Laboratory Investigation

Article	Citations
Artificial intelligence and computational pathology	279
High-throughput proteomics: a methodological mini-review	114
Grading of adult diffuse gliomas according to the 2021 WHO Classification of Tumors of the Central Nervous System	83
Adipose mesenchymal stem cell-derived exosomes accelerate skin wound healing via the lncRNA H19/miR-19b/SOX9 axis	75
Detection of SARS-CoV-2 in formalin-fixed paraffin-embedded tissue sections using commercially available reagents	75
Quantitative measurement of HER2 expression to subclassify ERBB2 unamplified breast cancer	61
N-methyladenosine reader YTHDF2-mediated long noncoding RNA FENDRR degradation promotes cell proliferation in endometrioid endometrial carcinoma	46
Vascular remodeling by placenta-derived mesenchymal stem cells restores ovarian function in ovariectomized rat model via the VEGF pathway	44
PAI-1 derived from cancer-associated fibroblasts in esophageal squamous cell carcinoma promotes the invasion of cancer cells and the migration of macrophages	40
Advancements in detection of SARS-CoV-2 infection for confronting COVID-19 pandemics	40
Exosomal tau with seeding activity is released from Alzheimer's disease synapses, and seeding potential is associated with amyloid beta	37
CircRNA-ST6GALNAC6 increases the sensitivity of bladder cancer cells to erastin-induced ferroptosis by regulating the HSPB1/P38 axis	37
MicroRNA-182 improves spinal cord injury in mice by modulating apoptosis and the inflammatory response via IKKβ/NF-κB	36
Th17/IL-17 induces endothelial cell senescence via activation of NF-κB/p53/Rb signaling pathway	36
Fibronectin 1 activates WNT/β-catenin signaling to induce osteogenic differentiation via integrin β1 interaction	34
Exosomes derived from hypoxic glioma deliver miR-1246 and miR-10b-5p to normoxic glioma cells to promote migration and invasion	34
The lncRNA XIST/miR-150-5p/c-Fos axis regulates sepsis-induced myocardial injury via TXNIP-modulated pyroptosis	34
Predictive modeling of estrogen receptor agonism, antagonism, and binding activities using machine- and deep-learning approaches	34
Exercise suppresses NLRP3 inflammasome activation in mice with diet-induced NASH: a plausible role of adropin	32
Pseudomonas aeruginosa virulence proteins pseudolysin and protease IV impede cutaneous wound healing	32
Matrix metalloproteinase 11 (MMP11) in macrophages promotes the migration of HER2-positive breast cancer cells and monocyte recruitment through CCL2–CCR2 signaling	32
Establishing a living biobank of patient-derived organoids of intraductal papillary mucinous neoplasms of the pancreas	32
LncRNA GAS5 activates the HIF1A/VEGF pathway by binding to TAF15 to promote wound healing in diabetic foot ulcers	32
Nicotinamide riboside, an NAD+ precursor, attenuates inflammation and oxidative stress by activating sirtuin 1 in alcohol-stimulated macrophages	32
LncRNA XIST shuttled by adipose tissue-derived mesenchymal stem cell-derived extracellular vesicles suppresses myocardial pyroptosis in atrial fibrillation by disrupting miR-214-3p-mediated Arl2 inhib	31

Mechanical strain induces phenotypic changes in breast cancer cells and promotes immunosuppression in the tumor microenvironment	30
CircPAN3 ameliorates myocardial ischaemia/reperfusion injury by targeting miR-421/Pink1 axis-mediated autophagy suppression	30
Curcumin attenuates Adriamycin-resistance of acute myeloid leukemia by inhibiting the lncRNA HOTAIR/miR-20a-5p/WT1 axis	29
Human urine-derived stem cell-derived exosomal miR-21-5p promotes neurogenesis to attenuate Rett syndrome via the EPha4/TEK axis	29
Hepatocyte-specific fibroblast growth factor 21 overexpression ameliorates high-fat diet-induced obesity and liver steatosis in mice	29
Sporadic and Lynch syndrome-associated mismatch repair-deficient brain tumors	28
Quantitative assessment of inflammatory infiltrates in kidney transplant biopsies using multiplex tyramide signal amplification and deep learning	28
M1 macrophage-derived exosomes transfer miR-222 to induce bone marrow mesenchymal stem cell apoptosis	27
A convolutional neural network model for survival prediction based on prognosis-related cascaded Wx feature selection	26
Kras mutation rate precisely orchestrates ductal derived pancreatic intraepithelial neoplasia and pancreatic cancer	26
CD38 in cancer-associated fibroblasts promotes pro-tumoral activity	25
Deep learning-based grading of ductal carcinoma in situ in breast histopathology images	25
Distinct macrophage polarization in acute and chronic gout	25
MiR-221-3p targets Hif-1α to inhibit angiogenesis in heart failure	25
The role of macrophage–fibroblast interaction in lipopolysaccharide-induced pulmonary fibrosis: an acceleration in lung fibroblast aerobic glycolysis	25
Extracellular vesicles derived from M2 microglia reduce ischemic brain injury through microRNA-135a-5p/TXNIP/NLRP3 axis	24
Performance and efficiency of machine learning algorithms for analyzing rectangular biomedical data	24
LncRNA MAPKAPK5_AS1 facilitates cell proliferation in hepatitis B virus -related hepatocellular carcinoma	24
Characterization of COVID-19-associated cardiac injury: evidence for a multifactorial disease in an autopsy cohort	24
Reproducible, high-dimensional imaging in archival human tissue by multiplexed ion beam imaging by time-of-flight (MIBI-TOF)	23
FABP4 activates the JAK2/STAT2 pathway via Rap1a in the homocysteine-induced macrophage inflammatory response in ApoE mice atherosclerosis	23
The synthetic toxin biliatresone causes biliary atresia in mice	23
The HNRNPA2B1–MST1R–Akt axis contributes to epithelial-to-mesenchymal transition in head and neck cancer	23
GestAltNet: aggregation and attention to improve deep learning of gestational age from placental whole-slide images	23
LncRNA SLCO4A1-AS1 modulates colon cancer stem cell properties by binding to miR-150-3p and positively regulating SLCO4A1	23
Standardized Pathology Screening of Mature Tertiary Lymphoid Structures in Cancers	22
Bioglass promotes wound healing by inhibiting endothelial cell pyroptosis through regulation of the connexin 43/reactive oxygen species (ROS) signaling pathway	22
MiR-185-5p ameliorates endoplasmic reticulum stress and renal fibrosis by downregulation of ATF6	22
Large-scale, three-dimensional tissue cytometry of the human kidney: a complete and accessible pipeline	22
Crosstalk between progesterone receptor membrane component 1 and estrogen receptor α promotes breast cancer cell proliferation	21
GTSE1 promotes prostate cancer cell proliferation via the SP1/FOXM1 signaling pathway	21
Parthenolide alleviates peritoneal fibrosis by inhibiting inflammation via the NF-κB/ TGF-β/Smad signaling axis	21
Extracellular cold-inducible RNA-binding protein regulates neutrophil extracellular trap formation and tissue damage in acute pancreatitis	21
A mouse model for peritoneal metastases of colorectal origin recapitulates patient heterogeneity	21
The antioxidative stress regulator Nrf2 potentiates radioresistance of oral squamous cell carcinoma accompanied with metabolic modulation	20
Aryl Hydrocarbon Receptor Activation Coordinates Mouse Small Intestinal Epithelial Cell Programming	20
Phospholipase Cγ1 (PLCG1) overexpression is associated with tumor growth and poor survival in IDH wild-type lower-grade gliomas in adult patients	20
Feline low-grade intestinal T cell lymphoma: a unique natural model of human indolent T cell lymphoproliferative disorder of the gastrointestinal tract	19
Establishing standardized immune phenotyping of metastatic melanoma by digital pathology	19
Overexpression of pigment epithelium-derived factor in placenta-derived mesenchymal stem cells promotes mitochondrial biogenesis in retinal cells	19
DNA methyltransferase 1 (DNMT1) suppresses mitophagy and aggravates heart failure via the microRNA-152-3p/ETS1/RhoH axis	18
NFAT5 promotes oral squamous cell carcinoma progression in a hyperosmotic environment	18
SIRT6 regulates SREBP1c-induced glucolipid metabolism in liver and pancreas via the AMPKα-mTORC1 pathway	18
MicroRNA-130b functions as an oncogene and is a predictive marker of poor prognosis in lung adenocarcinoma	18
Steatosis, inflammasome upregulation, and fibrosis are attenuated in miR-155 deficient mice in a high fat-cholesterol-sugar diet-induced model of NASH	18
Impairment of corneal epithelial wound healing is association with increased neutrophil infiltration and reactive oxygen species activation in tenascin X-deficient mice	18
Mechanical loading activates the YAP/TAZ pathway and chemokine expression in the MLO-Y4 osteocyte-like cell line	18
Sox13 promotes hepatocellular carcinoma metastasis by transcriptionally activating Twist1	18
Ubiquitin-specific protease 35 (USP35) mediates cisplatin-induced apoptosis by stabilizing BIRC3 in non-small cell lung cancer	18
IL-37bΔ1-45 suppresses the migration and invasion of endometrial cancer cells by targeting the Rac1/NF-κB/MMP2 signal pathway	17

Adipose tissue inflammation and systemic insulin resistance in mice with diet-induced obesity is possibly associated with disruption of PFKFB3 in hematopoietic cells	17
Pretreatment with valproic acid alleviates pulmonary fibrosis through epithelial–mesenchymal transition inhibition in vitro and in vivo	17
SMAD4 mutation correlates with poor prognosis in non-small cell lung cancer	17
MiR-126-5p promotes contractile switching of aortic smooth muscle cells by targeting VEPH1 and alleviates Ang II-induced abdominal aortic aneurysm in mice	17
p53 Activates the Lipoxygenase Activity of ALOX15B via Inhibiting SLC7A11 to Induce Ferroptosis in Bladder Cancer Cells	16
Loss of ephrin B2 receptor (EPHB2) sets lipid rheostat by regulating proteins DGAT1 and ATGL inducing lipid droplet storage in prostate cancer cells	16
LncRNA SNHG5 upregulation induced by YY1 contributes to angiogenesis via miR-26b/CTGF/VEGFA axis in acute myelogenous leukemia	16
βCysteine 93 in human hemoglobin: a gateway to oxidative stability in health and disease	16
Nuclear exclusion of YAP exacerbates podocyte apoptosis and disease progression in Adriamycin-induced focal segmental glomerulosclerosis	16
Revolutionizing Digital Pathology With the Power of Generative Artificial Intelligence and Foundation Models	16
6-Gingerol relieves myocardial ischaemia/reperfusion injury by regulating lncRNA H19/miR-143/ATG7 signaling axis-mediated autophagy	16
miR-184 targets TP63 to block idiopathic pulmonary fibrosis by inhibiting proliferation and epithelial–mesenchymal transition of airway epithelial cells	16
SECISBP2 is a novel prognostic predictor that regulates selenoproteins in diffuse large B-cell lymphoma	16
Alternative activation of macrophages by prostacyclin synthase ameliorates alcohol induced liver injury	15
MiR-200c-3p targets SESN1 and represses the IL-6/AKT loop to prevent cholangiocyte activation and cholestatic liver fibrosis	15
Circulating tumor DNA profiling for childhood brain tumors: Technical challenges and evidence for utility	15
Reliability of liquid biopsy analysis: an inter-laboratory comparison of circulating tumor DNA extraction and sequencing with different platforms	15
A novel image signature-based radiomics method to achieve precise diagnosis and prognostic stratification of gliomas	15
Inhibition of syndecan-4 reduces cartilage degradation in murine models of osteoarthritis through the downregulation of HIF-2α by miR-96-5p	15
Exosomes derived from hypoxia-induced alveolar epithelial cells stimulate interstitial pulmonary fibrosis through a HOTAIRM1-dependent mechanism	14
αTAT1-induced tubulin acetylation promotes ameloblastoma migration and invasion	14
EZH2 is associated with cartilage degeneration in osteoarthritis by promoting SDC1 expression via histone methylation of the microRNA-138 promoter	14
Early pathogenesis of cystic fibrosis gallbladder disease in a porcine model	14
Anti-tumor effects of vitamin D in glioblastoma: mechanism and therapeutic implications	14
Hepatitis B virus core protein promotes the expression of neuraminidase 1 to facilitate hepatocarcinogenesis	14
lncRNA NEAT1 aggravates sepsis-induced lung injury by regulating the miR-27a/PTEN axis	14
LncRNA UCC promotes epithelial–mesenchymal transition via the miR-143-3p/SOX5 axis in non-small-cell lung cancer	14
Conventional histological and cytological staining with simultaneous immunohistochemistry enabled by invisible chromogens	14
Deepfake Histologic Images for Enhancing Digital Pathology	13
Monomeric C reactive protein (mCRP) regulates inflammatory responses in human and mouse chondrocytes	13
Exploring photoacoustic spectroscopy-based machine learning together with metabolomics to assess breast tumor progression in a xenograft model ex vivo	13
MicroRNA-432-5p regulates sprouting and intussusceptive angiogenesis in osteosarcoma microenvironment by targeting PDGFB	13
Ascorbate-induced oxidative stress mediates TRP channel activation and cytotoxicity in human etoposide-sensitive and -resistant retinoblastoma cells	13
Generation of heterozygous PKD1 mutant pigs exhibiting early-onset renal cyst formation	13
Cholestasis impairs hepatic lipid storage via AMPK and CREB signaling in hepatitis B virus surface protein transgenic mice	13
Cell-free plasma microRNAs that identify patients with glioblastoma	13
Bone morphogenetic protein induces bone invasion of melanoma by epithelial–mesenchymal transition via the Smad1/5 signaling pathway	13
Amelioration of circadian disruption and calcium-handling protein defects by choline alleviates cardiac remodeling in abdominal aorta coarctation rats	12
CP-25 alleviates antigen-induced experimental Sjögren's syndrome in mice by inhibiting JAK1-STAT1/2-CXCL13 signaling and interfering with B-cell migration	12
Long noncoding Mirt2 reduces apoptosis to alleviate myocardial infarction through regulation of the miR-764/PDK1 axis	12
Induction of cancer cell stemness in glioma through glycolysis and the long noncoding RNA HULC-activated FOXM1/AGR2/HIF-1α axis	12
TRIM27 contributes to glomerular endothelial cell injury in lupus nephritis by mediating the FoxO1 signaling pathway	12
Inhibitory effects of temozolomide on glioma cells is sensitized by RSL3-induced ferroptosis but negatively correlated with expression of ferritin heavy chain 1 and ferritin light chain	12
Predicting 1p/19q co-deletion status from magnetic resonance imaging using deep learning in adult-type diffuse lower-grade gliomas: a discovery and validation study	12
Resveratrol promotes skin wound healing by regulating the miR-212/CASP8 axis	12
A novel human endometrial epithelial cell line for modeling gynecological diseases and for drug screening	12
5-HT7 receptor-dependent intestinal neurite outgrowth contributes to visceral hypersensitivity in irritable bowel syndrome	12
Evaluation of an EZH2 inhibitor in patient-derived orthotopic xenograft models of pediatric brain tumors alone and in combination with chemo- and radiation therapies	12
CircN4BP2L2 promotes colorectal cancer growth and metastasis through regulation of the miR-340-5p/CXCR4 axis	12
Dissection of PD-L1 promoter reveals differential transcriptional regulation of PD-L1 in VHL mutant clear cell renal cell carcinoma	12
Silencing of LINC01963 enhances the chemosensitivity of prostate cancer cells to docetaxel by targeting the miR-216b-5p/TrkB axis	12
circHECTD1 attenuates apoptosis of alveolar epithelial cells in acute lung injury	12
A MXI1-NUTM1 fusion protein with MYC-like activity suggests a novel oncogenic mechanism in a subset of NUTM1-rearranged tumors	12
Analysis of DNA variants in miRNAs and miRNA 3ʼUTR binding sites in female infertility patients	12
MicroRNA-483-5p accentuates cisplatin-induced acute kidney injury by targeting GPX3	12
Generation of a new immortalized human lung pericyte cell line: a promising tool for human lung pericyte studies	12
Upregulation of KLHL17 promotes the proliferation and migration of non-small cell lung cancer by activating the Ras/MAPK signaling pathway	12
GTSE1 promotes tumor growth and metastasis by attenuating of KLF4 expression in clear cell renal cell carcinoma	11
Multimetric feature selection for analyzing multicategory outcomes of colorectal cancer: random forest and multinomial logistic regression models	11
LncRNA ROR modulates myocardial ischemia-reperfusion injury mediated by the miR-185-5p/CDK6 axis	11
Commensal gut bacterium critically regulates alveolar bone homeostasis	11
Long non-coding RNA MALAT1 enhances angiogenesis during bone regeneration by regulating the miR-494/SP1 axis	11
Distinct transcriptional programs of SOX2 in different types of small cell lung cancers	11
LINC01419-mediated epigenetic silencing of ZIC1 promotes metastasis in hepatocellular carcinoma through the PI3K/Akt signaling pathway	11
Genetic loss-of-function of activating transcription factor 3 but not C-type lectin member 5A prevents diabetic peripheral neuropathy	11
PLODs are overexpressed in ovarian cancer and are associated with gap junctions via connexin 43	11
Vitamin E relieves chronic obstructive pulmonary disease by inhibiting COX2-mediated p-STAT3 nuclear translocation through the EGFR/MAPK signaling pathway	11
LncRNA SNHG15 relieves hyperglycemia-induced endothelial dysfunction via increased ubiquitination of thioredoxin-interacting protein	11
Interpretable tumor differentiation grade and microsatellite instability recognition in gastric cancer using deep learning	11
PHLDA3 promotes lung adenocarcinoma cell proliferation and invasion via activation of the Wnt signaling pathway	11
A new technological approach in diagnostic pathology: mass spectrometry imaging-based metabolomics for biomarker detection in urachal cancer	11
Unstained Tissue Imaging and Virtual Hematoxylin and Eosin Staining of Histologic Whole Slide Images	10
Development of an immunohistochemical assay for Siglec-15	10
Quantitative analysis of abnormalities in gynecologic cytopathology with deep learning	10
Tubeimoside I improves endothelial function in sepsis via activation of SIRT3	10
Pharmacological inhibition of serine synthesis enhances temozolomide efficacy by decreasing O6-methylguanine DNA methyltransferase (MGMT) expression and reactive oxygen species (ROS)-mediated DNA dama	10
Reversal of hypertriglyceridemia in diabetic BTBR ob/ob mice does not prevent nephropathy	10
circ_rac GTPase–Activating Protein 1 Facilitates Stemness and Metastasis of Non–Small Cell Lung Cancer via Polypyrimidine Tract–Binding Protein 1 Recruitment to Promote Sirtuin-3–Mediated Replication	10
Novel role of the dietary flavonoid fisetin in suppressing rRNA biogenesis	10
Advances in neuroendocrine prostate cancer research: From model construction to molecular network analyses	10

NLRP3 deficiency did not attenuate NASH development under high fat calorie diet plus high fructose and glucose in drinking water	10
Assessing the utility of long-read nanopore sequencing for rapid and efficient characterization of mobile element insertions	10
Loss of sphingosine 1-phosphate receptor 3 gene function impairs injury-induced stromal angiogenesis in mouse cornea	10
The N6-methyladenosine writer WTAP contributes to the induction of immune tolerance post kidney transplantation by targeting regulatory T cells	10
Bone mesenchymal stem cell-derived extracellular vesicles containing NORAD promote osteosarcoma by miR-30c-5p	10
ZKSCAN3 in severe bacterial lung infection and sepsis-induced immunosuppression	10
Early response in phosphorylation of ribosomal protein S6 is associated with sensitivity to trametinib in colorectal cancer cells	10
A generative adversarial approach to facilitate archival-quality histopathologic diagnoses from frozen tissue sections	10
The MFF-SIRT1/3 axis, regulated by miR-340-5p, restores mitochondrial homeostasis of hypoxia-induced pulmonary artery smooth muscle cells	10
AccuCor2: isotope natural abundance correction for dual-isotope tracer experiments	10
A novel tree shrew model of pulmonary fibrosis	10
Diagnosis of Alzheimer Disease and Tauopathies on Whole-Slide Histopathology Images Using a Weakly Supervised Deep Learning Algorithm	10
Osr1 regulates hepatic inflammation and cell survival in the progression of non-alcoholic fatty liver disease	9
High levels of TIMP1 are associated with increased extracellular matrix stiffness in isocitrate dehydrogenase 1-wild type gliomas	9
L-carnitine suppresses transient receptor potential vanilloid type 1 activity and myofibroblast transdifferentiation in human corneal keratocytes	9
Potential role for EZH2 in promotion of asthma through suppression of miR-34b transcription by inhibition of FOXO3	9
Phenotyping clonal populations of glioma stem cell reveals a high degree of plasticity in response to changes of microenvironment	9
Fibroblast growth factor 21, a stress regulator, inhibits Drp1 activation to alleviate skeletal muscle ischemia/reperfusion injury	9
DDAH-1, via regulation of ADMA levels, protects against ischemia-induced blood-brain barrier leakage	9
Protein-based immune profiles of basal-like vs. luminal breast cancers	9
Synergistic upregulation of ADAMTS4 (aggrecanase-1) by cytokines and its suppression in knee osteoarthritic synovial fibroblasts	9
Collagen XVII deficiency alters epidermal patterning	9
Detection of Helicobacter pylori Infection in Human Gastric Fluid Through Surface-Enhanced Raman Spectroscopy Coupled With Machine Learning Algorithms	9
ATF-3 expression inhibits melanoma growth by downregulating ERK and AKT pathways	9
Granzyme B Contributes to Choroidal Neovascularization and Age-Related Macular Degeneration Through Proteolysis of Thrombospondin-1	9
SLUG is a key regulator of epithelial-mesenchymal transition in pleomorphic adenoma	9
Programmed death-1 promotes contused skeletal muscle regeneration by regulating Treg cells and macrophages	9
Photoactivatable Cre knock-in mice for spatiotemporal control of genetic engineering in vivo	9
Serotonin-induced vascular permeability is mediated by transient receptor potential vanilloid 4 in the airways and upper gastrointestinal tract of mice	9
A time-course Raman spectroscopic analysis of spontaneous in vitro microcalcifications in a breast cancer cell line	9