Proceedings of the National Academy of Sciences of the United States o

Article	Citations
Greener skies? The quest for sustainable flying	763
Profile of Johannes Lehmann	531
Functional genomics analysis reveals the evolutionary adaptation and demographic history of pygmy lorises	455
Industrial-era decline in Arctic methanesulfonic acid is offset by increased biogenic sulfate aerosol	415
Probing the connection between chirality and spin through time-resolved EPR spectroscopy	403
Optimal transitions between nonequilibrium steady states	386
Yeast centrosomes act as organizing centers to promote Polo kinase–mediated adaptation to persistent DNA damage	376
Thermoelectricity, metallic liquidity, and magnetohydrodynamics	366
Reply to Apanovich and Weeks: Exceptions exist, as recognized in the paper, but are too rare to challenge the original findings	362
Slope classicality in higher Coleman theory via highest weight vectors in completed cohomology	360
Kids adopt different ways of coping in wake of the pandemic	329
Reply to Kodner et al.: Fundamental misunderstanding of both model and methods	324
The tumor suppressor RASSF8: A WAVE interaction partner controlling migration and cohesion of invasive border cells in Drosophila	314
In This Issue	311
How can we reform the STEM tenure system for the 21st Century?	305
In This Issue	305
Wandering mastodons reveal the complexity of Ice Age extinctions	295
Individuals benefit individual out-group members rather than harm in-group members	277
Mercury’s complex legacy	267
Endurance athletes hiding in plain sight in the high Andes	263
Late Cretaceous community structure changed before the asteroid	258
Impression management in research reporting: When effects are not really as pronounced as claimed	257
SARS-CoV-2-derived RNA replicons as safe and effective vaccines	251
Adaptive cooling strategy via human hair: High optothermal conversion efficiency of solar radiation into thermal dissipation	250
In This Issue	233

Quantitative comparison of nuclear transport inhibition by SARS coronavirus ORF6 reveals the importance of oligomerization	233
Cytosolic and mitochondrial ribosomal proteins mediate the locust phase transition via divergence of translational profiles	230
High UV damage and low repair, but not cytosine deamination, stimulate mutation hotspots at ETS binding sites in melanoma	228
How defective mitochondrial electrical activity leads to inherited blindness	225
An accurate cellular assay to determine pathogenicity of coding and noncoding variants in Lynch syndrome genes	224
Towards CRISPR-based editing of the mitochondrial genome in yeast	224
The intracellular Ca2+channel TRPML3 is a PI3P effector that regulates autophagosome biogenesis	222
The Titanic question in TB control: Should we worry about the bummock?	217
Keystone predator and keystone intransitivity and the rescue of a competitively subdominant species	213
Phantom sinks and missing pollution: Legacies of a hardened number	209
Regulation of Na/Ca exchange by cytoplasmic protons modifies intracellular calcium dynamics and the cardiac response to ischemia	203
Circadian clock control of interactions between eIF2α kinase CPC-3 and GCN1 with ribosomes regulates rhythmic translation initiation	199
Probing both sides of the story	196
Testing whether connectivity stabilizes metacommunities and rescues declining diversity in a 25-y grassland study	192
Advancing stochastic 3-SAT solvers by dissipating oversatisfied constraints	188
Nitrogen-fixing microbes gain genes in diverse types of living environments	188
Stochastically evolving graphs via edit semigroups	187
The lysosomal carrier SLC29A3 supports antibacterial signaling, and promotes autophagy by activating TRPML1 in murine dendritic cells	185
Antiprion systems in yeast cooperate to cure or prevent the generation of nearly all [ PSI + ] and [URE3] prions	184
Revealing the structure of snowflakes using acoustic levitation	182
Structure of the Thomasclavelia ramosa immunoglobulin A protease reveals a modular and minimizable architecture distinct from other immunoglobulin A proteases	182
A degradable form of polyoma small T antigen reveals the high specificity of TAZ in regulating gene expression	182
Proprioceptive feedback amplification restores effective locomotion in a neuromechanical model of lampreys with spinal injuries	180
Contraception ends the genetic maintenance of human same-sex sexual behavior	175
Multispecies sensory networks and social foraging strategies: Implications for population decline in procellariiform seabirds	175
Emergent behaviors of buckling-driven elasto-active structures	173
Engineered bacteria that self-assemble bioglass polysilicate coatings display enhanced light focusing	170
Ru-P pair sites boost charge transport in hematite photoanodes for exceeding 1% efficient solar water splitting	170
Identification of potent pan-ephrin receptor kinase inhibitors using DNA-encoded chemistry technology	166
Hypoxia inducible factors regulate pneumovirus replication by enhancing innate immune sensing	163
GmEID1 modulates light signaling through the Evening Complex to control flowering time and yield in soybean	163
Multiple dimeric structures and strand-swap dimerization of E-cadherin in solution visualized by high-speed atomic force microscopy	162
Social stressors associated with age-related T lymphocyte percentages in older US adults: Evidence from the US Health and Retirement Study	162
RIPK1 ubiquitination regulates its kinase-independent function in development and inflammation	159
The Nemp1–Nesprin complex mediates cellular responses to matrix mechanics	156
A TIAM1-TRIM28 complex mediates epigenetic silencing of protocadherins to promote migration of lung cancer cells	155
Identification of cap-dependent endonuclease inhibitors with broad-spectrum activity against bunyaviruses	153
Unproctored online exams provide meaningful assessment of student learning	152
Mafba and Mafbb regulate microglial colonization of zebrafish brain via controlling chemotaxis receptor expression	152
Parameters of clustered suboptimal miRNA biogenesis	152
ASB9 promotes ubiquitin-mediated degradation of TNP2 to facilitate histone-to-protamine transition in humans and mice	151
Spirocyclic β-lactone secondary metabolites modulate spliceosome function	149
Chronic infection perturbs the affinity hierarchy of antiviral B cells	149
β-catenin turnover is regulated by Nek10-mediated tyrosine phosphorylation in A549 lung adenocarcinoma cells	148
Proton-activated chloride channel 1 is essential for innate host defense against bacterial sepsis	146
Glucuronic acid confers colonization advantage to enteric pathogens	146
Band gap opening of metallic single-walled carbon nanotubes via noncovalent symmetry breaking	145
The gender gap in the ownership of promising land	144
Model evidence for distinct origins of glacial–interglacial and millennial signals in Greenland dust	143
Touching the classical scaling in penetrative convection	143

Identifying regulation with adversarial surrogates	142
Topography affects not only interhemispheric asymmetry of westerly winds and thus storminess but also ocean circulation	142
Conservation management strategy impacts inbreeding and mutation load in scimitar-horned oryx	141
Tsg101 mimicry of canonical E2 enzymes underlies its role in ubiquitin signaling	141
Schnurri-3 inhibition suppresses bone and joint damage in models of rheumatoid arthritis	141
Centuries of compounding human influence on Amazonian forests	141
Architecture-driven quantitative nanoscopy maps cytoskeleton remodeling	139
Deep silicification–assisted long-term preservation of structural and genomic information across biospecies: From micro to macro	138
ERK and c-Myc signaling in host-derived tumor endothelial cells is essential for solid tumor growth	138
Strong connectivity in real directed networks	137
Genome-wide detection of human variants that disrupt intronic branchpoints	135
Symmetries and synchronization from whole-neural activity in the Caenorhabditis elegans connectome: Integration of functional and structural networks	135
Systemic Kras ablation disrupts myeloid cell homeostasis in adult mice	134
Dynamics of memory B cells and plasmablasts in healthy individuals	134
Single hormone or synthetic agonist induces Gs/Gicoupling selectivity of EP receptors via distinct binding modes and propagating paths	134
Lysosome-related organelles orchestrate guanine crystal formation in pigment cells	133
Resilience of deep aquifer microbial communities to seasonal hydrological fluctuations	133
DNA methylation shapes transcription factor binding beyond canonical CpG contexts	132
Wild food portfolios: Access to diverse foods stabilizes harvest in wild food systems	131
Acclimation to high and low diurnal light is flexible in Chlamydomonas reinhardtii	131
Pathogen dilution, resource partitioning, and precipitation generate productivity benefits from plant diversity	131
Retraction for Li et al., Synthetic lethality of combined glutaminase and Hsp90 inhibition in mTORC1-driven tumor cells	130
Designing the stripe-ordered cuprate phase diagram through uniaxial-stress	130
Correction for Andreasson et al., Crowdsourced RNA design discovers diverse, reversible, efficient, self-contained molecular switches	129
Correction for Li et al., SARS-CoV-2 induces double-stranded RNA-mediated innate immune responses in respiratory epithelial-derived cells and cardiomyocytes	128
Correction for Dar et al., Bromodomain inhibition overcomes treatment resistance in distinct molecular subtypes of melanoma	128
Correction to Gaffney et al., Lipid bilayer induces contraction of the denatured state ensemble of a helical-bundle membrane protein	127
Structural stability and thermodynamics of artistic composition	127
Correction for Ahituv et al., Starch-rich plant foods 780,000 y ago: Evidence from Acheulian percussive stone tools	126
Correction for Magesh et al., Co-zorbs: Motile, multispecies biofilms aid transport of diverse bacterial species	126
Correction for Garaizar et al., Toward understanding lipid reorganization in RNA lipid nanoparticles in acidic environments	125
Retraction for Goswami et al., A bifunctional tRNA import receptor from Leishmania mitochondria	125
Correction to Supporting Information for Ikeda et al., Seesaw protein: Design of a protein that adopts interconvertible alternative functional conformations and its dynamics	125
Correction to Supporting Information for Bardy et al., Neuronal medium that supports basic synaptic functions and activity of human neurons in vitro	125
Correction for Wang et al., Interplay of mevalonate and Hippo pathways regulates RHAMM transcription via YAP to modulate breast cancer cell motility	124
Correction for Dong et al., Hybridoma-inspired strategy crafts tailored multifunctional exosomes for precision therapy	123
Cell numbers contribute to cell fate during Ciona cardiopharyngeal mesoderm specification	123
Correction for Mittal et al., Mechanisms underlying allosteric modulation of antiseizure medication binding to synaptic vesicle protein 2A (SV2A)	123
Untangling the CD4 T cell response to the microbiota	123
Correction for Wurman et al., Supercell tornadoes are much stronger and wider than damage-based ratings indicate	123
Host–microbiome mutualism drives urea carbon salvage and acetogenesis during hibernation	122
Multiscale modeling shows how 2’-deoxy-ATP rescues ventricular function in heart failure	122
In This Issue	122
Bioresponsive immunomodulator nanocomplex for selective immunoengineering in metastatic lymph nodes	121
Inhibition of GPR39 restores defects in endothelial cell–mediated neovascularization under the duress of chronic hyperglycemia: Evidence for regulatory roles of the sonic hedgehog signaling axis	121
Pseudogap in electron-doped cuprates: Strong correlation leading to band splitting	121
Correlated substitutions reveal SARS-like coronaviruses recombine frequently with a diverse set of structured gene pools	121
Fluorescence detection of dopamine signaling to the primate striatum in relation to stimulus–reward associations	121
Identification of KU-55933 as an anti-atherosclerosis compound by using a hemodynamic-based high-throughput drug screening platform	120
Kinetic pathways of solid–solid phase transitions dictated by short-range interactions	119
Structural basis for severe pain caused by mutations in the S4-S5 linkers of voltage-gated sodium channel Na V 1.7	119
Strategy to develop broadly effective multivalent COVID-19 vaccines against emerging variants based on Ad5/35 platform	118
Part of the gender gap in voting for Democrats arises because a higher proportion of women than men voters are Black	118
Grazer exclusion is associated with higher fast-cycling carbon pools but lower slow-cycling mineral-associated carbon across grasslands	117
From relaxation to buckling: A continuum elastic framework connecting surface instabilities of highly compressed lipid thin films	116
Upper mantle temperatures illuminate the Iceland hotspot track and understanding of ice–Earth interactions in Greenland	116
Breaking the symmetry of cell contractility drives tubulogenesis via CXCL1 polarization	116
The James Webb Space Telescope prompts a rethink of how galaxies form	116
IL-1 receptor antagonism reveals a yin-yang relationship between NFκB and interferon signaling in chronic lymphocytic leukemia	115
PTP1B inhibition promotes microglial phagocytosis in Alzheimer’s disease models by enhancing SYK signaling	115
A neuron–astrocyte signaling axis in the ACC sustains diabetic neuropathic pain	115
Human ERG oncoprotein represses a Drosophila LIM domain binding protein–coding gene Chip	114
A multilocus perspective on the evolutionary dynamics of multistrain pathogens	114
Using neuroimaging genomics to investigate the evolution of human brain structure	113
Maple samaras recover autorotation following raindrop collisions	113
Regulation of the immune CD155–CD226–TIGIT axis by cyclin D-CDK4/6	113
Linker histone regulates the myeloid versus lymphoid bifurcation of multipotent hematopoietic stem and progenitors	113
Thermo-photo catalytic anode process for carbonate-superstructured solid fuel cells	113
Distinct impact of PI(4)P flux on PI(4,5)P 2 steady states and oscillations	112
Identification of AK4 and RHOC as potential oncogenes addicted by adult T cell leukemia	112
Dominance of felsic continental crust on Earth after 3 billion years ago is recorded by vanadium isotopes	111
Heparin is essential for optimal cell signaling by FGF21 and for regulation of βKlotho cellular stability	111
The structure of Plasmodium falciparum multidrug resistance protein 1 reveals an N-terminal regulatory domain	111
Wolves fear humans but learn quickly about us	110
CoRa—A general approach for quantifying biological feedback control	109
Diets, dominance hierarchies, and kleptoparasitism drive asymmetrical interactions between wolves and cougars	109
Memory’s gatekeeper: The role of PFC in the encoding of congruent events	109
Skillful heat-related mortality forecasting during recent deadly European summers	109
Hidden in plain sight: (Re)definition of a key lepidopteran color patterning gene	109
CD83 suppresses endogenous March-I-dependent MHC class II ubiquitination, endocytosis, and degradation	108

The m5C orchestrator NSUN7 drives SPARC/HMGB1 axis–mediated inflammation to exacerbate kidney injury	108
Ride-hailing technology mitigates effects of driver racial discrimination, but effects of residential segregation persist	108
Caspase-8 and FADD prevent spontaneous ZBP1 expression and necroptosis	107
Structural basis of higher order oligomerization of KSHV inhibitor of cGAS	107
The power of coalescent methods for inferring recent and ancient gene flow in endangered Bactrian camels	107
The importance of elders: Extending Hamilton’s force of selection to include intergenerational transfers	106
On peer review—then, now, and soon to be?	106
Decoding antibody response to MERS-CoV in wild dromedary camels	106
Revealing land control dynamics in emerging agricultural frontiers	105
Subcellular activation of β-adrenergic receptors using a spatially restricted antagonist	105
More social interactions, more polarization? The evidence is not there	105
Systemic deletion of DMD exon 51 rescues clinically severe Duchenne muscular dystrophy in a pig model lacking DMD exon 52	105
ACSS2 upregulation enhances neuronal resilience to aging and tau-associated neurodegeneration	104
A metabolic cell death program downstream of SARM1 couples NAD + depletion to BAX activation and APAF1 degradation	104
An HLA-E-targeted TCR bispecific molecule redirects T cell immunity against Mycobacterium tuberculosis	104
Proactive or reactive? Neural oscillatory insight into the leader–follower dynamics of early infant–caregiver interaction	104
Stepwise activation of SARM1 for cell death and axon degeneration revealed by a biosynthetic NMN mimic	104
Propulsive cell entry diverts pathogens from immune degradation by remodeling the phagocytic synapse	103
Investigating 3D microbial community dynamics of the rhizosphere using quantitative phase and fluorescence microscopy	103
The quorum-sensing peptidic inhibitor rescues host immune system eradication: A novel infectivity mechanism	103
Molecular basis of hemoglobin binding and heme removal in Corynebacterium diphtheriae	103
Pressure pushes tRNA Lys3 into excited conformational states	103
A bipartite interaction with the processivity clamp potentiates Pol IV-mediated TLS	102
Specialization of the photoreceptor transcriptome by Srrm3 -dependent microexons is required for outer segment maintenance and vision	102
Alternative cGAS signaling promotes herpes simplex encephalitis	102
Malaria parasite evades mosquito immunity by glutaminyl cyclase–mediated posttranslational protein modification	102
Heterogenous biofilm mass-transport model replicates periphery sequestration of antibiotics in Pseudomonas aeruginosa PAO1 microcolonies	102
Independent transitions to fully planktonic life cycles shaped the global distribution of medusozoans in the epipelagic zone	102
Roughness-dependent scaling of the contact area and separation gap with pressure for glassy polymers	101
Methodological and conceptual considerations of the TCM evolution	101
Extremal structures with embedded prefailure indicators	101
Gap junction–transported cAMP from the niche controls stem cell progeny differentiation	101
PD-1 expression identifies proliferating malignant CLL B cells and is a potential biomarker of response to BTK inhibitor therapy	100
Competing gauge fields and entropically driven spin liquid to spin liquid transition in non-Kramers pyrochlores	100
Abdominal ultrasound activates afferent vagus nerve fibers and induces anti-inflammatory effects	100
HLA-B*15:01-positive severe COVID-19 patients lack CD8 + T cell pools with highly expanded public clonotypes	99
Concerted evolution of metabolic rate, economics of mating, ecology, and pace of life across seed beetles	99
Rewinding evolution in planta: A Rubisco-null platform validates high-performance ancestral enzymes	99
Conserving rhinoceros in the face of disease	99
Tetrapod species–area relationships across the Cretaceous–Paleogene mass extinction	98
Evolutionary trade-offs under stochastic water stress shape xylem vulnerability to drought	98
The evidence remains clear: SARS-CoV-2 emerged via the wildlife trade	98
Correction for Lee et al., Saccade-related LFP power transients in the primate amygdala and hippocampus linked to the perception of social status	97
Synergetic collision and space separation in microfluidic chip for efficient affinity-discriminated molecular selection	97
Distinct neural networks derived from galanin-containing nociceptors and neurotensin-expressing pruriceptors	97
MondoA mediates transcriptional coordination between the MYC network and the integrated stress response in pancreatic cancer	97
Data-driven classification of ligand unbinding pathways	97
Differential elimination of marked sex chromosomes enables production of nontransgenic male mosquitoes in a single strain	97
Reversible acetylation of Hpo regulates the Hippo pathway	96
Aerophilic debubbling	96
Reassessing evidence for symmetric histone inheritance in Drosophila stem cells	96
State-dependent motion of a genetically encoded fluorescent biosensor	96
The adhesion GPCR ADGRL2 engages Gα13 to enable epidermal differentiation	96
Temperature and sex ratios at birth	96
Altermagnetic polar metallic phase in ultrathin epitaxially strained RuO 2 films	96
Magnetic soft microrobots for erectile dysfunction therapy	95
Identification, structural, and biophysical characterization of a positive modulator of human Kv3.1 channels	95
Molecular patterns of matrix protein 1 (M1): A strong predictor of adaptive evolution in H9N2 avian influenza viruses	95
Vulnerability to natural disasters and sustainable consumption: Unraveling political and regional differences	95
Accurate identification and mechanistic evaluation of pathogenic missense variants with Rhapsody-2	95
A heritable iron memory enables decision-making in Escherichia coli	95
NOTUM-mediated WNT silencing drives extravillous trophoblast cell lineage development	94
The role of the tryptophan-rich allosteric network and sodium egress in GPCR activation	94
Restoring neuronal iron homeostasis revitalizes neurogenesis after spinal cord injury	94
Croquemort elicits activation of the immune deficiency pathway in ticks	94
Observing heroic behavior and its influencing factors in immersive virtual environments	93
Assessing cerebral capillary function and stalling using single capillary reporters in ultrasound localization microscopy	93
BRD9 functions as an HIV-1 latency regulatory factor	93
Computationally efficient whole-genome quantile regression at biobank scale	93
Two-pore channels regulate endomembrane tension to enable remodeling and resolution of phagolysosomes	93
Lysosomal glucocerebrosidase is needed for ciliary Hedgehog signaling: A convergent pathway contributing to Parkinson’s disease	93
Arabidopsis protein S -acyl transferases positively mediate BR signaling through S -acylation of BSK1	93
Targeting spike glycans to inhibit SARS-CoV2 viral entry	92
Accelerating diabetic wound healing by ROS-scavenging lipid nanoparticle–mRNA formulation	92
Lattice materials with topological states optimized on demand	92
Indigenous territories and protected areas are crucial for ecosystem connectivity in the Amazon basin	92
Dual-inhibitory domain iCARs improve the efficiency of the AND-NOT gate CAR T strategy	92
MBD2a–NuRD binds to the methylated γ-globin gene promoter and uniquely forms a complex required for silencing of HbF expression	92
Sound-mediated nucleation and growth of amyloid fibrils	91
TEX38 localizes ZDHHC19 to the plasma membrane and regulates sperm head morphogenesis in mice	91
Data-driven particle dynamics: Structure-preserving coarse-graining for emergent behavior in nonequilibrium systems	91
Soft, skin-interfaced electronics enable cannula-free wireless monitoring of sleep respiration	90
Long-term employment and health effects of active labor market programs	90
Identification of two archaeal GDGT lipid–modifying proteins reveals diverse microbes capable of GMGT biosynthesis and modification	90
Nutrient-derived signals regulate eosinophil adaptation to the small intestine	90
Cytoplasmic stirring by active carpets	90
Mitochondria regulate MR1 protein expression and produce self-metabolites that activate MR1-restricted T cells	89
Atomic resolution structure of full-length human insulin fibrils	89
Directional water navigation and reallocation in Tillandsia capitata	89
Phylogenetic evidence clarifies the history of the extrusion of Indochina	89
Cell cycle plasticity underlies fractional resistance to palbociclib in ER+/HER2− breast tumor cells	89
Oligopoly competition between satellite constellations will reduce economic welfare from orbit use	89
Inversion of pop-out for a distracting feature dimension in monkey visual cortex	89
Emotional (in)stability: Neuroticism is associated with increased variability in negative emotion after all	88
Compositionality and systematicity emerge from iterated learning in deep linear networks	87