Journal of Physiology-London

Article	Citations
Issue Information	190
Integrating respiration into sympathetic transduction to blood pressure	85
Issue Information	80
In Memoriam: Ann Silver	66
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Issue Information	63
Motor learning changes the axon initial segment of the spinal motoneuron	60
CrossTalk rebuttal	58
Determinants and therapeutic potential of calcium handling abnormalities in atrial fibrillation: what can we learn from computer models?	57
Decoding platelet loss in the hypoxic brain: What could go wrong?	54
Goal‐directed action preparation in humans entails a mixture of corticospinal neural computations	53
Augmenting workload drives T‐tubule assembly in developing cardiomyocytes	53
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Changes in intra‐ and interlimb reflexes from forelimb cutaneous afferents after staggered thoracic lateral hemisections during locomotion in cats	49
Bayliss–Starling Prize Lecture: KATP channel pathophysiology – a whole‐body odyssey	45
The 70‐year search for the voltage‐sensing mechanism of ion channels	44
Diarrhoeal pathogenesis in Salmonella infection may result from an imbalance in intestinal epithelial differentiation through reduced Notch signalling	44
Severe hypoxaemic hypercapnia compounds cerebral oxidative–nitrosative stress during extreme apnoea: Implications for cerebral bioenergetic function	43
CKAMP44 controls synaptic function and strength of relay neurons during early development of the dorsal lateral geniculate nucleus	43
Can heat stress augment the cerebrovascular and neurotrophic benefits of exercise?	42
Mitochondrial haplotype and sex modulate responses to endurance exercise training	41
Peripheral chemoreflex restrains skeletal muscle blood flow during exercise in participants with treated hypertension	41
Stroke severity shapes extracellular vesicle profiles and their impact on the cerebral endothelial cells	41
‘Evolutionary poker’: an agent‐based model of interactome emergence and epistasis tested against Lenski's long‐term E. coli experiments	40
High‐frequency electrical tuning and linear filter properties of Knollenorgan electroreceptors of mormyrid electric fish	40

The ups and downs of intermittent hypoxia as a therapy for ventilatory insufficiency	39
Opening the door to physiological impacts underlying opioid‐induced respiratory depression and therapeutic strategies: focus on fentanyl	39
Reply to ‘Reevaluating central versus peripheral contributions to maximal oxygen uptake: the role of muscle diffusive capacity’	38
Activation of the myosin motors in fast‐twitch muscle of the mouse is controlled by mechano‐sensing in the myosin filaments	38
Unveiling sex differences in skeletal muscle metabolism: the role of HIF1α in normoxia	38
Action potentials in postganglionic sympathetic nerves depend on NaV1.7	38
Cerebral uptake of microvesicles occurs in normocapnic but not hypocapnic passive hyperthermia in young healthy male adults	37
The endocrine kidney: tampering with oxygen sensors may change your character	37
The astrocytic Na+‐HCO3− cotransporter, NBCe1, is dispensable for respiratory chemosensitivity	37
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Why you should pay more attention to your cells’ sex	36
Ventricular arrhythmogenic remodelling in diet‐induced metabolic syndrome driven by right‐to‐left regional differences in action potential duration and dominant frequency gradients	36
Ocular surface information seen from the somatosensory thalamus and cortex	35
Theoretical analysis of power‐law stress relaxation and calcium‐dependent passive mechanics in cardiac muscle	34
The impact of androgens on cardiovascular control mechanisms in polycystic ovary syndrome: Recent advances and translational approaches	34
Hypertension increases sympathetic neuron activity by enhancing intraganglionic cholinergic collateral connections	34
Nitric oxide synthase inhibition in healthy adults reduces regional and total cerebral macrovascular blood flow and microvascular perfusion	34
Maternal obesity alters myeloid immune function in the offspring	33
Uncertainty quantification via polynomial chaos expansion of myocardial fibre orientation and cardiac activation patterns	33
Corticothalamic modulation of somatosensory thalamic tactile processing	33
Pregnancy does not affect progression of mild experimental asthma in sheep	33
Heartbeat‐related activity in the anterior thalamus differs between phasic and tonic REM sleep	33
Sensorimotor integration within the primary motor cortex by selective nerve fascicle stimulation	32
Diversity of cells and signals in the cardiovascular system	32
Mitochondrial carbonic anhydrase VA and VB: properties and roles in health and disease	32
Chronic intermittent hypoxia‐induced cardiovascular and renal dysfunction: from adaptation to maladaptation	32
Lack of compensatory mitophagy in skeletal muscles during sepsis	32
Magnesium sulphate reduces tertiary gliosis but does not improve EEG recovery or white or grey matter cell survival after asphyxia in preterm fetal sheep	31
Engineering the immune and fibrotic response in VML	31
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An experiment of nature links muscle glycogen unavailability with very high fat oxidation rates despite low aerobic fitness	30
Macrophage microvesicle‐derived circ_YTHDF2 in methamphetamine‐induced chronic lung injury	29
Issue Information	29
Hypoxic sensitivity and burden predict propensity for respiratory plasticity in humans	29
Want to hear ClC‐6 sing? Push your amp to eleven	29
Response to ‘Comment on Wyrwoll et al., 2022: Long‐term exposure of mice to 890 ppm atmospheric CO2 alters growth trajectories and hyperactive behaviours in adults’ by Norman R. Saunders an	29
Speciation by physiological selection of environmentally acquired traits	28
Bioavailable testosterone and androgen receptor activation, but not total testosterone, are associated with muscle mass and strength in females	28
The fallacy of functional nomenclature in the kingdom of biological multifunctionality: physiological and evolutionary considerations on ion channels	28
The potential therapeutic benefits of low frequency haemodynamic oscillations	28
Insulin potentiates the response to capsaicin in dorsal root ganglion neurons in vitro and muscle afferents ex vivo in normal healthy rodents	28
Extracellular vesicles and their non‐coding RNA cargos: Emerging players in cardiovascular disease	28
Muscle déjà vu: are myonuclei the blueprint for muscle regrowth?	27
Corrigendum	27
Glucocorticoids regulate mitochondrial fatty acid oxidation in fetal cardiomyocytes	26
Multi‐scale modelling of the effects of ageing, hypertension and exercise on the cerebral vasculature	26
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The neural control of movement: a century of in vivo motor unit recordings is the legacy of Adrian and Bronk	26

Synaptic loss in motor neurons precipitates age‐related dysphagia: Middle agers gotta keep in touch!	26
Optical mapping of contracting hearts	26
Issue Information	26
Advances in cardiac devices and bioelectronics augmented with artificial intelligence	26
Efficiency of cycling exercise: Understanding the physiology	25
Sexual dimorphism: increased sterol excretion leads to hypocholesterolaemia in female hyperbilirubinaemic Gunn rats	25
Too hot to handle? Unveiling gut permeability during exertional heat stress	25
Making ‘sense’ of what happens on the inside: il‘LUMEN'ating the effects of intestinal distention on calcium activity in enteric neurons	25
Loss of the alpha subunit distal furin cleavage site blunts ENaC activation following Na+ restriction	25
Release your inhibitions: The role of post‐inhibitory rebound and synaptic inhibition in the generation of expiratory activity	25
Situating physiology within evolutionary theory	24
Muscle matters: exploring the contributions of ageing skeletal muscle to metabolic syndrome	24
Action potential amplitude and baroreflex resetting of action potential clusters mediate hypoxia‐induced sympathetic long‐term facilitation	24
The non‐invasive assessment of muscle fibre size: has the future arrived?	24
Multispectral brain connectivity during visual attention distinguishes controlled from uncontrolled hypertension	24
Muscle memory theory: Implications for health, athletic performance and sports integrity	24
Towards unravelling the exercise‐induced adaptations in circulating extracellular vesicles	24
Reply from D. R. Perkins and Mike Stembridge	24
Presynaptic H3 receptor: A modulator for CeL excitatory‐inhibitory homeostasis	23
Thermodynamic limitations on brain oxygen metabolism: physiological implications*	23
A cross‐species validation of single‐beat metrics of cardiac contractility	23
Microglial phagocytosis in epilepsy: Mechanisms and impact	23
Properties and modulation of excitatory inputs to the locus coeruleus	23
Volitional exercise elicits physiological and molecular improvements in the severe D2.mdx mouse model of Duchenne muscular dystrophy	23
Dietary nitrate supplementation improves age‐associated neuromuscular outcomes: A step towards healthy ageing	23
Cathodal bilateral transcranial direct‐current stimulation regulates selenium to confer neuroprotection after rat cerebral ischaemia–reperfusion injury	23
Inflammatory gene expression during acute high‐altitude exposure	22
Issue Information	22
The pathological blood flow steal phenomenon limits exercise tolerance in pulmonary hypertensive rats	22
Ageing reduces persistent inward current contribution to motor neurone firing: Potential mechanisms and the role of exercise	22
The diverse functions of the DEG/ENaC family: linking genetic and physiological insights	22
The key to our hearts: Unlocking fundamental sex differences in mouse cardiomyocyte calcium‐cycling	22
Central α2‐adrenergic mechanisms regulate human sympathetic neuronal discharge strategies	22
Issue Information	22
From signals to systems: Mapping the complex physiology of cardiorespiratory dynamics with information theory	22
Fast and sensitive GCaMP calcium indicators for neuronal imaging	22
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Flex and flow: are we receptive to all females in muscle physiology research?	22
Hyperglycaemia, pregnancy outcomes and maternal metabolic disease risk during pregnancy and lactation in a lean gestational diabetes mouse model	22
Use it or lose it: protecting ageing muscles with lifelong recreational exercise	21
Adenine nucleotide translocator and ATP synthase cooperate in mediating the mitochondrial permeability transition	21
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Ketogenic diet and ketone salts differentially improve cardiometabolic complications in an HFpEF rat model	21
A systematic review of computational models for the design of spinal cord stimulation therapies: from neural circuits to patient‐specific simulations	21
Issue Information	21
Muscular strength, endothelial function and cognitive disorders: state of the art	21
Exercise intolerance in pulmonary hypertension: robbing Peter to pay Paul	21
The time is now: regular exercise maintains vascular health in ageing women	21
The complexity of Nrf2 in experimental autoimmune myositis‐induced mice	20
Hydrogen peroxide and phosphoinositide metabolites synergistically regulate a cation current to influence neuroendocrine cell bursting	20
Critical molecular outcomes of time‐restricted feeding during ageing: a look beyond body composition	20
Adrenergic restraint of blood flow and high‐altitude acclimatization	20
Whole‐body metabolic rate is influenced by muscle fibre typology	20
Pathogenic TNNT1 variants are associated with aberrant thin filament compliance and myofibre hyper‐contractility	20
Circadian patterns of heart rate variability in fetal sheep after hypoxia‐ischaemia: A biomarker of evolving brain injury	20
Something's fishy: cardiovascular ATP‐sensitive K+ channels in zebrafish	19
CPT1C is required for synaptic plasticity and oscillatory activity that supports motor, associative and non‐associative learning	19
Intrinsic motoneuron properties in typical human development	19
An automated respiratory data pipeline for waveform characteristic analysis	19
Who's on first … Na+, HCO3− or CO32−?	19
Past questions, present results, future perspectives: Interacting chemosensitive areas and the hypercapnic ventilatory response	19
A game of chest: Where does blood volume shift?	19
Towards spatially selective efferent neuromodulation: anatomical and functional organization of cardiac fibres in the porcine cervical vagus nerve	19
Reduced plakoglobin increases the risk of sodium current defects and atrial conduction abnormalities in response to androgenic anabolic steroid abuse	19
Maternal sleep behaviours preceding fetal heart rate events on cardiotocography	19
Function of K2P channels in the mammalian node of Ranvier	19
Particle‐swarm based modelling reveals two distinct classes of CRHPVN neurons	19
Characterizing the effects of type I collagen alterations on respiratory function in mouse models with varying severity of osteogenesis imperfecta	19
Nav1.2 and BK channel interaction shapes the action potential in the axon initial segment	19
Crosstalk between biochemical signalling network architecture and trafficking governs AMPAR dynamics in synaptic plasticity	19
Mechano‐electrical interactions and heterogeneities in wild‐type and drug‐induced long QT syndrome rabbits	19
Pump up the volume: breathing facilitates cardiac output during exercise by mechanical action	19
Ageing impairs endothelium‐dependent vasodilatation and alters redox signalling in diaphragm arterioles from male and female Fischer‐344 rats	18
Neurobiology of mitochondrial dynamics in sleep	18
Novel regenerative drug, SPG302 promotes functional recovery of diaphragm muscle activity after cervical spinal cord injury	18
The post‐arteriole transitional zone: a specialized capillary region that regulates blood flow within the CNS microvasculature	18
Metabolite‐sensitive cross‐bridge models of human atria reveal the impact of diabetes on muscle mechanoenergetics	18
The effects of local vibration inducing a tonic vibration reflex or movement illusion on acute modulations of corticospinal excitability	18
The cardiac sodium channel from function to dysfunction	18
TET2 confers a mechanistic link of microRNA‐210 and mtROS in hypoxia‐suppressed spontaneous transient outward currents in uterine arteries of pregnant sheep	18

Glyoxalase 1 overexpression improves neurovascular coupling and limits development of mild cognitive impairment in a mouse model of type 1 diabetes	18
Neuroinflammation and the immune system in hypoxic ischaemic brain injury pathophysiology after cardiac arrest	18
Beeting atrophy: dietary nitrate to protect the powerhouse of the cell?	18
Translating physiology of the arterial chemoreflex into novel therapeutic interventions targeting carotid bodies in cardiometabolic disorders	18
Reorganization of mitochondria–organelle interactions during postnatal development in skeletal muscle	18
Astrocytes: Orchestrators of brain gas exchange and oxygen homeostasis	18
Identification of a helix–turn–helix motif for high temperature dependence of vanilloid receptor TRPV2	18
Exosomes and the cardiovascular system: role in cardiovascular health and disease	18
A detailed mathematical model of the human atrial cardiomyocyte: integration of electrophysiology and cardiomechanics	18
Enter Sandman: An eye opening opinion of cardiovascular disease prevention in cervical spinal cord injury	17
Scale‐invariant changes in corticospinal excitability reflect multiplexed oscillations in the motor output	17
Insulin, Nobel laureates and The Journal of Physiology	17
Endurance exercise training changes the limitation on muscle V̇O2max${\dot{V}}_{{{\mathrm{O}}}_{\mathrm{2}}{\mathrm{max}}}$ in normoxia from the capacity to utilize O2 to the capacity to tr	17
Issue Information	17
Profoundly lower muscle mass and rate of contractile protein synthesis in boys with Duchenne muscular dystrophy	17
Rebuttal from Amy Richardson and Gareth Morris	17
Beyond the madness: a balanced approach to standardization, practicality and innovation in exercise physiology threshold assessment	17
Exercise affects fatty acid oxidation and lipid droplets in patients with type 2 diabetes	17
Oncomodulin regulates spontaneous calcium signalling and maturation of afferent innervation in cochlear outer hair cells	17
Issue Information	17
Notch1 promotes ordered revascularization through Semaphorin 3g modulation of downstream vascular patterning signalling factors	17
Muscle–fat crosstalk: effects of exercise on brown adipose tissue; what do we know?	17
Vaping for two: unravelling the mysteries of E‐cigarettes and fetal vascular health	17
Cross Talk proposal: Human‐derived brain tissue is a better epilepsy model than animal‐based approaches	17
Issue Information	17
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Comparison of excitation–contraction coupling between Drosophila and vertebrate muscle	16
Untangling age and menopause: vascular mechanisms for cardiovascular disease risk in females	16
Expiratory flow limitation during exercise: why does it ‘suck’ so much?	16
Recurrence of ventricular fibrillation in out‐of‐hospital cardiac arrest: Clinical evidence and underlying ionic mechanisms	16
Cardiac programming in the placentally restricted sheep fetus in early gestation	16
When right ventricular pressure meets volume: The impact of arrival time of reflected waves on right ventricle load in pulmonary arterial hypertension	16
Ca2+ signalling in interstitial cells of Cajal contributes to generation and maintenance of tone in mouse and monkey lower oesophageal sphincters	16
Becoming mindful of mindfulness: a promising approach to reducing sympathetic nervous system overactivity in chronic kidney disease	16
Muscle‐derived IL‐1β regulates EcSOD expression via the NBR1‐p62‐Nrf2 pathway in muscle during cancer cachexia	16
Annual Prize Lecture 2024: Endogenous physiological mechanisms as basis for the treatment of obesity and type 2 diabetes	16
Fluorescent biosensor imaging meets deterministic mathematical modelling: quantitative investigation of signalling compartmentalization	16
Time course and fibre type‐dependent nature of calcium‐handling protein responses to sprint interval exercise in human skeletal muscle	16
Loss of anoctamin 1 reveals a subtle role for BK channels in lymphatic muscle action potentials	16
Age‐related diaphragm dysfunction: could diaphragm arteriole dysfunction be to blame?	16
Can muscle typology explain the inter‐individual variability in resistance training adaptations?	16
Fasting and the short‐term consumption of a ketogenic diet are sufficient interventions to protect against OLZ‐induced hyperglycaemia in mice	16
The legacy of A. V. Hill's Nobel Prize winning work on muscle energetics	16
Symptom‐modifying strategy to treat upper respiratory tract infections: a clinical and mechanistic evidence of ColdZyme	16
What is fetal growth restriction and how might we know?	16
Plasma measurements of the dual sugar test reveal carbohydrate immediately alleviates intestinal permeability caused by exertional heat stress	15
The complex function of macrophages and their subpopulations in metabolic injury associated fatty liver disease	15
Paraventricular nucleus projections to the nucleus tractus solitarii are essential for full expression of hypoxia‐induced peripheral chemoreflex responses	15
Evolution of rod bipolar cells and rod vision	15
Presynaptic quantal size enhancement counteracts post‐tetanic release depression	15
Mitochondrial function in brain and muscle metabolism: the crucial role during early sensorimotor development	15
Deficiency of PKA‐mediated SNAP‐25b phosphorylation destabilizes exocytotic fusion pores and reduces the interactions of t‐SNAREs	15
A multimodal exercise countermeasure prevents the negative impact of head‐down tilt bed rest on muscle volume and mitochondrial health in older adults	15
Physiological mechanisms of unexplained (functional) gastrointestinal disorders	15
Ageing‐induced weakness of mouse NMJs is associated with reduced active zone density, synaptic event kinetics and presynaptic calcium entry	15
Ubiquitin ligase signalling networks shape presynaptic development, function and disease	15
Activation of TRPA1 and TRPM3 triggers Ca2+ waves in central terminals of sensory neurons and facilitates synaptic activity in the spinal dorsal horn	15
Neural coordination of bilateral hand movements: evidence for an involvement of brainstem motor centres	15
Directional sensitivity of C‐low‐threshold mechanoreceptors: insights from in vivo calcium imaging	15
Interstitial cells of Cajal – pacemakers of the gastrointestinal tract	15
Oxytocin and corticotropin‐releasing hormone exaggerate nucleus tractus solitarii neuronal and synaptic activity following chronic intermittent hypoxia	15
Enhancing stroke risk stratification in atrial fibrillation through non‐Newtonian blood modelling and Gaussian process emulation	15
Stem cell approaches for tendon repair: delusion or insight	15
The repair capacity spectrum of human skeletal muscle injury from sports to surgical trauma settings	15
Phase‐dependent local brain states determine the impact of image‐guided transcranial magnetic stimulation on motor network electroencephalographic synchronization	15
The association between pain‐induced autonomic reactivity and descending pain control is mediated by the periaqueductal grey	14
Extracellular vesicles and their microRNA cargo in ischaemic stroke	14
High altitude differentially modulates potassium channel‐evoked vasodilatation in pregnant human myometrial arteries	14
Transient capacitance changes recorded from vestibular type I hair cells are produced by GK,L gating and do not involve neurotransmitter exocytosis	14
Correction to ‘A single bout of prior resistance exercise attenuates muscle atrophy and declines in myofibrillar protein synthesis during bed‐rest in older men’	14
Autonomic modulation with mindfulness‐based stress reduction in chronic kidney disease: a randomized controlled trial	14
A narrative review of periodic breathing during sleep at high altitude: From acclimatizing lowlanders to adapted highlanders	14
Pedalling toward a deeper understanding of exercise effects on immune function	14
School of ‘hard NOX’ for the ageing artery	14
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Pancreatic acinar cell signalling and function exhibit an absolute requirement for activation of Gαq	14
Blebbistatin reduces calcium buffering in cardiomyocytes: Consequences for cellular electrophysiology	14
Now and then: Development of spinal Shox2 neurons	14
Channelling protons out of the heart	14
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BK channels at dendritic spines: A mechanism for coupling morphology, plasticity and information storage?	14
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Homeostasis and evolution in relation to regeneration and repair	14
State‐dependent neural representations of muscle synergies in the spinal cord revealed by optogenetic stimulation	14
Stepping up to inspire in muscular dystrophy	14
Chemoreflex function in pulmonary diseases – A review	14
Exercise, healthy ageing, and the potential role of small extracellular vesicles	14
Issue Information	14
Mutation protocols share with sexual reproduction the physiological role of producing genetic variation within ‘constraints that deconstrain’	13
Mitochondrial calcium: An essential element for skeletal muscle performance and function	13
Comprehensive measurement of muscle maximal oxygen uptake determinants: insights and application	13
Skeletal muscle mitochondria in strength athletes: meeting energy needs with mitochondrial morphological changes	13
Active force generation contributes to the complexity of spontaneous activity and to the response to stretch of murine cardiomyocyte cultures	13
Using exercise training to improve glycaemic control and uncover mechanisms of impaired skeletal muscle in type 1 diabetics	13