(The H4-Index of Nature is 244. The table below lists those papers that are above that threshold based on CrossRef citation counts. The publications cover those that have been published in the past four years, i.e., from 2019-03-01 to 2023-03-01.)
Ghrelin is a growth-hormone-releasing acylated peptide from stomach5971
Virological assessment of hospitalized patients with COVID-20194931
Quantum supremacy using a programmable superconducting processor2840
A role for ghrelin in the central regulation of feeding2476
Evolution of Asian monsoons and phased uplift of the Himalaya–Tibetan plateau since Late Miocene times1945
Search-and-replace genome editing without double-strand breaks or donor DNA1863
Efficient, stable and scalable perovskite solar cells using poly(3-hexylthiophene)1570
The single-cell transcriptional landscape of mammalian organogenesis1501
Next-generation characterization of the Cancer Cell Line Encyclopedia1495
Scientists rise up against statistical significance1450
Deep learning and process understanding for data-driven Earth system science1387
Multi-omics of the gut microbial ecosystem in inflammatory bowel diseases1151
Single-cell transcriptomic analysis of Alzheimer’s disease1069
The CoQ oxidoreductase FSP1 acts parallel to GPX4 to inhibit ferroptosis1036
Recycling lithium-ion batteries from electric vehicles1030
The clinical KRAS(G12C) inhibitor AMG 510 drives anti-tumour immunity998
FSP1 is a glutathione-independent ferroptosis suppressor996
Interannual extremes in the rate of rise of atmospheric carbon dioxide since 1980984
CD8+ T cells regulate tumour ferroptosis during cancer immunotherapy968
Grandmaster level in StarCraft II using multi-agent reinforcement learning911
A view on drug resistance in cancer869
Mapping the world’s free-flowing rivers865
Conserved cell types with divergent features in human versus mouse cortex849
Planar perovskite solar cells with long-term stability using ionic liquid additives841
One thousand plant transcriptomes and the phylogenomics of green plants830
Climate tipping points — too risky to bet against811
A rigorous electrochemical ammonia synthesis protocol with quantitative isotope measurements768
Transcriptome-scale super-resolved imaging in tissues by RNA seqFISH+751
Superconductors, orbital magnets and correlated states in magic-angle bilayer graphene746
Metabolic regulation of gene expression by histone lactylation736
Neoantigen vaccine generates intratumoral T cell responses in phase Ib glioblastoma trial728
The technological and economic prospects for CO2 utilization and removal708
Adjustment to climate change is constrained by arrival date in a long-distance migrant bird706
Evidence for moiré excitons in van der Waals heterostructures699
Prioritization of cancer therapeutic targets using CRISPR–Cas9 screens689
Van der Waals integration before and beyond two-dimensional materials672
Superconductivity at 250 K in lanthanum hydride under high pressures662
TOX transcriptionally and epigenetically programs CD8+ T cell exhaustion659
Graphene and two-dimensional materials for silicon technology642
Spatial and temporal heterogeneity of mouse and human microglia at single-cell resolution635
Signatures of moiré-trapped valley excitons in MoSe2/WSe2 heterobilayers631
PdMo bimetallene for oxygen reduction catalysis628
Quantifying inactive lithium in lithium metal batteries609
A new genomic blueprint of the human gut microbiota606
Genetic compensation triggered by mutant mRNA degradation597
All-optical spiking neurosynaptic networks with self-learning capabilities591
Resolving the fibrotic niche of human liver cirrhosis at single-cell level590
Supervised learning with quantum-enhanced feature spaces588
Observation of moiré excitons in WSe2/WS2 heterostructure superlattices588
Tuning element distribution, structure and properties by composition in high-entropy alloys586
Advances in epigenetics link genetics to the environment and disease581
Highly efficient and stable InP/ZnSe/ZnS quantum dot light-emitting diodes580
Importance and vulnerability of the world’s water towers576
A complete catalogue of high-quality topological materials568
Neutrophils escort circulating tumour cells to enable cell cycle progression564
The Integrative Human Microbiome Project558
A human liver cell atlas reveals heterogeneity and epithelial progenitors551
A defined commensal consortium elicits CD8 T cells and anti-cancer immunity544
NLRP3 inflammasome activation drives tau pathology542
Coral record of increased sediment flux to the inner Great Barrier Reef since European settlement535
Prediction and observation of an antiferromagnetic topological insulator521
Warming of the Antarctic ice-sheet surface since the 1957 International Geophysical Year519
Towards spike-based machine intelligence with neuromorphic computing519
Dry double-sided tape for adhesion of wet tissues and devices518
Genetic strategies for improving crop yields515
Arthropod decline in grasslands and forests is associated with landscape-level drivers502
TOX is a critical regulator of tumour-specific T cell differentiation498
CD24 signalling through macrophage Siglec-10 is a target for cancer immunotherapy497
Maximized electron interactions at the magic angle in twisted bilayer graphene496
Actively personalized vaccination trial for newly diagnosed glioblastoma495
Mapping human microbiome drug metabolism by gut bacteria and their genes493
Catalogue of topological electronic materials492
Genome-wide cell-free DNA fragmentation in patients with cancer492
Individual brain organoids reproducibly form cell diversity of the human cerebral cortex491
L1 drives IFN in senescent cells and promotes age-associated inflammation491
From discoveries in ageing research to therapeutics for healthy ageing489
Learning the signatures of the human grasp using a scalable tactile glove487
Widespread global increase in intense lake phytoplankton blooms since the 1980s486
Neoantigen-directed immune escape in lung cancer evolution480
Resonantly hybridized excitons in moiré superlattices in van der Waals heterostructures478
Anti-tumour immunity controlled through mRNA m6A methylation and YTHDF1 in dendritic cells476
A single-cell molecular map of mouse gastrulation and early organogenesis475
A clinically applicable approach to continuous prediction of future acute kidney injury475
Pan-cancer whole-genome analyses of metastatic solid tumours474
Electrical and synaptic integration of glioma into neural circuits473
Aqueous Li-ion battery enabled by halogen conversion–intercalation chemistry in graphite470
Voxelated soft matter via multimaterial multinozzle 3D printing466
Autophagy induction via STING trafficking is a primordial function of the cGAS pathway463
Global glacier mass changes and their contributions to sea-level rise from 1961 to 2016463
The bone marrow microenvironment at single-cell resolution459
Genetic analyses of diverse populations improves discovery for complex traits458
Superconductivity in an infinite-layer nickelate455
Domino electroreduction of CO2 to methanol on a molecular catalyst454
Changing climate both increases and decreases European river floods452
Bile acid metabolites control TH17 and Treg cell differentiation447
Molecular tuning of CO2-to-ethylene conversion444
Visualization and targeting of LGR5+ human colon cancer stem cells443
Unsupervised word embeddings capture latent knowledge from materials science literature438
Managing nitrogen to restore water quality in China438
Stunted microbiota and opportunistic pathogen colonization in caesarean-section birth435
TOX reinforces the phenotype and longevity of exhausted T cells in chronic viral infection427
Soil nematode abundance and functional group composition at a global scale418
Glutamatergic synaptic input to glioma cells drives brain tumour progression417
Skin-integrated wireless haptic interfaces for virtual and augmented reality417
Comprehensive search for topological materials using symmetry indicators416
The integrative biology of type 2 diabetes414
Novel tau filament fold in chronic traumatic encephalopathy encloses hydrophobic molecules413
Ultra-large library docking for discovering new chemotypes412
A national experiment reveals where a growth mindset improves achievement410
E-cadherin is required for metastasis in multiple models of breast cancer407
Distinct fibroblast subsets drive inflammation and damage in arthritis404
Proteomics identifies new therapeutic targets of early-stage hepatocellular carcinoma404
Earliest date for milk use in the Near East and southeastern Europe linked to cattle herding403
MHC-II neoantigens shape tumour immunity and response to immunotherapy403
New insights from uncultivated genomes of the global human gut microbiome402
Intercellular interaction dictates cancer cell ferroptosis via NF2–YAP signalling392
Changes in oceanic and terrestrial carbon uptake since 1982391
Additive manufacturing of ultrafine-grained high-strength titanium alloys389
Microbial bile acid metabolites modulate gut RORγ+ regulatory T cell homeostasis389
Human placenta has no microbiome but can contain potential pathogens388
Mapping the human genetic architecture of COVID-19387
Altered human oligodendrocyte heterogeneity in multiple sclerosis386
Van der Waals contacts between three-dimensional metals and two-dimensional semiconductors386
The global distribution and trajectory of tidal flats385
Charge order and broken rotational symmetry in magic-angle twisted bilayer graphene384
Whole-animal connectomes of both Caenorhabditis elegans sexes380
Drift of the major continental blocks since the Devonian378
Caspase-8 is the molecular switch for apoptosis, necroptosis and pyroptosis372
Complete biosynthesis of cannabinoids and their unnatural analogues in yeast369
Speech synthesis from neural decoding of spoken sentences368
Human blood vessel organoids as a model of diabetic vasculopathy368
Machine behaviour368
Age-related remodelling of oesophageal epithelia by mutated cancer drivers368
NR4A transcription factors limit CAR T cell function in solid tumours367
Scalable energy-efficient magnetoelectric spin–orbit logic364
Restoring natural forests is the best way to remove atmospheric carbon355
Spectroscopic signatures of many-body correlations in magic-angle twisted bilayer graphene355
Signatures of tunable superconductivity in a trilayer graphene moiré superlattice353
Organoid single-cell genomic atlas uncovers human-specific features of brain development353
The landscape of somatic mutation in normal colorectal epithelial cells353
Error mitigation extends the computational reach of a noisy quantum processor352
Genomic characterization of metastatic breast cancers352
Nitrosative stress drives heart failure with preserved ejection fraction351
Bacteriophage targeting of gut bacterium attenuates alcoholic liver disease351
Harnessing innate immunity in cancer therapy350
Modern microprocessor built from complementary carbon nanotube transistors350
Rising rural body-mass index is the main driver of the global obesity epidemic in adults347
Structural basis of STING binding with and phosphorylation by TBK1345
Broadband electro-optic frequency comb generation in a lithium niobate microring resonator343
Photoredox catalysis using infrared light via triplet fusion upconversion341
Dissociable dopamine dynamics for learning and motivation341
Magnitude of urban heat islands largely explained by climate and population340
Heterochromatin drives compartmentalization of inverted and conventional nuclei340
HIV-1 remission following CCR5Δ32/Δ32 haematopoietic stem-cell transplantation340
Gene expression across mammalian organ development340
Pol II phosphorylation regulates a switch between transcriptional and splicing condensates338
An intra-tumoral niche maintains and differentiates stem-like CD8 T cells338
Transcriptome-wide off-target RNA editing induced by CRISPR-guided DNA base editors337
c-Jun overexpression in CAR T cells induces exhaustion resistance336
Deep learning for multi-year ENSO forecasts332
Structural mechanism for NEK7-licensed activation of NLRP3 inflammasome332
Towards artificial general intelligence with hybrid Tianjic chip architecture332
A quantitative approach for measuring the reservoir of latent HIV-1 proviruses332
m6A enhances the phase separation potential of mRNA330
Colonic epithelial cell diversity in health and inflammatory bowel disease330
Brain regulatory T cells suppress astrogliosis and potentiate neurological recovery329
Atomically dispersed iron hydroxide anchored on Pt for preferential oxidation of CO in H2329
Normal faulting in central Tibet since at least 13.5 Myr ago324
Histone H3 trimethylation at lysine 36 guides m6A RNA modification co-transcriptionally324
The fungal mycobiome promotes pancreatic oncogenesis via activation of MBL321
Loss of ADAR1 in tumours overcomes resistance to immune checkpoint blockade321
Potential roles of gut microbiome and metabolites in modulating ALS in mice320
Incompatible and sterile insect techniques combined eliminate mosquitoes313
Epitaxial growth of a 100-square-centimetre single-crystal hexagonal boron nitride monolayer on copper310
A new antibiotic selectively kills Gram-negative pathogens309
Committed emissions from existing energy infrastructure jeopardize 1.5 °C climate target308
Superstructure control of first-cycle voltage hysteresis in oxygen-redox cathodes307
Genomic encoding of transcriptional burst kinetics306
Commonality despite exceptional diversity in the baseline human antibody repertoire303
Transposon-encoded CRISPR–Cas systems direct RNA-guided DNA integration303
Meningeal lymphatic vessels at the skull base drain cerebrospinal fluid300
Highly structured slow solar wind emerging from an equatorial coronal hole299
Self-verifying variational quantum simulation of lattice models297
Fatty acid transport protein 2 reprograms neutrophils in cancer297
Observation of room-temperature polar skyrmions297
GABAA receptor signalling mechanisms revealed by structural pharmacology296
Dietary methionine influences therapy in mouse cancer models and alters human metabolism295
Organization and regulation of gene transcription294
Multi-faceted particle pumps drive carbon sequestration in the ocean294
Greater vulnerability to warming of marine versus terrestrial ectotherms292
Mass balance of the Greenland Ice Sheet from 1992 to 2018292
The unexpected surface of asteroid (101955) Bennu292
Millennial-scale trends in west Pacific warm pool hydrology since the Last Glacial Maximum291
Large teams develop and small teams disrupt science and technology290
Visualizing vibrational normal modes of a single molecule with atomically confined light290
Decoding human fetal liver haematopoiesis290
Damage-tolerant architected materials inspired by crystal microstructure288
Controlled flight of a microrobot powered by soft artificial muscles286
Distributed coding of choice, action and engagement across the mouse brain285
Longitudinal multi-omics of host–microbe dynamics in prediabetes285
45.5-tesla direct-current magnetic field generated with a high-temperature superconducting magnet284
An acute immune response underlies the benefit of cardiac stem cell therapy281
Global warming impairs stock–recruitment dynamics of corals278
Data-driven design of metal–organic frameworks for wet flue gas CO2 capture278
Targeting cardiac fibrosis with engineered T cells275
Charting cellular identity during human in vitro β-cell differentiation274
Harnessing global fisheries to tackle micronutrient deficiencies273
CAR T cell trogocytosis and cooperative killing regulate tumour antigen escape272
PTC-bearing mRNA elicits a genetic compensation response via Upf3a and COMPASS components271
De novo design of potent and selective mimics of IL-2 and IL-15270
The human body at cellular resolution: the NIH Human Biomolecular Atlas Program270
Large influence of soil moisture on long-term terrestrial carbon uptake269
Hierarchical organization of cortical and thalamic connectivity269
Climatic controls of decomposition drive the global biogeography of forest-tree symbioses268
HP1 reshapes nucleosome core to promote phase separation of heterochromatin267
Self-organization and symmetry breaking in intestinal organoid development267
A wireless closed-loop system for optogenetic peripheral neuromodulation267
Tracking tumour evolution in glioma through liquid biopsies of cerebrospinal fluid267
Freestanding crystalline oxide perovskites down to the monolayer limit266
Decrease in anthropogenic lead, cadmium and zinc in Greenland snows since the late 1960s265
Cryo-EM structures of STING reveal its mechanism of activation by cyclic GMP–AMP265
Transcription factors and 3D genome conformation in cell-fate decisions264
High-dimensional geometry of population responses in visual cortex264
Specialized coding of sensory, motor and cognitive variables in VTA dopamine neurons263
Off-target RNA mutation induced by DNA base editing and its elimination by mutagenesis263
Intestinal infection triggers Parkinson’s disease-like symptoms in Pink1−/− mice263
CasX enzymes comprise a distinct family of RNA-guided genome editors263
Asia’s shrinking glaciers protect large populations from drought stress261
Site-selective and versatile aromatic C−H functionalization by thianthrenation261
MicroRNA therapy stimulates uncontrolled cardiac repair after myocardial infarction in pigs260
A distance to the Large Magellanic Cloud that is precise to one per cent260
Total synthesis of Escherichia coli with a recoded genome259
Neuronal vulnerability and multilineage diversity in multiple sclerosis258
Locally renewing resident synovial macrophages provide a protective barrier for the joint257
Observation of the nonlinear Hall effect under time-reversal-symmetric conditions256
Mitochondrial complex III is essential for suppressive function of regulatory T cells255
Cyclic GMP–AMP signalling protects bacteria against viral infection250
Visualizing DNA folding and RNA in embryos at single-cell resolution247
Plant cell-surface GIPC sphingolipids sense salt to trigger Ca2+ influx247
Controlled modelling of human epiblast and amnion development using stem cells246
The histone mark H3K36me2 recruits DNMT3A and shapes the intergenic DNA methylation landscape246
Single-cell analysis reveals T cell infiltration in old neurogenic niches245
Molybdenum-catalysed ammonia production with samarium diiodide and alcohols or water244
Environmental flow limits to global groundwater pumping244