OOIR: Observatory of International Research

Papers

(The median citation count of Proceedings of the National Academy of Sciences of the United States o is 7. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-10-01 to 2025-10-01.)

Article	Citations
Crosslinguistic word order variation reflects evolutionary pressures of dependency and information locality	1017
Thalamocortical axons regulate neurogenesis and laminar fates in the early sensory cortex	682
The quorum-sensing peptidic inhibitor rescues host immune system eradication: A novel infectivity mechanism	546
Healthy sleep durations appear to vary across cultures	491
Contraception ends the genetic maintenance of human same-sex sexual behavior	451
Multiscale modeling shows how 2’-deoxy-ATP rescues ventricular function in heart failure	442
SCoTCH-seq reveals that 5-hydroxymethylcytosine encodes regulatory information across DNA strands	437
A bacterial pigment provides cross-species protection from H ₂ O ₂ - and neutrophil-mediated killing	406
Data-driven classification of ligand unbinding pathways	403
Lateral olivocochlear neurons modulate cochlear responses to noise exposure	390
The gender gap in the ownership of promising land	370
Topography affects not only interhemispheric asymmetry of westerly winds and thus storminess but also ocean circulation	341
Systemic Kras ablation disrupts myeloid cell homeostasis in adult mice	335
A bipartite interaction with the processivity clamp potentiates Pol IV-mediated TLS	330
Pseudogap in electron-doped cuprates: Strong correlation leading to band splitting	303
Photovoltaic effect by soft phonon excitation	302
The power of coalescent methods for inferring recent and ancient gene flow in endangered Bactrian camels	297
Designing the stripe-ordered cuprate phase diagram through uniaxial-stress	283
Ultrafast atomic view of laser-induced melting and breathing motion of metallic liquid clusters with MeV ultrafast electron diffraction	276
Controlling laser-dressed resonance line shape using attosecond extreme-ultraviolet pulse with a spectral minimum	269
The pathogenic T42A mutation in SHP2 rewires the interaction specificity of its N-terminal regulatory domain	265
Quantifying the impact of air pollution from coal-fired electricity generation on crop productivity in India	259
Industrial-era decline in Arctic methanesulfonic acid is offset by increased biogenic sulfate aerosol	257
Tumor-polarized GPX3 ⁺ AT2 lung epithelial cells promote premetastatic niche formation	251
Lattice materials with topological states optimized on demand	248

Autophagy activator AA-20 improves proteostasis and extends Caenorhabditis elegans lifespan	247
Keystone predator and keystone intransitivity and the rescue of a competitively subdominant species	243
Phase separation in mitochondrial fate and mitochondrial diseases	237
Functional genomics analysis reveals the evolutionary adaptation and demographic history of pygmy lorises	236
A TIAM1-TRIM28 complex mediates epigenetic silencing of protocadherins to promote migration of lung cancer cells	233
Hippo-TAZ signaling is the master regulator of the onset of triple-negative basal-like breast cancers	232
Extremal structures with embedded prefailure indicators	231
A conserved ARF–DNA interface underlies auxin-triggered transcriptional response	227
Synergetic collision and space separation in microfluidic chip for efficient affinity-discriminated molecular selection	225
Magnetic soft microrobots for erectile dysfunction therapy	223
Structure of the Thomasclavelia ramosa immunoglobulin A protease reveals a modular and minimizable architecture distinct from other immunoglobulin A proteases	222
Minority salience and the overestimation of individuals from minority groups in perception and memory	221
The structure of Plasmodium falciparum multidrug resistance protein 1 reveals an N-terminal regulatory domain	214
Tetrapod species–area relationships across the Cretaceous–Paleogene mass extinction	213
Autophagy induced by taurolidine protects against polymicrobial sepsis by promoting both host resistance and disease tolerance	212
Assembly-enhanced recognition: A biomimetic pathway to achieve ultrahigh affinities	208
Profile of Johannes Lehmann	201
Emergent behaviors of buckling-driven elasto-active structures	201
Weakening AMOC reduces ocean carbon uptake and increases the social cost of carbon	200
The ubiquitous microtubule-associated protein 4 (MAP4) controls organelle distribution by regulating the activity of the kinesin motor	200
Ablation of lysophosphatidic acid receptor 1 attenuates hypertrophic cardiomyopathy in a mouse model	197
ERK and c-Myc signaling in host-derived tumor endothelial cells is essential for solid tumor growth	195
Structural basis for severe pain caused by mutations in the S4-S5 linkers of voltage-gated sodium channel Na _V 1.7	194
Differential elimination of marked sex chromosomes enables production of nontransgenic male mosquitoes in a single strain	194
GmEID1 modulates light signaling through the Evening Complex to control flowering time and yield in soybean	193
Peroxisomal metabolic coupling improves fatty alcohol production from sole methanol in yeast	190
Temporal and spatial distribution of health, labor, and crop benefits of climate change mitigation in the United States	187
Inhibition of GPR39 restores defects in endothelial cell–mediated neovascularization under the duress of chronic hyperglycemia: Evidence for regulatory roles of the sonic hedgehog signaling axis	185
From the laboratory to the consumer: Innovation, supply chain, and adoption with applications to natural resources	184
The new W family reconstructs the evolution of MHC genes	177
Transforming growth factor-β signaling governs the differentiation program of extravillous trophoblasts in the developing human placenta	177
Schnurri-3 inhibition suppresses bone and joint damage in models of rheumatoid arthritis	174
LRRK2 suppresses lysosome degradative activity in macrophages and microglia through MiT-TFE transcription factor inhibition	171
IRF3 inhibits nuclear translocation of NF-κB to prevent viral inflammation	169
Ru-P pair sites boost charge transport in hematite photoanodes for exceeding 1% efficient solar water splitting	169
Convergent evolution of venom gland transcriptomes across Metazoa	168
Rab3 mediates a pathway for endocytic sorting and plasma membrane recycling of ordered microdomains	167
A Cdk5-derived peptide inhibits Cdk5/p25 activity and improves neurodegenerative phenotypes	167
Inhibitors of PARP: Number crunching and structure gazing	166
Structural basis of higher order oligomerization of KSHV inhibitor of cGAS	165
Programmable heterogeneous lamellar lattice architecture for dual mechanical protection	164
NOTUM-mediated WNT silencing drives extravillous trophoblast cell lineage development	163
Interacting pest control and pollination services in coffee systems	162
Genome-wide detection of human variants that disrupt intronic branchpoints	161
Symmetry and asymmetry in biological structures	160
Social stressors associated with age-related T lymphocyte percentages in older US adults: Evidence from the US Health and Retirement Study	159
Cell–matrix feedback controls stretch-induced cellular memory and fibroblast activation	158
Functional alterations in cortical processing of speech in glioma-infiltrated cortex	155
Hatching is modulated by microRNA-378a-3p derived from extracellular vesicles secreted by blastocysts	155
Single-neuron bursts encode pathological oscillations in subcortical nuclei of patients with Parkinson’s disease and essential tremor	155

Repeated occurrences of marine anoxia under high atmospheric O ₂ and icehouse conditions	155
Promoting C–F bond activation via proton donor for CF ₄ decomposition	154
RNA m ⁶ A demethylase ALKBH5 regulates the development of γδ T cells	153
Identification of cap-dependent endonuclease inhibitors with broad-spectrum activity against bunyaviruses	153
Restoring neuronal iron homeostasis revitalizes neurogenesis after spinal cord injury	153
Two-pore channels regulate endomembrane tension to enable remodeling and resolution of phagolysosomes	152
Past insecticide exposure reduces bee reproduction and population growth rate	152
Microfluidics guided by deep learning for cancer immunotherapy screening	152
A degradable form of polyoma small T antigen reveals the high specificity of TAZ in regulating gene expression	151
Revealing the structure of snowflakes using acoustic levitation	150
Rapid shear zone weakening during subduction initiation	149
Insurance and climate risks: Policy lessons from three bounding scenarios	147
Self-consistent dispersal puts tight constraints on the spatiotemporal organization of species-rich metacommunities	146
Malaria parasite evades mosquito immunity by glutaminyl cyclase–mediated posttranslational protein modification	145
Detecting chirality-induced spin selectivity in chromophore-linked DNA hairpins using photogenerated radical pairs	142
Gluing blood into gel by electrostatic interaction using a water-soluble polymer as an embolic agent	142
HLA-B*15:01-positive severe COVID-19 patients lack CD8 ⁺ T cell pools with highly expanded public clonotypes	141
Neuronal mechanism of a BK channelopathy in absence epilepsy and dyskinesia	141
Exploiting breakdown in nonhost effector–target interactions to boost host disease resistance	140
Correlated substitutions reveal SARS-like coronaviruses recombine frequently with a diverse set of structured gene pools	139
Heterogenous biofilm mass-transport model replicates periphery sequestration of antibiotics in Pseudomonas aeruginosa PAO1 microcolonies	139
An HLA-E-targeted TCR bispecific molecule redirects T cell immunity against Mycobacterium tuberculosis	138
Identification of potent pan-ephrin receptor kinase inhibitors using DNA-encoded chemistry technology	138
Polymorphic transposable elements contribute to variation in recombination landscapes	138
Cytoplasmic stirring by active carpets	138
The 2025 M _w 7.7 Mandalay, Myanmar, earthquake reveals a complex earthquake cycle with clustering and variable segmentation on the Sagaing Fault	137
Mitochondria regulate MR1 protein expression and produce self-metabolites that activate MR1-restricted T cells	135
CoRa—A general approach for quantifying biological feedback control	134
A gain-of-function HCN4 mutant in the HCN domain is responsible for inappropriate sinus tachycardia in a Spanish family	134
Neuronal sensorimotor integration guiding salt concentration navigation in Caenorhabditis elegans	133
Regulation of Na/Ca exchange by cytoplasmic protons modifies intracellular calcium dynamics and the cardiac response to ischemia	133
ARRDC4-mediated glycolysis enhances innate immunity to influenza A virus through fructose-1,6-bisphosphate	133
Mafba and Mafbb regulate microglial colonization of zebrafish brain via controlling chemotaxis receptor expression	132
Ancient Maya reservoirs, constructed wetlands, and future water needs	132
Deep structure–function analysis of the endonuclease Mus81 with dominant mutational scanning	131
Inversion of pop-out for a distracting feature dimension in monkey visual cortex	131
Global monitoring of the impact of the COVID-19 pandemic through online surveys sampled from the Facebook user base	131
Water striders are impervious to raindrop collision forces and submerged by collapsing craters	131
Adaptive cooling strategy via human hair: High optothermal conversion efficiency of solar radiation into thermal dissipation	131
Hydrodynamic flow and concentration gradients in the gut enhance neutral bacterial diversity	130
Long-term employment and health effects of active labor market programs	130
Synchronous spiking of cerebellar Purkinje cells during control of movements	130
The importance of geography in forecasting future fire patterns under climate change	130
A law of data separation in deep learning	130
Electrophysiological measures from human iPSC-derived neurons are associated with schizophrenia clinical status and predict individual cognitive performance	129
Hidden complexity of α7 nicotinic acetylcholine receptor desensitization revealed by MD simulations and Markov state modeling	129
Emotional (in)stability: Neuroticism is associated with increased variability in negative emotion after all	128
State-dependent motion of a genetically encoded fluorescent biosensor	128
Strategy to develop broadly effective multivalent COVID-19 vaccines against emerging variants based on Ad5/35 platform	128
Atmospheric variability contributes to increasing wildfire weather but not as much as global warming	126
Identification of two archaeal GDGT lipid–modifying proteins reveals diverse microbes capable of GMGT biosynthesis and modification	126
Blockage of MLKL prevents myelin damage in experimental diabetic neuropathy	126
Single hormone or synthetic agonist induces G_s/G_icoupling selectivity of EP receptors via distinct binding modes and propagating paths	125
Distinct neural networks derived from galanin-containing nociceptors and neurotensin-expressing pruriceptors	124
Diverse roles of pontine NPS-expressing neurons in sleep regulation	123
Symmetric activation and modulation of the human calcium-sensing receptor	123
A TLR4/TRAF6-dependent signaling pathway mediates NCoR coactivator complex formation for inflammatory gene activation	123
Glucuronic acid confers colonization advantage to enteric pathogens	123
Early life lead exposure from private well water increases juvenile delinquency risk among US teens	122
An IL-23-STAT4 pathway is required for the proinflammatory function of classical dendritic cells during CNS inflammation	121
Modes of Pangean lake level cyclicity driven by astronomical climate pacing modulated by continental position and p CO2	121
Emergent time scales of epistasis in protein evolution	120
Epigenetic silencing of selected hypothalamic neuropeptides in narcolepsy with cataplexy	119
Dual-rail encoding with superconducting cavities	119
Cell cycle plasticity underlies fractional resistance to palbociclib in ER+/HER2− breast tumor cells	119
Maple samaras recover autorotation following raindrop collisions	118
Engineered CaM2 modulates nuclear calcium oscillation and enhances legume root nodule symbiosis	118
Reduced physiological plasticity in a fish adapted to stable temperatures	118
Gap junction–transported cAMP from the niche controls stem cell progeny differentiation	118
Serum apolipoprotein A-I depletion is causative to silica nanoparticles–induced cardiovascular damage	117
Parameters of clustered suboptimal miRNA biogenesis	116
Accurate identification and mechanistic evaluation of pathogenic missense variants with Rhapsody-2	116
Protein dynamics underlies strong temperature dependence of heat receptors	115
Photomolecular effect: Visible light interaction with air–water interface	115
Sm complex assembly and 5′ cap trimethylation promote selective processing of snRNAs by the 3′ exonuclease TOE1	115
The case and context for atmospheric methane as an exoplanet biosignature	115
Direct measuring of single–heterogeneous bubble nucleation mediated by surface topology	114
Quantitative comparison of nuclear transport inhibition by SARS coronavirus ORF6 reveals the importance of oligomerization	113
Correction for Wang et al., Interplay of mevalonate and Hippo pathways regulates RHAMM transcription via YAP to modulate breast cancer cell motility	112
A heritable iron memory enables decision-making in Escherichia coli	112

Independent transitions to fully planktonic life cycles shaped the global distribution of medusozoans in the epipelagic zone	112
Dynamical differential covariance recovers directional network structure in multiscale neural systems	112
Directional water navigation and reallocation in Tillandsia capitata	112
Bacterial lifestyle shapes pangenomes	112
Gain of function due to increased opening probability by two KCNQ5 pore variants causing developmental and epileptic encephalopathy	111
Depressive symptoms during the transition to adolescence: Left hippocampal volume as a marker of social context sensitivity	111
SARS-CoV-2-derived RNA replicons as safe and effective vaccines	111
Cas9-mediated gene-editing frequency in microalgae is doubled by harnessing the interaction between importin α and phytopathogenic NLSs	111
Kinetic pathways of solid–solid phase transitions dictated by short-range interactions	110
Bottlenose dolphin mothers modify signature whistles in the presence of their own calves	110
Greener skies? The quest for sustainable flying	110
Identification of KU-55933 as an anti-atherosclerosis compound by using a hemodynamic-based high-throughput drug screening platform	109
Atomic resolution structure of full-length human insulin fibrils	109
Memory’s gatekeeper: The role of PFC in the encoding of congruent events	108
Croquemort elicits activation of the immune deficiency pathway in ticks	108
Functional redundancy in the toxic pathway of Bt protein Cry1Ab, but not Cry1Fa, against the Asian corn borer	107
Empowering genome-wide association studies via a visualizable test based on the regional association score	107
Roughness-dependent scaling of the contact area and separation gap with pressure for glassy polymers	106
Retraction for Li et al., Synthetic lethality of combined glutaminase and Hsp90 inhibition in mTORC1-driven tumor cells	106
Stomatal patchiness and cellular computing	106
Mercury’s complex legacy	105
Endurance athletes hiding in plain sight in the high Andes	105
Individuals benefit individual out-group members rather than harm in-group members	105
Circadian clock control of interactions between eIF2α kinase CPC-3 and GCN1 with ribosomes regulates rhythmic translation initiation	105
Modeling DNA methyltransferase function to predict epigenetic correlation patterns in healthy and cancer cells	105
The origin of color categories	104
Correction for Magesh et al., Co-zorbs: Motile, multispecies biofilms aid transport of diverse bacterial species	104
Temperature-dependent fold-switching mechanism of the circadian clock protein KaiB	104
Correction to Supporting Information for Ikeda et al., Seesaw protein: Design of a protein that adopts interconvertible alternative functional conformations and its dynamics	103
Aberrant neuronal hyperactivation causes an age-dependent behavioral decline in Caenorhabditis elegans	103
Untangling the CD4 T cell response to the microbiota	102
Investigating 3D microbial community dynamics of the rhizosphere using quantitative phase and fluorescence microscopy	102
Ciliary localization of a light-activated neuronal GPCR shapes behavior	102
Impression management in research reporting: When effects are not really as pronounced as claimed	101
Late Cretaceous community structure changed before the asteroid	101
Thermodynamic consistency of autocatalytic cycles	100
Modeling blood metabolite homeostatic levels reduces sample heterogeneity across cohorts	100
Correction for Garaizar et al., Toward understanding lipid reorganization in RNA lipid nanoparticles in acidic environments	100
Photoreduction of mercuric bromides in polar ice	100
Correction to Supporting Information for Bardy et al., Neuronal medium that supports basic synaptic functions and activity of human neurons in vitro	100
Identification of AK4 and RHOC as potential oncogenes addicted by adult T cell leukemia	99
Clocking out and letting go to unleash green biotech applications in a photosynthetic host	99
Adaptive DNA amplification of synthetic gene circuit opens a way to overcome cancer chemoresistance	99
Methodological and conceptual considerations of the TCM evolution	99
Indigenous Knowledge as a sole data source in habitat selection functions	99
Resilience of deep aquifer microbial communities to seasonal hydrological fluctuations	99
Breaking the symmetry of cell contractility drives tubulogenesis via CXCL1 polarization	98
Graphene nanoripples enable unexpected catalytic reactivity	98
How defective mitochondrial electrical activity leads to inherited blindness	98
Trojan horse peptide conjugates remodel the activity spectrum of clinical antibiotics	98
DNA hypomethylation ameliorates erosive inflammatory arthritis by modulating interferon regulatory factor-8	97
Genetic ablation of the TET family in retinal progenitor cells impairs photoreceptor development and leads to blindness	97
Thermo-photo catalytic anode process for carbonate-superstructured solid fuel cells	97
Fluorescence detection of dopamine signaling to the primate striatum in relation to stimulus–reward associations	97
In This Issue	97
Accounting for spatial sampling patterns in Bayesian phylogeography	97
Pinning down a perpetrator in postsurgical eye pain	97
Prolonged exertion of self-control causes increased sleep-like frontal brain activity and changes in aggressivity and punishment	97
Correction for Ahituv et al., Starch-rich plant foods 780,000 y ago: Evidence from Acheulian percussive stone tools	96
BRD9 functions as an HIV-1 latency regulatory factor	96
AlphaFold2-based prediction of the co-condensation propensity of proteins	96
A randomized trial of behavioral interventions yielding sustained reductions in distracted driving	96
β-catenin turnover is regulated by Nek10-mediated tyrosine phosphorylation in A549 lung adenocarcinoma cells	95
Using neuroimaging genomics to investigate the evolution of human brain structure	95
Vulnerability to natural disasters and sustainable consumption: Unraveling political and regional differences	95
Touching the classical scaling in penetrative convection	95
Identifying regulation with adversarial surrogates	95
Hidden in plain sight: (Re)definition of a key lepidopteran color patterning gene	95
The Titanic question in TB control: Should we worry about the bummock?	94
Protein kinase Cγ in cerebellar Purkinje cells regulates Ca ²⁺ -activated large-conductance K ⁺ channels and motor coordination	94
IL-1 receptor antagonism reveals a yin-yang relationship between NFκB and interferon signaling in chronic lymphocytic leukemia	94
Phylogenomics of the tetraploid Hawaiian lobeliads: Implications for their origin, dispersal history, and adaptive radiation	94
Persistent deep water anoxia in the eastern South Atlantic during the last ice age	94
Thermoelectricity, metallic liquidity, and magnetohydrodynamics	94
Ultrafast transient absorption spectra and kinetics of human blue cone visual pigment at room temperature	93
Tsg101 mimicry of canonical E2 enzymes underlies its role in ubiquitin signaling	93
Propulsive cell entry diverts pathogens from immune degradation by remodeling the phagocytic synapse	92
The James Webb Space Telescope prompts a rethink of how galaxies form	92
Modeling the population-level impact of a third dose of MMR vaccine on a mumps outbreak at the University of Iowa	92
Revealing land control dynamics in emerging agricultural frontiers	91
High UV damage and low repair, but not cytosine deamination, stimulate mutation hotspots at ETS binding sites in melanoma	91
The decade-long growth of government-authored news media in China under Xi Jinping	91
Part of the gender gap in voting for Democrats arises because a higher proportion of women than men voters are Black	91
Consistently estimating network statistics using aggregated relational data	91
Balance and imbalance in biogeochemical cycles reflect the operation of closed, exchange, and open sets	91
Observing heroic behavior and its influencing factors in immersive virtual environments	91
Dynamic early recruitment of GAK–Hsc70 regulates coated pit maturation	91
The structural origin of the efficient photochromism in natural minerals	90
Band gap opening of metallic single-walled carbon nanotubes via noncovalent symmetry breaking	90
Reply to Apanovich and Weeks: Exceptions exist, as recognized in the paper, but are too rare to challenge the original findings	90
The retrotransposon R2 maintains Drosophila ribosomal DNA repeats	90
Reversal of an existing hearing loss by gene activation in Spns2 mutant mice	90
MBD2a–NuRD binds to the methylated γ-globin gene promoter and uniquely forms a complex required for silencing of HbF expression	90
Simple, fast, and flexible framework for matrix completion with infinite width neural networks	89
Correction to Supporting Information for Ahuja et al., Bach1 derepression is neuroprotective in a mouse model of Parkinson’s disease	89