Journal of Pharmacy and Pharmacology

Article	Citations
Tetrandrine: a review of its anticancer potentials, clinical settings, pharmacokinetics and drug delivery systems	72
Benzothiazoles as potential antiviral agents	64
Hypericin-mediated photodynamic therapy for the treatment of cancer: a review	51
Propolis antiviral and immunomodulatory activity: a review and perspectives for COVID-19 treatment	48
Efficiency comparison of apigenin-7-O-glucoside and trolox in antioxidative stress and anti-inflammatory properties	44
Vesicular drug delivery for the treatment of topical disorders: current and future perspectives	39
Modulation of NADPH oxidase and Nrf2/HO-1 pathway by vanillin in cisplatin-induced nephrotoxicity in rats	36
Isatis indigotica: a review of phytochemistry, pharmacological activities and clinical applications	36
p-Coumaric acid mitigates lipopolysaccharide induced brain damage via alleviating oxidative stress, inflammation and apoptosis	35
Pharmacological postconditioning: a molecular aspect in ischemic injury	33
A selanylimidazopyridine (3-SePh-IP) reverses the prodepressant- and anxiogenic-like effects of a high-fat/high-fructose diet in mice	31
Rutin prevents inflammation induced by lipopolysaccharide in RAW 264.7 cells via conquering the TLR4-MyD88-TRAF6-NF-κB signalling pathway	31
Gallic acid attenuates isoniazid and rifampicin-induced liver injury by improving hepatic redox homeostasis through influence on Nrf2 and NF-κB signalling cascades in Wistar Rats	31
Doxorubicin-induced cardiotoxicity: causative factors and possible interventions	30
Azadirachta indica A. Juss (neem) against diabetes mellitus: a critical review on its phytochemistry, pharmacology, and toxicology	29
Narrow Therapeutic Index drugs: clinical pharmacology perspective	28
Remimazolam alleviates neuropathic pain via regulating bradykinin receptor B1 and autophagy	25
Ruscogenin attenuates sepsis-induced acute lung injury and pulmonary endothelial barrier dysfunction via TLR4/Src/p120-catenin/VE-cadherin signalling pathway	24
Quinones as preventive agents in Alzheimer’s diseases: focus on NLRP3 inflammasomes	24
Zinc oxide nanoparticles synthesized from Aspergillus terreus induces oxidative stress-mediated apoptosis through modulating apoptotic proteins in human cervical cancer HeLa cells	23
Purpurin, a anthraquinone induces ROS-mediated A549 lung cancer cell apoptosis via inhibition of PI3K/AKT and proliferation	22
Moringa oleifera: a systematic review of its botany, traditional uses, phytochemistry, pharmacology and toxicity	22
Genus Lupinus (Fabaceae): a review of ethnobotanical, phytochemical and biological studies	22
The role of microRNAs on doxorubicin drug resistance in breast cancer	22
Development of 3D printed drug-eluting contact lenses	22

Steroidal saponins from Trillium govanianum as α-amylase, α-glucosidase, and dipeptidyl peptidase IV inhibitory agents	21
Ginsenoside Rg3 ameliorates acetaminophen-induced hepatotoxicity by suppressing inflammation and oxidative stress	21
Xanthohumol ameliorates memory impairment and reduces the deposition of β-amyloid in APP/PS1 mice via regulating the mTOR/LC3II and Bax/Bcl-2 signalling pathways	20
Paeoniflorin modulates oxidative stress, inflammation and hepatic stellate cells activation to alleviate CCl4-induced hepatic fibrosis by upregulation of heme oxygenase-1 in mice	20
A cut above the rest: oxidative stress in chronic wounds and the potential role of polyphenols as therapeutics	19
Ephedra sinica polysaccharide alleviates airway inflammations of mouse asthma-like induced by PM2.5 and ovalbumin via the regulation of gut microbiota and short chain fatty acid	19
Rhamnetin: a review of its pharmacology and toxicity	18
Treatment of liver cancer cells with ethyl acetate extract of Crithmum maritimum permits reducing sorafenib dose and toxicity maintaining its efficacy	18
Augmented cytotoxicity using the physical adsorption of Poloxamer 188 on allicin-loaded gelatin nanoparticles	17
Propolis from southeastern Brazil produced by Apis mellifera affects innate immunity by modulating cell marker expression, cytokine production and intracellular pathways in human monocytes	17
Crude polysaccharide from the milky mushroom, Calocybe indica, modulates innate immunity of macrophage cells by triggering MyD88-dependent TLR4/NF-κB pathway	16
Xanthone-enriched fraction of Garcinia mangostana and α-mangostin improve the spatial learning and memory of chronic cerebral hypoperfusion rats	16
Semi-solid extrusion 3D printing of starch-based soft dosage forms for the treatment of paediatric latent tuberculosis infection	16
A review on phytochemical and therapeutic potential of Iris germanica	16
Studies on the compatibility mechanism and material basis of Danggui Buxue Decoction against anemia mice using metabonomics and network pharmacology	16
Chrysophanol exerts neuroprotective effects via interfering with endoplasmic reticulum stress apoptotic pathways in cell and animal models of Alzheimer’s disease	16
Jatrorrhizine: a review of its pharmacological effects	15
Insulinotropic and antidiabetic properties of Eucalyptus citriodora leaves and isolation of bioactive phytomolecules	15
Atractylodin inhibited the migration and induced autophagy in cholangiocarcinoma cells via PI3K/AKT/mTOR and p38MAPK signalling pathways	15
Research progress of pharmacological effects of Siraitia grosvenorii extract	15
Phytochemicals in traditional Chinese medicine can treat gout by regulating intestinal flora through inactivating NLRP3 and inhibiting XOD activity	15
Modulation of multiple cellular signalling pathways as targets for anti-inflammatory and anti-tumorigenesis action of Scopoletin	15
Improvement of the bioavailability of curcumin by a supersaturatable self nanoemulsifying drug delivery system with incorporation of a hydrophilic polymer: in vitro and in vivo character	15
Ganoderma lucidum ameliorates the diabetic nephropathy via down-regulatory effect on TGFβ-1 and TLR-4/NFκB signalling pathways	15
Black mulberry fruit extract alleviates streptozotocin-induced diabetic nephropathy in rats: targeting TNF-α inflammatory pathway	15
Bile acid sequestrants: a review of mechanism and design	15
Retracted: Inhibiting the PI3K/Akt, NF-κB signalling pathways with syringic acid for attenuating the development of oral squamous cell carcinoma cells SCC131	15
Modulation of NF-κB and MAPK signalling pathways by hydrolysable tannin fraction from Terminalia chebula fruits contributes to its anti-inflammatory action in RAW 264.7 cells	15
Cissus quadrangularis extract attenuates diabetic nephropathy by altering SIRT1/DNMT1 axis	15
Combining combretastatin A4 phosphate with ginsenoside Rd synergistically inhibited hepatocellular carcinoma by reducing HIF-1α via PI3K/AKT/mTOR signalling pathway	14
Lupeol induces autophagy and apoptosis with reduced cancer stem-like properties in retinoblastoma via phosphoinositide 3-kinase/protein kinase B/mammalian target of rapamycin inhibition	14
Neuroprotective effects of synthetic borneol and natural borneol based on the neurovascular unit against cerebral ischaemic injury	14
Rosmarinic acid ameliorates septic-associated mortality and lung injury in mice via GRP78/IRE1α/JNK pathway	14
An in vitro study on the reversal of epithelial to mesenchymal transition by brusatol and its synergistic properties in triple-negative breast cancer cells	14
Fructus arctii: an overview on its traditional uses, pharmacology and phytochemistry	14
Pharmacokinetics-based chronoefficacy of Fuzi against chronic kidney disease	14
Nutritional benefits, ethnomedicinal uses, phytochemistry, pharmacological properties and toxicity of Spondias mombin Linn: a comprehensive review	13
Environmental toxicants, oxidative stress and health adversities: interventions of phytochemicals	13
3D Printing: an appealing technology for the manufacturing of solid oral dosage forms	13
Functionalised molybdenum disulfide nanosheets for co-delivery of doxorubicin and siRNA for combined chemo/gene/photothermal therapy on multidrug-resistant cancer	13
Preparation of loratadine nanocrystal tablets to improve the solubility and dissolution for enhanced oral bioavailability	13
Near-infrared spectroscopy and HPLC combined with chemometrics for comprehensive evaluation of six organic acids in Ginkgo biloba leaf extract	13
Isoliquiritigenin attenuates inflammation and modulates Nrf2/caspase-3 signalling in STZ-induced aortic injury	13
Cordycepin induces M1/M2 macrophage polarization to attenuate the liver and lung damage and immunodeficiency in immature mice with sepsis via NF-κB/p65 inhibition	13
A review of anti-tumour effects of ginsenoside in gastrointestinal cancer	13
The potential of Ginkgo biloba in the treatment of human diseases and the relationship to Nrf2–mediated antioxidant protection	13
VX-765 ameliorates inflammation and extracellular matrix accumulation by inhibiting the NOX1/ROS/NF-κB pathway in diabetic nephropathy	12
Silencing of SNHG6 alleviates hypoxia/reoxygenation-induced cardiomyocyte apoptosis by modulating miR-135a-5p/HIF1AN to activate Shh/Gli1 signalling pathway	12
A honokiol-enriched Magnolia officinalis Rehder & E.H. Wilson. bark extract possesses anxiolytic-like activity with neuroprotective effect through the modulation of CB1 receptor	12
Antiviral activity against Zika virus of a new formulation of curcumin in poly lactic-co-glycolic acid nanoparticles	12

Interferon regulatory factor 6 correlates with the progression of non-small cell lung cancer and can be regulated by miR-320	12
Sodium hydrogen sulfide upregulates cystathionine β-synthase and protects striatum against 3-nitropropionic acid-induced neurotoxicity in rats	12
Cilostazol attenuated prenatal valproic acid-induced behavioural and biochemical deficits in a rat model of autism spectrum disorder	12
Dietary supplements and medicinal plants in urolithiasis: diet, prevention, and cure	12
Abrogation of STAT3 activation cascade by Ginkgolide C mitigates tumourigenesis in lung cancer preclinical model	12
Dysregulation of tyrosinase activity: a potential link between skin disorders and neurodegeneration	12
Improvement of the pharmacokinetic characteristics of liposomal doxorubicin using CD47 biomimickry	12
Mechanisms exploration of Xiaojin Pills on lung cancer based on metabolomics and network pharmacology	12
Medicinal plants from the Himalayan region for potential novel antimicrobial and anti-inflammatory skin treatments	12
Umbelliferone ameliorates oxidative stress and testicular injury, improves steroidogenesis and upregulates peroxisome proliferator-activated receptor gamma in type 2 diabetic rats	12
Caffeic acid regulates glucose homeostasis and inhibits purinergic and cholinergic activities while abating oxidative stress and dyslipidaemia in fructose-streptozotocin-induced diabetic rats	11
Natural substances derived from herbs or plants are promising sources of anticancer agents against colorectal cancer via triggering apoptosis	11
Effect of Hibiscus sabdariffa and Zingiber officinale on pharmacokinetics and pharmacodynamics of amlodipine	11
Glucosamine attenuates drug resistance in Mitoxantrone-resistance breast cancer cells	11
Comparative bioavailability of curcuminoids from a water-dispersible high curcuminoid turmeric extract against a generic turmeric extract: a randomized, cross-over, comparative, pharmacokinetic study	11
Exosome-like nanoparticles derived from Allium tuberosum prevent neuroinflammation in microglia-like cells	11
Fluvastatin protects neuronal cells from hydrogen peroxide-induced toxicity with decreasing oxidative damage and increasing PI3K/Akt/mTOR signalling	11
The traditional uses, phytochemistry, pharmacology and toxicology of Dictamnus dasycarpus: a review	11
Zanthoxylum zanthoxyloides inhibits lipopolysaccharide- and synthetic hemozoin-induced neuroinflammation in BV-2 microglia: roles of NF-κB transcription factor and NLRP3 inflammasome activation	11
Triterpenoid compound betulin attenuates allergic airway inflammation by modulating antioxidants, inflammatory cytokines and tissue transglutaminase in ovalbumin-induced asthma mice model	11
Vanillic acid–Zn(II) complex: a novel complex with antihyperglycaemic and anti-oxidative activity	11
Long noncoding RNA HOXA-AS2 accelerates cervical cancer by the miR-509-3p/BTN3A1 axis	11
Berberine inhibits tumour growth in vivo and in vitro through suppressing the lincROR-Wnt/β-catenin regulatory axis in colorectal cancer	11
Alamandine protects against renal ischaemia–reperfusion injury in rats via inhibiting oxidative stress	11
Development of a comprehensive method based on quantitative 1H NMR for quality evaluation of Traditional Chinese Medicine injection: a case study of Danshen Injection	10
The promising application of hydrogel microneedles in medical application	10
Circ_UTRN ameliorates caerulein-induced acute pancreatitis in vitro via reducing inflammation and promoting apoptosis through miR-320-3p/PTK2 axis	10
Clock gene Bmal1 controls diurnal rhythms in expression and activity of intestinal carboxylesterase 1	10
Repurposing of sildenafil as antitumour; induction of cyclic guanosine monophosphate/protein kinase G pathway, caspase-dependent apoptosis and pivotal reduction of Nuclear factor kappa light chain enh	10
Genus Barleria L. (Acanthaceae): a review of its taxonomy, cytogenetics, phytochemistry and pharmacological potential	10
An in vitro evaluation of antitumor activity of sirolimus-encapsulated liposomes in breast cancer cells	10
Specnuezhenide reduces carbon tetrachloride-induced liver injury in mice through inhibition of oxidative stress and hepatocyte apoptosis	10
Scrophularia ningpoensis Hemsl: a review of its phytochemistry, pharmacology, quality control and pharmacokinetics	10
Ameliorative effects of garlic oil on FNDC5 and irisin sensitivity in liver of streptozotocin-induced diabetic rats	10
Remifentanil protects heart from myocardial ischaemia/reperfusion (I/R) injury via miR-206-3p/TLR4/NF-κB signalling axis	10
Nrf2 signalling pathway and autophagy impact on the preventive effect of green tea extract against alcohol-induced liver injury	10
A comparative study between curcumin and curcumin nanoemulsion on high-fat, high-fructose diet-induced impaired spermatogenesis in rats	10
l-Borneol ameliorates cerebral ischaemia by downregulating the mitochondrial calcium uniporter-induced apoptosis cascade in pMCAO rats	10
Botany, traditional uses, phytochemistry and pharmacological activity of Crataegus pinnatifida (Chinese hawthorn): a review	10
Protective effects of duloxetine against chronic immobilisation stress-induced anxiety, depression, cognitive impairment and neurodegeneration in mice	10
Azilsartan ameliorates ventricular hypertrophy in rats suffering from pressure overload-induced cardiac hypertrophy by activating the Keap1–Nrf2 signalling pathway	9
Eplerenone reduces renal ischaemia/reperfusion injury by modulating Klotho, NF-κB and SIRT1/SIRT3/PGC-1α signalling pathways	9
Pharmacological and phytochemical potential of Rubus ellipticus: a wild edible with multiple health benefits	9
Spinosin protects N2a cells from H2O2-induced neurotoxicity through inactivation of p38MAPK	9
Cell-penetrating peptide-mediated delivery of therapeutic peptides/proteins to manage the diseases involving oxidative stress, inflammatory response and apoptosis	9
Pharmacological intervention in oxidative stress as a therapeutic target in neurological disorders	9
Effect of genipin-1-β-d-gentiobioside on diabetic nephropathy in mice by activating AMP-activated protein kinase/silencing information regulator-related enzyme 1/ nuclear factor-κB pathway	9
Tangeretin as an adjuvant and chemotherapeutic sensitizer against various types of cancers: a comparative overview	9
Toll-like receptor-7/8 agonist kill Leishmania amazonensis by acting as pro-oxidant and pro-inflammatory agent	9
Combination of urine and faeces metabolomics to reveal the intervention mechanism of Polygala tenuifolia compatibility with Magnolia officinalis on gastrointestinal motility disorders	9
Performance and paroxetine stability in tablets manufactured by fused deposition modelling-based 3D printing	9
Anti-inflammatory, anti-oxidant and anti-apoptotic effects of olive leaf extract in cardiac tissue of diabetic rats	9
New insights into the effects of vinpocetine against neurobehavioral comorbidities in a rat model of temporal lobe epilepsy via the downregulation of the hippocampal PI3K/mTOR signalling pathway	9
The development and optimisation of gastro-retentive floating tablets using fused deposition modelling 3D printing	9
Eugenol modulates insulin sensitivity by upregulating insulin receptor substrate-2 in non-alcoholic fatty liver disease in rats	9
Inhibition of p90 ribosomal S6 kinase potentiates cisplatin activity in A549 human lung adenocarcinoma cells	9
PI3K/AKT/Nrf2 signalling pathway is involved in the ameliorative effects of xanthohumol on amyloid β-induced oxidative damage and bone loss	9
β-Caryophyllene attenuates lipopolysaccharide-induced acute lung injury via inhibition of the MAPK signalling pathway	9
Targeted delivery and apoptosis induction activity of peptide-transferrin targeted mesoporous silica encapsulated resveratrol in MCF-7 cells	8
α-Glucosidase and advanced glycation end products inhibition with Vernonia amygdalina root and leaf extracts: new data supporting the antidiabetic properties	8
Inula japonica ameliorated the inflammation and oxidative stress in LPS-induced acute lung injury through the MAPK/NF-κB and Keap1/Nrf2 signalling pathways	8
Evaluation of the effects of nanoparticles on the therapeutic function of platelet: a review	8
β-Cyclodextrin-containing chitosan-oligonucleotide nanoparticles improve insulin bioactivity, gut cellular permeation and glucose consumption	8
Bromelain ameliorates D-galactosamine-induced acute liver injury: role of SIRT1/LKB1/AMPK, GSK3β/Nrf2 and NF-κB p65/TNF-α/caspase-8, -9 signalling pathways	8
Distinct metabonomic signatures of Polygoni Multiflori Radix Praeparata against glucolipid metabolic disorders	8
Grape seed extract improved the fertility-enhancing effect of atorvastatin in high-fat diet-induced testicular injury in rats: involvement of antioxidant and anti-apoptotic effects	8
Oral biopharmaceutics tools: recent progress from partnership through the Pharmaceutical Education and Research with Regulatory Links collaboration	8
The role of lncRNA ANRIL in the progression of hepatocellular carcinoma	8
Icariin ameliorates partial sciatic nerve ligation induced neuropathic pain in rats: an evidence of in silico and in vivo studies	8
The Protective Effect of Natural Compounds on Doxorubicin-Induced Cardiotoxicity via Nicotinamide Adenine Dinucleotide Phosphate Oxidase Inhibition	8
Cannabidiol prevents chemotherapy-induced neuropathic pain by modulating spinal TLR4 via endocannabinoid system activation	8
Protective effect of flavonoids from Passiflora edulis Sims on diabetic complications in rats	8
Preparation and evaluation of reduction-responsive micelles based on disulfide-linked chondroitin sulfate A-tocopherol succinate for controlled antitumour drug release	8
Cytotoxicity mechanisms of plumbagin in drug-resistant tongue squamous cell carcinoma	7
Kaempferitrin, a major compound from ethanol extract of Chenopodium ambrosioides, exerts antitumour and hepatoprotective effects in the mice model of human liver cancer xenografts	7
Short overview on the relevance of microRNA–reactive oxygen species (ROS) interactions and lipid peroxidation for modulation of oxidative stress-mediated signalling pathways in cancer treatment	7
The methanol extract of red algae, Dichotomaria obtusata, from Persian Gulf promotes in vitro osteogenic differentiation of bone marrow mesenchymal stem cells; a biological and phytochem	7
Shaoyao Gancao Decoction protects against dextran sulfate sodium-induced ulcerative colitis by down-regulating ferroptosis	7
Research progress regarding potential effects of traditional Chinese medicine on postoperative intestinal obstruction	7
Effects of minocycline on motor function recovery and expression of glial fibrillary acidic protein and brain-derived neurotrophic factor after spinal cord injury in rats	7

Stereolithography-assisted fabrication of 3D printed polymeric film for topical berberine delivery: in-vitro, ex-vivo and in-vivo investigations	7
Glochidion ellipticum Wight extracts ameliorate dextran sulfate sodium-induced colitis in mice by modulating nuclear factor kappa-light-chain-enhancer of activated B cells signalling pathway	7
Chlorogenic acid ameliorates mice clinical endometritis by activating Keap1/Nrf2 and inhibiting NFκB signalling pathway	7
Long non-coding RNA HLA complex group 18 promotes gastric cancer progression by targeting microRNA-370-3p expression	7
Epigallocatechin gallate alters leukotoxin secretion and Aggregatibacter actinomycetemcomitans virulence	7
Dioscorea zingiberensis ameliorates diabetic nephropathy by inhibiting NLRP3 inflammasome and curbing the expression of p66Shc in high-fat diet/streptozotocin-induced diabetic mice	7
Potential therapeutic efficacy of pachymic acid in chronic kidney disease induced in rats: role of Wnt/β-catenin/renin–angiotensin axis	7
Novel therapeutic approaches for Parkinson’s disease by targeting brain cholesterol homeostasis	7
The phytochemistry and biological diversity of Ferulago genus (Apiaceae): a systematic review	7
Flavonoids as new regulators of mitochondrial potassium channels: contribution to cardioprotection	7
Curcumae Radix: a review of its botany, traditional uses, phytochemistry, pharmacology and toxicology	7
Natural flavonolignans as potential therapeutic agents against common diseases	7
1,8-cineole ameliorates ischaemic brain damage via TRPC6/CREB pathways in rats	7
Systemic administration of sunflower oil exerts neuroprotection in a mouse model of transient focal cerebral ischaemia	7
TheClockgene regulates kainic acid-induced seizures through inhibiting ferroptosis in mice	7
Aprepitant: an antiemetic drug, contributes to the prevention of acute lung injury with its anti-inflammatory and antioxidant properties	7
Barbaloin attenuates pulmonary fibrosis through TGF-β1/Smads/p38 pathway	7
Flavonoids and saponins from Passiflora edulis f. edulis leaves (purple passion fruit) and its potential anti-inflammatory activity	7