportunistic pathogen colonization in caesarean-section birth435
TOX reinforces the phenotype and longevity of exhausted T cells in chronic viral infection427
Soil nematode abundance and functional group composition at a global scale418
Glutamatergic synaptic input to glioma cells drives brain tumour progression417
Skin-integrated wireless haptic interfaces for virtual and augmented reality417
Comprehensive search for topological materials using symmetry indicators416
The integrative biology of type 2 diabetes414
Novel tau filament fold in chronic traumatic encephalopathy encloses hydrophobic molecules413
Ultra-large library docking for discovering new chemotypes412
A national experiment reveals where a growth mindset improves achievement410
E-cadherin is required for metastasis in multiple models of breast cancer407
Distinct fibroblast subsets drive inflammation and damage in arthritis404
Proteomics identifies new therapeutic targets of early-stage hepatocellular carcinoma404
Earliest date for milk use in the Near East and southeastern Europe linked to cattle herding403
MHC-II neoantigens shape tumour immunity and response to immunotherapy403
New insights from uncultivated genomes of the global human gut microbiome402
Intercellular interaction dictates cancer cell ferroptosis via NF2–YAP signalling392
Changes in oceanic and terrestrial carbon uptake since 1982391
Additive manufacturing of ultrafine-grained high-strength titanium alloys389
Microbial bile acid metabolites modulate gut RORγ+ regulatory T cell homeostasis389
Human placenta has no microbiome but can contain potential pathogens388
Mapping the human genetic architecture of COVID-19387
Altered human oligodendrocyte heterogeneity in multiple sclerosis386
Van der Waals contacts between three-dimensional metals and two-dimensional semiconductors386
The global distribution and trajectory of tidal flats385
Charge order and broken rotational symmetry in magic-angle twisted bilayer graphene384
Whole-animal connectomes of both Caenorhabditis elegans sexes380
Drift of the major continental blocks since the Devonian378
Caspase-8 is the molecular switch for apoptosis, necroptosis and pyroptosis372
Complete biosynthesis of cannabinoids and their unnatural analogues in yeast369
Speech synthesis from neural decoding of spoken sentences368
Human blood vessel organoids as a model of diabetic vasculopathy368
Machine behaviour368
Age-related remodelling of oesophageal epithelia by mutated cancer drivers368
NR4A transcription factors limit CAR T cell function in solid tumours367
Scalable energy-efficient magnetoelectric spin–orbit logic364
Restoring natural forests is the best way to remove atmospheric carbon355
Spectroscopic signatures of many-body correlations in magic-angle twisted bilayer graphene355
Signatures of tunable superconductivity in a trilayer graphene moiré superlattice353
Organoid single-cell genomic atlas uncovers human-specific features of brain development353
The landscape of somatic mutation in normal colorectal epithelial cells353
Error mitigation extends the computational reach of a noisy quantum processor352
Genomic characterization of metastatic breast cancers352
Nitrosative stress drives heart failure with preserved ejection fraction351
Bacteriophage targeting of gut bacterium attenuates alcoholic liver disease351
Harnessing innate immunity in cancer therapy350
Modern microprocessor built from complementary carbon nanotube transistors350
Rising rural body-mass index is the main driver of the global obesity epidemic in adults347
Structural basis of STING binding with and phosphorylation by TBK1345
Broadband electro-optic frequency comb generation in a lithium niobate microring resonator343
Photoredox catalysis using infrared light via triplet fusion upconversion341
Dissociable dopamine dynamics for learning and motivation341
Magnitude of urban heat islands largely explained by climate and population340
Heterochromatin drives compartmentalization of inverted and conventional nuclei340
HIV-1 remission following CCR5Δ32/Δ32 haematopoietic stem-cell transplantation340
Gene expression across mammalian organ development340
Pol II phosphorylation regulates a switch between transcriptional and splicing condensates338
An intra-tumoral niche maintains and differentiates stem-like CD8 T cells338
Transcriptome-wide off-target RNA editing induced by CRISPR-guided DNA base editors337
c-Jun overexpression in CAR T cells induces exhaustion resistance336
Deep learning for multi-year ENSO forecasts332
Structural mechanism for NEK7-licensed activation of NLRP3 inflammasome332
Towards artificial general intelligence with hybrid Tianjic chip architecture332
A quantitative approach for measuring the reservoir of latent HIV-1 proviruses332
m6A enhances the phase separation potential of mRNA330
Colonic epithelial cell diversity in health and inflammatory bowel disease330
Brain regulatory T cells suppress astrogliosis and potentiate neurological recovery329
Atomically dispersed iron hydroxide anchored on Pt for preferential oxidation of CO in H2329
Normal faulting in central Tibet since at least 13.5 Myr ago324
Histone H3 trimethylation at lysine 36 guides m6A RNA modification co-transcriptionally324
The fungal mycobiome promotes pancreatic oncogenesis via activation of MBL321
Loss of ADAR1 in tumours overcomes resistance to immune checkpoint blockade321
Potential roles of gut microbiome and metabolites in modulating ALS in mice320
Incompatible and sterile insect techniques combined eliminate mosquitoes313
Epitaxial growth of a 100-square-centimetre single-crystal hexagonal boron nitride monolayer on copper310
A new antibiotic selectively kills Gram-negative pathogens309
Committed emissions from existing energy infrastructure jeopardize 1.5 °C climate target308
Superstructure control of first-cycle voltage hysteresis in oxygen-redox cathodes307
Genomic encoding of transcriptional burst kinetics306
Commonality despite exceptional diversity in the baseline human antibody repertoire303
Transposon-encoded CRISPR–Cas systems direct RNA-guided DNA integration303
Meningeal lymphatic vessels at the skull base drain cerebrospinal fluid300
Highly structured slow solar wind emerging from an equatorial coronal hole299
Self-verifying variational quantum simulation of lattice models297
Fatty acid transport protein 2 reprograms neutrophils in cancer297
Observation of room-temperature polar skyrmions297
GABAA receptor signalling mechanisms revealed by structural pharmacology296
Dietary methionine influences therapy in mouse cancer models and alters human metabolism295
Organization and regulation of gene transcription294
Multi-faceted particle pumps drive carbon sequestration in the ocean294
Greater vulnerability to warming of marine versus terrestrial ectotherms292
Mass balance of the Greenland Ice Sheet from 1992 to 2018292
The unexpected surface of asteroid (101955) Bennu292
Millennial-scale trends in west Pacific warm pool hydrology since the Last Glacial Maximum291
Large teams develop and small teams disrupt science and technology290
Visualizing vibrational normal modes of a single molecule with atomically confined light290
Decoding human fetal liver haematopoiesis290
Damage-tolerant architected materials inspired by crystal microstructure288
Controlled flight of a microrobot powered by soft artificial muscles286
Distributed coding of choice, action and engagement across the mouse brain285
Longitudinal multi-omics of host–microbe dynamics in prediabetes285
45.5-tesla direct-current magnetic field generated with a high-temperature superconducting magnet284
An acute immune response underlies the benefit of cardiac stem cell therapy281
Global warming impairs stock–recruitment dynamics of corals278
Data-driven design of metal–organic frameworks for wet flue gas CO2 capture278
Targeting cardiac fibrosis with engineered T cells275
Charting cellular identity during human in vitro β-cell differentiation274
Harnessing global fisheries to tackle micronutrient deficiencies273
CAR T cell trogocytosis and cooperative killing regulate tumour antigen escape272
PTC-bearing mRNA elicits a genetic compensation response via Upf3a and COMPASS components271
De novo design of potent and selective mimics of IL-2 and IL-15270
The human body at cellular resolution: the NIH Human Biomolecular Atlas Program270
Large influence of soil moisture on long-term terrestrial carbon uptake269
Hierarchical organization of cortical and thalamic connectivity269
Climatic controls of decomposition drive the global biogeography of forest-tree symbioses268
HP1 reshapes nucleosome core to promote phase separation of heterochromatin267
Self-organization and symmetry breaking in intestinal organoid development267
A wireless closed-loop system for optogenetic peripheral neuromodulation267
Tracking tumour evolution in glioma through liquid biopsies of cerebrospinal fluid267
Freestanding crystalline oxide perovskites down to the monolayer limit266
Decrease in anthropogenic lead, cadmium and zinc in Greenland snows since the late 1960s265
Cryo-EM structures of STING reveal its mechanism of activation by cyclic GMP–AMP265
Transcription factors and 3D genome conformation in cell-fate decisions264
High-dimensional geometry of population responses in visual cortex264
Specialized coding of sensory, motor and cognitive variables in VTA dopamine neurons263
Off-target RNA mutation induced by DNA base editing and its elimination by mutagenesis263
Intestinal infection triggers Parkinson’s disease-like symptoms in Pink1−/− mice263
CasX enzymes comprise a distinct family of RNA-guided genome editors263
Asia’s shrinking glaciers protect large populations from drought stress261
Site-selective and versatile aromatic C−H functionalization by thianthrenation261
MicroRNA therapy stimulates uncontrolled cardiac repair after myocardial infarction in pigs260
A distance to the Large Magellanic Cloud that is precise to one per cent260
Total synthesis of Escherichia coli with a recoded genome259
Neuronal vulnerability and multilineage diversity in multiple sclerosis258
Locally renewing resident synovial macrophages provide a protective barrier for the joint257
Observation of the nonlinear Hall effect under time-reversal-symmetric conditions256
Mitochondrial complex III is essential for suppressive function of regulatory T cells255
Cyclic GMP–AMP signalling protects bacteria against viral infection250
Visualizing DNA folding and RNA in embryos at single-cell resolution247
Plant cell-surface GIPC sphingolipids sense salt to trigger Ca2+ influx247
Controlled modelling of human epiblast and amnion development using stem cells246
The histone mark H3K36me2 recruits DNMT3A and shapes the intergenic DNA methylation landscape246
Single-cell analysis reveals T cell infiltration in old neurogenic niches245
Molybdenum-catalysed ammonia production with samarium diiodide and alcohols or water244
Environmental flow limits to global groundwater pumping244
Single-cell transcriptomes of the regenerating intestine reveal a revival stem cell240
Sex and gender analysis improves science and engineering239
Evidence of high-temperature exciton condensation in two-dimensional atomic double layers239
Alfvénic velocity spikes and rotational flows in the near-Sun solar wind239
Unveiling the double-well energy landscape in a ferroelectric layer237
Mineral protection regulates long-term global preservation of natural organic carbon237
BCAA catabolism in brown fat controls energy homeostasis through SLC25A44236
Mapping HIV prevalence in sub-Saharan Africa between 2000 and 2017234
Giant nonreciprocal second-harmonic generation from antiferromagnetic bilayer CrI3233
Evidence for an alternative fatty acid desaturation pathway increasing cancer plasticity233
Prophylactic TNF blockade uncouples efficacy and toxicity in dual CTLA-4 and PD-1 immunotherapy232
GDF15 mediates the effects of metformin on body weight and energy balance231
A second source of repeating fast radio bursts230
Developmental origin, functional maintenance and genetic rescue of osteoclasts230
Loss of p53 triggers WNT-dependent systemic inflammation to drive breast cancer metastasis229
Cleavage of RIPK1 by caspase-8 is crucial for limiting apoptosis and necroptosis227
A calmodulin-gated calcium channel links pathogen patterns to plant immunity227
Synaptic proximity enables NMDAR signalling to promote brain metastasis227
Untethered flight of an insect-sized flapping-wing microscale aerial vehicle226
Frequency of extreme Sahelian storms tripled since 1982 in satellite observations225
Multi-omics profiling of mouse gastrulation at single-cell resolution224
Topologically enabled ultrahigh-Q guided resonances robust to out-of-plane scattering223
An ultrafast symmetry switch in a Weyl semimetal223
Tumour lineage shapes BRCA-mediated phenotypes223
Climate–land-use interactions shape tropical mountain biodiversity and ecosystem functions223
Discovery of a big void in Khufu’s Pyramid by observation of cosmic-ray muons221
National food production stabilized by crop diversity221
Cryo-EM structure of the human α1β3γ2 GABAA receptor in a lipid bilayer221
Quantum Kibble–Zurek mechanism and critical dynamics on a programmable Rydberg simulator221
Circular ecDNA promotes accessible chromatin and high oncogene expression221
Genome-wide analysis identifies NR4A1 as a key mediator of T cell dysfunction220
Childhood cerebellar tumours mirror conserved fetal transcriptional programs220
Niche stiffness underlies the ageing of central nervous system progenitor cells219
Fidelity benchmarks for two-qubit gates in silicon217
Proteomics reveals NNMT as a master metabolic regulator of cancer-associated fibroblasts217
Predatory journals: no definition, no defence217
A new scenario logic for the Paris Agreement long-term temperature goal215
High frequency of shared clonotypes in human B cell receptor repertoires215
Histone serotonylation is a permissive modification that enhances TFIID binding to H3K4me3215
Metabolic heterogeneity confers differences in melanoma metastatic potential215
Longitudinal molecular trajectories of diffuse glioma in adults215
Adopt a moratorium on heritable genome editing214
Mechanosensation of cyclical force by PIEZO1 is essential for innate immunity214
The microbiota regulate neuronal function and fear extinction learning213
Increasing wildfires threaten historic carbon sink of boreal forest soils212
A late Middle Pleistocene Denisovan mandible from the Tibetan Plateau212
Constraints on the superconducting order parameter in Sr2RuO4 from oxygen-17 nuclear magnetic resonance210
CD22 blockade restores homeostatic microglial phagocytosis in ageing brains210
Resolving medulloblastoma cellular architecture by single-cell genomics210
Nanomagnetic encoding of shape-morphing micromachines209
Autophagic cell death restricts chromosomal instability during replicative crisis209
Glucocorticoids promote breast cancer metastasis209
A male-expressed rice embryogenic trigger redirected for asexual propagation through seeds207
Taking connected mobile-health diagnostics of infectious diseases to the field206
Wetland carbon storage controlled by millennial-scale variation in relative sea-level rise206
DEAD-box ATPases are global regulators of phase-separated organelles205
Tissue-resident memory CD8+ T cells promote melanoma–immune equilibrium in skin205
A fast radio burst localized to a massive galaxy204
Targeting LIF-mediated paracrine interaction for pancreatic cancer therapy and monitoring204
Exome sequencing of 20,791 cases of type 2 diabetes and 24,440 controls204
Climate and air-quality benefits of a realistic phase-out of fossil fuels203
Climate as a risk factor for armed conflict202
Cryo-EM structures and dynamics of substrate-engaged human 26S proteasome202
The emergent landscape of the mouse gut endoderm at single-cell resolution201
Allele-selective lowering of mutant HTT protein by HTT–LC3 linker compounds201
Integer factorization using stochastic magnetic tunnel junctions200
Externalized histone H4 orchestrates chronic inflammation by inducing lytic cell death200
Realization of a three-dimensional photonic topological insulator199
The expanding landscape of ‘oncohistone’ mutations in human cancers198
Two-dimensional MoS2-enabled flexible rectenna for Wi-Fi-band wireless energy harvesting198
Observation of unconventional chiral fermions with long Fermi arcs in CoSi198
Relative motions of hotspots in the Pacific, Atlantic and Indian Oceans since late Cretaceous time196
Molecular recording of mammalian embryogenesis196
Somatic mutations and clonal dynamics in healthy and cirrhotic human liver196
How to globalize the circular economy195
Evolution of the Sun's large-scale magnetic field since the Maunder minimum194
Make more digital twins194
Stem cell competition orchestrates skin homeostasis and ageing194
Spatially resolved steady-state negative capacitance194
No evidence for globally coherent warm and cold periods over the preindustrial Common Era193
Bacterial cGAS-like enzymes synthesize diverse nucleotide signals193
Sleep modulates haematopoiesis and protects against atherosclerosis193
Dynamics of oligodendrocyte generation in multiple sclerosis192
Global environmental consequences of twenty-first-century ice-sheet melt192
The population history of northeastern Siberia since the Pleistocene190
Enzymatic assembly of carbon–carbon bonds via iron-catalysed sp3 C–H functionalization190
Evidence of topological superconductivity in planar Josephson junctions189
Topological chiral crystals with helicoid-arc quantum states189
Structural insights into the activation of metabotropic glutamate receptors188
A developmental landscape of 3D-cultured human pre-gastrulation embryos187
Multiple episodes of aridity in southern Africa since the last interglacial period184
Magnetic and magnetic inverse spin Hall effects in a non-collinear antiferromagnet184
Hepatocytes direct the formation of a pro-metastatic niche in the liver184
The GenomeAsia 100K Project enables genetic discoveries across Asia184
Stretchable pumps for soft machines183
A universal biomolecular integral feedback controller for robust perfect adaptation183
Absence of NKG2D ligands defines leukaemia stem cells and mediates their immune evasion183
WRN helicase is a synthetic lethal target in microsatellite unstable cancers183
Structural variation in the gut microbiome associates with host health182
Interleukin-22 protects intestinal stem cells against genotoxic stress182
Identification of strontium in the merger of two neutron stars182
Decreasing overflow from the Nordic seas into the Atlantic Ocean through the Faroe Bank channel since 1950181
Squalene accumulation in cholesterol auxotrophic lymphomas prevents oxidative cell death181
Targeting REGNASE-1 programs long-lived effector T cells for cancer therapy181
Hindered dialkyl ether synthesis with electrogenerated carbocations180
Probing the critical nucleus size for ice formation with graphene oxide nanosheets179
Dual modes of the carbon cycle since the Last Glacial Maximum178
Super-Mendelian inheritance mediated by CRISPR–Cas9 in the female mouse germline178
Permafrost collapse is accelerating carbon release177
Isotopic evidence for the source of lead in Greenland snows since the late 1960s176
Developmental dynamics of lncRNAs across mammalian organs and species176
Sensitization of silicon by singlet exciton fission in tetracene176
Spatial and temporal distribution of mass loss from the Greenland Ice Sheet since AD 1900175
Complex networks reveal global pattern of extreme-rainfall teleconnections175
Inducing and exploiting vulnerabilities for the treatment of liver cancer175
Subducting carbon174
DDX3X acts as a live-or-die checkpoint in stressed cells by regulating NLRP3 inflammasome174
Nanosecond X-ray diffraction of shock-compressed superionic water ice173
Colossal barocaloric effects in plastic crystals172
Global spatial risk assessment of sharks under the footprint of fisheries172
Time is running out for sand171
Collapsars as a major source of r-process elements171
A two-qubit gate between phosphorus donor electrons in silicon171
Revisiting Antarctic ice loss due to marine ice-cliff instability171
Dynamics of breast-cancer relapse reveal late-recurring ER-positive genomic subgroups171
The water lily genome and the early evolution of flowering plants171
SLC19A1 transports immunoreactive cyclic dinucleotides170
Long-term ex vivo haematopoietic-stem-cell expansion allows nonconditioned transplantation170
Lattice anchoring stabilizes solution-processed semiconductors170
Three-dimensional quantum Hall effect and metal–insulator transition in ZrTe5169
Voltage imaging and optogenetics reveal behaviour-dependent changes in hippocampal dynamics169
Chimeric peptidomimetic antibiotics against Gram-negative bacteria169
Verified quantum information scrambling168
A dissipatively stabilized Mott insulator of photons168
The causes of sea-level rise since 1900167
Strategies for improving the sustainability of structural metals167
Discrete attractor dynamics underlies persistent activity in the frontal cortex167
Encoding a qubit in a trapped-ion mechanical oscillator167
Estimating and tracking the remaining carbon budget for stringent climate targets167
Structure and mechanogating of the mammalian tactile channel PIEZO2167
Compartmentalized gut lymph node drainage dictates adaptive immune responses167
Thermoelectric performance of a metastable thin-film Heusler alloy167
Cas13-induced cellular dormancy prevents the rise of CRISPR-resistant bacteriophage166
Photonic topological insulator in synthetic dimensions166
Nuclear positioning facilitates amoeboid migration along the path of least resistance166
Efficacy of MEK inhibition in patients with histiocytic neoplasms166
LHX2- and LDB1-mediated trans interactions regulate olfactory receptor choice165
Structure of the human LAT1–4F2hc heteromeric amino acid transporter complex165
Observation of the exceptional-point-enhanced Sagnac effect165
Production of phosphorene nanoribbons165
Chemical control of structure and guest uptake by a conformationally mobile porous material165
Conformational transitions of a neurotensin receptor 1–Gi1 complex165
Hydraulic control of mammalian embryo size and cell fate164
Observing crystal nucleation in four dimensions using atomic electron tomography164
Mitochondrial fission requires DRP1 but not dynamins163
Synthesis and breakdown of universal metabolic precursors promoted by iron163
Topological superconductivity in a phase-controlled Josephson junction163
Immune evasion before tumour invasion in early lung squamous carcinogenesis162
Gene expression cartography161
Structural basis of assembly of the human T cell receptor–CD3 complex160
Quantum Hall effect based on Weyl orbits in Cd3As2160
Effective breast cancer combination therapy targeting BACH1 and mitochondrial metabolism159
Force-induced conformational changes in PIEZO1157
Particle robotics based on statistical mechanics of loosely coupled components157
How 2D semiconductors could extend Moore’s law156
Activity of caspase-8 determines plasticity between cell death pathways155
Localization and delocalization of light in photonic moiré lattices155
Gboxin is an oxidative phosphorylation inhibitor that targets glioblastoma154
Population imaging of neural activity in awake behaving mice154
A small proton charge radius from an electron–proton scattering experiment154
Observations of fast radio bursts at frequencies down to 400 megahertz154
Reconstituting the transcriptome and DNA methylome landscapes of human implantation154
Modelling human hepato-biliary-pancreatic organogenesis from the foregut–midgut boundary151
Breast cancer cells rely on environmental pyruvate to shape the metastatic niche151
Mutations that prevent caspase cleavage of RIPK1 cause autoinflammatory disease151
A new twenty-first century science for effective epidemic response150
Mitochondrial protein translocation-associated degradation149
Modular click chemistry libraries for functional screens using a diazotizing reagent148
Somatic mutations and cell identity linked by Genotyping of Transcriptomes148
Epigenetic evolution and lineage histories of chronic lymphocytic leukaemia148
Predicting disruptive instabilities in controlled fusion plasmas through deep learning147
Fast and inefficient star formation due to short-lived molecular clouds and rapid feedback147
De novo design of bioactive protein switches147
Diabetes relief in mice by glucose-sensing insulin-secreting human α-cells147
Structural basis of Notch recognition by human γ-secretase147
Progenitors from the central nervous system drive neurogenesis in cancer146
Single-cell analysis of cardiogenesis reveals basis for organ-level developmental defects146
Innate lymphoid cells support regulatory T cells in the intestine through interleukin-2146
Mobile PEAR transcription factors integrate positional cues to prime cambial growth146
Roaring by red deer stags advances the date of oestrus in hinds145
SR-B1 drives endothelial cell LDL transcytosis via DOCK4 to promote atherosclerosis145
Secondary organic aerosol reduced by mixture of atmospheric vapours145
VISTA is an acidic pH-selective ligand for PSGL-1145
To catch and reverse a quantum jump mid-flight144
High levels of auxin signalling define the stem-cell organizer of the vascular cambium144
Site-specific allylic C–H bond functionalization with a copper-bound N-centred radical143
Conformation space of a heterodimeric ABC exporter under turnover conditions143
Apidima Cave fossils provide earliest evidence of Homo sapiens in Eurasia143
Multiplex chromatin interactions with single-molecule precision143
Distinct structural classes of activating FOXA1 alterations in advanced prostate cancer143
Cortical pattern generation during dexterous movement is input-driven143
The prevalence of Plasmodium falciparum in sub-Saharan Africa since 1900142
Convergent estimates of marine nitrogen fixation142
A conserved PLPLRT/SD motif of STING mediates the recruitment and activation of TBK1142
Large magnetic gap at the Dirac point in Bi2Te3/MnBi2Te4 heterostructures142
Architecture of autoinhibited and active BRAF–MEK1–14-3-3 complexes141
Rubisco condensate formation by CcmM in β-carboxysome biogenesis140
Attosecond angular streaking and tunnelling time in atomic hydrogen140
Efficient molecular doping of polymeric semiconductors driven by anion exchange139
Anatomy and resilience of the global production ecosystem139
Thermal stress induces glycolytic beige fat formation via a myogenic state139
Diverse and robust molecular algorithms using reprogrammable DNA self-assembly138
Teraelectronvolt emission from the γ-ray burst GRB 190114C137
Twentieth-century hydroclimate changes consistent with human influence137
Somatic inflammatory gene mutations in human ulcerative colitis epithelium136
High-temperature superconductivity in monolayer Bi2Sr2CaCu2O8+δ136
H+ transport is an integral function of the mitochondrial ADP/ATP carrier136
Light-wave dynamic control of magnetism135
Structural basis of coreceptor recognition by HIV-1 envelope spike135
Identifying the pathways required for coping behaviours associated with sustained pain135
Microbiota-derived lantibiotic restores resistance against vancomycin-resistant Enterococcus134
Why deep-learning AIs are so easy to fool133
Intrinsically stable organic solar cells under high-intensity illumination133
Serotonin transporter–ibogaine complexes illuminate mechanisms of inhibition and transport132
Metal-free directed sp2-C–H borylation132
The corona contracts in a black-hole transient132
α-Ketoglutarate links p53 to cell fate during tumour suppression132
Atypical behaviour and connectivity in SHANK3-mutant macaques132
Holistic prediction of enantioselectivity in asymmetric catalysis131
Mitochondrial fragmentation drives selective removal of deleterious mtDNA in the germline131
Identification of an ATP-sensitive potassium channel in mitochondria131
Molecular streaming and its voltage control in ångström-scale channels130
Deep fracture fluids isolated in the crust since the Precambrian era129
Arabidopsis FLL2 promotes liquid–liquid phase separation of polyadenylation complexes129
Heterogeneity in old fibroblasts is linked to variability in reprogramming and wound healing129
Regulation of α-synuclein by chaperones in mammalian cells129
California’s methane super-emitters128
Air pollution: a global problem needs local fixes127
Observation of thermal Hawking radiation and its temperature in an analogue black hole127
High-temperature bulk metallic glasses developed by combinatorial methods127
Smoothened stimulation by membrane sterols drives Hedgehog pathway activity127
Restoration of brain circulation and cellular functions hours post-mortem127
Real-time discrimination of earthquake foreshocks and aftershocks126
Object-vector coding in the medial entorhinal cortex126
A new species of Homo from the Late Pleistocene of the Philippines126
Associating HIV-1 envelope glycoprotein structures with states on the virus observed by smFRET126
Genetic predisposition to mosaic Y chromosome loss in blood126
Single-neuron perturbations reveal feature-specific competition in V1125
Enhanced intrinsic photovoltaic effect in tungsten disulfide nanotubes124
Interacting neural ensembles in orbitofrontal cortex for social and feeding behaviour124
Windborne long-distance migration of malaria mosquitoes in the Sahel124
FACT caught in the act of manipulating the nucleosome124
A volumetric display for visual, tactile and audio presentation using acoustic trapping123
Mechanisms of RALF peptide perception by a heterotypic receptor complex123
Reverse-engineering the locomotion of a stem amniote123
Immunization expands B cells specific to HIV-1 V3 glycan in mice and macaques123
Hyperbolic lattices in circuit quantum electrodynamics122
How to win public support for a global carbon tax122
FTSJ3 is an RNA 2′-O-methyltransferase recruited by HIV to avoid innate immune sensing122
Visualizing Poiseuille flow of hydrodynamic electrons122
Observed controls on resilience of groundwater to climate variability in sub-Saharan Africa122
Exome sequencing of Finnish isolates enhances rare-variant association power122
PhDs: the tortuous truth121
Non-Hermitian ring laser gyroscopes with enhanced Sagnac sensitivity121
Introns are mediators of cell response to starvation121
Viral and metazoan poxins are cGAMP-specific nucleases that restrict cGAS–STING signalling121
Molecular architecture of lineage allocation and tissue organization in early mouse embryo121
Distinct modes of mitochondrial metabolism uncouple T cell differentiation and function121
Mammalian ISWI and SWI/SNF selectively mediate binding of distinct transcription factors120
Salmonella persisters promote the spread of antibiotic resistance plasmids in the gut120
GPR31-dependent dendrite protrusion of intestinal CX3CR1+ cells by bacterial metabolites120
Millennial-scale changes in North Atlantic circulation since the last glaciation119
Cavity quantum electrodynamics with atom-like mirrors119
A dominant autoinflammatory disease caused by non-cleavable variants of RIPK1119
Ionic-surfactant-mediated electro-dewetting for digital microfluidics118
Oxytocin-dependent reopening of a social reward learning critical period with MDMA118
NAD metabolic dependency in cancer is shaped by gene amplification and enhancer remodelling118
Analysis of the B cell receptor repertoire in six immune-mediated diseases118
Insights into ubiquitin chain architecture using Ub-clipping117
Altered chromosomal topology drives oncogenic programs in SDH-deficient GISTs117
Mid-latitude net precipitation decreased with Arctic warming during the Holocene116
Chromatin structure dynamics during the mitosis-to-G1 phase transition116
Spliceosomal disruption of the non-canonical BAF complex in cancer116
Increase in CFC-11 emissions from eastern China based on atmospheric observations116
The Drug Rediscovery protocol facilitates the expanded use of existing anticancer drugs116
Group 3 innate lymphoid cells mediate early protective immunity against tuberculosis116
Hominin occupation of the Chinese Loess Plateau since about 2.1 million years ago115
Comprehensive single-cell transcriptome lineages of a proto-vertebrate115
Anaerobic oxidation of ethane by archaea from a marine hydrocarbon seep115
Coordinated alterations in RNA splicing and epigenetic regulation drive leukaemogenesis115
IL-17a promotes sociability in mouse models of neurodevelopmental disorders115
Metabolic heterogeneity underlies reciprocal fates of TH17 cell stemness and plasticity115
FOXA1 mutations alter pioneering activity, differentiation and prostate cancer phenotypes114
Targeting the CBM complex causes Treg cells to prime tumours for immune checkpoint therapy114
Notum produced by Paneth cells attenuates regeneration of aged intestinal epithelium114
Meridional flows in the disk around a young star113
Make scientific data FAIR113
High performance from extraordinarily thick organic light-emitting diodes113
Stabilization of chromatin topology safeguards genome integrity113
TMK1-mediated auxin signalling regulates differential growth of the apical hook113
Genomic insights into the 2016–2017 cholera epidemic in Yemen113
Colouration by total internal reflection and interference at microscale concave interfaces112
Large electrocaloric effects in oxide multilayer capacitors over a wide temperature range112
scSLAM-seq reveals core features of transcription dynamics in single cells112
Wilderness areas halve the extinction risk of terrestrial biodiversity111
Climate change and overfishing increase neurotoxicant in marine predators111
Alcohol metabolism contributes to brain histone acetylation111
Regulation of lifespan by neural excitation and REST111
Chang’E-4 initial spectroscopic identification of lunar far-side mantle-derived materials111
The ADP/ATP translocase drives mitophagy independent of nucleotide exchange111
A wide star–black-hole binary system from radial-velocity measurements111
Frequent mutations that converge on the NFKBIZ pathway in ulcerative colitis111
Mapping 123 million neonatal, infant and child deaths between 2000 and 2017111
Electrochemically reconfigurable architected materials110
Time-resolved protein activation by proximal decaging in living systems110
Energy of the 229Th nuclear clock transition110
Developmental ROS individualizes organismal stress resistance and lifespan110
The CH25H–CYP7B1–RORα axis of cholesterol metabolism regulates osteoarthritis110
Structural basis of ligand recognition at the human MT1 melatonin receptor110
Astrophysical detection of the helium hydride ion HeH+109
Atomic-scale imaging of a 27-nuclear-spin cluster using a quantum sensor109
RETRACTED ARTICLE: Complex societies precede moralizing gods throughout world history109
A radical switch in clonality reveals a stem cell niche in the epiphyseal growth plate109
Birth date and sporting success108
A gated quantum dot strongly coupled to an optical microcavity108
Light-entrained and brain-tuned circadian circuits regulate ILC3s and gut homeostasis108
HIF-1α metabolically controls collagen synthesis and modification in chondrocytes108
Metabolic reprogramming by the S-nitroso-CoA reductase system protects against kidney injury108
A very-high-energy component deep in the γ-ray burst afterglow108
Cryo-EM structure of oxysterol-bound human Smoothened coupled to a heterotrimeric Gi107
Early fungi from the Proterozoic era in Arctic Canada107
Machine learning in electronic-quantum-matter imaging experiments107
Structures of influenza A virus RNA polymerase offer insight into viral genome replication107
Opposing T cell responses in experimental autoimmune encephalomyelitis107
Internal state dynamics shape brainwide activity and foraging behaviour107
Programmable design of orthogonal protein heterodimers107
In vivo imaging of mitochondrial membrane potential in non-small-cell lung cancer106
TRAIP is a master regulator of DNA interstrand crosslink repair105
Structure of the mitochondrial import gate reveals distinct preprotein paths105
Dynamics and genomic landscape of CD8+ T cells undergoing hepatic priming105
Skin sensors are the future of health care104
Immunization: vital progress, unfinished agenda104
Crosslinking ionic oligomers as conformable precursors to calcium carbonate104
Selective triplet exciton formation in a single molecule104
Prepare river ecosystems for an uncertain future104
Subthreshold firing in Mott nanodevices104
A dominant population of optically invisible massive galaxies in the early Universe104
Structural basis of lipopolysaccharide extraction by the LptB2FGC complex103
Sensorimotor experience remaps visual input to a heading-direction network103
Temporal and spectral fingerprints of ultrafast all-coherent spin switching103
Structure and autoregulation of a P4-ATPase lipid flippase103
Syndecan 1 is a critical mediator of macropinocytosis in pancreatic cancer103
A bacteriophage nucleus-like compartment shields DNA from CRISPR nucleases103
Designing minimal and scalable insect-inspired multi-locomotion millirobots102
Metamorphism and the evolution of plate tectonics102
Ultrafast spin-lasers102
The low-energy Goldstone mode in a trapped dipolar supersolid102
Supersolid symmetry breaking from compressional oscillations in a dipolar quantum gas102
Discovery of a pathway for terminal-alkyne amino acid biosynthesis102
Innervation of thermogenic adipose tissue via a calsyntenin 3β–S100b axis102
Trace metals in Antarctic snows since 1914101
Anthropogenic biases in chemical reaction data hinder exploratory inorganic synthesis101
Timing of archaic hominin occupation of Denisova Cave in southern Siberia101
Resonant microwave-mediated interactions between distant electron spins101
Observation of inverse Compton emission from a long γ-ray burst101
Axionic charge-density wave in the Weyl semimetal (TaSe4)2I100
Nonreciprocal control and cooling of phonon modes in an optomechanical system99
Natural selection on the Arabidopsis thaliana genome in present and future climates99
The U1 spliceosomal RNA is recurrently mutated in multiple cancers99
Visualizing electrostatic gating effects in two-dimensional heterostructures99
Recurrent noncoding U1 snRNA mutations drive cryptic splicing in SHH medulloblastoma99
Frontal cortex neuron types categorically encode single decision variables98
Structure of the complex I-like molecule NDH of oxygenic photosynthesis98
Structural basis of nucleosome recognition and modification by MLL methyltransferases98
Thermodynamic signatures of quantum criticality in cuprate superconductors98
Deacylative transformations of ketones via aromatization-promoted C–C bond activation97
Structural colour using organized microfibrillation in glassy polymer films97
Dietary salt promotes cognitive impairment through tau phosphorylation97
UDP-glucose accelerates SNAI1 mRNA decay and impairs lung cancer metastasis97
Absence of a thick atmosphere on the terrestrial exoplanet LHS 3844b97
Mapping changes in housing in sub-Saharan Africa from 2000 to 201597
The ultrafast Einstein–de Haas effect97
Gut intraepithelial T cells calibrate metabolism and accelerate cardiovascular disease97
Mandate vaccination with care96
Climate change and tropical cyclone trend96
Excised linear introns regulate growth in yeast96
Electrolytic vascular systems for energy-dense robots96
Optical clock comparison for Lorentz symmetry testing96
Age estimates for hominin fossils and the onset of the Upper Palaeolithic at Denisova Cave96
Activation of PDGF pathway links LMNA mutation to dilated cardiomyopathy96
Early Pleistocene enamel proteome from Dmanisi resolves Stephanorhinus phylogeny96
Challenges in evidencing the earliest traces of life95
Stellar mergers as the origin of magnetic massive stars95
Earliest hunting scene in prehistoric art95
Key role for CTCF in establishing chromatin structure in human embryos95
Collapsing glaciers threaten Asia’s water supplies94
Tissue curvature and apicobasal mechanical tension imbalance instruct cancer morphogenesis94
Asymmetric lysosome inheritance predicts activation of haematopoietic stem cells94
High-resolution lineage tracking reveals travelling wave of adaptation in laboratory yeast94
PU.1 controls fibroblast polarization and tissue fibrosis94
Large-scale chemical–genetics yields new M. tuberculosis inhibitor classes94
Subcellular transcriptomes and proteomes of developing axon projections in the cerebral cortex93
An ultra-stable gold-coordinated protein cage displaying reversible assembly93
Structure of the post-translational protein translocation machinery of the ER membrane93
Genetic induction and mechanochemical propagation of a morphogenetic wave92
Accretion of a giant planet onto a white dwarf star92
Non-line-of-sight imaging using phasor-field virtual wave optics92
Emergence of tissue-like mechanics from fibrous networks confined by close-packed cells92
Phytoplankton productivity in the North Pacific ocean since 1900 and implications for absorption of anthropogenic CO291
Quantum critical behaviour at the many-body localization transition91
Cryo-EM structures of apo and antagonist-bound human Cav3.191
Thermal conductance of single-molecule junctions91
A unified mechanism for intron and exon definition and back-splicing91
The fundamental role of chromatin loop extrusion in physiological V(D)J recombination91
An apical hypoxic niche sets the pace of shoot meristem activity91
Real-space charge-density imaging with sub-ångström resolution by four-dimensional electron microscopy91
A large source of cloud condensation nuclei from new particle formation in the tropics91
An antiaromatic-walled nanospace90
Generation of stable heading representations in diverse visual scenes90
Distinct modes of cell competition shape mammalian tissue morphogenesis90
Structure and drug resistance of the Plasmodium falciparum transporter PfCRT90
No detection of methane on Mars from early ExoMars Trace Gas Orbiter observations90
Patch repair of deep wounds by mobilized fascia89
Structure of the inner kinetochore CCAN complex assembled onto a centromeric nucleosome89
Onset of differentiation is post-transcriptionally controlled in adult neural stem cells89
Tracing the origin of adult intestinal stem cells89
β-Synuclein-reactive T cells induce autoimmune CNS grey matter degeneration89
Surface erosion events controlled the evolution of plate tectonics on Earth89
Structural basis of unidirectional export of lipopolysaccharide to the cell surface89
Formation of massive black holes in rapidly growing pre-galactic gas clouds89
What’s next for Registered Reports?88
Five decades of northern land carbon uptake revealed by the interhemispheric CO2 gradient88
Lipid signalling drives proteolytic rewiring of mitochondria by YME1L88
Spin–orbit-driven band inversion in bilayer graphene by the van der Waals proximity effect88
Metastatic-niche labelling reveals parenchymal cells with stem features88
RETRACTED ARTICLE: A 10 per cent increase in global land evapotranspiration from 2003 to 201988
A sensory appendage protein protects malaria vectors from pyrethroids88
SETD3 is an actin histidine methyltransferase that prevents primary dystocia88
Martian dust storm impact on atmospheric H2O and D/H observed by ExoMars Trace Gas Orbiter88
Continued decline of total ozone over Halley, Antarctica, since 198587
The reality behind solar power’s next star material87
Peptide ligation by chemoselective aminonitrile coupling in water87
Waveguide-coupled single collective excitation of atomic arrays87
Transcriptional cofactors display specificity for distinct types of core promoters87
Phylogenetic evidence for Sino-Tibetan origin in northern China in the Late Neolithic86
Genome editing retraces the evolution of toxin resistance in the monarch butterfly86
RGF1 controls root meristem size through ROS signalling86
A weak topological insulator state in quasi-one-dimensional bismuth iodide86
78Ni revealed as a doubly magic stronghold against nuclear deformation86
Chiral twisted van der Waals nanowires85
Plasma membrane V-ATPase controls oncogenic RAS-induced macropinocytosis85
Modulation of cardiac ryanodine receptor 2 by calmodulin85
Resolving the energy levels of a nanomechanical oscillator85
An interbacterial toxin inhibits target cell growth by synthesizing (p)ppApp85
Lactonization as a general route to β-C(sp3)–H functionalization85
XFEL structures of the human MT2 melatonin receptor reveal the basis of subtype selectivity85
Probing the energetic particle environment near the Sun85
Broadening not strengthening of the Agulhas Current since the early 1990s84
Weak average liquid-cloud-water response to anthropogenic aerosols84
Calicivirus VP2 forms a portal-like assembly following receptor engagement84
Parallel entangling operations on a universal ion-trap quantum computer84
Predator-induced collapse of niche structure and species coexistence84
Insights into the assembly and activation of the microtubule nucleator γ-TuRC84
Fundamental roles of chromatin loop extrusion in antibody class switching83
Hidden resilience and adaptive dynamics of the global online hate ecology83
De novo protein design by citizen scientists83
Palaeo-Eskimo genetic ancestry and the peopling of Chukotka and North America83
Rein in the four horsemen of irreproducibility82
Three pitfalls to avoid in machine learning82
An N-nitrosating metalloenzyme constructs the pharmacophore of streptozotocin82
Neural signatures of sleep in zebrafish82
Imaging magnetic polarons in the doped Fermi–Hubbard model82
H2A.Z facilitates licensing and activation of early replication origins82
Computational periscopy with an ordinary digital camera81
Chemotaxis as a navigation strategy to boost range expansion81
Neogene cooling driven by land surface reactivity rather than increased weathering fluxes81
Mechanism of DNA translocation underlying chromatin remodelling by Snf281
Transposon molecular domestication and the evolution of the RAG recombinase81
KRAS4A directly regulates hexokinase 181
Non-photosynthetic predators are sister to red algae80
Mediterranean winter rainfall in phase with African monsoons during the past 1.36 million years80
An allosteric mechanism for potent inhibition of human ATP-citrate lyase79
Inhibition of bacterial ubiquitin ligases by SidJ–calmodulin catalysed glutamylation79
Structural insights into the mechanism of human soluble guanylate cyclase78
Interlayer exciton laser of extended spatial coherence in atomically thin heterostructures78
Cryo-EM structures of herpes simplex virus type 1 portal vertex and packaged genome78
p53 regulation of ammonia metabolism through urea cycle controls polyamine biosynthesis78
Regulation of phosphoribosyl ubiquitination by a calmodulin-dependent glutamylase78
A general theoretical and experimental framework for nanoscale electromagnetism77
Structure of ATP citrate lyase and the origin of citrate synthase in the Krebs cycle77
PKG1-modified TSC2 regulates mTORC1 activity to counter adverse cardiac stress77
Tripled yield in direct-drive laser fusion through statistical modelling77
Modified structure of protons and neutrons in correlated pairs76
Mechanism of head-to-head MCM double-hexamer formation revealed by cryo-EM76
Pluripotency and the origin of animal multicellularity76
Genome–lamina interactions are established de novo in the early mouse embryo76
A gut-to-brain signal of fluid osmolarity controls thirst satiation76
Core crystallization and pile-up in the cooling sequence of evolving white dwarfs76
Modular and tunable biological feedback control using a de novo protein switch76
Forearc carbon sink reduces long-term volatile recycling into the mantle76
Observation of two-neutrino double electron capture in 124Xe with XENON1T75
Resonant electro-optic frequency comb75
Exposing Anopheles mosquitoes to antimalarials blocks Plasmodium parasite transmission75
Late steps in bacterial translation initiation visualized using time-resolved cryo-EM75
LLGL2 rescues nutrient stress by promoting leucine uptake in ER+ breast cancer75
Human gut bacteria contain acquired interbacterial defence systems75
Immunity to commensal papillomaviruses protects against skin cancer75
Amino-acid Sequences of Kangaroo Myoglobin and Haemoglobin and the Date of Marsupial-Eutherian Divergence74
Priorities for the next 10 years of human microbiome research74
Global change drives modern plankton communities away from the pre-industrial state74
Twofold expansion of the Indo-Pacific warm pool warps the MJO life cycle74
Giant thermal Hall conductivity in the pseudogap phase of cuprate superconductors74
Nine-hour X-ray quasi-periodic eruptions from a low-mass black hole galactic nucleus74
An integrative systems genetic analysis of mammalian lipid metabolism74
Globally resolved surface temperatures since the Last Glacial Maximum73
How much can forests fight climate change?73
Memory editing from science fiction to clinical practice73
Information gerrymandering and undemocratic decisions73
Position and momentum mapping of vibrations in graphene nanostructures73
Bacterial biodiversity drives the evolution of CRISPR-based phage resistance73
Flower isoforms promote competitive growth in cancer73
Inflation of 430-parsec bipolar radio bubbles in the Galactic Centre by an energetic event73
Increasing subtropical North Pacific Ocean nitrogen fixation since the Little Ice Age72
Tracing the US opioid crisis to its roots72
A potassium channel β-subunit couples mitochondrial electron transport to sleep72
Random anti-lasing through coherent perfect absorption in a disordered medium72
Attachment of the blastoderm to the vitelline envelope affects gastrulation of insects72
Structure and mechanism of the cation–chloride cotransporter NKCC172
A mutation-independent approach for muscular dystrophy via upregulation of a modifier gene72
Enzyme-catalysed [6+4] cycloadditions in the biosynthesis of natural products72
BORIS promotes chromatin regulatory interactions in treatment-resistant cancer cells72
Isomerization of BRCA1–BARD1 promotes replication fork protection72
MHC class II proteins mediate cross-species entry of bat influenza viruses72
Last appearance of Homo erectus at Ngandong, Java, 117,000–108,000 years ago72
HBO1 is required for the maintenance of leukaemia stem cells72
China’s tree-planting drive could falter in a warming world71
Temporal plasticity of apical progenitors in the developing mouse neocortex71
Stationary entangled radiation from micromechanical motion71
A widespread coral-infecting apicomplexan with chlorophyll biosynthesis genes71
Global satellite-observed daily vertical migrations of ocean animals71
Precise therapeutic gene correction by a simple nuclease-induced double-stranded break71
General relativistic orbital decay in a seven-minute-orbital-period eclipsing binary system71
Disinformation’s spread: bots, trolls and all of us70
Quaternary-centre-guided synthesis of complex polycyclic terpenes70
Entanglement of bosonic modes through an engineered exchange interaction70
Lysine harvesting is an antioxidant strategy and triggers underground polyamine metabolism70
FOXK1 and FOXK2 regulate aerobic glycolysis70
Signatures of a jet cocoon in early spectra of a supernova associated with a γ-ray burst70
Classify viruses — the gain is worth the pain69
Light-driven anaerobic microbial oxidation of manganese69
Architecture of the mycobacterial type VII secretion system69
Small-molecule ion channels increase host defences in cystic fibrosis airway epithelia69
Structure of the Fanconi anaemia monoubiquitin ligase complex69
Put equity first in climate adaptation68
Southward propagation of Nazca subduction along the Andes68
Structures of an RNA polymerase promoter melting intermediate elucidate DNA unwinding68
Active chromatin marks drive spatial sequestration of heterochromatin in C. elegans nuclei68
Singlet molecular oxygen regulates vascular tone and blood pressure in inflammation68
Similar scaling laws for earthquakes and Cascadia slow-slip events67
Controlling protein assembly on inorganic crystals through designed protein interfaces67
Design and evolution of an enzyme with a non-canonical organocatalytic mechanism67
Cholera toxin promotes pathogen acquisition of host-derived nutrients66
Four steps to food security for swelling cities66
Why and where an HIV cure is needed and how it might be achieved66
Electrical resistivity across a nematic quantum critical point66
Humans are driving one million species to extinction65
Straightforward access to N-trifluoromethyl amides, carbamates, thiocarbamates and ureas65
Neural circuits underlying a psychotherapeutic regimen for fear disorders65
Cryo-EM structure of the spinach cytochrome b6 f complex at 3.6 Å resolution65
Human origins in a southern African palaeo-wetland and first migrations65
Ultrahigh-pressure isostructural electronic transitions in hydrogen65
A magnetar-powered X-ray transient as the aftermath of a binary neutron-star merger65
Helical van der Waals crystals with discretized Eshelby twist65
Confinement of atomically defined metal halide sheets in a metal–organic framework65
The molecular landscape of ETMR at diagnosis and relapse65
Tainted water: the scientists tracing thousands of fluorinated chemicals in our environment64
Migrant memory B cells secrete luminal antibody in the vagina64
A glucose-sensing neuron pair regulates insulin and glucagon in Drosophila64
Disruption of the Orion molecular core 1 by wind from the massive star θ1 Orionis C64
Structure and assembly of the mitochondrial membrane remodelling GTPase Mgm164
Near-Sun observations of an F-corona decrease and K-corona fine structure64
Direct laboratory determination of the 187Re half-life63
Why the US–China trade war spells disaster for the Amazon63
Rapid expansion of Greenland’s low-permeability ice slabs63
PGRMC2 is an intracellular haem chaperone critical for adipocyte function63
Growth dynamics in naturally progressing chronic lymphocytic leukaemia63
Electric field correlation measurements on the electromagnetic vacuum state62
Near-field photonic cooling through control of the chemical potential of photons62
An X-ray chimney extending hundreds of parsecs above and below the Galactic Centre62
Visualization of clustered protocadherin neuronal self-recognition complexes62
MLLT3 governs human haematopoietic stem-cell self-renewal and engraftment62
Habenular TCF7L2 links nicotine addiction to diabetes62
The CRISPR-baby scandal: what’s next for human gene-editing61
Insect egg size and shape evolve with ecology but not developmental rate61
RETRACTED ARTICLE: Living annulative π-extension polymerization for graphene nanoribbon synthesis61
Two-million-year-old snapshots of atmospheric gases from Antarctic ice61
Trapping biosynthetic acyl-enzyme intermediates with encoded 2,3-diaminopropionic acid61
Social dilemmas among unequals60
Death march of a segmented and trilobate bilaterian elucidates early animal evolution60
Large hydropower and water-storage potential in future glacier-free basins60
UNC93B1 recruits syntenin-1 to dampen TLR7 signalling and prevent autoimmunity60
Controlling organization and forces in active matter through optically defined boundaries60
Enamel proteome shows that Gigantopithecus was an early diverging pongine60
Cooling and freshening of the subpolar North Atlantic Ocean since the 1960s59
Millions of black people affected by racial bias in health-care algorithms59
Observation of fermion-mediated interactions between bosonic atoms59
Measurement of quantum back action in the audio band at room temperature59
Structural basis of ligand recognition and self-activation of orphan GPR5259
India's and Australia's pole path since the late Mesozoic and the India–Asia collision58
Recalibration of path integration in hippocampal place cells58
Structure of the IFNγ receptor complex guides design of biased agonists58
A sensor kinase controls turgor-driven plant infection by the rice blast fungus58
Structural basis of DNA targeting by a transposon-encoded CRISPR–Cas system58
Structure of Plasmodium falciparum Rh5–CyRPA–Ripr invasion complex58
Positive selection at sites of multiple amino acid replacements since rat–mouse divergence57
Hundreds of extreme self-citing scientists revealed in new database57
Analogue quantum chemistry simulation57
Global entangling gates on arbitrary ion qubits57
Structural basis for enzymatic photocatalysis in chlorophyll biosynthesis57
Structure of the human metapneumovirus polymerase phosphoprotein complex57
Author Correction: Virological assessment of hospitalized patients with COVID-201957
Beware of plausible predictions of fantasy materials56
Antarctic offshore polynyas linked to Southern Hemisphere climate anomalies56
A new Miocene ape and locomotion in the ancestor of great apes and humans56
Capture of nebular gases during Earth’s accretion is preserved in deep-mantle neon56
Neuromodulatory control of localized dendritic spiking in critical period cortex55
Aridity is expressed in river topography globally55
Tracking the precession of single nuclear spins by weak measurements55
A hexagonal planar transition-metal complex55
DNA damage detection in nucleosomes involves DNA register shifting55
p38γ is essential for cell cycle progression and liver tumorigenesis55
Late Middle Pleistocene Levallois stone-tool technology in southwest China55
An AI boost for clinical trials54
How China will protect one-quarter of its land54
Phonon heat transfer across a vacuum through quantum fluctuations54
Coherent spin-state transfer via Heisenberg exchange54
Constraints on global mean sea level during Pliocene warmth54
Recruitment of BRCA1 limits MYCN-driven accumulation of stalled RNA polymerase54
A rapidly changing jet orientation in the stellar-mass black-hole system V404 Cygni54
U–Pb-dated flowstones restrict South African early hominin record to dry climate phases54
Impaired cell fate through gain-of-function mutations in a chromatin reader54
The formation of Jupiter’s diluted core by a giant impact53
Sound velocity of CaSiO3 perovskite suggests the presence of basaltic crust in the Earth’s lower mantle53
Carrier-resolved photo-Hall effect53
Maternal vitamin C regulates reprogramming of DNA methylation and germline development53
RETRACTED ARTICLE: Global analysis of streamflow response to forest management52
Rotation tracking of genome-processing enzymes using DNA origami rotors52
Polymers with controlled assembly and rigidity made with click-functional peptide bundles52
CDK phosphorylation of TRF2 controls t-loop dynamics during the cell cycle52
Marine Proteobacteria metabolize glycolate via the β-hydroxyaspartate cycle52
A new date for the Taupo eruption, New Zealand51
15-Myr periodicity in the frequency of geomagnetic reversals since 100 Myr51
Mapping orbital changes upon electron transfer with tunnelling microscopy on insulators51
Sampling the volatile-rich transition zone beneath Bermuda51
Evolution of the new head by gradual acquisition of neural crest regulatory circuits51
Seeing mesoatomic distortions in soft-matter crystals of a double-gyroid block copolymer51
The centrosome protein AKNA regulates neurogenesis via microtubule organization51
Why young climate activists have captured the world’s attention50
Women who win prizes get less money and prestige50
Quantum-enhanced sensing of a single-ion mechanical oscillator50
Greenland melt drives continuous export of methane from the ice-sheet bed50
Direct observation of incommensurate magnetism in Hubbard chains50
Needle-like structures discovered on positively charged lightning branches50
Selecting Rhizobium for acid, infertile soils of the tropics49
Uncertainties in tropical-cyclone translation speed49
Isotopic constraint on the twentieth-century increase in tropospheric ozone49
Dynamic lineage priming is driven via direct enhancer regulation by ERK49
Sensory experience remodels genome architecture in neural circuit to drive motor learning49
Crystal structure of heliorhodopsin49
The Development of Taxonomic Theory Since 185148
Fix the broken food system in three steps48
Upper-plate rigidity determines depth-varying rupture behaviour of megathrust earthquakes48
Hypersonic Bose–Einstein condensates in accelerator rings48
S-Geranylgeranyl-l-glutathione is a ligand for human B cell-confinement receptor P2RY848
Hypo-osmotic-like stress underlies general cellular defects of aneuploidy48
Genome architecture and stability in the Saccharomyces cerevisiae knockout collection48
The amplitude and origin of sea-level variability during the Pliocene epoch47
X-ray pumping of the 229Th nuclear clock isomer47
A GPR174–CCL21 module imparts sexual dimorphism to humoral immunity47
Widespread phytoplankton blooms triggered by 2019–2020 Australian wildfires47
Temporal evolution of nitrogen compounds in Swedish precipitation since 195547
The digitization of organic synthesis47
Eat less meat: UN climate-change report calls for change to human diet47
Kimberlites reveal 2.5-billion-year evolution of a deep, isolated mantle reservoir47
Low-barrier hydrogen bonds in enzyme cooperativity47
Structural basis for KCTD-mediated rapid desensitization of GABAB signalling46
Collisions between cold molecules in a superconducting magnetic trap46
Industrial-era decline in subarctic Atlantic productivity46
Deep hydrous mantle reservoir provides evidence for crustal recycling before 3.3 billion years ago46
Long-term cyclic persistence in an experimental predator–prey system46
A vitamin-C-derived DNA modification catalysed by an algal TET homologue46
Chemistry Nobel honours world-changing batteries45
One neuron versus deep learning in aftershock prediction45
Disaster-zone research needs a code of conduct45
Structure and mechanism of mitochondrial proton-translocating transhydrogenase45
eIF5B gates the transition from translation initiation to elongation45
Structure and function of Vms1 and Arb1 in RQC and mitochondrial proteome homeostasis45
A kiwellin disarms the metabolic activity of a secreted fungal virulence factor45
Multiple liquid crystalline geometries of highly compacted nucleic acid in a dsRNA virus45
Rethink government with AI44
Data sharing and how it can benefit your scientific career44
Self-destructing mosquitoes and sterilized rodents: the promise of gene drives44
Turbulent convective length scale in planetary cores44
A 16-step synthesis of the isoryanodane diterpene (+)-perseanol44
A statistical solution to the chaotic, non-hierarchical three-body problem44
Real-time vibrations of a carbon nanotube44
Self-coalescing flows in microfluidics for pulse-shaped delivery of reagents44
Engineering orthogonal signalling pathways reveals the sparse occupancy of sequence space44
Female-biased embryonic death from inflammation induced by genomic instability44
Feature-selective encoding of substrate vibrations in the forelimb somatosensory cortex43
A new Jurassic scansoriopterygid and the loss of membranous wings in theropod dinosaurs43
Deep electrical imaging of the ultraslow-spreading Mohns Ridge43
Drink more recycled wastewater43
Measurability of pressure inside the proton42
How AI and neuroscience drive each other forwards42
Better methods can’t make up for mediocre theory42
The structures and gating mechanism of human calcium homeostasis modulator 242
Save reefs to rescue all ecosystems42
Release from UNC93B1 reinforces the compartmentalized activation of select TLRs42
Anthropocene now: influential panel votes to recognize Earth’s new epoch42
RB constrains lineage fidelity and multiple stages of tumour progression and metastasis42
Depression researchers rethink popular mouse swim tests41
Don’t let industry write the rules for AI41
The new frontier of gravitational waves41
Four steps to extend drone use in research41
A 3.8-million-year-old hominin cranium from Woranso-Mille, Ethiopia41
Australian gene-editing rules adopt ‘middle ground’41
An actin-based viscoplastic lock ensures progressive body-axis elongation41
Treatment of type 2 diabetes with the designer cytokine IC7Fc41
Study what makes games addictive40
Julia: come for the syntax, stay for the speed40
Model and manage the changing geopolitics of energy40
Elemental signatures of Australopithecus africanus teeth reveal seasonal dietary stress40
A 100-kiloparsec wind feeding the circumgalactic medium of a massive compact galaxy40
Metabolic control of BRISC–SHMT2 assembly regulates immune signalling40
FHL1 is a major host factor for chikungunya virus infection40
Glaciation and Solar Activity since the Fifth Century BC and the Solar Cycle39
Rise of Robot Radiologists39
Protein-slaying drugs could be the next blockbuster therapies39
Why the sexes don’t feel pain the same way39
Machine-learning techniques used to accurately predict battery life39
Dynamic polymer network points the way to truly recyclable plastics39
Collective intercellular communication through ultra-fast hydrodynamic trigger waves39
Increased shear in the North Atlantic upper-level jet stream over the past four decades39
Absence of amorphous forms when ice is compressed at low temperature39
Location-level processes drive the establishment of alien bird populations worldwide39
It’s time to talk about ditching statistical significance38
Starfish enterprise: finding RNA patterns in single cells38
Workflow systems turn raw data into scientific knowledge38
Debating the bedrock of climate-change mitigation scenarios38
Histone lactylation links metabolism and gene regulation38
Credit data generators for data reuse38
An evolutionarily stable strategy to colonize spatially extended habitats38
Contrasting processes drive ophiuroid phylodiversity across shallow and deep seafloors38
Diversity decoupled from ecosystem function and resilience during mass extinction recovery38
Multivalent anions as universal latent electron donors38
Addendum: The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity38
Date of the Pliocene-Pleistocene Boundary in New Zealand37
Marine heatwaves in a changing climate37
Japan’s approval of stem-cell treatment for spinal-cord injury concerns scientists37
Chemosensory modulation of neural circuits for sodium appetite37
Correcting datasets leads to more homogeneous early-twentieth-century sea surface warming37
Directionality of dynein is controlled by the angle and length of its stalk37
Rethinking impact factors: better ways to judge a journal37
Measuring the Berry phase of graphene from wavefront dislocations in Friedel oscillations37
Rolling of the jaw is essential for mammalian chewing and tribosphenic molar function37
Author Correction: Human placenta has no microbiome but can contain potential pathogens37
Seismic velocities of CaSiO3 perovskite can explain LLSVPs in Earth’s lower mantle37
Long-period geomagnetic secular variations since 12,000 yr BP36
The growth of tea36
Cretaceous fossil reveals a new pattern in mammalian middle ear evolution36
Women from some under-represented minorities are given too few talks at world’s largest Earth-science conference36
Imaging work and dissipation in the quantum Hall state in graphene36
Electron pairing in the pseudogap state revealed by shot noise in copper oxide junctions36
Vast CO2 release from Australian fires in 2019–2020 constrained by satellite36
A new date for Ramapithecus35
Superconductivity seen in a non-magnetic nickel oxide35
Daytime colour preference in Drosophila depends on the circadian clock and TRP channels35
FPR1 is the plague receptor on host immune cells35
Publisher Correction: p53 regulation of ammonia metabolism through urea cycle controls polyamine biosynthesis35
The RIPK4–IRF6 signalling axis safeguards epidermal differentiation and barrier function35
Direct limits on the interaction of antiprotons with axion-like dark matter35
A powerful cell-protection system prevents cell death by ferroptosis34
Revisiting the cold case of cold fusion34
The super-cool materials that send heat to space34
Author Correction: Cyclin D–CDK4 kinase destabilizes PD-L1 via cullin 3–SPOP to control cancer immune surveillance34
Inner ear development in cyclostomes and evolution of the vertebrate semicircular canals34
A middle Cambrian arthropod with chelicerae and proto-book gills33
Fatty acids and cancer-amplified ZDHHC19 promote STAT3 activation through S-palmitoylation33
A decline in global CFC-11 emissions during 2018−201933
Nature’s reach: narrow work has broad impact32
A cool accretion disk around the Galactic Centre black hole32
The rheology and thermal history of Mars revealed by the orbital evolution of Phobos32
Glacial advance relative to volcanic activity since 1500 AD31
Precise date for the Laacher See eruption synchronizes the Younger Dryas31
Frequent observations of identical onsets of large and small earthquakes31
Where climate cash is flowing and why it’s not enough31
Reconstructing the late-accretion history of the Moon31
Wnt and TGFβ coordinate growth and patterning to regulate size-dependent behaviour31
Foot callus thickness does not trade off protection for tactile sensitivity during walking31
Automation: Chemistry shoots for the Moon30
How plants perceive salt30
Five ways China must cultivate research integrity30
Electromagnetic and gravitational responses of photonic Landau levels30
Milk of ruminants in ceramic baby bottles from prehistoric child graves30
Perfect Andreev reflection due to the Klein paradox in a topological superconducting state30
Mapping disparities in education across low- and middle-income countries30
Payouts push professors towards predatory journals29
Medicinal signalling cells: they work, so use them29
New antibiotics target the outer membrane of bacteria29
Hydropower dams can help mitigate the global warming impact of wetlands29
Imprinting sets the stage for speciation29
Concise asymmetric synthesis of (−)-bilobalide29
A strongly inhomogeneous superfluid in an iron-based superconductor29
Quantifying secondary transport at single-molecule resolution29
A NIK–SIX signalling axis controls inflammation by targeted silencing of non-canonical NF-κB29
Piezoelectric Effect in Poly-γ-methyl-L-glutamate28
Infrared variability of the BL lacertae object OJ287 since its outburst in 198328
The ethics of brain–computer interfaces28
The advent and rise of monoclonal antibodies28
Antibiotics set to flood Florida’s troubled orange orchards28
A fairer way forward for AI in health care28
Five innovative ways to use 3D printing in the laboratory28
Earth’s magnetic field is acting up and geologists don’t know why28
Interacting Floquet polaritons28
Neurocranial development of the coelacanth and the evolution of the sarcopterygian head28
Author Correction: Single-cell transcriptomic analysis of Alzheimer’s disease28
An Œstrogenic Substance in Pollen-grains of Date Palm Tree Phœnix dactylifera L., Palmæ27
Dry years in south-east England since 169827
The influence of solar forcing trends on global mean temperature since 186127
Hunting for New Drugs with AI27
A DIY approach to automating your lab27
Quantum gold rush: the private funding pouring into quantum start-ups27
Self-formed bedrock waterfalls27
Elastic colloidal monopoles and reconfigurable self-assembly in liquid crystals27
Magnetic monopole noise27
A warped disk around an infant protostar27