Journal of Pharmacology and Experimental Therapeutics

Article	Citations
Neurotoxicity Profiling of Aluminum Salt-Based Nanoparticles as Adjuvants for Therapeutic Cancer Vaccine	133
HM15912, a Novel Long-Acting Glucagon-Like Peptide-2 Analog, Improves Intestinal Growth and Absorption Capacity in a Male Rat Model of Short Bowel Syndrome	127
TAK-994, a Novel Orally Available Brain-Penetrant Orexin 2 Receptor-Selective Agonist, Suppresses Fragmentation of Wakefulness and Cataplexy-Like Episodes in Mouse Models of Narcolepsy	69
Competitive Interactions Between Propofol and Diazepam: Studies in GABAA Receptors and Zebrafish	56
Response to Comments on “Ocular Pharmacokinetics of Brimonidine Drug Delivery System in Monkeys and Translational Modeling for Selection of Dose and Frequency in Clinical Trials”	51
Managing Iron Overload: A Gut Check	46
Editorial Board	45
Pharmacokinetic/Pharmacodynamic Modeling of Dexamethasone Anti-Inflammatory and Immunomodulatory Effects in LPS-Challenged Rats: A Model for Cytokine Release Syndrome	35
Central Nervous System Distribution of Panobinostat in Preclinical Models to Guide Dosing for Pediatric Brain Tumors	33
Pharmacological Profile of Difamilast, a Novel Selective Phosphodiesterase 4 Inhibitor, for Topical Treatment of Atopic Dermatitis	32
Assessing Dose- and Sex-Dependent Antinociceptive Effects of Cannabidiol and Amitriptyline, Alone and in Combination, and Exploring Mechanism of Action Involving Serotonin 1A Receptors	32
Cannabinoid Tolerance in S426A/S430A x β-Arrestin 2 Knockout Double-Mutant Mice	31
Combining SOS1 and MEK Inhibitors in a Murine Model of Plexiform Neurofibroma Results in Tumor Shrinkage	29
Role of ERK1/2 Signaling in Cinnabarinic Acid-Driven Stanniocalcin 2–Mediated Protection against Alcohol-Induced Apoptosis	26
Rapid Characterization of the Functional and Pharmacological Consequences of Cantú Syndrome KATP Channel Mutations in Intact Cells	26
Special Section on Medical Countermeasures, From Bench to Battlefield: Translating Experimental Therapies for Effective Combat Against Chemical Threats–Editorial	25
Generation and Characterization of Mirikizumab, a Humanized Monoclonal Antibody Targeting the p19 Subunit of IL-23	24
Agent-Based Modelling Reveals the Role of the Tumor Microenvironment on the Short-Term Success of Combination Temozolomide/Immune Checkpoint Blockade to Treat Glioblastoma	23
The Involvement of Unfolded Protein Response in the Mechanism of Nitrogen Mustard–Induced Ocular Toxicity	21
[11C]Paraoxon: Radiosynthesis, Biodistribution and In Vivo Positron Emission Tomography Imaging in Rat	21
pH Dependence of a GPR4 Selective Antagonist Hampers Its Therapeutic Potential	19
Progress and Challenges in Developing Medical Countermeasures for Chemical, Biological, Radiological, and Nuclear Threat Agents	19
The Potential of Cannabichromene (CBC) as a Therapeutic Agent	19
Humans and Rodents: The Case of hOAT4 and mOat5	19
Modulation of the Immune Response to Severe Acute Respiratory Syndrome Coronavirus 2 Vaccination by Nonsteroidal Anti-Inflammatory Drugs	19

The National Center for Complementary and Integrative Health: Priorities for Cannabis and Cannabinoid Research	18
Antinociceptive Effects of α2/α3-Subtype-Selective GABAA Receptor Positive Allosteric Modulators KRM-II-81 and NS16085 in Male Rats: Behavioral Specificity	18
Sex Differences in the Neural and Behavioral Effects of Acute High-Dose Edible Cannabis Consumption in Rats	18
Identification and Characterization of ACP-5862, the Major Circulating Active Metabolite of Acalabrutinib: Both Are Potent and Selective Covalent Bruton Tyrosine Kinase Inhibitors	18
Table of Contents	18
Neuroprotectant Activity of Novel Water-Soluble Synthetic Neurosteroids on Organophosphate Intoxication and Status Epilepticus-Induced Long-Term Neurological Dysfunction, Neurodegeneration, and Neuroi	18
The Effects of Chronic Naltrexone on Reinstatement of Opioid-Induced Drug-Seeking Behavior and Antinociception	18
Dopamine D1-Like Receptor-Mediated Insurmountable Blockade of the Reinforcing Effects of Cocaine in Rats	17
An Integrative Approach to Elucidate Mechanisms Underlying the Pharmacokinetic Goldenseal-Midazolam Interaction: Application of In Vitro Assays and Physiologically Based Pharmacokinetic Models to Unde	17
A Promise to Keep, but Miles to Go Before We Sleep…	17
Quantitative Systems Pharmacology and Machine Learning: A Match Made in Heaven or Hell?	17
A Novel Truncated Liver Enriched Antimicrobial Peptide-2 Palmitoylated at its N-Terminal Antagonizes Effects of Ghrelin	17
Quantitative Prediction of OATP-Mediated Disposition and Biliary Clearance Using Human Liver Chimeric Mice	17
A Murine Model of Vesicant-Induced Acute Lung Injury	16
The Intoxication Equivalency of 11-Hydroxy-Δ9-Tetrahydrocannabinol Relative to Δ9-Tetrahydrocannabinol	16
Protein-Based Nanocarriers and Nanotherapeutics for Infection and Inflammation	16
Beclin-1–Derived Peptide MP1 Attenuates Renal Fibrosis by Inhibiting the Wnt/β-Catenin Pathway	16
Analgesic Properties of Next-Generation Modulators of Endocannabinoid Signaling: Leveraging Modern Tools for the Development of Novel Therapeutics	16
Myocardial SERCA2 Protects Against Cardiac Damage and Dysfunction Caused by Inhaled Bromine	16
The Effects of the Dopamine Transporter Ligands JJC8-088 and JJC8-091 on Cocaine versus Food Choice in Rhesus Monkeys	16
Initial Characterization of a Transgenic Mouse with Overexpression of the Human H1-Histamine Receptor on the Heart	16
Complexity in Hepatic Insulin Resistance – Unraveling the Role of Ubiquitin-Specific Protease 14 in Protein Homeostasis of Metabolic Transcription Factors	15
Biodistribution of Agmatine to Brain and Spinal Cord after Systemic Delivery	15
Table of Contents	15
Mechanistic Model Describing the Time Course of Humoral Immunity Following Ad26.COV2.S Vaccination in Non-Human Primates	15
Recent Developments in On-Demand Voiding Therapies	15
Cyclooxygenase Inhibitors and Cancer: The Missing Pieces	15
Effects of Volatile Anesthetics versus Ketamine on Blood-Brain Barrier Permeability via Lipid-Mediated Alterations of Endothelial Cell Membranes	15
Central Nervous System Distribution of the Ataxia-Telangiectasia Mutated Kinase Inhibitor AZD1390: Implications for the Treatment of Brain Tumors	14
Sensory-Motor Neuropathy in Mfn2 T105M Knock-in Mice and Its Reversal by a Novel Piperine-Derived Mitofusin Activator	14
Sodium-Glucose Cotransporter-2 Inhibition Exacerbates Hepatic Encephalopathy in Biliary Cirrhotic Rats	14
Methocinnamox is a Potent and Long-Acting Antagonist that can Prevent and Reverse Opioid-Induced Respiratory Depression	14
Special Section on Nanotherapeutics in Cancer Research—Editorial	14
Contents	13
Ventilatory Effects of Fentanyl, Heroin, and d-Methamphetamine, Alone and in Mixtures in Male Rats Breathing Normal Air	13
A Special Section on Clinical Pharmacology—Editorial	13
Editorial Board	13
Effects of hsa-miR-9-3p and hsa-miR-9-5p on Topoisomerase II β Expression in Human Leukemia K562 Cells with Acquired Resistance to Etoposide	13
Treatment of Sulfur Mustard Corneal Injury by Augmenting the DNA Damage Response (DDR): A Novel Approach	13
The Evolving Challenge of New Psychoactive Substances: Understanding the Risks and Behavioral Effects of Novel Analogs of Dissociative Anesthetics	13
Non-Coding RNAs in Clinical Practice: From Biomarkers to Therapeutic Tools	13
Editorial Board	13
Long-Term Neuropsychiatric Developmental Defects after Neonatal Organophosphate Exposure: Mitigation by Synthetic Neurosteroids	13
Editorial Board	12
The β-Blocker Carvedilol and Related Aryloxypropanolamines Promote ERK1/2 Phosphorylation in HEK293 Cells with KA Values Distinct From Their Equilibrium Dissociation Constants as β2-Adrenoceptor Antag	12
Correction to “Specific Lowering of Asymmetric Dimethylarginine by Pharmacological Dimethylarginine Dimethylaminohydrolase Improves Endothelial Function, Reduces Blood Pressure and Ischemia-Reperfusio	12
A Novel Integrated Pharmacokinetic-Pharmacodynamic Model to Evaluate Combination Therapy and Determine In Vivo Synergism	12
Methyl 2-[3-(4-hydroxyphenyl)prop-2-enoylamino]-3-phenylpropanoate Is a Potent Cell-Permeable Anti-Cytokine Compound To Inhibit Inflammatory Cytokines in Monocyte/Macrophage-Like Cells	12
The Novel, Clinical-Stage Soluble Guanylate Cyclase Activator BI 685509 Protects from Disease Progression in Models of Renal Injury and Disease	12
NP10679: a new horizon for neuroprotection in aneurysmal subarachnoid hemorrhage	12

Opening of Intermediate Conductance Ca2+-Activated K+ Channels in C2C12 Skeletal Muscle Cells Increases the Myotube Diameter via the Akt/Mammalian Target of Rapamycin Pathway	12
Understanding CXCR2 antagonism with a dynamic allosteric ternary complex model	12
Editorial Board	12
Factors Influencing the Central Nervous System (CNS) Distribution of the Ataxia Telangiectasia Mutated and Rad3-Related Inhibitor Elimusertib (BAY1895344): Implications for the Treatment of CNS Tumors	12
CNOT6L deadenylase suppresses cardiac remodeling in heart failure through downregulation of tenascin-C mRNA	12
RNA Interference Targeting Liver Angiopoietin-Like Protein 3 Protects from Nephrotic Syndrome in a Rat Model Via Amelioration of Pathologic Hypertriglyceridemia	12
Effects of 3,3’-Dichlorobiphenyl (PCB-11) on the expression of CYP2A, 2B, and 2F enzymes in the liver and brain of CYP2A6-humanized, CYP2B6-humanized, or wild-type mice	11
Ventilatory Effects of Mu Opioid Receptor Agonist Mixtures	11
Differential effects of kappa opioid receptor activation and blockade on the development of methamphetamine-induced sensitization in adult male and female rats	11
Preclinical Evaluation of the Effects of Trazpiroben (TAK-906), a Novel, Potent Dopamine D2/D3 Receptor Antagonist for the Management of Gastroparesis	11
Cardiac Effects of Novel Histamine H2 Receptor Agonists	11
β-Arrestins Mediate Rapid 5-HT2A Receptor Endocytosis to Control the Efficacy and Kinetics of Serotonin and Psychedelic Hallucinogen Signaling	11
Patient iPSC-based high throughput drug screening identifies drug candidates involved in reduced tauopathy associated with Alzheimer’s disease	11
Methocinnamox Reverses and Prevents Fentanyl-Induced Ventilatory Depression in Rats	11
Announcement - Incoming JPET Editor	11
Integration and Alignment of Pharmacological Principles and Agents in a Preclinical Problem-Based Learning Curriculum Through a Web-Based Interface	11
Effect of Inhibition of Xenobiotic Transporter MRP5/ABCC5 on Neurite Elongation: Screening for MRP5 Inhibitors among Clinically Used Drugs	11
Pharmacovigilance of the COVID-19 Vaccine in Ecuador During the First and Second Doses of Vaccination Campaigns	11
Effects of Dopamine D1-Like Receptor Ligands on Food-Cocaine Choice in Socially Housed Male Cynomolgus Monkeys	11
Differential Susceptibilities of Catecholamines to Metabolism by Monoamine Oxidases	11
Multiomics approach to interrogate translational regulation to GPCR signaling and its spatial bias	11
The hepatocyte estrogen sulfotransferase dictates female sensitivity to T cell-mediated hepatitis independent of estrogens	10
Sigma Ligand-mediated Cytosolic Calcium Modulation in BV2 Microglia Cells	10
Effects of a highly G Protein-Biased Mu Opioid Receptor Agonist, SR-17018, in Non-human Primates	10
Development of GPR183 antagonists for the treatment of neuropathic pain	10
The Nrf2 activator tBHQ promotes OVA-Elicited Food Allergy in Mice	10
Molecular Investigation of the Ameliorative Potentials of Cymbopogon citratus Leaves Extract in Carbon tetrachloride- Induced Hepatotoxicity in rats	10
Comparison of Mustard and Urticant Vesicating Agents’ Induced Cutaneous Lesions in Wild Type and Mast Cell Deficient Mice	10
Role of cyclophilin A overexpression in angiotensin II/mechanical stretch-induced vascular remodeling: Protective effect of adiponectin	10
PXR activation attenuates liver fibrosis by down-regulating LECT2 and disrupting β-catenin/TCF4 interaction	10
Identification of Putative Novel Biomarkers of Organic Anion Transporter 1 and 3 for the Prediction of Transporter-Mediated Drug-Drug Interactions	10
Beta-hydroxyphosphocarnitine modifies the inflammation in rats with non-alcoholic steatohepatitis	10
Behavioral and Neurochemical Effects of Extended Access to Stimulant Self-Administration in Rats	10
The HMGB1/MAPKs/Nrf2 Signaling Arbitrates Hepatoprotection Conferred by Celecoxib in Preeclamptic Weaning Rats	10
Bioisosteric Replacement of Amides Linkers with 1, 2, 3-Triazoles for Improved Pharmacokinetics Without Losing Dopamine D4 Receptor Potency or Selectivity	10
Calcium Channel Blockers as Novel Therapeutic Agents for Triple-Negative Breast Cancer	10
Beta-catenin C-terminus inhibition reduces vascular remodeling by precluding the expression of sphingosine-1-phosphate receptor-1	10
Phenylacetylglutamine causes a pathologic inflammation state through the ß2-adrenergic receptor /cAMP/PKA/NF-κB pathway in diabetes	10
Targeting the TAK1/TNF signaling pathway with novel pharmacological inhibitors	10
Structure, Function, and Pharmacology of Delta Opioid Receptor Bitopics	10
Filming the DNA Damaging Mechanisms of AuNP by the Four Dimensions Atomic Force Microscopy (4DAFM) in Molecular Environment	9
Diversity, Equity, and Inclusive Course Design in Pharmacology Education: Strategies, Opportunities and Lessons Learned	9
Behavioral effects of fentanyl in presence or absence of chronic neuropathic pain in male and female rats	9
Downregulation in Connexin43 expression is associated with reduced ferroptosis and enhanced tolerance to myocardial ischemia-reperfusion injury in type 1 diabetic mice	9
Calcium Imaging Alongside Deep Behavior Learning in Fentanyl Vapor Self-Administration	9
Identification and Characterization of Palmitoylation Sites in the Organic Anion Transporting Polypeptide 1B1 (OATP1B1)	9
HNF4A-AS1 Alleviates Ritonavir-induced Liver Injury via HNRNPC-mediated HNF4A Degradation	9
An Elastin-like Polypeptide-fused Peptide Inhibits MMP-2 Activity at nM Concentrations with High Specificity	9
Amlodipine use in Mild Cognitive Impairment reduces the risk of incident dementia in National Alzheimer’s Coordinating Center participants aged ≥55 years from 2014-2019	9
Development of a Cytochrome P450 CYP3A7 Quantitative Structure-Inhibitory Relationship (QSIR) Model to Assess Drug Safety in Neonates	9
Tubulin acetylation attenuates vasorelaxation in a smooth muscle-dependent manner and contributes to hypertension	9
The Modulatory Effects of Citrus Flavonoid Hesperetin on Nrf2 Expression and NF-kB Signaling Pathway in LPS-Activated BV-2 Microglial Cells	9
Pharmacological Modulation of Hsp70 to Selectively Remove Misfolded Neuronal Nitric Oxide Synthase	9
Efficacy of HS-10382 (TERN-701) in tumor xenograft models, a new investigational allosteric ABL1 kinase inhibitor as a potential treatment for CML	9
A positive allosteric modulator of M1 Acetylcholine receptors improves cognitive deficits in male and female APPswe/PSEN1ΔE9 mice via divergent mechanisms	9
Angiotensin-(1-7) and Gut-Bone Marrow Axis in Aging	9
Probing Adropin-Gpr19 Interactions and Signal Transduction	8
Effects of Cannabinoids and a Cannabinoid Extract on Thermal Nociception and Conditioned Behavior	8
Sexual Dimorphism of the Fasting Adipose: Mitigation of Metabolic and Cardiovascular Dysfunction in a Non-Obese Prediabetic Rat Model	8
Investigating Birch Bark Oil Anti-Oxidative Properties in Human Keratinocytes	8
Development and Characterization of Third Generation MDM2 PROTACs for the Treatment of Acute Myeloid Leukemia Utilizing an Achiral Ligand for E3 Ligase Cereblon	8
Redox Partner Adrenodoxin Allosterically Alters the Function of the Human Steroidogenic Cytochrome P450 11B Enzymes	8
Discovery of Developmental Windows of Drug Sensitivity Using High Content Screening of Normal and Pgp-Knockout Sea Urchin Embryos	8
A GPT4-based Patient Simulation to Enhance the Integration of Pharmacology with Clinical Decision Making in a PharmD Program	8
Inhibiting the Cytotoxic Effect of Tubulin Polymerization-Promoting Protein (TPPP/p25α) Induced α-synuclein Aggregates Via 20S Proteasome Enhancement	8
First potent macrocyclic A3 adenosine receptor agonists reveal G-protein and beta-arrestin2 signaling preferences	8
Deferiprone Decreases Labile Iron in Brain and Ameliorates Abnormal Emotional Behavior in Mice with Brain Iron Accumulation	8
Molecular Dynamics Studies for Nirmatrelvir and the Main Protease from Variants of the Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2)	8
Platycodon Grandifloras Reduces Weight Gain and Attenuates Hepatic Steatosis in a Diet-Induced Mouse Model of Obesity	8
A Behavioral Economic Analysis of Polysubstance Use: Studies with Cocaine, Fentanyl, and Cocaine–Fentanyl Mixtures in Sprague-Dawley Rats	8
The Adhesion GPCR GPR114/ADGRG5 is Activated by its Tethered-Peptide-Agonist Following Receptor Fragment Dissociation	8
Investigating Mu-Opioid Receptor Selectivity of Potentiation of Antinociceptive Effects by a Gβγ Inhibitor, Gallein	8
Blockade of selective Gβγ signaling pathway by gallein decreases development of opioid tolerance	8
Presynaptic Regulation of Monoamine Release in the Dorsal Raphe Nucleus by Alpha2-adrenergic Receptors	8
Agonist concentration-dependent conformational changes of formyl peptide receptor 1 contribute to biased signaling in phagocytes	8
β-adrenoceptor-mediated vasodilation is enhanced by acute colchicine-treatment in men with essential hypertension	8
Interactions between Biological Sex and Hormonal Cycles in Stimulant Effects on Motor Behavior	8
Examining the DNA Methylation Profile of Childhood Solid Tumors to Identify Novel Therapeutically Targeted Sites	8
The BDFN-TrkB-KCC2 pathway as a potential treatment target for modulating alcohol consumption	8
Biomarkers of Exposure in Human Proximal Tubular Cells Incubated with Nephrotoxic Environmental Chemicals and Drugs: Altered Metabolic Pathways	8

Big Benefits from Linking Small Antibodies (Nanobodies) to Small Molecule GPCR Ligands	7
Role of β-arrestin-2 in the development of opioid withdrawal in the mouse colon	7
A High Throughput Cell-Based Deubiquitinase Screening Assay	7
Enhancing the Scalability and Therapeutic Window of Taccalonolide-based Chemotherapeutics for the Treatment of Triple-negative Breast Cancers	7
Mechanistic Insights into Xanthohumol-Induced Apoptosis and Cytokine Modulation in Multiple Myeloma with a Focus on Nanoparticle Targeting Strategies	7
RNA-Mediated Regulation of Concentrative Nucleoside Transporter 3	7
Screening of plant extracts in achieving novel strategy in promoting efficacy and combat Cisplatin-induced neurotoxicity	7
Professional Pharmacology and Pharmacy Organization Responses to the Dobbs v. Jackson Supreme Court Ruling	7
Vaporizing Adolescence: Determining the Neurobiological Consequences of Adolescent Vaping on the Prefrontal Cortex, Nucleus Accumbens, and Ventral Tegmental Area	7
Fatty Acid Metabolizing Cytochrome P450 4F11 as a Novel Drug Target for Lung Cancer Treatment	7
IRX4204 enhances gait recovery in mice subjected to experimental autoimmune encephalomyelitis	7
Acute and Subchronic GPR171 Agonism Affects Anxiety and Depression in Female Mice	7
Investigating the targeted anti-TNBC ability of small natural compound	7
Classical Activation of HMC3 Human Brain Microglia by Cyanobacterium Brasilonema sp LPS: Interleukin-6 and Interferon-γ Production	7
Transport Inhibitors to enhance central and peripheral nervous system antidote activity to organophosphate (OP) exposure	7
Can Generative Artificial Intelligence (AI) Reliably Score Open-Ended Questions (OEQs) in the Assessment of Medical Knowledge	7
Visualization of Region-Specific Lipid Alterations in the Mouse Brain in Response to Efavirenz Treatment Using MALDI Mass Spectrometry Imaging	7
β-Arrestin Isoform Conformations are Location-Biased and affect Downstream Signaling of G-protein Coupled Receptors	7
Neurostimulation of the renal nerves as a novel therapeutic option for obstructive sleep apnea treatment	7
The serotonergic psychedelic N,N-Dipropyltryptamine prevents seizures in a mouse model of fragile X syndrome via an apparent non-serotonergic mechanism	7
Structure-activity relationship of G protein-coupled receptor kinase 5 (GRK5) and its mutants	7
Novel Milli-fluidic Human Liver Tissue Chip and Multi-tissue Chip Platform with Continuous Recirculation for Predictive Pharmacokinetic Applications	7
miR-146a; a potential link connecting shear stress-induced activation of the pro-inflammatory and pro-proliferative Osteopontin & TLR-4 pathways	7
Cyclin-dependent kinase 4/6 Inhibitor Abemaciclib and Histone deacetylase Inhibitor Panobinostat Treatment Exerts Metabolic Reprogramming of Pancreatic Cancer Cells	7
The Red Algae Jania rubens Sensitizes Colon Cancer Cells to Doxorubicin Chemotherapy	6
Sex Differences in the Behavioral and Metabolic Effects of Prenatal Stress in Early but not Late Adulthood in Mice	6
Serendipitous Discovery of Novel 5-HT2AR Positive Allosteric Modulators (PAMs) Derived From 5-HT2CR PAM Scaffolds	6
Elucidating the Function of ABCA13 in SHH-Medulloblastoma	6
Characterizing a Mesolimbic Circuit for Opioid Reward	6
Effect of Topical Application of cannabis fixed Oil on Imiquimod-Induced Psoriasis-like Lesions in the Thin Skin of Adult Male Albino rabbits	6
Podocyte injury triggers the formation of intercellular bridges	6
Beneficial Effects of the Direct AMP-Kinase Activator PXL770 in In Vitro and In Vivo Models of X-Linked Adrenoleukodystrophy	6
Effect of Novel Biotherapeutic Elevating Angiopoietin 1 on Progression of Diabetic Nephropathy in Diabetic/Obese Mice	6
Editorial Board	6
Kidney-Targeted Delivery of Prolyl Hydroxylase Domain Protein 2 Small Interfering RNA with Nanoparticles Alleviated Renal Ischemia/Reperfusion Injury	6
Anisodamine Enhances Macrophage M2 Polarization through Suppressing G9a-Mediated Interferon Regulatory Factor 4 Silencing to Alleviate Lipopolysaccharide-Induced Acute Lung Injury	6
Enzyme Kinetics of Benzalkonium Chloride Metabolism in Liver Microsomes	6
Activation of PTH1 receptor using chimeric peptide templated in situ click reaction of nanobody conjugates	6
Paradoxical Effect of Nitric Oxide on GRK2 in the Kidney and Heart: Implications for Sepsis-Associated Kidney Injury	6
Student perceptions of scholarly scientific writing in pharmacology: student generation of collaborative rubrics to score literature reviews in social pharmacology	6
A novel UVA-labile β-adrenergic agonist allows for optical control of subcellular signaling	6
Changes of ACE-2 related-miR-200b-3p expression over time are a predictive factor of long hospitalization for COVID-19: in silico, machine learning and validation analysis	6
Editorial Board	6
SAR340835, a Novel Selective Na+/Ca2+ Exchanger Inhibitor, Improves Cardiac Function and Restores Sympathovagal Balance in Heart Failure	6
Editorial Board	6
Manipulating Pharmacodynamic Efficacy with Agonist + Antagonist Mixtures: In Vitro and In Vivo Studies with Opioids and Cannabinoids	6
Ixazomib Induces Apoptosis and Suppresses Proliferation in Esophageal Squamous Cell Carcinoma through Activation of the c-Myc/NOXA Pathway	6
DR7dA, a Novel Antioxidant Peptide Analog, Demonstrates Antifibrotic Activity in Pulmonary Fibrosis In Vivo and In Vitro	6
Discovery of RNA Editing Inhibitors for Neurological Disorders	6
Investigating Tucatinib Metabolism and CYP3A and CYP2C8 Phenotypes in Human Liver Microsomes from African Americans in vitro	6
Nucleotidases Exhibit Enzymatic Activities Toward the Pharmacologically Active Metabolites of Gemcitabine and Emtricitabine	6
Regulation of GPCR Signaling by Sorting Nexins	6
Location Biased G Protein-Coupled Receptor Signaling Modulates Distinct Spatial Conformations of β-arrestins	6
Preclinical Characterization of LY3209590, a Novel Weekly Basal Insulin Fc-Fusion Protein	6
Cocaine Regulates Antiretroviral Therapy CNS Access Through Pregnane-X Receptor-Mediated Drug Transporter and Metabolizing Enzyme Modulation at the Blood Brain Barrier	6
The Buprenorphine Analogue BU10119 Attenuates Drug-Primed and Stress-Induced Cocaine Reinstatement in Mice	6
Sphingosine 1-Phosphate Receptor Modulator ONO-4641 Regulates Trafficking of T Lymphocytes and Hematopoietic Stem Cells and Alleviates Immune-Mediated Aplastic Anemia in a Mouse Model	6
Enhancing Target Tissue Levels and Diminishing Plasma Clearance of Ionizing Zwitterionic Antidotes in Organophosphate Exposures	6
Table of Contents	6
Comprehensive analysis of CYP2D6 mutations in human cancers	5
Sprague Dawley Rats from Different Vendors Vary in the Modulation of Prepulse Inhibition of Startle (PPI) by Dopamine, Acetylcholine, and Glutamate Drugs	5
Therapeutic Assessment of Combination Therapy with a Neprilysin Inhibitor and Angiotensin Type 1 Receptor Antagonist on Angiotensin II–Induced Atherosclerosis, Abdominal Aortic Aneurysms, and Hyperten	5
Synthesis and Structure-Activity Relationship of SAE-14 Analogs as G-Protein Coupled Receptor 183 Antagonists	5
The Use of Single-Chain Variable Fragments (scFv) to Reverse Cardiopulmonary and Antinociceptive Effects of Fentanyl in Male Mice	5
The Drug Design and Discovery of Novel Enaminone Derivatives as Potential Anti-seizure Agents	5
SERCA Inhibition by Drugs - A Potential Therapeutic Strategy in Ischemia	5
Assessment of an Allosteric Modulator of GIRK 1/2 in Preclinical Models of Cancer-Related Neuropathies to Alleviate Associated Mechanical Allodynia	5
Anesthetic Preconditioning of Traumatic Brain Injury Is Ineffective in a Drosophila Model of Obesity	5
Defining the landscape of cancer vulnerabilities that are engendered by germline genetic variation	5
Elucidating the role of ubiquitination of insulin signaling molecules in HepG2 cells insulin resistance model	5
Protective Effects of Ozanimod in Cisplatin-induced Neuropathic Pain in Mice: Insights from Single-cell Transcriptomic Profiling in Spinal Cord Tissues	5
Antiinflammatory and antioxidative role of pasteurized sauce produced from Capsicum spp and Lycopersicum esculentum against CCl4-induced hepatotoxicity in rats	5
Development of the first vascular-specific KATP channel inhibitor for the treatment of patent ductus arteriosus in newborns	5
Development of Transgenic Mouse Platform for the Detection of Endogenous G protein Activity	5
Knockout of γ-Adducin Promotes NG-Nitro-L-Arginine-Methyl-Ester–Induced Hypertensive Renal Injury	5
Cholesterol Enrichment Alters Compartmentalization of G-Proteins Into Lipid Raft Microdomains	5
A Monoclonal Anti–Calcitonin Gene-Related Peptide Antibody Decreases Stress-Induced Colonic Hypersensitivity	5
Pharmacological Evaluation of Vasant Kusumakar Rasa in High Fat Diet and Streptozotocin-Induced Diabetic Retinopathy in Rats	5
Histone Deacetylase Inhibitor Belinostat Regulates Metabolic Reprogramming in Killing Kras-Mutant Human Lung Cancer Cells	5
Low-Dose Propofol and Salvianolic Acid a Combination Attenuates Myocardial Ischemia/reperfusion-injured Mitochondrial Metabolism via AMPK/HDAC6 Pathway in Diabetes	5
Tricyclic Antidepressants Induce Anti-Inflammatory Signatures in Dorsal Root Ganglia after Prolonged Nerve Injury	5
Contents	5
Effects of Cannabinoid Agonists on Fentanyl-Induced Respiratory Depression	5
5-Aza-4′-thio-2′-deoxycytidine, a New Orally Bioavailable Nontoxic “Best-in-Class”: DNA Methyltransferase 1–Depleting Agent in Clinical Development	5
Hypothalamic nociceptin neurons modulate stress-induced binge eating behaviors	5
Antinociceptive and Discriminative Stimulus Effects of Six Novel Psychoactive Opioid Substances in Male Rats	5
GPR55 Antagonist KLS-13019 Prevents and Reverses Chemotherapy-Induced Peripheral Neuropathy (CIPN) in Rats	5
Optogenetically modulating ventral tegmental area dopamine neuron activity alters dopamine transporter sensitivity to cocaine	5
Regulated Trafficking of GABA Transporters, GAT1 and GAT3, in Response to Methamphetamine	5
Self-Administration of Benzodiazepines in Drug-Naïve Rhesus Monkeys: Role of GABAA Receptor Subtypes	5
Multitarget-Directed Ligands with Soluble Epoxide Hydrolase and Fatty Acid Amide Hydrolase Inhibitory Activities for Treatment of Chronic Pain	5
Redox Partner Adrenodoxin Allosterically Alters the Function of the Human Steroidogenic Cytochrome P450 11B Enzymes	5
A Treatment to Eliminate Respiratory Viral Infections Associated with Asthma Exacerbations	5
Selective Phosphodiesterase 1 Inhibition Ameliorates Vascular Function, Reduces Inflammatory Response, and Lowers Blood Pressure in Aging Animals	5
Development of a Physiologically Based Pharmacokinetic Model for Predicting Midazolam Pharmacokinetics in a Pediatric Population with Obesity	5