Journal of Pathology

Article	Citations
List of Reviewers	130
Issue Information	100
Issue Information	89
Modelling hereditary diffuse gastric cancer initiation using transgenic mouse‐derived gastric organoids and single‐cell sequencing	74
The utility of color normalization for AI‐based diagnosis of hematoxylin and eosin‐stained pathology images	72
Neutrophil extracellular traps drive epithelial–mesenchymal transition of human colon cancer	70
The association between the tumor immune microenvironments and clinical outcome in low‐grade, early‐stage endometrial cancer patients	61
Renal deposition and clearance of recombinant poly‐IgA complexes in a model of IgA nephropathy	61
Empagliflozin protects glomerular endothelial cell architecture in experimental diabetes through the VEGF‐A/caveolin‐1/PV‐1 signaling pathway	58
Evidence for etiologic field changes in tongue distant from tumor in patients with squamous cell carcinoma of the oral tongue	57
Issue Information	53
Cardiac decompensation and promiscuous prenylation of small GTPases in cardiomyocytes in response to local mevalonate pathway disruption†	46
Issue Information	45
Low‐rank fusion convolutional neural network for prediction of remission after stereotactic radiosurgery in patients with acromegaly: a proof‐of‐concept study	44
Polyketide synthase positive Escherichia coli one‐time measurement in stool is not informative of colorectal cancer risk in a screening setting	42
Research autopsy programmes in oncology: shared experience from 14 centres across the world	42
Metformin confers sensitisation to syrosingopine in multiple myeloma cells by metabolic blockage and inhibition of protein synthesis	37
UPK3A+ umbrella cell damage mediated by TLR3–NR2F6 triggers programmed destruction of urothelium in Hunner‐type interstitial cystitis/painful bladder syndrome	37
Prenatal histological, cellular, and molecular anomalies in trisomy 21 lung	37
Pan‐cancer evaluation of tumor‐infiltrating lymphocytes and programmed cell death protein ligand‐1 in metastatic biopsies and matched primary tumors	35
Markers of cognitive resilience and a framework for investigating clinical heterogeneity in ALS†	34
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EHMT1 promotes tumor progression and maintains stemness by regulating ALDH1A1 expression in alveolar rhabdomyosarcoma	34
Decreased HER2 expression in endometrial cancer following anti‐HER2 therapy	32
Breathing in danger: how particulate matter pollution is putting the public at risk of lung cancer†	32

High‐resolution and quantitative spatial analysis reveal intra‐ductal phenotypic and functional diversification in pancreatic cancer	31
Infiltration of NK and plasma cells is associated with a distinct immune subset in non‐small cell lung cancer	31
Concerns about pathology expertise and data quality	30
A new FGF15/19‐mediated gut‐to‐heart axis controls cardiac hypertrophy	30
Deletion ofSox9in the liver leads to hepatic cystogenesis in mice by transcriptionally downregulatingSec63	29
Mutational signature and prognosis in adenocarcinoma of the bladder	28
Molecular characteristics of multifocal esophageal squamous cell carcinomas to discriminate multicentric origin from intramural metastasis	28
B7H3 expression and significance in idiopathic pulmonary fibrosis	26
CXCR4 mediates leukemic cell migration and survival in the testicular microenvironment	26
Jeremy Jass Prize for Research Excellence in Pathology 2021	25
Meflin is a marker of pancreatic stellate cells involved in fibrosis and epithelial regeneration in the pancreas	25
DNA methylation as a new tool for the differential diagnosis between T‐LBL and lymphocyte‐rich thymoma	24
Identification and characterization of primary cilia‐positive salivary gland tumours exhibiting basaloid/myoepithelial differentiation	23
The spectrum and significance of secondary (co‐occurring) genetic alterations in sarcomas: the hallmarks of sarcomagenesis	23
Histone variant H3.3 promotes metastasis in alveolar rhabdomyosarcoma	23
Genomic analysis defines distinct pancreatic and neuronal subtypes of lung carcinoid	23
Collagen VI promotes recovery from colitis by inducing lymphangiogenesis and drainage of inflammatory cells	22
Targeting the TWEAK–Fn14 pathway prevents dysfunction in cardiac calcium handling after acute kidney injury	22
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Insulin‐degrading enzyme: an ally against metabolic and neurodegenerative diseases	22
Defect in degradation of glycogenin‐exposed residual glycogen in lysosomes is the fundamental pathomechanism of Pompe disease	22
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Issue Information	22
Cripto favors chondrocyte hypertrophy via TGF‐β SMAD1/5 signaling during development of osteoarthritis	21
Application of digital pathology‐based advanced analytics of tumour microenvironment organisation to predict prognosis and therapeutic response	21
Initial interactions with the FDA on developing a validation dataset as a medical device development tool	21
Issue Information	20
Air pollution aggravates renal ischaemia–reperfusion‐induced acute kidney injury	20
Progressive stages of dysmetabolism are associated with impaired biological features of human cardiac stromal cells mediated by the oxidative state and autophagy	20
Beyond driver mutations: exploring the landscape of mutational signatures in adenocarcinomas of the bladder†	20
Opposing roles for ADAMTS2 and ADAMTS14 in myofibroblast differentiation and function	19
TRIM28 variants and Wilms' tumour predisposition	19
Hourglass, a rapid analysis framework for heterogeneous bioimaging data, identifies sex disparity in IL‐6/STAT3‐associated immune phenotypes in pancreatic cancer	19
Deletion of mTOR in liver epithelial cells enhances hepatic metastasis of colon cancer	19
SMARCA4‐deficient rhabdoid tumours show intermediate molecular features between SMARCB1‐deficient rhabdoid tumours and small cell carcinomas of the ovary, hypercalcaemic type	18
The genomic trajectory of ovarian high‐grade serous carcinoma can be observed in STIC lesions	18
Methylation profile of imprinted genes provides evidence for teratomatous origin of a subset of mucinous ovarian tumours	18
Novel prognostication biomarker adipophilin reveals a metabolic shift in uveal melanoma and new therapeutic opportunities	18
Human cytomegalovirus infection is associated with increased expression of the lissencephaly gene PAFAH1B1 encoding	18
Optical mesoscopy, machine learning, and computational microscopy enable high information content diagnostic imaging of blood films	18
Myeloma cells regulate miRNA transfer from fibroblast‐derived exosomes by expression of lncRNAs	17
An emerging role for cellular crosstalk in the cancer stem cell niche	17
Deep learning detects genetic alterations in cancer histology generated by adversarial networks	17
‘Know thyself’ – host factors influencing cancer response to immune checkpoint inhibitors	17
RAF1–MEK/ERK pathway‐dependent ARL4C expression promotes ameloblastoma cell proliferation and osteoclast formation	17
Tumor‐immune landscape patterns before and after chemoradiation in resectable esophageal adenocarcinomas	17
Genetic drivers and cells of origin in sarcomagenesis	17
Weakly supervised annotation‐free cancer detection and prediction of genotype in routine histopathology	17
Persistent SARS‐CoV‐2 infection in patients seemingly recovered from COVID‐19	17
A comprehensive luminal breast cancer patient‐derived xenografts (PDX) library to capture tumor heterogeneity and explore the mechanisms of resistance to CDK4/6 inhibitors	16

R‐spondin‐3 is an oncogenic driver of poorly differentiated invasive breast cancer	16
FANCD2 deficiency sensitizes SHH medulloblastoma to radiotherapy via ferroptosis	16
Anti‐VEGFR2 neutralising antibody slows the progression of multistep oral carcinogenesis	16
A multi‐ethnic analysis of immune‐related gene expression signatures in patients with ovarian clear cell carcinoma	16
The Lund taxonomy for bladder cancer classification – from gene expression clustering to cancer cell molecular phenotypes, and back again	16
Integration of peripheral blood‐ and tissue‐based biomarkers of response to immune checkpoint blockade in urothelial carcinoma	16
Integrative analysis of transcriptomic and metabolomic profiles reveals abnormal phosphatidylinositol metabolism in follicles from endometriosis‐associated infertility patients	16
The fifth edition of the WHO classification of mature B‐cell neoplasms: open questions for research	16
Artificial intelligence to identify genetic alterations in conventional histopathology	15
Stroma AReactive Invasion Front Areas (SARIFA) – a new prognostic biomarker in gastric cancer related to tumor‐promoting adipocytes	15
Probing the tumorigenic potential of genetic interactions reconstituted in murine fallopian tube organoids	15
Local factor H production by human choroidal endothelial cells mitigates complement deposition: implications for macular degeneration	15
Advancing drug discovery using the power of the human genome	15
Consensus molecular subtype transition during progression of colorectal cancer	15
Lipophagy and prostate cancer: association with disease aggressiveness and proximity to periprostatic adipose tissue	15
Optical genome mapping identifies a germline retrotransposon insertion in SMARCB1 in two siblings with atypical teratoid rhabdoid tumors	15
Activin B, a new player in kidney fibrosis?†	14
Understanding the implication of autophagy in the activation of hepatic stellate cells in liver fibrosis: are we there yet?	14
Immune‐related gene expression signatures: a step forward in the stratification of patients with ovarian clear cell carcinoma†	14
Indoleamine 2,3‐dioxygenase (IDO)‐1 and IDO‐2 activity and severe course of COVID‐19	14
Ovarian high‐grade serous carcinoma cells with low SMARCA4 expression and high SMARCA2 expression contribute to platinum resistance	14
Escape from senescence: molecular basis and therapeutic ramifications	14
Correction to ‘Autophagy mediates survival of pancreatic tumour‐initiating cells in a hypoxic microenvironment’	14
Adiponectin deficiency promotes endometrial carcinoma pathogenesis and development via activation of mitogen‐activated protein kinase	13
Automated Ki‐67 labeling index assessment in prostate cancer using artificial intelligence and multiplex fluorescence immunohistochemistry	13
‘Experimentally‐induced anti‐myeloperoxidase vasculitis does not require properdin, MASP‐2 or bone marrow‐derived C5’	13
Stress testing deep learning models for prostate cancer detection on biopsies and surgical specimens	13
Presence of Tim3+ and PD‐1+CD8+T cells identifies microsatellite stable colorectal carcinomas with immune exhaustion and di	13
Correction to ‘Quantitative proteomics identifies altered O‐GlcNAcylation of structural, synaptic and memory‐associated proteins in Alzheimer's disease’	13
Clinical significance of pancreatic ductal metaplasia	13
Issue Information	13
‘Splicing predictions, minigene analyses, and ACMG‐AMP clinical classification of 42 germline PALB2 splice‐site variants’	13
Abstracts	13
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Cellular and physical microenvironments regulate the aggressiveness and sunitinib chemosensitivity of clear cell renal cell carcinoma	12
Hedgehog signalling in Foxd1+ embryonic kidney stromal progenitors controls nephron formation via Cxcl12 and Wnt5a	12
Intravenous iron treatment fuels chronic kidney disease‐induced arterial media calcification in rats	12
Tubule‐derived INHBB promotes interstitial fibroblast activation and renal fibrosis	12
Brg1 is required to maintain colorectal cancer stem cells	12
Stromal transdifferentiation drives lipomatosis and induces extensive vascular remodeling in the aging human lymph node	12
Alternative driver pathways in peripheral nerve sheath tumors – including DICER1 and/or KRAS alterations	12
Spatial analysis of microRNA regulation at defined tumor hypoxia levels reveals biological traits of aggressive prostate cancer	12
In high‐grade ovarian carcinoma, platinum‐sensitive tumor recurrence and acquired‐resistance derive from quiescent residual cancer cells that overexpress CRYAB, CEACAM6, and	12
Mucosal melanomas of different anatomic sites share a common global DNA methylation profile with cutaneous melanoma but show location‐dependent patterns of genetic and epigenetic alteration	11
Lack of EGFR catalytic activity in hepatocytes improves liver regeneration following DDC‐induced cholestatic injury by promoting a pro‐restorative inflammatory response	11
Aberrant activation of Rho/ROCK signaling in impaired polarity switching of colorectal micropapillary carcinoma	11
Machine learning models predict the primary sites of head and neck squamous cell carcinoma metastases based on DNA methylation	11
Estradiol promotes cell survival and induces Greb1 expression in granulosa cell tumors of the ovary through an ERα‐dependent mechanism	11
Dual proteotoxic stress accelerates liver injury via activation of p62‐Nrf2	11
The hepatocyte epidermal growth factor receptor (EGFR) pathway regulates the cellular interactome within the liver fibrotic niche	11
Issue Information	10
Issue Information	10
Issue Information	10
Dichotomous role of the serine/threonine kinase MAP4K4 in pancreatic ductal adenocarcinoma onset and metastasis through control of AKT and ERK pathways	10
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Jeremy Jass Prize for Research Excellence in Pathology 2022	10
Manchester Pathology 2021. 13th Joint Meeting of the British Division of the International Academy of Pathology and the Pathological Society of Great Britain & Ireland, 6–8 July 2021	10
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Forward genetics and functional analysis highlight Itga11 as a modulator of murine psoriasiform dermatitis	10
Issue Information	10
Abstracts	10
SWI/SNF‐deficient undifferentiated malignancies: where to draw the line†	10
Integrative multi‐omic analysis reveals neurodevelopmental gene dysregulation in CIC‐knockout and IDH1‐mutant cells	10
Virtual 4th Joint Winter Meeting of the Pathological Society of Great Britain and Ireland and the Royal Society of Medicine 25th – 26th January 2022	10
Issue Information	10
The loss of histone deacetylase 4 in macrophages exacerbates hepatic and adipose tissue inflammation in male but not in female mice with diet‐induced non‐alcoholic steatohepatitis	10
Cell death induced by NLRP3–palmitate axis impairs pulmonary damage tolerance and aggravates immunopathology during obesity‐tuberculosis comorbidity	10
Pseudobudding: ruptured glands do not represent true tumor buds	10
Widespread in situ follicular neoplasia in patients who subsequently developed follicular lymphoma	9
Interaction of the tumor suppressor SMAD4 and WNT signaling in progression to oral squamous cell carcinoma	9
Biological and clinical significance of the YKL‐40/osteopontin–integrin β4–p70S6K axis induced by macrophages in early oesophageal squamous cell carcinoma	9
CDT1 drives replication overlicensing and enhances tumorigenesis in the gut†	9
An overview of mutational and copy number signatures in human cancer	9
Genomic characterization and histologic analysis of uterine leiomyosarcoma arising from leiomyoma with bizarre nuclei	9
Fibrinogen Aα‐chain amyloidosis outbreaks in Japanese squirrels (Sciurus lis): a potential disease model	9
Clinical ApoA‐IV amyloid is associated with fibrillogenic signal sequence	9
CRISPR–Cas9 screening identifies the role of FER as a tumor suppressor	9
FGF21: a promising therapeutic agent for alcoholic cardiomyopathy?†	9
Human scattered tubular cells represent a heterogeneous population of glycolytic dedifferentiated proximal tubule cells	9

Silencing GRHL3 promotes multiple organ distant metastasis of lung squamous cell carcinoma cells by enhancing SOX2 stability via SIRT1	9
Combination of human tau and islet amyloid polypeptide exacerbates metabolic dysfunction in transgenic mice	9
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CD27/CD70 pathway activation in primary cutaneous CD4+ small/medium T‐cell lymphoproliferative disorder	9
Serial genomic analysis of endometrium supports the existence of histologically indistinct endometrial cancer precursors	9
Genomic features of Helicobacter pylori‐naïve diffuse‐type gastric cancer	9
Clinical implications of cell‐of‐origin epigenetic characteristics in non‐functional pancreatic neuroendocrine tumors	8
Tumor‐infiltrating lymphocytes‐based subtypes and genomic characteristics of EBV‐associated lymphoepithelioma‐like carcinoma	8
KAT8/SIRT7‐mediated Fascin‐K41 acetylation/deacetylation regulates tumor metastasis in esophageal squamous cell carcinoma	8
Elucidating the role of the kinase activity of endothelial cell focal adhesion kinase in angiocrine signalling and tumour growth	8
Nondestructive3Dpathology with analysis of nuclear features for prostate cancer risk assessment	8
Detection of circulating tumour DNA after neoadjuvant chemoradiotherapy in patients with locally advanced oesophageal cancer	8
Targeting the β2‐adrenergic receptor increases chemosensitivity in multiple myeloma by induction of apoptosis and modulating cancer cell metabolism	8
Integrating computational pathology and proteomics to address tumor heterogeneity	8
Single‐cell profiling identifies distinct hormonal, immunologic, and inflammatory signatures of endometriosis‐constituting cells	8
Nuclear pCHK1 as a potential biomarker of increased sensitivity to ATR inhibition	8
Computational pathology in cancer diagnosis, prognosis, and prediction – present day and prospects	8
Acquired NF2 mutation confers resistance to TRK inhibition in an ex vivoLMNA::NTRK1‐rearranged soft‐tissue sarcoma cell model	8
The CCL2–CCR2 axis determines whether glomerular endocapillary hypercellularity or wire‐loop lesions develop through glomerular macrophage and neutrophil infiltration in lupus ne	8
Steroid hormone imbalance drives macrophage infiltration and Spp1/osteopontin+ foam cell differentiation in the prostate	8
Mechanisms of carboplatin‐ and paclitaxel‐dependent induction of premature senescence and pro‐cancerogenic conversion of normal peritoneal mesothelium and fibroblasts	8
Deficiency of inflammation‐sensing protein neuropilin‐2 in myeloid‐derived macrophages exacerbates colitis via NF‐κB activation	8
Automated tumor immunophenotyping predicts clinical benefit from anti‐PD‐L1 immunotherapy	8