Journal of Physiology-London

Article	Citations
Regulation of glycolysis by the hypoxia‐inducible factor (HIF): implications for cellular physiology	419
Revisiting the Warburg effect: historical dogma versus current understanding	403
The ARRIVE guidelines 2.0: updated guidelines for reporting animal research	184
The anaerobic threshold: 50+ years of controversy	161
Lactate in contemporary biology: a phoenix risen	94
Hepatic stellate cells in physiology and pathology	79
Effects of e‐cigarettes and vaping devices on cardiac and pulmonary physiology	76
Intra‐gastrointestinal amyloid‐β1–42 oligomers perturb enteric function and induce Alzheimer's disease pathology	73
Drp1 knockdown induces severe muscle atrophy and remodelling, mitochondrial dysfunction, autophagy impairment and denervation	66
COVID‐19 is getting on our nerves: sympathetic neural activity and haemodynamics in young adults recovering from SARS‐CoV‐2	62
Silent hypoxaemia in COVID‐19 patients	61
Neuromuscular junction instability and altered intracellular calcium handling as early determinants of force loss during unloading in humans	61
Adaptation to a low carbohydrate high fat diet is rapid but impairs endurance exercise metabolism and performance despite enhanced glycogen availability	58
Inter‐hemispheric inhibition sculpts the output of neural circuits by co‐opting the two cerebral hemispheres	58
In vivo recordings from the human vagus nerve using ultrasound‐guided microneurography	57
Nitric oxide is fundamental to neurovascular coupling in humans	53
Low‐volume high‐intensity interval training for cardiometabolic health	53
Functional architecture of the motor homunculus detected by electrostimulation	52
The envelope protein of SARS‐CoV‐2 increases intra‐Golgi pH and forms a cation channel that is regulated by pH	52
Sex differences in fatigability following exercise normalised to the power–duration relationship	50
The noradrenergic agent reboxetine plus the antimuscarinic hyoscine butylbromide reduces sleep apnoea severity: a double‐blind, placebo‐controlled, randomised crossover trial	46
Lifelong voluntary aerobic exercise prevents age‐ and Western diet‐ induced vascular dysfunction, mitochondrial oxidative stress and inflammation in mice	46
Time‐of‐day dependent effects of contractile activity on the phase of the skeletal muscle clock	46
TRPV1 expressed throughout the arterial circulation regulates vasoconstriction and blood pressure	45
Architecture and function of NMDA receptors: an evolutionary perspective	44

Synergic control of a single muscle: The example of flexor digitorum superficialis	44
Zolpidem increases sleep efficiency and the respiratory arousal threshold without changing sleep apnoea severity and pharyngeal muscle activity	43
Estimates of persistent inward currents are reduced in upper limb motor units of older adults	43
Piezo1 channels mediate trabecular meshwork mechanotransduction and promote aqueous fluid outflow	43
Genetic and epigenetic regulation of skeletal muscle ribosome biogenesis with exercise	42
Passive stiffness of fibrotic skeletal muscle in mdx mice relates to collagen architecture	42
Ca2+‐permeable AMPA receptors and their auxiliary subunits in synaptic plasticity and disease	42
Physiological and molecular sex differences in human skeletal muscle in response to exercise training	41
Fitness and strength responses to distinct exercise modes in twins: Studies of Twin Responses to Understand Exercise as a THerapy (STRUETH) study	41
Functional, proteomic and bioinformatic analyses of Nrf2‐ and Keap1‐ null skeletal muscle	38
Internal carotid and brachial artery shear‐dependent vasodilator function in young healthy humans	38
Deficit in knee extension strength following anterior cruciate ligament reconstruction is explained by a reduced neural drive to the vasti muscles	38
Pregnancy‐induced changes in β‐cell function: what are the key players?	37
The mechanisms of skeletal muscle atrophy in response to transient knockdown of the vitamin D receptor in vivo	37
Distinct features of calcium handling and β‐adrenergic sensitivity in heart failure with preserved versus reduced ejection fraction	37
Positive allosteric modulation of NMDA receptors: mechanisms, physiological impact and therapeutic potential	36
In vitro ketone‐supported mitochondrial respiration is minimal when other substrates are readily available in cardiac and skeletal muscle	36
Influence of sex on the age‐related adaptations of neuromuscular function and motor unit properties in elite masters athletes	36
Autonomic control of cerebral blood flow: fundamental comparisons between peripheral and cerebrovascular circulations in humans	34
Common synaptic input, synergies and size principle: Control of spinal motor neurons for movement generation	34
Nicotinamide riboside supplementation does not alter whole‐body or skeletal muscle metabolic responses to a single bout of endurance exercise	34
Divergence of neuroimmune circuits activated by afferent and efferent vagal nerve stimulation in the regulation of inflammation	34
August Krogh's theory of muscle microvascular control and oxygen delivery: a paradigm shift based on new data	34
Respiratory cerebrospinal fluid flow is driven by the thoracic and lumbar spinal pressures	33
1,25(OH)2 vitamin D3 stimulates active phosphate transport but not paracellular phosphate absorption in mouse intestine	32
Current research: effect of time restricted eating on weight and cardiometabolic health	32
The influence of aerobic exercise on mitochondrial quality control in skeletal muscle	32
Age‐related changes in the biophysical and morphological characteristics of mouse cochlear outer hair cells	32
Time restricted eating for the prevention of type 2 diabetes	32
Encoding sound in the cochlea: from receptor potential to afferent discharge	31
Transcriptomic, proteomic and phosphoproteomic underpinnings of daily exercise performance and zeitgeber activity of training in mouse muscle	31
Mitochondrial dysfunction in placental trophoblast cells experiencing gestational diabetes mellitus	31
Modulation of Kv3.1/Kv3.2 promotes gamma oscillations by rescuing Aβ‐induced desynchronization of fast‐spiking interneuron firing in an AD mouse model in vitro	31
The need for specificity in quantifying neurocirculatory vs. respiratory effects of eucapnic hypoxia and transient hyperoxia	30
Chronic cold exposure induces mitochondrial plasticity in deer mice native to high altitudes	30
Extracellular miRNAs as mediators of obesity‐associated disease	30
E‐cigarettes, nicotine, the lung and the brain: multi‐level cascading pathophysiology	30
Step time asymmetry but not step length asymmetry is adapted to optimize energy cost of split‐belt treadmill walking	30
Spinal motoneurones are intrinsically more responsive in the adult G93A SOD1 mouse model of amyotrophic lateral sclerosis	30
Peripheral chemoreflex contribution to ventilatory long‐term facilitation induced by acute intermittent hypercapnic hypoxia in males and females	29
Loss of Baiap2l2 destabilizes the transducing stereocilia of cochlear hair cells and leads to deafness	29
Single muscle fibre contractile function with ageing	28
On the role of skeletal muscle acidosis and inorganic phosphates as determinants of central and peripheral fatigue: A 31P‐MRS study	28
Localization of Na+ channel clusters in narrowed perinexi of gap junctions enhances cardiac impulse transmission via ephaptic coupling: a model study	28
Photoreceptor physiology and evolution: cellular and molecular basis of rod and cone phototransduction	28
Orexin neurons and inhibitory Agrp→orexin circuits guide spatial exploration in mice	27
Contraction influences Per2 gene expression in skeletal muscle through a calcium‐dependent pathway	27
Effects of reciprocal inhibition and whole‐body relaxation on persistent inward currents estimated by two different methods	27
Heterogeneity in subcellular muscle glycogen utilisation during exercise impacts endurance capacity in men	27
Biochemical and structural basis of the passive mechanical properties of whole skeletal muscle	27

Analysis of extracellular spike waveforms and associated receptive fields of neurons in cat primary visual cortex	27
The correspondence between EMG and EEG measures of changes in cortical excitability following transcranial magnetic stimulation	27
Peripheral chemoreflex control of fetal heart rate decelerations overwhelms the baroreflex during brief umbilical cord occlusions in fetal sheep	27
Direct evidence for decreased presynaptic inhibition evoked by PBSt group I muscle afferents after chronic SCI and recovery with step‐training in rats	26
The beta2‐adrenergic receptor – a re‐emerging target to combat obesity and induce leanness?	26
Time‐dependent changes in autophagy, mitophagy and lysosomes in skeletal muscle during denervation‐induced disuse	26
Myosin dynamics during relaxation in mouse soleus muscle and modulation by 2′‐deoxy‐ATP	26
Regulation of plasma volume in male lowlanders during 4 days of exposure to hypobaric hypoxia equivalent to 3500 m altitude	26
Inhibitory interneurons regulate phasic activity of noradrenergic neurons in the mouse locus coeruleus and functional implications	26
Near‐infrared spectroscopy estimation of combined skeletal muscle oxidative capacity and O2 diffusion capacity in humans	26
Abnormal placental CD8+ T‐cell infiltration is a feature of fetal growth restriction and pre‐eclampsia	25
Biophysical and morphological changes in inner hair cells and their efferent innervation in the ageing mouse cochlea	25
Evidence for improved systemic and local vascular function after long‐term passive static stretching training of the musculoskeletal system	25
Hypertrophied human adipocyte spheroids as in vitro model of weight gain and adipose tissue dysfunction	25
Exertional heat stroke leads to concurrent long‐term epigenetic memory, immunosuppression and altered heat shock response in female mice	25
Vitamin D is an endogenous partial agonist of the transient receptor potential vanilloid 1 channel	25
Modulation of information processing by AMPA receptor auxiliary subunits	25
Physiology of physical inactivity, sedentary behaviours and non‐exercise activity: insights from the space bedrest model	24
Biased auditory nerve central synaptopathy is associated with age‐related hearing loss	24
Acute activation of bronchopulmonary vagal nociceptors by type I interferons	24
Towards a mechanistic approach for the development of non‐invasive brain‐computer interfaces for motor rehabilitation	24
Regulation of muscle and mitochondrial health by the mitochondrial fission protein Drp1 in aged mice	24
Zona incerta neurons projecting to the ventral tegmental area promote action initiation towards feeding	24
Optical measurement of physiological sodium currents in the axon initial segment	24
Inhibitory control of active expiration by the Bötzinger complex in rats	24
Locomotor muscle group III/IV afferents constrain stroke volume and contribute to exercise intolerance in human heart failure	24
Physiological aspects of cardiopulmonary dysanapsis on exercise in adults born preterm	24
Advancing respiratory–cardiovascular physiology with the working heart–brainstem preparation over 25 years	24
Vascular calcium signalling and ageing	23
Dysbiosis of the gut microbiome impairs mouse skeletal muscle adaptation to exercise	23
Ageing and exercise‐induced motor unit remodelling	23
Peripheral impairments of oxidative metabolism after a 10‐day bed rest are upstream of mitochondrial respiration	23
Abnormal skeletal muscle blood flow, contractile mechanics and fibre morphology in a rat model of obese‐HFpEF	23
Nutrient timing and metabolic regulation	23
Acid–base balance and cerebrovascular regulation	23
Exosome engineering for efficient and targeted drug delivery: Current status and future perspective	23
Long‐duration spaceflight alters estimated intracranial pressure and cerebral blood velocity	22
NMDA receptors in axons: there's no coincidence	22
Pathophysiological changes in inner hair cell ribbon synapses in the ageing mammalian cochlea	22
Vesicle‐released glutamate is necessary to maintain muscle spindle afferent excitability but not dynamic sensitivity in adult mice	22
The suitability of high throughput automated patch clamp for physiological applications	22
Nitric oxide contributes to cerebrovascular shear‐mediated dilatation but not steady‐state cerebrovascular reactivity to carbon dioxide	22
Effects of short‐term unloading and active recovery on human motor unit properties, neuromuscular junction transmission and transcriptomic profile	22
Skeletal muscle AMPK is not activated during 2 h of moderate intensity exercise at ∼65% in endurance trained men	22
Differential effects of motor skill acquisition on the primary motor and sensory cortices in healthy humans	22
Glial amplification of synaptic signals	22
Facilitation–inhibition control of motor neuronal persistent inward currents in young and older adults	22
Inhaled nitric oxide improves ventilatory efficiency and exercise capacity in patients with mild COPD: A randomized‐control cross‐over trial	22
Time‐restricted feeding combined with aerobic exercise training can prevent weight gain and improve metabolic disorders in mice fed a high‐fat diet	22
Arterial carbon dioxide and bicarbonate rather than pH regulate cerebral blood flow in the setting of acute experimental metabolic alkalosis	22
The effects of maternal position, in late gestation pregnancy, on placental blood flow and oxygenation: an MRI study	21
Fetal growth, birth size and energetic cost of gestation in southern right whales	21
Interpreting ‘anti‐inflammatory’ cytokine responses to exercise: focus on interleukin‐10	21
How does oxygen diffuse from capillaries to tissue mitochondria? Barriers and pathways	21
Spinal motoneuron firing properties mature from rostral to caudal during postnatal development of the mouse	21
NAD+ and NAFLD – caution, causality and careful optimism	21
Intermuscular coherence analysis in older adults reveals that gait‐related arm swing drives lower limb muscles via subcortical and cortical pathways	21
GluN3A NMDA receptor subunits: more enigmatic than ever?	20
Exposure to high fructose corn syrup during adolescence in the mouse alters hepatic metabolism and the microbiome in a sex‐specific manner	20
Hypothalamic–vagal oxytocinergic neurocircuitry modulates gastric emptying and motility following stress	20
Peroxisomal proliferator‐activated receptor α‐b deficiency induces the reprogramming of nutrient metabolism in zebrafish	20
Correlation networks of spinal motor neurons that innervate lower limb muscles during a multi‐joint isometric task	20
The role of mitochondria in metabolic disease: a special emphasis on heart dysfunction	20
Location, location, location: the organization and roles of potassium channels in mammalian motoneurons	20
PKCε stimulation of TRPV1 orchestrates carotid body responses to asthmakines	20
Blockade of 5‐HT2 receptors suppresses motor unit firing and estimates of persistent inward currents during voluntary muscle contraction in humans	19
Modelling unitary fields and the single‐neuron contribution to local field potentials in the hippocampus	19
Role of pattern recognition receptors and the microbiota in neurological disorders	19
Intrinsic and synaptic mechanisms controlling the expiratory activity of excitatory lateral parafacial neurones of rats	19
CrossTalk opposing view: NKCC1 in the luminal membrane of choroid plexus is outwardly directed under basal conditions and contributes directly to cerebrospinal fluid secretion	19
Influence of blood flow occlusion on muscular recruitment and fatigue during maximal‐effort small muscle‐mass exercise	19
Divergent immunometabolic changes in adipose tissue and skeletal muscle with ageing in healthy humans	19
Maternal exercise attenuates the lower skeletal muscle glucose uptake and insulin secretion caused by paternal obesity in female adult rat offspring	19
Evidence for multiple bulbar and higher brain circuits processing sensory inputs from the respiratory system in humans	19
Biological sex, not reproductive cycle, influences peripheral blood immune cell prevalence in mice	19
Maternal obesity causes fetal cardiac hypertrophy and alters adult offspring myocardial metabolism in mice	18
The capillary fascicle in skeletal muscle: Structural and functional physiology of RBC distribution in capillary networks	18
An MRI approach to assess placental function in healthy humans and sheep	18
What gets on the nerves of cardiac patients? Pathophysiological changes in cardiac innervation	18
Functional development and regeneration of hair cells in the zebrafish lateral line	18

Junctophilin‐4 facilitates inflammatory signalling at plasma membrane‐endoplasmic reticulum junctions in sensory neurons	18
Quantification of cardiac and respiratory modulation of axonal activity in the human vagus nerve	18
Connexin 46 and connexin 50 gap junction channel properties are shaped by structural and dynamic features of their N‐terminal domains	18
Sex differences in the sympathetic neurocirculatory responses to chemoreflex activation	18
Publications, replication and statistics in physiology plus two neglected curves	18
Gut peptide regulation of food intake – evidence for the modulation of hedonic feeding	18
Vagus nerve stimulation activates nucleus of solitary tract neurons via supramedullary pathways	18
Rapid volume pulsation of the extracellular space coincides with epileptiform activity in mice and depends on the NBCe1 transporter	18
Adipocyte function and the development of cardiometabolic disease	18
Endocytic adaptation to functional demand by the kidney proximal tubule	18
Optogenetic approaches to therapy for inherited retinal degenerations	18
Inflammatory gene expression during acute high‐altitude exposure	17
Influence of iron manipulation on hypoxic pulmonary vasoconstriction and pulmonary reactivity during ascent and acclimatization to 5050 m	17
The 70‐year search for the voltage‐sensing mechanism of ion channels	17
The ketogenic diet prevents steatosis and insulin resistance by reducing lipogenesis, diacylglycerol accumulation and protein kinase C activity in male rat liver	17
Desmin prevents muscle wasting, exaggerated weakness and fragility, and fatigue in dystrophic mdx mouse	17
Phenotyping heart failure using model‐based analysis and physiology‐informed machine learning	17
Abnormal cerebellar function and tremor in a mouse model for non‐manifesting partially penetrant dystonia type 6	17
Bugs, breathing and blood pressure: microbiota–gut–brain axis signalling in cardiorespiratory control in health and disease	17
Glucocorticoids regulate mitochondrial fatty acid oxidation in fetal cardiomyocytes	17
Na+ is shifted from the extracellular to the intracellular compartment and is not inactivated by glycosaminoglycans during high salt conditions in rats	17
Circadian actions of orexins on the retinorecipient lateral geniculate complex in rat	17
Oxygenation pattern and compensatory responses to hypoxia and hypercapnia following bilateral carotid body resection in humans	17
Increasing SERCA function promotes initiation of calcium sparks and breakup of calcium waves	17
Influence of the mode of heating on cerebral blood flow, non‐invasive intracranial pressure and thermal tolerance in humans	17
Oxidant‐resistant LRRC8A/C anion channels support superoxide production by NADPH oxidase 1	17
Resilience of neural networks for locomotion	17
S100β‐mediated astroglial control of firing and input processing in layer 5 pyramidal neurons of the mouse visual cortex	17
Mitochondrial carbonic anhydrase VA and VB: properties and roles in health and disease	17
Motor unit dysregulation following 15 days of unilateral lower limb immobilisation	17
Remote ischaemic preconditioning – translating cardiovascular benefits to humans	17
Motor potentials evoked by transcranial magnetic stimulation: interpreting a simple measure of a complex system	17
Selective activation of BK channels in small‐headed dendritic spines suppresses excitatory postsynaptic potentials	16
Obesity and gestational diabetes independently and collectively induce specific effects on placental structure, inflammation and endocrine function in a cohort of South African women	16
Structural basis for positive allosteric modulation of AMPA and kainate receptors	16
Rapamycin and mTORC2 inhibition synergistically reduce contraction‐stimulated muscle protein synthesis	16
AMP‐activated protein kinase activation in skeletal muscle modulates exercise‐induced uncoupled protein 1 expression in brown adipocyte in mouse model	16
Physical activity and advanced cancer: evidence of exercise‐sensitive genes regulating prostate cancer cell proliferation and apoptosis	16
Cortical layer 6 control of sensory responses in higher‐order thalamus	16
Maternal but not fetoplacental health can be improved by metformin in a murine diet‐induced model of maternal obesity and glucose intolerance	16
Breathing in Duchenne muscular dystrophy: translation to therapy	16
‘Resistance is futile?’ – paradoxical inhibitory effects of KATP channel closure in glucagon‐secreting α‐cells	16
Disproportionate loss of excitatory inputs to smaller phrenic motor neurons following cervical spinal hemisection	16
Sexually dimorphic response of colorectal motility to noxious stimuli in the colorectum in rats	16
Naked mole‐rat brain mitochondria tolerate in vitro ischaemia	16
Mechanisms of Hebbian‐like plasticity in the ventral premotor – primary motor network	16
Late gestation fetal hyperglucagonaemia impairs placental function and results in diminished fetal protein accretion and decreased fetal growth	16
Exon 2‐mediated deletion of Trem2 does not worsen metabolic function in diet‐induced obese mice	16
The molecular mechanism of CFTR‐ and secretin‐dependent renal bicarbonate excretion	16
Preserved skeletal muscle oxidative capacity in older adults despite decreased cardiorespiratory fitness with ageing	16
Short‐term ketone monoester supplementation improves cerebral blood flow and cognition in obesity: A randomized cross‐over trial	16
Preserved stem cell content and innervation profile of elderly human skeletal muscle with lifelong recreational exercise	16
Emerging roles of the TRPV4 channel in bladder physiology and dysfunction	16
Regulation of cardiovascular health and disease by visceral adipose tissue‐derived metabolic hormones	16
Physiological roles of heteromerization: focus on the two‐pore domain potassium channels	16
Exercise training remodels subcutaneous adipose tissue in adults with obesity even without weight loss	16
Angiogenic potential is reduced in skeletal muscle of aged women	15
Low energy availability reduces myofibrillar and sarcoplasmic muscle protein synthesis in trained females	15
Divergent splanchnic sympathetic efferent nerve pathways regulate interleukin‐10 and tumour necrosis factor‐α responses to endotoxaemia	15
Acute reductions in haematocrit increase flow‐mediated dilatation independent of resting nitric oxide bioavailability in humans	15
Tetraspanin‐7 regulation of L‐type voltage‐dependent calcium channels controls pancreatic β‐cell insulin secretion	15
A sodium background conductance controls the spiking pattern of mouse adrenal chromaffin cells in situ	15
The LRRC family of BK channel regulatory subunits: potential roles in health and disease	15
Critical considerations of the contribution of the corticomotoneuronal pathway to central fatigue	15
Rhythmic neuronal activities of the rat nucleus of the solitary tract are impaired by high‐fat diet – implications for daily control of satiety	15
Leptin mediates the regulation of muscle mass and strength by adipose tissue	15
Neurovascular and cortical responses to hyperoxia: enhanced cognition and electroencephalographic activity despite reduced perfusion	15
Carbohydrate improves exercise capacity but does not affect subcellular lipid droplet morphology, AMPK and p53 signalling in human skeletal muscle	15
Excessive endoplasmic reticulum stress drives aberrant mouse trophoblast differentiation and placental development leading to pregnancy loss	15
Sex differences in diaphragmatic fatigue: Effects of hypoxia during inspiratory loading	15
A molecular signature defining exercise adaptation with ageing and in vivo partial reprogramming in skeletal muscle	15
Fast and sensitive GCaMP calcium indicators for neuronal imaging	15
The current chemical biology tool box for studying ion channels	15
Nitric oxide synthase inhibition in healthy adults reduces regional and total cerebral macrovascular blood flow and microvascular perfusion	14
Temporal control of muscle synergies is linked with alpha‐band neural drive	14
β‐Catenin is required for optimal exercise‐ and contraction‐stimulated skeletal muscle glucose uptake	14
Nerve growth factor transfer from cardiomyocytes to innervating sympathetic neurons activates TrkA receptors at the neuro‐cardiac junction	14
Profoundly lower muscle mass and rate of contractile protein synthesis in boys with Duchenne muscular dystrophy	14
Corticoreticulospinal tract neurophysiology in an arm and hand muscle in healthy and stroke subjects	14
How the Hodgkin cycle became the principle of biological relativity	14
Nitrate‐rich beetroot juice ingestion reduces skeletal muscle O2 uptake and blood flow during exercise in sedentary men	14
AMP‐activated protein kinase activator AICAR attenuates hypoxia‐induced murine fetal growth restriction in part by improving uterine artery blood flow	14
Opposing modulation of Cx26 gap junctions and hemichannels by CO2	14
Daily changes in neuronal activities of the dorsal motor nucleus of the vagus under standard and high‐fat diet	14
Subcellular diversity of Nav1.5 in cardiomyocytes: distinct functions, mechanisms and targets	14
Correlating genotype with phenotype using CFTR‐mediated whole‐cell Cl− currents in human nasal epithelial cells	14
Regulation of metabolic health by dietary histidine in mice	14
Insulin‐stimulated glucose uptake partly relies on p21‐activated kinase (PAK)2, but not PAK1, in mouse skeletal muscle	14
Circulating exosome‐like vesicle and skeletal muscle microRNAs are altered with age and resistance training	14
Global REACH 2018: the adaptive phenotype to life with chronic mountain sickness and polycythaemia	14
Temporally‐precise basolateral amygdala activation is required for the formation of taste memories in gustatory cortex	14
The influence of maturation on exercise‐induced cardiac remodelling and haematological adaptation	14
Exertional dyspnoea in patients with mild‐to‐severe chronic obstructive pulmonary disease: neuromechanical mechanisms	14
Neonatal antibiotics have long term sex‐dependent effects on the enteric nervous system	14
An obesogenic diet impairs uncoupled substrate oxidation and promotes whitening of the brown adipose tissue in rats	13