Journal of Pathology

Article	Citations
Issue Information	102
Ovarian high‐grade serous carcinoma cells with low SMARCA4 expression and high SMARCA2 expression contribute to platinum resistance	101
A new FGF15/19‐mediated gut‐to‐heart axis controls cardiac hypertrophy	89
Escape from senescence: molecular basis and therapeutic ramifications	87
Deep learning‐based H&E‐derived risk scores in colorectal cancer: associations with tumour morphology, biology, and predicted drug response	78
Clinical outcomes and immune contexture in SMARCA4 ‐deficient gastric cancer patients	71
Roles of THBS2 + fibroblasts in malignant transformation of colorec	65
High‐resolution and quantitative spatial analysis reveal intra‐ductal phenotypic and functional diversification in pancreatic cancer	63
‘Know thyself’ – host factors influencing cancer response to immune checkpoint inhibitors	63
Novel prognostication biomarker adipophilin reveals a metabolic shift in uveal melanoma and new therapeutic opportunities	62
Intravenous iron treatment fuels chronic kidney disease‐induced arterial media calcification in rats	51
Breathing in danger: how particulate matter pollution is putting the public at risk of lung cancer†	50
Spatial profiling of ANO7 in prostate tissue: links to AR‐signalling‐associated lipid metabolism and inflammation	48
CXCR4 mediates leukemic cell migration and survival in the testicular microenvironment	46
Tissue‐level heterogeneity in FECD : Descemet's membrane phenotypes and association with TCF4	46
Integration of peripheral blood‐ and tissue‐based biomarkers of response to immune checkpoint blockade in urothelial carcinoma	45
Collagen VI promotes recovery from colitis by inducing lymphangiogenesis and drainage of inflammatory cells	42
Author Index	40
The association between the tumor immune microenvironments and clinical outcome in low‐grade, early‐stage endometrial cancer patients	40
Identification of tumour‐infiltrating myeloid subsets associated with overall survival in lung squamous cell carcinoma	40
	40
Platelet C3G protects from liver fibrosis, while enhancing tumor growth through regulation of the immune response	38
CRISPR –Cas9 screening identifies the role of FER as a tumor suppressor	38
	36
Identification of actionable targets using DEPArray ‐based sorting of pure carcinoma and stromal populations from formalin‐fixed paraffin‐embedded ti	35

Human scattered tubular cells represent a heterogeneous population of glycolytic dedifferentiated proximal tubule cells	34
The E2F1–HOXB9/PBX2–CDK6 axis drives gastric tumorigenesis and serves as a therapeutic target in gastric cancer	34
Integrating computational pathology and proteomics to address tumor heterogeneity	33
Silencing GRHL3 promotes multiple organ distant metastasis of lung squamous cell carcinoma cells by enhancing SOX2 stability via SIRT1	32
Genomic features of Helicobacter pylori‐naïve diffuse‐type gastric cancer	32
Pseudobudding: ruptured glands do not represent true tumor buds	30
Field cancerization in breast cancer	30
KMT2D deficiency potentiates antitumor immunity and sensitizes immune checkpoint blockade in urologic cancers	28
Prediction of coexisting invasive carcinoma on ductal carcinoma in situ (DCIS) lesions by mass spectrometry imaging	28
	27
Minigene‐based splicing analysis and ACMG/AMP‐based tentative classification of 56 ATM variants	26
Issue Information	26
On the origin of gastric tumours: analysis of a case with intramucosal gastric carcinoma and oxyntic gland adenoma	26
	26
Genetic and epigenetic alterations in precursor lesions of endometrial endometrioid carcinoma	25
	24
Development of a multi‐scanner facility for data acquisition for digital pathology artificial intelligence	24
Adrenomedullin2 stimulates progression of thyroid cancer in mice and humans under nutrient excess conditions	24
Downregulated BMP –Smad1/5/8 signaling causes emphysema via dysfunction of alveolar type II epithe	24
	24
Primary thyroid B‐cell lymphoma: molecular insights into its clonal evolution and relapse	24
BMP signalling in colorectal cancer: losing the yin to WNTs yang	22
	22
Tumor immune microenvironment alterations associated with progression in human intraductal papillary mucinous neoplasms	22
	22
Somatic loss of ATM is a late event in pancreatic tumorigenesis	22
	22
PIK3CA mutation subtype delineates distinct immune profiles in gastric carcinoma	21
	21
Canonical Kaiso target genes define a functional signature that associates with breast cancer survival and the invasive lobular carcinoma histological type	21
Issue Information	21
Random forest modelling demonstrates microglial and protein misfolding features to be key phenotypic markers in C9orf72 ‐AL	21
	21
Integrating artificial intelligence ( AI ) into colorectal cancer reporting	20
Issue Information	20
Pitfalls in machine learning‐based assessment of tumor‐infiltrating lymphocytes in breast cancer: A report of the International Immuno‐Oncology Biomarker Working Group on Breast Cancer	19
C1GALT1 expression predicts poor survival in osteosarcoma and is crucial for ABCC1 transporter‐mediated doxorubicin re	19
Caspase activation in tumour‐infiltrating lymphocytes is associated with lymph node metastasis in oral squamous cell carcinoma	19
PCDHGC3 hypermethylation as a potential biomarker of intestinal neuroendocrine carcinomas	19
Lineage tracing in human tissues	19
Multiregion exome sequencing indicates a monoclonal origin of esophageal spindle‐cell squamous cell carcinoma	19
Issue Information	19
Increased expression of phosphodiesterase 4 in activated hepatic stellate cells promotes cytoskeleton remodeling and cell migration	19
Transcriptomics and proteomics reveal distinct biology for lymph node metastases and tumour deposits in colorectal cancer	19
Integrated molecular characterization of esophageal basaloid squamous cell carcinoma: a subtype with distinct RNA expression pattern and immune characteristics, but no specific genetic muta	19
Macrophages producing chondroitin sulfate proteoglycan‐4 induce neuro‐cardiac junction impairment in Duchenne muscular dystrophy	18
APC‐related multiple salivary gland lesions: spatial transcriptomic analysis reveals progressive WNT activation	18
Liver insulin‐like growth factor‐1 mediates effects of low‐intensity vibration on wound healing in diabetic mice	18
Issue Information	18
Issue Information	18

DNA methylation patterns are influenced by Pax3 ::	18
Long‐term treatment of cancer‐prone germline PTEN mutant mice with low‐dose rapamycin extends lifespan and delays tumour development	17
	17
Defining the first bona fide cell model for SMARCA4‐deficient, undifferentiated tumor	17
Cell division‐dependent dissemination following E‐cadherin loss underlies initiation of diffuse‐type gastric cancer	17
Issue Information	17
Assessing spatial sequencing and imaging approaches to capture the molecular and pathological heterogeneity of archived cancer tissues	17
Re‐interpreting tumour behaviour and the tumour microenvironment as normal responses to tissue disorganisation	17
Differential involvement of LUBAC‐mediated linear ubiquitination in intestinal epithelial cells and macrophages during intestinal inflammation	16
Fusion with type 2 macrophages induces melanoma cell heterogeneity that potentiates immunological escape from cytotoxic T lymphocytes	16
Mutation profiling in differential diagnosis between TdT ‐positive high‐grade/large B‐cell lymphoma and B‐lymphoblastic leukaemia/lymphoma	16
Issue Information	16
Correction to ‘Dual inhibition of the endothelin and angiotensin receptor ameliorates renal and inner ear pathologies in Alport mice’	16
Issue Information	16
Genetic alterations during the neoplastic cascade towards cholangiocarcinoma in primary sclerosing cholangitis	15
Spasmolytic polypeptide‐expressing metaplasia (SPEM) cell lineages can be an origin of gastric cancer	15
The state of the art for artificial intelligence in lung digital pathology	15
Cdt1 overexpression drives colorectal carcinogenesis through origin overlicensing and DNA damage	15
Divergent evolution of metachronous follicular lymphoma and extranodal marginal zone lymphoma of mucosa‐associated lymphoid tissue from a common precursor	15
Histone deacetylase 6 inhibition attenuates pathological cardiac hypertrophy by promoting autophagy through MAP1LC3B ubiquitination	15
Transcriptomic profiles of myxofibrosarcoma and undifferentiated pleomorphic sarcoma correlate with clinical and genomic features	15
Tracing metastatic spread in pediatric solid tumors using copy number and targeted deep sequencing	14
Issue Information	14
Human colonic organoids for understanding early events of familial adenomatous polyposis pathogenesis	14
Unleashing the potential of AI for pathology: challenges and recommendations	14
Consensus molecular subtype transition during progression of colorectal cancer	14
Issue Information	14
Integrative analysis of transcriptomic and metabolomic profiles reveals abnormal phosphatidylinositol metabolism in follicles from endometriosis‐associated infertility patients	14
Revisionist history uncovers a simplified molecular‐based classification of differentiated thyroid cancer	14
Anti‐CD40L therapy prevents the formation of precursor lesions to gastric B‐cell MALT lymphoma in a mouse model	14
Genomic analysis defines distinct pancreatic and neuronal subtypes of lung carcinoid	14
Issue Information	14
Expanding the clinicopathologic spectrum and genomic landscape of tumors with SMARCA2/4::CREM fusions	14
‘Experimentally‐induced anti‐myeloperoxidase vasculitis does not require properdin, MASP ‐2 or bone marrow‐derived C5	14
PI3 expression predicts recurrence after chemotherapy with DNA‐damaging drugs in gastric cancer	13
The importance of tumor microenvironment modulations in the progression of pancreatic intraductal papillary mucinous neoplasms†	13
Jeremy Jass Prize for Research Excellence in Pathology 2021	13
The spectrum and significance of secondary (co‐occurring) genetic alterations in sarcomas: the hallmarks of sarcomagenesis	13
Metformin confers sensitisation to syrosingopine in multiple myeloma cells by metabolic blockage and inhibition of protein synthesis	13
Evidence for etiologic field changes in tongue distant from tumor in patients with squamous cell carcinoma of the oral tongue	13
UPK3A+ umbrella cell damage mediated by TLR3–NR2F6 triggers programmed destruction of urothelium in Hunner‐type interstitial cystitis/painful bladder syndrome	13
Stress testing deep learning models for prostate cancer detection on biopsies and surgical specimens	13
Issue Information	12
Nuclear pCHK1 as a potential biomarker of increased sensitivity to ATR inhibition	12
Issue Information	12
Computational pathology in cancer diagnosis, prognosis, and prediction – present day and prospects	12
	12
Interaction of the tumor suppressor SMAD4 and WNT signaling in progression to oral squamous cell carcinoma	12
Issue Information	12
CD27 / CD70 pathway activation in primary cutaneous CD4 + small/med	12
Lack of EGFR catalytic activity in hepatocytes improves liver regeneration following DDC‐induced cholestatic injury by promoting a pro‐restorative inflammatory response	12
Contribution of alterations in peritubular capillary density and microcirculation to the progression of tubular injury and kidney fibrosis	12
	12
Abstracts	12
Application of digital pathology‐based advanced analytics of tumour microenvironment organisation to predict prognosis and therapeutic response	12
Tumor‐infiltrating lymphocytes‐based subtypes and genomic characteristics of EBV‐associated lymphoepithelioma‐like carcinoma	12
Clonal dynamics of chronic myelomonocytic leukemia progression: paired‐sample comparison	12
Fibrinogen Aα‐chain amyloidosis outbreaks in Japanese squirrels (Sciurus lis): a potential disease model	12
Enhanced diagnostic potential of CSPG4 in melanoma and nevi: a comparative study with PRAME ,	12
Extracellular vesicles arising from apoptosis: forms, functions, and applications	11
	11
NEIL3 promotes hepatoma epithelial–mesenchymal transition by activating the BRAF/MEK/ERK/TWIST signaling pathway	11
Dual inhibition of the endothelin and angiotensin receptor ameliorates renal and inner ear pathologies in Alport mice	11
Cell state dynamics during early stages of serous endometrial carcinoma	11
Comprehensive splicing analysis of the alternatively spliced CHEK2 exons 8 and 10 reveals three en	11
Disseminated cancer cells detected by immunocytology in lymph nodes of NSCLC patients are highly prognostic and undergo parallel molecular evolution	11
Oronasal mucosal melanoma is defined by two transcriptional subtypes in humans and dogs with implications for diagnosis and therapy	11
Exploring adenoid basal carcinoma to squamous cell carcinoma of the uterine cervix transformation using spatial transcriptomics	11
Super resolution of pathology images with hierarchical feature integration and local image patterns	11
Issue Information	11
A Tc1‐ and Th1‐T‐lymphocyte‐rich tumor microenvironment is a hallmark of MSI colorectal cancer	11
Role of Toll‐like receptor 4 in intravascular hemolysis‐mediated injury	11
Disorganisation of basement membrane zone architecture impairs melanocyte residence in vitiligo	10
The phospholipid flippase ATP9A enhances macropinocytosis to promote nutrient starvation tolerance in hepatocellular carcinoma	10
	10
Downregulation of HDAC9 by the ketone metabolite β‐hydroxybutyrate suppresses vascular calcification	10
Periostin‐IHH feedforward loop promotes hepatocellular carcinoma development by enhancing hepatic fibrosis and tumor cell proliferation	10
Reducing the risks of nuclear war – the role of health professionals	9
TP53 disruptive mutation predicts platinum‐based chemotherapy and PD‐1/PD‐L1 blockade response in urothelial carcinoma	9
Expression patterns and prognostic relevance of subtype‐specific transcription factors in surgically resected small‐cell lung cancer: an international multicenter study	9

Advancing gastric cancer precision medicine with novel genomic screens†	9
Peak density of immature nerve cells occurs with high‐grade dysplasia in intraductal papillary mucinous neoplasms of the pancreas	9
Distinct genomic landscapes in radiation‐associated angiosarcoma compared with other radiation‐associated sarcoma histologies	9
Cancer‐associated fibroblasts potentiate colorectal cancer progression by crosstalk of the IGF2–IGF1R and Hippo–YAP1 signaling pathways	9
	9
Activated immune infiltrates expand opportunities for targeted therapy in p53‐abnormal endometrial carcinoma	9
Functional genomics screening identifies aspartyl‐tRNA synthetase as a novel prognostic marker and a therapeutic target for gastric cancers	9
Utilizing aptamers in targeted protein degradation strategies for disease therapy	9
Elevated NPM1 and FBL expression correlates with prostate cancer aggressiveness and progression	9
Afadin loss induces breast cancer metastasis through destabilisation of E‐cadherin to F‐actin linkage	9
Issue Information	9
Discoidin domain receptor 2 signaling through PIK3C2α in fibroblasts promotes lung fibrosis	9
Chemokine profiling of melanoma–macrophage crosstalk identifies CCL8 and CCL15 as prognostic facto	9
Truncated FOS impairs osteogenic differentiation and induces prostaglandin and NFκB signalling in	9
Issue Information	9
Muramyl dipeptide alleviates estrogen deficiency‐induced osteoporosis through canonical Wnt signaling	9
	9
List of Reviewers	8
Multiomics sequencing and immune microenvironment characteristics define three subtypes of small cell neuroendocrine carcinoma of the cervix	8
DNA ‐hypermethylated human gastric cancer circumvents apoptosis in the absence of TP53	8
Professor Philip J Coates: an appreciation	8
Mucinous cystic neoplasms of the pancreas and liver share a similar DNA methylation profile with mucinous ovarian tumors	8
Issue Information	8
Spatial transcriptomics exploration of the primary neuroblastoma microenvironment in archived FFPE samples unveils novel paracrine interactions	8
Correction to ‘Hourglass, a compass navigating global and regional heterogeneity of pancreatic cancer’	8
Comprehensive molecular characterization of adenoid cystic carcinoma reveals tumor suppressors as novel drivers and prognostic biomarkers	8
Genetic and immune landscape evolution in MMR‐ deficient colorectal cancer	8
	8
Papillary renal cell carcinoma with high‐ ABCC2 shows an immune‐evasive profile associated with favorable response to immunotherapy	8
TGF‐β3 from fibroblasts promotes necrotising sialometaplasia by suppressing salivary gland cell proliferation and inducing squamous metaplasia	8
Mechanisms regulating vascular and lymphatic regeneration in the heart after myocardial infarction	8
Single‐cell transcriptomic analysis reveals that the APP–CD74 axis promotes immunosuppression and progression of testicular tumors	8
List of Reviewers	8
	8
Intestinal overgrowth of Candida albicans exacerbates bleomycin‐induced pulmonary fibrosis in mice with dysbiosis	7
Glomerular basement membrane deposition of collagen α1(III) in Alport glomeruli by mesangial filopodia injures podocytes via aberrant signaling through DDR1 and integr	7
Issue Information	7
Multinodular and vacuolating neuronal tumor: molecular genetics and DNA methylation analysis of 12 cases	7
The immune‐metabolism interactome in efferocytosis: a new paradigm for the central nervous system diseases revealed by single‐cell sequencing analysis	7
Concerns about pathology expertise and data quality	7
Abstracts	7
AI ‐guided histopathology predicts brain metastasis in lung cancer patients	7
Neutrophil extracellular traps aggravate lung injury by inducing pyroptosis of alveolar macrophages	7
A dominant negative Kcnd3 F227del mutation in mice causes spinocerebellar ataxia type 22 (	7
Definitive study shows no association between ARID1A mutation status and clinical outcome in endometriosis‐related ovarian cancers‡	7
Ductal carcinoma in situ develops within clonal fields of mutant cells in morphologically normal ducts	7
A breast cancer PDX collection enriched in luminal (ER+) tumors and young premenopausal patients to identify new therapeutic strategies for high‐risk patients†	7
Spatial analysis of HPV ‐associated cervical intraepithelial neoplastic tissues demonstrate distinct immune signatures associated with cervical cance	7
Alternative driver pathways in peripheral nerve sheath tumors – including DICER1 and/or KRAS alter	7
	7
Initial interactions with the FDA on developing a validation dataset as a medical device development tool	7
Estrogen regulation in the prostate underlies racial disparity in men with benign prostatic hyperplasia	7
STING1 deficiency ameliorates immune‐mediated crescentic glomerulonephritis in mice	7
Issue Information	7
Dysregulated mitochondrial energy metabolism drives the progression of mucosal field effects to invasive bladder cancer	7
Cytoplasmic SIRT1 promotes paclitaxel resistance in ovarian carcinoma through increased formation and survival of polyploid giant cancer cells	7
Unveiling the intriguing relationship: oncogenic KRAS, morphological shifts, and mutational complexity in pancreatic mucinous cystic neoplasms	7
Metamorphoses in pancreatic cancer precursors: the role of simple mucinous cysts †	7
What practicing pathologists and oncologists should know about the new computational pathology‐based companion diagnostic tools	7
Comprehensive clinicopathological, molecular, and methylation analysis of mesenchymal tumors with NTRK	6
Thrombospondin‐1 binds to integrin β3 to inhibit vascular calcification through suppression of NF‐κB pathway	6
Jeremy Jass Prize for Research Excellence in Pathology 2022	6
Persistent SARS‐CoV‐2 infection in patients seemingly recovered from COVID‐19	6
Redefining phenotypic intratumor heterogeneity of pancreatic ductal adenocarcinoma: a bottom‐up approach	6
Phylogenetic analysis of paired breast carcinomas identifies genetic events associated with clonal recurrence and invasive progression	6
Extracellular matrix remodeling as a unique mechanism of expansion of periprostatic adipose tissue: implication for prostate cancer aggressiveness	6
Biological and clinical significance of the YKL‐40/osteopontin–integrin β4–p70S6K axis induced by macrophages in early oesophageal squamous cell carcinoma	6
NMRK2 is an efficient diagnostic indicator for Xp11.2 translocation renal cell carcinoma	6
Issue Information	6
Integrated morphological, immunohistochemical, and genomic profiling identifies uterine leiomyoma patients with hereditary leiomyomatosis and renal cell cancer syndrome: a comprehensive analysis of 25	6
Mining bulk transcriptomic datasets identifies inflammasome activation and antigen presentation as key novel mechanisms of BK polyomavirus‐associated	6
Single‐cell profiling identifies distinct hormonal, immunologic, and inflammatory signatures of endometriosis‐constituting cells	6
Issue Information	6
The Lund taxonomy for bladder cancer classification – from gene expression clustering to cancer cell molecular phenotypes, and back again	6
Transcriptomic profiling reveals the role of Hedgehog signaling as a biomarker and in the pathogenesis of Ménétrier's disease	6
‘Splicing predictions, minigene analyses, and ACMG‐AMP clinical classification of 42 germline PALB	6
Automated tumor immunophenotyping predicts clinical benefit from anti‐PD‐L1 immunotherapy	6
Molecular evidence of a clonal relationship of synchronous/multifocal gastric‐type lesions of the female genital tract	6
	6
Issue Information	6
Nondestructive 3D pathology with analysis of nuclear features for prostate cancer risk assessment	6
Aberrant TERT expression: linking chronic inflammation to hepatocellular carcinoma†	6
Partial‐ EMT cell state correlates with single cell pattern of invasion in head and neck SCC kerat	6
	6
Correction to ‘Quantitative proteomics identifies altered O‐ GlcNAcylation of structural, synaptic and memory‐associated proteins in Alzheimer's dise	6
DNA methylation as a new tool for the differential diagnosis between T‐LBL and lymphocyte‐rich thymoma	6
The significance of PAX5 in Merkel cell carcinoma	6
Issue Information	6
Fibroblast‐derived neuropilin 1 alleviates renal fibrosis progression	6
Issue Information	6
LINE ‐1 hypomethylation characterizes the inflammatory response in coeliac disease associated‐intestinal mucosa and small bowel adenocarcinomas	6
A digital score of peri‐epithelial lymphocytic activity predicts malignant transformation in oral epithelial dysplasia	6
BIRC3 deficiency blocks the ubiquitination and degradation of GOT2 to impede antitumor immune responses in lung squamous cell carcinoma	5
	5
Issue Information	5