OOIR: Observatory of International Research

Papers

(The TQCC of Journal of Pharmacy and Pharmacology is 9. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-06-01 to 2026-06-01.)

Article	Citations
Tilianin obtained from Agastache mexicana inhibits monoamine oxidase and modifies depressive behavior in rats	84
Study on the targeted regulation of Scutellaria baicalensis leaf on glutamine–glutamate metabolism and glutathione synthesis in the liver of d-gal ageing rats	82
Photoactivation of pheophorbide-a utilizing 670 nm LEDs elicits cancer suppressive effects in androgen-independent prostate cancer cellular models	49
3-Demethyl-2-geranyl-4-prenylbellidifoline, a natural xanthone with diuretic and kidney protective properties	48
GL-V9 synergizes with oxaliplatin of colorectal cancer via Wee1 degradation mediated by HSP90 inhibition	47
A comprehensive review of traditional uses, phytochemistry and pharmacology of Reynoutria genus	39
Oleanolic acid ameliorates podocyte injury by increasing autophagy to attenuate diabetic nephropathy	37
Inhibition of human ether-à-go-go-related gene K+ currents expressed in HEK293 cells by three gingerol components from ginger	35
Exploring the potential of vaginal drug delivery: innovations, efficacy, and therapeutic prospects	35
Δ(9)-tetrahydrocannabinol protects cardiac tissue against endoplasmic reticulum and oxidative stresses, apoptosis, and inflammation in rats with hyperinsulinemia	35
Serum autotaxin level: a promising diagnostic biomarker in differentiating Graves’ disease and thyroiditis	31
Erythrocyte membrane-camouflaged mesoporous silica composite nanoparticles for loading and controlled release of the hepatoprotective agent silibinin: A-synthesis and physicochemical characterization	30
Eleutheroside E functions as anti-cervical cancer drug by inhibiting the phosphatidylinositol 3-kinase pathway and reprogramming the metabolic responses	29
Ginsenoside Rb1 ameliorates hippocampal neuroinflammation in rats after intracerebral hemorrhage by inactivating the TLR4/NF-kB pathway	28
PI3K/AKT/Nrf2 signalling pathway is involved in the ameliorative effects of xanthohumol on amyloid β-induced oxidative damage and bone loss	28
Ending nuclear weapons, before they end us	27
Rhamnetin: a review of its pharmacology and toxicity	26
Roles of pigment epithelium-derived factor in cardiomyocytes: implications for use as a cardioprotective therapeutic	26
Protective effect of Allium scorodoprasum L. ethanolic extract in cyclophosphamide-induced hepatotoxicity model in rats	26
Thyme extract could overcome diabetes-induced reproductive dysfunction by inhibiting oxidative damage and increasing the expression of insulin receptor substrate and pyruvate kinase in the rat sperm	26
Ling-Gui-Zhu-Gan decoction protects against doxorubicin-induced myocardial injury by downregulating ferroptosis	26
Preparation, characteristic, biological activities, and application of polysaccharide from Lilii Bulbus: a review	26
The therapeutic potential of curculigoside in poststroke depression: a focus on hippocampal neurogenesis and mitochondrial function	25
The pleiotropic effects of statins in rheumatoid arthritis	25
Wei-Tong-Xin exerts anti-inflammatory effects through TLR4-mediated macrophages M1/M2 polarization and affects GLP-1 secretion	24

Production of mRNA lipid nanoparticles using advanced crossflow micromixing	24
Evaluating the role of bromelain in diabetes management: a systematic review of research evidence and mechanisms of action	23
Phytochemical study and immunomodulatory activity of Fraxinus excelsior L.	22
LINC01572 promotes the malignant progression of lung adenocarcinoma by modulating p53 mediated by miRNA-338-5p/TTK axis	22
Validating the antidiabetic potential of Nakima (Tupistra clarkei Hook.f.), a traditional food from eastern Himalayan region, through network pharmacology and in vivo experimentation	22
Dexmedetomidine affects the NOX4/Nrf2 pathway to improve renal antioxidant capacity	21
Dendrophenol attenuates cardiac hypertrophy through inhibition of ferroptosis via the C-Jun/NCOA4 signaling pathway	21
N(Omega)-nitro-l-arginine methyl ester potentiates lidocaine analgesic and anaesthetic effect in rats	20
Therapeutically important bioactive compounds of the genus Polygonum L. and their possible interventions in clinical medicine	20
Cardioprotection of Eucommiae Folium: the extract and pharmaceutically active compounds attenuate hyperglycemia, mitochondrial dysfunction, calcium dyshomeostasis, insulin resistance, and oxidative st	20
Repurposing the familiar: Future treatment options against chronic kidney disease	20
Circular RNA hsa_circ_0026344 suppresses gastric cancer cell proliferation, migration and invasion via the miR-590-5p/PDCD4 axis	20
The effect of patient’s body weight, infusion connection point, and infusion pump position on intravenous multi-infusion drug delivery at low infusion rates suitable for premature neonates	20
Traditional uses, hepatoprotective potential, and phytopharmacology of Tinospora cordifolia: a narrative review	20
Three-dimensional printed personalized drug devices with anatomical fit: a review	19
Function and inhibition of Haspin kinase: targeting multiple cancer therapies by antimitosis	19
Correction to: FoxO1 as the critical target of puerarin to inhibit osteoclastogenesis and bone resorption	19
In vitro assessment of P-glycoprotein-mediated antiseizure medications efflux in a blood–brain barrier cell model	19
Scopoletin stimulates the secretion of insulin via a KATP channel-dependent pathway in INS-1 pancreatic β cells	19
Icariside II: natural occurrence, biotransformation, pharmacological activity, synthetic modification, pharmacokinetics, and bioavailability	19
Shaoyao Gancao decoction, an Ancient Classical Prescription: a review on its chemical composition, pharmacology, pharmacokinetics, clinical applications, and toxicology	18
Itrifal-e-Aftimoon potentiates imatinib-induced anti-leukemic effect by influencing FAK/STAT/Akt/ERK signalling pathways against chronic myeloid leukaemia in vitro	18
Therapeutic effects of Tanshinone IIA and Tetramethylpyrazine nanoemulsions on cognitive impairment and neuronal damage in Alzheimer’s disease rat models	18
Exploring the combined therapeutic efficacy of bexarotene and icariin in type 2 diabetic rats	17
Molecular mechanisms of endoplasmic reticulum stress-mediated acute kidney injury in juvenile rats and the protective role of mesencephalic astrocyte-derived neurotrophic factor	17
The potential applications of nanocomposites in 3D-printed drug delivery systems	17
Research progress on pharmacological effects of isoalantolactone	17
Investigation of the effect of Acai berry on the pharmacokinetics of Atorvastatin, Alogliptin and Empagliflozin: a herb–drug interaction study	17
Systems pharmacology-based drug discovery from Amaryllidaceae alkaloids and investigation of mechanisms of action in treatment of Alzheimer’s disease	16
Thymol suppressed tumor growth in vitro and in vivo through inducing calcium overload in colorectal cancer	16
Correction to: 1H-NMR-based metabolomics to dissect the traditional Chinese medicine promotes mesenchymal stem cell homing as intervention in liver fibrosis in mouse model of Wilson’s disease	16
Botany, traditional uses, phytochemistry, pharmacological and toxicological effects of Croton tiglium Linn.: a comprehensive review	16
Evaluation of methotrexate-loaded surfactants, ceramides and cholesterol-based lamellar phases as a topical treatment for psoriasis	16
The genus Oxytropis DC: application, phytochemistry, pharmacology, and toxicity	16
Ethnobotanical study of Zhuang medicinal herbs of Ardisia: variety systematization, traditional uses, phytochemistry, pharmacology, clinical application, and toxicity	15
Andrographolide attenuates oxidative stress and apoptosis in osteoporosis rats via MEK/ERK and Beclin-1/ATG-5-mediated autophagy pathway	15
Sanshimao formula inhibits the hypoxia-induced pro-angiogenesis of hepatocellular carcinoma cells partly through regulating MKK6/p38 signaling pathway	15
Characterizing resistance in prostate cancer at a single cell level with hormonal treatment and epigenetic inhibitors	15
Chrysin prevents inflammation-coinciding liver steatosis via AMPK signalling	15
Natural product mitigation of ferroptosis in platinum-based chemotherapy toxicity: targeting the underpinning oxidative signaling pathways	14
The combination of astragaloside IV and Panax notoginseng saponins attenuates cerebral ischaemia–reperfusion injury in rats through ferroptosis and inflammation inhibition via activating Nrf2	14
Gegen Qinlian Decoction protects kidney in diabetic rats by improving intestinal barrier and regulating intestinal microbiota	14
Nutritional benefits, ethnomedicinal uses, phytochemistry, pharmacological properties and toxicity of Spondias mombin Linn: a comprehensive review	14
Corrigendum to: The role of lncRNA ANRIL in the progression of hepatocellular carcinoma	14
Euterpe oleracea Mart. (Açai) seed extract improves physical performance in old rats by restoring vascular function and oxidative status and activating mitochondrial muscle biogenesis	14
Effects of dietary supplementation with arboreal medicinal mushrooms on stress coping strategies, depressive and anxiety-like behavior of rats	14
Research progress of pharmacological effects of Siraitia grosvenorii extract	14
Three-dimensional printed dosage forms based on disease-focussed perspectives	13
Ginkgo biloba extracts (GBE) protect human RPE cells from t-BHP-induced oxidative stress and necrosis by activating the Nrf2-mediated antioxidant defence	13
Psidium guajava leaves extract alters colonic microbiome composition and reduces intestinal sodium absorption in rats exposed to a high-sodium diet	13

Modulation of PPAR-γ/Nrf2 and AGE/RAGE signaling contributes to the chrysin cardioprotection against myocardial damage following ischemia/reperfusion in diabetic rats	13
Eplerenone reduces renal ischaemia/reperfusion injury by modulating Klotho, NF-κB and SIRT1/SIRT3/PGC-1α signalling pathways	13
A comprehensive review of scientifically reported phytochemicals to manage allodynia in chronic diabetes complications	13
Azithromycin concentration in rabbits’ plasma and posterior segment of the eyes following oral drug administration: a dose-finding study for the application in ocular toxoplasmosis	13
Genus Lupinus (Fabaceae): a review of ethnobotanical, phytochemical and biological studies	13
Mechanistic insights of methylcinnamate in improving oxidative stress and inflammation in acetaminophen-induced hepatotoxic mice by upregulating Nrf2 pathway	13
Brusatol’s anticancer activity and its molecular mechanism: a research update	13
Geraniol suppresses tumour growth and enhances chemosensitivity of 5-fluorouracil on breast carcinoma in mice: involvement of miR-21/PTEN signalling	13
Role of the integrin-linked kinase/TGF-β/SMAD pathway in sitagliptin-mediated cardioprotective effects in a rat model of diabetic cardiomyopathy	13
Use of kersetin and fisetin flavonoids in combination with pregabalin and gabapentin in the treatment of neuropathic pain	13
Genipin improves obesity through promoting bile secretion and changing bile acids composition in diet-induced obese rats	13
Ginkgo biloba extracts protect human retinal Müller glial cells from t-BHP induced oxidative damage by activating the AMPK-Nrf2-NQO-1 axis	13
Targeting together cholinesterases and serotonin reuptake against Alzheimer’s disease	13
Corrigendum to: Remimazolam alleviates neuropathic pain via regulating bradykinin receptor B1 and autophagy	13
Potential interactions between triazole antifungal agents and lorlatinib based on ultra-performance liquid chromatography-tandem mass spectrometry in rat plasma	12
Dietary supplements and medicinal plants in urolithiasis: diet, prevention, and cure	12
Gap junction is essential for the antidepressant effects of fluoxetine	12
Research progress on the pharmacy of tetramethylpyrazine and its pharmacological activity in cardiovascular and cerebrovascular diseases	12
Different protective capability of chlorogenic acid and quercetin against indomethacin-induced gastrointestinal ulceration	12
Combination of metabolomics and network pharmacology analysis to decipher the mechanisms of total flavonoids of Litchi seed against prostate cancer	12
Schisandrin B ameliorates adjuvant-induced arthritis in rats via modulation of inflammatory mediators, oxidative stress, and HIF-1α/VEGF pathway	12
Dendrobium officinale Kimura et Migo: traditional uses, agricultural technology, processing, chemical composition, pharmacological mechanisms, toxicology, and applications	12
Development and in vitro evaluation of solution-based pressurized metered-dose inhaler formulations using green propellants	12
Development of benznidazole orally disintegrating tablets for paediatric patients	12
Patchouli alcohol against renal fibrosis of spontaneously hypertensive rats via Ras/Raf-1/ERK1/2 signalling pathway	11
Correction to: Curcumin solid dispersion-loaded in situ hydrogels for local treatment of injured vaginal bacterial infection and improvement of vaginal wound healing	11
Inhaled exogenous thymosin beta 4 suppresses bleomycin-induced pulmonary fibrosis in mice via TGF-β1 signalling pathway	11
Menthol-based self microemulsifying drug delivery system for augmented intestinal absorption of edoxaban	11
Effect of carvedilol on pharmacokinetics of sofosbuvir and its metabolite GS-331007: role of P-glycoprotein	11
Development and characterization of natural phenolics-rich extracts and formulations based on Putoria calabrica leaf for wound healing applications	11
Ginsenoside Rg3 inhibits renal cell carcinoma cell migration, invasion, colony formation, and tube formation and enhances apoptosis through promoting the DNA demethylation and histone acetylation	11
Ambroxol mitigates renal ischemia/reperfusion-induced cardiac and renal injury via Nrf2/HO-1 activation and TLR4 pathway inhibition	11
Shaoyao Gancao Decoction protects against dextran sulfate sodium-induced ulcerative colitis by down-regulating ferroptosis	11
Wedelolactone suppresses breast cancer growth and metastasis via regulating TGF-β1/Smad signaling pathway	10
Risk stratification of AUC upward deviation in patients with low serum creatinine levels treated with vancomycin: a multicenter retrospective study	10
Berberine suppresses the migration and invasion of colon cancer cells by inhibition of lipogenesis through modulation of promyelocytic leukemia zinc finger-mediated sterol-regulatory element binding p	10
Phoenixin 14 ameloriates pancreatic injury in streptozotocin-induced diabetic rats by alleviating oxidative burden	10
Propolis prevents vascular endothelial dysfunction by attenuating inflammation and oxidative damage in the chronic unpredictable stress model of depression in rats	10
Novel peptide calcitonin gene-related peptide antagonists for migraine therapy	10
Corrigendum to: An injectable liposome for sustained release of icariin to the treatment of acute blunt muscle injury	9
Advances in inhaler therapy for asthma and chronic obstructive pulmonary disease: a comprehensive review of Fostair™ and Trimbow™	9
Effect of madecassoside in reducing oxidative stress and blood glucose in streptozotocin–nicotinamide-induced diabetes in rats	9
Alleviating vascular calcification with Bushen Huoxue formula in rats with chronic kidney disease by inhibiting the PTEN/PI3K/AKT signaling pathway through exosomal microRNA-32	9
3D DLP-printed cannabinoid microneedles patch and its pharmacokinetic evaluation in rats	9
Kaempferitrin, a major compound from ethanol extract of Chenopodium ambrosioides, exerts antitumour and hepatoprotective effects in the mice model of human liver cancer xenografts	9
Isolation, phytochemistry, characterization, biological activity, and application of Morinda officinalis How oligosaccharide: a review	9
The state and trends of cinnamaldehyde research over the past three decades: a bibliometric and visualized analysis	9
Monotropein alleviates sepsis-elicited acute lung injury via the NF-κB pathway	9
Potential of syringol and guaiacol in mitigating hyperglycemia associated dicarbonyl stress in rats subjected to high-fat high-fructose diet	9
Styrax (Liquidambar orientalis Mill.) promotes mitochondrial function and reduces cardiac damage following myocardial ischemic injury: the role of the AMPK-PGC1α signaling pathway	9
Research progress on ethnobotany, phytochemistry, pharmacological action, and applications of Engelhardia roxburghiana Wall: a review	9
Indolocarbazole alkaloid Loonamycin A inhibits triple-negative breast cancer cell stemness and Notch signalling	9
PD15, a steroidal saponin, induces apoptosis of HCT116 colorectal cancer cells via suppressing the Akt/GSK3β pathway	9
Pharmacological properties and derivatives of saikosaponins—a review of recent studies	9
Development and characterization of quetiapine-loaded microneedles-based transdermal patches for improved drug delivery	9
Homoplantaginin attenuates high glucose-induced vascular endothelial dysfunction via inhibiting store-operated calcium entry channel and endoplasmic reticulum stress	9
Botany, traditional uses, phytochemistry and pharmacological activity of Crataegus pinnatifida (Chinese hawthorn): a review	9
Imperatorin derivative OW1, a new vasoactive compound, attenuates cell proliferation and migration by inhibiting Nox1-mediated oxidative stress	9