Journal of Physiology-London

Article	Citations
Regulation of glycolysis by the hypoxia‐inducible factor (HIF): implications for cellular physiology	366
Revisiting the Warburg effect: historical dogma versus current understanding	344
The ARRIVE guidelines 2.0: updated guidelines for reporting animal research	173
The anaerobic threshold: 50+ years of controversy	154
Mitochondrial lactate metabolism: history and implications for exercise and disease	96
HIITing the brain with exercise: mechanisms, consequences and practical recommendations	91
Infiltration of intramuscular adipose tissue impairs skeletal muscle contraction	90
Lactate in contemporary biology: a phoenix risen	83
Molecular and tissue mechanisms of catecholaminergic polymorphic ventricular tachycardia	78
Ketogenic low‐CHO, high‐fat diet: the future of elite endurance sport?	68
Intra‐gastrointestinal amyloid‐β1–42 oligomers perturb enteric function and induce Alzheimer's disease pathology	67
Effects of e‐cigarettes and vaping devices on cardiac and pulmonary physiology	66
COVID‐19 is getting on our nerves: sympathetic neural activity and haemodynamics in young adults recovering from SARS‐CoV‐2	59
Silent hypoxaemia in COVID‐19 patients	58
Drp1 knockdown induces severe muscle atrophy and remodelling, mitochondrial dysfunction, autophagy impairment and denervation	58
Adaptation to a low carbohydrate high fat diet is rapid but impairs endurance exercise metabolism and performance despite enhanced glycogen availability	55
In vivo recordings from the human vagus nerve using ultrasound‐guided microneurography	54
Neuromuscular junction instability and altered intracellular calcium handling as early determinants of force loss during unloading in humans	53
Hepatic stellate cells in physiology and pathology	53
Inter‐hemispheric inhibition sculpts the output of neural circuits by co‐opting the two cerebral hemispheres	52
Nitric oxide is fundamental to neurovascular coupling in humans	51
The envelope protein of SARS‐CoV‐2 increases intra‐Golgi pH and forms a cation channel that is regulated by pH	50
Low‐volume high‐intensity interval training for cardiometabolic health	49
Functional architecture of the motor homunculus detected by electrostimulation	47
Sex differences in fatigability following exercise normalised to the power–duration relationship	46

The noradrenergic agent reboxetine plus the antimuscarinic hyoscine butylbromide reduces sleep apnoea severity: a double‐blind, placebo‐controlled, randomised crossover trial	46
Lifelong voluntary aerobic exercise prevents age‐ and Western diet‐ induced vascular dysfunction, mitochondrial oxidative stress and inflammation in mice	42
Mechanisms underlying selective coupling of endothelial Ca2+ signals with eNOS vs. IK/SK channels in systemic and pulmonary arteries	42
Time‐of‐day dependent effects of contractile activity on the phase of the skeletal muscle clock	42
Genetic and epigenetic regulation of skeletal muscle ribosome biogenesis with exercise	42
Zolpidem increases sleep efficiency and the respiratory arousal threshold without changing sleep apnoea severity and pharyngeal muscle activity	42
Normal human and sheep fetal vessel oxygen saturations by T2 magnetic resonance imaging	41
Synergic control of a single muscle: The example of flexor digitorum superficialis	41
Divergent response of low‐ versus high‐threshold motor units to experimental muscle pain	40
Fitness and strength responses to distinct exercise modes in twins: Studies of Twin Responses to Understand Exercise as a THerapy (STRUETH) study	40
Architecture and function of NMDA receptors: an evolutionary perspective	39
Passive stiffness of fibrotic skeletal muscle in mdx mice relates to collagen architecture	39
Estimates of persistent inward currents are reduced in upper limb motor units of older adults	38
Ca2+‐permeable AMPA receptors and their auxiliary subunits in synaptic plasticity and disease	38
Piezo1 channels mediate trabecular meshwork mechanotransduction and promote aqueous fluid outflow	38
TRPV1 expressed throughout the arterial circulation regulates vasoconstriction and blood pressure	38
Training with blood flow restriction increases femoral artery diameter and thigh oxygen delivery during knee‐extensor exercise in recreationally trained men	37
Internal carotid and brachial artery shear‐dependent vasodilator function in young healthy humans	36
Coupling structure with function in acid‐sensing ion channels: challenges in pursuit of proton sensors	36
Distinct features of calcium handling and β‐adrenergic sensitivity in heart failure with preserved versus reduced ejection fraction	36
The mechanisms of skeletal muscle atrophy in response to transient knockdown of the vitamin D receptor in vivo	35
Deficit in knee extension strength following anterior cruciate ligament reconstruction is explained by a reduced neural drive to the vasti muscles	35
Anodal and cathodal tDCS modulate neural activity and selectively affect GABA and glutamate syntheses in the visual cortex of cats	35
Dysregulation of external globus pallidus‐subthalamic nucleus network dynamics in parkinsonian mice during cortical slow‐wave activity and activation	34
August Krogh's theory of muscle microvascular control and oxygen delivery: a paradigm shift based on new data	34
E‐cigarettes and respiratory health: the latest evidence	34
Kir6.1‐dependent KATP channels in lymphatic smooth muscle and vessel dysfunction in mice with Kir6.1 gain‐of‐function	34
Pregnancy‐induced changes in β‐cell function: what are the key players?	34
Influence of sex on the age‐related adaptations of neuromuscular function and motor unit properties in elite masters athletes	34
Functional, proteomic and bioinformatic analyses of Nrf2‐ and Keap1‐ null skeletal muscle	34
From bedside‐to‐bench: What disease‐associated variants are teaching us about the NMDA receptor	33
Divergence of neuroimmune circuits activated by afferent and efferent vagal nerve stimulation in the regulation of inflammation	33
Physiological and molecular sex differences in human skeletal muscle in response to exercise training	33
Nicotinamide riboside supplementation does not alter whole‐body or skeletal muscle metabolic responses to a single bout of endurance exercise	32
New insights into resting and exertional right ventricular performance in the healthy heart through real‐time pressure‐volume analysis	32
In vitro ketone‐supported mitochondrial respiration is minimal when other substrates are readily available in cardiac and skeletal muscle	32
Volumetric mapping of the functional neuroanatomy of the respiratory network in the perfused brainstem preparation of rats	31
Respiratory cerebrospinal fluid flow is driven by the thoracic and lumbar spinal pressures	31
Positive allosteric modulation of NMDA receptors: mechanisms, physiological impact and therapeutic potential	30
Encoding sound in the cochlea: from receptor potential to afferent discharge	30
Mitochondrial dysfunction in placental trophoblast cells experiencing gestational diabetes mellitus	30
1,25(OH)2 vitamin D3 stimulates active phosphate transport but not paracellular phosphate absorption in mouse intestine	30
Current research: effect of time restricted eating on weight and cardiometabolic health	30
Enhanced serotonin availability amplifies fatigue perception and modulates the TMS‐induced silent period during sustained low‐intensity elbow flexions	30
The influence of aerobic exercise on mitochondrial quality control in skeletal muscle	29
Common synaptic input, synergies and size principle: Control of spinal motor neurons for movement generation	29
Age‐related changes in the biophysical and morphological characteristics of mouse cochlear outer hair cells	29
The need for specificity in quantifying neurocirculatory vs. respiratory effects of eucapnic hypoxia and transient hyperoxia	29
Loss of Baiap2l2 destabilizes the transducing stereocilia of cochlear hair cells and leads to deafness	28
Chronic cold exposure induces mitochondrial plasticity in deer mice native to high altitudes	28

Modulation of Kv3.1/Kv3.2 promotes gamma oscillations by rescuing Aβ‐induced desynchronization of fast‐spiking interneuron firing in an AD mouse model in vitro	28
Step time asymmetry but not step length asymmetry is adapted to optimize energy cost of split‐belt treadmill walking	28
Peripheral chemoreflex contribution to ventilatory long‐term facilitation induced by acute intermittent hypercapnic hypoxia in males and females	27
Unchanged cerebrovascular CO2 reactivity and hypercapnic ventilatory response during strict head‐down tilt bed rest in a mild hypercapnic environment	27
Heterogeneity in subcellular muscle glycogen utilisation during exercise impacts endurance capacity in men	27
Peripheral chemoreflex control of fetal heart rate decelerations overwhelms the baroreflex during brief umbilical cord occlusions in fetal sheep	27
The exercise pressor reflex and chemoreflex interaction: cardiovascular implications for the exercising human	27
Extracellular miRNAs as mediators of obesity‐associated disease	27
Autonomic control of cerebral blood flow: fundamental comparisons between peripheral and cerebrovascular circulations in humans	26
Effects of reciprocal inhibition and whole‐body relaxation on persistent inward currents estimated by two different methods	26
Time restricted eating for the prevention of type 2 diabetes	26
E‐cigarettes, nicotine, the lung and the brain: multi‐level cascading pathophysiology	25
Evidence for improved systemic and local vascular function after long‐term passive static stretching training of the musculoskeletal system	25
Spike‐wave discharges in absence epilepsy: segregation of electrographic components reveals distinct pathways of seizure activity	25
Transcriptomic, proteomic and phosphoproteomic underpinnings of daily exercise performance and zeitgeber activity of training in mouse muscle	25
Contraction influences Per2 gene expression in skeletal muscle through a calcium‐dependent pathway	25
Localization of Na+ channel clusters in narrowed perinexi of gap junctions enhances cardiac impulse transmission via ephaptic coupling: a model study	25
The correspondence between EMG and EEG measures of changes in cortical excitability following transcranial magnetic stimulation	25
Direct evidence for decreased presynaptic inhibition evoked by PBSt group I muscle afferents after chronic SCI and recovery with step‐training in rats	25
Photoreceptor physiology and evolution: cellular and molecular basis of rod and cone phototransduction	25
Modulation of information processing by AMPA receptor auxiliary subunits	24
Regulation of plasma volume in male lowlanders during 4 days of exposure to hypobaric hypoxia equivalent to 3500 m altitude	24
Optical measurement of physiological sodium currents in the axon initial segment	24
Locomotor muscle group III/IV afferents constrain stroke volume and contribute to exercise intolerance in human heart failure	24
Acute activation of bronchopulmonary vagal nociceptors by type I interferons	24
Blood viscosity and its determinants in the highest city in the world	24
Analysis of extracellular spike waveforms and associated receptive fields of neurons in cat primary visual cortex	24
Spinal motoneurones are intrinsically more responsive in the adult G93A SOD1 mouse model of amyotrophic lateral sclerosis	24
Advancing respiratory–cardiovascular physiology with the working heart–brainstem preparation over 25 years	23
Kv3.1 and Kv3.3 subunits differentially contribute to Kv3 channels and action potential repolarization in principal neurons of the auditory brainstem	23
Inhibitory interneurons regulate phasic activity of noradrenergic neurons in the mouse locus coeruleus and functional implications	23
Hodgkin–Huxley–Katz Prize Lecture: Genetic and pharmacological control of glutamate receptor channel through a highly conserved gating motif	23
Vitamin D is an endogenous partial agonist of the transient receptor potential vanilloid 1 channel	23
Exertional heat stroke leads to concurrent long‐term epigenetic memory, immunosuppression and altered heat shock response in female mice	23
Biased auditory nerve central synaptopathy is associated with age‐related hearing loss	23
Protease‐dependent excitation of nodose ganglion neurons by commensal gut bacteria	23
Biochemical and structural basis of the passive mechanical properties of whole skeletal muscle	23
Inhibitory control of active expiration by the Bötzinger complex in rats	23
Myosin dynamics during relaxation in mouse soleus muscle and modulation by 2′‐deoxy‐ATP	23
CaMKII activity contributes to homeometric autoregulation of the heart: A novel mechanism for the Anrep effect	23
Vascular calcium signalling and ageing	22
Dysbiosis of the gut microbiome impairs mouse skeletal muscle adaptation to exercise	22
Vesicle‐released glutamate is necessary to maintain muscle spindle afferent excitability but not dynamic sensitivity in adult mice	22
The beta2‐adrenergic receptor – a re‐emerging target to combat obesity and induce leanness?	22
On the role of skeletal muscle acidosis and inorganic phosphates as determinants of central and peripheral fatigue: A 31P‐MRS study	22
Towards a mechanistic approach for the development of non‐invasive brain‐computer interfaces for motor rehabilitation	22
Hypertrophied human adipocyte spheroids as in vitro model of weight gain and adipose tissue dysfunction	22
Local sleep spindles in the human thalamus	22
Skeletal muscle AMPK is not activated during 2 h of moderate intensity exercise at ∼65% in endurance trained men	22
Long‐duration spaceflight alters estimated intracranial pressure and cerebral blood velocity	22
Biophysical and morphological changes in inner hair cells and their efferent innervation in the ageing mouse cochlea	22
Physiology of physical inactivity, sedentary behaviours and non‐exercise activity: insights from the space bedrest model	22
Pathophysiological changes in inner hair cell ribbon synapses in the ageing mammalian cochlea	22
Orexin neurons and inhibitory Agrp→orexin circuits guide spatial exploration in mice	22
Brainstem inflammation modulates the ventilatory pattern and its variability after acute lung injury in rodents	22
Regulation of muscle and mitochondrial health by the mitochondrial fission protein Drp1 in aged mice	21
Abnormal skeletal muscle blood flow, contractile mechanics and fibre morphology in a rat model of obese‐HFpEF	21
Time‐dependent changes in autophagy, mitophagy and lysosomes in skeletal muscle during denervation‐induced disuse	21
NMDA receptors in axons: there's no coincidence	21
Peripheral impairments of oxidative metabolism after a 10‐day bed rest are upstream of mitochondrial respiration	21
The effect of lifelong endurance exercise on cardiovascular structure and exercise function in women	21
Steady‐state sweating during exercise is determined by the evaporative requirement for heat balance independently of absolute core and skin temperatures	21
Abnormal placental CD8+ T‐cell infiltration is a feature of fetal growth restriction and pre‐eclampsia	21
Arterial carbon dioxide and bicarbonate rather than pH regulate cerebral blood flow in the setting of acute experimental metabolic alkalosis	21
Single muscle fibre contractile function with ageing	21
Inhaled nitric oxide improves ventilatory efficiency and exercise capacity in patients with mild COPD: A randomized‐control cross‐over trial	20
Peroxisomal proliferator‐activated receptor α‐b deficiency induces the reprogramming of nutrient metabolism in zebrafish	20
Spinal motoneuron firing properties mature from rostral to caudal during postnatal development of the mouse	20
Amyloid Beta42 oligomers up‐regulate the excitatory synapses by potentiating presynaptic release while impairing postsynaptic NMDA receptors	20
Differential effects of motor skill acquisition on the primary motor and sensory cortices in healthy humans	20
Physiological aspects of cardiopulmonary dysanapsis on exercise in adults born preterm	20
Nitric oxide contributes to cerebrovascular shear‐mediated dilatation but not steady‐state cerebrovascular reactivity to carbon dioxide	20
Ketamine anaesthesia induces gain enhancement via recurrent excitation in granular input layers of the auditory cortex	20
Zona incerta neurons projecting to the ventral tegmental area promote action initiation towards feeding	20
Regulation of glutamate receptors by striatal‐enriched tyrosine phosphatase 61 (STEP61)	20
Neuronal HIF‐1α in the nucleus tractus solitarius contributes to ventilatory acclimatization to hypoxia	19
The role of mitochondria in metabolic disease: a special emphasis on heart dysfunction	19
The suitability of high throughput automated patch clamp for physiological applications	19
Exposure to high fructose corn syrup during adolescence in the mouse alters hepatic metabolism and the microbiome in a sex‐specific manner	19
Facilitation–inhibition control of motor neuronal persistent inward currents in young and older adults	19

Intermuscular coherence analysis in older adults reveals that gait‐related arm swing drives lower limb muscles via subcortical and cortical pathways	19
Fetal growth, birth size and energetic cost of gestation in southern right whales	19
Correlation networks of spinal motor neurons that innervate lower limb muscles during a multi‐joint isometric task	19
Effects of short‐term unloading and active recovery on human motor unit properties, neuromuscular junction transmission and transcriptomic profile	19
Time‐restricted feeding combined with aerobic exercise training can prevent weight gain and improve metabolic disorders in mice fed a high‐fat diet	19
Near‐infrared spectroscopy estimation of combined skeletal muscle oxidative capacity and O2 diffusion capacity in humans	19
PKCε stimulation of TRPV1 orchestrates carotid body responses to asthmakines	19
Neuronal hypertrophy dampens neuronal intrinsic excitability and stress responsiveness during chronic stress	18
Publications, replication and statistics in physiology plus two neglected curves	18
Hypothalamic–vagal oxytocinergic neurocircuitry modulates gastric emptying and motility following stress	18
Junctophilin‐4 facilitates inflammatory signalling at plasma membrane‐endoplasmic reticulum junctions in sensory neurons	18
Nitrate attenuates high fat diet‐induced glucose intolerance in association with reduced epididymal adipose tissue inflammation and mitochondrial reactive oxygen species emission	18
Exosome engineering for efficient and targeted drug delivery: Current status and future perspective	18
Ageing and exercise‐induced motor unit remodelling	18
Functional development and regeneration of hair cells in the zebrafish lateral line	18
Maternal obesity causes fetal cardiac hypertrophy and alters adult offspring myocardial metabolism in mice	18
Nutrient timing and metabolic regulation	18
Maternal exercise attenuates the lower skeletal muscle glucose uptake and insulin secretion caused by paternal obesity in female adult rat offspring	18
CrossTalk opposing view: NKCC1 in the luminal membrane of choroid plexus is outwardly directed under basal conditions and contributes directly to cerebrospinal fluid secretion	18
Location, location, location: the organization and roles of potassium channels in mammalian motoneurons	18
Influence of blood flow occlusion on muscular recruitment and fatigue during maximal‐effort small muscle‐mass exercise	18
Interpreting ‘anti‐inflammatory’ cytokine responses to exercise: focus on interleukin‐10	18
Presynaptic development is controlled by the core active zone proteins CAST/ELKS	18
Biological sex, not reproductive cycle, influences peripheral blood immune cell prevalence in mice	18
Modulation of cortical slow oscillatory rhythm by GABAB receptors: an in vitro experimental and computational study	18
Rapid volume pulsation of the extracellular space coincides with epileptiform activity in mice and depends on the NBCe1 transporter	17
Adipocyte function and the development of cardiometabolic disease	17
Na+ is shifted from the extracellular to the intracellular compartment and is not inactivated by glycosaminoglycans during high salt conditions in rats	17
Influence of iron manipulation on hypoxic pulmonary vasoconstriction and pulmonary reactivity during ascent and acclimatization to 5050 m	17
Biological validation of electron paramagnetic resonance (EPR) image oxygen thresholds in tissue	17
Divergent immunometabolic changes in adipose tissue and skeletal muscle with ageing in healthy humans	17
Enhancing responsiveness of human jejunal enteroids to host and microbial stimuli	17
Oxytocin receptors excite lateral nucleus of central amygdala by phospholipase Cβ‐ and protein kinase C‐dependent depression of inwardly rectifying K+ channels	17
Abnormal cerebellar function and tremor in a mouse model for non‐manifesting partially penetrant dystonia type 6	17
Beetroot juice lowers blood pressure and improves endothelial function in pregnant eNOS−/− mice: importance of nitrate‐independent effects	17
Circadian actions of orexins on the retinorecipient lateral geniculate complex in rat	17
Role of pattern recognition receptors and the microbiota in neurological disorders	17
Desmin prevents muscle wasting, exaggerated weakness and fragility, and fatigue in dystrophic mdx mouse	17
How does oxygen diffuse from capillaries to tissue mitochondria? Barriers and pathways	17
Blockade of 5‐HT2 receptors suppresses motor unit firing and estimates of persistent inward currents during voluntary muscle contraction in humans	17
Bugs, breathing and blood pressure: microbiota–gut–brain axis signalling in cardiorespiratory control in health and disease	17
Evidence for multiple bulbar and higher brain circuits processing sensory inputs from the respiratory system in humans	17
Oxygenation pattern and compensatory responses to hypoxia and hypercapnia following bilateral carotid body resection in humans	17
The effects of maternal position, in late gestation pregnancy, on placental blood flow and oxygenation: an MRI study	17
The capillary fascicle in skeletal muscle: Structural and functional physiology of RBC distribution in capillary networks	17
Increased skin wetness independently augments cool‐seeking behaviour during passive heat stress	16
Feasibility of ventricular volumetry by cardiovascular MRI to assess cardiac function in the fetal sheep	16
Increasing SERCA function promotes initiation of calcium sparks and breakup of calcium waves	16
Influence of the mode of heating on cerebral blood flow, non‐invasive intracranial pressure and thermal tolerance in humans	16
Muscle BDNF improves synaptic and contractile muscle strength in Kennedy's disease mice in a muscle‐type specific manner	16
Electrophysiological significance of the interatrial conduction including cavo‐tricuspid isthmus during atrial fibrillation	16
Disproportionate loss of excitatory inputs to smaller phrenic motor neurons following cervical spinal hemisection	16
Modelling unitary fields and the single‐neuron contribution to local field potentials in the hippocampus	16
NAD+ and NAFLD – caution, causality and careful optimism	16
Vagus nerve stimulation activates nucleus of solitary tract neurons via supramedullary pathways	16
Motor unit dysregulation following 15 days of unilateral lower limb immobilisation	16
Acid–base balance and cerebrovascular regulation	16
GluN3A NMDA receptor subunits: more enigmatic than ever?	16
Fungal allergen‐induced IL‐33 secretion involves cholesterol‐dependent, VDAC‐1‐mediated ATP release from the airway epithelium	16
Optogenetic approaches to therapy for inherited retinal degenerations	16
Rapamycin and mTORC2 inhibition synergistically reduce contraction‐stimulated muscle protein synthesis	16
Naked mole‐rat brain mitochondria tolerate in vitro ischaemia	16
Intrinsic and synaptic mechanisms controlling the expiratory activity of excitatory lateral parafacial neurones of rats	16
Greater exercise tolerance in COPD during acute interval, compared to equivalent constant‐load, cycle exercise: physiological mechanisms	16
An MRI approach to assess placental function in healthy humans and sheep	16
Glial amplification of synaptic signals	16
Structural basis for positive allosteric modulation of AMPA and kainate receptors	16
A role for neurokinin 1 receptor expressing neurons in the paratrigeminal nucleus in bradykinin‐evoked cough in guinea‐pigs	16
Contraction‐regulated mTORC1 and protein synthesis: Influence of AMPK and glycogen	15
Remote ischaemic preconditioning – translating cardiovascular benefits to humans	15
Physiological roles of heteromerization: focus on the two‐pore domain potassium channels	15
Placental fatty acid transport across late gestation in a baboon model of intrauterine growth restriction	15
Oxidant‐resistant LRRC8A/C anion channels support superoxide production by NADPH oxidase 1	15
Endocytic adaptation to functional demand by the kidney proximal tubule	15
Oxidative ATP synthesis in human quadriceps declines during 4 minutes of maximal contractions	15
Resilience of neural networks for locomotion	15
Heterogeneous baroreflex control of sympathetic action potential subpopulations in humans	15
Regulation of cardiovascular health and disease by visceral adipose tissue‐derived metabolic hormones	15
Sex differences in diaphragmatic fatigue: Effects of hypoxia during inspiratory loading	15
Selective activation of BK channels in small‐headed dendritic spines suppresses excitatory postsynaptic potentials	15
Exercise training remodels subcutaneous adipose tissue in adults with obesity even without weight loss	15
‘Resistance is futile?’ – paradoxical inhibitory effects of KATP channel closure in glucagon‐secreting α‐cells	15
Acute reductions in haematocrit increase flow‐mediated dilatation independent of resting nitric oxide bioavailability in humans	15
Limited capacity for ipsilateral secondary motor areas to support hand function post‐stroke	15
Transcapillary PO2 gradients in contracting muscles across the fibre type and oxidative continuum	15
Preserved stem cell content and innervation profile of elderly human skeletal muscle with lifelong recreational exercise	15
Gut peptide regulation of food intake – evidence for the modulation of hedonic feeding	15
Divergent splanchnic sympathetic efferent nerve pathways regulate interleukin‐10 and tumour necrosis factor‐α responses to endotoxaemia	15
Quantification of cardiac and respiratory modulation of axonal activity in the human vagus nerve	15
Phenotyping heart failure using model‐based analysis and physiology‐informed machine learning	15
Maternal but not fetoplacental health can be improved by metformin in a murine diet‐induced model of maternal obesity and glucose intolerance	15
Sex differences in the sympathetic neurocirculatory responses to chemoreflex activation	15
What gets on the nerves of cardiac patients? Pathophysiological changes in cardiac innervation	15
Inflammatory gene expression during acute high‐altitude exposure	15
Carbohydrate improves exercise capacity but does not affect subcellular lipid droplet morphology, AMPK and p53 signalling in human skeletal muscle	15