OOIR: Observatory of International Research

Papers

(The TQCC of Molecular Pharmacology is 6. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-08-01 to 2026-08-01.)

Article	Citations
Expression of concern: “Adelmidrol, a Palmitoylethanolamide Analogue, as a New PharmacologicalTreatment for the Management of Inflammatory Bowel Disease” [Mol. Pharmacol. 2016; 90: 549-561] by Cordaro	53
UCM-A86 is a selective positive allosteric modulator of GluN1/GluN3 NMDA receptors	45
A 19F-qNMR-Guided Mathematical Model for G Protein-Coupled Receptor Signaling	41
In Vitro Pharmacological Profile of KW-6356, a Novel Adenosine A2A Receptor Antagonist/Inverse Agonist	41
Enhancing remyelination in multiple sclerosis via M1 muscarinic acetylcholine receptor	40
Fat traffic control: S-acylation in axonal transport	39
Simplified Method for Kinetic and Thermodynamic Screening of Cardiotonic Steroids through the K+-Dependent Phosphatase Activity of Na+/K+-ATPase with Chromogenic pNPP Substrate	32
Structural Basis for the Allosteric Inhibition of Hypoxia-Inducible Factor 2 by Belzutifan	28
Editorial Board	23
Editorial Board	19
Isoprenaline shows unique kinase dependencies in stimulating β1AR–β-arrestin2 interaction compared to endogenous catecholamines	19
Development of a Novel Assay for Direct Assessment of Selective Amylin Receptor Activation Reveals Novel Differences in Behavior of Selective and Nonselective Peptide Agonists	18
Mechanism-based inactivation of human aldehyde oxidase by erlotinib: Mechanistic insights from structural analogs and molecular docking	17
Regulation of organic anion transporting polypeptide 1B1 transport function by concurrent phosphorylation and lysine-acetylation: A novel posttranslational regulation mechanism	17
Binding affinities for histamine receptors 1 to 4: Systematic comparison of ligands from the Psychoactive Drug Screening Program Ki database and International Union of Basic and Clinical Pharmacology/	16
Molecular pharmacology of mGlu7/8 heterodimers reveals unique properties of orthosteric agonists and positive allosteric modulators	16
Identification of potent and selective small molecule TALK-1 inhibitors that promote β-cell function	16
Cholesterol residence time drives regulation of the G protein-coupled cholecystokinin receptor	15
Local protein kinase A signaling pathologies in the endocrine system	15
Thermogenic Modulation of Adipose Depots: A Perspective on Possible Therapeutic Intervention with Early Cardiorenal Complications of Metabolic Impairment	15
Resveratrol Binds Nuclear Receptor 4A1 (NR4A1) and Acts as an NR4A1 Antagonist in Lung Cancer Cells	14
The Emerging Structural Pharmacology of ATP-Sensitive Potassium Channels	14
Targeting Cyclophilin A and CD147 to Inhibit Replication of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) and SARS-CoV-2–Induced Inflammation	14
Discovery of RGS2-FBXO44 interaction inhibitors using a cell-based NanoBit assay	14
St. John’s Wort Formulations Induce Rat CYP3A23-3A1 Independent of Their Hyperforin Content	13

Research approaches for exploring the hidden conversations of G protein-coupled receptor transactivation	13
6,7-Dichloro-1H-indole-2,3-dione-3-oxime functions as a superagonist for the intermediate-conductance Ca2+-activated K+ channel KCa3.1	13
Corrigendum to “Antitumor Effects of Dehydroxymethylepoxyquinomicin, a Novel Nuclear Factor-κB Inhibitor, in Human Liver Cancer Cells Are Mediated through a Reactive Oxygen Species-Dependent Mechanism	13
Pore Opening, Not Voltage Sensor Movement, Underpins the Voltage-Dependence of Facilitation by a hERG Blocker	13
BAY58-2667 Activates Different Soluble Guanylyl Cyclase Species by Distinct Mechanisms that Indicate Its Principal Target in Cells is the Heme-Free Soluble Guanylyl Cyclase-Heat Shock Protein 90 Compl	12
Englerin A Inhibits T-Type Voltage-Gated Calcium Channels at Low Micromolar Concentrations	12
Emerging roles of ubiquitin-specific proteases in the cardiovascular system	12
Role of HNF4A-AS1/HNRNPC-mediated HNF4A ubiquitination protection against ritonavir-induced hepatotoxicity	12
Differential RELA and GR recruitment to the BIRC3/BIRC2 locus: Molecular insight as to combinatorial regulation by proinflammatory cytokines and glucocorticoid	12
ROLES OF THE PHOSPHORYLATION SITES OF DISTINCT α1A-ADRENERGIC RECEPTOR DOMAINS	12
Table of Contents	12
Editorial Board	12
A brief history of nerve action potentials after 1600	12
Corticosterone stimulates synthesis of 2-arachidonoylglycerol via putative membrane-bound glucocorticoid receptors and inhibits GABA release via CB1 cannabinoid receptors in the ventrolateral periaque	12
Correction to “A Brief Overview of the Toxic Sphingomyelinase Ds of Brown Recluse Spider Venom and Other Organisms and Simple Methods To Detect Production of Its Signature Cyclic Ceramide Phosphate”	11
Table of Contents	11
Corrigendum to “A subunit-selective negative allosteric modulator of GluN1/GluN3A glycine-activated receptor” [Molecular Pharmacology 108 (2026) 100104]	11
Discovery and In Vitro Characterization of BAY 2686013, an Allosteric Small Molecule Antagonist of the Human Pituitary Adenylate Cyclase-Activating Polypeptide Receptor	11
Modulation of Kv7 Channel Currents by Echinocystic Acid	11
Commentary on the fourth Transatlantic G Protein-Coupled Receptor Symposium for early-career investigators	11
Distinctive patterns of G protein coupling induced by the structurally similar 5-HT2A receptor ligands ketanserin and altanserin in human prefrontal cortex	11
Gα Protein Signaling Bias at Serotonin 1A Receptor	11
Rational design of biased G protein-coupled receptor agonists	11
Correction to “Sulforaphane Suppresses Polycomb Group Protein Level via a Proteasome-Dependent Mechanism in Skin Cancer Cells”	11
EP4 Receptor Conformation Sensor Suited for Ligand Screening and Imaging of Extracellular Prostaglandins	11
The β2 adrenergic receptor cross-linked interactome identifies 14-3-3 proteins as regulating the availability of signaling-competent receptors	10
Editorial Board	10
Repurposing lapatinib as a triple antagonist of chemokine receptors 3, 4, and 5	10
Contents	10
Editorial Board	9
Corrigendum to “Novel Thiosemicarbazones Inhibit Lysine-Rich Carcinoembryonic Antigen-Related Cell Adhesion Molecule 1 (CEACAM1) Coisolated (LYRIC) and the LYRIC-Induced Epithelial- Mesenchymal Transi	9
Expression of concern: “Caveolin-1 and Lipid Microdomains Regulate Gs Trafficking and Attenuate Gs/Adenylyl Cyclase Signaling” [Molecular Pharmacology, Volume 76, Issue 5, November 2009, Pages 1082-10	9
The effects of hippocampal miR-34c-5p on the age-related discrepancies in susceptibility to traumatic stress in the post-traumatic stress disorder mice model	9
Editorial Board	8
Going Rogue: Mechanisms, Regulation, and Roles of Mutationally Activated Gα in Human Cancer	8
Table of Contents	8
β-Caryophyllene Inhibits Monoacylglycerol Lipase Activity and Increases 2-Arachidonoyl Glycerol Levels In Vivo: A New Mechanism of Endocannabinoid-Mediated Analgesia?	8
Predicting compounds that interact with the 2 known agonist-induced conformations of the human β1-adrenoceptor	8
Editorial Board	8
Structural and molecular determinants of glutamate transporter allosteric modulators	8
Heterogeneous nuclear ribonucleoprotein A/B drives gastric cancer and epithelial-mesenchymal transition via the Akt-GSK3β-Wnt pathway	8
Corrigendum to “The Natural Compound Withaferin A Covalently Binds to Cys239 of β-Tubulin to Promote Tubulin Degradation”	7
The M3 Muscarinic Acetylcholine Receptor Can Signal through Multiple G Protein Families	7
Editorial Board	7
GRK2 and GRK5—The 2 critical kinases in cardiac pathophysiology	7
Induced Fit Describes Ligand Binding to Membrane-Associated Cytochrome P450 3A4	7
Promotion of Tumor Cell Senescence by the Antibody–Drug Conjugate, Sacituzumab Govitecan	7
Table of Contents	7
Corrigendum to “Targeting the Metastasis Suppressor, N-Myc Downstream Regulated Gene-1, with Novel Di-2- Pyridylketone Thiosemicarbazones: Suppression of Tumor Cell Migration and Cell-Collagen Adhesio	7
The Glycosylated N-Terminal Domain of MUC1 Is Involved in Chemoresistance by Modulating Drug Permeation Across the Plasma Membrane	7

A Novel Role of Uricosuric Agent Benzbromarone in BK Channel Activation and Reduction of Airway Smooth Muscle Contraction	7
Development of an LC-MS/MS Method to Measure Sphingolipids in CSF from Patients with Multiple Sclerosis	7
Elucidating the binding and metabolic interactions of sunitinib and sorafenib with Cytochrome P450s CYP2U1 and CYP2D6	6
Elucidating molecular mechanisms governing tumor necrosis factor-alpha–mediated regulation of amyloid beta 42 uptake in blood-brain barrier endothelial cells	6
Loss of α-cell GRK2 modulates glucagon response and supports cardiac function	6
Circumvention of Topoisomerase IIα Intron 19 Intronic Polyadenylation in Acquired Etoposide-Resistant Human Leukemia K562 Cells	6
Fanning the Flames of Endoplasmic Reticulum (ER) Stress: Can Sphingolipid Metabolism Be Targeted to Enhance ER Stress–Associated Immunogenic Cell Death in Cancer?	6
N-(4-Bromo-2,5-Dimethoxyphenethyl)-6-(4-Phenylbutoxy)Hexan-1-Amine (XOB): A Novel Phenylalkylamine Antagonist of Serotonin 2A Receptors and Voltage-Gated Sodium Channels	6
Insights Into the Differential Desensitization of α4β2 Nicotinic Acetylcholine Receptor Isoforms Obtained With Positive Allosteric Modulation of Mutant Receptors	6
Electrophysiological characterization of the state-dependent inhibition of Kv7.1 and IKs by UCL2077	6
Activation of TRPV3 channels in bladder cancer cells stimulates ATP release	6
The thiazolidinedione drug troglitazone inhibits Gq signaling through direct binding to the Gq alpha subunit through inhibition of GDP release	6
Cepharanthine, a valuable sanative alternative for hepatocellular carcinoma through regulating Hippo-Yes-associated protein signal transduction	6
Pharmacological Targeting of Senescence with Senolytics as a New Therapeutic Strategy for Neurodegeneration	6
Upregulating vascular endothelial KCa2.3 channels alleviates pulmonary hypertension in mice	6
Inhibition of Cardiac Kv4.3/KChIP2 Channels by Sulfonylurea Drug Gliquidone	6
Pharmacological Characterization and Radiolabeling of VUF15485, a High-Affinity Small-Molecule Agonist for the Atypical Chemokine Receptor ACKR3	6