Journal of Physiology-London

Article	Citations
Revisiting the Warburg effect: historical dogma versus current understanding	449
The anaerobic threshold: 50+ years of controversy	183
Lactate in contemporary biology: a phoenix risen	107
Hepatic stellate cells in physiology and pathology	97
Neuromuscular junction instability and altered intracellular calcium handling as early determinants of force loss during unloading in humans	68
COVID‐19 is getting on our nerves: sympathetic neural activity and haemodynamics in young adults recovering from SARS‐CoV‐2	64
Silent hypoxaemia in COVID‐19 patients	63
Low‐volume high‐intensity interval training for cardiometabolic health	58
The envelope protein of SARS‐CoV‐2 increases intra‐Golgi pH and forms a cation channel that is regulated by pH	53
Common synaptic input, synergies and size principle: Control of spinal motor neurons for movement generation	49
Piezo1 channels mediate trabecular meshwork mechanotransduction and promote aqueous fluid outflow	48
The noradrenergic agent reboxetine plus the antimuscarinic hyoscine butylbromide reduces sleep apnoea severity: a double‐blind, placebo‐controlled, randomised crossover trial	48
Passive stiffness of fibrotic skeletal muscle in mdx mice relates to collagen architecture	48
Ca2+‐permeable AMPA receptors and their auxiliary subunits in synaptic plasticity and disease	47
Synergic control of a single muscle: The example of flexor digitorum superficialis	46
Estimates of persistent inward currents are reduced in upper limb motor units of older adults	46
Physiological and molecular sex differences in human skeletal muscle in response to exercise training	45
Genetic and epigenetic regulation of skeletal muscle ribosome biogenesis with exercise	45
Deficit in knee extension strength following anterior cruciate ligament reconstruction is explained by a reduced neural drive to the vasti muscles	42
Pregnancy‐induced changes in β‐cell function: what are the key players?	42
Positive allosteric modulation of NMDA receptors: mechanisms, physiological impact and therapeutic potential	41
Time restricted eating for the prevention of type 2 diabetes	41
The mechanisms of skeletal muscle atrophy in response to transient knockdown of the vitamin D receptor in vivo	39
On the role of skeletal muscle acidosis and inorganic phosphates as determinants of central and peripheral fatigue: A 31P‐MRS study	36
Autonomic control of cerebral blood flow: fundamental comparisons between peripheral and cerebrovascular circulations in humans	35

1,25(OH)2 vitamin D3 stimulates active phosphate transport but not paracellular phosphate absorption in mouse intestine	35
Nicotinamide riboside supplementation does not alter whole‐body or skeletal muscle metabolic responses to a single bout of endurance exercise	35
Divergence of neuroimmune circuits activated by afferent and efferent vagal nerve stimulation in the regulation of inflammation	34
Encoding sound in the cochlea: from receptor potential to afferent discharge	34
Mitochondrial dysfunction in placental trophoblast cells experiencing gestational diabetes mellitus	34
The influence of aerobic exercise on mitochondrial quality control in skeletal muscle	32
Loss of Baiap2l2 destabilizes the transducing stereocilia of cochlear hair cells and leads to deafness	32
Transcriptomic, proteomic and phosphoproteomic underpinnings of daily exercise performance and zeitgeber activity of training in mouse muscle	32
Extracellular miRNAs as mediators of obesity‐associated disease	32
Single muscle fibre contractile function with ageing	31
Localization of Na+ channel clusters in narrowed perinexi of gap junctions enhances cardiac impulse transmission via ephaptic coupling: a model study	30
Effects of reciprocal inhibition and whole‐body relaxation on persistent inward currents estimated by two different methods	29
Photoreceptor physiology and evolution: cellular and molecular basis of rod and cone phototransduction	29
Biochemical and structural basis of the passive mechanical properties of whole skeletal muscle	29
Effects of short‐term unloading and active recovery on human motor unit properties, neuromuscular junction transmission and transcriptomic profile	28
Exosome engineering for efficient and targeted drug delivery: Current status and future perspective	28
Physiology of physical inactivity, sedentary behaviours and non‐exercise activity: insights from the space bedrest model	28
Near‐infrared spectroscopy estimation of combined skeletal muscle oxidative capacity and O2 diffusion capacity in humans	28
Analysis of extracellular spike waveforms and associated receptive fields of neurons in cat primary visual cortex	28
Time‐dependent changes in autophagy, mitophagy and lysosomes in skeletal muscle during denervation‐induced disuse	28
The correspondence between EMG and EEG measures of changes in cortical excitability following transcranial magnetic stimulation	27
Regulation of plasma volume in male lowlanders during 4 days of exposure to hypobaric hypoxia equivalent to 3500 m altitude	27
Advancing respiratory–cardiovascular physiology with the working heart–brainstem preparation over 25 years	27
The beta2‐adrenergic receptor – a re‐emerging target to combat obesity and induce leanness?	27
The effects of maternal position, in late gestation pregnancy, on placental blood flow and oxygenation: an MRI study	26
Hypertrophied human adipocyte spheroids as in vitro model of weight gain and adipose tissue dysfunction	26
Physiological aspects of cardiopulmonary dysanapsis on exercise in adults born preterm	26
Biophysical and morphological changes in inner hair cells and their efferent innervation in the ageing mouse cochlea	26
Acid–base balance and cerebrovascular regulation	26
Biased auditory nerve central synaptopathy is associated with age‐related hearing loss	26
Dysbiosis of the gut microbiome impairs mouse skeletal muscle adaptation to exercise	26
Interpreting ‘anti‐inflammatory’ cytokine responses to exercise: focus on interleukin‐10	25
Vascular calcium signalling and ageing	25
Abnormal skeletal muscle blood flow, contractile mechanics and fibre morphology in a rat model of obese‐HFpEF	25
Towards a mechanistic approach for the development of non‐invasive brain‐computer interfaces for motor rehabilitation	25
Nutrient timing and metabolic regulation	25
The suitability of high throughput automated patch clamp for physiological applications	25
Facilitation–inhibition control of motor neuronal persistent inward currents in young and older adults	25
Regulation of muscle and mitochondrial health by the mitochondrial fission protein Drp1 in aged mice	25
Time‐restricted feeding combined with aerobic exercise training can prevent weight gain and improve metabolic disorders in mice fed a high‐fat diet	25
Ageing and exercise‐induced motor unit remodelling	25
Quantification of cardiac and respiratory modulation of axonal activity in the human vagus nerve	24
Long‐duration spaceflight alters estimated intracranial pressure and cerebral blood velocity	24
NAD+ and NAFLD – caution, causality and careful optimism	24
Motor potentials evoked by transcranial magnetic stimulation: interpreting a simple measure of a complex system	24
Nitric oxide contributes to cerebrovascular shear‐mediated dilatation but not steady‐state cerebrovascular reactivity to carbon dioxide	24
How does oxygen diffuse from capillaries to tissue mitochondria? Barriers and pathways	24
Zona incerta neurons projecting to the ventral tegmental area promote action initiation towards feeding	24
Vesicle‐released glutamate is necessary to maintain muscle spindle afferent excitability but not dynamic sensitivity in adult mice	23
Optical measurement of physiological sodium currents in the axon initial segment	23

Peripheral impairments of oxidative metabolism after a 10‐day bed rest are upstream of mitochondrial respiration	23
Fetal growth, birth size and energetic cost of gestation in southern right whales	23
Inhaled nitric oxide improves ventilatory efficiency and exercise capacity in patients with mild COPD: A randomized‐control cross‐over trial	23
Arterial carbon dioxide and bicarbonate rather than pH regulate cerebral blood flow in the setting of acute experimental metabolic alkalosis	23
Glial amplification of synaptic signals	22
NMDA receptors in axons: there's no coincidence	22
Correlation networks of spinal motor neurons that innervate lower limb muscles during a multi‐joint isometric task	22
Intermuscular coherence analysis in older adults reveals that gait‐related arm swing drives lower limb muscles via subcortical and cortical pathways	22
Exposure to high fructose corn syrup during adolescence in the mouse alters hepatic metabolism and the microbiome in a sex‐specific manner	22
Gut peptide regulation of food intake – evidence for the modulation of hedonic feeding	21
Obesity and gestational diabetes independently and collectively induce specific effects on placental structure, inflammation and endocrine function in a cohort of South African women	21
Breathing in Duchenne muscular dystrophy: translation to therapy	21
PKCε stimulation of TRPV1 orchestrates carotid body responses to asthmakines	21
Mechanisms underlying the health benefits of intermittent hypoxia conditioning	21
Blockade of 5‐HT2 receptors suppresses motor unit firing and estimates of persistent inward currents during voluntary muscle contraction in humans	21
Location, location, location: the organization and roles of potassium channels in mammalian motoneurons	21
Divergent immunometabolic changes in adipose tissue and skeletal muscle with ageing in healthy humans	21
The role of mitochondria in metabolic disease: a special emphasis on heart dysfunction	21
Short‐term ketone monoester supplementation improves cerebral blood flow and cognition in obesity: A randomized cross‐over trial	21
Motor unit dysregulation following 15 days of unilateral lower limb immobilisation	20
Connexin 46 and connexin 50 gap junction channel properties are shaped by structural and dynamic features of their N‐terminal domains	20
GluN3A NMDA receptor subunits: more enigmatic than ever?	20
Intrinsic and synaptic mechanisms controlling the expiratory activity of excitatory lateral parafacial neurones of rats	20
What gets on the nerves of cardiac patients? Pathophysiological changes in cardiac innervation	20
Preserved skeletal muscle oxidative capacity in older adults despite decreased cardiorespiratory fitness with ageing	20
Maternal obesity causes fetal cardiac hypertrophy and alters adult offspring myocardial metabolism in mice	20
Vagus nerve stimulation activates nucleus of solitary tract neurons via supramedullary pathways	20
Adipocyte function and the development of cardiometabolic disease	20
Mitochondrial carbonic anhydrase VA and VB: properties and roles in health and disease	19
Remote ischaemic preconditioning – translating cardiovascular benefits to humans	19
Maternal but not fetoplacental health can be improved by metformin in a murine diet‐induced model of maternal obesity and glucose intolerance	19
Influence of the mode of heating on cerebral blood flow, non‐invasive intracranial pressure and thermal tolerance in humans	19
Abnormal cerebellar function and tremor in a mouse model for non‐manifesting partially penetrant dystonia type 6	19
Nitrate‐rich beetroot juice ingestion reduces skeletal muscle O2 uptake and blood flow during exercise in sedentary men	19
The 70‐year search for the voltage‐sensing mechanism of ion channels	19
Junctophilin‐4 facilitates inflammatory signalling at plasma membrane‐endoplasmic reticulum junctions in sensory neurons	19
Increasing SERCA function promotes initiation of calcium sparks and breakup of calcium waves	19
Phenotyping heart failure using model‐based analysis and physiology‐informed machine learning	19
Exercise training remodels subcutaneous adipose tissue in adults with obesity even without weight loss	19
Inflammatory gene expression during acute high‐altitude exposure	19
Optogenetic approaches to therapy for inherited retinal degenerations	19
Role of pattern recognition receptors and the microbiota in neurological disorders	19
Biological sex, not reproductive cycle, influences peripheral blood immune cell prevalence in mice	19
An MRI approach to assess placental function in healthy humans and sheep	19
Sex differences in the sympathetic neurocirculatory responses to chemoreflex activation	19
Publications, replication and statistics in physiology plus two neglected curves	19
Low energy availability reduces myofibrillar and sarcoplasmic muscle protein synthesis in trained females	18
The ketogenic diet prevents steatosis and insulin resistance by reducing lipogenesis, diacylglycerol accumulation and protein kinase C activity in male rat liver	18
Rapid volume pulsation of the extracellular space coincides with epileptiform activity in mice and depends on the NBCe1 transporter	18
Resilience of neural networks for locomotion	18
Functional development and regeneration of hair cells in the zebrafish lateral line	18
Preserved stem cell content and innervation profile of elderly human skeletal muscle with lifelong recreational exercise	18
Sodium channels and the ionic microenvironment of breast tumours	18
Physiological roles of heteromerization: focus on the two‐pore domain potassium channels	18
Oxidant‐resistant LRRC8A/C anion channels support superoxide production by NADPH oxidase 1	18
Structural basis for positive allosteric modulation of AMPA and kainate receptors	18
Influence of iron manipulation on hypoxic pulmonary vasoconstriction and pulmonary reactivity during ascent and acclimatization to 5050 m	18
Circulating exosome‐like vesicle and skeletal muscle microRNAs are altered with age and resistance training	18
The capillary fascicle in skeletal muscle: Structural and functional physiology of RBC distribution in capillary networks	18
Endocytic adaptation to functional demand by the kidney proximal tubule	18
Glucocorticoids regulate mitochondrial fatty acid oxidation in fetal cardiomyocytes	18
The fourth dimension: physiological resilience as an independent determinant of endurance exercise performance	18
AMP‐activated protein kinase activation in skeletal muscle modulates exercise‐induced uncoupled protein 1 expression in brown adipocyte in mouse model	17
Critical considerations of the contribution of the corticomotoneuronal pathway to central fatigue	17
Late gestation fetal hyperglucagonaemia impairs placental function and results in diminished fetal protein accretion and decreased fetal growth	17
A molecular signature defining exercise adaptation with ageing and in vivo partial reprogramming in skeletal muscle	17
Leptin mediates the regulation of muscle mass and strength by adipose tissue	17
A sodium background conductance controls the spiking pattern of mouse adrenal chromaffin cells in situ	17
Oxygenation pattern and compensatory responses to hypoxia and hypercapnia following bilateral carotid body resection in humans	17
Divergent splanchnic sympathetic efferent nerve pathways regulate interleukin‐10 and tumour necrosis factor‐α responses to endotoxaemia	17
Voluntary activation of muscle in humans: does serotonergic neuromodulation matter?	17
S100β‐mediated astroglial control of firing and input processing in layer 5 pyramidal neurons of the mouse visual cortex	17
Sexually dimorphic response of colorectal motility to noxious stimuli in the colorectum in rats	17
Carbohydrate improves exercise capacity but does not affect subcellular lipid droplet morphology, AMPK and p53 signalling in human skeletal muscle	17
Excessive endoplasmic reticulum stress drives aberrant mouse trophoblast differentiation and placental development leading to pregnancy loss	17
Rhythmic neuronal activities of the rat nucleus of the solitary tract are impaired by high‐fat diet – implications for daily control of satiety	17
Exon 2‐mediated deletion of Trem2 does not worsen metabolic function in diet‐induced obese mice	17
Exertional dyspnoea in patients with mild‐to‐severe chronic obstructive pulmonary disease: neuromechanical mechanisms	17
Na+ is shifted from the extracellular to the intracellular compartment and is not inactivated by glycosaminoglycans during high salt conditions in rats	17
Regulation of excitation‐contraction coupling at the Drosophila neuromuscular junction	17

Temporal control of muscle synergies is linked with alpha‐band neural drive	16
Short‐term exercise‐induced protection of cardiovascular function and health: why and how fast does the heart benefit from exercise?	16
A change of heart: understanding the mechanisms regulating cardiac proliferation and metabolism before and after birth	16
The molecular mechanism of CFTR‐ and secretin‐dependent renal bicarbonate excretion	16
Naked mole‐rat brain mitochondria tolerate in vitro ischaemia	16
Mechanisms of Hebbian‐like plasticity in the ventral premotor – primary motor network	16
Selective activation of BK channels in small‐headed dendritic spines suppresses excitatory postsynaptic potentials	16
Regulation of metabolic health by dietary histidine in mice	16
Regulation of cardiovascular health and disease by visceral adipose tissue‐derived metabolic hormones	16
Fasting for 20 h does not affect exercise‐induced increases in circulating BDNF in humans	16
Long‐term potentiation in neurogliaform interneurons modulates excitation–inhibition balance in the temporoammonic pathway	16
Profoundly lower muscle mass and rate of contractile protein synthesis in boys with Duchenne muscular dystrophy	16
TRPV1 in arteries enables a rapid myogenic tone	15
The LRRC family of BK channel regulatory subunits: potential roles in health and disease	15
Nerve growth factor transfer from cardiomyocytes to innervating sympathetic neurons activates TrkA receptors at the neuro‐cardiac junction	15
High‐definition transcranial direct current stimulation modulates performance and alpha/beta parieto‐frontal connectivity serving fluid intelligence	15
Altered muscle mitochondrial, inflammatory and trophic markers, and reduced exercise training adaptations in type 1 diabetes	15
Intrauterine growth restriction elevates circulating acylcarnitines and suppresses fatty acid metabolism genes in the fetal sheep heart	15
Fast and sensitive GCaMP calcium indicators for neuronal imaging	15
Nitric oxide synthase inhibition in healthy adults reduces regional and total cerebral macrovascular blood flow and microvascular perfusion	15
Bile acid‐ and ethanol‐mediated activation of Orai1 damages pancreatic ductal secretion in acute pancreatitis	15
Differential contributions of cardiac, coronary and pulmonary artery vagal mechanoreceptors to reflex control of the circulation	15
The impact of acute and chronic stress on gastrointestinal physiology and function: a microbiota–gut–brain axis perspective	15
Ca2+ signalling in interstitial cells of Cajal contributes to generation and maintenance of tone in mouse and monkey lower oesophageal sphincters	15
Corticoreticulospinal tract neurophysiology in an arm and hand muscle in healthy and stroke subjects	15
Neonatal antibiotics have long term sex‐dependent effects on the enteric nervous system	15
The effect of time‐of‐day and circadian phase on vulnerability to seizure‐induced death in two mouse models	15
Sex differences in diaphragmatic fatigue: Effects of hypoxia during inspiratory loading	15
The influence of maturation on exercise‐induced cardiac remodelling and haematological adaptation	15
Exercise‐induced histone H3 trimethylation at lysine 27 facilitates the adaptation of skeletal muscle to exercise in mice	15
In vivoelectrophysiological mechanisms underlying cervical epidural stimulation in adult rats	15
Acute intermittent hypercapnic‐hypoxia elicits central neural respiratory motor plasticity in humans	14
Correlating genotype with phenotype using CFTR‐mediated whole‐cell Cl− currents in human nasal epithelial cells	14
Adaptive exhaustion during prolonged intermittent hypoxia causes dysregulated skeletal muscle protein homeostasis	14
The myonuclear domain in adult skeletal muscle fibres: past, present and future	14
A deep analysis of the proteomic and phosphoproteomic alterations that occur in skeletal muscle after the onset of immobilization	14
Global REACH 2018: the adaptive phenotype to life with chronic mountain sickness and polycythaemia	14
Modes of action of lysophospholipids as endogenous activators of the TRPV4 ion channel	14
Inhibitory interneurons show early dysfunction in a SOD1 mouse model of amyotrophic lateral sclerosis	14
Initiation of 3,3‐dimethyl‐1‐butanol at midlife prevents endothelial dysfunction and attenuates in vivo aortic stiffening with ageing in mice	14
JAK/STAT inhibition augments soleus muscle function in a rat model of critical illness myopathy via regulation of complement C3/3R	14
Kappa opioids inhibit the GABA/glycine terminals of rostral ventromedial medulla projections in the superficial dorsal horn of the spinal cord	14
Properties and modulation of excitatory inputs to the locus coeruleus	14
Melanin‐concentrating hormone‐producing neurons in the hypothalamus regulate brown adipose tissue and thus contribute to energy expenditure	14
Mechanisms of spontaneous Ca2+ release‐mediated arrhythmia in a novel 3D human atrial myocyte model: I. Transverse‐axial tubule variation	14
Modelling normal and nephrotic axial uptake of albumin and other filtered proteins along the proximal tubule	14
The association between pain‐induced autonomic reactivity and descending pain control is mediated by the periaqueductal grey	14
Post‐exercise intramuscular O2 supply is tightly coupled with a higher proximal‐to‐distal ATP synthesis rate in human tibialis anterior	14
Brain blood and cerebrospinal fluid flow dynamics during rhythmic handgrip exercise in young healthy men and women	14
Subcellular diversity of Nav1.5 in cardiomyocytes: distinct functions, mechanisms and targets	14
How the Hodgkin cycle became the principle of biological relativity	14
The ventromedial prefrontal cortex and emotion regulation: lost in translation?	14
An obesogenic diet impairs uncoupled substrate oxidation and promotes whitening of the brown adipose tissue in rats	14
Predicting the protein composition of human urine in normal and pathological states: Quantitative description based on Dent1 disease (CLCN5 mutation)	14
β‐Catenin is required for optimal exercise‐ and contraction‐stimulated skeletal muscle glucose uptake	14
Daily changes in neuronal activities of the dorsal motor nucleus of the vagus under standard and high‐fat diet	14
Prolyl‐4‐hydroxylases 2 and 3 control erythropoietin production in renin‐expressing cells of mouse kidneys	13
A change of heart: Mechanisms of cardiac adaptation to acute and chronic hypoxia	13
Distinct patterns of spasticity and corticospinal connectivity following complete spinal cord injury	13
MET currents and otoacoustic emissions from mice with a detached tectorial membrane indicate the extracellular matrix regulates Ca2+ near stereocilia	13
Insulin potentiates the response to capsaicin in dorsal root ganglion neurons in vitro and muscle afferents ex vivo in normal healthy rodents	13
Physiological control of fetal heart rate variability during labour: implications and controversies	13
Late sodium current: incomplete inactivation triggers seizures, myotonias, arrhythmias, and pain syndromes	13
The role of intracellular calcium‐store‐mediated calcium signals in in vivo sensor and effector functions of microglia	13
Formation and computational implications of assemblies in neural circuits	13
T cells mediate cell non‐autonomous arterial ageing in mice	13
Exosomes and the cardiovascular system: role in cardiovascular health and disease	13
Phase‐ and state‐dependent modulation of breathing pattern by preBötzinger complex somatostatin expressing neurons	13
Indomethacin markedly blunts cerebral perfusion and reactivity, with little cognitive consequence in healthy young and older adults	13
Changes in neural drive to calf muscles during steady submaximal contractions after repeated static stretches	13
Olivocochlear projections contribute to superior intensity coding in cochlear nucleus small cells	13
Activation mechanisms and structural dynamics of STIM proteins	13
Fibre type‐ and localisation‐specific muscle glycogen utilisation during repeated high‐intensity intermittent exercise	13
Zeitgebers of skeletal muscle and implications for metabolic health	13
Cortical dynamics of movement‐evoked pain in chronic low back pain	13
Divergent effects of initial ventilation with delayed cord clamping on systemic and pulmonary arterial flows in the birth transition of preterm lambs	12
Increased sympathetic and haemodynamic responses to exercise and muscle metaboreflex activation in post‐menopausal women with rheumatoid arthritis	12
Loss of peripheral vestibular input alters the statistics of head movement experienced during natural self‐motion	12
Immobilisation induces sizeable and sustained reductions in forearm glucose uptake in just 24 h but does not change lipid uptake in healthy men	12
A task‐relevant experimental pain model to target motor adaptation	12
Single muscle fibre contractile characteristics with lifelong endurance exercise	12
Adapting to a new environment: postnatal maturation of the human cardiomyocyte	12
KLB dysregulation mediates disrupted muscle development in intrauterine growth restriction	12
Temporal dynamics of the cerebello‐cortical convergence in ventro‐lateral motor thalamus	12
Carotid body hypersensitivity in intermittent hypoxia and obtructive sleep apnoea	12
Ryanodine receptor activity and store‐operated Ca2+ entry: Critical regulators of Ca2+ content and function in skeletal muscle	12
Axonal GABAA stabilizes excitability in unmyelinated sensory axons secondary to NKCC1 activity	12
Identification of a helix–turn–helix motif for high temperature dependence of vanilloid receptor TRPV2	12
Oral and intravenous glucose administration elicit opposing microvascular blood flow responses in skeletal muscle of healthy people: role of incretins	12
Synergistic interaction of nerve growth factor and glial cell‐line derived neurotrophic factor in muscular mechanical hyperalgesia in rats	12
The HVCN1 voltage‐gated proton channel contributes to pH regulation in canine ventricular myocytes	12
Corticothalamic projections deliver enhanced responses to medial geniculate body as a function of the temporal reliability of the stimulus	12
Inter‐spike mitochondrial Ca2+ release enhances high frequency synaptic transmission	12
Cross Talk proposal: Myonuclei are lost with ageing and atrophy	12
Increased mitochondrial surface area and cristae density in the skeletal muscle of strength athletes	12