OOIR: Observatory of International Research

Papers

(The TQCC of Molecular Pharmacology is 6. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-01-01 to 2026-01-01.)

Article	Citations
A 19F-qNMR-Guided Mathematical Model for G Protein-Coupled Receptor Signaling	65
Fat traffic control: S-acylation in axonal transport	38
Simplified Method for Kinetic and Thermodynamic Screening of Cardiotonic Steroids through the K+-Dependent Phosphatase Activity of Na+/K+-ATPase with Chromogenic pNPP Substrate	37
In Vitro Pharmacological Profile of KW-6356, a Novel Adenosine A2A Receptor Antagonist/Inverse Agonist	34
Structural Basis for the Allosteric Inhibition of Hypoxia-Inducible Factor 2 by Belzutifan	32
Enhancing remyelination in multiple sclerosis via M1 muscarinic acetylcholine receptor	29
Editorial Board	28
Editorial Board	25
Table of Contents	25
Regulation of organic anion transporting polypeptide 1B1 transport function by concurrent phosphorylation and lysine-acetylation: A novel posttranslational regulation mechanism	24
Lysine Demethylase 6B Regulates Prostate Cancer Cell Proliferation by Controlling c-MYC Expression	24
Isoprenaline shows unique kinase dependencies in stimulating β1AR–β-arrestin2 interaction compared to endogenous catecholamines	24
Thermogenic Modulation of Adipose Depots: A Perspective on Possible Therapeutic Intervention with Early Cardiorenal Complications of Metabolic Impairment	23
Mechanism-Based Inactivation of Human Aldehyde Oxidase by Erlotinib: Mechanistic Insights from Structural Analogues and Molecular Docking	22
Development of a Novel Assay for Direct Assessment of Selective Amylin Receptor Activation Reveals Novel Differences in Behavior of Selective and Nonselective Peptide Agonists	22
Chrysosplenol-C Increases Contraction by Augmentation of Sarcoplasmic Reticulum Ca2+ Loading and Release via Protein Kinase C in Rat Ventricular Myocytes	20
Pore Opening, Not Voltage Sensor Movement, Underpins the Voltage-Dependence of Facilitation by a hERG Blocker	20
Resveratrol Binds Nuclear Receptor 4A1 (NR4A1) and Acts as an NR4A1 Antagonist in Lung Cancer Cells	18
St. John’s Wort Formulations Induce Rat CYP3A23-3A1 Independent of Their Hyperforin Content	17
Editorial Board	16
Corrigendum to “Antitumor Effects of Dehydroxymethylepoxyquinomicin, a Novel Nuclear Factor-κB Inhibitor, in Human Liver Cancer Cells Are Mediated through a Reactive Oxygen Species-Dependent Mechanism	16
Table of Contents	16
Cholesterol residence time drives regulation of the G protein-coupled cholecystokinin receptor	15
Research approaches for exploring the hidden conversations of G protein-coupled receptor transactivation	15
The Emerging Structural Pharmacology of ATP-Sensitive Potassium Channels	15

6,7-Dichloro-1H-indole-2,3-dione-3-oxime functions as a superagonist for the intermediate-conductance Ca2+-activated K+ channel KCa3.1	15
Targeting Cyclophilin A and CD147 to Inhibit Replication of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) and SARS-CoV-2–Induced Inflammation	14
Discovery of RGS2-FBXO44 interaction inhibitors using a cell-based NanoBit assay	14
Mechanisms to Repair Stalled Topoisomerase II-DNA Covalent Complexes	14
GPR83 Engages Endogenous Peptides from Two Distinct Precursors to Elicit Differential Signaling	13
Englerin A Inhibits T-Type Voltage-Gated Calcium Channels at Low Micromolar Concentrations	13
Structural Basis of the Negative Allosteric Modulation of 5-BDBD at Human P2X4 Receptors	13
Editorial Board	12
Editorial Board	12
Table of Contents	11
Cholesterol Inhibition of Slo1 Channels Is Calcium-Dependent and Can Be Mediated by Either High-Affinity Calcium-Sensing Site in the Slo1 Cytosolic Tail	11
Emerging roles of ubiquitin-specific proteases in the cardiovascular system	11
Table of Contents	11
BAY58-2667 Activates Different Soluble Guanylyl Cyclase Species by Distinct Mechanisms that Indicate Its Principal Target in Cells is the Heme-Free Soluble Guanylyl Cyclase-Heat Shock Protein 90 Compl	11
Corticosterone stimulates synthesis of 2-arachidonoylglycerol via putative membrane-bound glucocorticoid receptors and inhibits GABA release via CB1 cannabinoid receptors in the ventrolateral periaque	11
Role of HNF4A-AS1/HNRNPC-mediated HNF4A ubiquitination protection against ritonavir-induced hepatotoxicity	11
Modulation of Kv7 Channel Currents by Echinocystic Acid	11
A brief history of nerve action potentials after 1600	11
The Sulfated Steroids Pregnenolone Sulfate and Dehydroepiandrosterone Sulfate Inhibit the α1β3γ2L GABAA Receptor by Stabilizing a Novel Nonconducting State	11
Differential RELA and GR recruitment to the BIRC3/BIRC2 locus: Molecular insight as to combinatorial regulation by proinflammatory cytokines and glucocorticoid	11
Contents	10
Corrigendum to “Novel Thiosemicarbazones Inhibit Lysine-Rich Carcinoembryonic Antigen-Related Cell Adhesion Molecule 1 (CEACAM1) Coisolated (LYRIC) and the LYRIC-Induced Epithelial- Mesenchymal Transi	10
Distinctive patterns of G protein coupling induced by the structurally similar 5-HT2A receptor ligands ketanserin and altanserin in human prefrontal cortex	10
The β2 adrenergic receptor cross-linked interactome identifies 14-3-3 proteins as regulating the availability of signaling-competent receptors	10
Commentary on the fourth Transatlantic G Protein-Coupled Receptor Symposium for early-career investigators	10
Editorial Board	10
G-Protein Coupled Receptor Signaling and Mammalian Target of Rapamycin Complex 1 Regulation	10
Repurposing lapatinib as a triple antagonist of chemokine receptors 3, 4, and 5	10
Rational design of biased G protein-coupled receptor agonists	10
Gα Protein Signaling Bias at Serotonin 1A Receptor	10
Expression of concern: “Caveolin-1 and Lipid Microdomains Regulate Gs Trafficking and Attenuate Gs/Adenylyl Cyclase Signaling” [Molecular Pharmacology, Volume 76, Issue 5, November 2009, Pages 1082-10	10
Editorial Board	10
EP4 Receptor Conformation Sensor Suited for Ligand Screening and Imaging of Extracellular Prostaglandins	10
Correction to “Sulforaphane Suppresses Polycomb Group Protein Level via a Proteasome-Dependent Mechanism in Skin Cancer Cells”	10
Correction to “A Brief Overview of the Toxic Sphingomyelinase Ds of Brown Recluse Spider Venom and Other Organisms and Simple Methods To Detect Production of Its Signature Cyclic Ceramide Phosphate”	10
Discovery and In Vitro Characterization of BAY 2686013, an Allosteric Small Molecule Antagonist of the Human Pituitary Adenylate Cyclase-Activating Polypeptide Receptor	10
Predicting compounds that interact with the 2 known agonist-induced conformations of the human β1-adrenoceptor	9
Editorial Board	9
A Novel Role of Uricosuric Agent Benzbromarone in BK Channel Activation and Reduction of Airway Smooth Muscle Contraction	9
Table of Contents	9
Heterogeneous nuclear ribonucleoprotein A/B drives gastric cancer and epithelial-mesenchymal transition via the Akt-GSK3β-Wnt pathway	9
β-Caryophyllene Inhibits Monoacylglycerol Lipase Activity and Increases 2-Arachidonoyl Glycerol Levels In Vivo: A New Mechanism of Endocannabinoid-Mediated Analgesia?	9
Going Rogue: Mechanisms, Regulation, and Roles of Mutationally Activated Gα in Human Cancer	9
Corrigendum to “Targeting the Metastasis Suppressor, N-Myc Downstream Regulated Gene-1, with Novel Di-2- Pyridylketone Thiosemicarbazones: Suppression of Tumor Cell Migration and Cell-Collagen Adhesio	9
The effects of hippocampal miR-34c-5p on the age-related discrepancies in susceptibility to traumatic stress in the post-traumatic stress disorder mice model	9
Editorial Board	9
Table of Contents	9
Corrigendum to “The Natural Compound Withaferin A Covalently Binds to Cys239 of β-Tubulin to Promote Tubulin Degradation”	9
GRK2 and GRK5 – the two critical kinases in cardiac pathophysiology	8
Roles of Receptor Phosphorylation and Rab Proteins in G Protein-Coupled Receptor Function and Trafficking	8

The M3 Muscarinic Acetylcholine Receptor Can Signal through Multiple G Protein Families	8
The Glycosylated N-Terminal Domain of MUC1 Is Involved in Chemoresistance by Modulating Drug Permeation Across the Plasma Membrane	8
Allosteric Modulator KM822 Attenuates Behavioral Actions of Amphetamine in Caenorhabditis elegans through Interactions with the Dopamine Transporter DAT-1	8
Development of an LC-MS/MS Method to Measure Sphingolipids in CSF from Patients with Multiple Sclerosis	8
Induced Fit Describes Ligand Binding to Membrane-Associated Cytochrome P450 3A4	8
Upregulating vascular endothelial KCa2.3 channels alleviates pulmonary hypertension in mice	7
Editorial Board	7
N-(4-Bromo-2,5-Dimethoxyphenethyl)-6-(4-Phenylbutoxy)Hexan-1-Amine (XOB): A Novel Phenylalkylamine Antagonist of Serotonin 2A Receptors and Voltage-Gated Sodium Channels	7
Pharmacological Targeting of Senescence with Senolytics as a New Therapeutic Strategy for Neurodegeneration	7
Circumvention of Topoisomerase IIα Intron 19 Intronic Polyadenylation in Acquired Etoposide-Resistant Human Leukemia K562 Cells	7
Activation of TRPV3 channels in bladder cancer cells stimulates ATP release	7
Insights Into the Differential Desensitization of α4β2 Nicotinic Acetylcholine Receptor Isoforms Obtained With Positive Allosteric Modulation of Mutant Receptors	7
Live Tissue Imaging Reveals Distinct Transcellular Pathways for Organic Cations and Anions at the Blood-Cerebrospinal Fluid Barrier	7
CCT and CCT-Like Modular Protein Interaction Domains in WNK Signaling	7
Editorial Board	6
Drugs Form Ternary Complexes with Human Liver Fatty Acid Binding Protein 1 (FABP1) and FABP1 Binding Alters Drug Metabolism	6
Aryl Hydrocarbon Receptor as a Therapeutical Target of Environmentally Induced Skin Conditions	6
Electrophysiological characterization of the state-dependent inhibition of Kv7.1 and IKs by UCL2077	6
Molecular determinants of 2-aminoethoxydiphenyl borate sensitivity of transient receptor potential vanilloid 2-unexpected differences between 2 rodent orthologs	6
Mechanisms of Action Underlying Conductance-Modifying Positive Allosteric Modulators of the NMDA Receptor	6
Fluorizoline Blocks the Interaction between Prohibitin-2 and γ-Glutamylcyclotransferase and Induces p21 Expression in MCF7 Breast Cancer Cells	6
Inhibition of Cardiac Kv4.3/KChIP2 Channels by Sulfonylurea Drug Gliquidone	6
Pharmacological Characterization and Radiolabeling of VUF15485, a High-Affinity Small-Molecule Agonist for the Atypical Chemokine Receptor ACKR3	6
Elucidating Molecular Mechanisms Governing TNF-Alpha-Mediated Regulation of Amyloid Beta 42 Uptake in Blood-Brain Barrier Endothelial Cells	6
Fanning the Flames of Endoplasmic Reticulum (ER) Stress: Can Sphingolipid Metabolism Be Targeted to Enhance ER Stress–Associated Immunogenic Cell Death in Cancer?	6
The thiazolidinedione drug troglitazone inhibits Gq signaling through direct binding to the Gq alpha subunit through inhibition of GDP release	6