OOIR: Observatory of International Research

Papers

(The H4-Index of Life Sciences is 56. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-12-01 to 2025-12-01.)

Article	Citations
Characterizing COPD phenotypes with a targeted signaling lipids metabolomics approach	396
Carboxyaminotriazole: A bone savior in collagen-induced arthritis—Halting osteoclastogenesis via interleukin-1β downregulation	249
Cigarette smoking-related OLC1 overexpression associated with poor prognosis in bladder urothelial carcinoma	234
Cross-species gene expression patterns of purinergic signaling in the human and mouse trigeminal ganglion	204
PEG-4000 formed polymeric nanoparticles loaded with cetuximab downregulate p21 & stathmin-1 gene expression in cancer cell lines	180
CpG-mediated TLR9 signaling pathway enhances the efficacy of the OprF/PcrV DNA vaccine with cGAS-STING-activating properties	167
Repurposing therapeutics for malignant pleural mesothelioma (MPM) – Updates on clinical translations and future outlook	162
The inhibition of autophagy by spautin boosts the anticancer activity of fingolimod in multidrug-resistant hepatocellular carcinoma	136
Altering phosphorylation of dystrophin S3059 to attenuate cancer cachexia	136
Sulforaphane regulates Nrf2-mediated antioxidant activity and downregulates TGF-β1/Smad pathways to prevent radiation-induced muscle fibrosis	109
γ-Aminobutyric acid promotes the inhibition of hair growth induced by chronic restraint stress	101
Environmental bacteria as triggers to brain disease: Possible mechanisms of toxicity and associated human risk	92
The proteomic landscape of ovarian cancer cells in response to melatonin	87
The chromatin remodeling protein BRG1 mediates Ang II induced pro-fibrogenic response in renal fibroblasts	86
4-Methylumbelliferone induces antitumor effects independently of hyaluronan synthesis inhibition in human acute leukemia cell lines	83
Rhein ameliorates septic lung injury and intervenes in macrophage metabolic reprogramming in the inflammatory state by Sirtuin 1	83
A detailed insight into macrophages' role in shaping lung carcinogenesis	81
Editorial Board	78
Retraction notice to “Inhibition of CD73 using folate targeted nanoparticles carrying anti-CD73 siRNA potentiates anticancer efficacy of Dinaciclib” [Life Sci. 259 (2020) 118150]	76
Ablation of Brg1 in fibroblast/myofibroblast lineages attenuates renal fibrosis in mice with diabetic nephropathy	75
Hyperglycemia influences the cell proliferation and death of the rat endocrine pancreas in the neonatal period	75
Ivabradine restores tonic cardiovascular autonomic control and reduces tachycardia, hypertension and left ventricular inflammation in post-weaning protein malnourished rats	74
Insights into the development of insulin-producing cells: Precursors correlated involvement of microRNA panels	73
The dynamicity of mutant KRAS β2 strand modulates its downstream activation and predicts anticancer KRAS inhibition	72
Photothermal therapy-mediated autophagy in breast cancer treatment: Progress and trends	72

Dehydroepiandrosterone activates the GPER-mediated AMPK signaling pathway to alleviate the oxidative stress and inflammatory response in laying hens fed with high-energy and low-protein diets	71
Augmented nephroprotective effect of liraglutide and rabeprazole via inhibition of OCT2 transporter in cisplatin-induced nephrotoxicity in rats	71
Metacaspase (Pf MCA-1) as antimalarial drug target: An in silico approach and their biological validation	70
Behavioural disruption in diabetic mice: Neurobiological correlates and influences of dietary α-linolenic acid	70
Integrin αvβ3 and disulfide bonds play important roles in NGR-retargeted adenovirus transduction efficiency	70
Targeting GAS6/AXL signaling improves the response to immunotherapy by restoring the anti-immunogenic tumor microenvironment in gastric cancer	69
Progesterone signaling in uterine fibroids: Molecular mechanisms and therapeutic opportunities	68
Lung cancer vaccination from concept to reality: A critical review of clinical trials and latest advances	66
Upregulation of miR-222-3p alleviates the symptom of aortic dissection through targeting STAT3	64
6-NitroDopamine is an endogenous modulator of rat heart chronotropism	64
Targeting HMG-CoA synthase 2 suppresses tamoxifen-resistant breast cancer growth by augmenting mitochondrial oxidative stress-mediated cell death	64
The role of endoplasmic reticulum aminopeptidases in type 1 diabetes mellitus	64
Regulation of metabolism by circadian rhythms: Support from time-restricted eating, intestinal microbiota & omics analysis	63
Encapsulated mesenchymal stem cell-derived exosomes promote optic nerve regeneration and functional recovery in a mouse model of optic nerve crush injury	62
The role of exosomes in the molecular mechanisms of metastasis: Focusing on EMT and cancer stem cells	62
Effect of folate-targeted Erlotinib loaded human serum albumin nanoparticles on tumor size and survival rate in a rat model of glioblastoma	62
Tuberous sclerosis complex 2 deficiency in cardiomyocytes exacerbates cardiac remodeling in diabetic mice	61
Molecular insights into the causal role of TG/IDL in rheumatoid arthritis: Integrating Mendelian randomization and single-cell RNA sequencing	61
The combined therapy of mesenchymal stem cell transplantation and resveratrol for diabetes: Future applications and challenges	60
High fat diet exacerbates long-term metabolic, neuropathological, and behavioral derangements in an experimental mouse model of traumatic brain injury	59
Suppression of PCSK9/NF-kB-dependent pathways by acetate ameliorates cardiac inflammation in a rat model of polycystic ovarian syndrome	58
Melatonin: A potential protective multifaceted force for sepsis-induced cardiomyopathy	58
The combination of mesenchymal stem cell- and hepatocyte-derived exosomes, along with imipenem, ameliorates inflammatory responses and liver damage in a sepsis mouse model	58
Autophagy deficiency exacerbated hypoxia-reoxygenation induced inflammation and cell death via a mitochondrial DNA/STING/IRF3 pathway	58
The N6-methyladenosine modification in pathologic angiogenesis	58
Coadministration of olanzapine causes minor impacts on the diabetogenic outcomes induced by dexamethasone treatment in rats	58
Emerging therapeutic landscape: Incretin agonists in chronic kidney disease management	57
Dysregulated pancreatic lipid phenotype, inflammation and cellular injury in a chronic ethanol feeding model of hepatic alcohol dehydrogenase-deficient deer mice	57
Ergosterol promotes neurite outgrowth, inhibits amyloid-beta synthesis, and extends longevity: In vitro neuroblastoma and in vivo Caenorhabditis elegans evidence	57
Liraglutide attenuates intestinal ischemia/reperfusion injury via NF-κB and PI3K/Akt pathways in mice	56
Mebendazole; from an anti-parasitic drug to a promising candidate for drug repurposing in colorectal cancer	56
Human gestational diabetes mellitus–derived exosomes impair glucose homeostasis in pregnant mice and stimulate functional maturation of offspring-islets	56