Journal of Physiology-London

Article	Citations
Issue Information	207
Issue Information	96
In Memoriam: Ann Silver	85
Issue Information	82
Integrating respiration into sympathetic transduction to blood pressure	73
Issue Information	69
Can heat stress augment the cerebrovascular and neurotrophic benefits of exercise?	65
Heartbeat‐related activity in the anterior thalamus differs between phasic and tonic REM sleep	60
Maternal obesity alters myeloid immune function in the offspring	59
Corticothalamic modulation of somatosensory thalamic tactile processing	59
Decoding platelet loss in the hypoxic brain: What could go wrong?	55
Motor learning changes the axon initial segment of the spinal motoneuron	52
CrossTalk rebuttal	49
Angiotensin‐converting enzyme and exercise adaptations: Genetic variability, pharmacological modulation and future directions	47
Determinants and therapeutic potential of calcium handling abnormalities in atrial fibrillation: what can we learn from computer models?	47
Theoretical analysis of power‐law stress relaxation and calcium‐dependent passive mechanics in cardiac muscle	47
Diversity of cells and signals in the cardiovascular system	45
Pregnancy does not affect progression of mild experimental asthma in sheep	45
Activation of the myosin motors in fast‐twitch muscle of the mouse is controlled by mechano‐sensing in the myosin filaments	43
Peripheral chemoreflex restrains skeletal muscle blood flow during exercise in participants with treated hypertension	43
Opening the door to physiological impacts underlying opioid‐induced respiratory depression and therapeutic strategies: focus on fentanyl	42
‘Evolutionary poker’: an agent‐based model of interactome emergence and epistasis tested against Lenski's long‐term E. coli experiments	42
Hypertension increases sympathetic neuron activity by enhancing intraganglionic cholinergic collateral connections	42
The 70‐year search for the voltage‐sensing mechanism of ion channels	41
High‐frequency electrical tuning and linear filter properties of Knollenorgan electroreceptors of mormyrid electric fish	41

Stroke severity shapes extracellular vesicle profiles and their impact on the cerebral endothelial cells	41
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Mitochondrial haplotype and sex modulate responses to endurance exercise training	40
Ocular surface information seen from the somatosensory thalamus and cortex	40
Ventricular arrhythmogenic remodelling in diet‐induced metabolic syndrome driven by right‐to‐left regional differences in action potential duration and dominant frequency gradients	39
Diarrhoeal pathogenesis in Salmonella infection may result from an imbalance in intestinal epithelial differentiation through reduced Notch signalling	38
Action potentials in postganglionic sympathetic nerves depend on NaV1.7	37
Reply to ‘Reevaluating central versus peripheral contributions to maximal oxygen uptake: the role of muscle diffusive capacity’	36
Cerebral uptake of microvesicles occurs in normocapnic but not hypocapnic passive hyperthermia in young healthy male adults	36
The astrocytic Na+‐HCO3− cotransporter, NBCe1, is dispensable for respiratory chemosensitivity	36
The endocrine kidney: tampering with oxygen sensors may change your character	35
Why you should pay more attention to your cells’ sex	35
Bayliss–Starling Prize Lecture: KATP channel pathophysiology – a whole‐body odyssey	34
The ups and downs of intermittent hypoxia as a therapy for ventilatory insufficiency	34
Uncertainty quantification via polynomial chaos expansion of myocardial fibre orientation and cardiac activation patterns	34
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Engineering the immune and fibrotic response in VML	33
Preferential lactate metabolism in the human brain during exogenous and endogenous hyperlactataemia	33
Lack of compensatory mitophagy in skeletal muscles during sepsis	33
Sensorimotor integration within the primary motor cortex by selective nerve fascicle stimulation	33
Augmenting workload drives T‐tubule assembly in developing cardiomyocytes	33
The impact of androgens on cardiovascular control mechanisms in polycystic ovary syndrome: Recent advances and translational approaches	33
CKAMP44 controls synaptic function and strength of relay neurons during early development of the dorsal lateral geniculate nucleus	33
Severe hypoxaemic hypercapnia compounds cerebral oxidative–nitrosative stress during extreme apnoea: Implications for cerebral bioenergetic function	33
Magnesium sulphate reduces tertiary gliosis but does not improve EEG recovery or white or grey matter cell survival after asphyxia in preterm fetal sheep	32
Unveiling sex differences in skeletal muscle metabolism: the role of HIF1α in normoxia	32
Semaglutide versus caloric restriction‐induced weight loss: insights into effects on skeletal muscle mass and function	32
Changes in intra‐ and interlimb reflexes from forelimb cutaneous afferents after staggered thoracic lateral hemisections during locomotion in cats	32
Chronic intermittent hypoxia‐induced cardiovascular and renal dysfunction: from adaptation to maladaptation	31
Mitochondrial carbonic anhydrase VA and VB: properties and roles in health and disease	31
Issue Information	31
Goal‐directed action preparation in humans entails a mixture of corticospinal neural computations	31
Issue Information	30
Issue Information	30
An experiment of nature links muscle glycogen unavailability with very high fat oxidation rates despite low aerobic fitness	29
Muscle déjà vu: are myonuclei the blueprint for muscle regrowth?	29
Issue Information	29
Response to ‘Comment on Wyrwoll et al., 2022: Long‐term exposure of mice to 890 ppm atmospheric CO2 alters growth trajectories and hyperactive behaviours in adults’ by Norman R. Saunders an	29
Want to hear ClC‐6 sing? Push your amp to eleven	29
Multispectral brain connectivity during visual attention distinguishes controlled from uncontrolled hypertension	28
Reply from D. R. Perkins and Mike Stembridge	28
Too hot to handle? Unveiling gut permeability during exertional heat stress	28
TMEM16A in gastrointestinal and vascular smooth muscle contractility	28
Towards unravelling the exercise‐induced adaptations in circulating extracellular vesicles	28
Muscle matters: exploring the contributions of ageing skeletal muscle to metabolic syndrome	27
Efficiency of cycling exercise: Understanding the physiology	26
The non‐invasive assessment of muscle fibre size: has the future arrived?	26
Volitional exercise elicits physiological and molecular improvements in the severe D2.mdx mouse model of Duchenne muscular dystrophy	26
Making ‘sense’ of what happens on the inside: il‘LUMEN'ating the effects of intestinal distention on calcium activity in enteric neurons	26
Loss of the alpha subunit distal furin cleavage site blunts ENaC activation following Na+ restriction	26

Release your inhibitions: The role of post‐inhibitory rebound and synaptic inhibition in the generation of expiratory activity	26
Speciation by physiological selection of environmentally acquired traits	25
Action potential amplitude and baroreflex resetting of action potential clusters mediate hypoxia‐induced sympathetic long‐term facilitation	25
Hypoxic sensitivity and burden predict propensity for respiratory plasticity in humans	25
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Macrophage microvesicle‐derived circ_YTHDF2 in methamphetamine‐induced chronic lung injury	25
Situating physiology within evolutionary theory	25
The fallacy of functional nomenclature in the kingdom of biological multifunctionality: physiological and evolutionary considerations on ion channels	25
Synaptic loss in motor neurons precipitates age‐related dysphagia: Middle agers gotta keep in touch!	24
Advances in cardiac devices and bioelectronics augmented with artificial intelligence	24
Microglial phagocytosis in epilepsy: Mechanisms and impact	24
Corrigendum	24
From signals to systems: Mapping the complex physiology of cardiorespiratory dynamics with information theory	24
Dietary nitrate supplementation improves age‐associated neuromuscular outcomes: A step towards healthy ageing	24
Thermodynamic limitations on brain oxygen metabolism: physiological implications*	24
Clenbuterol induces lean mass and muscle protein accretion, but attenuates cardiorespiratory fitness and desensitizes muscle β2‐adrenergic signalling	24
Multi‐scale modelling of the effects of ageing, hypertension and exercise on the cerebral vasculature	24
Cathodal bilateral transcranial direct‐current stimulation regulates selenium to confer neuroprotection after rat cerebral ischaemia–reperfusion injury	24
Muscle memory theory: Implications for health, athletic performance and sports integrity	24
Sexual dimorphism: increased sterol excretion leads to hypocholesterolaemia in female hyperbilirubinaemic Gunn rats	24
Issue Information	24
Properties and modulation of excitatory inputs to the locus coeruleus	23
The neural control of movement: a century of in vivo motor unit recordings is the legacy of Adrian and Bronk	23
Optical mapping of contracting hearts	23
Presynaptic H 3 receptor: A modulator for CeL excitatory‐inhibitory homeostasis	23
Insulin potentiates the response to capsaicin in dorsal root ganglion neurons in vitro and muscle afferents ex vivo in normal healthy rodents	23
Hyperglycaemia, pregnancy outcomes and maternal metabolic disease risk during pregnancy and lactation in a lean gestational diabetes mouse model	23
The diverse functions of the DEG/ENaC family: linking genetic and physiological insights	23
Bioavailable testosterone and androgen receptor activation, but not total testosterone, are associated with muscle mass and strength in females	23
Ageing reduces persistent inward current contribution to motor neurone firing: Potential mechanisms and the role of exercise	23
Extracellular vesicles and their non‐coding RNA cargos: Emerging players in cardiovascular disease	23
Fast and sensitive GCaMP calcium indicators for neuronal imaging	22
A cross‐species validation of single‐beat metrics of cardiac contractility	22
Flex and flow: are we receptive to all females in muscle physiology research?	22
The potential therapeutic benefits of low frequency haemodynamic oscillations	22
Inflammatory gene expression during acute high‐altitude exposure	22
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Neural Modulations during the Stretch–Shortening Cycle: The Importance of Movement Velocity and Task Specificity	22
Ketogenic diet and ketone salts differentially improve cardiometabolic complications in an HFpEF rat model	21
Issue Information	21
Nav1.2 and BK channel interaction shapes the action potential in the axon initial segment	21
Beeting atrophy: dietary nitrate to protect the powerhouse of the cell?	21
The pathological blood flow steal phenomenon limits exercise tolerance in pulmonary hypertensive rats	21
Use it or lose it: protecting ageing muscles with lifelong recreational exercise	21
CPT1C is required for synaptic plasticity and oscillatory activity that supports motor, associative and non‐associative learning	21
The key to our hearts: Unlocking fundamental sex differences in mouse cardiomyocyte calcium‐cycling	21
Maternal sleep behaviours preceding fetal heart rate events on cardiotocography	21
A game of chest: Where does blood volume shift?	21
Reorganization of mitochondria–organelle interactions during postnatal development in skeletal muscle	20
A detailed mathematical model of the human atrial cardiomyocyte: integration of electrophysiology and cardiomechanics	20
The effects of local vibration inducing a tonic vibration reflex or movement illusion on acute modulations of corticospinal excitability	20
The complexity of Nrf2 in experimental autoimmune myositis‐induced mice	20
Ageing impairs endothelium‐dependent vasodilatation and alters redox signalling in diaphragm arterioles from male and female Fischer‐344 rats	20
Beat‐to‐beat QT interval variability as a tool to detect the underlying cellular mechanisms of arrhythmias	20
The cardiac sodium channel from function to dysfunction	20
Exercise intolerance in pulmonary hypertension: robbing Peter to pay Paul	20
Issue Information	20
TET2 confers a mechanistic link of microRNA‐210 and mtROS in hypoxia‐suppressed spontaneous transient outward currents in uterine arteries of pregnant sheep	20
Respiratory control at high altitude: The chemoreceptor as a paragon of plasticity	20
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Whole‐body metabolic rate is influenced by muscle fibre typology	20
Something's fishy: cardiovascular ATP‐sensitive K+ channels in zebrafish	19
Critical molecular outcomes of time‐restricted feeding during ageing: a look beyond body composition	19
Astrocytes: Orchestrators of brain gas exchange and oxygen homeostasis	19
Past questions, present results, future perspectives: Interacting chemosensitive areas and the hypercapnic ventilatory response	19
Central α2‐adrenergic mechanisms regulate human sympathetic neuronal discharge strategies	19
Towards spatially selective efferent neuromodulation: anatomical and functional organization of cardiac fibres in the porcine cervical vagus nerve	19
An automated respiratory data pipeline for waveform characteristic analysis	19
Particle‐swarm based modelling reveals two distinct classes of CRHPVN neurons	19
Adrenergic restraint of blood flow and high‐altitude acclimatization	19
Characterizing the effects of type I collagen alterations on respiratory function in mouse models with varying severity of osteogenesis imperfecta	19
Intrinsic motoneuron properties in typical human development	19
Muscular strength, endothelial function and cognitive disorders: state of the art	19
Novel regenerative drug, SPG302 promotes functional recovery of diaphragm muscle activity after cervical spinal cord injury	19
Hydrogen peroxide and phosphoinositide metabolites synergistically regulate a cation current to influence neuroendocrine cell bursting	19
Who's on first … Na+, HCO3− or CO32−?	19
Pump up the volume: breathing facilitates cardiac output during exercise by mechanical action	19
The post‐arteriole transitional zone: a specialized capillary region that regulates blood flow within the CNS microvasculature	19
Neurobiology of mitochondrial dynamics in sleep	19
Metabolite‐sensitive cross‐bridge models of human atria reveal the impact of diabetes on muscle mechanoenergetics	19

Mechano‐electrical interactions and heterogeneities in wild‐type and drug‐induced long QT syndrome rabbits	19
Adenine nucleotide translocator and ATP synthase cooperate in mediating the mitochondrial permeability transition	18
Translating physiology of the arterial chemoreflex into novel therapeutic interventions targeting carotid bodies in cardiometabolic disorders	18
Oncomodulin regulates spontaneous calcium signalling and maturation of afferent innervation in cochlear outer hair cells	18
Issue Information	18
Annual Prize Lecture 2024: Endogenous physiological mechanisms as basis for the treatment of obesity and type 2 diabetes	18
Neuroinflammation and the immune system in hypoxic ischaemic brain injury pathophysiology after cardiac arrest	18
A systematic review of computational models for the design of spinal cord stimulation therapies: from neural circuits to patient‐specific simulations	18
Reduced plakoglobin increases the risk of sodium current defects and atrial conduction abnormalities in response to androgenic anabolic steroid abuse	18
Circadian patterns of heart rate variability in fetal sheep after hypoxia‐ischaemia: A biomarker of evolving brain injury	18
The time is now: regular exercise maintains vascular health in ageing women	18
Enter Sandman: An eye opening opinion of cardiovascular disease prevention in cervical spinal cord injury	18
Issue Information	18
Pathogenic TNNT1 variants are associated with aberrant thin filament compliance and myofibre hyper‐contractility	18
Exosomes and the cardiovascular system: role in cardiovascular health and disease	18
Crosstalk between biochemical signalling network architecture and trafficking governs AMPAR dynamics in synaptic plasticity	18
Glyoxalase 1 overexpression improves neurovascular coupling and limits development of mild cognitive impairment in a mouse model of type 1 diabetes	18
Issue Information	18
Issue Information	18
Age‐related diaphragm dysfunction: could diaphragm arteriole dysfunction be to blame?	17
Fasting and the short‐term consumption of a ketogenic diet are sufficient interventions to protect against OLZ‐induced hyperglycaemia in mice	17
Exercise affects fatty acid oxidation and lipid droplets in patients with type 2 diabetes	17
Loss of anoctamin 1 reveals a subtle role for BK channels in lymphatic muscle action potentials	17
Insulin, Nobel laureates and The Journal of Physiology	17
Symptom‐modifying strategy to treat upper respiratory tract infections: a clinical and mechanistic evidence of ColdZyme	17
Untangling age and menopause: vascular mechanisms for cardiovascular disease risk in females	17
Expiratory flow limitation during exercise: why does it ‘suck’ so much?	17
Comparison of excitation–contraction coupling between Drosophila and vertebrate muscle	17
When right ventricular pressure meets volume: The impact of arrival time of reflected waves on right ventricle load in pulmonary arterial hypertension	17
The legacy of A. V. Hill's Nobel Prize winning work on muscle energetics	17
Becoming mindful of mindfulness: a promising approach to reducing sympathetic nervous system overactivity in chronic kidney disease	17
Time course and fibre type‐dependent nature of calcium‐handling protein responses to sprint interval exercise in human skeletal muscle	17
What is fetal growth restriction and how might we know?	17
Rebuttal from Amy Richardson and Gareth Morris	17
Muscle–fat crosstalk: effects of exercise on brown adipose tissue; what do we know?	16
Mitochondrial function in brain and muscle metabolism: the crucial role during early sensorimotor development	16
Blebbistatin reduces calcium buffering in cardiomyocytes: Consequences for cellular electrophysiology	16
Vaping for two: unravelling the mysteries of E‐cigarettes and fetal vascular health	16
Physiological mechanisms of unexplained (functional) gastrointestinal disorders	16
Autonomic modulation with mindfulness‐based stress reduction in chronic kidney disease: a randomized controlled trial	16
Adeno‐associated virus‐based rescue of Myo7a expression restores hair‐cell function and improves hearing thresholds in a USH1B mouse strain	16
Homeostasis and evolution in relation to regeneration and repair	16
Deficiency of PKA‐mediated SNAP‐25b phosphorylation destabilizes exocytotic fusion pores and reduces the interactions of t‐SNAREs	16
Directional sensitivity of C‐low‐threshold mechanoreceptors: insights from in vivo calcium imaging	16
Extracellular vesicles and their microRNA cargo in ischaemic stroke	16
Oxytocin and corticotropin‐releasing hormone exaggerate nucleus tractus solitarii neuronal and synaptic activity following chronic intermittent hypoxia	16
Scale‐invariant changes in corticospinal excitability reflect multiplexed oscillations in the motor output	16
Activation of TRPA1 and TRPM3 triggers Ca 2+ waves in central terminals of sensory neurons and facilitates synaptic activity in the spinal dorsal hor	16
Atypical delayed paired‐pulse depression at an identified synapse	16
‘Mini analysis’ misrepresents changes in synaptic properties due to incomplete event detection	16
Ca2+ signalling in interstitial cells of Cajal contributes to generation and maintenance of tone in mouse and monkey lower oesophageal sphincters	16
Ubiquitin ligase signalling networks shape presynaptic development, function and disease	16
High altitude differentially modulates potassium channel‐evoked vasodilatation in pregnant human myometrial arteries	16
Neural coordination of bilateral hand movements: evidence for an involvement of brainstem motor centres	16
Cross Talk proposal: Human‐derived brain tissue is a better epilepsy model than animal‐based approaches	16
Stepping up to inspire in muscular dystrophy	16
Channelling protons out of the heart	16
Presynaptic quantal size enhancement counteracts post‐tetanic release depression	16
Cardiac programming in the placentally restricted sheep fetus in early gestation	16
Phase‐dependent local brain states determine the impact of image‐guided transcranial magnetic stimulation on motor network electroencephalographic synchronization	16
Pancreatic acinar cell signalling and function exhibit an absolute requirement for activation of Gαq	16
Ageing‐induced weakness of mouse NMJs is associated with reduced active zone density, synaptic event kinetics and presynaptic calcium entry	16
Transient capacitance changes recorded from vestibular type I hair cells are produced by GK,L gating and do not involve neurotransmitter exocytosis	15
Endurance training increases a ubiquitylated form of histone H3 in the skeletal muscle, supporting Notch1 upregulation in an MDM2‐dependent manner	15
Beyond the madness: a balanced approach to standardization, practicality and innovation in exercise physiology threshold assessment	15
Paraventricular nucleus projections to the nucleus tractus solitarii are essential for full expression of hypoxia‐induced peripheral chemoreflex responses	15
Notch1 promotes ordered revascularization through Semaphorin 3g modulation of downstream vascular patterning signalling factors	15
Stem cell approaches for tendon repair: delusion or insight	15
The cardiac pacemakers: A paradigm of robustness in evolutionary biology	15
Now and then: Development of spinal Shox2 neurons	15
Exercise‐induced arterial hypoxaemia in patients with heart failure with preserved ejection fraction	15
Recurrence of ventricular fibrillation in out‐of‐hospital cardiac arrest: Clinical evidence and underlying ionic mechanisms	15
A narrative review of periodic breathing during sleep at high altitude: From acclimatizing lowlanders to adapted highlanders	15
The repair capacity spectrum of human skeletal muscle injury from sports to surgical trauma settings	15
Correction to ‘A single bout of prior resistance exercise attenuates muscle atrophy and declines in myofibrillar protein synthesis during bed‐rest in older men’	15
Chemoreflex function in pulmonary diseases – A review	15
State‐dependent neural representations of muscle synergies in the spinal cord revealed by optogenetic stimulation	15
Can muscle typology explain the inter‐individual variability in resistance training adaptations?	15
Plasma measurements of the dual sugar test reveal carbohydrate immediately alleviates intestinal permeability caused by exertional heat stress	15
The contribution of age and sex hormones to female neuromuscular function across the adult lifespan	14
Cardiac connections: Effects on the heart as a result of autosomal recessive polycystic kidney disease	14
C‐tactile afferents: The mystery of human emotional touch has been hidden hair‐deep	14
ER‐Ca2+ stores and the regulation of store‐operated Ca2+ entry in neurons	14
BK channels at dendritic spines: A mechanism for coupling morphology, plasticity and information storage?	14
Interstitial cells of Cajal – pacemakers of the gastrointestinal tract	14
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Modulation of neurometabolites in sensory processing brain areas during motor learning	14
Targeting ALDH2 to promote skeletal muscle health: A novel strategy against mitochondrial dysfunction	14
Heartfelt intervention: A role for PVN oxytocin neurons in the prediabetic heart	14
A very brief note on why bacterial evolution has physiology	14
Issue Information	14
Redefining human heat limits: integrating molecular and evolutionary physiology	14
Sex‐specific effects of betamethasone on glucocorticoid and apoptotic signalling pathways in the sheep placenta	14
Acute intermittent hypoxia increases maximal motor unit discharge rates in people with chronic incomplete spinal cord injury	14
Mutation protocols share with sexual reproduction the physiological role of producing genetic variation within ‘constraints that deconstrain’	14