Journal of Pathology

Article	Citations
Angiotensin‐converting enzyme 2 (ACE2), SARS‐CoV‐2 and the pathophysiology of coronavirus disease 2019 (COVID‐19)	733
The path to a better biomarker: application of a risk management framework for the implementation of PD‐L1 and TILs as immuno‐oncology biomarkers in breast cancer clinical trials and daily practice	137
A streamlined mass spectrometry–based proteomics workflow for large‐scale FFPE tissue analysis	106
TGF‐β as a driver of fibrosis: physiological roles and therapeutic opportunities	100
Molecular pathology of Lynch syndrome	95
YAP signaling induces PIEZO1 to promote oral squamous cell carcinoma cell proliferation	88
COVID‐19: immunopathology, pathophysiological mechanisms, and treatment options	84
Salivary glands are a target for SARS‐CoV‐2: a source for saliva contamination	64
Endometrial carcinoma: molecular subtypes, precursors and the role of pathology in early diagnosis	60
Pathological post‐mortem findings in lungs infected with SARS‐CoV‐2	59
Independent real‐world application of a clinical‐grade automated prostate cancer detection system	55
Genomic analysis of low‐grade serous ovarian carcinoma to identify key drivers and therapeutic vulnerabilities	54
Advances in the molecular classification of pediatric brain tumors: a guide to the galaxy	53
Overexpression of the SARS‐CoV‐2 receptor ACE2 is induced by cigarette smoke in bronchial and alveolar epithelia	53
Synthesis of diagnostic quality cancer pathology images by generative adversarial networks	52
Artificial intelligence to identify genetic alterations in conventional histopathology	50
Heterogenous presence of neutrophil extracellular traps in human solid tumours is partially dependent on IL‐8	49
Weakly supervised annotation‐free cancer detection and prediction of genotype in routine histopathology	48
Identification of glomerular lesions and intrinsic glomerular cell types in kidney diseases via deep learning	44
Histological 3D reconstruction and in vivo lineage tracing of the human endometrium	44
Neutrophil extracellular traps drive epithelial–mesenchymal transition of human colon cancer	43
Chimeric antigen receptor‐modified macrophages trigger systemic anti‐tumour immunity	40
Single‐cell analysis of mouse and human prostate reveals novel fibroblasts with specialized distribution and microenvironment interactions	38
Molecular subtyping reveals immune alterations in IDH wild‐type lower‐grade diffuse glioma	38
Deep learning identifies inflamed fat as a risk factor for lymph node metastasis in early colorectal cancer	37

Immune cell analyses of the tumor microenvironment in prostate cancer highlight infiltrating regulatory T cells and macrophages as adverse prognostic factors	36
Neutrophils expressing lysyl oxidase‐like 4 protein are present in colorectal cancer liver metastases resistant to anti‐angiogenic therapy	35
Oligodendrocyte pathology exceeds axonal pathology in white matter in human amyotrophic lateral sclerosis	35
Prostate cancer patient‐derived organoids: detailed outcome from a prospective cohort of 81 clinical specimens	35
Spontaneously occurring melanoma in animals and their relevance to human melanoma	34
Histone demethylase PHF8 drives neuroendocrine prostate cancer progression by epigenetically upregulating FOXA2	32
Macrophage–stroma interactions in fibrosis: biochemical, biophysical, and cellular perspectives	32
RAF1–MEK/ERK pathway‐dependent ARL4C expression promotes ameloblastoma cell proliferation and osteoclast formation	32
The state of the art for artificial intelligence in lung digital pathology	31
The genetics of mitochondrial disease: dissecting mitochondrial pathology using multi‐omic pipelines	31
Single cell transcriptomes of normal endometrial derived organoids uncover novel cell type markers and cryptic differentiation of primary tumours	31
An emerging role for cellular crosstalk in the cancer stem cell niche	30
Insulin‐degrading enzyme: an ally against metabolic and neurodegenerative diseases	29
Dissecting expression profiles of gastric precancerous lesions and early gastric cancer to explore crucial molecules in intestinal‐type gastric cancer tumorigenesis	29
Understanding the implication of autophagy in the activation of hepatic stellate cells in liver fibrosis: are we there yet?	29
Trop2 is upregulated in the transition to dysplasia in the metaplastic gastric mucosa	29
Microglia/macrophages express alternative proangiogenic factors depending on granulocyte content in human glioblastoma	29
Weakly supervised learning on unannotated H&E‐stained slides predicts BRAF mutation in thyroid cancer with high accuracy	28
The use of Mendelian randomisation to identify causal cancer risk factors: promise and limitations	28
FDXR regulates TP73 tumor suppressor via IRP2 to modulate aging and tumor suppression	28
Machine learning‐based analysis of alveolar and vascular injury in SARS‐CoV‐2 acute respiratory failure	28
Molecular characterization of organoids derived from pancreatic intraductal papillary mucinous neoplasms	28
ZHX2 inhibits SREBP1c‐mediated de novo lipogenesis in hepatocellular carcinoma via miR‐24‐3p	27
Overexpression of chitinase‐3‐like protein 1 is associated with structural recurrence in patients with differentiated thyroid cancer	27
Cancer‐associated fibroblasts in pancreatic cancer: new subtypes, new markers, new targets	27
Expression patterns and prognostic relevance of subtype‐specific transcription factors in surgically resected small‐cell lung cancer: an international multicenter study	27
Genome‐wide mutation analysis in precancerous lesions of endometrial carcinoma	27
5‐Alpha reductase inhibitors induce a prostate luminal to club cell transition in human benign prostatic hyperplasia	26
Persistent SARS‐CoV‐2 infection in patients seemingly recovered from COVID‐19	26
Developing image analysis methods for digital pathology	26
The microbiome(s) and cancer: know thy neighbor(s)	26
Indoleamine 2,3‐dioxygenase (IDO)‐1 and IDO‐2 activity and severe course of COVID‐19	26
Large‐scale analysis of BAP1 expression reveals novel associations with clinical and molecular features of malignant pleural mesothelioma	25
Assessment of a computerized quantitative quality control tool for whole slide images of kidney biopsies	25
T‐cell exhaustion interrelates with immune cytolytic activity to shape the inflamed tumor microenvironment	24
Deep learning detects genetic alterations in cancer histology generated by adversarial networks	23
Optical genome mapping identifies a germline retrotransposon insertion in SMARCB1 in two siblings with atypical teratoid rhabdoid tumors	23
Metabolomics, machine learning and immunohistochemistry to predict succinate dehydrogenase mutational status in phaeochromocytomas and paragangliomas	22
Targeting the KDM4B–AR–c‐Myc axis promotes sensitivity to androgen receptor‐targeted therapy in advanced prostate cancer	21
GPNMB expression identifies TSC1/2/mTOR‐associated and MiT family translocation‐driven renal neoplasms	21
Endothelial to mesenchymal transition during neonatal hyperoxia‐induced pulmonary hypertension	21
A digital score of tumour‐associated stroma infiltrating lymphocytes predicts survival in head and neck squamous cell carcinoma	21
Clinical and research applications of multiplexed immunohistochemistry and in situ hybridization	21
Drivers underpinning the malignant transformation of giant cell tumour of bone	21
A developmental basis for the anatomical diversity of dermis in homeostasis and wound repair	20
Tumour‐suppressive effect of oestrogen receptor β in colorectal cancer patients, colon cancer cells, and a zebrafish model	20
The utility of color normalization for AI‐based diagnosis of hematoxylin and eosin‐stained pathology images	20
H3K27me3 expression and methylation status in histological variants of malignant peripheral nerve sheath tumours	20
CUL4B renders breast cancer cells tamoxifen‐resistant via miR‐32‐5p/ER‐α36 axis	20
Machine learning models predict the primary sites of head and neck squamous cell carcinoma metastases based on DNA methylation	20

Empagliflozin protects glomerular endothelial cell architecture in experimental diabetes through the VEGF‐A/caveolin‐1/PV‐1 signaling pathway	20
SETDB1 promotes gastric carcinogenesis and metastasis via upregulation of CCND1 and MMP9 expression	20
Induced hepatic stellate cell integrin, α8β1, enhances cellular contractility and TGFβ activity in liver fibrosis	20
Inhibition of guanosine monophosphate synthetase (GMPS) blocks glutamine metabolism and prostate cancer growth	19
Malignant melanotic Xp11 neoplasms exhibit a clinicopathologic spectrum and gene expression profiling akin to alveolar soft part sarcoma: a proposal for reclassification	19
Bronchioalveolar stem cells in lung repair, regeneration and disease	19
miRNA‐200c‐3p promotes endothelial to mesenchymal transition and neointimal hyperplasia in artery bypass grafts	19
Comprehensive genetic features of gastric mixed adenoneuroendocrine carcinomas and pure neuroendocrine carcinomas	19
Differential TM4SF5‐mediated SIRT1 modulation and metabolic signaling in nonalcoholic steatohepatitis progression	19
Physical plasma therapy accelerates wound re‐epithelialisation and enhances extracellular matrix formation in cutaneous skin grafts	18
miRNA profiling of biliary intraepithelial neoplasia reveals stepwise tumorigenesis in distal cholangiocarcinoma via the miR‐451a/ATF2 axis	18
The EMT transcription factor ZEB1 blocks osteoblastic differentiation in bone development and osteosarcoma	18
Infiltration of NK and plasma cells is associated with a distinct immune subset in non‐small cell lung cancer	18
Podocytes present antigen to activate specific T cell immune responses in inflammatory renal disease	18
Periostin deficiency reduces diethylnitrosamine‐induced liver cancer in mice by decreasing hepatic stellate cell activation and cancer cell proliferation	17
Characterization of RNF43 frameshift mutations that drive Wnt ligand‐ and R‐spondin‐dependent colon cancer	17
Three‐dimensional analysis of extrahepatic cholangiocarcinoma and tumor budding	17
NLRP3 inflammasome as a key molecular target underlying cognitive resilience in amyotrophic lateral sclerosis	17
Artificial intelligence strategy integrating morphologic and architectural biomarkers provides robust diagnostic accuracy for disease progression in chronic lymphocytic leukemia	17
Cathelicidin‐related antimicrobial peptide alleviates alcoholic liver disease through inhibiting inflammasome activation	17
HPV16 induces penile intraepithelial neoplasia and squamous cell carcinoma in transgenic mice: first mouse model for HPV‐related penile cancer	17
Upregulated expression and function of the α4β1 integrin in multiple myeloma cells resistant to bortezomib	17
ADAM10 mediates ectopic proximal tubule development and renal fibrosis through Notch signalling	17
P2X4 purinergic receptors offer a therapeutic target for aggressive prostate cancer	16
A smooth muscle‐derived, Braf‐driven mouse model of gastrointestinal stromal tumor (GIST): evidence for an alternative GIST cell‐of‐origin	16
Splicing predictions, minigene analyses, and ACMG‐AMP clinical classification of 42 germline PALB2 splice‐site variants	16
TRIM28 variants and Wilms' tumour predisposition	16
Multisystem screening reveals SARS‐CoV‐2 in neurons of the myenteric plexus and in megakaryocytes	16
The protective effect of fibroblast growth factor‐21 in alcoholic cardiomyopathy: a role in protecting cardiac mitochondrial function	16
Periostin‐ and podoplanin‐positive cancer‐associated fibroblast subtypes cooperate to shape the inflamed tumor microenvironment in aggressive pancreatic adenocarcinoma	15
Microenvironmental regulation of tumour immunity and response to immunotherapy	15
Integrated genetic and epigenetic analysis of cancer‐related genes in non‐ampullary duodenal adenomas and intramucosal adenocarcinomas	15
The dysregulation of metabolic pathways and induction of the pentose phosphate pathway in renal ischaemia–reperfusion injury	15
Integrative analysis of the DNA methylome and transcriptome in uterine leiomyoma shows altered regulation of genes involved in metabolism, proliferation, extracellular matrix, and vesicles	15
The foggy world(s) of p63 isoform regulation in normal cells and cancer	15
Validated biomarker assays confirm that ARID1A loss is confounded with MMR deficiency, CD8+ TIL infiltration, and provides no independent prognostic value i	15
Field cancerization in breast cancer	15
Myeloma cells regulate miRNA transfer from fibroblast‐derived exosomes by expression of lncRNAs	15
Multiregional whole‐genome sequencing of hepatocellular carcinoma with nodule‐in‐nodule appearance reveals stepwise cancer evolution	15
c‐Jun acts downstream of PI3K/AKT signaling to mediate the effect of leptin on methionine adenosyltransferase 2B in hepatic stellate cells in vitro a	15
Inflammatory capacity of exosomes released in the early stages of acute pancreatitis predicts the severity of the disease	15
MyD88 in myofibroblasts regulates aerobic glycolysis‐driven hepatocarcinogenesis via ERK‐dependent PKM2 nuclear relocalization and activation	15
Cisd2: a promising new target in Alzheimer's disease†	14
The systemic influence of chronic smoking on skin structure and mechanical function	14
Ferrostatin‐1 modulates dysregulated kidney lipids in acute kidney injury	14
PI3K signalling in chronic obstructive pulmonary disease and opportunities for therapy	14
Feasibility of whole‐genome sequencing‐based tumor diagnostics in routine pathology practice	14
A map of the spatial distribution and tumour‐associated macrophage states in glioblastoma and grade 4 IDH‐mutant astrocytoma	14
Lipophagy and prostate cancer: association with disease aggressiveness and proximity to periprostatic adipose tissue	14
Dystrophin deficiency impairs vascular structure and function in the canine model of Duchenne muscular dystrophy	14
Benign prostatic hyperplasia/obstruction ameliorated using a soluble guanylate cyclase activator	14
BOP1 confers chemoresistance of triple‐negative breast cancer by promoting CBP‐mediated β‐catenin acetylation	14
Deficiency in IκBα in the intestinal epithelium leads to spontaneous inflammation and mediates apoptosis in the gut	14
DSCR1 upregulation enhances dural meningeal lymphatic drainage to attenuate amyloid pathology of Alzheimer's disease	13
Features of increased malignancy in eosinophilic clear cell renal cell carcinoma	13
Organoids in cancer research: a review for pathologist‐scientists	13
Detecting drug resistance in pancreatic cancer organoids guides optimized chemotherapy treatment	13
What do we need to know and understand about p53 to improve its clinical value?	13
Integrative analysis of genomic and transcriptomic data of normal, tumour, and co‐occurring leukoplakia tissue triads drawn from patients with gingivobuccal oral cancer identifies signatures of tumour	13
Presence of Tim3+ and PD‐1+CD8+T cells identifies microsatellite stable colorectal carcinomas with immune exhaustion and di	13
A conditional mouse expressing an activating mutation in NRF2 displays hyperplasia of the upper gastrointestinal tract and decreased white adipose tissue	13
Reciprocal YAP1 loss and INSM1 expression in neuroendocrine prostate cancer	13
Deep learning based on hematoxylin–eosin staining outperforms immunohistochemistry in predicting molecular subtypes of gastric adenocarcinoma	13
Exome sequencing identifies new somatic alterations and mutation patterns of tongue squamous cell carcinoma in a Chinese population	13
Genetic ablation of FASN attenuates the invasive potential of prostate cancer driven by Pten loss	13
Ultrastructure of cell trafficking pathways and coronavirus: how to recognise the wolf amongst the sheep	13
Comparative genomics of primary prostate cancer and paired metastases: insights from 12 molecular case studies	13
Differential mast cell phenotypes in benign versus cancer tissues and prostate cancer oncologic outcomes	13
MIST: multiple instance learning network based on Swin Transformer for whole slide image classification of colorectal adenomas	13
Molecular and functional characterization of urine‐derived podocytes from patients with Alport syndrome	13
Control of neutrophil influx during peritonitis by transcriptional cross‐regulation of chemokine CXCL1 by IL‐17 and IFN‐γ	13
SMARCA4‐deficient rhabdoid tumours show intermediate molecular features between SMARCB1‐deficient rhabdoid tumours and small cell carcinomas of the ovary, hypercalcaemic type	13
Downregulation of 5‐hydroxymethylcytosine is an early event in pancreatic tumorigenesis	12
CDKN1B mutation and copy number variation are associated with tumor aggressiveness in luminal breast cancer	12
An overview of mutational and copy number signatures in human cancer	12
Effect of VEGFC on lymph flow and inflammation‐induced alveolar bone loss	12
Monoallelic deleterious MUTYH germline variants as a driver for tumorigenesis	12
Androgen receptor enhancer amplification in matched patient‐derived xenografts of primary and castrate‐resistant prostate cancer	12
Oncostatin M is overexpressed in NASH‐related hepatocellular carcinoma and promotes cancer cell invasiveness and angiogenesis	12
Gremlin 1 depletion in vivo causes severe enteropathy and bone marrow failure	12

Local factor H production by human choroidal endothelial cells mitigates complement deposition: implications for macular degeneration	12
Mouse‐INtraDuctal (MIND): an in vivo model for studying the underlying mechanisms of DCIS malignancy	12
Multilayer spectrum of intratumoral heterogeneity in basal bladder cancer	12
NEIL3 promotes hepatoma epithelial–mesenchymal transition by activating the BRAF/MEK/ERK/TWIST signaling pathway	12
Advancing drug discovery using the power of the human genome	12
Metabolic tumor constitution is superior to tumor regression grading for evaluating response to neoadjuvant therapy of esophageal adenocarcinoma patients	11
Cripto favors chondrocyte hypertrophy via TGF‐β SMAD1/5 signaling during development of osteoarthritis	11
Modelling hereditary diffuse gastric cancer initiation using transgenic mouse‐derived gastric organoids and single‐cell sequencing	11
Discordant prognosis of mismatch repair deficiency in colorectal and endometrial cancer reflects variation in antitumour immune response and immune escape	11
SMARCB1 loss induces druggable cyclin D1 deficiency via upregulation of MIR17HG in atypical teratoid rhabdoid tumors	11
Stroma AReactive Invasion Front Areas (SARIFA) – a new prognostic biomarker in gastric cancer related to tumor‐promoting adipocytes	11
Downregulation of SUN2 promotes metastasis of colon cancer by activating BDNF/TrkB signalling by interacting with SIRT1	11
In high‐grade ovarian carcinoma, platinum‐sensitive tumor recurrence and acquired‐resistance derive from quiescent residual cancer cells that overexpress CRYAB, CEACAM6, and	11
Tumor‐immune landscape patterns before and after chemoradiation in resectable esophageal adenocarcinomas	11