Molecular Pharmacology

Article	Citations
Simplified Method for Kinetic and Thermodynamic Screening of Cardiotonic Steroids through the K+-Dependent Phosphatase Activity of Na+/K+-ATPase with Chromogenic pNPP Substrate	47
Fat traffic control: S-acylation in axonal transport	40
In Vitro Pharmacological Profile of KW-6356, a Novel Adenosine A2A Receptor Antagonist/Inverse Agonist	39
Expression of concern: “Adelmidrol, a Palmitoylethanolamide Analogue, as a New PharmacologicalTreatment for the Management of Inflammatory Bowel Disease” [Mol. Pharmacol. 2016; 90: 549-561] by Cordaro	38
UCM-A86 is a selective positive allosteric modulator of GluN1/GluN3 NMDA receptors	38
Enhancing remyelination in multiple sclerosis via M1 muscarinic acetylcholine receptor	38
A 19F-qNMR-Guided Mathematical Model for G Protein-Coupled Receptor Signaling	30
Structural Basis for the Allosteric Inhibition of Hypoxia-Inducible Factor 2 by Belzutifan	29
Editorial Board	28
Editorial Board	28
Isoprenaline shows unique kinase dependencies in stimulating β1AR–β-arrestin2 interaction compared to endogenous catecholamines	25
Development of a Novel Assay for Direct Assessment of Selective Amylin Receptor Activation Reveals Novel Differences in Behavior of Selective and Nonselective Peptide Agonists	20
Regulation of organic anion transporting polypeptide 1B1 transport function by concurrent phosphorylation and lysine-acetylation: A novel posttranslational regulation mechanism	19
Mechanism-based inactivation of human aldehyde oxidase by erlotinib: Mechanistic insights from structural analogs and molecular docking	17
Identification of potent and selective small molecule TALK-1 inhibitors that promote β-cell function.	17
Cholesterol residence time drives regulation of the G protein-coupled cholecystokinin receptor	17
Thermogenic Modulation of Adipose Depots: A Perspective on Possible Therapeutic Intervention with Early Cardiorenal Complications of Metabolic Impairment	17
St. John’s Wort Formulations Induce Rat CYP3A23-3A1 Independent of Their Hyperforin Content	16
Targeting Cyclophilin A and CD147 to Inhibit Replication of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) and SARS-CoV-2–Induced Inflammation	16
Local protein kinase A (PKA) signaling pathologies in the endocrine system	16
Editorial Board	15
GPR83 Engages Endogenous Peptides from Two Distinct Precursors to Elicit Differential Signaling	15
Discovery of RGS2-FBXO44 interaction inhibitors using a cell-based NanoBit assay	13
Resveratrol Binds Nuclear Receptor 4A1 (NR4A1) and Acts as an NR4A1 Antagonist in Lung Cancer Cells	13
Research approaches for exploring the hidden conversations of G protein-coupled receptor transactivation	13

The Emerging Structural Pharmacology of ATP-Sensitive Potassium Channels	13
Corrigendum to “Antitumor Effects of Dehydroxymethylepoxyquinomicin, a Novel Nuclear Factor-κB Inhibitor, in Human Liver Cancer Cells Are Mediated through a Reactive Oxygen Species-Dependent Mechanism	13
Pore Opening, Not Voltage Sensor Movement, Underpins the Voltage-Dependence of Facilitation by a hERG Blocker	13
Differential RELA and GR recruitment to the BIRC3/BIRC2 locus: Molecular insight as to combinatorial regulation by proinflammatory cytokines and glucocorticoid	12
Table of Contents	12
Role of HNF4A-AS1/HNRNPC-mediated HNF4A ubiquitination protection against ritonavir-induced hepatotoxicity	12
6,7-Dichloro-1H-indole-2,3-dione-3-oxime functions as a superagonist for the intermediate-conductance Ca2+-activated K+ channel KCa3.1	12
Emerging roles of ubiquitin-specific proteases in the cardiovascular system	12
BAY58-2667 Activates Different Soluble Guanylyl Cyclase Species by Distinct Mechanisms that Indicate Its Principal Target in Cells is the Heme-Free Soluble Guanylyl Cyclase-Heat Shock Protein 90 Compl	12
Corticosterone stimulates synthesis of 2-arachidonoylglycerol via putative membrane-bound glucocorticoid receptors and inhibits GABA release via CB1 cannabinoid receptors in the ventrolateral periaque	11
Commentary on the fourth Transatlantic G Protein-Coupled Receptor Symposium for early-career investigators	11
Distinctive patterns of G protein coupling induced by the structurally similar 5-HT2A receptor ligands ketanserin and altanserin in human prefrontal cortex	11
Correction to “A Brief Overview of the Toxic Sphingomyelinase Ds of Brown Recluse Spider Venom and Other Organisms and Simple Methods To Detect Production of Its Signature Cyclic Ceramide Phosphate”	11
Englerin A Inhibits T-Type Voltage-Gated Calcium Channels at Low Micromolar Concentrations	11
Correction to “Sulforaphane Suppresses Polycomb Group Protein Level via a Proteasome-Dependent Mechanism in Skin Cancer Cells”	11
Modulation of Kv7 Channel Currents by Echinocystic Acid	11
Rational design of biased G protein-coupled receptor agonists	11
Editorial Board	11
Table of Contents	11
A brief history of nerve action potentials after 1600	11
Corrigendum to “A subunit-selective negative allosteric modulator of GluN1/GluN3A glycine-activated receptor” [Molecular Pharmacology 108 (2026) 100104]	11
EP4 Receptor Conformation Sensor Suited for Ligand Screening and Imaging of Extracellular Prostaglandins	10
Discovery and In Vitro Characterization of BAY 2686013, an Allosteric Small Molecule Antagonist of the Human Pituitary Adenylate Cyclase-Activating Polypeptide Receptor	10
Editorial Board	10
The β2 adrenergic receptor cross-linked interactome identifies 14-3-3 proteins as regulating the availability of signaling-competent receptors	10
Gα Protein Signaling Bias at Serotonin 1A Receptor	10
Editorial Board	10
Expression of concern: “Caveolin-1 and Lipid Microdomains Regulate Gs Trafficking and Attenuate Gs/Adenylyl Cyclase Signaling” [Molecular Pharmacology, Volume 76, Issue 5, November 2009, Pages 1082-10	10
Repurposing lapatinib as a triple antagonist of chemokine receptors 3, 4, and 5	10
Contents	10
Corrigendum to “Novel Thiosemicarbazones Inhibit Lysine-Rich Carcinoembryonic Antigen-Related Cell Adhesion Molecule 1 (CEACAM1) Coisolated (LYRIC) and the LYRIC-Induced Epithelial- Mesenchymal Transi	10
The effects of hippocampal miR-34c-5p on the age-related discrepancies in susceptibility to traumatic stress in the post-traumatic stress disorder mice model	9
Going Rogue: Mechanisms, Regulation, and Roles of Mutationally Activated Gα in Human Cancer	9
Heterogeneous nuclear ribonucleoprotein A/B drives gastric cancer and epithelial-mesenchymal transition via the Akt-GSK3β-Wnt pathway	9
Predicting compounds that interact with the 2 known agonist-induced conformations of the human β1-adrenoceptor	9
Structural and Molecular Determinants of Glutamate Transporter Allosteric Modulators	8
β-Caryophyllene Inhibits Monoacylglycerol Lipase Activity and Increases 2-Arachidonoyl Glycerol Levels In Vivo: A New Mechanism of Endocannabinoid-Mediated Analgesia?	8
Editorial Board	8
Editorial Board	8
Corrigendum to “Targeting the Metastasis Suppressor, N-Myc Downstream Regulated Gene-1, with Novel Di-2- Pyridylketone Thiosemicarbazones: Suppression of Tumor Cell Migration and Cell-Collagen Adhesio	7
Development of an LC-MS/MS Method to Measure Sphingolipids in CSF from Patients with Multiple Sclerosis	7
The Glycosylated N-Terminal Domain of MUC1 Is Involved in Chemoresistance by Modulating Drug Permeation Across the Plasma Membrane	7
Insights Into the Differential Desensitization of α4β2 Nicotinic Acetylcholine Receptor Isoforms Obtained With Positive Allosteric Modulation of Mutant Receptors	7
Table of Contents	7
Corrigendum to “The Natural Compound Withaferin A Covalently Binds to Cys239 of β-Tubulin to Promote Tubulin Degradation”	7
The M3 Muscarinic Acetylcholine Receptor Can Signal through Multiple G Protein Families	7
Induced Fit Describes Ligand Binding to Membrane-Associated Cytochrome P450 3A4	7
Table of Contents	7
GRK2 and GRK5—The 2 critical kinases in cardiac pathophysiology	7
A Novel Role of Uricosuric Agent Benzbromarone in BK Channel Activation and Reduction of Airway Smooth Muscle Contraction	7

Editorial Board	7
Cepharanthine, a valuable sanative alternative for hepatocellular carcinoma through regulating Hippo-Yes-associated protein signal transduction	6
N-(4-Bromo-2,5-Dimethoxyphenethyl)-6-(4-Phenylbutoxy)Hexan-1-Amine (XOB): A Novel Phenylalkylamine Antagonist of Serotonin 2A Receptors and Voltage-Gated Sodium Channels	6
Electrophysiological characterization of the state-dependent inhibition of Kv7.1 and IKs by UCL2077	6
Upregulating vascular endothelial KCa2.3 channels alleviates pulmonary hypertension in mice	6
Aryl Hydrocarbon Receptor as a Therapeutical Target of Environmentally Induced Skin Conditions	6
Loss of α-cell GRK2 modulates glucagon response and supports cardiac function	6
Pharmacological Targeting of Senescence with Senolytics as a New Therapeutic Strategy for Neurodegeneration	6
The thiazolidinedione drug troglitazone inhibits Gq signaling through direct binding to the Gq alpha subunit through inhibition of GDP release	6
Pharmacological Characterization and Radiolabeling of VUF15485, a High-Affinity Small-Molecule Agonist for the Atypical Chemokine Receptor ACKR3	6
Activation of TRPV3 channels in bladder cancer cells stimulates ATP release	6
Elucidating the binding and metabolic interactions of sunitinib and sorafenib with Cytochrome P450s CYP2U1 and CYP2D6	6
Elucidating molecular mechanisms governing tumor necrosis factor-alpha–mediated regulation of amyloid beta 42 uptake in blood-brain barrier endothelial cells	6
Inhibition of Cardiac Kv4.3/KChIP2 Channels by Sulfonylurea Drug Gliquidone	6
Editorial Board	5
Expression of Ceramide Synthases in Mice and Their Roles in Regulating Acyl-Chain Sphingolipids: A Framework for Baseline Levels and Future Implications in Aging and Disease	5
Amyloid-Beta Peptides 40 and 42 Employ Distinct Molecular Pathways for Cell Entry and Intracellular Transit at the Blood–Brain Barrier Endothelium	5
Table of Contents	5
Fanning the Flames of Endoplasmic Reticulum (ER) Stress: Can Sphingolipid Metabolism Be Targeted to Enhance ER Stress–Associated Immunogenic Cell Death in Cancer?	5
Role of Mitochondrial and Cytosolic Folylpolyglutamate Synthetase in One-Carbon Metabolism and Antitumor Efficacy of Mitochondrial-Targeted Antifolates	5
The Common LncRNAs of Neuroinflammation-Related Diseases	5
Drugs Form Ternary Complexes with Human Liver Fatty Acid Binding Protein 1 (FABP1) and FABP1 Binding Alters Drug Metabolism	5
Editorial Board	5
Circumvention of Topoisomerase IIα Intron 19 Intronic Polyadenylation in Acquired Etoposide-Resistant Human Leukemia K562 Cells	5
Molecular determinants of 2-aminoethoxydiphenyl borate sensitivity of transient receptor potential vanilloid 2-unexpected differences between 2 rodent orthologs	5
Multiomics Analyses Identify Proline Endopeptidase–Like Protein As a Key Regulator of Protein Trafficking, a Pathway Underlying Alzheimer’s Disease Pathogenesis	5
A Sentimental Segue	5
HDAC6 inhibition ameliorates sensory hypersensitivity and reduces immune cell signatures in the dorsal root ganglia in murine chronic pain models	5
Mechanisms of Action Underlying Conductance-Modifying Positive Allosteric Modulators of the NMDA Receptor	5
Substituted Cysteine Modification and Protection with n-Alkyl-MTS Reagents Quantifies Steric Changes Induced by a Mutation in Anesthetic Binding Sites on GABA Type A Receptors	4
Upacicalcet Is a Novel Secondary Hyperparathyroidism Drug that Targets the Amino Acid Binding Site of Calcium-Sensing Receptor	4
State-Dependent Inhibition of Nav1.8 Sodium Channels by VX-150 and VX-548	4
Editorial Board	4
Effects of two structurally diverse positive allosteric modulators on signaling bias at the μ-opioid receptor	4
Editorial Board	4
Evaluation of allosteric N-methyl-d-aspartate receptor modulation by GluN2A-selective antagonists using pharmacological equilibrium modeling	4
Coassembly of Warm Temperature–Sensitive Transient Receptor Potential Vanilloid (TRPV) 3 and TRPV4 Channel Complexes with Distinct Functional Properties	4
Ca2+/calmodulin-dependent inhibitors of adenylyl cyclase 1 as novel nonopioid analgesics for chronic inflammatory pain	4
Differential Activity of Orthosteric Agonists and Allosteric Modulators at Metabotropic Glutamate Receptor 7	4
A Constitutive EGFR Kinase Dimer to Study Inhibitor Pharmacology	4
Screening and Identification of a Novel Anti–Siglec-15 Human Antibody 3F1 and Relevant Antitumor Activity	4
Interaction between W41 of the hepatitis B virus preS1 surface peptide and Y146/F274 of the cellular receptor molecule Na+/taurocholate co-transporting polypeptide is essential for virus entry	4
Voltage sensor interaction site for a selective small molecule Nav1.1 sodium channel potentiator that enhances firing of fast-spiking interneurons	4
Table of Contents	4
Development of a Selective and High Affinity Radioligand, [3H]VU6013720, for the M4 Muscarinic Receptor	4
The peroxisome proliferator–activated receptor α/β/γ agonist NCPC-626 from microbial metabolites alleviates metabolic dysfunction–associated steatohepatitis in mice	3
Rare variant in intracellular loop-2 alters the spatial distribution and transducer coupling selectivity of the ghrelin receptor	3
Influence of Tyrosine Kinase Inhibition on Organic Anion Transporting Polypeptide 1B3-Mediated Uptake	3
G protein-coupled receptor–targeted proteolysis-targeting chimeras in cancer therapeutics	3
Chemokine receptors – Exemplifying functional divergence in G protein-coupled receptors	3
The CaMKII D135N mutation blocks kinase activity and reduces GluN2B binding	3
Corrigendum to “Functional Interaction between Transient Receptor Potential V4 Channel and Neuronal Calcium Sensor 1 and the Effects of Paclitaxel”	3
Extrachromosomal Circular DNAs, Amplified Oncogenes, and CRISPR-Cas9 System	3
Correction to “Neratinib Reverses ATP-Binding Cassette B1-Mediated Chemotherapeutic Drug Resistance In Vitro, In Vivo, and Ex Vivo”	3
Dual nuclear receptor 4A1 (NR4A1/NR4A2) ligands inhibit glioblastoma growth and target TWIST1	3
Role of GPR55 in glutamatergic and dopaminergic signalling: a review of preclinical evidence in neuropsychiatric disorders	3
New Mechanisms Underlying Oncogenesis in Dbl Family Rho Guanine Nucleotide Exchange Factors	3
Transcriptional Regulation, Signaling Pathways, and Subcellular Localization of Corticotropin-Releasing Factor Receptors in the Central Nervous System	3
Editorial Board	3
A machine learning–based analysis method for small molecule high content screening of three-dimensional cancer spheroid morphology	3
Table of Contents	3
Multiwalled carbon nanotubes activate the NLRP3 inflammasome-dependent pyroptosis in macrophages	3
Corrigendum to “Repurposing Treprostinil for Enhancing Hematopoietic Progenitor Cell Transplantation”	3
Molecular and cellular effects of hydroxy-1,4 naphthoquinones used in dermatological and cosmetic applications on human protein tyrosine phosphatase PTP1B in human keratinocytes	3
Cyclovirobuxine inhibits ferroptosis to mitigate Alzheimer disease in glutamate-induced SH-SY5Y cell: the role of the liquid-liquid phase separation of FTH1	3
Agonists of the Nuclear Receptor PPARγ Can Produce Biased Signaling	3
Passive Immunotherapies Targeting Amyloid-β in Alzheimer’s Disease: A Quantitative Systems Pharmacology Perspective	3
Contents	3
Alkannin Attenuates Amyloid β Aggregation and Alzheimer’s Disease Pathology	3
Atypical Chemokine Receptor 3 “Senses” CXC Chemokine Receptor 4 Activation Through GPCR Kinase Phosphorylation	3
Cannabinoid receptor 2 activating antibodies: A promising therapeutic strategy for macrophage-driven fibro-inflammatory diseases	3
The Small Molecule Antagonist KCI807 Disrupts Association of the Amino-Terminal Domain of the Androgen Receptor with ELK1 by Modulating the Adjacent DNA Binding Domain	3
Ketamine and Major Ketamine Metabolites Function as Allosteric Modulators of Opioid Receptors	2
Coexpressed δ-, μ-, and κ-Opioid Receptors Modulate Voltage-Gated Ca2+ Channels in Gastric-Projecting Vagal Afferent Neurons	2
Transient receptor potential vanilloid 3 activation accelerates keratinocyte migration in vitro but not dermal wound healing in vivo	2
Differential Effects of Remdesivir and Lumacaftor on Homomeric and Heteromeric hERG Channels	2
Bioengineered miR-7-5p modulates non–small cell lung cancer cell metabolism to improve therapy	2
Correction to “Gossypetin Prevents the Progression of Nonalcoholic Steatohepatitis by Regulating Oxidative Stress and AMP-Activated Protein Kinase”	2
Signaling Specificity and Kinetics of the Human Metabotropic Glutamate Receptors	2
Amiodarone irrecoverably impairs the function of human ether-a-go-go-related gene potassium channels	2

Voltage sensors	2
Editorial Board	2
Comparative evaluation of the biological characteristics of a novel retinoid X receptor agonist and bexarotene	2
Inhibition of Tumor-Derived C-C Motif Chemokine Ligand 2 Expression Attenuates Tactile Allodynia in NCTC 2472 Fibrosarcoma-Inoculated Mice	2
Special Section on Therapeutic Implications for Sphingolipids in Health and Disease—Editorial	2
Corrigendum to “Investigation of the binding mode of clobenprobit at CXCR4 and development of novel anti-inflammatory compounds with enhanced activity and minimal antagonist effects” [Molecular Pharma	2
Correction to “A Novel Semisynthetic Inhibitor of the FRB Domain of Mammalian Target of Rapamycin Blocks Proliferation and Triggers Apoptosis in Chemoresistant Prostate Cancer Cells”	2
Pirin does not bind to p65 or regulate NFκB-dependent gene expression but does modulate cellular quercetin levels	2
Biasing Gβγ Downstream Signaling with Gallein Inhibits Development of Morphine Tolerance and Potentiates Morphine-Induced Nociception in a Tolerant State	2
Table of Contents	2
Rescue of Familial Lecithin:Cholesterol Acyltranferase Deficiency Mutations with an Allosteric Activator	2
Lubiprostone is a Non-Selective Activator of cAMP-Gated Ion Channels and Chloride Channel Protein 2 (Clc-2) Has a Minor Role in its Prosecretory Effect in Intestinal Epithelial Cells	2
Table of Contents	2
Deorphanization of G Protein Coupled Receptors: A Historical Perspective	2
Investigation of the binding mode of clobenprobit at CXCR4 and development of novel anti-inflammatory compounds with enhanced activity and minimal antagonist effects	2
Pharmacological Characterization of the Zebrafish (Danio Rerio) Histamine H1 Receptor Reveals the Involvement of the Second Extracellular Loop in the Binding of Histamine	2
Effects of Small Molecule Ligands on ACKR3 Receptors	2
Therapeutic Potential for Metabotropic Glutamate Receptor 7 Modulators in Cognitive Disorders	2
Receptor Determinants for β-Arrestin Functional Specificity at C-X-C Chemokine Receptor 5	2
Pharmacologic Characterization of LTGO-33, a Selective Small Molecule Inhibitor of the Voltage-Gated Sodium Channel NaV1.8 with a Unique Mechanism of Action	1
Synergy between Interleukin-1β, Interferon-γ, and Glucocorticoids to Induce TLR2 Expression Involves NF-κB, STAT1, and the Glucocorticoid Receptor	1
Table of Contents	1
The Potential Antidepressant Compound Org 34167 Modulates HCN Channels Via a Novel Mode of Action	1
Table of Contents	1
Expression of concern: “The Cyclopentenone Prostaglandin 15-Deoxy-delta12,14-Prostaglandin J2 Attenuates the Development of Acute and Chronic Inflammation” [Mol. Pharmacol. 2002; 61: 997-1007] by Cuzz	1
Editorial Board	1
Mechanisms for enhancement of μ-opioid receptor-mediated antinociception in the central nervous system through gallein-dependent modulation of downstream G protein βγ subunit signaling	1
Ion channels and G protein-coupled receptors: Cannabidiol actions on disorders of excitability and synaptic excitatory-inhibitory ratio	1
Pharmacological characterization of a clinical candidate, TG-0054, a small molecule inverse agonist targeting CXCR4	1
Table of Contents	1
Intracellular Allosteric Antagonist of the Olfactory Receptor OR51E2	1
Emerging voices in G protein-coupled receptor biology	1
Editorial Board	1
Discovery and Characterization of VU0542270, the First Selective Inhibitor of Vascular Kir6.1/SUR2B KATP Channels	1
Design and evaluation of highly selective histone deacetylase 6 inhibitors derived from the natural product tryptoline	1
Introduction of a single carboxylic acid converts the cyclic oligomeric depsipeptide ent-verticilide from a ryanodine receptor 2 (RyR2) inhibitor to RyR2 activator	1
Inhibitory Actions of Potentiating Neuroactive Steroids in the Human α1β3γ2L γ-Aminobutyric Acid Type A Receptor	1
Protein Kinases and Cross-talk between Post-translational Modifications in the Regulation of Drug Transporters	1
Discovery of Novel Activators of Large-Conductance Calcium-Activated Potassium Channels for the Treatment of Cerebellar Ataxia	1
Editorial Board	1
Perspective: Therapeutic Implications for Sphingolipids in Health and Disease	1
Functional Assessment of Cancer-Linked Mutations in Sensitive Regions of Regulators of G Protein Signaling Predicted by Three-Dimensional Missense Tolerance Ratio Analysis	1
Editorial Board	1
Screening for Novel Type 2 Ryanodine Receptor Inhibitors by Endoplasmic Reticulum Ca2+ Monitoring	1
Inhibition of the Aromatase Enzyme by Exemestane Cysteine Conjugates	1
Liver CYP4A autophagic lysosomal degradation: A major role for the autophagic receptor SQSTM1/p62 through an uncommon target interaction site	1
Extracellular ATP increases agonist potency and reduces latency at class B G protein-coupled receptors	1
Determinants of Subtype-Selectivity of the Anthelmintic Paraherquamide A on Caenorhabditis elegans Nicotinic Acetylcholine Receptors	1
Table of Contents	1