Journal of Pharmacology and Experimental Therapeutics

Article	Citations
Special section on Breaking Barriers in Women's Cancer Treatment: Innovative Approaches and Experimental Therapeutics—Editorial	258
Table of Contents	84
Editorial Board	57
Response to Comments on “Ocular Pharmacokinetics of Brimonidine Drug Delivery System in Monkeys and Translational Modeling for Selection of Dose and Frequency in Clinical Trials”	52
The Modulatory Effects of Citrus Flavonoid Hesperetin on Nrf2 Expression and NF-kB Signaling Pathway in LPS-Activated BV-2 Microglial Cells	49
β-adrenoceptor-mediated vasodilation is enhanced by acute colchicine-treatment in men with essential hypertension	47
Neurostimulation of the renal nerves as a novel therapeutic option for obstructive sleep apnea treatment	41
Podocyte injury triggers the formation of intercellular bridges	41
Molecular Dynamics Studies for Nirmatrelvir and the Main Protease from Variants of the Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2)	38
Editorial Board	37
Enhancing the Scalability and Therapeutic Window of Taccalonolide-based Chemotherapeutics for the Treatment of Triple-negative Breast Cancers	36
Acute and Subchronic GPR171 Agonism Affects Anxiety and Depression in Female Mice	36
Inhibiting the Cytotoxic Effect of Tubulin Polymerization-Promoting Protein (TPPP/p25α) Induced α-synuclein Aggregates Via 20S Proteasome Enhancement	33
GPR55 Antagonist KLS-13019 Prevents and Reverses Chemotherapy-Induced Peripheral Neuropathy (CIPN) in Rats	33
Translational Pharmacokinetic/Pharmacodynamic Modeling of Targeted mRNA-LNP Therapeutics	32
Changes of ACE-2 related-miR-200b-3p expression over time are a predictive factor of long hospitalization for COVID-19: in silico, machine learning and validation analysis	30
Cholesterol Enrichment Alters Compartmentalization of G-Proteins Into Lipid Raft Microdomains	29
Sex Differences in the Behavioral and Metabolic Effects of Prenatal Stress in Early but not Late Adulthood in Mice	29
Calcium Channel Blockers as Novel Therapeutic Agents for Triple-Negative Breast Cancer	29
A novel UVA-labile β-adrenergic agonist allows for optical control of subcellular signaling	28
Mechanistic Insights into Xanthohumol-Induced Apoptosis and Cytokine Modulation in Multiple Myeloma with a Focus on Nanoparticle Targeting Strategies	28
Behavioral effects of fentanyl in presence or absence of chronic neuropathic pain in male and female rats	27
Regulated Trafficking of GABA Transporters, GAT1 and GAT3, in Response to Methamphetamine	26
Sigma Ligand-mediated Cytosolic Calcium Modulation in BV2 Microglia Cells	26
Contents	26

In Silico Simulations of Physicochemical and ADMET Properties of Curcumin Glucoside Derivatives (Abstract ID: 161637)	25
Metabotropic Glutamate Receptor 1 (mGlu1) Positive Allosteric Modulators Exhibit Differential Effects at the mGlu1/5 Heterodimer (Abstract ID: 162597)	24
Chronic Opioid Use Leads to Exacerbated Hypersensitivity and Transcriptomic Changes in a Post-Operative Pain Model (Abstract ID: 165327)	24
DNAJC13 Regulates GPCR Sorting at Endosomes (Abstract ID: 161875)	23
Development and Validation of Cell-Based Hydrogen Peroxide-Induced Senescence Model of Liver Fibrosis: HepG2 /Huh-7 and LX2 3D Spheroid (Abstract ID: 169675)	23
Fatty Acid Metabolizing Cytochrome P450 4F11 as a Novel Drug Target for Lung Cancer Treatment	22
Orexin in the Dorsal Periaqueductal Gray Matter Fails to Modulate Anxiety- and Panic-like Behaviors in a Dangerous Environment (Abstract ID: 191219)	22
Dual Targeting of PI3K/mTOR Oncogenic Pathway Is a Promising Therapeutic Strategy for High-Risk Neuroblastoma (Abstract ID: 170196)	22
Managing Iron Overload: A Gut Check	21
The Nrf2 activator tBHQ promotes OVA-Elicited Food Allergy in Mice	21
Role of cyclophilin A overexpression in angiotensin II/mechanical stretch-induced vascular remodeling: Protective effect of adiponectin	21
Pharmacological Characterization of a-Ethyltryptamine-based 5-HT2A Receptor Agonists for Therapeutic Use (Abstract ID: 190197)	20
Examining the Nephrotoxicity Induced by Benzalkonium Chlorides in 2D and 3D-Cultured Human Proximal Tubule Epithelial Cells (Abstract ID: 161924)	20
Hormonal Regulation of Cannabinoid-Induced Antinociception (Abstract ID: 192216)	20
Molecular Characterization and Bio-Fabrication of Bioactive Metabolites Derived from Thermotolerant Brucella Intermedia-DAZD and Its Antimicrobial Potentials (Abstract ID: 169939)	20
Recent Developments in On-Demand Voiding Therapies	20
An Integrative Approach to Elucidate Mechanisms Underlying the Pharmacokinetic Goldenseal-Midazolam Interaction: Application of In Vitro Assays and Physiologically Based Pharmacokinetic Models to Unde	19
Evidence for cytoprotective autophagy in response to HER2-targeted monoclonal antibodies	19
Effects of hsa-miR-9-3p and hsa-miR-9-5p on Topoisomerase II β Expression in Human Leukemia K562 Cells with Acquired Resistance to Etoposide	19
Lithium, a GSK-3β inhibitor, attenuates depression and chemobrain induced by doxorubicin in rats: Emphasis on brain BDNF/TrkB/Akt/GSK-3β/mTOR/Nrf2/HO-1 axis	18
Development and Characterization of a Cytochrome P450 CYP3A7 Fetal Hepatocyte-Like Cell Model Derived from Induced Pluripotent Stem Cells	18
PhRMA Foundation Trainee Challenge Award: Pharmacology of Next Generation Therapeutics	17
Beneficial Effects of the Direct AMP-Kinase Activator PXL770 in In Vitro and In Vivo Models of X-Linked Adrenoleukodystrophy	17
Effects of Volatile Anesthetics versus Ketamine on Blood-Brain Barrier Permeability via Lipid-Mediated Alterations of Endothelial Cell Membranes	17
Biodistribution of Agmatine to Brain and Spinal Cord after Systemic Delivery	17
Detection of kdr and rdl Mutations in Permethrin-Exposed Anopheles Gambiae (Abstract ID: 231187)	16
Activation of Metabotropic Glutamate Receptors 3 and 5 Rescues Schizophrenia-Like Glutamatergic Abnormalities in Corticolimbic Circuits and Cognitive Deficits (Abstract ID: 231744)	16
Sex Differences in the Repeated Co-Exposure of Nicotine and Ethanol Vapor on Central Amygdala Neuronal Activity in C57BL/6J Mice (Abstract ID: 226032)	16
Investigating Shared Mechanisms of Arrestin Protein Activation and Cargo Recognition (Abstract ID: 235956)	16
Mechanistic PBPK Modeling Identifies Oral Microenvironment Determinants of Buccal Midazolam Exposure (Abstract ID: 269811)	16
Linking Chronic Obesity to Gut–Liver Axis Dysfunction in C57BL/6 Mice (Abstract ID: 269066)	16
Social stress cue exposure heightens opioid preference and locus coeruleus neuroimmune activity in female rats	16
Developing IVIVE and PBPK Modeling Approaches to Predict Transporter-Mediated Drug Secretion Into Human Breast Milk (Abstract ID: 229190)	15
Preclinical Development of First-in-Class Selective Muscarinic Acetylcholine M2 Receptor Antagonists (Abstract ID: 274524)	15
Differential Effects of Antifungal Agents on Melanin Synthesis in Normal Human Melanocytes and Human Primary Metastatic Melanoma Cells (Abstract ID: 231495)	15
In Silico Antimycobacterial Potential of Annona Muricata Leaf Extracts (Abstract ID: 232252)	15
Synergistic Analgesia With Novel Non-Opioid Alpha-2 Adrenergic Receptor Subtype-Preferring Agonists (Abstract ID: 235406)	15
The Mu Opioid Receptor Positive Allosteric Modulator BMS-986122 Attenuates Opioid Tolerance (Abstract ID: 225965)	15
Impact of Chronic Ethanol Intake on Intervertebral Disc Degeneration and Pain in a Mouse Model of Chronic Low Back Pain (Abstract ID: 232995)	15
Juvenile Exposure to Doxorubicin Sensitizes Skeletal Muscle to Adult-Onset Angiotensin II-Induced Atrophy in C57BL/6 Mice (Abstract ID: 227942)	14
The Effects of the Dopamine Transporter Ligands JJC8-088 and JJC8-091 on Cocaine versus Food Choice in Rhesus Monkeys	14
Antithrombotic potential of lornoxicam and possible mechanistic pathways	14
Tear Film Proteome Signatures of Acute Ocular Injury Following Vesicant Exposure (Abstract ID: 230253)	14
Rapid Characterization of the Functional and Pharmacological Consequences of Cantú Syndrome KATP Channel Mutations in Intact Cells	14
Compounds with dual glutaminase inhibition and Nrf2 activation activities enhance morphine analgesia and reduce pain sensitization in chemotherapy-induced peripheral neuropathy mouse model	14
Neurotoxic Methamphetamine Exposure Alters Mitochondrial Morphology in Ventral Tegmental Area Dopaminergic Neurons (Abstract ID: 231899)	14
Amlodipine use in Mild Cognitive Impairment reduces the risk of incident dementia in National Alzheimer’s Coordinating Center participants aged ≥55 years from 2014-2019	14
Thermogenic Modulation Reduces Adipose Tissue Inflammation and Complications of Early Metabolic Dysfunction: Impact on Mitochondrial Proteomics and Adipose Lipidomics (Abstract ID: 159767)	14
Ketamine's Antidepressant-Like Effects and Discriminative Stimulus Properties Compared to Imipramine and Fluoxetine in Rats and Mice (Abstract ID: 236432)	14
Selective Deletion of β2-Aderergic Receptor in Myeloid Cells Improve Cardiac Function After Myocardial Infarction via Annexin A1 (Abstract ID: 165406)	13

Amlodipine Protects Against the Bruton's Tyrosine Kinase (BTK) Inhibitor, Acalabrutinib-Induced Endothelial Dysfunction (Abstract ID: 171265)	13
A Novel Sulindac Derivative Protects against Oxidative Damage by a Cyclooxygenase-Independent Mechanism	13
Neuroprotection in C. Elegans Models of Parkinson's Disease: Discovering Therapeutics Via Small Molecule High Throughput Screening and RNA Interference (Abstract ID: 160193)	13
Quantitative Systems Pharmacology and Machine Learning: A Match Made in Heaven or Hell?	13
The ß2-AR agonist Formoterol Restores Hallmark Features of Adrenal Cushing's Syndrome (Abstract ID: 160243)	13
Angiotensin-(1-7) or Alamandine Modulates Bioenergetics in the Human Brain Microvascular Endothelial Cells Aging In Vitro (Abstract ID: 161351)	13
In-Silico Discovery of CIP2A Inhibitors for Alzheimer's Disease Therapy (Abstract ID: 164859)	13
Discovery of a Potent and CNS-penetrable Anti-mitotic Agent That Shows Efficacy against Tumor Growth and Metastasis (Abstract ID: 189061)	13
Neurosteroid mitigation of developmental neurological dysfunction, long-term epileptic biomarkers, chronic neuroinflammation, and neurodegeneration in a pediatric rat model of organophosphate exposure	13
Pharmacokinetics and Safety of the Lysine Specific Histone Demethylse-1 Inhibitor Seclidemstat in Cats with Oral Squamous Cell Carcinoma (Abstract ID: 166436)	13
A Massively Parallel Reporter Assay Library to Screen Short Synthetic Promoters in Mammalian Cells (Abstract ID: 159301)	13
Evaluating the Impact of a Low Dose of LSD on EEG Spectral Signature in Participants with Depressed Mood (Abstract ID: 163720)	13
Enantioselective Metabolism of Arachidonic Acid by Human Cytochrome P450s Using LC-MS/MS (Abstract ID: 189543)	12
Overcoming Cetuximab Resistance in Colorectal Cancer through Inhibition of HGF Processing	12
Intracellular metabotropic glutamate receptor 5 (mGlu5) triggers ER calcium release distinct from cell surface counterparts in striatal neurons	12
Using a Clinical Pharmacology Elective to vertically Integrate Basic Pharmacology Content Beyond the Pre-clerkship Phase	12
Response to Comments on “Increasing Enzyme Mannose-6-Phosphate Levels but Not Miglustat Coadministration Enhances the Efficacy of Enzyme Replacement Therapy in Pompe Mice”	12
CCK-58 and CCK-8 Are Non-Equivalent in Signal Transduction at Human Cholecystokinin 1 Receptor (CCK1R) in Transfected Cell Lines (Abstract ID: 188910)	12
Formulation, Characterization and Pharmacokinetic Study of a Novel Lipid Nanoparticle Formulation of Bisphosphonate Conjugated Angiotensin 1-7 (Abstract ID: 190780)	12
Respective Roles of CYP4F2 and CYP2D6 in the Formation of Even- and Odd-Carbon Carboxylic Acid Metabolites of Benzalkonium Chloride in Human Hepatocytes (Abstract ID: 170055)	12
Protective effect of 2-hydroxyestrone and 2-hydroxyestradiol against chemically induced hepatotoxicity in vitro and in vivo	12
Dissecting the novel anti-obesity mechanism of prostaglandin D2 via DP1 receptor agonism utilizing mouse 3T3-L1 adipocytes as well as primary human subcutaneous adipocytes	12
Roles of Hepatic Bile Acid Transporters in Hepatocellular Carcinoma	12
Pharmacological Modulation of Muscarinic M4 Receptors Reduces Striatal Spontaneous Acetylcholine Release with Little to No Effect on Dopamine In Vivo (Abstract ID: 167167)	12
Discovery and Structure-activity Relationship of Synthetic Cathinone-Derived Acetylcholine M2 Receptor Antagonists (Abstract ID: 162036)	12
Novel Catalytic Antioxidant Formulation Decreases Oxidative Stress, Neuroinflammation and Cognitive Dysfunction in a Model of Nerve Agent Intoxication	12
Proximity Labeling Reveals a Multivalent Scaffold that Targets GRK5 to a Signaling Complex with Beta-Adrenergic Receptors	12
Nanoencapsulation of Curcumin-Piperine Complex for Targeting CYP17A1 in Castration-Resistant Prostate Cancer	12
L-Lactate Binding to Hydroxycarboxylic Acid Receptor 1 (HCAR1) Mediates Cell Signaling and Promotes Brain-Derived Neurotrophic Factor Expression in Mammalian Astrocytes (Abstract ID: 168203)	12
Multi-Omics and Electrophysiological Examination of GABAA Receptors in the Dorsolateral Prefrontal Cortex of Humans with Alcohol Use Disorder (Abstract ID: 189092)	12
Bioinformatic Determination of Potential Protein Targets of Metformin Activity in Hyperlipidemia	11
Preclinical Pharmacokinetic and Pharmacodynamic Evaluation of Intradermal Growth hormone and Insulin Delivery using Novel Microneedles in Guinea pigs and Rats	11
Monensin and its derivatives increase MHC Class I and II presentations in breast cancer	11
Pharmacological and Genetic Preclinical Models of Ghrelin Receptor Functional Selectivity to Investigate Metabolic Disease Pathophysiology	11
No Evidence for Beneficial Empagliflozin Effects in the Kidney of Female Rats in a Streptozotocin-induced Model of Type 1 Diabetes	11
Analgesic and Side Effect Profiles of Novel Alpha-2 Adrenergic Receptor Agonists	11
Targeting HDAC6 in the Dorsal Root Ganglia for the Management of Mechanical Allodynia in Models of Peripheral Nerve Injury	11
Enhancement of Muscarinic Receptor-Induced Contractions by Hydrogen Sulfide-Releasing Compounds in Bovine Isolated Irides	11
MAL-PD Theory/Algorithm Guided Clinical Protocol Design for Computerized Data Analysis and Digital Conclusions in Drug Evaluations for Single Drugs and Combinations	11
Toxicology testing in minipigs of a heroin vaccine intended for clinical treatment of opioid use disorder	11
The neuropeptide receptor GPR83 regulates anxiety-like behavior	11
Editorial Board	11
Quantitative phosphoproteomic analysis defines distinct cAMP signaling networks emanating from AC2 and AC6 in human airway smooth muscle cells	10
Comments on “Ocular Pharmacokinetics of Brimonidine Drug Delivery System in Monkeys and Translational Modeling for Selection of Dose and Frequency in Clinical Trials”	10
Using a rich-lean transition procedure to evaluate putative antianxiety medications	10
A novel loncastuximab-based cucurmosin immunotoxin with high potency in vitro against lymphoma	10
Effects of Arginase Inhibitors and Beta-Blockers on the Proliferation of Cancer Cell (Abstract ID: 230148)	10
Discriminative Stimulus Effects of Ethanol, Alprazolam and Pentobarbital in Rats	10
Spinal Aha1 inhibition improves morphine therapy for pain management	10
Identification of Infigratinib as a Potent Reversible Inhibitor and Mechanism-Based Inactivator of CYP2J2: Nascent Evidence for a Potential In Vivo Metabolic Drug-Drug Interaction with Rivaroxaban	10
Sinomenine alleviates cancer-induced bone pain by promoting p65 ubiquitination and modulating microglial polarization	10
Cover	10
Corrigendum to “Recent Developments in On-Demand Voiding Therapies” [The Journal of Pharmacology and Experimental Therapeutics 390 (2024) 302-317]	10
Mechanism of fructo-oligosaccharides on potentiating GLP-1 release from enteroendocrine cells	10
A “Furious” Effort to Develop Novel 3,4-Methylenedioxymethamphetamine-Like Therapeutics	10
Breaking free from opioids: A turning point in acute pain management	10
Pharmacological and toxicological profiling of JAMC-4/108: targeted induction of apoptosis in human colorectal cancer cells	10
Cdc50a Modifies Phospholipid Specificity to Enhance the Flippase Activity of the Murine P4-Type ATPase, Atp8a1 (Abstract ID: 273373)	10
A Novel Charged Sodium-Channel Blocker, Ntx-1175, Is Effective In Reducing Acute Visceral Hypersensitivity In Vivo	10
Repurposing Retinoic Acid Receptor Gamma Agonist CD437 to Modulate Immune and Inflammatory Response in Methicillin Resistant Staphylococcus Aureus Lung Infection (Abstract id: 222101)	9
Endolysosome Re-Acidification Rescues Lysosomal Progranulin Deficiency Effects and Cell Death (Abstract ID: 232705)	9
Optimization of the NanoBRET Platform for a Screen of Selective Adenylyl Cyclase 8 Inhibitors to Treat Alcohol Use Disorders (Abstract ID: 226063)	9
Developing Tools to Study the Structure and Function of GPCR5B, an Orphan GPCR Involved in Cell-Volume Regulation (Abstract ID: 236385)	9
Cover	9
Multiomics approach to interrogate translational regulation to GPCR signaling and its spatial bias	9
Central Nervous System Delivery of the Catalytic Subunit of DNA-Dependent Protein Kinase Inhibitor Peposertib as Radiosensitizer for Brain Metastases	9
Spinophilin-Dependent Regulation of Striatal Function and Protein Interactions. (Abstract ID: 223409)	9
Chronic Alcohol Consumption Increases Cold and Tactile Sensitivity (Abstract ID: 235215)	9
Muscarinic M4 Receptor Modulation Confers Antipsychotic-Like Efficacy Through Mechanisms Independent of Striatal Dopamine Release (Abstract ID: 230599)	9
The Effects of Taurine on Alcohol-Associated Liver Disease are Dose-Dependent Associated with Alterations of Taurine-Conjugated Bile Acids and FXR-FGF15 Signaling	9
How Do Stress, Salt, and Sex Interact to Affect Rat Proactive Avoidance Learning and Retention, and What Implications Do These Interactions Have for Hypertension? (Abstract ID: 161169)	9
Comparison of the Genomic Activity of an EP4-Receptor and β2-Adrenoceptor Agonist in BEAS-2B Human Bronchial Epithelial Cells: In Search of Compartmentalized, cAMP-Dependent Gene Expression	9
Target Cell Activation of a Structurally Novel NOD-Like Receptor Pyrin Domain-Containing Protein 3 Inhibitor NT-0796 Enhances Potency	9
Weaving Research and Teaching in a Course-Based Undergraduate Research Experience (CURE) Pharmaceutical Sciences Lab (Abstract ID: 229724)	9
Dual Inhibition of Fatty Acid Amide Hydrolase and Soluble Epoxide Hydrolase Reduces Inflammatory and Orofacial Pain in Rats (Abstract ID: 221469)	9
Toward a Comprehensive Profile of MDMA as a Candidate Therapeutic: The Role of the Dopamine-Serotonin Continuum in Prohedonic Efficacy and Abuse Liability (Abstract ID: 228563)	9
Analgesic Properties of the Natural Product Barettin Are Mediated by the 5HT2A/C Receptors (Abstract ID: 165920)	9
Low-density lipoprotein receptor-related protein 1 as a therapeutic target in acute myocardial infarction: From mechanisms to clinical translation	9
Correction to “Protective Effect of Anwulignan on Gastric Injury Induced by Indomethacin in Mice”	9
Polypharmacology as a New Drug Design Approach for Treating Chronic Pain (Abstract ID: 157379)	8

Associations Between Proinflammatory Cytokines, Laboratory-evoked Pain, and Opioid Response Profiles in Healthy Human Subjects	8
Longitudinal Impact of Mnemonics Use on Pharmacy Students’ Exam Performance and Perceptions of Knowledge Retention and Clinical Application	8
Table of Contents	8
Combination of Epigallocatechin 3 Gallate and Ellagic Acid Improves Memory Impairment in a Triple-Transgenic Mouse Model of Alzheimer's Disease (Abstract ID: 170147)	8
SAR Investigation of GPR183 Antagonists for the Treatment of Neuropathic Pain (Abstract ID: 159317)	8
Potential Additive Effects of Ethanol and Methamphetamine Self-Administration in Rats (Abstract ID: 158460)	8
GPR55 Antagonist KLS-13019 Reverses Chemotherapy-Induced Peripheral Neuropathy (CIPN) in Rats	8
Metformin as a Potential Countermeasure for the Central Nervous System Effects of Radiation Exposure	8
The Contribution of Allosteric Interactions to the Long-Lasting Effects of MCAM in Rats (Abstract ID: 157620)	8
Editorial Board	8
Evaluation of systemic and brain pharmacokinetic parameters for repurposing metformin using intravenous bolus administration	8
COL4A1 Exacerbates Ischemic Stroke-Induced Neuronal Apoptosis via Lactate-Depend Lysine Lactylation (Abstract ID: 160754)	8
The Effect of Adolescent Fluoxetine on Neurogenesis and Stress Susceptibility in Adult Mice (Abstract ID: 168215)	8
Ovariectomy Promotes Angiotensin II-induced Renal Dysfunction and Vasopressin Excretion via 12/15-Lipoxygenase	8
The Protective Effect of Panduratin A on Renal Fibrosis in Human Renal Proximal Tubular Cells and Unilateral Ureteral Obstruction Mice (Abstract ID: 160875)	8
TLR4 downregulation protects against cisplatin-induced ototoxicity in adult and pediatric patients with cancer	8
Targeting Epigenetic and Oncogenic Signaling in Medulloblastoma: Comparative Analysis of HDAC/PI3K Dual Targeting and HDAC Inhibition (Abstract ID: 159719)	8
Investigation of the Pharmacokinetics and Anticonvulsant Effect of Selected Oxazolidinone Derivatives in Rats (Abstract ID: 157153)	8
Efficacy of LSD1 Directed Agents is Enhanced with Kinase Signaling Inhibition in Glioblastoma Stem Cells	7
Human Neuromuscular Junction Platform for Investigating Pathogen and Toxin-Induced Dysfunction in Disease and Drug Discovery (Abstract ID: 191678)	7
Chronic Exposure to Organophosphate Pesticides and Elevated Markers of Systemic Inflammation: Possible Neuroinflammatory and Genotoxic Effects	7
EEG studies reveal estradiol-dependent differences in GluN2A-containing NMDAR function	7
EAATs for stroke: to modulate or not to modulate	7
Lung Injury in Mice from Acute Cutaneous Exposure to Vesicating Agent Nitrogen Mustard	7
Impact of Posttranscriptional Modifications in Novel Bioengineered RNAs (Abstract ID: 163872)	7
Elucidating the Drug-Drug Interaction Potential of Hydroxychloroquine Metabolites due to Direct and Time-Dependent Inhibition of CYP3A	7
Renin-Angiotensin System Components and Arachidonic Acid Metabolites as Biomarkers of COVID-19	7
Characterizing the Role of Ser670 Phosphorylation in Non-canonical Mechanisms of GRK2 Inhibition in Heart Failure	7
Proximity Labeling Uncovers a Novel Putative Role for Spinophilin as a Mediator of Dendritic Protein Homeostasis (Abstract ID: 191477)	7
Activation of CYP3A Enzymes in the Human Liver by Chronic Alcohol Exposure and Its Association with the Functional Effects of CYP3A-CYP2E1 Interactions (Abstract ID: 163729)	7
Protective functions of metformin in LPS-induced H9C2 injury by miR-497-5p/BTRC/IκBα axis-mediated NF-κB pathway activation	7
Neuroimmune Circuitry of Midbrain Dopamine Neurons	7
Dynorphin release in the dorsal nucleus accumbens drives decreased feeding and consummatory reward behavior in mice	7
Generation and Characterization of a Serum Albumin-Humanized Mouse Model For Biomarker Discovery	7
Intestinal Dysbiosis Alters Seizure Burden and Antiseizure Medicine Activity Profile in the Theiler’s Virus Model of Acute Encephalitis	7
Sex Differences in GABA Regulation of Dopamine Release in the Nucleus Accumbens and its Role in Cocaine Use Disorder	7
The Effect of Acute and Chronic Administration of Fluoxetine on R−(−)− DOI Induced Head Twitch Response in Swiss-Webster Mice	7
Chemotherapeutics-Loaded Poly(Dopamine) Core-Shell Nanoparticles for Breast Cancer Treatment	7
Inhibition of Nociception Produced by Structurally Distinct Inhibitors of Fatty Acid Amide Hydrolase and Soluble Epoxide Hydrolase (Abstract ID: 189568)	7
Xylazine-Induced Tolerance and Interactions with Fentanyl (Abstract ID: 191759)	7
High brain-blood barrier permeability highlights a new class of neurolysin activators as promising candidates for stroke treatment: a pilot pharmacokinetic study in mice	7
Neuroprotection in C. Elegans Parkinson’s Disease Models: Discovering Therapeutic Insights via RNAi and Small Molecule High Throughput Screening	7
Regulation of Neuronal Activity by GluD1 Current in Brain Slices	7
Identifying Selective Substrates and/or Inhibitors of Renal Drug Uptake Transporters	7
Assessment of Dextromethorphan on Compulsive Behavior Using the Schedule-Induced Polydipsia Paradigm in Rats	7
Comparison of Δ9-tetrahydrocannabinolic acid A (THCA-A) and Delta-9-tetrahydrocannabinol (THC) in neuronal cell functions	7
A2B adenosine receptor-mediated intracellular calcium mobilization: Involvement of Gi, Gq, Gs, β-arrestins, and protein kinase C	7
Deciphering immunological mechanisms underlying the efficacy of nanoparticle-based vaccines and novel adjuvants against Opioid Use Disorder (OUD)	7
Interactions of VMAT2 with CDCrel-1 and Parkin in Methamphetamine Neurotoxicity (Abstract ID: 163329)	6
8-Aminoinosine and 8-Aminohypoxanthine Inhibit Purine Nucleoside Phosphorylase and Exert Diuretic and Natriuretic Activity	6
Cinnabarinic Acid Provides Hepatoprotection Against Nonalcoholic Fatty Liver Disease	6
The Platelet Regulator of G-Protein Signaling 16 Negatively Regulates Platelet Function (Abstract ID: 235189)	6
Characterization of the Metabolic and Emetic Effects of GLP-1 and Dual GLP-1/GIP Agonists in Suncus Murinus (Abstract ID: 226801)	6
Design of ERK1/2 Signaling Modulators and Effects on Proliferation and Airway Remodeling Biomarkers in Lung Fibroblasts (Abstract ID: 226681)	6
Tumor-Selective CBD-IL12 Immunotherapy for Recurrent Glioblastoma (Abstract ID: 236152)	6
Investigating the effectiveness and adverse events of medicinal cannabis for patients with muscle spasticity or spasms	6
Targeting of Brahma-related gene-1 (BRG1) overcomes paclitaxel-induced multidrug resistance caused by overexpression of the subset of ATP-binding cassette (ABC) transporters	6
Renal Cytotoxicity of the E-Vaping Flavoring Agent Menthol	6
Comparison of naloxone, naltrexone, nalmefene, and methocinnamox for preventing and reversing the discriminative stimulus effects of buprenorphine and carfentanil in rats discriminating fentanyl from	6
Structural Insights Into G Protein-Coupled Receptor Kinase 5. Phosphorylation of Neurotensin Receptor 1 (Abstract ID: 222445)	6
Organic Cation Transporter 3 and Serotonin Transporter Contribute to Fear Memory Recall and Serotonin Clearance in Basolateral Amygdala (Abstract ID: 169244)	6
Design and Synthesis of Dual Inhibitors Targeting Soluble Epoxide Hydrolase and Fatty Acid Amide Hydrolase (Abstract ID: 158843)	6
Impact of SLC43A3/ENBT1 Expression and Function on 6-Mercaptopurine Transport and Cytotoxicity in Human Acute Lymphoblastic Leukemia Cells	6
Potential Utility of the Serum Albumin Knockout Mouse Model for a Better Understanding of the Interplay Between Plasma Protein Binding and Pharmacokinetics (Abstract ID: 232152)	6
NOSH-aspirin (NBS-1120) inhibits estrogen receptor–negative breast cancer in vitro and in vivo by modulating redox-sensitive signaling pathways	6
Comparative Analysis of Dietary Interventions Targeting Immune and Metabolic Dysfunction in Obese Male Mice (Abstract ID: 235197)	6
Understanding the Mechanism Underlying Sex Differences in the Effectiveness of Varenicline (Chantix) (Abstract ID: 228639)	6
Chimera Design of TRUPATH Sensors Detects Previously Missed Activation of Gs by Promiscuous G Protein Coupled Receptors (Abstract ID: 231347)	6
Antiproliferative effects of dihydrotanshinone I on autosomal dominant polycystic kidney disease via immunomodulation	6
The Role of Gender Pharmacogenetics in the Personalization of Drug Treatment	6
Effects of the Glycine Transporter-1 Inhibitor Iclepertin (BI 425809) on Sensory Processing, Neural Network Function, and Cognition in Animal Models Related to Schizophrenia	6
Crosstalk between inflammation, voiding dysfunction, and psychiatric symptoms: novel hypothesis and therapeutics for urinary incontinence	6
ADH Inhibition by the KOR Agonist, Difelikefalin, Enhances Diuretic Responses to Furosemide in HFpEF ZSF1 Rats Despite Sex-Dependent Differences During Diuretic Resistance (Abstract ID: 231360)	6
Sigma-2 Receptor: A Ligand-Regulated Scaffold Protein in Cholesterol Homeostasis (Abstract ID: 222436)	6
Impact of Morphine Dependence and Withdrawal on Economic Demand for Opioids and Stimulants in Rats (Abstract ID: 159560)	6
Spinal Hsp90 Inhibition Augments Opioid-Induced Antinociception via Upregulation of GAT-2 Expression and GABA Reuptake (Abstract ID: 164345)	6
Contents	6
Combined stress and alcohol exposure: Synergistic effects on alcohol-seeking behaviors and neuroinflammation	6
Sex Differences in the Effects of Chronic Stress, Chronic Corticosterone and Prefrontal Cortical REDD1 Overexpression on Pavlovian Autoshaping Behavior in Rats (Abstract ID: 228574)	6
PLPP5 Links Fatty Acid Oxidation to Clofarabine Resistance in AML (Abstract ID: 231067)	6
Targeting Complement Pathway in Mitigating Neuroinflammation and Cognitive Impairment in Metabolic Dysfunction (Abstract ID: 225650)	6
Ellagic Acid (EA) Promotes Osteoblastic Differentiation of Dental Pulp-Derived Stem Cells (DPSCs) by Upregulating KLF2 and by Inducing Autophagy/Mitophagy	6
DBeQ derivative targets vacuolar protein sorting 4 functions in cancer cells and suppresses tumor growth in mice	6
Cannabidiol interactions with Δ-9-tetrahydrocannabinol on antinociception after carrageenan-induced inflammatory pain in male and female rats	6
Investigating the Thrombin Receptor (PAR1) as a Regulator of Myelin Regeneration (Abstract ID: 224607)	6
Genetically Encoded Probes and Peptide-Based Compounds to Inhibit Gαs Signaling in Cells (Abstract ID: 228310)	6
Editorial Board	6
Poly (ADP) Ribose Polymerase (PARP)-1 as a novel therapeutic target for alleviating the manifestations of Atopic Dermatitis	5
Characterization of Drug Binding to Liver Fatty Acid Binding Protein (FABP1) and Its Effect on Diclofenac Metabolism by CYP2C9	5
Oral Oxycodone Self Administration in Rats with a History of Responding Under a Multiple Schedule for Ethanol and Food or Oxycodone and Food	5
Perturbation of Space-Time Gene Expression of the Liver Lobule by 2,3,7,8-Tetrachlorodibenzo-p-dioxin	5
The compulsion zone theory of cocaine self-administration behavior in rats explains the effects of fixed ratio magnitude on inter-injection intervals	5
Elucidating Signaling Mechanisms and Pharmacology for the Brain Orphan Receptor GPR37	5
Reinforcing Effects of Fentanyl Analogs Found in Illicit Drug Markets	5
Identification of Small Molecule RGS10 Modulators in a Microglial Cell Model of Neuroinflammation	5