Journal of Physiology-London

Article	Citations
Issue Information	110
Severe acute hypoxia impairs recovery of voluntary muscle activation after sustained submaximal elbow flexion	107
The sloppy relationship between neural circuit structure and function	74
Synergistic interaction of nerve growth factor and glial cell‐line derived neurotrophic factor in muscular mechanical hyperalgesia in rats	64
A physiological model of the inflammatory‐thermal‐pain‐cardiovascular interactions during an endotoxin challenge	58
An obesogenic diet impairs uncoupled substrate oxidation and promotes whitening of the brown adipose tissue in rats	53
New insights into heart failure during this challenging time	49
Issue Information	48
Cardiorespiratory and autonomic adjustments to exercise with healthy ageing: considerations with extreme heat exposure and hydration	47
In Memoriam: Ann Silver	46
Cortical coding of gustatory and thermal signals in active licking mice	45
	45
From human to superhuman: the impact of the microbiome on physiology	43
Swift energy shift: Acute exercise reduces cerebral glucose metabolism in cognitively healthy older adults and individuals with Alzheimer's disease	42
Integrating respiration into sympathetic transduction to blood pressure	42
Dendritic alterations precede age‐related dysphagia and nucleus ambiguus motor neuron death	41
Functional knockout of the TRPV1 channel has no effect on the exercise pressor reflex in rats	39
Small peptides: could they have a big role in metabolism and the response to exercise?	37
Molecular permeation through large pore channels: computational approaches and insights	36
Silences, spikes and bursts: Three‐part knot of the neural code	35
Biogenesis and reformation of synaptic vesicles	34
Parkin: a potential target to promote healthy ageing	34
Brainstem astrocytes control homeostatic regulation of caloric intake	33
Acute and prolonged competing effects of activation history on human motor unit firing rates during contractile impairment and recovery	33
Exposure to high fructose corn syrup during adolescence in the mouse alters hepatic metabolism and the microbiome in a sex‐specific manner	32

Issue Information	31
Issue Information	31
Rebuttal from Manoja K. Brahma, Adam R. Wende and Kyle S. McCommis	30
	29
Diversity of cells and signals in the cardiovascular system	29
Macrophage plasticity in Duchenne muscular dystrophy: a nexus of pathological remodelling with therapeutic implications	29
Determinants and therapeutic potential of calcium handling abnormalities in atrial fibrillation: what can we learn from computer models?	28
The 70‐year search for the voltage‐sensing mechanism of ion channels	28
Antagonism of TRPV4 channels partially reduces mechanotransduction in rat skeletal muscle afferents	28
Carbohydrate improves exercise capacity but does not affect subcellular lipid droplet morphology, AMPK and p53 signalling in human skeletal muscle	28
Are Hodgkin cycles everywhere?	27
Two epilepsy‐associated variants in KCNA2 (KV1.2) at position H310 oppositely affect channel functional expression	27
Regulation of PKD2 channel by TACAN: how does it link to cystogenesis in autosomal dominant polycystic kidney disease?	27
	26
The PoWeR of exercise: Exploring the anti‐ageing effects of exercise through epigenetic modifications to skeletal muscle	26
Can lizards become alligators? Muscle fibre type and other factors that may influence (or not) hypertrophy responsiveness after resistance training	26
Prescribing reduced physical activity following volumetric muscle loss not really a good idea	26
Issue Information	25
Issue Information	25
Issue Information	25
Insight on novel mechanisms mediating the generation of inflammatory pain in somatosensory neurons	25
Reply from George A. Brooks, Harry B. Rossiter, David C. Poole and L. Bruce Gladden	25
Chasing the hunger‐suppressive signals of human exercise	25
The missing ‘link’? β‐Catenin's role in skeletal muscle glucose uptake during exercise and contraction	25
Elucidation of a proposed cardiorespiratory circadian rhythm impacting survival in SUDEP	25
Soleus responses to Achilles tendon stimuli are suppressed by heel and enhanced by metatarsal cutaneous stimuli during standing	25
The endocrine kidney: tampering with oxygen sensors may change your character	24
Regional associations between inspiratory tongue dilatory movement and genioglossus activity during wakefulness in people with obstructive sleep apnoea	24
Late sodium current: incomplete inactivation triggers seizures, myotonias, arrhythmias, and pain syndromes	24
Death by hypoxia: what were they thinking?	24
Ketone body oxidation: glycogen‐sparing yet glucose‐dependent?	24
	24
Cerebral uptake of microvesicles occurs in normocapnic but not hypocapnic passive hyperthermia in young healthy male adults	23
Enhanced slow inactivation contributes to dysfunction of a recurrent SCN2A mutation associated with developmental and epileptic encephalopathy	23
Co‐activation of GPCRs facilitate GIRK‐dependent current	23
Ocular surface information seen from the somatosensory thalamus and cortex	22
Myo‐inositol alters the effects of glucose, leptin and insulin on placental palmitic acid and oleic acid metabolism	22
Implications of a patent foramen ovale for environmental physiology and pathophysiology: do we know the ‘hole’ story?	22
Issue Information	22
Passive muscle heating attenuates the decline in vascular function caused by limb disuse	22
CKAMP44 controls synaptic function and strength of relay neurons during early development of the dorsal lateral geniculate nucleus	22
Anticipatory stress: a model to study cardiovascular and sympathetic responses to mental stress?	21
Improving skeletal muscle insulin sensitivity via beta2‐agonist administration: a promising strategy to counteract metabolic disease and muscle loss	21
A more holistic view could contribute to our understanding of ‘silent hypoxaemia’ in Covid‐19 patients	21
GABAB‐ and GABAA‐receptor‐mediated regulation of Up and Down states across development	21
The muscle clock: how does muscle physiology change in 24 h in response to exercise?	21
Histone‐mediated skeletal muscle adaptations to exercise: insights into a new era of epigenome‐based personalized medicine	21
When fat meets the engine: implications of dietary rumenic acid on myosin‐targeting therapies in heart failure	21
Tail of two fishies: age and afferents influence zebrafish lateral‐line hair cell regeneration	20
SIRT1 induction in the skeletal muscle of male mice partially preserves limb muscle mass but not contractile force in response to androgen deprivation	20

Issue Information	20
	20
Logarithmically scaled, gamma distributed neuronal spiking	20
The significance of the loss of presynaptic inhibition for step initiation in parkinsonian individuals with freezing of gait	20
Regulation of PKD2 channel function by TACAN	20
Maternal obesity: influencing the heart right from the start	20
Allosteric modulation of cardiac myosin mechanics and kinetics by the conjugated omega‐7,9 trans‐fat rumenic acid	20
Seventy years later: the legacy of the Hodgkin and Huxley model in computational neuroscience	19
KLB dysregulation mediates disrupted muscle development in intrauterine growth restriction	19
Transcranial direct current stimulation to enhance athletic performance: Are we there yet? Will we ever get there?	19
Squeezing viscous blood through narrow pipes, and other problems of high‐altitude polycythaemia	19
Can exercise prevent the age‐related decline in adaptive homeostasis? Evidence across organisms and tissues	19
Functional reserve and sex differences during exercise to exhaustion revealed by post‐exercise ischaemia and repeated supramaximal exercise	19
Direct intraoperative measurement of isometric contractile properties in living human muscle	19
Excitatory action of low frequency depolarizing GABA/glycine synaptic inputs is prevalent in prenatal spinal SOD1G93A motoneurons	19
Issue Information	19
How long is too long? No added benefit with prolonged ventilation with intact cord in preterm infants	19
Does COVID‐19 influence the sympathetic regulation of blood pressure?	19
Sensorimotor integration within the primary motor cortex by selective nerve fascicle stimulation	19
Reply to ‘Letter to the editor: is maximal diaphragm tissue velocity suited for the assessment of diaphragm contractility?’	19
Putting the HYPE in hypertension: peripheral chemoreflex constraint of skeletal muscle blood flow	19
CRAC channel inhibitors in pancreatic pathologies	19
Reduction of left ventricular diastolic pressure as a key regulator of infarct coronary flow under mechanical left ventricular support	18
Physiology in Central and South America and hope for better times	18
Use of a physiological profile to document upper limb motor impairment in ageing and in neurological conditions	18
Issue Information	18
Enhancing the dark side: asymmetric gain of cone photoreceptors underpins their discrimination of visual scenes based on skewness	18
A no brainer: intervening early to protect against perinatal brain injury	18
Ion channels and transporters keep ideas flowing	18
‘Evolutionary poker’: an agent‐based model of interactome emergence and epistasis tested against Lenski's long‐term E. coli experiments	18
Why you should pay more attention to your cells’ sex	18
Resting membrane potential and intracellular [Na+] at rest, during fatigue and during recovery in rat soleus muscle fibres in situ	18
Combination of chemotherapy and antioxidants: promising therapeutic strategies for muscle atrophy during cancer treatment	18
Regulation of Orai channels by intracellular pH: one step closer to understanding CRAC channel biology?	18
	18
Blunted cerebrovascular CO2 reactivity to satisfy the hungry heat stressed brain	18
Issue Information	18
Is the exercise pressor reflex under pressure?	18
	18
Closing in on the heat‐activation mechanisms of TRPV channels	18
Effect of vitamin C infusion on altitude‐related vasodilatory dysfunction	18
Pitfalls of using sequence databases for heterologous expression studies – a technical review	18
Lack of compensatory mitophagy in skeletal muscles during sepsis	17
Axonal excitability changes in children with spinal muscular atrophy treated with nusinersen	17
Issue Information	17
Has the importance of GABAA presynaptic inhibition been overestimated in human motor control?	17
Issue Information	17
Chemoreceptor mechanisms regulating CO2‐induced arousal from sleep	17
Fast A‐type currents shape a rapidly adapting form of delayed short latency firing of excitatory superficial dorsal horn neurons that express the neuropeptide Y Y1 receptor	17
How high can the lactate phoenix rise?	17
Opening the door to physiological impacts underlying opioid‐induced respiratory depression and therapeutic strategies: focus on fentanyl	17
Probing the interstitial calcium compartment	17
Muscle glycogen depletion: a weak‐link rendering muscle cells prone to potassium‐induced fatigue?	17
Understanding the role of sirtuin 1 in muscle physiology during androgen deprivation	17
	17
	17
Dynamics of cardio‐muscular networks in exercise and fatigue	17
THRIFTY: a novel high‐throughput method for rapid fibre type identification of isolated skeletal muscle fibres	16
Morphine‐induced mechanical hypersensitivity in mice requires δ receptors, β‐arrestin2, and c‐Src activity	16
Identification of protein kinase A signalling molecules in renal collecting ducts	16
Melanin‐concentrating hormone‐producing neurons in the hypothalamus regulate brown adipose tissue and thus contribute to energy expenditure	16
The astrocytic Na+‐HCO3− cotransporter, NBCe1, is dispensable for respiratory chemosensitivity	16
Distinct mechanisms of CB1 and GABAB receptor presynaptic modulation of striatal indirect pathway projections to mouse globus pallidus	16
The potassium–glycogen interaction on force and excitability in mouse skeletal muscle: implications for fatigue	16
Age and low intensity resistance exercise on exosome‐like vesicle and skeletal muscle microRNA profiles	16
Crosstalk proposal: There is much to gain from the independent control of human muscle spindles	16
Convergent escape behaviour from distinct visual processing of impending collision in fish and grasshoppers	15
Divergent effects of initial ventilation with delayed cord clamping on systemic and pulmonary arterial flows in the birth transition of preterm lambs	15
Is it time to expand the scope of the autonomic nervous system?	15
Regulation of metabolic health by dietary histidine in mice	15
The gut–muscle axis shapes exercise performance	15
Dynamic encoding of saccade sequences in primate frontal eye field	15
Mitochondrial carbonic anhydrase VA and VB: properties and roles in health and disease	15
	15
A deep analysis of the proteomic and phosphoproteomic alterations that occur in skeletal muscle after the onset of immobilization	15
Hypertension increases sympathetic neuron activity by enhancing intraganglionic cholinergic collateral connections	15
Blockage of aquaporin‐3 peroxiporin activity by organogold compounds affects melanoma cell adhesion, proliferation and migration	15
Fluid and protein exchange in microvascular networks: Importance of modelling heterogeneity in geometrical and biophysical properties	15
EPOtential target for endurance performance: the effect of exogenous ketone supplementation on circulating erythropoietin levels	15
	15

The effects of daily dose of intense exercise on cardiac responses and atrial fibrillation	15
The impact of 60 days of ‐6° head down tilt bed rest on mitochondrial content, respiration and regulators of mitochondrial dynamics	15
Physiological and pathophysiological roles of the KCNK3 potassium channel in the pulmonary circulation and the heart	14
The susceptibility of the rat pulmonary and caval vein myocardium to the catecholamine‐induced ectopy changes oppositely in postnatal development	14
Capillary module haemodynamics and mechanisms of blood flow regulation in skeletal muscle capillary networks: Experimental and computational analysis	14
Chronic intermittent hypoxia remodels catecholaminergic nerve innervation in mouse atria	14
Brief response to Terrar	14
Past the limits of pain: placebo and nocebo effects in visual processing reveal novel behavioural and brain markers of the twin phenomena	14
Human sodium current voltage‐dependence at physiological temperature measured by coupling a patch‐clamp experiment to a mathematical model	14
Recent advances in the structure, function and regulation of the volume‐regulated anion channels and their role in immunity	14
Acid glia provide a synaptic boost	14
Whole genome transcriptomic reveals heat stroke molecular signatures in humans	14
Sowing the seeds of stress: maternal exposure to synthetic glucocorticoids impacts sperm miRNA for generations	14
Orbitofrontal control of the olfactory cortex regulates olfactory discrimination learning	14
Visual placebo and nocebo effects	14
Diarrhoeal pathogenesis in Salmonella infection may result from an imbalance in intestinal epithelial differentiation through reduced Notch signalling	14
Regulation of presynaptic homeostatic plasticity by glial signalling in Alzheimer's disease	14
TRPV1 in arteries enables a rapid myogenic tone	14
	14
EXPRESSION OF CONCERN: Insulin relaxes bladder via PI3K/AKT/eNOS pathway activation in mucosa: unfolded protein response‐dependent insulin resistance as a cause of obesity‐associated overactive bladde	14
Acute oral digoxin in healthy adults hastens fatigue and increases plasma K+ during intense exercise, despite preserved skeletal muscle Na+,K+‐ATPase	14
Late‐gestation maternal undernutrition induces circulatory redistribution while preserving uteroplacental function independent of fetal glycaemic state	14
Calmodulin regulates TRPV5 intracellular trafficking and plasma membrane abundance	14
Mitochondrial respiration is lower in the intrauterine growth‐restricted fetal sheep heart	13
The ups and downs of intermittent hypoxia as a therapy for ventilatory insufficiency	13
Harnessing pericytes to aid muscle recovery after immobilization	13
The mitochondrial calcium uniporter: Balancing tumourigenic and anti‐tumourigenic responses	13
cAMP reduces action potential amplitude and conduction velocity over long axonal distance	13
Optogenetic approaches to therapy for inherited retinal degenerations	13
Calcineurin regulates synaptic Ca2+‐permeable AMPA receptors in hypothalamic presympathetic neurons via α2δ‐1‐mediated GluA1/GluA2 assembly	13
Optimized design of an arterial network model reproduces characteristic central and peripheral haemodynamic waveform features of young adults	13
Bayliss Starling Prize Lecture 2023: Neuropeptide‐Y being ‘unsympathetic’ to the broken hearted	13
Untangling webs of divergent neuroimmune circuits	13
The neurobiological response to intermittent hypoxia: insights into adaptation and resilience	13
Impact of cancer cachexia on respiratory muscle function and the therapeutic potential of exercise	13
Role of CFTR in diabetes‐induced pancreatic ductal fluid and HCO3− secretion	13
	13
Physiological determinants of mechanical efficiency during advanced ageing and disuse	13
Rebuttal from Nickole Moon, Christopher Morgan and Tracy L. Bale	13
Reflections on reflected waves in ‘YoungAdult’	13
Action potentials in postganglionic sympathetic nerves depend on NaV1.7	13
The benefits of physical activity on neuromuscular structure and function in old age	13
Time restricted feeding plus exercise: could two be better than one for metabolic health?	13
Early resistance training‐mediated stimulation of daily muscle protein synthetic responses to higher habitual protein intake in middle‐aged adults	12
Molecular and cellular neurocardiology in heart disease	12
Somatostatin modulation of initial fusion pores in Ca2+‐triggered exocytosis from mouse chromaffin cells	12
Multiple layers of diversity govern the cell type specificity of GABAergic input received by mouse subicular pyramidal neurons	12
Intracerebroventricular insulin injection acutely normalizes the augmented exercise pressor reflex in male rats with type 2 diabetes mellitus	12
Non‐invasive estimation of muscle fibre size from high‐density electromyography	12
Distinguishing pathophysiological features of heart failure with reduced and preserved ejection fraction: A comparative analysis of two mouse models	12
Ion‐channel degeneracy and heterogeneities in the emergence of complex spike bursts in CA3 pyramidal neurons	12
Persistence of quantal synaptic vesicle recycling in virtual absence of dynamins	12
Sex differences in human performance	12
HFrEF and HFpEF: are mitochondria at the heart of the matter?	12
All‐optical monitoring of excitation–secretion coupling demonstrates that SV2A functions downstream of evoked Ca2+ entry	12
Human performance augmentation: the importance of integrative physiological quantification	12
Regulation of cerebral blood flow by arterial PCO2 independent of metabolic acidosis at 5050 m	12
Correlation networks of spinal motor neurons that innervate lower limb muscles during a multi‐joint isometric task	12
On the role of skeletal muscle acidosis and inorganic phosphates as determinants of central and peripheral fatigue: A 31P‐MRS study	12
Activation of LH GABAergic inputs counteracts fasting‐induced changes in tVTA/RMTG neurons	12
Mitochondria dysfunction in the failing right heart: what is the potential therapeutic target?	12
Chronic intermittent hypoxia‐induced cardiovascular and renal dysfunction: from adaptation to maladaptation	12
Increased pyramidal and VIP neuronal excitability in rat primary auditory cortex directly correlates with tinnitus behaviour	12
Ageing attenuates exercise‐enhanced motor cortical plasticity	12
Chemosensory cells in the respiratory tract as crucial regulators of innate immune responses	12
Conserved mammalian muscle mechanics during eccentric contractions	12
Continuous long‐term recording and triggering of brain neurovascular activity and behaviour in freely moving rodents	12
Bile acids, bioactive signalling molecules in interoceptive gut‐to‐brain communication	12
A tribute to Dr Frederick Sachs	11
The role of ganglionic plexi neurons in atrial fibrillation following spinal cord injury	11
Firing properties of single axons with cardiac rhythmicity in the human cervical vagus nerve	11
Madness or progress? The dilemma of standardizing exercise physiology thresholds	11
In Memoriam: Marcello Costa (1940–2024) – a pioneer of the enteric nervous system	11
A new sympathetic understanding of exercise blood flow regulation in heart failure with preserved ejection fraction	11
	11
Current limitations and future opportunities of tracer studies of muscle ageing	11
Sex differences in lipid metabolism may explain disparities in cardiometabolic disease prevalence with sleep apnoea	11
Testosterone and androgen receptors in females: what is possible with resistance training?	11
Regulation of ClC‐K/barttin by endocytosis influences distal convoluted tubule hyperplasia	11
A proline‐tyrosine motif, endocytosis and low salt – how to link protein functions to organ physiology	11
Advancing respiratory–cardiovascular physiology with the working heart–brainstem preparation over 25 years	11
Correction to ‘Neuronal activity patterns in microcircuits of the cerebellar cortical C3 zone during reaching’	11
Conjunctive processing of spatial border and locomotion in retrosplenial cortex during spatial navigation	11
Decoding platelet loss in the hypoxic brain: What could go wrong?	11
Contribution of transient receptor potential vanilloid 1 (TRPV1) channel to cholinergic contraction of rat bladder smooth muscle	11
	11
Suppression of inflammatory macrophages reduces atherosclerosis	11
CaM‐dependent modulation of human CaV1.3 whole‐cell and single‐channel currents by C‐terminal CaMKII phosphorylation site S1475	11
Functional characterization of PIEZO1 in distinct macrophage populations	11
A multiscale predictive digital twin for neurocardiac modulation	11
Rigour and reproducibility redux	11
Enhancing muscle and brain resilience: The role of prehabilitative exercise in mitigating disuse effects	11
The art of blinding in human physiological research: unmasking the hidden hero in scientific inquiry	11
Biochemical and structural basis of the passive mechanical properties of whole skeletal muscle	11
Avalanche burial pathophysiology – a unique combination of hypoxia, hypercapnia and hypothermia	11