Laboratory Investigation

Article	Citations
Artificial intelligence and computational pathology	254
High-throughput proteomics: a methodological mini-review	100
Grading of adult diffuse gliomas according to the 2021 WHO Classification of Tumors of the Central Nervous System	78
Detection of SARS-CoV-2 in formalin-fixed paraffin-embedded tissue sections using commercially available reagents	74
Adipose mesenchymal stem cell-derived exosomes accelerate skin wound healing via the lncRNA H19/miR-19b/SOX9 axis	65
Quantitative measurement of HER2 expression to subclassify ERBB2 unamplified breast cancer	58
Multiplexed ion beam imaging (MIBI) for characterization of the tumor microenvironment across tumor types	54
CCL3–CCR5 axis contributes to progression of esophageal squamous cell carcinoma by promoting cell migration and invasion via Akt and ERK pathways	49
N-methyladenosine reader YTHDF2-mediated long noncoding RNA FENDRR degradation promotes cell proliferation in endometrioid endometrial carcinoma	46
Deep learning shows the capability of high-level computer-aided diagnosis in malignant lymphoma	45
Vascular remodeling by placenta-derived mesenchymal stem cells restores ovarian function in ovariectomized rat model via the VEGF pathway	42
PAI-1 derived from cancer-associated fibroblasts in esophageal squamous cell carcinoma promotes the invasion of cancer cells and the migration of macrophages	40
Advancements in detection of SARS-CoV-2 infection for confronting COVID-19 pandemics	40
Deep-learning-based accurate hepatic steatosis quantification for histological assessment of liver biopsies	38
MicroRNA-182 improves spinal cord injury in mice by modulating apoptosis and the inflammatory response via IKKβ/NF-κB	36
CircRNA-ST6GALNAC6 increases the sensitivity of bladder cancer cells to erastin-induced ferroptosis by regulating the HSPB1/P38 axis	34
Exosomal tau with seeding activity is released from Alzheimer's disease synapses, and seeding potential is associated with amyloid beta	34
Th17/IL-17 induces endothelial cell senescence via activation of NF-κB/p53/Rb signaling pathway	34
The lncRNA XIST/miR-150-5p/c-Fos axis regulates sepsis-induced myocardial injury via TXNIP-modulated pyroptosis	34
Predictive modeling of estrogen receptor agonism, antagonism, and binding activities using machine- and deep-learning approaches	32
Fibronectin 1 activates WNT/β-catenin signaling to induce osteogenic differentiation via integrin β1 interaction	32
Exercise suppresses NLRP3 inflammasome activation in mice with diet-induced NASH: a plausible role of adropin	31
Exosomes derived from hypoxic glioma deliver miR-1246 and miR-10b-5p to normoxic glioma cells to promote migration and invasion	31
Nicotinamide riboside, an NAD+ precursor, attenuates inflammation and oxidative stress by activating sirtuin 1 in alcohol-stimulated macrophages	31
Establishing a living biobank of patient-derived organoids of intraductal papillary mucinous neoplasms of the pancreas	31

Brightfield multiplex immunohistochemistry with multispectral imaging	31
Matrix metalloproteinase 11 (MMP11) in macrophages promotes the migration of HER2-positive breast cancer cells and monocyte recruitment through CCL2–CCR2 signaling	30
LncRNA GAS5 activates the HIF1A/VEGF pathway by binding to TAF15 to promote wound healing in diabetic foot ulcers	30
Pseudomonas aeruginosa virulence proteins pseudolysin and protease IV impede cutaneous wound healing	29
Curcumin attenuates Adriamycin-resistance of acute myeloid leukemia by inhibiting the lncRNA HOTAIR/miR-20a-5p/WT1 axis	29
3′ MACE RNA-sequencing allows for transcriptome profiling in human tissue samples after long-term storage	29
CircPAN3 ameliorates myocardial ischaemia/reperfusion injury by targeting miR-421/Pink1 axis-mediated autophagy suppression	29
Human urine-derived stem cell-derived exosomal miR-21-5p promotes neurogenesis to attenuate Rett syndrome via the EPha4/TEK axis	28
LncRNA XIST shuttled by adipose tissue-derived mesenchymal stem cell-derived extracellular vesicles suppresses myocardial pyroptosis in atrial fibrillation by disrupting miR-214-3p-mediated Arl2 inhib	28
M1 macrophage-derived exosomes transfer miR-222 to induce bone marrow mesenchymal stem cell apoptosis	27
Sporadic and Lynch syndrome-associated mismatch repair-deficient brain tumors	27
Mechanical strain induces phenotypic changes in breast cancer cells and promotes immunosuppression in the tumor microenvironment	27
CD38 in cancer-associated fibroblasts promotes pro-tumoral activity	25
Quantitative assessment of inflammatory infiltrates in kidney transplant biopsies using multiplex tyramide signal amplification and deep learning	25
SPOCK1 overexpression induced by platelet-derived growth factor-BB promotes hepatic stellate cell activation and liver fibrosis through the integrin α5β1/PI3K/Akt signaling pathway	25
Hepatocyte-specific fibroblast growth factor 21 overexpression ameliorates high-fat diet-induced obesity and liver steatosis in mice	25
A convolutional neural network model for survival prediction based on prognosis-related cascaded Wx feature selection	25
Digital quantitative assessment of PD-L1 using digital spatial profiling	25
Deep learning-based grading of ductal carcinoma in situ in breast histopathology images	25
MiR-221-3p targets Hif-1α to inhibit angiogenesis in heart failure	25
Kras mutation rate precisely orchestrates ductal derived pancreatic intraepithelial neoplasia and pancreatic cancer	24
Inhibition of miR-181a-5p reduces astrocyte and microglia activation and oxidative stress by activating SIRT1 in immature rats with epilepsy	24
Extracellular vesicles derived from M2 microglia reduce ischemic brain injury through microRNA-135a-5p/TXNIP/NLRP3 axis	24
Performance and efficiency of machine learning algorithms for analyzing rectangular biomedical data	24
Angiotensin-converting enzyme 2 influences pancreatic and renal function in diabetic mice	24
Enhanced alcoholic liver disease in mice with intestine-specific farnesoid X receptor deficiency	24
LncRNA MAPKAPK5_AS1 facilitates cell proliferation in hepatitis B virus -related hepatocellular carcinoma	23
GestAltNet: aggregation and attention to improve deep learning of gestational age from placental whole-slide images	23
LncRNA SLCO4A1-AS1 modulates colon cancer stem cell properties by binding to miR-150-3p and positively regulating SLCO4A1	23
Large-scale, three-dimensional tissue cytometry of the human kidney: a complete and accessible pipeline	22
Reproducible, high-dimensional imaging in archival human tissue by multiplexed ion beam imaging by time-of-flight (MIBI-TOF)	22
Characterization of COVID-19-associated cardiac injury: evidence for a multifactorial disease in an autopsy cohort	22
MiR-185-5p ameliorates endoplasmic reticulum stress and renal fibrosis by downregulation of ATF6	22
Blocking thrombospondin-1 signaling via CD47 mitigates renal interstitial fibrosis	22
The HNRNPA2B1–MST1R–Akt axis contributes to epithelial-to-mesenchymal transition in head and neck cancer	22
Bioglass promotes wound healing by inhibiting endothelial cell pyroptosis through regulation of the connexin 43/reactive oxygen species (ROS) signaling pathway	22
Distinct macrophage polarization in acute and chronic gout	22
The role of macrophage–fibroblast interaction in lipopolysaccharide-induced pulmonary fibrosis: an acceleration in lung fibroblast aerobic glycolysis	22
Characterization of pathological thyroid tissue using polarization-sensitive second harmonic generation microscopy	22
FABP4 activates the JAK2/STAT2 pathway via Rap1a in the homocysteine-induced macrophage inflammatory response in ApoE mice atherosclerosis	22
The synthetic toxin biliatresone causes biliary atresia in mice	20
Crosstalk between progesterone receptor membrane component 1 and estrogen receptor α promotes breast cancer cell proliferation	20
Molecular signatures of tumor progression in myxoid liposarcoma identified by N-glycan mass spectrometry imaging	20
Identification of differentially expressed genes in lung adenocarcinoma cells using single-cell RNA sequencing not detected using traditional RNA sequencing and microarray	20
Extracellular cold-inducible RNA-binding protein regulates neutrophil extracellular trap formation and tissue damage in acute pancreatitis	20
A mouse model for peritoneal metastases of colorectal origin recapitulates patient heterogeneity	20
Sustained hedgehog signaling in medulloblastoma tumoroids is attributed to stromal astrocytes and astrocyte-derived extracellular matrix	19
Feline low-grade intestinal T cell lymphoma: a unique natural model of human indolent T cell lymphoproliferative disorder of the gastrointestinal tract	19
GTSE1 promotes prostate cancer cell proliferation via the SP1/FOXM1 signaling pathway	19
The antioxidative stress regulator Nrf2 potentiates radioresistance of oral squamous cell carcinoma accompanied with metabolic modulation	19

Impairment of corneal epithelial wound healing is association with increased neutrophil infiltration and reactive oxygen species activation in tenascin X-deficient mice	18
SIRT6 regulates SREBP1c-induced glucolipid metabolism in liver and pancreas via the AMPKα-mTORC1 pathway	18
Ubiquitin-specific protease 35 (USP35) mediates cisplatin-induced apoptosis by stabilizing BIRC3 in non-small cell lung cancer	18
Phospholipase Cγ1 (PLCG1) overexpression is associated with tumor growth and poor survival in IDH wild-type lower-grade gliomas in adult patients	18
NFAT5 promotes oral squamous cell carcinoma progression in a hyperosmotic environment	18
Overexpression of pigment epithelium-derived factor in placenta-derived mesenchymal stem cells promotes mitochondrial biogenesis in retinal cells	18
Steatosis, inflammasome upregulation, and fibrosis are attenuated in miR-155 deficient mice in a high fat-cholesterol-sugar diet-induced model of NASH	17
MiR-126-5p promotes contractile switching of aortic smooth muscle cells by targeting VEPH1 and alleviates Ang II-induced abdominal aortic aneurysm in mice	17
Standardized Pathology Screening of Mature Tertiary Lymphoid Structures in Cancers	17
Mechanical loading activates the YAP/TAZ pathway and chemokine expression in the MLO-Y4 osteocyte-like cell line	17
DNA methyltransferase 1 (DNMT1) suppresses mitophagy and aggravates heart failure via the microRNA-152-3p/ETS1/RhoH axis	17
Parthenolide alleviates peritoneal fibrosis by inhibiting inflammation via the NF-κB/ TGF-β/Smad signaling axis	17
MicroRNA-130b functions as an oncogene and is a predictive marker of poor prognosis in lung adenocarcinoma	17
Establishing standardized immune phenotyping of metastatic melanoma by digital pathology	17
IL-37bΔ1-45 suppresses the migration and invasion of endometrial cancer cells by targeting the Rac1/NF-κB/MMP2 signal pathway	16
SECISBP2 is a novel prognostic predictor that regulates selenoproteins in diffuse large B-cell lymphoma	16
Sox13 promotes hepatocellular carcinoma metastasis by transcriptionally activating Twist1	16
miR-184 targets TP63 to block idiopathic pulmonary fibrosis by inhibiting proliferation and epithelial–mesenchymal transition of airway epithelial cells	16
βCysteine 93 in human hemoglobin: a gateway to oxidative stability in health and disease	16
Adipose tissue inflammation and systemic insulin resistance in mice with diet-induced obesity is possibly associated with disruption of PFKFB3 in hematopoietic cells	16
LncRNA SNHG5 upregulation induced by YY1 contributes to angiogenesis via miR-26b/CTGF/VEGFA axis in acute myelogenous leukemia	16
Aryl Hydrocarbon Receptor Activation Coordinates Mouse Small Intestinal Epithelial Cell Programming	16
Pretreatment with valproic acid alleviates pulmonary fibrosis through epithelial–mesenchymal transition inhibition in vitro and in vivo	15
Nuclear exclusion of YAP exacerbates podocyte apoptosis and disease progression in Adriamycin-induced focal segmental glomerulosclerosis	15
A novel image signature-based radiomics method to achieve precise diagnosis and prognostic stratification of gliomas	15
MiR-200c-3p targets SESN1 and represses the IL-6/AKT loop to prevent cholangiocyte activation and cholestatic liver fibrosis	15
Reliability of liquid biopsy analysis: an inter-laboratory comparison of circulating tumor DNA extraction and sequencing with different platforms	15
SMAD4 mutation correlates with poor prognosis in non-small cell lung cancer	15
6-Gingerol relieves myocardial ischaemia/reperfusion injury by regulating lncRNA H19/miR-143/ATG7 signaling axis-mediated autophagy	15
p53 Activates the Lipoxygenase Activity of ALOX15B via Inhibiting SLC7A11 to Induce Ferroptosis in Bladder Cancer Cells	15
Loss of ephrin B2 receptor (EPHB2) sets lipid rheostat by regulating proteins DGAT1 and ATGL inducing lipid droplet storage in prostate cancer cells	15
Alternative activation of macrophages by prostacyclin synthase ameliorates alcohol induced liver injury	14
EZH2 is associated with cartilage degeneration in osteoarthritis by promoting SDC1 expression via histone methylation of the microRNA-138 promoter	14
Circulating tumor DNA profiling for childhood brain tumors: Technical challenges and evidence for utility	14
Deepfake Histologic Images for Enhancing Digital Pathology	13
Monomeric C reactive protein (mCRP) regulates inflammatory responses in human and mouse chondrocytes	13
LncRNA UCC promotes epithelial–mesenchymal transition via the miR-143-3p/SOX5 axis in non-small-cell lung cancer	13
Conventional histological and cytological staining with simultaneous immunohistochemistry enabled by invisible chromogens	13
Cholestasis impairs hepatic lipid storage via AMPK and CREB signaling in hepatitis B virus surface protein transgenic mice	13
αTAT1-induced tubulin acetylation promotes ameloblastoma migration and invasion	13
Exploring photoacoustic spectroscopy-based machine learning together with metabolomics to assess breast tumor progression in a xenograft model ex vivo	13
lncRNA NEAT1 aggravates sepsis-induced lung injury by regulating the miR-27a/PTEN axis	13
Anti-tumor effects of vitamin D in glioblastoma: mechanism and therapeutic implications	13
Generation of heterozygous PKD1 mutant pigs exhibiting early-onset renal cyst formation	13
Silencing of LINC01963 enhances the chemosensitivity of prostate cancer cells to docetaxel by targeting the miR-216b-5p/TrkB axis	12
Analysis of DNA variants in miRNAs and miRNA 3ʼUTR binding sites in female infertility patients	12
Evaluation of an EZH2 inhibitor in patient-derived orthotopic xenograft models of pediatric brain tumors alone and in combination with chemo- and radiation therapies	12
Inhibitory effects of temozolomide on glioma cells is sensitized by RSL3-induced ferroptosis but negatively correlated with expression of ferritin heavy chain 1 and ferritin light chain	12
Predicting 1p/19q co-deletion status from magnetic resonance imaging using deep learning in adult-type diffuse lower-grade gliomas: a discovery and validation study	12
CP-25 alleviates antigen-induced experimental Sjögren's syndrome in mice by inhibiting JAK1-STAT1/2-CXCL13 signaling and interfering with B-cell migration	12
Long noncoding Mirt2 reduces apoptosis to alleviate myocardial infarction through regulation of the miR-764/PDK1 axis	12
MicroRNA-432-5p regulates sprouting and intussusceptive angiogenesis in osteosarcoma microenvironment by targeting PDGFB	12
Early pathogenesis of cystic fibrosis gallbladder disease in a porcine model	12
Amelioration of circadian disruption and calcium-handling protein defects by choline alleviates cardiac remodeling in abdominal aorta coarctation rats	12
Hepatitis B virus core protein promotes the expression of neuraminidase 1 to facilitate hepatocarcinogenesis	12
A MXI1-NUTM1 fusion protein with MYC-like activity suggests a novel oncogenic mechanism in a subset of NUTM1-rearranged tumors	12
TRIM27 contributes to glomerular endothelial cell injury in lupus nephritis by mediating the FoxO1 signaling pathway	12
CircN4BP2L2 promotes colorectal cancer growth and metastasis through regulation of the miR-340-5p/CXCR4 axis	12
Generation of a new immortalized human lung pericyte cell line: a promising tool for human lung pericyte studies	11
LINC01419-mediated epigenetic silencing of ZIC1 promotes metastasis in hepatocellular carcinoma through the PI3K/Akt signaling pathway	11
Multimetric feature selection for analyzing multicategory outcomes of colorectal cancer: random forest and multinomial logistic regression models	11
Resveratrol promotes skin wound healing by regulating the miR-212/CASP8 axis	11
PLODs are overexpressed in ovarian cancer and are associated with gap junctions via connexin 43	11
Long non-coding RNA MALAT1 enhances angiogenesis during bone regeneration by regulating the miR-494/SP1 axis	11
Exosomes derived from hypoxia-induced alveolar epithelial cells stimulate interstitial pulmonary fibrosis through a HOTAIRM1-dependent mechanism	11
Dissection of PD-L1 promoter reveals differential transcriptional regulation of PD-L1 in VHL mutant clear cell renal cell carcinoma	11
The transient receptor potential vanilloid 4 (TRPV4) ion channel mediates protease activated receptor 1 (PAR1)-induced vascular hyperpermeability	11
Inhibition of syndecan-4 reduces cartilage degradation in murine models of osteoarthritis through the downregulation of HIF-2α by miR-96-5p	11
5-HT7 receptor-dependent intestinal neurite outgrowth contributes to visceral hypersensitivity in irritable bowel syndrome	11
Distinct transcriptional programs of SOX2 in different types of small cell lung cancers	11
Ascorbate-induced oxidative stress mediates TRP channel activation and cytotoxicity in human etoposide-sensitive and -resistant retinoblastoma cells	11
LncRNA SNHG15 relieves hyperglycemia-induced endothelial dysfunction via increased ubiquitination of thioredoxin-interacting protein	11
Vasoinhibin reduces joint inflammation, bone loss, and the angiogenesis and vasopermeability of the pannus in murine antigen-induced arthritis	11
A novel human endometrial epithelial cell line for modeling gynecological diseases and for drug screening	11
Bone morphogenetic protein induces bone invasion of melanoma by epithelial–mesenchymal transition via the Smad1/5 signaling pathway	11
ZKSCAN3 in severe bacterial lung infection and sepsis-induced immunosuppression	10
circHECTD1 attenuates apoptosis of alveolar epithelial cells in acute lung injury	10
NLRP3 deficiency did not attenuate NASH development under high fat calorie diet plus high fructose and glucose in drinking water	10
Assessing the utility of long-read nanopore sequencing for rapid and efficient characterization of mobile element insertions	10
MicroRNA-483-5p accentuates cisplatin-induced acute kidney injury by targeting GPX3	10

Pharmacological inhibition of serine synthesis enhances temozolomide efficacy by decreasing O6-methylguanine DNA methyltransferase (MGMT) expression and reactive oxygen species (ROS)-mediated DNA dama	10
Upregulation of KLHL17 promotes the proliferation and migration of non-small cell lung cancer by activating the Ras/MAPK signaling pathway	10
Bone mesenchymal stem cell-derived extracellular vesicles containing NORAD promote osteosarcoma by miR-30c-5p	10
Characterization of colorectal mucus using infrared spectroscopy: a potential target for bowel cancer screening and diagnosis	10
Early response in phosphorylation of ribosomal protein S6 is associated with sensitivity to trametinib in colorectal cancer cells	10
Development of an immunohistochemical assay for Siglec-15	10
Induction of cancer cell stemness in glioma through glycolysis and the long noncoding RNA HULC-activated FOXM1/AGR2/HIF-1α axis	10
GTSE1 promotes tumor growth and metastasis by attenuating of KLF4 expression in clear cell renal cell carcinoma	10
Interpretable tumor differentiation grade and microsatellite instability recognition in gastric cancer using deep learning	10
Loss of sphingosine 1-phosphate receptor 3 gene function impairs injury-induced stromal angiogenesis in mouse cornea	10
Genetic loss-of-function of activating transcription factor 3 but not C-type lectin member 5A prevents diabetic peripheral neuropathy	10
Novel role of the dietary flavonoid fisetin in suppressing rRNA biogenesis	10
Commensal gut bacterium critically regulates alveolar bone homeostasis	10
A generative adversarial approach to facilitate archival-quality histopathologic diagnoses from frozen tissue sections	10
Vitamin E relieves chronic obstructive pulmonary disease by inhibiting COX2-mediated p-STAT3 nuclear translocation through the EGFR/MAPK signaling pathway	10
LncRNA ROR modulates myocardial ischemia-reperfusion injury mediated by the miR-185-5p/CDK6 axis	10
Reversal of hypertriglyceridemia in diabetic BTBR ob/ob mice does not prevent nephropathy	10
AccuCor2: isotope natural abundance correction for dual-isotope tracer experiments	10
PHLDA3 promotes lung adenocarcinoma cell proliferation and invasion via activation of the Wnt signaling pathway	10
Osr1 regulates hepatic inflammation and cell survival in the progression of non-alcoholic fatty liver disease	9
The N6-methyladenosine writer WTAP contributes to the induction of immune tolerance post kidney transplantation by targeting regulatory T cells	9
Diagnosis of Alzheimer Disease and Tauopathies on Whole-Slide Histopathology Images Using a Weakly Supervised Deep Learning Algorithm	9
A time-course Raman spectroscopic analysis of spontaneous in vitro microcalcifications in a breast cancer cell line	9
Cell-free plasma microRNAs that identify patients with glioblastoma	9
DDAH-1, via regulation of ADMA levels, protects against ischemia-induced blood-brain barrier leakage	9
Protein-based immune profiles of basal-like vs. luminal breast cancers	9
A novel tree shrew model of pulmonary fibrosis	9
Serotonin-induced vascular permeability is mediated by transient receptor potential vanilloid 4 in the airways and upper gastrointestinal tract of mice	9
A new technological approach in diagnostic pathology: mass spectrometry imaging-based metabolomics for biomarker detection in urachal cancer	9
Tubeimoside I improves endothelial function in sepsis via activation of SIRT3	9
Potential role for EZH2 in promotion of asthma through suppression of miR-34b transcription by inhibition of FOXO3	9
Programmed death-1 promotes contused skeletal muscle regeneration by regulating Treg cells and macrophages	9
Quantitative analysis of abnormalities in gynecologic cytopathology with deep learning	9
Synergistic upregulation of ADAMTS4 (aggrecanase-1) by cytokines and its suppression in knee osteoarthritic synovial fibroblasts	8
A soluble endoplasmic reticulum factor as regenerative therapy for Wolfram syndrome	8
Nitric oxide-targeted therapy inhibits stemness and increases the efficacy of tamoxifen in estrogen receptor-positive breast cancer cells	8
An active learning approach for clustering single-cell RNA-seq data	8
Revolutionizing Digital Pathology With the Power of Generative Artificial Intelligence and Foundation Models	8
Fibroblast growth factor 21, a stress regulator, inhibits Drp1 activation to alleviate skeletal muscle ischemia/reperfusion injury	8
Nesfatin-1 exerts protective effects on acidosis-stimulated chondrocytes and rats with adjuvant-induced arthritis by inhibiting ASIC1a expression	8
Stress can attenuate hepatic lipid accumulation via elevation of hepatic β-muricholic acid levels in mice with nonalcoholic steatohepatitis	8
Deficiency of C-X-C chemokine receptor type 5 (CXCR5) gene causes dysfunction of retinal pigment epithelium cells	8
High levels of TIMP1 are associated with increased extracellular matrix stiffness in isocitrate dehydrogenase 1-wild type gliomas	8
Real-time lipid patterns to classify viable and necrotic liver tumors	8
Surfactant protein A modulates the activities of the JAK/STAT pathway in suppressing Th1 and Th17 polarization in murine OVA-induced allergic asthma	8
Overexpression of carnitine palmitoyltransferase 1A promotes mitochondrial fusion and differentiation of glioblastoma stem cells	8
Advanced detection strategies for cardiotropic virus infection in a cohort study of heart failure patients	8
ATF-3 expression inhibits melanoma growth by downregulating ERK and AKT pathways	8
Establishing the ground squirrel as a superb model for retinal ganglion cell disorders and optic neuropathies	8
The MFF-SIRT1/3 axis, regulated by miR-340-5p, restores mitochondrial homeostasis of hypoxia-induced pulmonary artery smooth muscle cells	8
Extracellular vesicles derived from miR-199a-5p-modified adipose-derived mesenchymal stem cells alleviate immune thrombocytopenia by inhibiting T helper 17 differentiation	8
L-carnitine suppresses transient receptor potential vanilloid type 1 activity and myofibroblast transdifferentiation in human corneal keratocytes	8
Digitization of Pathology Labs: A Review of Lessons Learned	8
Photoactivatable Cre knock-in mice for spatiotemporal control of genetic engineering in vivo	8
Unstained Tissue Imaging and Virtual Hematoxylin and Eosin Staining of Histologic Whole Slide Images	8
Nuclear receptor binding factor 2 (NRBF2) is required for learning and memory	8
CpG-SNP site methylation regulates allele-specific expression of MTHFD1 gene in type 2 diabetes	8
SLUG is a key regulator of epithelial-mesenchymal transition in pleomorphic adenoma	8
Molecular landscape of pediatric type IDH wildtype, H3 wildtype hemispheric glioblastomas	7
LncRNA GAS5 regulates migration and epithelial-to-mesenchymal transition in lens epithelial cells via the miR-204-3p/TGFBR1 axis	7
The S100A10–AnxA2 complex is associated with the exocytosis of hepatitis B virus in intrauterine infection	7
Collagen XVII deficiency alters epidermal patterning	7
Experimental models of undifferentiated pleomorphic sarcoma and malignant peripheral nerve sheath tumor	7
Berberine Ameliorates Abnormal Lipid Metabolism via the Adenosine Monophosphate–Activated Protein Kinase/Sirtuin 1 Pathway in Alcohol-Related Liver Disease	7
Role of Snai2 and Notch signaling in salivary gland myoepithelial cell fate	7
Clinical implications of exosome-derived noncoding RNAs in liver	7
Hyperglycemia promotes myocardial dysfunction via the ERS-MAPK10 signaling pathway in db/db mice	7
Histone H2B induces retinal ganglion cell death through toll-like receptor 4 in the vitreous of acute primary angle closure patients	7
Phenotyping clonal populations of glioma stem cell reveals a high degree of plasticity in response to changes of microenvironment	7
Granzyme B Contributes to Choroidal Neovascularization and Age-Related Macular Degeneration Through Proteolysis of Thrombospondin-1	7
Retinoblastoma tumor cell proliferation is negatively associated with an immune gene expression signature and increased immune cells	7
ASIC1a promotes the proliferation of synovial fibroblasts via the ERK/MAPK pathway	7
Inhibition of TXNDC5 attenuates lipopolysaccharide-induced septic shock by altering inflammatory responses	7
Advances in neuroendocrine prostate cancer research: From model construction to molecular network analyses	7
Increased talin–vinculin spatial proximities in livers in response to spotted fever group rickettsial and Ebola virus infections	7
Simultaneous metabolite MALDI-MSI, whole exome and transcriptome analysis from formalin-fixed paraffin-embedded tissue sections	6
Quantitative assessment of Siglec-15 expression in lung, breast, head, and neck squamous cell carcinoma and bladder cancer	6
Evaluating and comparing immunostaining and computational methods for spatial profiling of drug response in patient-derived explants	6
Smoothened (SMO) regulates insulin-like growth factor 1 receptor (IGF1R) levels and protein kinase B (AKT) localization and signaling	6
Pathophysiological mechanisms underlying a rat model of triple whammy acute kidney injury	6
Quantitative 3-dimensional imaging and tissue cytometry reveals lymphatic expansion in acute kidney injury	6
MicroRNA-26a-5p Restoration Ameliorates Unilateral Ureteral Obstruction-Induced Renal Fibrosis in Mice Through Modulating TGF-β Signaling	6
Increased chemosensitivity via BRCA2-independent DNA damage in DSS1- and PCID2-depleted breast carcinomas	6
Development of a Pathomics-Based Model for the Prediction of Malignant Transformation in Oral Leukoplakia	6
COVID-19 and graft-versus-host disease: a tale of two diseases (and why age matters)	6
Deep convolutional neural network-based algorithm for muscle biopsy diagnosis	6
Development of an exosomal gene signature to detect residual disease in dogs with osteosarcoma using a novel xenograft platform and machine learning	6
An improved assay for detection of theranostic gene translocations and MET exon 14 skipping in thoracic oncology	6
Using Artificial Intelligence to Identify Tumor Microenvironment Heterogeneity in Non–Small Cell Lung Cancers	6
RNA adenosine deaminase (ADAR1) alleviates high-fat diet-induced nonalcoholic fatty liver disease by inhibiting NLRP3 inflammasome	6
Fluvastatin sensitizes pancreatic cancer cells toward radiation therapy and suppresses radiation- and/or TGF-β-induced tumor-associated fibrosis	6
PAQR3 depletion accelerates diabetic wound healing by promoting angiogenesis through inhibiting STUB1-mediated PPARγ degradation	6
Utilizing tandem mass spectrometry for metabolic flux analysis	6
PCP4/PEP19 downregulates neurite outgrowth via transcriptional regulation of Ascl1 and NeuroD1 expression in human neuroblastoma M17 cells	6
Ubiquitin-specific protease 3 facilitates cell proliferation by deubiquitinating pyruvate kinase L/R in gallbladder cancer	6