Laboratory Investigation

Article	Citations
Artificial intelligence and computational pathology	239
PI3K-Akt-mTOR/PFKFB3 pathway mediated lung fibroblast aerobic glycolysis and collagen synthesis in lipopolysaccharide-induced pulmonary fibrosis	111
High-throughput proteomics: a methodological mini-review	87
Grading of adult diffuse gliomas according to the 2021 WHO Classification of Tumors of the Central Nervous System	77
Detection of SARS-CoV-2 in formalin-fixed paraffin-embedded tissue sections using commercially available reagents	74
Retrospective analysis of laboratory testing in 54 patients with severe- or critical-type 2019 novel coronavirus pneumonia	69
Adipose mesenchymal stem cell-derived exosomes accelerate skin wound healing via the lncRNA H19/miR-19b/SOX9 axis	62
Quantitative measurement of HER2 expression to subclassify ERBB2 unamplified breast cancer	55
Multiplexed ion beam imaging (MIBI) for characterization of the tumor microenvironment across tumor types	51
CCL3–CCR5 axis contributes to progression of esophageal squamous cell carcinoma by promoting cell migration and invasion via Akt and ERK pathways	46
N-methyladenosine reader YTHDF2-mediated long noncoding RNA FENDRR degradation promotes cell proliferation in endometrioid endometrial carcinoma	45
Deep learning shows the capability of high-level computer-aided diagnosis in malignant lymphoma	43
Vascular remodeling by placenta-derived mesenchymal stem cells restores ovarian function in ovariectomized rat model via the VEGF pathway	39
PAI-1 derived from cancer-associated fibroblasts in esophageal squamous cell carcinoma promotes the invasion of cancer cells and the migration of macrophages	37
Deep-learning-based accurate hepatic steatosis quantification for histological assessment of liver biopsies	37
Advancements in detection of SARS-CoV-2 infection for confronting COVID-19 pandemics	36
The lncRNA XIST/miR-150-5p/c-Fos axis regulates sepsis-induced myocardial injury via TXNIP-modulated pyroptosis	33
MicroRNA-182 improves spinal cord injury in mice by modulating apoptosis and the inflammatory response via IKKβ/NF-κB	33
Wolfram syndrome 1 gene regulates pathways maintaining beta-cell health and survival	32
Exosomal tau with seeding activity is released from Alzheimer's disease synapses, and seeding potential is associated with amyloid beta	32
Th17/IL-17 induces endothelial cell senescence via activation of NF-κB/p53/Rb signaling pathway	32
Fibronectin 1 activates WNT/β-catenin signaling to induce osteogenic differentiation via integrin β1 interaction	32
CircRNA-ST6GALNAC6 increases the sensitivity of bladder cancer cells to erastin-induced ferroptosis by regulating the HSPB1/P38 axis	31
Nicotinamide riboside, an NAD+ precursor, attenuates inflammation and oxidative stress by activating sirtuin 1 in alcohol-stimulated macrophages	31
miR-27a ameliorates chemoresistance of breast cancer cells by disruption of reactive oxygen species homeostasis and impairment of autophagy	31

Predictive modeling of estrogen receptor agonism, antagonism, and binding activities using machine- and deep-learning approaches	30
Brightfield multiplex immunohistochemistry with multispectral imaging	30
Exercise suppresses NLRP3 inflammasome activation in mice with diet-induced NASH: a plausible role of adropin	29
3′ MACE RNA-sequencing allows for transcriptome profiling in human tissue samples after long-term storage	29
Exosomes derived from hypoxic glioma deliver miR-1246 and miR-10b-5p to normoxic glioma cells to promote migration and invasion	29
LncRNA GAS5 activates the HIF1A/VEGF pathway by binding to TAF15 to promote wound healing in diabetic foot ulcers	28
Establishing a living biobank of patient-derived organoids of intraductal papillary mucinous neoplasms of the pancreas	28
Matrix metalloproteinase 11 (MMP11) in macrophages promotes the migration of HER2-positive breast cancer cells and monocyte recruitment through CCL2–CCR2 signaling	28
Hemoglobin oxidation generates globin-derived peptides in atherosclerotic lesions and intraventricular hemorrhage of the brain, provoking endothelial dysfunction	28
M1 macrophage-derived exosomes transfer miR-222 to induce bone marrow mesenchymal stem cell apoptosis	27
Curcumin attenuates Adriamycin-resistance of acute myeloid leukemia by inhibiting the lncRNA HOTAIR/miR-20a-5p/WT1 axis	27
Mechanical strain induces phenotypic changes in breast cancer cells and promotes immunosuppression in the tumor microenvironment	27
Pseudomonas aeruginosa virulence proteins pseudolysin and protease IV impede cutaneous wound healing	27
CircPAN3 ameliorates myocardial ischaemia/reperfusion injury by targeting miR-421/Pink1 axis-mediated autophagy suppression	27
TGFβ1-Smad canonical and -Erk noncanonical pathways participate in interleukin-17-induced epithelial–mesenchymal transition in Sjögren's syndrome	27
Myocardial tissue-specific Dnmt1 knockout in rats protects against pathological injury induced by Adriamycin	27
ECM1 secreted by HER2-overexpressing breast cancer cells promotes formation of a vascular niche accelerating cancer cell migration and invasion	26
Human urine-derived stem cell-derived exosomal miR-21-5p promotes neurogenesis to attenuate Rett syndrome via the EPha4/TEK axis	26
LncRNA XIST shuttled by adipose tissue-derived mesenchymal stem cell-derived extracellular vesicles suppresses myocardial pyroptosis in atrial fibrillation by disrupting miR-214-3p-mediated Arl2 inhib	26
Digital quantitative assessment of PD-L1 using digital spatial profiling	25
Quantitative assessment of inflammatory infiltrates in kidney transplant biopsies using multiplex tyramide signal amplification and deep learning	25
SPOCK1 overexpression induced by platelet-derived growth factor-BB promotes hepatic stellate cell activation and liver fibrosis through the integrin α5β1/PI3K/Akt signaling pathway	25
Kras mutation rate precisely orchestrates ductal derived pancreatic intraepithelial neoplasia and pancreatic cancer	24
Sporadic and Lynch syndrome-associated mismatch repair-deficient brain tumors	24
Deep learning-based grading of ductal carcinoma in situ in breast histopathology images	24
CD38 in cancer-associated fibroblasts promotes pro-tumoral activity	24
Enhanced alcoholic liver disease in mice with intestine-specific farnesoid X receptor deficiency	24
Hepatocyte-specific fibroblast growth factor 21 overexpression ameliorates high-fat diet-induced obesity and liver steatosis in mice	23
MiR-221-3p targets Hif-1α to inhibit angiogenesis in heart failure	23
Inhibition of miR-181a-5p reduces astrocyte and microglia activation and oxidative stress by activating SIRT1 in immature rats with epilepsy	22
Angiotensin-converting enzyme 2 influences pancreatic and renal function in diabetic mice	22
LncRNA SLCO4A1-AS1 modulates colon cancer stem cell properties by binding to miR-150-3p and positively regulating SLCO4A1	22
Extracellular vesicles derived from M2 microglia reduce ischemic brain injury through microRNA-135a-5p/TXNIP/NLRP3 axis	22
Bioglass promotes wound healing by inhibiting endothelial cell pyroptosis through regulation of the connexin 43/reactive oxygen species (ROS) signaling pathway	22
Distinct macrophage polarization in acute and chronic gout	21
A convolutional neural network model for survival prediction based on prognosis-related cascaded Wx feature selection	21
Characterization of COVID-19-associated cardiac injury: evidence for a multifactorial disease in an autopsy cohort	21
MiR-185-5p ameliorates endoplasmic reticulum stress and renal fibrosis by downregulation of ATF6	21
Large-scale, three-dimensional tissue cytometry of the human kidney: a complete and accessible pipeline	21
Performance and efficiency of machine learning algorithms for analyzing rectangular biomedical data	21
FABP4 activates the JAK2/STAT2 pathway via Rap1a in the homocysteine-induced macrophage inflammatory response in ApoE mice atherosclerosis	21
LncRNA MAPKAPK5_AS1 facilitates cell proliferation in hepatitis B virus -related hepatocellular carcinoma	21
Blocking thrombospondin-1 signaling via CD47 mitigates renal interstitial fibrosis	21
The HNRNPA2B1–MST1R–Akt axis contributes to epithelial-to-mesenchymal transition in head and neck cancer	21
Urinary ERdj3 and mesencephalic astrocyte-derived neutrophic factor identify endoplasmic reticulum stress in glomerular disease	21
Molecular signatures of tumor progression in myxoid liposarcoma identified by N-glycan mass spectrometry imaging	20
Crosstalk between progesterone receptor membrane component 1 and estrogen receptor α promotes breast cancer cell proliferation	20
Zyxin (ZYX) promotes invasion and acts as a biomarker for aggressive phenotypes of human glioblastoma multiforme	20
PCTR1 ameliorates lipopolysaccharide-induced acute inflammation and multiple organ damage via regulation of linoleic acid metabolism by promoting FADS1/FASDS2/ELOV2 expression and reducing PLA2 expres	20
The role of macrophage–fibroblast interaction in lipopolysaccharide-induced pulmonary fibrosis: an acceleration in lung fibroblast aerobic glycolysis	20

Characterization of pathological thyroid tissue using polarization-sensitive second harmonic generation microscopy	20
GestAltNet: aggregation and attention to improve deep learning of gestational age from placental whole-slide images	20
Extracellular cold-inducible RNA-binding protein regulates neutrophil extracellular trap formation and tissue damage in acute pancreatitis	20
Identification of differentially expressed genes in lung adenocarcinoma cells using single-cell RNA sequencing not detected using traditional RNA sequencing and microarray	20
Sustained hedgehog signaling in medulloblastoma tumoroids is attributed to stromal astrocytes and astrocyte-derived extracellular matrix	19
A mouse model for peritoneal metastases of colorectal origin recapitulates patient heterogeneity	19
Reproducible, high-dimensional imaging in archival human tissue by multiplexed ion beam imaging by time-of-flight (MIBI-TOF)	19
The antioxidative stress regulator Nrf2 potentiates radioresistance of oral squamous cell carcinoma accompanied with metabolic modulation	19
Overexpression of pigment epithelium-derived factor in placenta-derived mesenchymal stem cells promotes mitochondrial biogenesis in retinal cells	18
GTSE1 promotes prostate cancer cell proliferation via the SP1/FOXM1 signaling pathway	18
Accelerated instability testing reveals quantitative mass spectrometry overcomes specimen storage limitations associated with PD-L1 immunohistochemistry	18
Phospholipase Cγ1 (PLCG1) overexpression is associated with tumor growth and poor survival in IDH wild-type lower-grade gliomas in adult patients	18
Feline low-grade intestinal T cell lymphoma: a unique natural model of human indolent T cell lymphoproliferative disorder of the gastrointestinal tract	18
SIRT6 regulates SREBP1c-induced glucolipid metabolism in liver and pancreas via the AMPKα-mTORC1 pathway	18
The synthetic toxin biliatresone causes biliary atresia in mice	18
NFAT5 promotes oral squamous cell carcinoma progression in a hyperosmotic environment	17
Impairment of corneal epithelial wound healing is association with increased neutrophil infiltration and reactive oxygen species activation in tenascin X-deficient mice	17
MicroRNA-130b functions as an oncogene and is a predictive marker of poor prognosis in lung adenocarcinoma	17
Biliary damage and liver fibrosis are ameliorated in a novel mouse model lacking l-histidine decarboxylase/histamine signaling	17
Ubiquitin-specific protease 35 (USP35) mediates cisplatin-induced apoptosis by stabilizing BIRC3 in non-small cell lung cancer	17
Steatosis, inflammasome upregulation, and fibrosis are attenuated in miR-155 deficient mice in a high fat-cholesterol-sugar diet-induced model of NASH	17
Establishing standardized immune phenotyping of metastatic melanoma by digital pathology	17
Sox13 promotes hepatocellular carcinoma metastasis by transcriptionally activating Twist1	16
MiR-126-5p promotes contractile switching of aortic smooth muscle cells by targeting VEPH1 and alleviates Ang II-induced abdominal aortic aneurysm in mice	16
LncRNA SNHG5 upregulation induced by YY1 contributes to angiogenesis via miR-26b/CTGF/VEGFA axis in acute myelogenous leukemia	16
DNA methyltransferase 1 (DNMT1) suppresses mitophagy and aggravates heart failure via the microRNA-152-3p/ETS1/RhoH axis	16
IL-37bΔ1-45 suppresses the migration and invasion of endometrial cancer cells by targeting the Rac1/NF-κB/MMP2 signal pathway	16
βCysteine 93 in human hemoglobin: a gateway to oxidative stability in health and disease	16
Adipose tissue inflammation and systemic insulin resistance in mice with diet-induced obesity is possibly associated with disruption of PFKFB3 in hematopoietic cells	16
SECISBP2 is a novel prognostic predictor that regulates selenoproteins in diffuse large B-cell lymphoma	16
Mechanical loading activates the YAP/TAZ pathway and chemokine expression in the MLO-Y4 osteocyte-like cell line	15
Nuclear exclusion of YAP exacerbates podocyte apoptosis and disease progression in Adriamycin-induced focal segmental glomerulosclerosis	15
Loss of ephrin B2 receptor (EPHB2) sets lipid rheostat by regulating proteins DGAT1 and ATGL inducing lipid droplet storage in prostate cancer cells	15
Pretreatment with valproic acid alleviates pulmonary fibrosis through epithelial–mesenchymal transition inhibition in vitro and in vivo	15
Altered glycosylation of glycodelin in endometrial carcinoma	15
A novel image signature-based radiomics method to achieve precise diagnosis and prognostic stratification of gliomas	15
Aryl Hydrocarbon Receptor Activation Coordinates Mouse Small Intestinal Epithelial Cell Programming	15
miR-184 targets TP63 to block idiopathic pulmonary fibrosis by inhibiting proliferation and epithelial–mesenchymal transition of airway epithelial cells	15
MiR-200c-3p targets SESN1 and represses the IL-6/AKT loop to prevent cholangiocyte activation and cholestatic liver fibrosis	14
SMAD4 mutation correlates with poor prognosis in non-small cell lung cancer	14
6-Gingerol relieves myocardial ischaemia/reperfusion injury by regulating lncRNA H19/miR-143/ATG7 signaling axis-mediated autophagy	14
Parthenolide alleviates peritoneal fibrosis by inhibiting inflammation via the NF-κB/ TGF-β/Smad signaling axis	14
Reliability of liquid biopsy analysis: an inter-laboratory comparison of circulating tumor DNA extraction and sequencing with different platforms	14
Alternative activation of macrophages by prostacyclin synthase ameliorates alcohol induced liver injury	14
LncRNA UCC promotes epithelial–mesenchymal transition via the miR-143-3p/SOX5 axis in non-small-cell lung cancer	13
Generation of heterozygous PKD1 mutant pigs exhibiting early-onset renal cyst formation	13
Standardized Pathology Screening of Mature Tertiary Lymphoid Structures in Cancers	13
p53 Activates the Lipoxygenase Activity of ALOX15B via Inhibiting SLC7A11 to Induce Ferroptosis in Bladder Cancer Cells	13
Exploring photoacoustic spectroscopy-based machine learning together with metabolomics to assess breast tumor progression in a xenograft model ex vivo	13
Cholestasis impairs hepatic lipid storage via AMPK and CREB signaling in hepatitis B virus surface protein transgenic mice	13
EZH2 is associated with cartilage degeneration in osteoarthritis by promoting SDC1 expression via histone methylation of the microRNA-138 promoter	13
MicroRNA-432-5p regulates sprouting and intussusceptive angiogenesis in osteosarcoma microenvironment by targeting PDGFB	12
TRIM27 contributes to glomerular endothelial cell injury in lupus nephritis by mediating the FoxO1 signaling pathway	12
Predicting 1p/19q co-deletion status from magnetic resonance imaging using deep learning in adult-type diffuse lower-grade gliomas: a discovery and validation study	12
Hepatitis B virus core protein promotes the expression of neuraminidase 1 to facilitate hepatocarcinogenesis	12
Inhibitory effects of temozolomide on glioma cells is sensitized by RSL3-induced ferroptosis but negatively correlated with expression of ferritin heavy chain 1 and ferritin light chain	12
Anti-tumor effects of vitamin D in glioblastoma: mechanism and therapeutic implications	12
Silencing of LINC01963 enhances the chemosensitivity of prostate cancer cells to docetaxel by targeting the miR-216b-5p/TrkB axis	12
Deepfake Histologic Images for Enhancing Digital Pathology	12
CircN4BP2L2 promotes colorectal cancer growth and metastasis through regulation of the miR-340-5p/CXCR4 axis	12
αTAT1-induced tubulin acetylation promotes ameloblastoma migration and invasion	12
Circulating tumor DNA profiling for childhood brain tumors: Technical challenges and evidence for utility	12
Distinct transcriptional programs of SOX2 in different types of small cell lung cancers	11
Generation of a new immortalized human lung pericyte cell line: a promising tool for human lung pericyte studies	11
The transient receptor potential vanilloid 4 (TRPV4) ion channel mediates protease activated receptor 1 (PAR1)-induced vascular hyperpermeability	11
Amelioration of circadian disruption and calcium-handling protein defects by choline alleviates cardiac remodeling in abdominal aorta coarctation rats	11
Long noncoding Mirt2 reduces apoptosis to alleviate myocardial infarction through regulation of the miR-764/PDK1 axis	11
Early pathogenesis of cystic fibrosis gallbladder disease in a porcine model	11
lncRNA NEAT1 aggravates sepsis-induced lung injury by regulating the miR-27a/PTEN axis	11
Ascorbate-induced oxidative stress mediates TRP channel activation and cytotoxicity in human etoposide-sensitive and -resistant retinoblastoma cells	11
PLODs are overexpressed in ovarian cancer and are associated with gap junctions via connexin 43	11
A MXI1-NUTM1 fusion protein with MYC-like activity suggests a novel oncogenic mechanism in a subset of NUTM1-rearranged tumors	11
Long non-coding RNA MALAT1 enhances angiogenesis during bone regeneration by regulating the miR-494/SP1 axis	11
Monomeric C reactive protein (mCRP) regulates inflammatory responses in human and mouse chondrocytes	11
Morphological changes in synovial mesenchymal stem cells during their adhesion to the meniscus	11
LncRNA SNHG15 relieves hyperglycemia-induced endothelial dysfunction via increased ubiquitination of thioredoxin-interacting protein	11
Conventional histological and cytological staining with simultaneous immunohistochemistry enabled by invisible chromogens	11
Assessing the utility of long-read nanopore sequencing for rapid and efficient characterization of mobile element insertions	10
AccuCor2: isotope natural abundance correction for dual-isotope tracer experiments	10
LncRNA ROR modulates myocardial ischemia-reperfusion injury mediated by the miR-185-5p/CDK6 axis	10

Vasoinhibin reduces joint inflammation, bone loss, and the angiogenesis and vasopermeability of the pannus in murine antigen-induced arthritis	10
Inhibition of syndecan-4 reduces cartilage degradation in murine models of osteoarthritis through the downregulation of HIF-2α by miR-96-5p	10
A generative adversarial approach to facilitate archival-quality histopathologic diagnoses from frozen tissue sections	10
Bone morphogenetic protein induces bone invasion of melanoma by epithelial–mesenchymal transition via the Smad1/5 signaling pathway	10
GTSE1 promotes tumor growth and metastasis by attenuating of KLF4 expression in clear cell renal cell carcinoma	10
LINC01419-mediated epigenetic silencing of ZIC1 promotes metastasis in hepatocellular carcinoma through the PI3K/Akt signaling pathway	10
Resveratrol promotes skin wound healing by regulating the miR-212/CASP8 axis	10
Genetic loss-of-function of activating transcription factor 3 but not C-type lectin member 5A prevents diabetic peripheral neuropathy	10
Early response in phosphorylation of ribosomal protein S6 is associated with sensitivity to trametinib in colorectal cancer cells	10
A new technological approach in diagnostic pathology: mass spectrometry imaging-based metabolomics for biomarker detection in urachal cancer	10
Evaluation of an EZH2 inhibitor in patient-derived orthotopic xenograft models of pediatric brain tumors alone and in combination with chemo- and radiation therapies	10
Exosomes derived from hypoxia-induced alveolar epithelial cells stimulate interstitial pulmonary fibrosis through a HOTAIRM1-dependent mechanism	10
Dissection of PD-L1 promoter reveals differential transcriptional regulation of PD-L1 in VHL mutant clear cell renal cell carcinoma	10
Novel role of the dietary flavonoid fisetin in suppressing rRNA biogenesis	10
A novel human endometrial epithelial cell line for modeling gynecological diseases and for drug screening	10
Pigs with δ-sarcoglycan deficiency exhibit traits of genetic cardiomyopathy	10
Analysis of DNA variants in miRNAs and miRNA 3ʼUTR binding sites in female infertility patients	10
Serotonin-induced vascular permeability is mediated by transient receptor potential vanilloid 4 in the airways and upper gastrointestinal tract of mice	9
Osr1 regulates hepatic inflammation and cell survival in the progression of non-alcoholic fatty liver disease	9
Reversal of hypertriglyceridemia in diabetic BTBR ob/ob mice does not prevent nephropathy	9
Protein-based immune profiles of basal-like vs. luminal breast cancers	9
circHECTD1 attenuates apoptosis of alveolar epithelial cells in acute lung injury	9
CP-25 alleviates antigen-induced experimental Sjögren's syndrome in mice by inhibiting JAK1-STAT1/2-CXCL13 signaling and interfering with B-cell migration	9
ZKSCAN3 in severe bacterial lung infection and sepsis-induced immunosuppression	9
5-HT7 receptor-dependent intestinal neurite outgrowth contributes to visceral hypersensitivity in irritable bowel syndrome	9
Induction of cancer cell stemness in glioma through glycolysis and the long noncoding RNA HULC-activated FOXM1/AGR2/HIF-1α axis	9
Pharmacological inhibition of serine synthesis enhances temozolomide efficacy by decreasing O6-methylguanine DNA methyltransferase (MGMT) expression and reactive oxygen species (ROS)-mediated DNA dama	9
Multimetric feature selection for analyzing multicategory outcomes of colorectal cancer: random forest and multinomial logistic regression models	9
Development of an immunohistochemical assay for Siglec-15	9
A time-course Raman spectroscopic analysis of spontaneous in vitro microcalcifications in a breast cancer cell line	9
MicroRNA-483-5p accentuates cisplatin-induced acute kidney injury by targeting GPX3	9
Interpretable tumor differentiation grade and microsatellite instability recognition in gastric cancer using deep learning	9
Characterization of colorectal mucus using infrared spectroscopy: a potential target for bowel cancer screening and diagnosis	9
Commensal gut bacterium critically regulates alveolar bone homeostasis	9
An active learning approach for clustering single-cell RNA-seq data	8
Surfactant protein A modulates the activities of the JAK/STAT pathway in suppressing Th1 and Th17 polarization in murine OVA-induced allergic asthma	8
Cell-free plasma microRNAs that identify patients with glioblastoma	8
NLRP3 deficiency did not attenuate NASH development under high fat calorie diet plus high fructose and glucose in drinking water	8
CpG-SNP site methylation regulates allele-specific expression of MTHFD1 gene in type 2 diabetes	8
Deficiency of C-X-C chemokine receptor type 5 (CXCR5) gene causes dysfunction of retinal pigment epithelium cells	8
Upregulation of KLHL17 promotes the proliferation and migration of non-small cell lung cancer by activating the Ras/MAPK signaling pathway	8
A soluble endoplasmic reticulum factor as regenerative therapy for Wolfram syndrome	8
Nitric oxide-targeted therapy inhibits stemness and increases the efficacy of tamoxifen in estrogen receptor-positive breast cancer cells	8
Bone mesenchymal stem cell-derived extracellular vesicles containing NORAD promote osteosarcoma by miR-30c-5p	8
A novel tree shrew model of pulmonary fibrosis	8
Advanced detection strategies for cardiotropic virus infection in a cohort study of heart failure patients	8
Nuclear receptor binding factor 2 (NRBF2) is required for learning and memory	8
DDAH-1, via regulation of ADMA levels, protects against ischemia-induced blood-brain barrier leakage	8
Loss of sphingosine 1-phosphate receptor 3 gene function impairs injury-induced stromal angiogenesis in mouse cornea	8
Clinical implications of exosome-derived noncoding RNAs in liver	8
Programmed death-1 promotes contused skeletal muscle regeneration by regulating Treg cells and macrophages	8
Photoactivatable Cre knock-in mice for spatiotemporal control of genetic engineering in vivo	8
Real-time lipid patterns to classify viable and necrotic liver tumors	8
Unstained Tissue Imaging and Virtual Hematoxylin and Eosin Staining of Histologic Whole Slide Images	8
Quantitative analysis of abnormalities in gynecologic cytopathology with deep learning	8
ATF-3 expression inhibits melanoma growth by downregulating ERK and AKT pathways	8
Stress can attenuate hepatic lipid accumulation via elevation of hepatic β-muricholic acid levels in mice with nonalcoholic steatohepatitis	8
Vitamin E relieves chronic obstructive pulmonary disease by inhibiting COX2-mediated p-STAT3 nuclear translocation through the EGFR/MAPK signaling pathway	8
L-carnitine suppresses transient receptor potential vanilloid type 1 activity and myofibroblast transdifferentiation in human corneal keratocytes	8
Extracellular vesicles derived from miR-199a-5p-modified adipose-derived mesenchymal stem cells alleviate immune thrombocytopenia by inhibiting T helper 17 differentiation	8
Digitization of Pathology Labs: A Review of Lessons Learned	8
Tubeimoside I improves endothelial function in sepsis via activation of SIRT3	7
Retinoblastoma tumor cell proliferation is negatively associated with an immune gene expression signature and increased immune cells	7
Potential role for EZH2 in promotion of asthma through suppression of miR-34b transcription by inhibition of FOXO3	7
Inhibition of TXNDC5 attenuates lipopolysaccharide-induced septic shock by altering inflammatory responses	7
Phenotyping clonal populations of glioma stem cell reveals a high degree of plasticity in response to changes of microenvironment	7
Increased talin–vinculin spatial proximities in livers in response to spotted fever group rickettsial and Ebola virus infections	7
Establishing the ground squirrel as a superb model for retinal ganglion cell disorders and optic neuropathies	7
SLUG is a key regulator of epithelial-mesenchymal transition in pleomorphic adenoma	7
ASIC1a promotes the proliferation of synovial fibroblasts via the ERK/MAPK pathway	7
Synergistic upregulation of ADAMTS4 (aggrecanase-1) by cytokines and its suppression in knee osteoarthritic synovial fibroblasts	7
Advances in neuroendocrine prostate cancer research: From model construction to molecular network analyses	7
Experimental models of undifferentiated pleomorphic sarcoma and malignant peripheral nerve sheath tumor	7
Fibroblast growth factor 21, a stress regulator, inhibits Drp1 activation to alleviate skeletal muscle ischemia/reperfusion injury	7
Nesfatin-1 exerts protective effects on acidosis-stimulated chondrocytes and rats with adjuvant-induced arthritis by inhibiting ASIC1a expression	7
The MFF-SIRT1/3 axis, regulated by miR-340-5p, restores mitochondrial homeostasis of hypoxia-induced pulmonary artery smooth muscle cells	7
High levels of TIMP1 are associated with increased extracellular matrix stiffness in isocitrate dehydrogenase 1-wild type gliomas	7
Diagnosis of Alzheimer Disease and Tauopathies on Whole-Slide Histopathology Images Using a Weakly Supervised Deep Learning Algorithm	7
Histone H2B induces retinal ganglion cell death through toll-like receptor 4 in the vitreous of acute primary angle closure patients	7
Elk-1 transcriptionally regulates ZC3H4 expression to promote silica-induced epithelial–mesenchymal transition	7
PAQR3 depletion accelerates diabetic wound healing by promoting angiogenesis through inhibiting STUB1-mediated PPARγ degradation	6
PCP4/PEP19 downregulates neurite outgrowth via transcriptional regulation of Ascl1 and NeuroD1 expression in human neuroblastoma M17 cells	6
Pathophysiological mechanisms underlying a rat model of triple whammy acute kidney injury	6
MicroRNA-26a-5p Restoration Ameliorates Unilateral Ureteral Obstruction-Induced Renal Fibrosis in Mice Through Modulating TGF-β Signaling	6
Overexpression of carnitine palmitoyltransferase 1A promotes mitochondrial fusion and differentiation of glioblastoma stem cells	6
The N6-methyladenosine writer WTAP contributes to the induction of immune tolerance post kidney transplantation by targeting regulatory T cells	6
PHLDA3 promotes lung adenocarcinoma cell proliferation and invasion via activation of the Wnt signaling pathway	6
Utilizing tandem mass spectrometry for metabolic flux analysis	6
Simultaneous metabolite MALDI-MSI, whole exome and transcriptome analysis from formalin-fixed paraffin-embedded tissue sections	6
Increased chemosensitivity via BRCA2-independent DNA damage in DSS1- and PCID2-depleted breast carcinomas	6
Quantitative 3-dimensional imaging and tissue cytometry reveals lymphatic expansion in acute kidney injury	6
An improved assay for detection of theranostic gene translocations and MET exon 14 skipping in thoracic oncology	6
Deep convolutional neural network-based algorithm for muscle biopsy diagnosis	6
Ubiquitin-specific protease 3 facilitates cell proliferation by deubiquitinating pyruvate kinase L/R in gallbladder cancer	6
RNA adenosine deaminase (ADAR1) alleviates high-fat diet-induced nonalcoholic fatty liver disease by inhibiting NLRP3 inflammasome	6