Journal of Physiology-London

Article	Citations
The astrocytic Na+‐HCO3− cotransporter, NBCe1, is dispensable for respiratory chemosensitivity	154
Nitric oxide synthase inhibition in healthy adults reduces regional and total cerebral macrovascular blood flow and microvascular perfusion	87
Issue Information	73
Pregnancy does not affect progression of mild experimental asthma in sheep	71
Integrating respiration into sympathetic transduction to blood pressure	68
	57
Goal‐directed action preparation in humans entails a mixture of corticospinal neural computations	55
Magnesium sulphate reduces tertiary gliosis but does not improve EEG recovery or white or grey matter cell survival after asphyxia in preterm fetal sheep	53
Issue Information	53
Why you should pay more attention to your cells’ sex	52
In Memoriam: Ann Silver	51
Action potentials in postganglionic sympathetic nerves depend on NaV1.7	51
Issue Information	46
The endocrine kidney: tampering with oxygen sensors may change your character	46
Ocular surface information seen from the somatosensory thalamus and cortex	45
A more holistic view could contribute to our understanding of ‘silent hypoxaemia’ in Covid‐19 patients	43
Issue Information	43
Cerebral uptake of microvesicles occurs in normocapnic but not hypocapnic passive hyperthermia in young healthy male adults	42
Reply to ‘Reevaluating central versus peripheral contributions to maximal oxygen uptake: the role of muscle diffusive capacity’	41
The ups and downs of intermittent hypoxia as a therapy for ventilatory insufficiency	41
Motor learning changes the axon initial segment of the spinal motoneuron	39
CrossTalk rebuttal	39
Augmenting workload drives T‐tubule assembly in developing cardiomyocytes	38
Severe hypoxaemic hypercapnia compounds cerebral oxidative–nitrosative stress during extreme apnoea: Implications for cerebral bioenergetic function	37
Unveiling sex differences in skeletal muscle metabolism: the role of HIF1α in normoxia	36

Activation of the myosin motors in fast‐twitch muscle of the mouse is controlled by mechano‐sensing in the myosin filaments	36
Determinants and therapeutic potential of calcium handling abnormalities in atrial fibrillation: what can we learn from computer models?	36
Changes in intra‐ and interlimb reflexes from forelimb cutaneous afferents after staggered thoracic lateral hemisections during locomotion in cats	36
Melanin‐concentrating hormone‐producing neurons in the hypothalamus regulate brown adipose tissue and thus contribute to energy expenditure	35
Stroke severity shapes extracellular vesicle profiles and their impact on the cerebral endothelial cells	35
Allosteric modulation of cardiac myosin mechanics and kinetics by the conjugated omega‐7,9 trans‐fat rumenic acid	35
Decoding platelet loss in the hypoxic brain: What could go wrong?	35
‘Evolutionary poker’: an agent‐based model of interactome emergence and epistasis tested against Lenski's long‐term E. coli experiments	35
Corticothalamic modulation of somatosensory thalamic tactile processing	35
Opening the door to physiological impacts underlying opioid‐induced respiratory depression and therapeutic strategies: focus on fentanyl	33
Lack of compensatory mitophagy in skeletal muscles during sepsis	33
The 70‐year search for the voltage‐sensing mechanism of ion channels	32
Peripheral chemoreflex restrains skeletal muscle blood flow during exercise in participants with treated hypertension	32
Hypertension increases sympathetic neuron activity by enhancing intraganglionic cholinergic collateral connections	32
Diversity of cells and signals in the cardiovascular system	31
CKAMP44 controls synaptic function and strength of relay neurons during early development of the dorsal lateral geniculate nucleus	31
Diarrhoeal pathogenesis in Salmonella infection may result from an imbalance in intestinal epithelial differentiation through reduced Notch signalling	31
Chronic intermittent hypoxia‐induced cardiovascular and renal dysfunction: from adaptation to maladaptation	31
Mitochondrial carbonic anhydrase VA and VB: properties and roles in health and disease	30
Back‐seat driver: the fetus is not a passive passenger!	30
Sensorimotor integration within the primary motor cortex by selective nerve fascicle stimulation	30
Heartbeat‐related activity in the anterior thalamus differs between phasic and tonic REM sleep	30
Issue Information	30
An experiment of nature links muscle glycogen unavailability with very high fat oxidation rates despite low aerobic fitness	29
Issue Information	29
Situating physiology within evolutionary theory	29
Too hot to handle? Unveiling gut permeability during exertional heat stress	28
Reply from D. R. Perkins and Mike Stembridge	28
Towards unravelling the exercise‐induced adaptations in circulating extracellular vesicles	28
Sexual dimorphism: increased sterol excretion leads to hypocholesterolaemia in female hyperbilirubinaemic Gunn rats	28
Issue Information	28
Want to hear ClC‐6 sing? Push your amp to eleven	28
Issue Information	27
Macrophage microvesicle‐derived circ_YTHDF2 in methamphetamine‐induced chronic lung injury	27
Response to ‘Comment on Wyrwoll et al., 2022: Long‐term exposure of mice to 890 ppm atmospheric CO2 alters growth trajectories and hyperactive behaviours in adults’ by Norman R. Saunders an	27
	27
Unravelling the mysteries of mitochondria in health and disease	27
The non‐invasive assessment of muscle fibre size: has the future arrived?	27
Making ‘sense’ of what happens on the inside: il‘LUMEN'ating the effects of intestinal distention on calcium activity in enteric neurons	27
Insulin potentiates the response to capsaicin in dorsal root ganglion neurons in vitro and muscle afferents ex vivo in normal healthy rodents	27
Multi‐scale modelling of the effects of ageing, hypertension and exercise on the cerebral vasculature	26
Volitional exercise elicits physiological and molecular improvements in the severe D2.mdx mouse model of Duchenne muscular dystrophy	26
Extracellular vesicles and their non‐coding RNA cargos: Emerging players in cardiovascular disease	26
A cross‐species validation of single‐beat metrics of cardiac contractility	26
Hyperglycaemia, pregnancy outcomes and maternal metabolic disease risk during pregnancy and lactation in a lean gestational diabetes mouse model	26
Loss of the alpha subunit distal furin cleavage site blunts ENaC activation following Na+ restriction	25
Multispectral brain connectivity during visual attention distinguishes controlled from uncontrolled hypertension	25
Hypoxic sensitivity and burden predict propensity for respiratory plasticity in humans	25
Optical mapping of contracting hearts	25
Properties and modulation of excitatory inputs to the locus coeruleus	24

Ageing reduces persistent inward current contribution to motor neurone firing: Potential mechanisms and the role of exercise	24
The neural control of movement: a century of in vivo motor unit recordings is the legacy of Adrian and Bronk	24
Inflammatory gene expression during acute high‐altitude exposure	24
Corrigendum	23
The fallacy of functional nomenclature in the kingdom of biological multifunctionality: physiological and evolutionary considerations on ion channels	23
Efficiency of cycling exercise: Understanding the physiology	23
Speciation by physiological selection of environmentally acquired traits	23
Glucocorticoids regulate mitochondrial fatty acid oxidation in fetal cardiomyocytes	23
Presynaptic H3 receptor: A modulator for CeL excitatory‐inhibitory homeostasis	23
Synaptic loss in motor neurons precipitates age‐related dysphagia: Middle agers gotta keep in touch!	23
Thermodynamic limitations on brain oxygen metabolism: physiological implications*	23
Muscle déjà vu: are myonuclei the blueprint for muscle regrowth?	23
Muscle matters: exploring the contributions of ageing skeletal muscle to metabolic syndrome	23
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Release your inhibitions: The role of post‐inhibitory rebound and synaptic inhibition in the generation of expiratory activity	23
Functional development and regeneration of hair cells in the zebrafish lateral line	22
Action potential amplitude and baroreflex resetting of action potential clusters mediate hypoxia‐induced sympathetic long‐term facilitation	22
Bioavailable testosterone and androgen receptor activation, but not total testosterone, are associated with muscle mass and strength in females	22
Muscarinic regulation of the neuronal Na+/K+‐ATPase in rat hippocampus	22
Past questions, present results, future perspectives: Interacting chemosensitive areas and the hypercapnic ventilatory response	21
Cathodal bilateral transcranial direct‐current stimulation regulates selenium to confer neuroprotection after rat cerebral ischaemia–reperfusion injury	21
Fast and sensitive GCaMP calcium indicators for neuronal imaging	21
Who's on first … Na+, HCO3− or CO32−?	21
Glyoxalase 1 overexpression improves neurovascular coupling and limits development of mild cognitive impairment in a mouse model of type 1 diabetes	21
Issue Information	21
Something's fishy: cardiovascular ATP‐sensitive K+ channels in zebrafish	21
The diverse functions of the DEG/ENaC family: linking genetic and physiological insights	21
Issue Information	21
Muscular strength, endothelial function and cognitive disorders: state of the art	21
The key to our hearts: Unlocking fundamental sex differences in mouse cardiomyocyte calcium‐cycling	21
The potential therapeutic benefits of low frequency haemodynamic oscillations	21
Function of K2P channels in the mammalian node of Ranvier	21
Hydrogen peroxide and phosphoinositide metabolites synergistically regulate a cation current to influence neuroendocrine cell bursting	21
Intrinsic motoneuron properties in typical human development	20
Adrenergic restraint of blood flow and high‐altitude acclimatization	20
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Mechano‐electrical interactions and heterogeneities in wild‐type and drug‐induced long QT syndrome rabbits	20
Crosstalk between biochemical signalling network architecture and trafficking governs AMPAR dynamics in synaptic plasticity	20
Central α2‐adrenergic mechanisms regulate human sympathetic neuronal discharge strategies	20
Translating physiology of the arterial chemoreflex into novel therapeutic interventions targeting carotid bodies in cardiometabolic disorders	20
Circadian patterns of heart rate variability in fetal sheep after hypoxia‐ischaemia: A biomarker of evolving brain injury	20
Reduced plakoglobin increases the risk of sodium current defects and atrial conduction abnormalities in response to androgenic anabolic steroid abuse	20
A systematic review of computational models for the design of spinal cord stimulation therapies: from neural circuits to patient‐specific simulations	19
Identification of a helix–turn–helix motif for high temperature dependence of vanilloid receptor TRPV2	19
A detailed mathematical model of the human atrial cardiomyocyte: integration of electrophysiology and cardiomechanics	19
Novel regenerative drug, SPG302 promotes functional recovery of diaphragm muscle activity after cervical spinal cord injury	19
Encoding of vestibular and optic flow cues to self‐motion in the posterior superior temporal polysensory area	19
Reorganization of mitochondria–organelle interactions during postnatal development in skeletal muscle	19
Nav1.2 and BK channel interaction shapes the action potential in the axon initial segment	19
Towards spatially selective efferent neuromodulation: anatomical and functional organization of cardiac fibres in the porcine cervical vagus nerve	19
TET2 confers a mechanistic link of microRNA‐210 and mtROS in hypoxia‐suppressed spontaneous transient outward currents in uterine arteries of pregnant sheep	19
The effects of local vibration inducing a tonic vibration reflex or movement illusion on acute modulations of corticospinal excitability	19
Ageing impairs endothelium‐dependent vasodilatation and alters redox signalling in diaphragm arterioles from male and female Fischer‐344 rats	19
Oncomodulin regulates spontaneous calcium signalling and maturation of afferent innervation in cochlear outer hair cells	19
CPT1C is required for synaptic plasticity and oscillatory activity that supports motor, associative and non‐associative learning	18
An automated respiratory data pipeline for waveform characteristic analysis	18
Pump up the volume: breathing facilitates cardiac output during exercise by mechanical action	18
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Beeting atrophy: dietary nitrate to protect the powerhouse of the cell?	18
Use it or lose it: protecting ageing muscles with lifelong recreational exercise	18
A game of chest: Where does blood volume shift?	18
Single muscle fibre contractile characteristics with lifelong endurance exercise	18
Maternal sleep behaviours preceding fetal heart rate events on cardiotocography	18
Characterizing the effects of type I collagen alterations on respiratory function in mouse models with varying severity of osteogenesis imperfecta	18
The cardiac sodium channel from function to dysfunction	18
Revisiting the limitation to with ageing: is mitochondrial (dys)function the key?	18
Ketogenic diet and ketone salts differentially improve cardiometabolic complications in an HFpEF rat model	17
Adenine nucleotide translocator and ATP synthase cooperate in mediating the mitochondrial permeability transition	17
Particle‐swarm based modelling reveals two distinct classes of CRHPVN neurons	17
Exercise intolerance in pulmonary hypertension: robbing Peter to pay Paul	17
The time is now: regular exercise maintains vascular health in ageing women	17
The pathological blood flow steal phenomenon limits exercise tolerance in pulmonary hypertensive rats	17
Issue Information	17
Whole‐body metabolic rate is influenced by muscle fibre typology	17
Critical molecular outcomes of time‐restricted feeding during ageing: a look beyond body composition	17
The complexity of Nrf2 in experimental autoimmune myositis‐induced mice	17
Cross Talk proposal: Human‐derived brain tissue is a better epilepsy model than animal‐based approaches	16
Activating thermogenesis to combat obesity: hot topic or cold front?	16
Rebuttal from Amy Richardson and Gareth Morris	16
Exercise affects fatty acid oxidation and lipid droplets in patients with type 2 diabetes	16

Ca2+ signalling in interstitial cells of Cajal contributes to generation and maintenance of tone in mouse and monkey lower oesophageal sphincters	16
The post‐arteriole transitional zone: a specialized capillary region that regulates blood flow within the CNS microvasculature	16
Enter Sandman: An eye opening opinion of cardiovascular disease prevention in cervical spinal cord injury	16
Expiratory flow limitation during exercise: why does it ‘suck’ so much?	16
The legacy of A. V. Hill's Nobel Prize winning work on muscle energetics	16
The vascular response to acute hyperglycaemia: What is the role of exercise capacity?	16
Issue Information	16
Insulin, Nobel laureates and The Journal of Physiology	16
Neural coordination of bilateral hand movements: evidence for an involvement of brainstem motor centres	16
The complex function of macrophages and their subpopulations in metabolic injury associated fatty liver disease	16
Issue Information	16
Muscle–fat crosstalk: effects of exercise on brown adipose tissue; what do we know?	16
When right ventricular pressure meets volume: The impact of arrival time of reflected waves on right ventricle load in pulmonary arterial hypertension	16
Ubiquitin ligase signalling networks shape presynaptic development, function and disease	16
Fasting and the short‐term consumption of a ketogenic diet are sufficient interventions to protect against OLZ‐induced hyperglycaemia in mice	16
Exosomes and the cardiovascular system: role in cardiovascular health and disease	16
Flex and flow: are we receptive to all females in muscle physiology research?	16
Neuroinflammation and the immune system in hypoxic ischaemic brain injury pathophysiology after cardiac arrest	16
Comparison of excitation–contraction coupling between Drosophila and vertebrate muscle	15
Issue Information	15
Issue Information	15
Presynaptic quantal size enhancement counteracts post‐tetanic release depression	15
Beyond the madness: a balanced approach to standardization, practicality and innovation in exercise physiology threshold assessment	15
Scale‐invariant changes in corticospinal excitability reflect multiplexed oscillations in the motor output	15
Profoundly lower muscle mass and rate of contractile protein synthesis in boys with Duchenne muscular dystrophy	15
Channelling protons out of the heart	15
Loss of anoctamin 1 reveals a subtle role for BK channels in lymphatic muscle action potentials	15
Fluorescent biosensor imaging meets deterministic mathematical modelling: quantitative investigation of signalling compartmentalization	15
Autonomic modulation with mindfulness‐based stress reduction in chronic kidney disease: a randomized controlled trial	15
A multimodal exercise countermeasure prevents the negative impact of head‐down tilt bed rest on muscle volume and mitochondrial health in older adults	15
Vaping for two: unravelling the mysteries of E‐cigarettes and fetal vascular health	15
Phase‐dependent local brain states determine the impact of image‐guided transcranial magnetic stimulation on motor network electroencephalographic synchronization	15
Activation of TRPA1 and TRPM3 triggers Ca2+ waves in central terminals of sensory neurons and facilitates synaptic activity in the spinal dorsal horn	15
Issue Information	15
Evolution of rod bipolar cells and rod vision	15
What is fetal growth restriction and how might we know?	15
Cardiac programming in the placentally restricted sheep fetus in early gestation	15
High altitude differentially modulates potassium channel‐evoked vasodilatation in pregnant human myometrial arteries	15
Extracellular vesicles and their microRNA cargo in ischaemic stroke	15
Notch1 promotes ordered revascularization through Semaphorin 3g modulation of downstream vascular patterning signalling factors	15
Annual Prize Lecture 2024: Endogenous physiological mechanisms as basis for the treatment of obesity and type 2 diabetes	14
Homeostasis and evolution in relation to regeneration and repair	14
Stem cell approaches for tendon repair: delusion or insight	14
Paraventricular nucleus projections to the nucleus tractus solitarii are essential for full expression of hypoxia‐induced peripheral chemoreflex responses	14
Recurrence of ventricular fibrillation in out‐of‐hospital cardiac arrest: Clinical evidence and underlying ionic mechanisms	14
Enhancing stroke risk stratification in atrial fibrillation through non‐Newtonian blood modelling and Gaussian process emulation	14
Metformin in pregnancy: a re‐examination of its safety	14
Mitochondrial calcium: An essential element for skeletal muscle performance and function	14
Becoming mindful of mindfulness: a promising approach to reducing sympathetic nervous system overactivity in chronic kidney disease	14
Physiological mechanisms of unexplained (functional) gastrointestinal disorders	14
Exercise, healthy ageing, and the potential role of small extracellular vesicles	14
Oxytocin and corticotropin‐releasing hormone exaggerate nucleus tractus solitarii neuronal and synaptic activity following chronic intermittent hypoxia	14
Plasma measurements of the dual sugar test reveal carbohydrate immediately alleviates intestinal permeability caused by exertional heat stress	14
Interstitial cells of Cajal – pacemakers of the gastrointestinal tract	14
Adaptive spike threshold dynamics associated with sparse spiking of hilar mossy cells are captured by a simple model	14
How neural networks walk and chew gum	14
Directional sensitivity of C‐low‐threshold mechanoreceptors: insights from in vivo calcium imaging	14
Endurance exercise training changes the limitation on muscle V̇O2max${\dot{V}}_{{{\mathrm{O}}}_{\mathrm{2}}{\mathrm{max}}}$ in normoxia from the capacity to utilize O2 to the capacity to tr	14
A narrative review of periodic breathing during sleep at high altitude: From acclimatizing lowlanders to adapted highlanders	14
Time course and fibre type‐dependent nature of calcium‐handling protein responses to sprint interval exercise in human skeletal muscle	14
Late gestation fetal hyperglucagonaemia impairs placental function and results in diminished fetal protein accretion and decreased fetal growth	14
Muscle‐derived IL‐1β regulates EcSOD expression via the NBR1‐p62‐Nrf2 pathway in muscle during cancer cachexia	14
Disrupted T‐tubular network accounts for asynchronous calcium release in MTM1‐deficient skeletal muscle	14
Can muscle typology explain the inter‐individual variability in resistance training adaptations?	14
Mutation protocols share with sexual reproduction the physiological role of producing genetic variation within ‘constraints that deconstrain’	13
Functions require junctions: endurance exercise protects from age‐induced alterations of the neuromuscular system	13
Comprehensive measurement of muscle maximal oxygen uptake determinants: insights and application	13
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Issue Information	13
Bile acid‐ and ethanol‐mediated activation of Orai1 damages pancreatic ductal secretion in acute pancreatitis	13
The role of female sex hormones and oral combined contraceptives in metabolic adaptations	13
Cerebral blood flow regulation in hypobaric hypoxia: role of haemoconcentration	13
Differential signalling induced by α7 nicotinic acetylcholine receptors in hippocampal dentate gyrus in vitro and in vivo	13
Early heart and skeletal muscle mitochondrial response to a moderate hypobaric hypoxia environment	13
Motoneuron excitability dysfunction in ALS: Pseudo‐mystery or authentic conundrum?	13
Inhibition and potentiation of the exercise pressor reflex by pharmacological modulation of TRPC6 in male rats	13
Channelling calcium signals to therapeutics	13
Using exercise training to improve glycaemic control and uncover mechanisms of impaired skeletal muscle in type 1 diabetics	13
A revised mechanism of action of hyperaldosteronism‐linked mutations in cytosolic domains of GIRK4 (KCNJ5)	13
A very brief note on why bacterial evolution has physiology	13
Issue Information	13
ER‐Ca2+ stores and the regulation of store‐operated Ca2+ entry in neurons	13
Computational framework for the generation of one‐dimensional vascular models accounting for uncertainty in networks extracted from medical images	13
The alarmin, interleukin‐33, increases vascular tone via extracellular signal regulated kinase‐mediated Ca2+ sensitization and endothelial nitric oxide synthase inhibition	13
School of ‘hard NOX’ for the ageing artery	13
Understanding the hypothalamic–brainstem bridge in the hypoxia puzzle	13
Skeletal muscle mitochondria in strength athletes: meeting energy needs with mitochondrial morphological changes	13
Exercise snacks: a novel approach to address firefighter occupational cancer	13
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BK channels at dendritic spines: A mechanism for coupling morphology, plasticity and information storage?	13
Pedalling toward a deeper understanding of exercise effects on immune function	13
The association between pain‐induced autonomic reactivity and descending pain control is mediated by the periaqueductal grey	12
Slowly‐adapting type II afferents contribute to conscious touch sensation in humans: Evidence from single unit intraneural microstimulation	12
In Memoriam: Gary Mawe	12
Vestibular contribution to motor output is also suppressed by voluntary action of the arm	12