OOIR: Observatory of International Research

Papers

(The H4-Index of Life Sciences is 58. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-06-01 to 2026-06-01.)

Article	Citations
Cigarette smoking-related OLC1 overexpression associated with poor prognosis in bladder urothelial carcinoma	282
Cross-species gene expression patterns of purinergic signaling in the human and mouse trigeminal ganglion	265
The role of exosomes in the molecular mechanisms of metastasis: Focusing on EMT and cancer stem cells	207
Encapsulated mesenchymal stem cell-derived exosomes promote optic nerve regeneration and functional recovery in a mouse model of optic nerve crush injury	189
Upregulation of miR-222-3p alleviates the symptom of aortic dissection through targeting STAT3	121
The combination of mesenchymal stem cell- and hepatocyte-derived exosomes, along with imipenem, ameliorates inflammatory responses and liver damage in a sepsis mouse model	121
Skp2-mediated Zeb1 expression facilitates cancer migration by a ubiquitination-independent pathway	112
γ-Aminobutyric acid promotes the inhibition of hair growth induced by chronic restraint stress	111
The inhibition of autophagy by spautin boosts the anticancer activity of fingolimod in multidrug-resistant hepatocellular carcinoma	111
A detailed insight into macrophages' role in shaping lung carcinogenesis	110
Editorial Board	93
Hyperglycemia influences the cell proliferation and death of the rat endocrine pancreas in the neonatal period	91
Ablation of Brg1 in fibroblast/myofibroblast lineages attenuates renal fibrosis in mice with diabetic nephropathy	89
Ivabradine restores tonic cardiovascular autonomic control and reduces tachycardia, hypertension and left ventricular inflammation in post-weaning protein malnourished rats	89
The dynamicity of mutant KRAS β2 strand modulates its downstream activation and predicts anticancer KRAS inhibition	88
The C C motif chemokine ligand 11 contributes to alcoholic liver disease	87
Human gestational diabetes mellitus–derived exosomes impair glucose homeostasis in pregnant mice and stimulate functional maturation of offspring-islets	87
Application of f-FeNC@GOx cascade enzyme nanomaterials in the healing of infected wounds	86
Insights into the development of insulin-producing cells: Precursors correlated involvement of microRNA panels	85
Liraglutide attenuates intestinal ischemia/reperfusion injury via NF-κB and PI3K/Akt pathways in mice	85
Effect of folate-targeted Erlotinib loaded human serum albumin nanoparticles on tumor size and survival rate in a rat model of glioblastoma	85
Melatonin: A potential protective multifaceted force for sepsis-induced cardiomyopathy	84
Carboxyaminotriazole: A bone savior in collagen-induced arthritis—Halting osteoclastogenesis via interleukin-1β downregulation	82
Retraction notice to “Inhibition of CD73 using folate targeted nanoparticles carrying anti-CD73 siRNA potentiates anticancer efficacy of Dinaciclib” [Life Sci. 259 (2020) 118150]	82
The N6-methyladenosine modification in pathologic angiogenesis	81

Molecular insights into the causal role of TG/IDL in rheumatoid arthritis: Integrating Mendelian randomization and single-cell RNA sequencing	81
Lung cancer vaccination from concept to reality: A critical review of clinical trials and latest advances	77
HDAC11 deficiency improves muscle phenotype in a Duchenne muscular dystrophy murine model by reducing inflammation and fibrosis	77
Repurposing therapeutics for malignant pleural mesothelioma (MPM) – Updates on clinical translations and future outlook	76
Transcranial alternating current stimulation inhibits ferroptosis and promotes functional recovery in spinal cord injury via the cGMP-PKG signalling pathway	75
Characterizing COPD phenotypes with a targeted signaling lipids metabolomics approach	75
Coadministration of olanzapine causes minor impacts on the diabetogenic outcomes induced by dexamethasone treatment in rats	73
Protective role of ellagic acid and taurine against fluoxetine induced hepatotoxic effects on biochemical and oxidative stress parameters, histopathological changes, and gene expressions of IL-1β, NF-	73
Dehydroepiandrosterone activates the GPER-mediated AMPK signaling pathway to alleviate the oxidative stress and inflammatory response in laying hens fed with high-energy and low-protein diets	72
The combined therapy of mesenchymal stem cell transplantation and resveratrol for diabetes: Future applications and challenges	72
Photothermal therapy-mediated autophagy in breast cancer treatment: Progress and trends	71
The role of endoplasmic reticulum aminopeptidases in type 1 diabetes mellitus	71
Metacaspase (Pf MCA-1) as antimalarial drug target: An in silico approach and their biological validation	70
The chromatin remodeling protein BRG1 mediates Ang II induced pro-fibrogenic response in renal fibroblasts	68
CKN reduces TLR4-mediated inflammation and cerebral I/R injury by activating the LXRα/ABCA1 pathway in microglia	68
Altering phosphorylation of dystrophin S3059 to attenuate cancer cachexia	66
Screening strategy using a filamentous fungus model to repurpose drugs for mitochondrial complex I deficiencies	65
Suppression of PCSK9/NF-kB-dependent pathways by acetate ameliorates cardiac inflammation in a rat model of polycystic ovarian syndrome	65
Ergosterol promotes neurite outgrowth, inhibits amyloid-beta synthesis, and extends longevity: In vitro neuroblastoma and in vivo Caenorhabditis elegans evidence	64
Role of left and right vagus nerves in linking peripheral adrenergic signals to contextual fear memory	64
Tuberous sclerosis complex 2 deficiency in cardiomyocytes exacerbates cardiac remodeling in diabetic mice	64
Environmental bacteria as triggers to brain disease: Possible mechanisms of toxicity and associated human risk	63
Myeloid derived suppressor cells and innate immune system interaction in tumor microenvironment	62
CpG-mediated TLR9 signaling pathway enhances the efficacy of the OprF/PcrV DNA vaccine with cGAS-STING-activating properties	61
Metabolomics profiling and chemoresistance mechanisms in ovarian cancer cell lines: Implications for targeting glutathione pathway	60
TRIM21 ubiquitylates GPX4 and promotes ferroptosis to aggravate ischemia/reperfusion-induced acute kidney injury	60
Targeting GAS6/AXL signaling improves the response to immunotherapy by restoring the anti-immunogenic tumor microenvironment in gastric cancer	60
Rhein ameliorates septic lung injury and intervenes in macrophage metabolic reprogramming in the inflammatory state by Sirtuin 1	60
Mitochondrial transfer in the progression and treatment of cardiac disease	59
Progesterone signaling in uterine fibroids: Molecular mechanisms and therapeutic opportunities	59
Sulforaphane regulates Nrf2-mediated antioxidant activity and downregulates TGF-β1/Smad pathways to prevent radiation-induced muscle fibrosis	59
Spontaneous and familial models of Alzheimer's disease: Challenges and advances in preclinical research	59
Fluid shear stress facilitates prostate cancer metastasis through Piezo1-Src-YAP axis	59