Laboratory Investigation

Article	Citations
Inside the USCAP Journals	296
Abstracts from USCAP 2021: Gynecologic And Obstetric Pathology (532-634)	132
LncRNA SNHG5 upregulation induced by YY1 contributes to angiogenesis via miR-26b/CTGF/VEGFA axis in acute myelogenous leukemia	91
Erratum to “Switch/Sucrose Nonfermentable-Deficient Tumors—Morphology, Immunophenotype, Genetics, Epigenetics, Nosology, and Therapy” [Laboratory Investigation 105(2025) 102185]	83
Automated scoring to assess RAD51-mediated homologous recombination in ovarian patient-derived tumor organoids	61
Exosomal tau with seeding activity is released from Alzheimer's disease synapses, and seeding potential is associated with amyloid beta	46
Inside the USCAP Journals	44
Integrated Cytometry With Machine Learning Applied to High-Content Imaging of Human Kidney Tissue for In Situ Cell Classification and Neighborhood Analysis	44
Inside the USCAP Journals	41
USCAP 2022 Abstracts: Medical Renal Pathology (including renal transplantation) (1076-1088)	40
NEUROPATHOLOGY AND OPHTHALMIC PATHOLOGY	38
USCAP 2022 Abstracts: Education (341-355)	37
USCAP 2022 Abstracts: Bone and Soft Tissue Pathology (24-73)	36
GYNECOLOGIC AND OBSTETRIC PATHOLOGY	35
CYTOPATHOLOGY	35
EDUCATION	34
CARDIOVASCULAR PATHOLOGY	34
Editorial Board	34
EDUCATION	32
LIVER PATHOLOGY	32
PATHOBIOLOGY AND EMERGING TECHNIQUES	32
INFECTIOUS DISEASE PATHOLOGY	32
CAREER DEVELOPMENT	32
Abstracts from USCAP 2021: Breast Pathology (66-147)	31
Abstracts from USCAP 2021: Dermatopathology (238-270)	29

Abstracts from USCAP 2021: Education (271-295)	29
Activation of RSK2 upregulates SOX8 to promote methotrexate resistance in gestational trophoblastic neoplasia	28
Abstracts from USCAP 2021: Quality and Patient Safety (953-989)	28
USCAP 2022 Abstracts: Autopsy and Forensics (1-23)	28
Prognostic Effect of Tertiary Lymphoid Structures in Epstein–Barr Virus–Associated Gastric Carcinomas Measured by Digital Image Analysis	27
Spatial Proximity and Relative Distribution of Tumor-Infiltrating Lymphocytes and Macrophages Predict Survival in Melanoma	26
Bioglass promotes wound healing by inhibiting endothelial cell pyroptosis through regulation of the connexin 43/reactive oxygen species (ROS) signaling pathway	26
A time-course Raman spectroscopic analysis of spontaneous in vitro microcalcifications in a breast cancer cell line	25
Bone morphogenetic protein induces bone invasion of melanoma by epithelial–mesenchymal transition via the Smad1/5 signaling pathway	25
Forkhead box F1 induces columnar phenotype and epithelial-to-mesenchymal transition in esophageal squamous cells to initiate Barrett's like metaplasia	25
Is Congenital Muscular Mitral-Aortic Discontinuity Another Feature of Obstructive Hypertrophic Cardiomyopathy? A Pathology Validation Study	24
Impact of P-selectin–PSGL-1 Axis on Platelet-Endothelium-Leukocyte Interactions in Fatal COVID-19	24
Evaluating and comparing immunostaining and computational methods for spatial profiling of drug response in patient-derived explants	24
Patient-derived xenografts and in vitro model show rationale for imatinib mesylate repurposing in HEY1-NCoA2-driven mesenchymal chondrosarcoma	23
Lengthening of 3′ Untranslated Regions of mRNAs by Alternative Polyadenylation Is Associated With Tumor Progression and Poor Prognosis of Clear Cell Renal Cell Carcinoma	23
Advanced detection strategies for cardiotropic virus infection in a cohort study of heart failure patients	23
Nuclear Localization of Yes-Associated Protein Is Associated With Tumor Progression in Cutaneous Melanoma	23
Acidosis induces synovial fibroblasts to release vascular endothelial growth factor via acid-sensitive ion channel 1a	22
Epigenetic Alteration of H3K27me3 as a Possible Oncogenic Mechanism of Central Neurocytoma	22
Addressing Modern Diagnostic Pathology for Patient-Derived Soft Tissue Sarcosphere Models in the Era of Functional Precision Oncology	22
Letter to the Editor (Correspondence): Re: genetic loss-of-function of activating transcription factor 3 but not C-type lectin member 5A prevents diabetic peripheral neuropathy	21
Inside the USCAP Journals	21
SECISBP2 is a novel prognostic predictor that regulates selenoproteins in diffuse large B-cell lymphoma	21
Generation of heterozygous PKD1 mutant pigs exhibiting early-onset renal cyst formation	20
Digital Hepatic Iron Content: An Artificial Intelligence Model for Spatially Resolved Histologic Iron Quantitative Analysis in Liver Samples	20
Panoramic Tissue Examination That Integrates 3-Dimensional Pathology Imaging and Gene Mutation: Potential Utility in Non–Small Cell Lung Cancer	20
HEAD AND NECK PATHOLOGY	19
Pathophysiologic Implications and Therapeutic Approach of Klotho in Chronic Kidney Disease: A Systematic Review	19
The diagnostic utility of DNA copy number analysis of core needle biopsies from soft tissue and bone tumors	19
Long transcripts minus touchdown qPCR (LTMT-qPCR): a simplified and convenient method for the screening and quantification of microRNA profile	18
Structural Elucidation and Prognostic Relevance of 297-11A-Sulfated Glycans in Ovarian Carcinoma	18
A Transgenic Pig Model With Human Mutant SOD1 Exhibits the Early Pathology of Amyotrophic Lateral Sclerosis	18
Sporadic and Lynch syndrome-associated mismatch repair-deficient brain tumors	18
Primary Cilia Are Frequently Present in Small Cell Lung Carcinomas but Not in Non–Small Cell Lung Carcinomas or Lung Carcinoids	18
Urokinase Plasminogen Activator Deficiency Aggravates Cationic Bovine Serum Albumin–Induced Membranous Nephropathy Through T Helper Cell Type 2-Prone Immune Response in Mice	18
Modulation of osteoclastogenesis through adrenomedullin receptors on osteoclast precursors: initiation of differentiation by asymmetric cell division	18
Consistency Analysis of Programmed Death Ligand 1 Expression in Non–Small Cell Lung Cancer Between Pleural Effusion and Matched Primary Lung Cancer Tissues by Immunohistochemical Double Staining	18
Analysis of DNA variants in miRNAs and miRNA 3ʼUTR binding sites in female infertility patients	17
Patterns of Unwanted Biological and Technical Expression Variation Among 49 Human Tissues	17
Gratitude and a Warning	17
Quantitative analysis of abnormalities in gynecologic cytopathology with deep learning	16
5-HT7 receptor-dependent intestinal neurite outgrowth contributes to visceral hypersensitivity in irritable bowel syndrome	16
RNA adenosine deaminase (ADAR1) alleviates high-fat diet-induced nonalcoholic fatty liver disease by inhibiting NLRP3 inflammasome	16
Fibroblast Growth Factor Receptors and Ligands in Context of Bevacizumab Response in Ovarian Carcinoma: An Exploratory Analysis of AGO-OVAR11/ICON-7	16
Development of a Pathomics-Based Model for the Prediction of Malignant Transformation in Oral Leukoplakia	16
PLOD3 regulates the expression of YAP1 to affect the progression of non-small cell lung cancer via the PKCδ/CDK1/LIMD1 signaling pathway	16
NLRP3 deficiency did not attenuate NASH development under high fat calorie diet plus high fructose and glucose in drinking water	16
Evaluation of A Computer-Aided Detection Software for Prostate Cancer Prediction: Excellent Diagnostic Accuracy Independent of Preanalytical Factors	16
The antioxidative stress regulator Nrf2 potentiates radioresistance of oral squamous cell carcinoma accompanied with metabolic modulation	16
A generative adversarial approach to facilitate archival-quality histopathologic diagnoses from frozen tissue sections	16

Advanced oxidation protein products downregulate CYP1A2 and CYP3A4 expression and activity via the NF-κB-mediated signaling pathway in vitro and in vivo	15
Exploring photoacoustic spectroscopy-based machine learning together with metabolomics to assess breast tumor progression in a xenograft model ex vivo	15
Cigarette Smoke Enhances the Malignant Phenotype of Esophageal Adenocarcinoma Cells by Disrupting a Repressive Regulatory Interaction Between miR-145 and LOXL2	15
Metabolomic and Transcriptomic Correlative Analyses in Germ-Free Mice Link Lacticaseibacillus rhamnosus GG-Associated Metabolites to Host Intestinal Fatty Acid Metabolism and β-Oxidation	15
The lncRNA XIST/miR-150-5p/c-Fos axis regulates sepsis-induced myocardial injury via TXNIP-modulated pyroptosis	15
Quantitative assessment of Siglec-15 expression in lung, breast, head, and neck squamous cell carcinoma and bladder cancer	15
ATF-3 expression inhibits melanoma growth by downregulating ERK and AKT pathways	14
A diet-induced murine model for non-alcoholic fatty liver disease with obesity and insulin resistance that rapidly develops steatohepatitis and fibrosis	14
Brusatol sensitizes endometrial hyperplasia and cancer to progestin by suppressing NRF2-TET1-AKR1C1-mediated progestin metabolism	14
Long noncoding Mirt2 reduces apoptosis to alleviate myocardial infarction through regulation of the miR-764/PDK1 axis	14
SIRT6 regulates SREBP1c-induced glucolipid metabolism in liver and pancreas via the AMPKα-mTORC1 pathway	14
The Notch signalling pathway and miRNA regulation play important roles in the differentiation of Schwann cells from adipose-derived stem cells	14
Quantitative Nuclear Grading: An Objective, Artificial Intelligence–Facilitated Foundation for Grading Noninvasive Papillary Urothelial Carcinoma	13
Engineered Knockout of TRPA1 Inhibits Laser-Induced Choroidal Neovascularization Along With Associated TGFβ1 Expression and Neutrophil Infiltration	13
COLEC10 Induces Endoplasmic Reticulum Stress by Occupying GRP78 and Inhibits Hepatocellular Carcinoma	13
Phospholipase Cγ1 (PLCG1) overexpression is associated with tumor growth and poor survival in IDH wild-type lower-grade gliomas in adult patients	13
Role of Stromal Fibroblast–Induced WNT7A Associated with Cancer Cell Migration Through the AKT/CLDN1 Signaling Axis in Oral Squamous Cell Carcinoma	13
Cell-free plasma microRNAs that identify patients with glioblastoma	13
Utility of Machine Learning to Detect Cytomegalovirus in Digital Hematoxylin and Eosin–Stained Slides	13
Sex-specific Stone-forming Phenotype in Mice During Hypercalciuria/Urine Alkalinization	13
Interactions between leucines within the signal peptides of megalin and stanniocalcin-1 are crucial for regulation of mitochondrial metabolism	12
Spatial Heterogeneity of PD-1/PD-L1 Defined Osteosarcoma Microenvironments at Single-Cell Spatial Resolution	12
Immunoproteomics Reveal Different Characteristics for the Prognostic Markers of Intratumoral-Infiltrating CD3+ T Lymphocytes and Immunoscore in Colorectal Cancer	12
Early Diagnostic Markers for Esophageal Squamous Cell Carcinoma: Copy Number Alteration Gene Identification and cfDNA Detection	12
STAT3 regulates SRGN and promotes metastasis of nasopharyngeal carcinoma through the FoxO1-miR-148a-5p-CREB1 axis	12
Implementation of Digital Pathology and Artificial Intelligence in Routine Pathology Practice	12
Conventional histological and cytological staining with simultaneous immunohistochemistry enabled by invisible chromogens	12
Oncogenic Role of the NFATC2/NEDD4/FBP1 Axis in Cholangiocarcinoma	12
Elevated Cancer-Associated Hyaluronan Correlates With Diagnosis and Lymph Node Metastasis of Papillary Thyroid Cancer	12
Expression of Forkhead Box M1 and Anticancer Effects of FOXM1 Inhibition in Epithelioid Sarcoma	12
Overexpression of COX7A1 Promotes the Resistance of Gastric Cancer to Oxaliplatin and Weakens the Efficacy of Immunotherapy	12
Spatial Transcriptomics Reveal Pitfalls and Opportunities for the Detection of Rare High-Plasticity Breast Cancer Subtypes	12
Revolutionizing Digital Pathology With the Power of Generative Artificial Intelligence and Foundation Models	12
Omic Studies on In Vitro Cystinosis Model: siRNA-Mediated CTNS Gene Silencing in HK-2 Cells	12
Machine Vision–Detected Peritumoral Lymphocytic Aggregates Are Associated With Disease-Free Survival in Patients With Papillary Thyroid Carcinoma	12
Peptidomics and Machine Learning–based Evaluation of Noncoding RNA–Derived Micropeptides in Breast Cancer: Expression Patterns and Functional/Therapeutic Insights	12
Establishing and Characterizing the Molecular Profiles, Cellular Features, and Clinical Utility of a Patient-Derived Xenograft Model Using Benign Prostatic Tissues	12
Fibroblast growth factor 21, a stress regulator, inhibits Drp1 activation to alleviate skeletal muscle ischemia/reperfusion injury	12
FABP4 activates the JAK2/STAT2 pathway via Rap1a in the homocysteine-induced macrophage inflammatory response in ApoE mice atherosclerosis	12
Alternative activation of macrophages by prostacyclin synthase ameliorates alcohol induced liver injury	11
MicroRNA-182 improves spinal cord injury in mice by modulating apoptosis and the inflammatory response via IKKβ/NF-κB	11
Characterization of COVID-19-associated cardiac injury: evidence for a multifactorial disease in an autopsy cohort	11
Targeted Quantitative Mass Spectrometry Analysis of Protein Biomarkers From Previously Stained Single Formalin-Fixed Paraffin-Embedded Tissue Sections	11
Serotonin-induced vascular permeability is mediated by transient receptor potential vanilloid 4 in the airways and upper gastrointestinal tract of mice	11
Recombinant myelin oligodendrocyte glycoprotein quality modifies evolution of experimental autoimmune encephalitis in macaques	11
SIRT1: An Intermediator of Key Pathways Regulating Pulmonary Diseases	11
Corrigendum to “Advanced oxidation protein products promote NADPH oxidase–dependent β-cell destruction and dysfunction by a Bcl-2/Bax apoptotic pathway”	11
Correction to: Hyperglycemia promotes myocardial dysfunction via the ERS-MAPK10 signaling pathway in db/db mice	11
Alveolar Mitochondrial Quality Control During Acute Respiratory Distress Syndrome	11
Idelalisib inhibits experimental proliferative vitroretinopathy	11
Associations of Single Versus Multiple Human Papillomavirus Infections With the Prevalence of Cervical Intraepithelial Neoplasia 2/3 and Squamous Cell Carcinoma Lesions: Human Papillomavirus Type–Spec	11
Melatonin Alleviates Acute Respiratory Distress Syndrome by Inhibiting Alveolar Macrophage NLRP3 Inflammasomes Through the ROS/HIF-1α/GLUT1 Pathway	11
Fluvastatin sensitizes pancreatic cancer cells toward radiation therapy and suppresses radiation- and/or TGF-β-induced tumor-associated fibrosis	10
Dysregulated Activation of Hippo-YAP1 Signaling Induces Oxidative Stress and Aberrant Development of Intrahepatic Biliary Cells in Biliary Atresia	10
A new technological approach in diagnostic pathology: mass spectrometry imaging-based metabolomics for biomarker detection in urachal cancer	10
Indoxyl Sulfate Promotes Metastatic Characteristics of Ovarian Cancer Cells via Aryl Hydrocarbon Receptor–Mediated Downregulation of the Mas Receptor	10
CP-25 alleviates antigen-induced experimental Sjögren's syndrome in mice by inhibiting JAK1-STAT1/2-CXCL13 signaling and interfering with B-cell migration	10
Diagnostic Utility of Next-Generation Sequencing in Circulating Free DNA and a Comparison With Matched Tissue in Gallbladder Carcinoma	10
An Innovative and Accurate Next-Generation Sequencing–Based Microsatellite Instability Detection Method for Colorectal and Endometrial Tumors	10
Spatiotemporal Cellular Dynamics of Germinal Center Reaction in Coronavirus Disease 2019 Lung-Draining Lymph Node Based on Imaging-Based Spatial Transcriptomics	10
Spatial Lipidomics Reveals Myelin Defects and Protumor Macrophage Infiltration in Malignant Peripheral Nerve Sheath Tumor Adjacent Nerves	10
LncRNA SLCO4A1-AS1 modulates colon cancer stem cell properties by binding to miR-150-3p and positively regulating SLCO4A1	10
Development of an immunohistochemical assay for Siglec-15	10
Inside the USCAP Journals	10
Genomic Landscape of Superficial Malignant Peripheral Nerve Sheath Tumor	10
Molecular and Immunohistochemical Classification of Extrapulmonary Small Cell Neuroendocrine Carcinomas: A Study of 181 Cases	10
The Struggle Continues: NPC-TW01, A Misidentified Cell Line	10
Targeting SIRT4/TET2 Signaling Alleviates Human Keratinocyte Senescence by Reducing 5-hydroxymethylcytosine Loss	10
Using Artificial Intelligence to Identify Tumor Microenvironment Heterogeneity in Non–Small Cell Lung Cancers	10
A novel human endometrial epithelial cell line for modeling gynecological diseases and for drug screening	10
Inside the USCAP journals	10
Tumor Necrosis Factor-α–Dependent Inflammation Upregulates High Mobility Group Box 1 To Induce Tumor Promotion and Anti–Programmed Cell Death Protein-1 Immunotherapy Resistance in Lung Adenocarcinoma	10
A Novel Mathematical Approach for Analysis of Integrated Cell–Patient Data Uncovers a 6-Gene Signature Linked to Endocrine Therapy Resistance	9
A novel image signature-based radiomics method to achieve precise diagnosis and prognostic stratification of gliomas	9
Inside the USCAP journals	9
WISP-2 modulates the induction of inflammatory mediators and cartilage catabolism in chondrocytes	9
Overexpression of carnitine palmitoyltransferase 1A promotes mitochondrial fusion and differentiation of glioblastoma stem cells	9
The Detection of Neoplastic Cells Using Objective Cytomorphologic Parameters in Malignant Lymphoma	9
Feline low-grade intestinal T cell lymphoma: a unique natural model of human indolent T cell lymphoproliferative disorder of the gastrointestinal tract	9
Identification of RNF213 as a Potential Suppressor of Local Invasion in Intrahepatic Cholangiocarcinoma	9

Th17/IL-17 induces endothelial cell senescence via activation of NF-κB/p53/Rb signaling pathway	9
Enhanced phosphorylation of c-Jun by cisplatin treatment as a potential predictive biomarker for cisplatin response in combination with patient-derived tumor organoids	9
Comparing Accuracy of Helicobacter pylori Identification Using Traditional Hematoxylin and Eosin–Stained Glass Slides With Digital Whole Slide Imaging	9
Integrin β3 Mediates Sepsis and Mechanical Ventilation-Associated Pulmonary Fibrosis Through Glycometabolic Reprogramming	9
Phenotyping clonal populations of glioma stem cell reveals a high degree of plasticity in response to changes of microenvironment	9
A Pipeline for Evaluation of Machine Learning/Artificial Intelligence Models to Quantify Programmed Death Ligand 1 Immunohistochemistry	9
Increased chemosensitivity via BRCA2-independent DNA damage in DSS1- and PCID2-depleted breast carcinomas	9
Experimental models of undifferentiated pleomorphic sarcoma and malignant peripheral nerve sheath tumor	9
Expression Microdissection for the Analysis of miRNA in a Single-Cell Type	9
Selecting Preclinical Animal Models in Hepatology Research: A Call for Uniform Guidelines	8
p21-activated kinase 2 binds to transcription factor SOX2 and up-regulates DEK to promote the progression of lung squamous cell carcinoma	8
Nup210 Promotes Colorectal Cancer Progression by Regulating Nuclear Plasma Transport	8
Involvement of BRD4 in Alcoholic Liver Injury: Autophagy Modulation via Regulation of the SIRT1/Beclin1 Axis	8
Distinguishing Gastric/Esophageal Adenocarcinoma from Pancreatic Adenocarcinoma Using Methylation-Based Droplet Digital PCR	8
A murine mesenchymal stem cell model for initiating events in osteosarcomagenesis points to CDK4/CDK6 inhibition as a therapeutic target	8
Alteration of HER2 Status During Breast Cancer Progression: A Clinicopathological Analysis Focusing on HER2-Low Status	8
Effects of Degreasing Pretreatment on Immunohistochemistry and Molecular Analysis of Gastrointestinal and Breast Cancer Samples	8
Curcumin attenuates Adriamycin-resistance of acute myeloid leukemia by inhibiting the lncRNA HOTAIR/miR-20a-5p/WT1 axis	8
Concordance of Whole-Slide Imaging and Conventional Light Microscopy for Assessment of Pathologic Response Following Neoadjuvant Therapy for Lung Cancer	8
Ubiquitin-specific protease 3 facilitates cell proliferation by deubiquitinating pyruvate kinase L/R in gallbladder cancer	8
Correction to: M1 macrophage-derived exosomes transfer miR-222 to induce bone marrow mesenchymal stem cell apoptosis	8
Synthetic Data and Its Utility in Pathology and Laboratory Medicine	8
Junctional Epidermolysis Bullosa in Sprague Dawley Rats Caused by a Frameshift Mutation of Col17a1 Gene	8