Journal of Pathology

Article	Citations
TGF‐β as a driver of fibrosis: physiological roles and therapeutic opportunities	130
COVID‐19: immunopathology, pathophysiological mechanisms, and treatment options	100
YAP signaling induces PIEZO1 to promote oral squamous cell carcinoma cell proliferation	100
Independent real‐world application of a clinical‐grade automated prostate cancer detection system	79
Endometrial carcinoma: molecular subtypes, precursors and the role of pathology in early diagnosis	74
Salivary glands are a target for SARS‐CoV‐2: a source for saliva contamination	72
Heterogenous presence of neutrophil extracellular traps in human solid tumours is partially dependent on IL‐8	70
Chimeric antigen receptor‐modified macrophages trigger systemic anti‐tumour immunity	62
Pathological post‐mortem findings in lungs infected with SARS‐CoV‐2	62
Artificial intelligence to identify genetic alterations in conventional histopathology	61
Neutrophil extracellular traps drive epithelial–mesenchymal transition of human colon cancer	58
Weakly supervised annotation‐free cancer detection and prediction of genotype in routine histopathology	57
Single‐cell analysis of mouse and human prostate reveals novel fibroblasts with specialized distribution and microenvironment interactions	54
Deep learning identifies inflamed fat as a risk factor for lymph node metastasis in early colorectal cancer	53
Prostate cancer patient‐derived organoids: detailed outcome from a prospective cohort of 81 clinical specimens	45
Immune cell analyses of the tumor microenvironment in prostate cancer highlight infiltrating regulatory T cells and macrophages as adverse prognostic factors	44
Histone demethylase PHF8 drives neuroendocrine prostate cancer progression by epigenetically upregulating FOXA2	39
Macrophage–stroma interactions in fibrosis: biochemical, biophysical, and cellular perspectives	39
The state of the art for artificial intelligence in lung digital pathology	38
The genetics of mitochondrial disease: dissecting mitochondrial pathology using multi‐omic pipelines	37
Persistent SARS‐CoV‐2 infection in patients seemingly recovered from COVID‐19	37
Cancer‐associated fibroblasts in pancreatic cancer: new subtypes, new markers, new targets	37
RAF1–MEK/ERK pathway‐dependent ARL4C expression promotes ameloblastoma cell proliferation and osteoclast formation	35
Assessment of a computerized quantitative quality control tool for whole slide images of kidney biopsies	34
Understanding the implication of autophagy in the activation of hepatic stellate cells in liver fibrosis: are we there yet?	34

The utility of color normalization for AI‐based diagnosis of hematoxylin and eosin‐stained pathology images	34
Expression patterns and prognostic relevance of subtype‐specific transcription factors in surgically resected small‐cell lung cancer: an international multicenter study	34
An emerging role for cellular crosstalk in the cancer stem cell niche	34
Microglia/macrophages express alternative proangiogenic factors depending on granulocyte content in human glioblastoma	33
Insulin‐degrading enzyme: an ally against metabolic and neurodegenerative diseases	32
GPNMB expression identifies TSC1/2/mTOR‐associated and MiT family translocation‐driven renal neoplasms	32
The microbiome(s) and cancer: know thy neighbor(s)	31
5‐Alpha reductase inhibitors induce a prostate luminal to club cell transition in human benign prostatic hyperplasia	31
Weakly supervised learning on unannotated H&E‐stained slides predicts BRAF mutation in thyroid cancer with high accuracy	30
Genome‐wide mutation analysis in precancerous lesions of endometrial carcinoma	29
Developing image analysis methods for digital pathology	29
Field cancerization in breast cancer	29
Optical genome mapping identifies a germline retrotransposon insertion in SMARCB1 in two siblings with atypical teratoid rhabdoid tumors	28
Machine learning‐based analysis of alveolar and vascular injury inSARS‐CoV‐2 acute respiratory failure	28
Indoleamine 2,3‐dioxygenase (IDO)‐1 and IDO‐2 activity and severe course of COVID‐19	28
Machine learning models predict the primary sites of head and neck squamous cell carcinoma metastases based on DNA methylation	25
A digital score of tumour‐associated stroma infiltrating lymphocytes predicts survival in head and neck squamous cell carcinoma	25
Clinical and research applications of multiplexed immunohistochemistry and in situ hybridization	24
Empagliflozin protects glomerular endothelial cell architecture in experimental diabetes through the VEGF‐A/caveolin‐1/PV‐1 signaling pathway	24
SETDB1 promotes gastric carcinogenesis and metastasis via upregulation of CCND1 and MMP9 expression	23
miRNA‐200c‐3p promotes endothelial to mesenchymal transition and neointimal hyperplasia in artery bypass grafts	23
Induced hepatic stellate cell integrin, α8β1, enhances cellular contractility and TGFβ activity in liver fibrosis	23
Characterization of RNF43 frameshift mutations that drive Wnt ligand‐ and R‐spondin‐dependent colon cancer	23
A developmental basis for the anatomical diversity of dermis in homeostasis and wound repair	23
Inhibition of guanosine monophosphate synthetase (GMPS) blocks glutamine metabolism and prostate cancer growth	22
The EMT transcription factor ZEB1 blocks osteoblastic differentiation in bone development and osteosarcoma	22
Stroma AReactive Invasion Front Areas (SARIFA) – a new prognostic biomarker in gastric cancer related to tumor‐promoting adipocytes	22
Feasibility of whole‐genome sequencing‐based tumor diagnostics in routine pathology practice	22
CUL4B renders breast cancer cells tamoxifen‐resistant via miR‐32‐5p/ER‐α36 axis	22
A map of the spatial distribution and tumour‐associated macrophage states in glioblastoma and grade 4 IDH‐mutant astrocytoma	22
Periostin‐ and podoplanin‐positive cancer‐associated fibroblast subtypes cooperate to shape the inflamed tumor microenvironment in aggressive pancreatic adenocarcinoma	22
MIST: multiple instance learning network based on Swin Transformer for whole slide image classification of colorectal adenomas	22
The protective effect of fibroblast growth factor‐21 in alcoholic cardiomyopathy: a role in protecting cardiac mitochondrial function	22
Infiltration of NK and plasma cells is associated with a distinct immune subset in non‐small cell lung cancer	21
Deep learning detects genetic alterations in cancer histology generated by adversarial networks	21
Artificial intelligence strategy integrating morphologic and architectural biomarkers provides robust diagnostic accuracy for disease progression in chronic lymphocytic leukemia	20
MyD88 in myofibroblasts regulates aerobic glycolysis‐driven hepatocarcinogenesis via ERK‐dependent PKM2 nuclear relocalization and activation	20
DSCR1 upregulation enhances dural meningeal lymphatic drainage to attenuate amyloid pathology of Alzheimer's disease	20
Detecting drug resistance in pancreatic cancer organoids guides optimized chemotherapy treatment	19
Inflammatory capacity of exosomes released in the early stages of acute pancreatitis predicts the severity of the disease	19
Periostin deficiency reduces diethylnitrosamine‐induced liver cancer in mice by decreasing hepatic stellate cell activation and cancer cell proliferation	19
Reciprocal YAP1 loss and INSM1 expression in neuroendocrine prostate cancer	18
P2X4 purinergic receptors offer a therapeutic target for aggressive prostate cancer	18
The dysregulation of metabolic pathways and induction of the pentose phosphate pathway in renal ischaemia–reperfusion injury	18
PI3K signalling in chronic obstructive pulmonary disease and opportunities for therapy	18
Oncostatin M is overexpressed in NASH‐related hepatocellular carcinoma and promotes cancer cell invasiveness and angiogenesis	18
Cancer‐associated fibroblasts potentiate colorectal cancer progression by crosstalk of the IGF2–IGF1R and Hippo–YAP1 signaling pathways	18
NLRP3 inflammasome as a key molecular target underlying cognitive resilience in amyotrophic lateral sclerosis	18
Deep learning based on hematoxylin–eosin staining outperforms immunohistochemistry in predicting molecular subtypes of gastric adenocarcinoma	18
Validated biomarker assays confirm that ARID1A loss is confounded with MMR deficiency, CD8+ TIL infiltration, and provides no independent prognostic value i	18

Comparative genomics of primary prostate cancer and paired metastases: insights from 12 molecular case studies	17
Microenvironmental regulation of tumour immunity and response to immunotherapy	17
Nondestructive3Dpathology with analysis of nuclear features for prostate cancer risk assessment	17
Presence of Tim3+ and PD‐1+CD8+T cells identifies microsatellite stable colorectal carcinomas with immune exhaustion and di	17
Differential mast cell phenotypes in benign versus cancer tissues and prostate cancer oncologic outcomes	17
The foggy world(s) of p63 isoform regulation in normal cells and cancer	17
Lipophagy and prostate cancer: association with disease aggressiveness and proximity to periprostatic adipose tissue	17
Multisystem screening reveals SARS‐CoV‐2 in neurons of the myenteric plexus and in megakaryocytes	17
Extracting structured information from unstructured histopathology reports using generative pre‐trained transformer 4 (GPT‐4)	17
TRIM28 variants and Wilms' tumour predisposition	17
Downregulation of SUN2 promotes metastasis of colon cancer by activating BDNF/TrkB signalling by interacting with SIRT1	16
Dystrophin deficiency impairs vascular structure and function in the canine model of Duchenne muscular dystrophy	16
ST6GAL1‐mediated aberrant sialylation promotes prostate cancer progression	16
BOP1 confers chemoresistance of triple‐negative breast cancer by promoting CBP‐mediated β‐catenin acetylation	16
Integrative analysis of the DNA methylome and transcriptome in uterine leiomyoma shows altered regulation of genes involved in metabolism, proliferation, extracellular matrix, and vesicles	16
Benign prostatic hyperplasia/obstruction ameliorated using a soluble guanylate cyclase activator	16
SMARCA4‐deficient rhabdoid tumours show intermediate molecular features between SMARCB1‐deficient rhabdoid tumours and small cell carcinomas of the ovary, hypercalcaemic type	16
Ferrostatin‐1 modulates dysregulated kidney lipids in acute kidney injury	16
Discordant prognosis of mismatch repair deficiency in colorectal and endometrial cancer reflects variation in antitumour immune response and immune escape	16
Splicing predictions, minigene analyses, and ACMG‐AMP clinical classification of 42 germline PALB2 splice‐site variants	16
Local factor H production by human choroidal endothelial cells mitigates complement deposition: implications for macular degeneration	16
Computational pathology in cancer diagnosis, prognosis, and prediction – present day and prospects	16
Downregulation of HDAC9 by the ketone metabolite β‐hydroxybutyrate suppresses vascular calcification	15
Mucosal melanomas of different anatomic sites share a common global DNA methylation profile with cutaneous melanoma but show location‐dependent patterns of genetic and epigenetic alteration	15
Monoallelic deleterious MUTYH germline variants as a driver for tumorigenesis	15
Genetic ablation of FASN attenuates the invasive potential of prostate cancer driven by Pten loss	15
Extracellular vesicles arising from apoptosis: forms, functions, and applications	15
Advancing drug discovery using the power of the human genome	15
Androgen receptor enhancer amplification in matched patient‐derived xenografts of primary and castrate‐resistant prostate cancer	15
Integrative analysis of genomic and transcriptomic data of normal, tumour, and co‐occurring leukoplakia tissue triads drawn from patients with gingivobuccal oral cancer identifies signatures of tumour	15
An overview of mutational and copy number signatures in human cancer	15
Myeloma cells regulate miRNA transfer from fibroblast‐derived exosomes by expression of lncRNAs	15
Organoids in cancer research: a review for pathologist‐scientists	15
What do we need to know and understand about p53 to improve its clinical value?	14
Mouse‐INtraDuctal (MIND): an in vivo model for studying the underlying mechanisms of DCIS malignancy	14
Circular RNAs: emerging players in brain aging and neurodegenerative diseases	14
Multilayer spectrum of intratumoral heterogeneity in basal bladder cancer	14
Escape from senescence: molecular basis and therapeutic ramifications	14
The early evolutionary landscape of osteosarcoma provides clues for targeted treatment strategies	13
Metabolic tumor constitution is superior to tumor regression grading for evaluating response to neoadjuvant therapy of esophageal adenocarcinoma patients	13
Modelling hereditary diffuse gastric cancer initiation using transgenic mouse‐derived gastric organoids and single‐cell sequencing	13
Tumour budding and poorly differentiated clusters in colon cancer – different manifestations of partial epithelial–mesenchymal transition	13
NEIL3 promotes hepatoma epithelial–mesenchymal transition by activating the BRAF/MEK/ERK/TWIST signaling pathway	13
Disordered farnesoid X receptor signaling is associated with liver carcinogenesis in Abcb11‐deficient mice	13
Downregulation of 5‐hydroxymethylcytosine is an early event in pancreatic tumorigenesis	13
FOXL2 in adult‐type granulosa cell tumour of the ovary: oncogene or tumour suppressor gene?	13
In high‐grade ovarian carcinoma, platinum‐sensitive tumor recurrence and acquired‐resistance derive from quiescent residual cancer cells that overexpress CRYAB, CEACAM6, and	13
Distinct contributions of cathelin‐related antimicrobial peptide (CRAMP) derived from epithelial cells and macrophages to colon mucosal homeostasis	12
NTRK oncogenic fusions are exclusively associated with the serrated neoplasia pathway in the colorectum and begin to occur in sessile serrated lesions	12
CDKN1B mutation and copy number variation are associated with tumor aggressiveness in luminal breast cancer	12
The association between the tumor immune microenvironments and clinical outcome in low‐grade, early‐stage endometrial cancer patients	12
Integrative analysis of transcriptomic and metabolomic profiles reveals abnormal phosphatidylinositol metabolism in follicles from endometriosis‐associated infertility patients	12
Stanniocalcin 1 is a serum biomarker and potential therapeutic target for HBV‐associated liver fibrosis	12
Long‐term treatment of cancer‐prone germline PTEN mutant mice with low‐dose rapamycin extends lifespan and delays tumour development	12
Dual inhibition of the endothelin and angiotensin receptor ameliorates renal and inner ear pathologies in Alport mice	12
Tumor‐immune landscape patterns before and after chemoradiation in resectable esophageal adenocarcinomas	12
A comparison of DNA sequencing and gene expression profiling to assist tissue of origin diagnosis in cancer of unknown primary	12
BCG invokes superior STING‐mediated innate immune response over radiotherapy in a carcinogen murine model of urothelial cancer	12
Estradiol promotes cell survival and induces Greb1 expression in granulosa cell tumors of the ovary through an ERα‐dependent mechanism	12
‘Know thyself’ – host factors influencing cancer response to immune checkpoint inhibitors	12
Artificial intelligence‐based digital scores of stromal tumour‐infiltrating lymphocytes and tumour‐associated stroma predict disease‐specific survival in triple‐negative breast cancer	11
3D hydrogels reveal medulloblastoma subgroup differences and identify extracellular matrix subtypes that predict patient outcome	11
Classification of intestinal T‐cell receptor repertoires using machine learning methods can identify patients with coeliac disease regardless of dietary gluten status	11
Cripto favors chondrocyte hypertrophy via TGF‐β SMAD1/5 signaling during development of osteoarthritis	11
Unleashing the potential of AI for pathology: challenges and recommendations	11
The collagen landscape in cancer: profiling collagens in tumors and in circulation reveals novel markers of cancer‐associated fibroblast subtypes	11
Skin fibroblast functional heterogeneity in health and disease	11
Prenatal histological, cellular, and molecular anomalies in trisomy 21 lung	11
Epithelial Nr5a2 heterozygosity cooperates with mutant Kras in the development of pancreatic cystic lesions	11
Cellular context determines DNA methylation profiles in SWI/SNF‐deficient cancers of the gynecologic tract	11
Characterization of HOXB13 expression patterns in localized and metastatic castration‐resistant prostate cancer	11
Role of MIF1/MIF2/CD74 interactions in bladder cancer	11
Phosphorylation of hTERT at threonine 249 is a novel tumor biomarker of aggressive cancer with poor prognosis in multiple organs	10
Genetic alterations during the neoplastic cascade towards cholangiocarcinoma in primary sclerosing cholangitis	10
Genomic profiling identifies genes and pathways dysregulated by HEY1–NCOA2 fusion and shines a light on mesenchymal chondrosarcoma tumorigenesis	10
Lineage tracing in human tissues	10
Integrating computational pathology and proteomics to address tumor heterogeneity	10
Aberrant activation of Rho/ROCK signaling in impaired polarity switching of colorectal micropapillary carcinoma	10
Optical mesoscopy, machine learning, and computational microscopy enable high information content diagnostic imaging of blood films	10
Interleukin‐33 improves local immunity during Gram‐negative pneumonia by a combined effect on neutrophils and inflammatory monocytes	10

Increased cell stiffness contributes to complement‐mediated injury of choroidal endothelial cells in a monkey model of early age‐related macular degeneration	10
Yes‐associated protein regulates the hepatoprotective effect of vitamin D receptor activation through promoting adaptive bile duct remodeling in cholestatic mice	10
Random forest modelling demonstrates microglial and protein misfolding features to be key phenotypic markers in C9orf72‐ALS	10
The loss of histone deacetylase 4 in macrophages exacerbates hepatic and adipose tissue inflammation in male but not in female mice with diet‐induced non‐alcoholic steatohepatitis	10
Tubule‐derived INHBB promotes interstitial fibroblast activation and renal fibrosis	10
Renal deposition and clearance of recombinant poly‐IgA complexes in a model of IgA nephropathy	10
Glycolysis and de novo fatty acid synthesis cooperatively regulate pathological vascular smooth muscle cell phenotypic switching and neointimal hyperplasia	10
Insights gained in the pathology of lung disease through single‐cell transcriptomics	10
Pitfalls in machine learning‐based assessment of tumor‐infiltrating lymphocytes in breast cancer: A report of the International Immuno‐Oncology Biomarker Working Group on Breast Cancer	10
Clinical implications of cell‐of‐origin epigenetic characteristics in non‐functional pancreatic neuroendocrine tumors	10
Lack of EGFR catalytic activity in hepatocytes improves liver regeneration following DDC‐induced cholestatic injury by promoting a pro‐restorative inflammatory response	10
Adiponectin deficiency promotes endometrial carcinoma pathogenesis and development via activation of mitogen‐activated protein kinase	10