Laboratory Investigation

Article	Citations
Artificial intelligence and computational pathology	173
Bone marrow mesenchymal stem cell-derived exosomal miR-144-5p improves rat ovarian function after chemotherapy-induced ovarian failure by targeting PTEN	97
PI3K-Akt-mTOR/PFKFB3 pathway mediated lung fibroblast aerobic glycolysis and collagen synthesis in lipopolysaccharide-induced pulmonary fibrosis	79
CCL8 secreted by tumor-associated macrophages promotes invasion and stemness of glioblastoma cells via ERK1/2 signaling	73
Detection of SARS-CoV-2 in formalin-fixed paraffin-embedded tissue sections using commercially available reagents	70
Retrospective analysis of laboratory testing in 54 patients with severe- or critical-type 2019 novel coronavirus pneumonia	64
PI3K/Akt pathway-mediated HO-1 induction regulates mitochondrial quality control and attenuates endotoxin-induced acute lung injury	63
Deep learning assisted mitotic counting for breast cancer	61
Machine-based detection and classification for bone marrow aspirate differential counts: initial development focusing on nonneoplastic cells	60
Grading of adult diffuse gliomas according to the 2021 WHO Classification of Tumors of the Central Nervous System	54
STING expression in monocyte-derived macrophages is associated with the progression of liver inflammation and fibrosis in patients with nonalcoholic fatty liver disease	53
Adipose mesenchymal stem cell-derived exosomes accelerate skin wound healing via the lncRNA H19/miR-19b/SOX9 axis	49
Quantitative assessment of PD-L1 as an analyte in immunohistochemistry diagnostic assays using a standardized cell line tissue microarray	48
RIP1/RIP3/MLKL mediates dopaminergic neuron necroptosis in a mouse model of Parkinson disease	46
Role of macrophage TRPV4 in inflammation	46
Multiplexed ion beam imaging (MIBI) for characterization of the tumor microenvironment across tumor types	41
Quantitative measurement of HER2 expression to subclassify ERBB2 unamplified breast cancer	40
CCL3–CCR5 axis contributes to progression of esophageal squamous cell carcinoma by promoting cell migration and invasion via Akt and ERK pathways	40
N-methyladenosine reader YTHDF2-mediated long noncoding RNA FENDRR degradation promotes cell proliferation in endometrioid endometrial carcinoma	39
The TRPV4-AKT axis promotes oral squamous cell carcinoma cell proliferation via CaMKII activation	34
Deep-learning-based accurate hepatic steatosis quantification for histological assessment of liver biopsies	32
High-throughput proteomics: a methodological mini-review	32
Vascular remodeling by placenta-derived mesenchymal stem cells restores ovarian function in ovariectomized rat model via the VEGF pathway	32
Cas9-based enrichment and single-molecule sequencing for precise characterization of genomic duplications	31
Automated computerized image analysis for the user-independent evaluation of disease severity in preclinical models of NAFLD/NASH	31

The Shh/Gli signaling cascade regulates myofibroblastic activation of lung-resident mesenchymal stem cells via the modulation of Wnt10a expression during pulmonary fibrogenesis	31
miR-27a ameliorates chemoresistance of breast cancer cells by disruption of reactive oxygen species homeostasis and impairment of autophagy	30
Advancements in detection of SARS-CoV-2 infection for confronting COVID-19 pandemics	29
A new role for host annexin A2 in establishing bacterial adhesion to vascular endothelial cells: lines of evidence from atomic force microscopy and an in vivo study	29
Brightfield multiplex immunohistochemistry with multispectral imaging	28
Establishing a living biobank of patient-derived organoids of intraductal papillary mucinous neoplasms of the pancreas	28
Thy-1 depletion and integrin β3 upregulation-mediated PI3K-Akt-mTOR pathway activation inhibits lung fibroblast autophagy in lipopolysaccharide-induced pulmonary fibrosis	28
Wolfram syndrome 1 gene regulates pathways maintaining beta-cell health and survival	28
Deep learning shows the capability of high-level computer-aided diagnosis in malignant lymphoma	27
Hemoglobin oxidation generates globin-derived peptides in atherosclerotic lesions and intraventricular hemorrhage of the brain, provoking endothelial dysfunction	27
PAI-1 derived from cancer-associated fibroblasts in esophageal squamous cell carcinoma promotes the invasion of cancer cells and the migration of macrophages	27
Mitochondrial dysfunction/NLRP3 inflammasome axis contributes to angiotensin II-induced skeletal muscle wasting via PPAR-γ	27
3′ MACE RNA-sequencing allows for transcriptome profiling in human tissue samples after long-term storage	26
Blockade of intercellular adhesion molecule-1 prevents angiotensin II-induced hypertension and vascular dysfunction	26
Polydatin protects against lipopolysaccharide-induced endothelial barrier disruption via SIRT3 activation	26
Fibronectin 1 activates WNT/β-catenin signaling to induce osteogenic differentiation via integrin β1 interaction	26
The TRPV2 cation channels: from urothelial cancer invasiveness to glioblastoma multiforme interactome signature	26
Exosomes derived from hypoxic glioma deliver miR-1246 and miR-10b-5p to normoxic glioma cells to promote migration and invasion	25
Exosomal tau with seeding activity is released from Alzheimer's disease synapses, and seeding potential is associated with amyloid beta	25
The lncRNA XIST/miR-150-5p/c-Fos axis regulates sepsis-induced myocardial injury via TXNIP-modulated pyroptosis	25
The NanoSuit method: a novel histological approach for examining paraffin sections in a nondestructive manner by correlative light and electron microscopy	24
Predictive modeling of estrogen receptor agonism, antagonism, and binding activities using machine- and deep-learning approaches	24
Mouse pancreatic ductal organoid culture as a relevant model to study exocrine pancreatic ion secretion	24
Inhibiting the Notch signaling pathway suppresses Th17-associated airway hyperresponsiveness in obese asthmatic mice	24
TGFβ1-Smad canonical and -Erk noncanonical pathways participate in interleukin-17-induced epithelial–mesenchymal transition in Sjögren's syndrome	23
Transient receptor potential cation channel subfamily V and breast cancer	23
Ascl1-induced Wnt11 regulates neuroendocrine differentiation, cell proliferation, and E-cadherin expression in small-cell lung cancer and Wnt11 regulates small-cell lung cancer biology	23
SPOCK1 overexpression induced by platelet-derived growth factor-BB promotes hepatic stellate cell activation and liver fibrosis through the integrin α5β1/PI3K/Akt signaling pathway	23
Adipophilin expression in cutaneous malignant melanoma is associated with high proliferation and poor clinical prognosis	23
JAK2/STAT1-mediated HMGB1 translocation increases inflammation and cell death in a ventilator-induced lung injury model	23
Kras mutation rate precisely orchestrates ductal derived pancreatic intraepithelial neoplasia and pancreatic cancer	22
Enhanced alcoholic liver disease in mice with intestine-specific farnesoid X receptor deficiency	22
Exercise suppresses NLRP3 inflammasome activation in mice with diet-induced NASH: a plausible role of adropin	22
Digital quantitative assessment of PD-L1 using digital spatial profiling	22
Cannabinoid receptor 1 knockout alleviates hepatic steatosis by downregulating perilipin 2	22
Pseudomonas aeruginosa virulence proteins pseudolysin and protease IV impede cutaneous wound healing	22
ECM1 secreted by HER2-overexpressing breast cancer cells promotes formation of a vascular niche accelerating cancer cell migration and invasion	21
CircPAN3 ameliorates myocardial ischaemia/reperfusion injury by targeting miR-421/Pink1 axis-mediated autophagy suppression	21
Large-scale, three-dimensional tissue cytometry of the human kidney: a complete and accessible pipeline	21
NSG mice as hosts for oncological precision medicine	21
Ang-(1-7) treatment attenuates lipopolysaccharide-induced early pulmonary fibrosis	21
Nicotinamide riboside, an NAD+ precursor, attenuates inflammation and oxidative stress by activating sirtuin 1 in alcohol-stimulated macrophages	21
Th17/IL-17 induces endothelial cell senescence via activation of NF-κB/p53/Rb signaling pathway	21
Myocardial tissue-specific Dnmt1 knockout in rats protects against pathological injury induced by Adriamycin	20
CD38 in cancer-associated fibroblasts promotes pro-tumoral activity	20
Human urine-derived stem cell-derived exosomal miR-21-5p promotes neurogenesis to attenuate Rett syndrome via the EPha4/TEK axis	20
Curcumin attenuates Adriamycin-resistance of acute myeloid leukemia by inhibiting the lncRNA HOTAIR/miR-20a-5p/WT1 axis	20
LncRNA GAS5 activates the HIF1A/VEGF pathway by binding to TAF15 to promote wound healing in diabetic foot ulcers	20
Quantitative assessment of inflammatory infiltrates in kidney transplant biopsies using multiplex tyramide signal amplification and deep learning	20
Identification of differentially expressed genes in lung adenocarcinoma cells using single-cell RNA sequencing not detected using traditional RNA sequencing and microarray	20

TRPV4 activation by thermal and mechanical stimuli in disease progression	20
Mechanical strain induces phenotypic changes in breast cancer cells and promotes immunosuppression in the tumor microenvironment	20
Inhibition of microRNA-21-5p reduces keloid fibroblast autophagy and migration by targeting PTEN after electron beam irradiation	20
CircRNA-ST6GALNAC6 increases the sensitivity of bladder cancer cells to erastin-induced ferroptosis by regulating the HSPB1/P38 axis	19
Molecular signatures of tumor progression in myxoid liposarcoma identified by N-glycan mass spectrometry imaging	19
Urinary ERdj3 and mesencephalic astrocyte-derived neutrophic factor identify endoplasmic reticulum stress in glomerular disease	19
S100A4/non-muscle myosin II signaling regulates epithelial-mesenchymal transition and stemness in uterine carcinosarcoma	19
SOX2 has dual functions as a regulator in the progression of neuroendocrine prostate cancer	19
MicroRNA-182 improves spinal cord injury in mice by modulating apoptosis and the inflammatory response via IKKβ/NF-κB	19
Matrix metalloproteinase 11 (MMP11) in macrophages promotes the migration of HER2-positive breast cancer cells and monocyte recruitment through CCL2–CCR2 signaling	19
Digital image analysis of multiplex fluorescence IHC in colorectal cancer recognizes the prognostic value of CDX2 and its negative correlation with SOX2	19
Temperature elevation in epileptogenic foci exacerbates epileptic discharge through TRPV4 activation	19
Angiotensin-converting enzyme 2 influences pancreatic and renal function in diabetic mice	18
The HNRNPA2B1–MST1R–Akt axis contributes to epithelial-to-mesenchymal transition in head and neck cancer	18
Characterization of pathological thyroid tissue using polarization-sensitive second harmonic generation microscopy	18
Characterization of COVID-19-associated cardiac injury: evidence for a multifactorial disease in an autopsy cohort	18
MiR-185-5p ameliorates endoplasmic reticulum stress and renal fibrosis by downregulation of ATF6	18
Extracellular cold-inducible RNA-binding protein regulates neutrophil extracellular trap formation and tissue damage in acute pancreatitis	18
Zyxin (ZYX) promotes invasion and acts as a biomarker for aggressive phenotypes of human glioblastoma multiforme	18
Promotion of β-catenin/Foxo1 signaling ameliorates renal interstitial fibrosis	18
Blocking thrombospondin-1 signaling via CD47 mitigates renal interstitial fibrosis	18
Deep learning-based grading of ductal carcinoma in situ in breast histopathology images	18
LncRNA SLCO4A1-AS1 modulates colon cancer stem cell properties by binding to miR-150-3p and positively regulating SLCO4A1	18
Vascular endothelial growth factor enhances profibrotic activities through modulation of calcium homeostasis in human atrial fibroblasts	17
Biliary damage and liver fibrosis are ameliorated in a novel mouse model lacking l-histidine decarboxylase/histamine signaling	17
MiR-221-3p targets Hif-1α to inhibit angiogenesis in heart failure	17
LncRNA MAPKAPK5_AS1 facilitates cell proliferation in hepatitis B virus -related hepatocellular carcinoma	17
LncRNA XIST shuttled by adipose tissue-derived mesenchymal stem cell-derived extracellular vesicles suppresses myocardial pyroptosis in atrial fibrillation by disrupting miR-214-3p-mediated Arl2 inhib	17
TRPV2 channel as a possible drug target for the treatment of heart failure	17
Search for novel STAT3-dependent genes reveals SERPINA3 as a new STAT3 target that regulates invasion of human melanoma cells	17
GestAltNet: aggregation and attention to improve deep learning of gestational age from placental whole-slide images	17
Maternal diet intervention before pregnancy primes offspring lipid metabolism in liver	17
Extracellular vesicles derived from M2 microglia reduce ischemic brain injury through microRNA-135a-5p/TXNIP/NLRP3 axis	16
Overexpression of pigment epithelium-derived factor in placenta-derived mesenchymal stem cells promotes mitochondrial biogenesis in retinal cells	16
M1 macrophage-derived exosomes transfer miR-222 to induce bone marrow mesenchymal stem cell apoptosis	16
PCTR1 ameliorates lipopolysaccharide-induced acute inflammation and multiple organ damage via regulation of linoleic acid metabolism by promoting FADS1/FASDS2/ELOV2 expression and reducing PLA2 expres	16
Inhibition of miR-181a-5p reduces astrocyte and microglia activation and oxidative stress by activating SIRT1 in immature rats with epilepsy	16
Extra-mitochondrial citrate synthase initiates calcium oscillation and suppresses age-dependent sperm dysfunction	15
The synthetic toxin biliatresone causes biliary atresia in mice	15
Steatosis, inflammasome upregulation, and fibrosis are attenuated in miR-155 deficient mice in a high fat-cholesterol-sugar diet-induced model of NASH	15
Role of prion protein glycosylation in replication of human prions by protein misfolding cyclic amplification	15
Crosstalk between progesterone receptor membrane component 1 and estrogen receptor α promotes breast cancer cell proliferation	15
TNFAIP2 expression induces epithelial-to-mesenchymal transition and confers platinum resistance in urothelial cancer cells	15
MicroRNA-130b functions as an oncogene and is a predictive marker of poor prognosis in lung adenocarcinoma	15
Impairment of corneal epithelial wound healing is association with increased neutrophil infiltration and reactive oxygen species activation in tenascin X-deficient mice	15
Sustained hedgehog signaling in medulloblastoma tumoroids is attributed to stromal astrocytes and astrocyte-derived extracellular matrix	15
TRPM7 mediates kidney injury, endothelial hyperpermeability and mortality during endotoxemia	15
Differential regulation of claudin-2 and claudin-15 expression in children and adults with malabsorptive disease	15
Altered glycosylation of glycodelin in endometrial carcinoma	15
Macrophage-derived neurotrophin-3 promotes heterotopic ossification in rats	15
The role of macrophage–fibroblast interaction in lipopolysaccharide-induced pulmonary fibrosis: an acceleration in lung fibroblast aerobic glycolysis	14
Bioglass promotes wound healing by inhibiting endothelial cell pyroptosis through regulation of the connexin 43/reactive oxygen species (ROS) signaling pathway	14
Development of a simple osteoarthritis model useful to predict in vitro the anti-hypertrophic action of drugs	14
A mouse model for peritoneal metastases of colorectal origin recapitulates patient heterogeneity	14
βCysteine 93 in human hemoglobin: a gateway to oxidative stability in health and disease	14
Feline low-grade intestinal T cell lymphoma: a unique natural model of human indolent T cell lymphoproliferative disorder of the gastrointestinal tract	14
Sporadic and Lynch syndrome-associated mismatch repair-deficient brain tumors	14
Lipid droplet velocity is a microenvironmental sensor of aggressive tumors regulated by V-ATPase and PEDF	13
Fatty acid beta oxidation enzyme HADHA is a novel potential therapeutic target in malignant lymphoma	13
Performance and efficiency of machine learning algorithms for analyzing rectangular biomedical data	13
SIRT6 regulates SREBP1c-induced glucolipid metabolism in liver and pancreas via the AMPKα-mTORC1 pathway	13
Reliability of liquid biopsy analysis: an inter-laboratory comparison of circulating tumor DNA extraction and sequencing with different platforms	13
Establishing standardized immune phenotyping of metastatic melanoma by digital pathology	13
Loss of ephrin B2 receptor (EPHB2) sets lipid rheostat by regulating proteins DGAT1 and ATGL inducing lipid droplet storage in prostate cancer cells	13
Immunomodulator polyinosinic-polycytidylic acid enhances the inhibitory effect of 13-cis-retinoic acid on neuroblastoma through a TLR3-related immunogenic-apoptotic response	13
NFAT5 promotes oral squamous cell carcinoma progression in a hyperosmotic environment	13
Accelerated instability testing reveals quantitative mass spectrometry overcomes specimen storage limitations associated with PD-L1 immunohistochemistry	13
A novel image signature-based radiomics method to achieve precise diagnosis and prognostic stratification of gliomas	13
Antifibrotic effects of hypocalcemic vitamin D analogs in murine and human hepatic stellate cells and in the CCl4 mouse model	13
CircN4BP2L2 promotes colorectal cancer growth and metastasis through regulation of the miR-340-5p/CXCR4 axis	12
Adipose tissue inflammation and systemic insulin resistance in mice with diet-induced obesity is possibly associated with disruption of PFKFB3 in hematopoietic cells	12
Regulation of pancreatic cancer TRAIL resistance by protein O-GlcNAcylation	12
Impairment of autophagy in scrapie-infected transgenic mice at the clinical stage	12
Distinct macrophage polarization in acute and chronic gout	12
ETS2 promotes epithelial-to-mesenchymal transition in renal fibrosis by targeting JUNB transcription	12
MiR-126-5p promotes contractile switching of aortic smooth muscle cells by targeting VEPH1 and alleviates Ang II-induced abdominal aortic aneurysm in mice	12
SMAD4 mutation correlates with poor prognosis in non-small cell lung cancer	12
Cholestasis impairs hepatic lipid storage via AMPK and CREB signaling in hepatitis B virus surface protein transgenic mice	12
Ubiquitin-specific protease 35 (USP35) mediates cisplatin-induced apoptosis by stabilizing BIRC3 in non-small cell lung cancer	12
IL-37bΔ1-45 suppresses the migration and invasion of endometrial cancer cells by targeting the Rac1/NF-κB/MMP2 signal pathway	12

miR-184 targets TP63 to block idiopathic pulmonary fibrosis by inhibiting proliferation and epithelial–mesenchymal transition of airway epithelial cells	12
Hepatocyte-specific fibroblast growth factor 21 overexpression ameliorates high-fat diet-induced obesity and liver steatosis in mice	11
Isoform-specific promotion of breast cancer tumorigenicity by TBX3 involves induction of angiogenesis	11
Reproducible, high-dimensional imaging in archival human tissue by multiplexed ion beam imaging by time-of-flight (MIBI-TOF)	11
Muc5ac null mice are predisposed to spontaneous gastric antro-pyloric hyperplasia and adenomas coupled with attenuated H.pylori-induced corpus mucous metaplasia	11
Exploring photoacoustic spectroscopy-based machine learning together with metabolomics to assess breast tumor progression in a xenograft model ex vivo	11
Alternative activation of macrophages by prostacyclin synthase ameliorates alcohol induced liver injury	11
DNA methyltransferase 1 (DNMT1) suppresses mitophagy and aggravates heart failure via the microRNA-152-3p/ETS1/RhoH axis	11
A simplified integrated molecular and immunohistochemistry-based algorithm allows high accuracy prediction of glioblastoma transcriptional subtypes	11
EZH2 is associated with cartilage degeneration in osteoarthritis by promoting SDC1 expression via histone methylation of the microRNA-138 promoter	11
FABP4 activates the JAK2/STAT2 pathway via Rap1a in the homocysteine-induced macrophage inflammatory response in ApoE mice atherosclerosis	11
TRPC5 regulates axonal outgrowth in developing retinal ganglion cells	11
Sox13 promotes hepatocellular carcinoma metastasis by transcriptionally activating Twist1	11
RAMP1 signaling in immune cells regulates inflammation-associated lymphangiogenesis	11
PLODs are overexpressed in ovarian cancer and are associated with gap junctions via connexin 43	11
Long noncoding Mirt2 reduces apoptosis to alleviate myocardial infarction through regulation of the miR-764/PDK1 axis	11
SECISBP2 is a novel prognostic predictor that regulates selenoproteins in diffuse large B-cell lymphoma	11
Phospholipase Cγ1 (PLCG1) overexpression is associated with tumor growth and poor survival in IDH wild-type lower-grade gliomas in adult patients	10
6-Gingerol relieves myocardial ischaemia/reperfusion injury by regulating lncRNA H19/miR-143/ATG7 signaling axis-mediated autophagy	10
MicroRNA-432-5p regulates sprouting and intussusceptive angiogenesis in osteosarcoma microenvironment by targeting PDGFB	10
Distinct transcriptional programs of SOX2 in different types of small cell lung cancers	10
Monomeric C reactive protein (mCRP) regulates inflammatory responses in human and mouse chondrocytes	10
The transient receptor potential vanilloid 4 (TRPV4) ion channel mediates protease activated receptor 1 (PAR1)-induced vascular hyperpermeability	10
Early response in phosphorylation of ribosomal protein S6 is associated with sensitivity to trametinib in colorectal cancer cells	10
Generation of heterozygous PKD1 mutant pigs exhibiting early-onset renal cyst formation	10
The antioxidative stress regulator Nrf2 potentiates radioresistance of oral squamous cell carcinoma accompanied with metabolic modulation	10
The high-density lipoprotein receptor Scarb1 is required for normal bone differentiation in vivo and in vitro	10
Generation of a new immortalized human lung pericyte cell line: a promising tool for human lung pericyte studies	10
Production of TRPV2-targeting functional antibody ameliorating dilated cardiomyopathy and muscular dystrophy in animal models	10
LncRNA UCC promotes epithelial–mesenchymal transition via the miR-143-3p/SOX5 axis in non-small-cell lung cancer	10
Hepatitis B virus core protein promotes the expression of neuraminidase 1 to facilitate hepatocarcinogenesis	10
Selective Ah receptor modulators attenuate NPC1L1-mediated cholesterol uptake through repression of SREBP-2 transcriptional activity	10
LncRNA SNHG5 upregulation induced by YY1 contributes to angiogenesis via miR-26b/CTGF/VEGFA axis in acute myelogenous leukemia	10
Blockade of MDM2 with inactive Cas9 prevents epithelial to mesenchymal transition in retinal pigment epithelial cells	10
Prostaglandin E2 receptor EP1 (PGE2/EP1) deletion promotes glomerular podocyte and endothelial cell injury in hypertensive TTRhRen mice	10
Long non-coding RNA MALAT1 enhances angiogenesis during bone regeneration by regulating the miR-494/SP1 axis	10
Pretreatment with valproic acid alleviates pulmonary fibrosis through epithelial–mesenchymal transition inhibition in vitro and in vivo	10
GTSE1 promotes prostate cancer cell proliferation via the SP1/FOXM1 signaling pathway	10
LncRNA SNHG15 relieves hyperglycemia-induced endothelial dysfunction via increased ubiquitination of thioredoxin-interacting protein	10
Circulating tumor DNA profiling for childhood brain tumors: Technical challenges and evidence for utility	10
A new technological approach in diagnostic pathology: mass spectrometry imaging-based metabolomics for biomarker detection in urachal cancer	10