Molecular Pharmacology

Article	Citations
Expression of concern: “Adelmidrol, a Palmitoylethanolamide Analogue, as a New PharmacologicalTreatment for the Management of Inflammatory Bowel Disease” [Mol. Pharmacol. 2016; 90: 549-561] by Cordaro	53
UCM-A86 is a selective positive allosteric modulator of GluN1/GluN3 NMDA receptors	45
In Vitro Pharmacological Profile of KW-6356, a Novel Adenosine A2A Receptor Antagonist/Inverse Agonist	41
A 19F-qNMR-Guided Mathematical Model for G Protein-Coupled Receptor Signaling	41
Enhancing remyelination in multiple sclerosis via M1 muscarinic acetylcholine receptor	40
Fat traffic control: S-acylation in axonal transport	39
Simplified Method for Kinetic and Thermodynamic Screening of Cardiotonic Steroids through the K+-Dependent Phosphatase Activity of Na+/K+-ATPase with Chromogenic pNPP Substrate	32
Structural Basis for the Allosteric Inhibition of Hypoxia-Inducible Factor 2 by Belzutifan	28
Editorial Board	23
Isoprenaline shows unique kinase dependencies in stimulating β1AR–β-arrestin2 interaction compared to endogenous catecholamines	19
Editorial Board	19
Development of a Novel Assay for Direct Assessment of Selective Amylin Receptor Activation Reveals Novel Differences in Behavior of Selective and Nonselective Peptide Agonists	18
Regulation of organic anion transporting polypeptide 1B1 transport function by concurrent phosphorylation and lysine-acetylation: A novel posttranslational regulation mechanism	17
Mechanism-based inactivation of human aldehyde oxidase by erlotinib: Mechanistic insights from structural analogs and molecular docking	17
Identification of potent and selective small molecule TALK-1 inhibitors that promote β-cell function	16
Binding affinities for histamine receptors 1 to 4: Systematic comparison of ligands from the Psychoactive Drug Screening Program Ki database and International Union of Basic and Clinical Pharmacology/	16
Molecular pharmacology of mGlu7/8 heterodimers reveals unique properties of orthosteric agonists and positive allosteric modulators	16
Thermogenic Modulation of Adipose Depots: A Perspective on Possible Therapeutic Intervention with Early Cardiorenal Complications of Metabolic Impairment	15
Cholesterol residence time drives regulation of the G protein-coupled cholecystokinin receptor	15
Local protein kinase A signaling pathologies in the endocrine system	15
Targeting Cyclophilin A and CD147 to Inhibit Replication of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) and SARS-CoV-2–Induced Inflammation	14
Discovery of RGS2-FBXO44 interaction inhibitors using a cell-based NanoBit assay	14
Resveratrol Binds Nuclear Receptor 4A1 (NR4A1) and Acts as an NR4A1 Antagonist in Lung Cancer Cells	14
The Emerging Structural Pharmacology of ATP-Sensitive Potassium Channels	14
Pore Opening, Not Voltage Sensor Movement, Underpins the Voltage-Dependence of Facilitation by a hERG Blocker	13

St. John’s Wort Formulations Induce Rat CYP3A23-3A1 Independent of Their Hyperforin Content	13
Research approaches for exploring the hidden conversations of G protein-coupled receptor transactivation	13
6,7-Dichloro-1H-indole-2,3-dione-3-oxime functions as a superagonist for the intermediate-conductance Ca2+-activated K+ channel KCa3.1	13
Corrigendum to “Antitumor Effects of Dehydroxymethylepoxyquinomicin, a Novel Nuclear Factor-κB Inhibitor, in Human Liver Cancer Cells Are Mediated through a Reactive Oxygen Species-Dependent Mechanism	13
Table of Contents	12
Editorial Board	12
A brief history of nerve action potentials after 1600	12
Corticosterone stimulates synthesis of 2-arachidonoylglycerol via putative membrane-bound glucocorticoid receptors and inhibits GABA release via CB1 cannabinoid receptors in the ventrolateral periaque	12
BAY58-2667 Activates Different Soluble Guanylyl Cyclase Species by Distinct Mechanisms that Indicate Its Principal Target in Cells is the Heme-Free Soluble Guanylyl Cyclase-Heat Shock Protein 90 Compl	12
Englerin A Inhibits T-Type Voltage-Gated Calcium Channels at Low Micromolar Concentrations	12
Emerging roles of ubiquitin-specific proteases in the cardiovascular system	12
Role of HNF4A-AS1/HNRNPC-mediated HNF4A ubiquitination protection against ritonavir-induced hepatotoxicity	12
Differential RELA and GR recruitment to the BIRC3/BIRC2 locus: Molecular insight as to combinatorial regulation by proinflammatory cytokines and glucocorticoid	12
ROLES OF THE PHOSPHORYLATION SITES OF DISTINCT α1A-ADRENERGIC RECEPTOR DOMAINS	12
Distinctive patterns of G protein coupling induced by the structurally similar 5-HT2A receptor ligands ketanserin and altanserin in human prefrontal cortex	11
Gα Protein Signaling Bias at Serotonin 1A Receptor	11
Rational design of biased G protein-coupled receptor agonists	11
Correction to “Sulforaphane Suppresses Polycomb Group Protein Level via a Proteasome-Dependent Mechanism in Skin Cancer Cells”	11
EP4 Receptor Conformation Sensor Suited for Ligand Screening and Imaging of Extracellular Prostaglandins	11
Correction to “A Brief Overview of the Toxic Sphingomyelinase Ds of Brown Recluse Spider Venom and Other Organisms and Simple Methods To Detect Production of Its Signature Cyclic Ceramide Phosphate”	11
Table of Contents	11
Corrigendum to “A subunit-selective negative allosteric modulator of GluN1/GluN3A glycine-activated receptor” [Molecular Pharmacology 108 (2026) 100104]	11
Discovery and In Vitro Characterization of BAY 2686013, an Allosteric Small Molecule Antagonist of the Human Pituitary Adenylate Cyclase-Activating Polypeptide Receptor	11
Modulation of Kv7 Channel Currents by Echinocystic Acid	11
Commentary on the fourth Transatlantic G Protein-Coupled Receptor Symposium for early-career investigators	11
Contents	10
The β2 adrenergic receptor cross-linked interactome identifies 14-3-3 proteins as regulating the availability of signaling-competent receptors	10
Editorial Board	10
Repurposing lapatinib as a triple antagonist of chemokine receptors 3, 4, and 5	10
The effects of hippocampal miR-34c-5p on the age-related discrepancies in susceptibility to traumatic stress in the post-traumatic stress disorder mice model	9
Editorial Board	9
Corrigendum to “Novel Thiosemicarbazones Inhibit Lysine-Rich Carcinoembryonic Antigen-Related Cell Adhesion Molecule 1 (CEACAM1) Coisolated (LYRIC) and the LYRIC-Induced Epithelial- Mesenchymal Transi	9
Expression of concern: “Caveolin-1 and Lipid Microdomains Regulate Gs Trafficking and Attenuate Gs/Adenylyl Cyclase Signaling” [Molecular Pharmacology, Volume 76, Issue 5, November 2009, Pages 1082-10	9
Editorial Board	8
Structural and molecular determinants of glutamate transporter allosteric modulators	8
Heterogeneous nuclear ribonucleoprotein A/B drives gastric cancer and epithelial-mesenchymal transition via the Akt-GSK3β-Wnt pathway	8
Editorial Board	8
Going Rogue: Mechanisms, Regulation, and Roles of Mutationally Activated Gα in Human Cancer	8
Table of Contents	8
β-Caryophyllene Inhibits Monoacylglycerol Lipase Activity and Increases 2-Arachidonoyl Glycerol Levels In Vivo: A New Mechanism of Endocannabinoid-Mediated Analgesia?	8
Predicting compounds that interact with the 2 known agonist-induced conformations of the human β1-adrenoceptor	8
Table of Contents	7
Corrigendum to “Targeting the Metastasis Suppressor, N-Myc Downstream Regulated Gene-1, with Novel Di-2- Pyridylketone Thiosemicarbazones: Suppression of Tumor Cell Migration and Cell-Collagen Adhesio	7
The Glycosylated N-Terminal Domain of MUC1 Is Involved in Chemoresistance by Modulating Drug Permeation Across the Plasma Membrane	7
A Novel Role of Uricosuric Agent Benzbromarone in BK Channel Activation and Reduction of Airway Smooth Muscle Contraction	7
Development of an LC-MS/MS Method to Measure Sphingolipids in CSF from Patients with Multiple Sclerosis	7
Corrigendum to “The Natural Compound Withaferin A Covalently Binds to Cys239 of β-Tubulin to Promote Tubulin Degradation”	7
The M3 Muscarinic Acetylcholine Receptor Can Signal through Multiple G Protein Families	7
Editorial Board	7
GRK2 and GRK5—The 2 critical kinases in cardiac pathophysiology	7

Induced Fit Describes Ligand Binding to Membrane-Associated Cytochrome P450 3A4	7
Promotion of Tumor Cell Senescence by the Antibody–Drug Conjugate, Sacituzumab Govitecan	7
Cepharanthine, a valuable sanative alternative for hepatocellular carcinoma through regulating Hippo-Yes-associated protein signal transduction	6
Insights Into the Differential Desensitization of α4β2 Nicotinic Acetylcholine Receptor Isoforms Obtained With Positive Allosteric Modulation of Mutant Receptors	6
Pharmacological Targeting of Senescence with Senolytics as a New Therapeutic Strategy for Neurodegeneration	6
Activation of TRPV3 channels in bladder cancer cells stimulates ATP release	6
Inhibition of Cardiac Kv4.3/KChIP2 Channels by Sulfonylurea Drug Gliquidone	6
Pharmacological Characterization and Radiolabeling of VUF15485, a High-Affinity Small-Molecule Agonist for the Atypical Chemokine Receptor ACKR3	6
Elucidating the binding and metabolic interactions of sunitinib and sorafenib with Cytochrome P450s CYP2U1 and CYP2D6	6
Upregulating vascular endothelial KCa2.3 channels alleviates pulmonary hypertension in mice	6
Elucidating molecular mechanisms governing tumor necrosis factor-alpha–mediated regulation of amyloid beta 42 uptake in blood-brain barrier endothelial cells	6
Circumvention of Topoisomerase IIα Intron 19 Intronic Polyadenylation in Acquired Etoposide-Resistant Human Leukemia K562 Cells	6
Fanning the Flames of Endoplasmic Reticulum (ER) Stress: Can Sphingolipid Metabolism Be Targeted to Enhance ER Stress–Associated Immunogenic Cell Death in Cancer?	6
N-(4-Bromo-2,5-Dimethoxyphenethyl)-6-(4-Phenylbutoxy)Hexan-1-Amine (XOB): A Novel Phenylalkylamine Antagonist of Serotonin 2A Receptors and Voltage-Gated Sodium Channels	6
Loss of α-cell GRK2 modulates glucagon response and supports cardiac function	6
Electrophysiological characterization of the state-dependent inhibition of Kv7.1 and IKs by UCL2077	6
The thiazolidinedione drug troglitazone inhibits Gq signaling through direct binding to the Gq alpha subunit through inhibition of GDP release	6
Mechanisms of Action Underlying Conductance-Modifying Positive Allosteric Modulators of the NMDA Receptor	5
Aryl Hydrocarbon Receptor as a Therapeutical Target of Environmentally Induced Skin Conditions	5
Multiomics Analyses Identify Proline Endopeptidase–Like Protein As a Key Regulator of Protein Trafficking, a Pathway Underlying Alzheimer’s Disease Pathogenesis	5
HDAC6 inhibition ameliorates sensory hypersensitivity and reduces immune cell signatures in the dorsal root ganglia in murine chronic pain models	5
Editorial Board	5
Molecular determinants of 2-aminoethoxydiphenyl borate sensitivity of transient receptor potential vanilloid 2-unexpected differences between 2 rodent orthologs	5
Role of Mitochondrial and Cytosolic Folylpolyglutamate Synthetase in One-Carbon Metabolism and Antitumor Efficacy of Mitochondrial-Targeted Antifolates	5
Drugs Form Ternary Complexes with Human Liver Fatty Acid Binding Protein 1 (FABP1) and FABP1 Binding Alters Drug Metabolism	5
A Sentimental Segue	5
Editorial Board	5
Editorial Board	5
Amyloid-Beta Peptides 40 and 42 Employ Distinct Molecular Pathways for Cell Entry and Intracellular Transit at the Blood–Brain Barrier Endothelium	5
The Common LncRNAs of Neuroinflammation-Related Diseases	5
Table of Contents	5
Expression of Ceramide Synthases in Mice and Their Roles in Regulating Acyl-Chain Sphingolipids: A Framework for Baseline Levels and Future Implications in Aging and Disease	5
The CaMKII D135N mutation blocks kinase activity and reduces GluN2B binding	4
Cannabinoid receptor 2 activating antibodies: A promising therapeutic strategy for macrophage-driven fibro-inflammatory diseases	4
Table of Contents	4
Ca2+/calmodulin-dependent inhibitors of adenylyl cyclase 1 as novel nonopioid analgesics for chronic inflammatory pain	4
A Constitutive EGFR Kinase Dimer to Study Inhibitor Pharmacology	4
Substituted Cysteine Modification and Protection with n-Alkyl-MTS Reagents Quantifies Steric Changes Induced by a Mutation in Anesthetic Binding Sites on GABA Type A Receptors	4
Extrachromosomal Circular DNAs, Amplified Oncogenes, and CRISPR-Cas9 System	4
Multiwalled carbon nanotubes activate the NLRP3 inflammasome-dependent pyroptosis in macrophages	4
Table of Contents	4
Correction to “Neratinib Reverses ATP-Binding Cassette B1-Mediated Chemotherapeutic Drug Resistance In Vitro, In Vivo, and Ex Vivo”	4
State-Dependent Inhibition of Nav1.8 Sodium Channels by VX-150 and VX-548	4
Interaction between W41 of the hepatitis B virus preS1 surface peptide and Y146/F274 of the cellular receptor molecule Na+/taurocholate co-transporting polypeptide is essential for virus entry	4
Upacicalcet Is a Novel Secondary Hyperparathyroidism Drug that Targets the Amino Acid Binding Site of Calcium-Sensing Receptor	4
Screening and Identification of a Novel Anti–Siglec-15 Human Antibody 3F1 and Relevant Antitumor Activity	4
Corrigendum to “Repurposing Treprostinil for Enhancing Hematopoietic Progenitor Cell Transplantation”	4
Dual nuclear receptor 4A1 (NR4A1/NR4A2) ligands inhibit glioblastoma growth and target TWIST1	4
Development of a Selective and High Affinity Radioligand, [3H]VU6013720, for the M4 Muscarinic Receptor	4
Atypical Chemokine Receptor 3 “Senses” CXC Chemokine Receptor 4 Activation Through GPCR Kinase Phosphorylation	4
Voltage sensor interaction site for a selective small molecule Nav1.1 sodium channel potentiator that enhances firing of fast-spiking interneurons	4
Evaluation of allosteric N-methyl-d-aspartate receptor modulation by GluN2A-selective antagonists using pharmacological equilibrium modeling	4
Editorial Board	4
Differential Activity of Orthosteric Agonists and Allosteric Modulators at Metabotropic Glutamate Receptor 7	4
Effects of two structurally diverse positive allosteric modulators on signaling bias at the μ-opioid receptor	4
Corrigendum to “Functional Interaction between Transient Receptor Potential V4 Channel and Neuronal Calcium Sensor 1 and the Effects of Paclitaxel”	3
Transcriptional Regulation, Signaling Pathways, and Subcellular Localization of Corticotropin-Releasing Factor Receptors in the Central Nervous System	3
Passive Immunotherapies Targeting Amyloid-β in Alzheimer’s Disease: A Quantitative Systems Pharmacology Perspective	3
Ketamine and Major Ketamine Metabolites Function as Allosteric Modulators of Opioid Receptors	3
Receptor Determinants for β-Arrestin Functional Specificity at C-X-C Chemokine Receptor 5	3
Molecular and cellular effects of hydroxy-1,4 naphthoquinones used in dermatological and cosmetic applications on human protein tyrosine phosphatase PTP1B in human keratinocytes	3
Role of GPR55 in glutamatergic and dopaminergic signaling: A review of preclinical evidence in neuropsychiatric disorders	3
Rare variant in intracellular loop-2 alters the spatial distribution and transducer coupling selectivity of the ghrelin receptor	3
The peroxisome proliferator–activated receptor α/β/γ agonist NCPC-626 from microbial metabolites alleviates metabolic dysfunction–associated steatohepatitis in mice	3
Chemokine receptors – Exemplifying functional divergence in G protein-coupled receptors	3
AKAP6β – A Conductor in the Orchestra of Pathological Cardiomyocyte Gene Transcription	3
Table of Contents	3
Editorial Board	3
Cyclovirobuxine inhibits ferroptosis to mitigate Alzheimer disease in glutamate-induced SH-SY5Y cell: the role of the liquid-liquid phase separation of FTH1	3
A machine learning–based analysis method for small molecule high content screening of three-dimensional cancer spheroid morphology	3
The Small Molecule Antagonist KCI807 Disrupts Association of the Amino-Terminal Domain of the Androgen Receptor with ELK1 by Modulating the Adjacent DNA Binding Domain	3
G protein-coupled receptor–targeted proteolysis-targeting chimeras in cancer therapeutics	3
New Mechanisms Underlying Oncogenesis in Dbl Family Rho Guanine Nucleotide Exchange Factors	3
Agonists of the Nuclear Receptor PPARγ Can Produce Biased Signaling	3
Rescue of Familial Lecithin:Cholesterol Acyltranferase Deficiency Mutations with an Allosteric Activator	3
Contents	3
Alkannin Attenuates Amyloid β Aggregation and Alzheimer’s Disease Pathology	3
Editorial Board	2
Voltage sensors	2
Corrigendum to “Amantadine derivative Amt-1 enhances antiviral defense against influenza A virus via Nrf2/HO-1 pathway” [Molecular Pharmacology 108 (2026) 100099]	2

Therapeutic Potential for Metabotropic Glutamate Receptor 7 Modulators in Cognitive Disorders	2
Correction to “Gossypetin Prevents the Progression of Nonalcoholic Steatohepatitis by Regulating Oxidative Stress and AMP-Activated Protein Kinase”	2
Deorphanization of G Protein Coupled Receptors: A Historical Perspective	2
Pharmacologic Characterization of LTGO-33, a Selective Small Molecule Inhibitor of the Voltage-Gated Sodium Channel NaV1.8 with a Unique Mechanism of Action	2
Correction to “A Novel Semisynthetic Inhibitor of the FRB Domain of Mammalian Target of Rapamycin Blocks Proliferation and Triggers Apoptosis in Chemoresistant Prostate Cancer Cells”	2
Effects of Small Molecule Ligands on ACKR3 Receptors	2
Pirin does not bind to p65 or regulate NFκB-dependent gene expression but does modulate cellular quercetin levels	2
Biasing Gβγ Downstream Signaling with Gallein Inhibits Development of Morphine Tolerance and Potentiates Morphine-Induced Nociception in a Tolerant State	2
Comparative evaluation of the biological characteristics of a novel retinoid X receptor agonist and bexarotene	2
Corrigendum to “Investigation of the binding mode of clobenprobit at CXCR4 and development of novel anti-inflammatory compounds with enhanced activity and minimal antagonist effects” [Molecular Pharma	2
Lubiprostone is a Non-Selective Activator of cAMP-Gated Ion Channels and Chloride Channel Protein 2 (Clc-2) Has a Minor Role in its Prosecretory Effect in Intestinal Epithelial Cells	2
Table of Contents	2
Signaling Specificity and Kinetics of the Human Metabotropic Glutamate Receptors	2
Amiodarone irrecoverably impairs the function of human ether-a-go-go-related gene potassium channels	2
Coexpressed δ-, μ-, and κ-Opioid Receptors Modulate Voltage-Gated Ca2+ Channels in Gastric-Projecting Vagal Afferent Neurons	2
Investigation of the binding mode of clobenprobit at CXCR4 and development of novel anti-inflammatory compounds with enhanced activity and minimal antagonist effects	2
Pharmacological Characterization of the Zebrafish (Danio Rerio) Histamine H1 Receptor Reveals the Involvement of the Second Extracellular Loop in the Binding of Histamine	2
Special Section on Therapeutic Implications for Sphingolipids in Health and Disease—Editorial	2
Differential Effects of Remdesivir and Lumacaftor on Homomeric and Heteromeric hERG Channels	2
Bioengineered miR-7-5p modulates non–small cell lung cancer cell metabolism to improve therapy	1
Synergy between Interleukin-1β, Interferon-γ, and Glucocorticoids to Induce TLR2 Expression Involves NF-κB, STAT1, and the Glucocorticoid Receptor	1
Mice carrying the human dopamine D2 receptor pathogenic mutation p.Met374Arg exhibit hyperactivity and aberrant D2 receptor function	1
Editorial Board	1
Discovery and Characterization of VU0542270, the First Selective Inhibitor of Vascular Kir6.1/SUR2B KATP Channels	1
The Potential Antidepressant Compound Org 34167 Modulates HCN Channels Via a Novel Mode of Action	1
Introduction of a single carboxylic acid converts the cyclic oligomeric depsipeptide ent-verticilide from a ryanodine receptor 2 (RyR2) inhibitor to RyR2 activator	1
Ion channels and G protein-coupled receptors: Cannabidiol actions on disorders of excitability and synaptic excitatory-inhibitory ratio	1
Extracellular ATP increases agonist potency and reduces latency at class B G protein-coupled receptors	1
Table of Contents	1
Inhibition of Tumor-Derived C-C Motif Chemokine Ligand 2 Expression Attenuates Tactile Allodynia in NCTC 2472 Fibrosarcoma-Inoculated Mice	1
Editorial Board	1
Protein Kinases and Cross-talk between Post-translational Modifications in the Regulation of Drug Transporters	1
Transient receptor potential vanilloid 3 activation accelerates keratinocyte migration in vitro but not dermal wound healing in vivo	1
Table of Contents	1
Design and evaluation of highly selective histone deacetylase 6 inhibitors derived from the natural product tryptoline	1
Allosteric Inhibition and Pharmacochaperoning of the Serotonin Transporter by the Antidepressant Drugs Trazodone and Nefazodone	1
Inhibition of the Aromatase Enzyme by Exemestane Cysteine Conjugates	1
Mechanisms for enhancement of μ-opioid receptor-mediated antinociception in the central nervous system through gallein-dependent modulation of downstream G protein βγ subunit signaling	1
Pharmacological characterization of a clinical candidate, TG-0054, a small molecule inverse agonist targeting CXCR4	1
Editorial Board	1
Emerging voices in G protein-coupled receptor biology	1
Inhibitory Actions of Potentiating Neuroactive Steroids in the Human α1β3γ2L γ-Aminobutyric Acid Type A Receptor	1
Table of Contents	1
Editorial Board	1
AKAP-scaffolded complexes and cyclic AMP signaling within the dorsal root ganglia in chronic pain	1
Liver CYP4A autophagic lysosomal degradation: A major role for the autophagic receptor SQSTM1/p62 through an uncommon target interaction site	1
Screening for Novel Type 2 Ryanodine Receptor Inhibitors by Endoplasmic Reticulum Ca2+ Monitoring	1
Expression of concern: “The Cyclopentenone Prostaglandin 15-Deoxy-delta12,14-Prostaglandin J2 Attenuates the Development of Acute and Chronic Inflammation” [Mol. Pharmacol. 2002; 61: 997-1007] by Cuzz	1
Intracellular Allosteric Antagonist of the Olfactory Receptor OR51E2	1
Determinants of Subtype-Selectivity of the Anthelmintic Paraherquamide A on Caenorhabditis elegans Nicotinic Acetylcholine Receptors	1
Functional Assessment of Cancer-Linked Mutations in Sensitive Regions of Regulators of G Protein Signaling Predicted by Three-Dimensional Missense Tolerance Ratio Analysis	1
Perspective: Therapeutic Implications for Sphingolipids in Health and Disease	1