Journal of Pharmacology and Experimental Therapeutics

Article	Citations
Contents	203
In Silico Simulations of Physicochemical and ADMET Properties of Curcumin Glucoside Derivatives (Abstract ID: 161637)	69
Chronic Opioid Use Leads to Exacerbated Hypersensitivity and Transcriptomic Changes in a Post-Operative Pain Model (Abstract ID: 165327)	46
Thermogenic Modulation Reduces Adipose Tissue Inflammation and Complications of Early Metabolic Dysfunction: Impact on Mitochondrial Proteomics and Adipose Lipidomics (Abstract ID: 159767)	43
Metabotropic Glutamate Receptor 1 (mGlu1) Positive Allosteric Modulators Exhibit Differential Effects at the mGlu1/5 Heterodimer (Abstract ID: 162597)	42
DNAJC13 Regulates GPCR Sorting at Endosomes (Abstract ID: 161875)	41
Development and Validation of Cell-Based Hydrogen Peroxide-Induced Senescence Model of Liver Fibrosis: HepG2 /Huh-7 and LX2 3D Spheroid (Abstract ID: 169675)	37
Dual Targeting of PI3K/mTOR Oncogenic Pathway Is a Promising Therapeutic Strategy for High-Risk Neuroblastoma (Abstract ID: 170196)	33
Orexin in the Dorsal Periaqueductal Gray Matter Fails to Modulate Anxiety- and Panic-like Behaviors in a Dangerous Environment (Abstract ID: 191219)	32
Enhancing the Scalability and Therapeutic Window of Taccalonolide-based Chemotherapeutics for the Treatment of Triple-negative Breast Cancers	30
Acute and Subchronic GPR171 Agonism Affects Anxiety and Depression in Female Mice	30
Development and Characterization of a Cytochrome P450 CYP3A7 Fetal Hepatocyte-Like Cell Model Derived from Induced Pluripotent Stem Cells	27
GPR55 Antagonist KLS-13019 Prevents and Reverses Chemotherapy-Induced Peripheral Neuropathy (CIPN) in Rats	27
Inhibiting the Cytotoxic Effect of Tubulin Polymerization-Promoting Protein (TPPP/p25α) Induced α-synuclein Aggregates Via 20S Proteasome Enhancement	27
Translational Pharmacokinetic/Pharmacodynamic Modeling of Targeted mRNA-LNP Therapeutics	25
Changes of ACE-2 related-miR-200b-3p expression over time are a predictive factor of long hospitalization for COVID-19: in silico, machine learning and validation analysis	24
Cholesterol Enrichment Alters Compartmentalization of G-Proteins Into Lipid Raft Microdomains	23
Calcium Channel Blockers as Novel Therapeutic Agents for Triple-Negative Breast Cancer	23
Sex Differences in the Behavioral and Metabolic Effects of Prenatal Stress in Early but not Late Adulthood in Mice	22
β-adrenoceptor-mediated vasodilation is enhanced by acute colchicine-treatment in men with essential hypertension	22
The Modulatory Effects of Citrus Flavonoid Hesperetin on Nrf2 Expression and NF-kB Signaling Pathway in LPS-Activated BV-2 Microglial Cells	22
Mechanistic Insights into Xanthohumol-Induced Apoptosis and Cytokine Modulation in Multiple Myeloma with a Focus on Nanoparticle Targeting Strategies	22
Molecular Dynamics Studies for Nirmatrelvir and the Main Protease from Variants of the Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2)	21
Podocyte injury triggers the formation of intercellular bridges	21
Editorial Board	21

Neurostimulation of the renal nerves as a novel therapeutic option for obstructive sleep apnea treatment	21
Table of Contents	20
Response to Comments on “Ocular Pharmacokinetics of Brimonidine Drug Delivery System in Monkeys and Translational Modeling for Selection of Dose and Frequency in Clinical Trials”	20
Editorial Board	20
Sigma Ligand-mediated Cytosolic Calcium Modulation in BV2 Microglia Cells	19
Regulated Trafficking of GABA Transporters, GAT1 and GAT3, in Response to Methamphetamine	19
Role of cyclophilin A overexpression in angiotensin II/mechanical stretch-induced vascular remodeling: Protective effect of adiponectin	19
Behavioral effects of fentanyl in presence or absence of chronic neuropathic pain in male and female rats	19
Fatty Acid Metabolizing Cytochrome P450 4F11 as a Novel Drug Target for Lung Cancer Treatment	19
A novel UVA-labile β-adrenergic agonist allows for optical control of subcellular signaling	19
Evidence for cytoprotective autophagy in response to HER2-targeted monoclonal antibodies	18
The Nrf2 activator tBHQ promotes OVA-Elicited Food Allergy in Mice	18
Beneficial Effects of the Direct AMP-Kinase Activator PXL770 in In Vitro and In Vivo Models of X-Linked Adrenoleukodystrophy	18
Recent Developments in On-Demand Voiding Therapies	17
Quantitative Systems Pharmacology and Machine Learning: A Match Made in Heaven or Hell?	17
5-Aza-4′-thio-2′-deoxycytidine, a New Orally Bioavailable Nontoxic “Best-in-Class”: DNA Methyltransferase 1–Depleting Agent in Clinical Development	17
Managing Iron Overload: A Gut Check	17
Special section on Breaking Barriers in Women's Cancer Treatment: Innovative Approaches and Experimental Therapeutics—Editorial	17
The Effects of the Dopamine Transporter Ligands JJC8-088 and JJC8-091 on Cocaine versus Food Choice in Rhesus Monkeys	16
Molecular Characterization and Bio-Fabrication of Bioactive Metabolites Derived from Thermotolerant Brucella Intermedia-DAZD and Its Antimicrobial Potentials (Abstract ID: 169939)	16
Hormonal Regulation of Cannabinoid-Induced Antinociception (Abstract ID: 192216)	16
Examining the Nephrotoxicity Induced by Benzalkonium Chlorides in 2D and 3D-Cultured Human Proximal Tubule Epithelial Cells (Abstract ID: 161924)	16
Pharmacological Characterization of a-Ethyltryptamine-based 5-HT2A Receptor Agonists for Therapeutic Use (Abstract ID: 190197)	16
Amlodipine use in Mild Cognitive Impairment reduces the risk of incident dementia in National Alzheimer’s Coordinating Center participants aged ≥55 years from 2014-2019	15
Effects of hsa-miR-9-3p and hsa-miR-9-5p on Topoisomerase II β Expression in Human Leukemia K562 Cells with Acquired Resistance to Etoposide	15
An Integrative Approach to Elucidate Mechanisms Underlying the Pharmacokinetic Goldenseal-Midazolam Interaction: Application of In Vitro Assays and Physiologically Based Pharmacokinetic Models to Unde	15
Neurosteroid mitigation of developmental neurological dysfunction, long-term epileptic biomarkers, chronic neuroinflammation, and neurodegeneration in a pediatric rat model of organophosphate exposure	15
Compounds with dual glutaminase inhibition and Nrf2 activation activities enhance morphine analgesia and reduce pain sensitization in chemotherapy-induced peripheral neuropathy mouse model	15
Antithrombotic potential of lornoxicam and possible mechanistic pathways	15
Rapid Characterization of the Functional and Pharmacological Consequences of Cantú Syndrome KATP Channel Mutations in Intact Cells	15
Correction to “Protective Effect of Anwulignan on Gastric Injury Induced by Indomethacin in Mice”	14
Effects of Volatile Anesthetics versus Ketamine on Blood-Brain Barrier Permeability via Lipid-Mediated Alterations of Endothelial Cell Membranes	14
Correction to “Central Nervous System Distribution of an Opioid Agonist Combination with Synergistic Activity”	14
Discriminative Stimulus Effects of Ethanol, Alprazolam and Pentobarbital in Rats	14
Spinal Aha1 inhibition improves morphine therapy for pain management	14
Quantitative phosphoproteomic analysis defines distinct cAMP signaling networks emanating from AC2 and AC6 in human airway smooth muscle cells	14
Effects of Dopamine D1-Like Receptor Ligands on Food-Cocaine Choice in Socially Housed Male Cynomolgus Monkeys	14
Mechanism of fructo-oligosaccharides on potentiating GLP-1 release from enteroendocrine cells	14
Pharmacological and Genetic Preclinical Models of Ghrelin Receptor Functional Selectivity to Investigate Metabolic Disease Pathophysiology	14
The Effects of Taurine on Alcohol-Associated Liver Disease are Dose-Dependent Associated with Alterations of Taurine-Conjugated Bile Acids and FXR-FGF15 Signaling	14
Biodistribution of Agmatine to Brain and Spinal Cord after Systemic Delivery	14
Antinociceptive and Discriminative Stimulus Effects of Six Novel Psychoactive Opioid Substances in Male Rats	14
Response to Comments on “Increasing Enzyme Mannose-6-Phosphate Levels but Not Miglustat Coadministration Enhances the Efficacy of Enzyme Replacement Therapy in Pompe Mice”	14
Enhancement of Muscarinic Receptor-Induced Contractions by Hydrogen Sulfide-Releasing Compounds in Bovine Isolated Irides	14
Toxicology testing in minipigs of a heroin vaccine intended for clinical treatment of opioid use disorder	13
The neuropeptide receptor GPR83 regulates anxiety-like behavior	13
Intracellular metabotropic glutamate receptor 5 (mGlu5) triggers ER calcium release distinct from cell surface counterparts in striatal neurons	13
Editorial Board	13
Preclinical Pharmacokinetic and Pharmacodynamic Evaluation of Intradermal Growth hormone and Insulin Delivery using Novel Microneedles in Guinea pigs and Rats	13
Dissecting the novel anti-obesity mechanism of prostaglandin D2 via DP1 receptor agonism utilizing mouse 3T3-L1 adipocytes as well as primary human subcutaneous adipocytes	13

Multiomics approach to interrogate translational regulation to GPCR signaling and its spatial bias	13
No Evidence for Beneficial Empagliflozin Effects in the Kidney of Female Rats in a Streptozotocin-induced Model of Type 1 Diabetes	13
Proximity Labeling Reveals a Multivalent Scaffold that Targets GRK5 to a Signaling Complex with Beta-Adrenergic Receptors	13
Nanoencapsulation of Curcumin-Piperine Complex for Targeting CYP17A1 in Castration-Resistant Prostate Cancer	13
Roles of Hepatic Bile Acid Transporters in Hepatocellular Carcinoma	12
A Glutamate N-Methyl-d-Aspartate (NMDA) Receptor Subunit 2B–Selective Inhibitor of NMDA Receptor Function with Enhanced Potency at Acidic pH and Oral Bioavailability for Clinical Use	12
Analgesic and Side Effect Profiles of Novel Alpha-2 Adrenergic Receptor Agonists	12
A Novel Charged Sodium-Channel Blocker, Ntx-1175, Is Effective In Reducing Acute Visceral Hypersensitivity In Vivo	12
Breaking free from opioids: A turning point in acute pain management	12
Overcoming Cetuximab Resistance in Colorectal Cancer through Inhibition of HGF Processing	12
Monensin and its derivatives increase MHC Class I and II presentations in breast cancer	12
MAL-PD Theory/Algorithm Guided Clinical Protocol Design for Computerized Data Analysis and Digital Conclusions in Drug Evaluations for Single Drugs and Combinations	12
A “Furious” Effort to Develop Novel 3,4-Methylenedioxymethamphetamine-Like Therapeutics	12
Pharmacological and toxicological profiling of JAMC-4/108: targeted induction of apoptosis in human colorectal cancer cells	12
Using a Clinical Pharmacology Elective to vertically Integrate Basic Pharmacology Content Beyond the Pre-clerkship Phase	12
Targeting HDAC6 in the Dorsal Root Ganglia for the Management of Mechanical Allodynia in Models of Peripheral Nerve Injury	12
Bioinformatic Determination of Potential Protein Targets of Metformin Activity in Hyperlipidemia	12
Protective effect of 2-hydroxyestrone and 2-hydroxyestradiol against chemically induced hepatotoxicity in vitro and in vivo	12
Novel Catalytic Antioxidant Formulation Decreases Oxidative Stress, Neuroinflammation and Cognitive Dysfunction in a Model of Nerve Agent Intoxication	12
Multi-Omics and Electrophysiological Examination of GABAA Receptors in the Dorsolateral Prefrontal Cortex of Humans with Alcohol Use Disorder (Abstract ID: 189092)	11
Discovery of a Potent and CNS-penetrable Anti-mitotic Agent That Shows Efficacy against Tumor Growth and Metastasis (Abstract ID: 189061)	11
Respective Roles of CYP4F2 and CYP2D6 in the Formation of Even- and Odd-Carbon Carboxylic Acid Metabolites of Benzalkonium Chloride in Human Hepatocytes (Abstract ID: 170055)	11
Formulation, Characterization and Pharmacokinetic Study of a Novel Lipid Nanoparticle Formulation of Bisphosphonate Conjugated Angiotensin 1-7 (Abstract ID: 190780)	11
Pharmacokinetics and Safety of the Lysine Specific Histone Demethylse-1 Inhibitor Seclidemstat in Cats with Oral Squamous Cell Carcinoma (Abstract ID: 166436)	11
In-Silico Discovery of CIP2A Inhibitors for Alzheimer's Disease Therapy (Abstract ID: 164859)	11
Discovery and Structure-activity Relationship of Synthetic Cathinone-Derived Acetylcholine M2 Receptor Antagonists (Abstract ID: 162036)	11
CCK-58 and CCK-8 Are Non-Equivalent in Signal Transduction at Human Cholecystokinin 1 Receptor (CCK1R) in Transfected Cell Lines (Abstract ID: 188910)	11
Selective Deletion of β2-Aderergic Receptor in Myeloid Cells Improve Cardiac Function After Myocardial Infarction via Annexin A1 (Abstract ID: 165406)	11
Amlodipine Protects Against the Bruton's Tyrosine Kinase (BTK) Inhibitor, Acalabrutinib-Induced Endothelial Dysfunction (Abstract ID: 171265)	11
Analgesic Properties of the Natural Product Barettin Are Mediated by the 5HT2A/C Receptors (Abstract ID: 165920)	11
Enantioselective Metabolism of Arachidonic Acid by Human Cytochrome P450s Using LC-MS/MS (Abstract ID: 189543)	11
A Novel Sulindac Derivative Protects against Oxidative Damage by a Cyclooxygenase-Independent Mechanism	11
The ß2-AR agonist Formoterol Restores Hallmark Features of Adrenal Cushing's Syndrome (Abstract ID: 160243)	11
A Massively Parallel Reporter Assay Library to Screen Short Synthetic Promoters in Mammalian Cells (Abstract ID: 159301)	10
Pharmacological Modulation of Muscarinic M4 Receptors Reduces Striatal Spontaneous Acetylcholine Release with Little to No Effect on Dopamine In Vivo (Abstract ID: 167167)	10
Identification of Infigratinib as a Potent Reversible Inhibitor and Mechanism-Based Inactivator of CYP2J2: Nascent Evidence for a Potential In Vivo Metabolic Drug-Drug Interaction with Rivaroxaban	10
Therapeutic Effects of Time-Limited Treatment with Brivaracetam on Posttraumatic Epilepsy after Fluid Percussion Injury in the Rat	10
Using a rich-lean transition procedure to evaluate putative antianxiety medications	10
Target Cell Activation of a Structurally Novel NOD-Like Receptor Pyrin Domain-Containing Protein 3 Inhibitor NT-0796 Enhances Potency	10
Angiotensin-(1-7) or Alamandine Modulates Bioenergetics in the Human Brain Microvascular Endothelial Cells Aging In Vitro (Abstract ID: 161351)	10
L-Lactate Binding to Hydroxycarboxylic Acid Receptor 1 (HCAR1) Mediates Cell Signaling and Promotes Brain-Derived Neurotrophic Factor Expression in Mammalian Astrocytes (Abstract ID: 168203)	10
Central Nervous System Delivery of the Catalytic Subunit of DNA-Dependent Protein Kinase Inhibitor Peposertib as Radiosensitizer for Brain Metastases	10
A novel loncastuximab-based cucurmosin immunotoxin with high potency in vitro against lymphoma	10
Corrigendum to “Recent Developments in On-Demand Voiding Therapies” [The Journal of Pharmacology and Experimental Therapeutics 390 (2024) 302-317]	10
Neuroprotection in C. Elegans Models of Parkinson's Disease: Discovering Therapeutics Via Small Molecule High Throughput Screening and RNA Interference (Abstract ID: 160193)	10
Comments on “Ocular Pharmacokinetics of Brimonidine Drug Delivery System in Monkeys and Translational Modeling for Selection of Dose and Frequency in Clinical Trials”	10
Evaluating the Impact of a Low Dose of LSD on EEG Spectral Signature in Participants with Depressed Mood (Abstract ID: 163720)	10
Sinomenine alleviates cancer-induced bone pain by promoting p65 ubiquitination and modulating microglial polarization	10
How Do Stress, Salt, and Sex Interact to Affect Rat Proactive Avoidance Learning and Retention, and What Implications Do These Interactions Have for Hypertension? (Abstract ID: 161169)	10
SAR Investigation of GPR183 Antagonists for the Treatment of Neuropathic Pain (Abstract ID: 159317)	9
Comparison of the Genomic Activity of an EP4-Receptor and β2-Adrenoceptor Agonist in BEAS-2B Human Bronchial Epithelial Cells: In Search of Compartmentalized, cAMP-Dependent Gene Expression	9
Chronic Exposure to Organophosphate Pesticides and Elevated Markers of Systemic Inflammation: Possible Neuroinflammatory and Genotoxic Effects	9
Editorial Board	9
Investigation of the Pharmacokinetics and Anticonvulsant Effect of Selected Oxazolidinone Derivatives in Rats (Abstract ID: 157153)	9
The Protective Effect of Panduratin A on Renal Fibrosis in Human Renal Proximal Tubular Cells and Unilateral Ureteral Obstruction Mice (Abstract ID: 160875)	9
Impact of SLC43A3/ENBT1 Expression and Function on 6-Mercaptopurine Transport and Cytotoxicity in Human Acute Lymphoblastic Leukemia Cells	9
Cover	9
Ellagic Acid (EA) Promotes Osteoblastic Differentiation of Dental Pulp-Derived Stem Cells (DPSCs) by Upregulating KLF2 and by Inducing Autophagy/Mitophagy	9
Combination of Epigallocatechin 3 Gallate and Ellagic Acid Improves Memory Impairment in a Triple-Transgenic Mouse Model of Alzheimer's Disease (Abstract ID: 170147)	9
The Contribution of Allosteric Interactions to the Long-Lasting Effects of MCAM in Rats (Abstract ID: 157620)	9
Polypharmacology as a New Drug Design Approach for Treating Chronic Pain (Abstract ID: 157379)	9
Protective Functions of Metformin in LPS-induced H9C2 Injury by miR-497-5p/BTRC/IκBα axis-mediated NF-κB pathway activation	9
Evaluation of systemic and brain pharmacokinetic parameters for repurposing metformin using intravenous bolus administration	9
Targeting Epigenetic and Oncogenic Signaling in Medulloblastoma: Comparative Analysis of HDAC/PI3K Dual Targeting and HDAC Inhibition (Abstract ID: 159719)	9
COL4A1 Exacerbates Ischemic Stroke-Induced Neuronal Apoptosis via Lactate-Depend Lysine Lactylation (Abstract ID: 160754)	9
Longitudinal Impact of Mnemonics Use on Pharmacy Students’ Exam Performance and Perceptions of Knowledge Retention and Clinical Application	8
Contents	8
Ovariectomy Promotes Angiotensin II-induced Renal Dysfunction and Vasopressin Excretion via 12/15-Lipoxygenase	8
Sex Differences in GABA Regulation of Dopamine Release in the Nucleus Accumbens and its Role in Cocaine Use Disorder	8
Intestinal Dysbiosis Alters Seizure Burden and Antiseizure Medicine Activity Profile in the Theiler’s Virus Model of Acute Encephalitis	8
Metformin as a Potential Countermeasure for the Central Nervous System Effects of Radiation Exposure	8
Potential Additive Effects of Ethanol and Methamphetamine Self-Administration in Rats (Abstract ID: 158460)	8
Associations Between Proinflammatory Cytokines, Laboratory-evoked Pain, and Opioid Response Profiles in Healthy Human Subjects	8
Renal Cytotoxicity of the E-Vaping Flavoring Agent Menthol	8
Elucidating the Drug-Drug Interaction Potential of Hydroxychloroquine Metabolites due to Direct and Time-Dependent Inhibition of CYP3A	8
Identifying Selective Substrates and/or Inhibitors of Renal Drug Uptake Transporters	8
The Role of Gender Pharmacogenetics in the Personalization of Drug Treatment	8
GPR55 Antagonist KLS-13019 Reverses Chemotherapy-Induced Peripheral Neuropathy (CIPN) in Rats	8
The Effect of Adolescent Fluoxetine on Neurogenesis and Stress Susceptibility in Adult Mice (Abstract ID: 168215)	8
Comparison of Δ9-tetrahydrocannabinolic acid A (THCA-A) and Delta-9-tetrahydrocannabinol (THC) in neuronal cell functions	8

Lung Injury in Mice from Acute Cutaneous Exposure to Vesicating Agent Nitrogen Mustard	8
Inhibition of Nociception Produced by Structurally Distinct Inhibitors of Fatty Acid Amide Hydrolase and Soluble Epoxide Hydrolase (Abstract ID: 189568)	7
Generation and Characterization of a Serum Albumin-Humanized Mouse Model For Biomarker Discovery	7
Efficacy of LSD1 Directed Agents is Enhanced with Kinase Signaling Inhibition in Glioblastoma Stem Cells	7
EEG studies reveal estradiol-dependent differences in GluN2A-containing NMDAR function	7
EAATs for stroke: to modulate or not to modulate	7
Neuroprotection in C. Elegans Parkinson’s Disease Models: Discovering Therapeutic Insights via RNAi and Small Molecule High Throughput Screening	7
Activation of CYP3A Enzymes in the Human Liver by Chronic Alcohol Exposure and Its Association with the Functional Effects of CYP3A-CYP2E1 Interactions (Abstract ID: 163729)	7
Impact of Posttranscriptional Modifications in Novel Bioengineered RNAs (Abstract ID: 163872)	7
DBeQ derivative targets vacuolar protein sorting 4 functions in cancer cells and suppresses tumor growth in mice	7
Xylazine-Induced Tolerance and Interactions with Fentanyl (Abstract ID: 191759)	7
Human Neuromuscular Junction Platform for Investigating Pathogen and Toxin-Induced Dysfunction in Disease and Drug Discovery (Abstract ID: 191678)	7
The Effect of Acute and Chronic Administration of Fluoxetine on R−(−)− DOI Induced Head Twitch Response in Swiss-Webster Mice	7
Assessment of Dextromethorphan on Compulsive Behavior Using the Schedule-Induced Polydipsia Paradigm in Rats	7
A2B adenosine receptor-mediated intracellular calcium mobilization: Involvement of Gi, Gq, Gs, β-arrestins, and protein kinase C	7
Neuroimmune Circuitry of Midbrain Dopamine Neurons	7
Table of Contents	7
Deciphering immunological mechanisms underlying the efficacy of nanoparticle-based vaccines and novel adjuvants against Opioid Use Disorder (OUD)	7
Antiproliferative effects of dihydrotanshinone I on autosomal dominant polycystic kidney disease via immunomodulation	7
Crosstalk between inflammation, voiding dysfunction, and psychiatric symptoms: novel hypothesis and therapeutics for urinary incontinence	7
Cannabidiol interactions with Δ-9-tetrahydrocannabinol on antinociception after carrageenan-induced inflammatory pain in male and female rats	7
Proximity Labeling Uncovers a Novel Putative Role for Spinophilin as a Mediator of Dendritic Protein Homeostasis (Abstract ID: 191477)	7
NOSH-aspirin (NBS-1120) inhibits estrogen receptor–negative breast cancer in vitro and in vivo by modulating redox-sensitive signaling pathways	7
High brain-blood barrier permeability highlights a new class of neurolysin activators as promising candidates for stroke treatment: a pilot pharmacokinetic study in mice	7
Characterizing the Role of Ser670 Phosphorylation in Non-canonical Mechanisms of GRK2 Inhibition in Heart Failure	7
Dynorphin release in the dorsal nucleus accumbens drives decreased feeding and consummatory reward behavior in mice	7
Regulation of Neuronal Activity by GluD1 Current in Brain Slices	7
Renin-Angiotensin System Components and Arachidonic Acid Metabolites as Biomarkers of COVID-19	7
TLR4 downregulation protects against cisplatin-induced ototoxicity in adult and pediatric patients with cancer	7
Combined stress and alcohol exposure: Synergistic effects on alcohol-seeking behaviors and neuroinflammation	7
Chemotherapeutics-Loaded Poly(Dopamine) Core-Shell Nanoparticles for Breast Cancer Treatment	7
8-Aminoinosine and 8-Aminohypoxanthine Inhibit Purine Nucleoside Phosphorylase and Exert Diuretic and Natriuretic Activity	7
Population Pharmacokinetic/Pharmacodynamic Modeling and Simulation of a Flat Quarterly Riliprubart Dosing Regimen for Patients With Cold Agglutinin Disease	6
The BioGuard Framework: Setting New Standards for Digital Biomarker Use in Clinical Trials	6
Editorial Board	6
Rapid-Onset, Short-Duration Induction of Colorectal Contractions in Anesthetized, Adult, Male Rats	6
Spinal Hsp90 Inhibition Augments Opioid-Induced Antinociception via Upregulation of GAT-2 Expression and GABA Reuptake (Abstract ID: 164345)	6
Methamphetamine Dysregulation of the Central Nervous System and Peripheral Immunity	6
Our Approach to Updating the Cardio System Pharmacology Knowledge Objectives	6
Biomolecular condensates defined by Activator of G protein Signaling 3 exhibit distinct properties and regulation	6
12-(S)-Hydroxyeicosatetraenoic Acid and GPR31 Signaling in Spinal Cord in Neuropathic Pain	6
In Vitro 2,3- and 3,4-Dibromophenol Nephrotoxicity in Isolated Kidney Cells	6
Pharmacology Retention and Evolving Memory Palaces: How the Method of Loci can be Modified for Medical Students’ Pharmacology Learning	6
Dopamine may increase Akt through D1-like receptor activation of PI3 Kinase in Macrophages	6
Contents	6
Evaluating the Abuse Potential of Lenabasum, a Selective Cannabinoid Receptor 2 Agonist	6
Interactions of VMAT2 with CDCrel-1 and Parkin in Methamphetamine Neurotoxicity (Abstract ID: 163329)	6
Effects of the Glycine Transporter-1 Inhibitor Iclepertin (BI 425809) on Sensory Processing, Neural Network Function, and Cognition in Animal Models Related to Schizophrenia	6
Impact of Morphine Dependence and Withdrawal on Economic Demand for Opioids and Stimulants in Rats (Abstract ID: 159560)	6
The Ribosome Associated Gene Transcripts During Oxidative Stress	6
Editorial Board	6
Unconventional Mechanisms of Novel Positive Allosteric Modulators of NDMA Receptors	6
Leveraging a Novel GPCR ITIM Motif that Drives Gradient Signaling for Targeted Antibody Design and Peptide Inhibitor Development	6
High Fructose - High-Fat Diet Accelerates Non-Alcoholic Fatty Liver Disease Possibly Mitigating Hepatic Nuclear Lipocalin Prostaglandin D2 Synthase	6
Old Dog, New Tricks: Oral Dosing Hypertensive Rats with Anti-Inflammatory Agent Colchicine Gives Vascular Remodeling and Function Recovery	6
Visceral analgesic effect of eluxadoline (Viberzi): A central action	6
Organic Cation Transporter 3 and Serotonin Transporter Contribute to Fear Memory Recall and Serotonin Clearance in Basolateral Amygdala (Abstract ID: 169244)	6
Design and Synthesis of Dual Inhibitors Targeting Soluble Epoxide Hydrolase and Fatty Acid Amide Hydrolase (Abstract ID: 158843)	6
Cinnabarinic Acid Provides Hepatoprotection Against Nonalcoholic Fatty Liver Disease	6
The Dual Role of the Natural Compound Cardamonin in Triple Negative Breast Cancer	6
Local Knockout of the Gb5-R7 Complex (Gnb5) in the Hypothalamus Causes Increased BMI and Brain Mass in Mice	6
Editorial Board	6
In vitro antiglycation and protein cross-link breakage effects of Murraya koenigii leaf extracts and their phytochemical composition	6
Correction to “NCP, a Dual Kappa and mu Opioid Receptor Agonist, Is a Potent Analgesic Against Inflammatory Pain without Reinforcing or Aversive Properties”	5
The compulsion zone theory of cocaine self-administration behavior in rats explains the effects of fixed ratio magnitude on inter-injection intervals	5
Characterization of a Stem-Cell Derived Hepatocyte-Like Cell Model to Study Fetal/Neonatal Xenobiotic Metabolism (Abstract ID: 163750)	5
Concomitant Mild Traumatic Brain and Burn Injury Elicits a Unique Gene Expression Profile within the Brain	5
Elucidating Signaling Mechanisms and Pharmacology for the Brain Orphan Receptor GPR37	5
Characterization of Drug Binding to Liver Fatty Acid Binding Protein (FABP1) and Its Effect on Diclofenac Metabolism by CYP2C9	5
The Melatonin Derivative ITH13001 Prevents Hypertension and Cardiovascular Alterations in Angiotensin II-Infused Mice	5
Buprenorphrine Alters Anxiety-like Behavior in C57BL/6J (B6) Mice as a Function of Dose, Sex, and Obesity	5
Pharmacokinetics of Panobinostat: Interspecies Difference in Metabolic Stability	5
Positive Allosteric Modulation of the Mu Opioid Receptor Does Not Potentiate Opioid-Mediated Side Effects	5
Botulinum Toxin A, a Better Choice for Skeletal Muscle Block in a Comparative Study With Lidocaine in Rats	5
Exposure to Electronic Waterpipes Increases the Risk of Occlusive Cardiovascular Disease in C57BL/6J Mice	5
Therapeutic Basis of Generic Substitution of Antiseizure Medications	5
Development of a Machine Learning Algorithm Using Electronic Medical Records to Predict Short-Term Stroke Risk Locally (Abstract ID: 191545)	5
Role of Neuromedin S-expressing Ventral Tegmental Area Neurons in Morphine Behavior	5
Distinct Functional Roles of HNF1A-AS1 Transcripts in Regulating Drug-metabolizing Enzymes (Abstract ID: 190751)	5
Reinforcing Effects of Fentanyl Analogs Found in Illicit Drug Markets	5
Oral Oxycodone Self Administration in Rats with a History of Responding Under a Multiple Schedule for Ethanol and Food or Oxycodone and Food	5
Significance of Organic Anion Transporter 2 and Organic Cation Transporter 2 in Creatinine Clearance: Mechanistic Evaluation Using Freshly Prepared Human Primary Renal Proximal Tubule Cells	5
Influence of CYP2B6 Pharmacogenetics on Stereoselective Inhibition and Induction of Bupropion Metabolism by Efavirenz in Healthy Volunteers	5
Cardioprotective Effects of 1-(3,6-Dibromo-carbazol-9-yl)-3-Phenylamino-Propan-2-Ol in Diabetic Hearts via Nicotinamide Phosphoribosyltransferase Activation	5
Correction to “Central Nervous System Delivery of the Catalytic Subunit of DNA-Dependent Protein Kinase Inhibitor Peposertib as Radiosensitizer for Brain Metastases”	5
Identification of Small Molecule RGS10 Modulators in a Microglial Cell Model of Neuroinflammation	5
Development of a High-Throughput Screening Assay to Identify Inhibitors of Infection-Induced Inflammation of the Human Fetal Membranes (Abstract ID: 168198)	5
Cell Free Targeted Therapy for T-cell Acute Lymphoblastic Leukemia	5
Proximity Labeling-Based Mapping of the EAAT3 Interactome and Identification of C-terminal Interacting Partners	5
Poly (ADP) Ribose Polymerase (PARP)-1 as a novel therapeutic target for alleviating the manifestations of Atopic Dermatitis	5
Evidence for Alpha7 Nicotinic Receptor Activation During the Cough Suppressing Effects Induced by Nicotine and Identification of ATA-101 as a Potential Novel Therapy for the Treatment of Chronic Cough	5
Death receptor 5 agonists mitigate cardiac pathology in a chronic isoproterenol-induced cardiac remodeling and dysfunction	5
Clinical development of the GluN2B-selective NMDA receptor inhibitor NP10679 for the treatment of neurologic deficit after subarachnoid hemorrhage	5
Clinical Pharmacology: A new article type for The Journal of Pharmacology and Experimental Therapeutics	5
Development of Curcumin-Related Lead Compounds for Treatment of Melanoma: Synthesis, Antiproliferative Activity, and Mechanistic Investigation (Abstract ID: 159217)	5