Journal of Physiology-London

Article	Citations
Issue Information	215
Issue Information	98
In Memoriam: Ann Silver	89
Issue Information	89
Integrating respiration into sympathetic transduction to blood pressure	80
Issue Information	69
Can heat stress augment the cerebrovascular and neurotrophic benefits of exercise?	67
Corticothalamic modulation of somatosensory thalamic tactile processing	64
Maternal obesity alters myeloid immune function in the offspring	62
Decoding platelet loss in the hypoxic brain: What could go wrong?	61
Motor learning changes the axon initial segment of the spinal motoneuron	58
CrossTalk rebuttal	57
Pregnancy does not affect progression of mild experimental asthma in sheep	53
Theoretical analysis of power‐law stress relaxation and calcium‐dependent passive mechanics in cardiac muscle	49
Peripheral chemoreflex restrains skeletal muscle blood flow during exercise in participants with treated hypertension	48
CKAMP44 controls synaptic function and strength of relay neurons during early development of the dorsal lateral geniculate nucleus	47
Opening the door to physiological impacts underlying opioid‐induced respiratory depression and therapeutic strategies: focus on fentanyl	46
Magnesium sulphate reduces tertiary gliosis but does not improve EEG recovery or white or grey matter cell survival after asphyxia in preterm fetal sheep	46
Determinants and therapeutic potential of calcium handling abnormalities in atrial fibrillation: what can we learn from computer models?	45
Diarrhoeal pathogenesis in Salmonella infection may result from an imbalance in intestinal epithelial differentiation through reduced Notch signalling	45
Hypertension increases sympathetic neuron activity by enhancing intraganglionic cholinergic collateral connections	44
‘Evolutionary poker’: an agent‐based model of interactome emergence and epistasis tested against Lenski's long‐term E. coli experiments	43
Stroke severity shapes extracellular vesicle profiles and their impact on the cerebral endothelial cells	42
Ocular surface information seen from the somatosensory thalamus and cortex	42
Ventricular arrhythmogenic remodelling in diet‐induced metabolic syndrome driven by right‐to‐left regional differences in action potential duration and dominant frequency gradients	41

	41
Mitochondrial haplotype and sex modulate responses to endurance exercise training	40
Reply to ‘Reevaluating central versus peripheral contributions to maximal oxygen uptake: the role of muscle diffusive capacity’	38
Action potentials in postganglionic sympathetic nerves depend on NaV1.7	38
The endocrine kidney: tampering with oxygen sensors may change your character	37
Cerebral uptake of microvesicles occurs in normocapnic but not hypocapnic passive hyperthermia in young healthy male adults	37
The astrocytic Na+‐HCO3− cotransporter, NBCe1, is dispensable for respiratory chemosensitivity	37
Why you should pay more attention to your cells’ sex	37
The ups and downs of intermittent hypoxia as a therapy for ventilatory insufficiency	36
	36
Bayliss–Starling Prize Lecture: KATP channel pathophysiology – a whole‐body odyssey	36
The impact of androgens on cardiovascular control mechanisms in polycystic ovary syndrome: Recent advances and translational approaches	35
Changes in intra‐ and interlimb reflexes from forelimb cutaneous afferents after staggered thoracic lateral hemisections during locomotion in cats	35
Preferential lactate metabolism in the human brain during exogenous and endogenous hyperlactataemia	35
Uncertainty quantification via polynomial chaos expansion of myocardial fibre orientation and cardiac activation patterns	35
Breath taking fentanyl: how ether‐à‐go‐go potassium channels freeze your breath	35
Unveiling sex differences in skeletal muscle metabolism: the role of HIF1α in normoxia	35
Goal‐directed action preparation in humans entails a mixture of corticospinal neural computations	35
Augmenting workload drives T‐tubule assembly in developing cardiomyocytes	35
Heartbeat‐related activity in the anterior thalamus differs between phasic and tonic REM sleep	35
Semaglutide versus caloric restriction‐induced weight loss: insights into effects on skeletal muscle mass and function	35
Chronic intermittent hypoxia‐induced cardiovascular and renal dysfunction: from adaptation to maladaptation	34
Sensorimotor integration within the primary motor cortex by selective nerve fascicle stimulation	34
Lack of compensatory mitophagy in skeletal muscles during sepsis	34
Activation of the myosin motors in fast‐twitch muscle of the mouse is controlled by mechano‐sensing in the myosin filaments	34
Diversity of cells and signals in the cardiovascular system	33
Engineering the immune and fibrotic response in VML	32
Severe hypoxaemic hypercapnia compounds cerebral oxidative–nitrosative stress during extreme apnoea: Implications for cerebral bioenergetic function	32
Three‐dimensional printing of bioengineered scaffolds to support skeletal muscle regeneration	32
Angiotensin‐converting enzyme and exercise adaptations: Genetic variability, pharmacological modulation and future directions	32
High‐frequency electrical tuning and linear filter properties of Knollenorgan electroreceptors of mormyrid electric fish	32
Mitochondrial carbonic anhydrase VA and VB: properties and roles in health and disease	30
Issue Information	30
The 70‐year search for the voltage‐sensing mechanism of ion channels	30
Issue Information	30
An experiment of nature links muscle glycogen unavailability with very high fat oxidation rates despite low aerobic fitness	29
Response to ‘Comment on Wyrwoll et al., 2022: Long‐term exposure of mice to 890 ppm atmospheric CO2 alters growth trajectories and hyperactive behaviours in adults’ by Norman R. Saunders an	29
Issue Information	29
Want to hear ClC‐6 sing? Push your amp to eleven	29
Issue Information	29
Muscle déjà vu: are myonuclei the blueprint for muscle regrowth?	29
TMEM16A in gastrointestinal and vascular smooth muscle contractility	28
Multispectral brain connectivity during visual attention distinguishes controlled from uncontrolled hypertension	27
The non‐invasive assessment of muscle fibre size: has the future arrived?	27
Too hot to handle? Unveiling gut permeability during exertional heat stress	27
Muscle matters: exploring the contributions of ageing skeletal muscle to metabolic syndrome	27
Towards unravelling the exercise‐induced adaptations in circulating extracellular vesicles	27
Reply from D. R. Perkins and Mike Stembridge	27
Efficiency of cycling exercise: Understanding the physiology	26
Making ‘sense’ of what happens on the inside: il‘LUMEN'ating the effects of intestinal distention on calcium activity in enteric neurons	26

Loss of the alpha subunit distal furin cleavage site blunts ENaC activation following Na+ restriction	26
Release your inhibitions: The role of post‐inhibitory rebound and synaptic inhibition in the generation of expiratory activity	26
The fallacy of functional nomenclature in the kingdom of biological multifunctionality: physiological and evolutionary considerations on ion channels	25
Multi‐scale modelling of the effects of ageing, hypertension and exercise on the cerebral vasculature	25
Issue Information	25
Situating physiology within evolutionary theory	25
Speciation by physiological selection of environmentally acquired traits	25
Insulin potentiates the response to capsaicin in dorsal root ganglion neurons in vitro and muscle afferents ex vivo in normal healthy rodents	25
Corrigendum	25
	25
Hypoxic sensitivity and burden predict propensity for respiratory plasticity in humans	25
Cathodal bilateral transcranial direct‐current stimulation regulates selenium to confer neuroprotection after rat cerebral ischaemia–reperfusion injury	25
Macrophage microvesicle‐derived circ_YTHDF2 in methamphetamine‐induced chronic lung injury	25
Microglial phagocytosis in epilepsy: Mechanisms and impact	24
Muscle memory theory: Implications for health, athletic performance and sports integrity	24
The diverse functions of the DEG/ENaC family: linking genetic and physiological insights	24
From signals to systems: Mapping the complex physiology of cardiorespiratory dynamics with information theory	24
Advances in cardiac devices and bioelectronics augmented with artificial intelligence	24
Presynaptic H 3 receptor: A modulator for CeL excitatory‐inhibitory homeostasis	24
Synaptic loss in motor neurons precipitates age‐related dysphagia: Middle agers gotta keep in touch!	24
Sexual dimorphism: increased sterol excretion leads to hypocholesterolaemia in female hyperbilirubinaemic Gunn rats	24
Clenbuterol induces lean mass and muscle protein accretion, but attenuates cardiorespiratory fitness and desensitizes muscle β2‐adrenergic signalling	23
Hyperglycaemia, pregnancy outcomes and maternal metabolic disease risk during pregnancy and lactation in a lean gestational diabetes mouse model	23
Dietary nitrate supplementation improves age‐associated neuromuscular outcomes: A step towards healthy ageing	23
The potential therapeutic benefits of low frequency haemodynamic oscillations	23
Neural Modulations during the Stretch–Shortening Cycle: The Importance of Movement Velocity and Task Specificity	23
A cross‐species validation of single‐beat metrics of cardiac contractility	23
Inhibitory circuit motifs of cortical somatosensory layer 5 SST interneurons are uniform within layers but specific across layers	23
The neural control of movement: a century of in vivo motor unit recordings is the legacy of Adrian and Bronk	23
Inflammatory gene expression during acute high‐altitude exposure	23
Bioavailable testosterone and androgen receptor activation, but not total testosterone, are associated with muscle mass and strength in females	23
Optical mapping of contracting hearts	23
Properties and modulation of excitatory inputs to the locus coeruleus	23
Action potential amplitude and baroreflex resetting of action potential clusters mediate hypoxia‐induced sympathetic long‐term facilitation	23
Volitional exercise elicits physiological and molecular improvements in the severe D2.mdx mouse model of Duchenne muscular dystrophy	23
Thermodynamic limitations on brain oxygen metabolism: physiological implications*	22
The pathological blood flow steal phenomenon limits exercise tolerance in pulmonary hypertensive rats	22
Ageing reduces persistent inward current contribution to motor neurone firing: Potential mechanisms and the role of exercise	22
Extracellular vesicles and their non‐coding RNA cargos: Emerging players in cardiovascular disease	22
	22
Fast and sensitive GCaMP calcium indicators for neuronal imaging	22
Flex and flow: are we receptive to all females in muscle physiology research?	22
Issue Information	21
Reorganization of mitochondria–organelle interactions during postnatal development in skeletal muscle	21
Use it or lose it: protecting ageing muscles with lifelong recreational exercise	21
Beat‐to‐beat QT interval variability as a tool to detect the underlying cellular mechanisms of arrhythmias	21
The key to our hearts: Unlocking fundamental sex differences in mouse cardiomyocyte calcium‐cycling	21
Beeting atrophy: dietary nitrate to protect the powerhouse of the cell?	21
An automated respiratory data pipeline for waveform characteristic analysis	21
Ketogenic diet and ketone salts differentially improve cardiometabolic complications in an HFpEF rat model	21
Central α2‐adrenergic mechanisms regulate human sympathetic neuronal discharge strategies	20
Respiratory control at high altitude: The chemoreceptor as a paragon of plasticity	20
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Adenine nucleotide translocator and ATP synthase cooperate in mediating the mitochondrial permeability transition	20
Critical molecular outcomes of time‐restricted feeding during ageing: a look beyond body composition	20
Who's on first … Na+, HCO3− or CO32−?	20
Something's fishy: cardiovascular ATP‐sensitive K+ channels in zebrafish	20
TET2 confers a mechanistic link of microRNA‐210 and mtROS in hypoxia‐suppressed spontaneous transient outward currents in uterine arteries of pregnant sheep	20
CPT1C is required for synaptic plasticity and oscillatory activity that supports motor, associative and non‐associative learning	20
Maternal sleep behaviours preceding fetal heart rate events on cardiotocography	20
Whole‐body metabolic rate is influenced by muscle fibre typology	20
Adrenergic restraint of blood flow and high‐altitude acclimatization	20
Exercise intolerance in pulmonary hypertension: robbing Peter to pay Paul	20
Issue Information	20
A game of chest: Where does blood volume shift?	20
The time is now: regular exercise maintains vascular health in ageing women	20
The effects of local vibration inducing a tonic vibration reflex or movement illusion on acute modulations of corticospinal excitability	20
The complexity of Nrf2 in experimental autoimmune myositis‐induced mice	20
Characterizing the effects of type I collagen alterations on respiratory function in mouse models with varying severity of osteogenesis imperfecta	20
Past questions, present results, future perspectives: Interacting chemosensitive areas and the hypercapnic ventilatory response	20
Novel regenerative drug, SPG302 promotes functional recovery of diaphragm muscle activity after cervical spinal cord injury	19
Nav1.2 and BK channel interaction shapes the action potential in the axon initial segment	19
Towards spatially selective efferent neuromodulation: anatomical and functional organization of cardiac fibres in the porcine cervical vagus nerve	19
Pump up the volume: breathing facilitates cardiac output during exercise by mechanical action	19
Glyoxalase 1 overexpression improves neurovascular coupling and limits development of mild cognitive impairment in a mouse model of type 1 diabetes	19
Intrinsic motoneuron properties in typical human development	19
A systematic review of computational models for the design of spinal cord stimulation therapies: from neural circuits to patient‐specific simulations	19
Reduced plakoglobin increases the risk of sodium current defects and atrial conduction abnormalities in response to androgenic anabolic steroid abuse	19
Circadian patterns of heart rate variability in fetal sheep after hypoxia‐ischaemia: A biomarker of evolving brain injury	19
The cardiac sodium channel from function to dysfunction	19

Muscular strength, endothelial function and cognitive disorders: state of the art	19
Oncomodulin regulates spontaneous calcium signalling and maturation of afferent innervation in cochlear outer hair cells	19
Crosstalk between biochemical signalling network architecture and trafficking governs AMPAR dynamics in synaptic plasticity	19
Metabolite‐sensitive cross‐bridge models of human atria reveal the impact of diabetes on muscle mechanoenergetics	19
Particle‐swarm based modelling reveals two distinct classes of CRH PVN neurons	19
Astrocytes: Orchestrators of brain gas exchange and oxygen homeostasis	19
Mechano‐electrical interactions and heterogeneities in wild‐type and drug‐induced long QT syndrome rabbits	19
Pathogenic TNNT1 variants are associated with aberrant thin filament compliance and myofibre hyper‐contractility	19
Issue Information	18
Age‐related diaphragm dysfunction: could diaphragm arteriole dysfunction be to blame?	18
Exercise affects fatty acid oxidation and lipid droplets in patients with type 2 diabetes	18
Issue Information	18
Expiratory flow limitation during exercise: why does it ‘suck’ so much?	18
Issue Information	18
CCK‐elicited pancreatic Ca 2+ signal generation is probably not initiated by IP 3 formation	18
Ageing impairs endothelium‐dependent vasodilatation and alters redox signalling in diaphragm arterioles from male and female Fischer‐344 rats	18
A detailed mathematical model of the human atrial cardiomyocyte: integration of electrophysiology and cardiomechanics	18
Untangling age and menopause: vascular mechanisms for cardiovascular disease risk in females	18
Insulin, Nobel laureates and The Journal of Physiology	18
Fasting and the short‐term consumption of a ketogenic diet are sufficient interventions to protect against OLZ‐induced hyperglycaemia in mice	18
Exosomes and the cardiovascular system: role in cardiovascular health and disease	18
Neurobiology of mitochondrial dynamics in sleep	18
Issue Information	18
Comparison of excitation–contraction coupling between Drosophila and vertebrate muscle	18
Symptom‐modifying strategy to treat upper respiratory tract infections: a clinical and mechanistic evidence of ColdZyme	18
Becoming mindful of mindfulness: a promising approach to reducing sympathetic nervous system overactivity in chronic kidney disease	18
Translating physiology of the arterial chemoreflex into novel therapeutic interventions targeting carotid bodies in cardiometabolic disorders	18
Neuroinflammation and the immune system in hypoxic ischaemic brain injury pathophysiology after cardiac arrest	18
The post‐arteriole transitional zone: a specialized capillary region that regulates blood flow within the CNS microvasculature	18
Vaping for two: unravelling the mysteries of E‐cigarettes and fetal vascular health	17
Rebuttal from Amy Richardson and Gareth Morris	17
Muscle–fat crosstalk: effects of exercise on brown adipose tissue; what do we know?	17
Beyond the madness: a balanced approach to standardization, practicality and innovation in exercise physiology threshold assessment	17
Cross Talk proposal: Human‐derived brain tissue is a better epilepsy model than animal‐based approaches	17
Channelling protons out of the heart	17
Scale‐invariant changes in corticospinal excitability reflect multiplexed oscillations in the motor output	17
Endurance training increases a ubiquitylated form of histone H3 in the skeletal muscle, supporting Notch1 upregulation in an MDM2‐dependent manner	17
Now and then: Development of spinal Shox2 neurons	17
State‐dependent neural representations of muscle synergies in the spinal cord revealed by optogenetic stimulation	17
Mitochondrial function in brain and muscle metabolism: the crucial role during early sensorimotor development	17
Chemoreflex function in pulmonary diseases – A review	17
Oxytocin and corticotropin‐releasing hormone exaggerate nucleus tractus solitarii neuronal and synaptic activity following chronic intermittent hypoxia	17
When right ventricular pressure meets volume: The impact of arrival time of reflected waves on right ventricle load in pulmonary arterial hypertension	17
What is fetal growth restriction and how might we know?	17
Atypical delayed paired‐pulse depression at an identified synapse	17
Correction to ‘A single bout of prior resistance exercise attenuates muscle atrophy and declines in myofibrillar protein synthesis during bed‐rest in older men’	17
Blebbistatin reduces calcium buffering in cardiomyocytes: Consequences for cellular electrophysiology	17
Evolution of rod bipolar cells and rod vision	16
Loss of anoctamin 1 reveals a subtle role for BK channels in lymphatic muscle action potentials	16
High altitude differentially modulates potassium channel‐evoked vasodilatation in pregnant human myometrial arteries	16
Extracellular vesicles and their microRNA cargo in ischaemic stroke	16
Time course and fibre type‐dependent nature of calcium‐handling protein responses to sprint interval exercise in human skeletal muscle	16
A narrative review of periodic breathing during sleep at high altitude: From acclimatizing lowlanders to adapted highlanders	16
Neural coordination of bilateral hand movements: evidence for an involvement of brainstem motor centres	16
Myosin motor dynamics and cardiac function: Insights from in vivo small‐angle X‐ray scattering and pressure–volume analysis	16
Deficiency of PKA‐mediated SNAP‐25b phosphorylation destabilizes exocytotic fusion pores and reduces the interactions of t‐SNAREs	16
Stepping up to inspire in muscular dystrophy	16
Ubiquitin ligase signalling networks shape presynaptic development, function and disease	16
The cardiac pacemakers: A paradigm of robustness in evolutionary biology	16
Transient capacitance changes recorded from vestibular type I hair cells are produced by GK,L gating and do not involve neurotransmitter exocytosis	16
Enter Sandman: An eye opening opinion of cardiovascular disease prevention in cervical spinal cord injury	16
Directional sensitivity of C‐low‐threshold mechanoreceptors: insights from in vivo calcium imaging	16
Presynaptic quantal size enhancement counteracts post‐tetanic release depression	16
Activation of TRPA1 and TRPM3 triggers Ca 2+ waves in central terminals of sensory neurons and facilitates synaptic activity in the spinal dorsal hor	16
Notch1 promotes ordered revascularization through Semaphorin 3g modulation of downstream vascular patterning signalling factors	16
Ca2+ signalling in interstitial cells of Cajal contributes to generation and maintenance of tone in mouse and monkey lower oesophageal sphincters	15
Persistent hypoxia after birth limits cerebrovascular myogenic and autoregulatory capacity when oxygenation is restored	15
Muscle‐derived IL‐1β regulates EcSOD expression via the NBR1‐p62‐Nrf2 pathway in muscle during cancer cachexia	15
Can muscle typology explain the inter‐individual variability in resistance training adaptations?	15
Plasma measurements of the dual sugar test reveal carbohydrate immediately alleviates intestinal permeability caused by exertional heat stress	15
Pancreatic acinar cell signalling and function exhibit an absolute requirement for activation of Gαq	15
Exercise‐induced arterial hypoxaemia in patients with heart failure with preserved ejection fraction	15
Ageing‐induced weakness of mouse NMJs is associated with reduced active zone density, synaptic event kinetics and presynaptic calcium entry	15
Paraventricular nucleus projections to the nucleus tractus solitarii are essential for full expression of hypoxia‐induced peripheral chemoreflex responses	15
Annual Prize Lecture 2024: Endogenous physiological mechanisms as basis for the treatment of obesity and type 2 diabetes	15
Interstitial cells of Cajal – pacemakers of the gastrointestinal tract	15
Enhancing stroke risk stratification in atrial fibrillation through non‐Newtonian blood modelling and Gaussian process emulation	15
The complex function of macrophages and their subpopulations in metabolic injury associated fatty liver disease	15
Adeno‐associated virus‐based rescue of Myo7a expression restores hair‐cell function and improves hearing thresholds in a USH1B	15
Autonomic modulation with mindfulness‐based stress reduction in chronic kidney disease: a randomized controlled trial	15
Exercise, healthy ageing, and the potential role of small extracellular vesicles	15
Endurance exercise training changes the limitation on muscle V̇O2max${\dot{V}}_{{{\mathrm{O}}}_{\mathrm{2}}{\mathrm{max}}}$ in normoxia from the capacity to utilize O2 to the capacity to tr	15
Fluorescent biosensor imaging meets deterministic mathematical modelling: quantitative investigation of signalling compartmentalization	15
Phase‐dependent local brain states determine the impact of image‐guided transcranial magnetic stimulation on motor network electroencephalographic synchronization	15
Homeostasis and evolution in relation to regeneration and repair	15
‘Mini analysis’ misrepresents changes in synaptic properties due to incomplete event detection	15
Cardiac programming in the placentally restricted sheep fetus in early gestation	15
The legacy of A. V. Hill's Nobel Prize winning work on muscle energetics	15
How neural networks walk and chew gum	14
The link between sarcopenic obesity and Alzheimer's disease: a brain‐derived neurotrophic factor point of view	14
Divergent splanchnic sympathetic efferent nerve pathways regulate interleukin‐10 and tumour necrosis factor‐α responses to endotoxaemia	14
High‐definition transcranial direct‐current stimulation of left primary motor cortices modulates beta and gamma oscillations serving motor control	14
Slowly‐adapting type II afferents contribute to conscious touch sensation in humans: Evidence from single unit intraneural microstimulation	14
Pedalling toward a deeper understanding of exercise effects on immune function	14
C‐tactile afferents: The mystery of human emotional touch has been hidden hair‐deep	14