OOIR: Observatory of International Research

Papers

(The H4-Index of Life Sciences is 54. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-09-01 to 2025-09-01.)

Article	Citations
Insights into the development of insulin-producing cells: Precursors correlated involvement of microRNA panels	366
Behavioural disruption in diabetic mice: Neurobiological correlates and influences of dietary α-linolenic acid	345
Skp2-mediated Zeb1 expression facilitates cancer migration by a ubiquitination-independent pathway	225
Targeting GAS6/AXL signaling improves the response to immunotherapy by restoring the anti-immunogenic tumor microenvironment in gastric cancer	206
Cross-species gene expression patterns of purinergic signaling in the human and mouse trigeminal ganglion	163
Cigarette smoking-related OLC1 overexpression associated with poor prognosis in bladder urothelial carcinoma	152
The proteomic landscape of ovarian cancer cells in response to melatonin	149
Optimal intervention time of ADSCs for hepatic ischemia-reperfusion combined with partial resection injury in rats	146
Transcranial alternating current stimulation inhibits ferroptosis and promotes functional recovery in spinal cord injury via the cGMP-PKG signalling pathway	145
Emerging therapeutic landscape: Incretin agonists in chronic kidney disease management	138
A detailed insight into macrophages' role in shaping lung carcinogenesis	126
The inhibition of autophagy by spautin boosts the anticancer activity of fingolimod in multidrug-resistant hepatocellular carcinoma	112
Ergosterol promotes neurite outgrowth, inhibits amyloid-beta synthesis, and extends longevity: In vitro neuroblastoma and in vivo Caenorhabditis elegans evidence	108
Combined effects of high fat diet and exercise on autophagy in white adipose tissue of mice	101
Carboxyaminotriazole: A bone savior in collagen-induced arthritis—Halting osteoclastogenesis via interleukin-1β downregulation	92
Characterizing COPD phenotypes with a targeted signaling lipids metabolomics approach	89
Editorial Board	85
Hyperglycemia influences the cell proliferation and death of the rat endocrine pancreas in the neonatal period	85
The dynamicity of mutant KRAS β2 strand modulates its downstream activation and predicts anticancer KRAS inhibition	84
The chromatin remodeling protein BRG1 mediates Ang II induced pro-fibrogenic response in renal fibroblasts	76
Environmental bacteria as triggers to brain disease: Possible mechanisms of toxicity and associated human risk	75
Retraction notice to “Inhibition of CD73 using folate targeted nanoparticles carrying anti-CD73 siRNA potentiates anticancer efficacy of Dinaciclib” [Life Sci. 259 (2020) 118150]	73
CKN reduces TLR4-mediated inflammation and cerebral I/R injury by activating the LXRα/ABCA1 pathway in microglia	70
γ-Aminobutyric acid promotes the inhibition of hair growth induced by chronic restraint stress	70
Preclinical metabolic characterization of mefunidone, a novel anti-renal fibrosis drug	70

Metacaspase (Pf MCA-1) as antimalarial drug target: An in silico approach and their biological validation	70
Integrin αvβ3 and disulfide bonds play important roles in NGR-retargeted adenovirus transduction efficiency	70
Sulforaphane regulates Nrf2-mediated antioxidant activity and downregulates TGF-β1/Smad pathways to prevent radiation-induced muscle fibrosis	70
Repurposing therapeutics for malignant pleural mesothelioma (MPM) – Updates on clinical translations and future outlook	69
Antioxidant therapy reverses sympathetic dysfunction, oxidative stress, and hypertension in male hyperadipose rats	68
The C C motif chemokine ligand 11 contributes to alcoholic liver disease	67
High fat diet exacerbates long-term metabolic, neuropathological, and behavioral derangements in an experimental mouse model of traumatic brain injury	67
Rhein ameliorates septic lung injury and intervenes in macrophage metabolic reprogramming in the inflammatory state by Sirtuin 1	66
Augmented nephroprotective effect of liraglutide and rabeprazole via inhibition of OCT2 transporter in cisplatin-induced nephrotoxicity in rats	65
Spontaneous and familial models of Alzheimer's disease: Challenges and advances in preclinical research	65
Suppression of PCSK9/NF-kB-dependent pathways by acetate ameliorates cardiac inflammation in a rat model of polycystic ovarian syndrome	64
Exploring Lin28 proteins: Unravelling structure and functions with emphasis on nervous system malignancies	64
Targeting HMG-CoA synthase 2 suppresses tamoxifen-resistant breast cancer growth by augmenting mitochondrial oxidative stress-mediated cell death	62
Carvacrol enhances anti-tumor activity and mitigates cardiotoxicity of sorafenib in thioacetamide-induced hepatocellular carcinoma model through inhibiting TRPM7	61
4-Methylumbelliferone induces antitumor effects independently of hyaluronan synthesis inhibition in human acute leukemia cell lines	61
PEG-4000 formed polymeric nanoparticles loaded with cetuximab downregulate p21 & stathmin-1 gene expression in cancer cell lines	61
Exercise training and probiotic supplementation effects on skeletal muscle apoptosis prevention in type-Ι diabetic rats	61
Photothermal therapy-mediated autophagy in breast cancer treatment: Progress and trends	59
Mebendazole; from an anti-parasitic drug to a promising candidate for drug repurposing in colorectal cancer	58
The role of exosomes in the molecular mechanisms of metastasis: Focusing on EMT and cancer stem cells	58
Upregulation of miR-222-3p alleviates the symptom of aortic dissection through targeting STAT3	58
Lung cancer vaccination from concept to reality: A critical review of clinical trials and latest advances	58
Dysregulated pancreatic lipid phenotype, inflammation and cellular injury in a chronic ethanol feeding model of hepatic alcohol dehydrogenase-deficient deer mice	58
Targeting pyruvate kinase muscle isoform 2 (PKM2) in cancer: What do we know so far?	57
Renal protective effects and mechanisms of the angiotensin receptor-neprilysin inhibitor LCZ696 in mice with cardiorenal syndrome	56
Unleashing the pathological imprinting of cancer in autoimmunity: Is ZEB1 the answer?	56
Mitochondrial transfer in the progression and treatment of cardiac disease	56
Myeloid derived suppressor cells and innate immune system interaction in tumor microenvironment	56
Application of f-FeNC@GOx cascade enzyme nanomaterials in the healing of infected wounds	55
Progesterone signaling in uterine fibroids: Molecular mechanisms and therapeutic opportunities	54