Journal of Pharmacy and Pharmacology

Article	Citations
Drug repositioning: a brief overview	184
Tetrandrine: a review of its anticancer potentials, clinical settings, pharmacokinetics and drug delivery systems	62
Recent trends in targeting miRNAs for cancer therapy	62
Benzothiazoles as potential antiviral agents	56
C2C12 cell model: its role in understanding of insulin resistance at the molecular level and pharmaceutical development at the preclinical stage	52
Medicinal plants used against various inflammatory biomarkers for the management of rheumatoid arthritis	50
Propolis antiviral and immunomodulatory activity: a review and perspectives for COVID-19 treatment	43
Efficiency comparison of apigenin-7-O-glucoside and trolox in antioxidative stress and anti-inflammatory properties	39
Hypericin-mediated photodynamic therapy for the treatment of cancer: a review	39
Modulation of NADPH oxidase and Nrf2/HO-1 pathway by vanillin in cisplatin-induced nephrotoxicity in rats	33
Vesicular drug delivery for the treatment of topical disorders: current and future perspectives	31
p-Coumaric acid mitigates lipopolysaccharide induced brain damage via alleviating oxidative stress, inflammation and apoptosis	30
Green synthesis of gold nanoparticles by using Ferula persica Willd. gum essential oil: production, characterization and in vitro anti-cancer effects	27
Pharmacological postconditioning: a molecular aspect in ischemic injury	27
Rutin prevents inflammation induced by lipopolysaccharide in RAW 264.7 cells via conquering the TLR4-MyD88-TRAF6-NF-κB signalling pathway	27
Isatis indigotica: a review of phytochemistry, pharmacological activities and clinical applications	27
A selanylimidazopyridine (3-SePh-IP) reverses the prodepressant- and anxiogenic-like effects of a high-fat/high-fructose diet in mice	25
Nose-to-brain delivery of sumatriptan-loaded nanostructured lipid carriers: preparation, optimization, characterization and pharmacokinetic evaluation	23
Azadirachta indica A. Juss (neem) against diabetes mellitus: a critical review on its phytochemistry, pharmacology, and toxicology	23
Scalable solvent-free production of liposomes	22
Quinones as preventive agents in Alzheimer’s diseases: focus on NLRP3 inflammasomes	22
Gallic acid attenuates isoniazid and rifampicin-induced liver injury by improving hepatic redox homeostasis through influence on Nrf2 and NF-κB signalling cascades in Wistar Rats	22
Pinoresinol-4-O-β-D-glucopyranoside: a lignan from prunes (Prunus domestica) attenuates oxidative stress, hyperglycaemia and hepatic toxicity in vitro and in vivo	21
Metformin inhibits extracellular matrix accumulation, inflammation and proliferation of mesangial cells in diabetic nephropathy by regulating H19/miR-143-3p/TGF-β1 axis	20
Narrow Therapeutic Index drugs: clinical pharmacology perspective	19

Design of enamides as new selective monoamine oxidase-B inhibitors	18
Curcumin alleviates OGD/R-induced PC12 cell damage via repressing CCL3 and inactivating TLR4/MyD88/MAPK/NF-κB to suppress inflammation and apoptosis	18
Bioactive indanes: insight into the bioactivity of indane dimers related to the lead anti-inflammatory molecule PH46A	17
The role of microRNAs on doxorubicin drug resistance in breast cancer	17
Ruscogenin attenuates sepsis-induced acute lung injury and pulmonary endothelial barrier dysfunction via TLR4/Src/p120-catenin/VE-cadherin signalling pathway	17
Doxorubicin-induced cardiotoxicity: causative factors and possible interventions	17
Paeoniflorin modulates oxidative stress, inflammation and hepatic stellate cells activation to alleviate CCl4-induced hepatic fibrosis by upregulation of heme oxygenase-1 in mice	17
Synthesis, characterization, antidiabetic and antioxidative evaluation of a novel Zn(II)-gallic acid complex with multi-facet activity	17
Astragaloside IV ameliorates radiation-induced senescence via antioxidative mechanism	16
Ginsenoside Rg3 ameliorates acetaminophen-induced hepatotoxicity by suppressing inflammation and oxidative stress	16
Treatment of liver cancer cells with ethyl acetate extract of Crithmum maritimum permits reducing sorafenib dose and toxicity maintaining its efficacy	16
Purpurin, a anthraquinone induces ROS-mediated A549 lung cancer cell apoptosis via inhibition of PI3K/AKT and proliferation	16
Remimazolam alleviates neuropathic pain via regulating bradykinin receptor B1 and autophagy	16
Rhamnetin: a review of its pharmacology and toxicity	16
Propolis from southeastern Brazil produced by Apis mellifera affects innate immunity by modulating cell marker expression, cytokine production and intracellular pathways in human monocytes	16
Zinc oxide nanoparticles synthesized from Aspergillus terreus induces oxidative stress-mediated apoptosis through modulating apoptotic proteins in human cervical cancer HeLa cells	16
Encapsulation of curcumin into layered double hydroxides improve their anticancer and antiparasitic activity	15
Tectorigenin inhibits inflammation and pulmonary fibrosis in allergic asthma model of ovalbumin-sensitized guinea pigs	15
Development of 3D printed drug-eluting contact lenses	15
Xanthohumol ameliorates memory impairment and reduces the deposition of β-amyloid in APP/PS1 mice via regulating the mTOR/LC3II and Bax/Bcl-2 signalling pathways	15
Acacetin inhibits Streptococcus pneumoniae virulence by targeting pneumolysin	15
Genus Lupinus (Fabaceae): a review of ethnobotanical, phytochemical and biological studies	14
A cut above the rest: oxidative stress in chronic wounds and the potential role of polyphenols as therapeutics	14
Xanthone-enriched fraction ofGarcinia mangostanaand α-mangostin improve the spatial learning and memory of chronic cerebral hypoperfusion rats	14
Research progress of pharmacological effects of Siraitia grosvenorii extract	14
Crude polysaccharide from the milky mushroom, Calocybe indica, modulates innate immunity of macrophage cells by triggering MyD88-dependent TLR4/NF-κB pathway	14
Release rate determination from in situ gel forming PLGA implant: a novel ‘shape-controlled basket in tube’ method	14
Black mulberry fruit extract alleviates streptozotocin-induced diabetic nephropathy in rats: targeting TNF-α inflammatory pathway	14
Pharmacokinetics and in vivo distribution of optimized PLGA nanoparticles for pulmonary delivery of levofloxacin	14
Retracted: Inhibiting the PI3K/Akt, NF-κB signalling pathways with syringic acid for attenuating the development of oral squamous cell carcinoma cells SCC131	14
Insulinotropic and antidiabetic properties of Eucalyptus citriodora leaves and isolation of bioactive phytomolecules	13
Atractylodin inhibited the migration and induced autophagy in cholangiocarcinoma cells via PI3K/AKT/mTOR and p38MAPK signalling pathways	13
Semi-solid extrusion 3D printing of starch-based soft dosage forms for the treatment of paediatric latent tuberculosis infection	13
Combining combretastatin A4 phosphate with ginsenoside Rd synergistically inhibited hepatocellular carcinoma by reducing HIF-1α via PI3K/AKT/mTOR signalling pathway	13
Gut microbiome-mediated modulation of hepatic cytochrome P450 and P-glycoprotein: impact of butyrate and fructo-oligosaccharide-inulin	13
Kaempferol ameliorates secretagogue-induced pseudo-allergic reactions via inhibiting intracellular calcium fluctuation	13
By reducing oxidative stress, naringenin mitigates hyperglycaemia-induced upregulation of hepatic nuclear factor erythroid 2-related factor 2 protein	13
Steroidal saponins from Trillium govanianum as α-amylase, α-glucosidase, and dipeptidyl peptidase IV inhibitory agents	13
Chrysophanol exerts neuroprotective effects via interfering with endoplasmic reticulum stress apoptotic pathways in cell and animal models of Alzheimer’s disease	13
Environmental toxicants, oxidative stress and health adversities: interventions of phytochemicals	13
Rosmarinic acid ameliorates septic-associated mortality and lung injury in mice via GRP78/IRE1α/JNK pathway	13
Isoliquiritigenin attenuates inflammation and modulates Nrf2/caspase-3 signalling in STZ-induced aortic injury	13
An in vitro study on the reversal of epithelial to mesenchymal transition by brusatol and its synergistic properties in triple-negative breast cancer cells	13
Jatrorrhizine: a review of its pharmacological effects	13
Improvement of the bioavailability of curcumin by a supersaturatable self nanoemulsifying drug delivery system with incorporation of a hydrophilic polymer: in vitro and in vivo character	13
Cissus quadrangularis extract attenuates diabetic nephropathy by altering SIRT1/DNMT1 axis	12
Sodium hydrogen sulfide upregulates cystathionine β-synthase and protects striatum against 3-nitropropionic acid-induced neurotoxicity in rats	12
Pyoluteorin induces cell cycle arrest and apoptosis in human triple-negative breast cancer cells MDA-MB-231	12
Functionalised molybdenum disulfide nanosheets for co-delivery of doxorubicin and siRNA for combined chemo/gene/photothermal therapy on multidrug-resistant cancer	12
Bile acid sequestrants: a review of mechanism and design	12

Ephedra sinica polysaccharide alleviates airway inflammations of mouse asthma-like induced by PM2.5 and ovalbumin via the regulation of gut microbiota and short chain fatty acid	12
Pharmacokinetics-based chronoefficacy of Fuzi against chronic kidney disease	12
Cordycepin induces M1/M2 macrophage polarization to attenuate the liver and lung damage and immunodeficiency in immature mice with sepsis via NF-κB/p65 inhibition	12
Shikonin ameliorates experimental autoimmune encephalomyelitis (EAE) via immunomodulatory, anti-apoptotic and antioxidative activity	12
Modulation of NF-κB and MAPK signalling pathways by hydrolysable tannin fraction from Terminalia chebula fruits contributes to its anti-inflammatory action in RAW 264.7 cells	12
Ganoderma lucidum ameliorates the diabetic nephropathy via down-regulatory effect on TGFβ-1 and TLR-4/NFκB signalling pathways	12
Circadian clock regulates hepatotoxicity of Tripterygium wilfordii through modulation of metabolism	11
Augmented cytotoxicity using the physical adsorption of Poloxamer 188 on allicin-loaded gelatin nanoparticles	11
Moringa oleifera: a systematic review of its botany, traditional uses, phytochemistry, pharmacology and toxicity	11
Near-infrared spectroscopy and HPLC combined with chemometrics for comprehensive evaluation of six organic acids in Ginkgo biloba leaf extract	11
Nanomedicine: a new paradigm to overcome drug incompatibilities	11
LncRNA Fendrr inhibits hypoxia/reoxygenation-induced cardiomyocyte apoptosis by downregulating p53 expression	11
Characterization of lignans in Forsythiae Fructus and their metabolites in rats by ultra-performance liquid chromatography coupled time-of-flight mass spectrometry	11
VX-765 ameliorates inflammation and extracellular matrix accumulation by inhibiting the NOX1/ROS/NF-κB pathway in diabetic nephropathy	11
Cilostazol attenuated prenatal valproic acid-induced behavioural and biochemical deficits in a rat model of autism spectrum disorder	11
Fructus arctii: an overview on its traditional uses, pharmacology and phytochemistry	11
Antiviral activity against Zika virus of a new formulation of curcumin in poly lactic-co-glycolic acid nanoparticles	11
Triterpenoid compound betulin attenuates allergic airway inflammation by modulating antioxidants, inflammatory cytokines and tissue transglutaminase in ovalbumin-induced asthma mice model	11
Berberine, a natural alkaloid sensitizes human hepatocarcinoma to ionizing radiation by blocking autophagy and cell cycle arrest resulting in senescence	11
Modulation of multiple cellular signalling pathways as targets for anti-inflammatory and anti-tumorigenesis action of Scopoletin	11
Alamandine protects against renal ischaemia–reperfusion injury in rats via inhibiting oxidative stress	11
A comprehensive review of therapeutic approaches available for the treatment of cholera	11
Studies on the compatibility mechanism and material basis of Danggui Buxue Decoction against anemia mice using metabonomics and network pharmacology	11
Precision dosing-based optimisation of paroxetine during pregnancy for poor and ultrarapid CYP2D6 metabolisers: a virtual clinical trial pharmacokinetics study	11
Vanillic acid–Zn(II) complex: a novel complex with antihyperglycaemic and anti-oxidative activity	10
Fluvastatin protects neuronal cells from hydrogen peroxide-induced toxicity with decreasing oxidative damage and increasing PI3K/Akt/mTOR signalling	10
Ameliorative effects of garlic oil on FNDC5 and irisin sensitivity in liver of streptozotocin-induced diabetic rats	10
Silencing of SNHG6 alleviates hypoxia/reoxygenation-induced cardiomyocyte apoptosis by modulating miR-135a-5p/HIF1AN to activate Shh/Gli1 signalling pathway	10
Investigation on the metabolic characteristics of isobavachin in Psoralea corylifolia L. (Bu-gu-zhi) and its potential inhibition against human cytochrome P450s and UDP-glucuronosyltransferases	10
Preparation of loratadine nanocrystal tablets to improve the solubility and dissolution for enhanced oral bioavailability	10
Neuroprotective effects of synthetic borneol and natural borneol based on the neurovascular unit against cerebral ischaemic injury	10
The traditional uses, phytochemistry, pharmacology and toxicology of Dictamnus dasycarpus: a review	10
Glucosamine attenuates drug resistance in Mitoxantrone-resistance breast cancer cells	10
Comparative bioavailability of curcuminoids from a water-dispersible high curcuminoid turmeric extract against a generic turmeric extract: a randomized, cross-over, comparative, pharmacokinetic study	10
Abrogation of STAT3 activation cascade by Ginkgolide C mitigates tumourigenesis in lung cancer preclinical model	10
Scrophularia ningpoensisHemsl: a review of its phytochemistry, pharmacology, quality control and pharmacokinetics	10
Improvement of the pharmacokinetic characteristics of liposomal doxorubicin using CD47 biomimickry	10
Therapeutic effects of açaí seed extract on hepatic steatosis in high-fat diet-induced obesity in male mice: a comparative effect with rosuvastatin	10
A honokiol-enriched Magnolia officinalis Rehder & E.H. Wilson. bark extract possesses anxiolytic-like activity with neuroprotective effect through the modulation of CB1 receptor	10
The hepatoprotective effect and mechanism of lotus leaf on liver injury induced by Genkwa Flos	9
A CGRP receptor antagonist peptide formulated for nasal administration to treat migraine	9
Dietary supplements and medicinal plants in urolithiasis: diet, prevention, and cure	9
Medicinal plants from the Himalayan region for potential novel antimicrobial and anti-inflammatory skin treatments	9
Caffeic acid regulates glucose homeostasis and inhibits purinergic and cholinergic activities while abating oxidative stress and dyslipidaemia in fructose-streptozotocin-induced diabetic rats	9
Umbelliferone ameliorates oxidative stress and testicular injury, improves steroidogenesis and upregulates peroxisome proliferator-activated receptor gamma in type 2 diabetic rats	9
A review of anti-tumour effects of ginsenoside in gastrointestinal cancer	9
Inhibition of p90 ribosomal S6 kinase potentiates cisplatin activity in A549 human lung adenocarcinoma cells	9
Mechanisms exploration of Xiaojin Pills on lung cancer based on metabolomics and network pharmacology	9
Carissa carandasL. – phyto-pharmacological review	9
3D Printing: an appealing technology for the manufacturing of solid oral dosage forms	9
Pharmacokinetic interaction between a Chinese herbal formula Huosu Yangwei oral liquid and apatinib in vitro and in vivo	9
Tropisetron improves pancreas function and increases insulin synthesis and secretion in the STZ-induced diabetic rats: involvement of UCP2/ZnT8 pathway	9
Metabolome modulatory effects of Kigelia africana (Lam.) Benth. fruit extracts on oxidative stress, hyperlipidaemic biomarkers in STZ-induced diabetic rats and antidiabetic effects in 3T3 L1 ad	9
A review on phytochemical and therapeutic potential ofIris germanica	9
Remifentanil protects heart from myocardial ischaemia/reperfusion (I/R) injury via miR-206-3p/TLR4/NF-κB signalling axis	9
Nrf2 signalling pathway and autophagy impact on the preventive effect of green tea extract against alcohol-induced liver injury	9
Phytochemicals in traditional Chinese medicine can treat gout by regulating intestinal flora through inactivating NLRP3 and inhibiting XOD activity	9
l-Borneol ameliorates cerebral ischaemia by downregulating the mitochondrial calcium uniporter-induced apoptosis cascade in pMCAO rats	9
Specnuezhenide reduces carbon tetrachloride-induced liver injury in mice through inhibition of oxidative stress and hepatocyte apoptosis	8
Metabolomics coupled with integrative pharmacology reveals the therapeutic effect of l-borneolum against cerebral ischaemia in rats	8
Long noncoding RNA HOXA-AS2 accelerates cervical cancer by the miR-509-3p/BTN3A1 axis	8
Zanthoxylum zanthoxyloides inhibits lipopolysaccharide- and synthetic hemozoin-induced neuroinflammation in BV-2 microglia: roles of NF-κB transcription factor and NLRP3 inflammasome activation	8
β-Caryophyllene attenuates lipopolysaccharide-induced acute lung injury via inhibition of the MAPK signalling pathway	8
Self-nanoemulsifying drug delivery system to improve transcorneal permeability of voriconazole: in-vivo studies	8
Serum metabolomics reveals the intervention mechanism and compatible regularity of Chaihu Shu Gan San on chronic unpredictable mild stress-induced depression rat model	8
Botany, traditional uses, phytochemistry and pharmacological activity of Crataegus pinnatifida (Chinese hawthorn): a review	8
PI3K/AKT/Nrf2 signalling pathway is involved in the ameliorative effects of xanthohumol on amyloid β-induced oxidative damage and bone loss	8
Protective effects of duloxetine against chronic immobilisation stress-induced anxiety, depression, cognitive impairment and neurodegeneration in mice	8
Interferon regulatory factor 6 correlates with the progression of non-small cell lung cancer and can be regulated by miR-320	8
Clock gene Bmal1 controls diurnal rhythms in expression and activity of intestinal carboxylesterase 1	8
Effect of Hibiscus sabdariffa and Zingiber officinale on pharmacokinetics and pharmacodynamics of amlodipine	8
Oral biopharmaceutics tools: recent progress from partnership through the Pharmaceutical Education and Research with Regulatory Links collaboration	8
The role of lncRNA ANRIL in the progression of hepatocellular carcinoma	8
A comparative study on pharmacokinetics and tissue distribution of 5-hydroxy-4-methoxycanthin-6-one and its metabolite in normal and dextran sodium sulfate-induced colitis rats by HPLC-MS/MS	7
Açaí berries (Euterpe oleracea Mart.) dried extract improves ethanol-induced ulcer in rats	7
β-Cyclodextrin-containing chitosan-oligonucleotide nanoparticles improve insulin bioactivity, gut cellular permeation and glucose consumption	7
Characterization of metabolic activity, isozyme contribution and species differences of bavachin, and identification of efflux transporters for bavachin-O-glucuronide in HeLa1A1 cells	7
Effect of genipin-1-β-d-gentiobioside on diabetic nephropathy in mice by activating AMP-activated protein kinase/silencing information regulator-related enzyme 1/ nuclear factor-κB pathway	7
Combination of urine and faeces metabolomics to reveal the intervention mechanism of Polygala tenuifolia compatibility with Magnolia officinalis on gastrointestinal motility disorders	7
The Protective Effect of Natural Compounds on Doxorubicin-Induced Cardiotoxicity via Nicotinamide Adenine Dinucleotide Phosphate Oxidase Inhibition	7

Performance and paroxetine stability in tablets manufactured by fused deposition modelling-based 3D printing	7
Repurposing of sildenafil as antitumour; induction of cyclic guanosine monophosphate/protein kinase G pathway, caspase-dependent apoptosis and pivotal reduction of Nuclear factor kappa light chain enh	7
Novel therapeutic approaches for Parkinson’s disease by targeting brain cholesterol homeostasis	7
Azilsartan ameliorates ventricular hypertrophy in rats suffering from pressure overload-induced cardiac hypertrophy by activating the Keap1–Nrf2 signalling pathway	7
Eugenol modulates insulin sensitivity by upregulating insulin receptor substrate-2 in non-alcoholic fatty liver disease in rats	7
Circ_UTRN ameliorates caerulein-induced acute pancreatitis in vitro via reducing inflammation and promoting apoptosis through miR-320-3p/PTK2 axis	7
Grape seed extract improved the fertility-enhancing effect of atorvastatin in high-fat diet-induced testicular injury in rats: involvement of antioxidant and anti-apoptotic effects	7
Evaluation of the effects of nanoparticles on the therapeutic function of platelet: a review	7
Anin vitroevaluation of antitumor activity of sirolimus-encapsulated liposomes in breast cancer cells	7
GenusBarleriaL. (Acanthaceae): a review of its taxonomy, cytogenetics, phytochemistry and pharmacological potential	7
Pharmacokinetic, bioavailability and tissue distribution study of astilbin in rats	7
Flavonoids as new regulators of mitochondrial potassium channels: contribution to cardioprotection	7
Natural substances derived from herbs or plants are promising sources of anticancer agents against colorectal cancer via triggering apoptosis	7