Journal of Pathology

Article	Citations
Artificial intelligence to identify genetic alterations in conventional histopathology	97
Escape from senescence: molecular basis and therapeutic ramifications	85
CXCR4 mediates leukemic cell migration and survival in the testicular microenvironment	79
A new FGF15/19‐mediated gut‐to‐heart axis controls cardiac hypertrophy	74
Integration of peripheral blood‐ and tissue‐based biomarkers of response to immune checkpoint blockade in urothelial carcinoma	73
Issue Information	67
Collagen VI promotes recovery from colitis by inducing lymphangiogenesis and drainage of inflammatory cells	66
Spatial profiling of ANO7 in prostate tissue: links to AR‐signalling‐associated lipid metabolism and inflammation	63
Breathing in danger: how particulate matter pollution is putting the public at risk of lung cancer†	60
Ovarian high‐grade serous carcinoma cells with low SMARCA4 expression and high SMARCA2 expression contribute to platinum resistance	58
Novel prognostication biomarker adipophilin reveals a metabolic shift in uveal melanoma and new therapeutic opportunities	56
The association between the tumor immune microenvironments and clinical outcome in low‐grade, early‐stage endometrial cancer patients	52
‘Know thyself’ – host factors influencing cancer response to immune checkpoint inhibitors	51
Intravenous iron treatment fuels chronic kidney disease‐induced arterial media calcification in rats	50
High‐resolution and quantitative spatial analysis reveal intra‐ductal phenotypic and functional diversification in pancreatic cancer	46
Identification of actionable targets using DEPArray ‐based sorting of pure carcinoma and stromal populations from formalin‐fixed paraffin‐embedded ti	45
Presence of Tim3+ and PD‐1+CD8+T cells identifies microsatellite stable colorectal carcinomas with immune exhaustion and di	45
Field cancerization in breast cancer	44
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CRISPR –Cas9 screening identifies the role of FER as a tumor suppressor	41
Silencing GRHL3 promotes multiple organ distant metastasis of lung squamous cell carcinoma cells by enhancing SOX2 stability via SIRT1	40
Identification of tumour‐infiltrating myeloid subsets associated with overall survival in lung squamous cell carcinoma	40
In high‐grade ovarian carcinoma, platinum‐sensitive tumor recurrence and acquired‐resistance derive from quiescent residual cancer cells that overexpress CRYAB, CEACAM6, and	37
The E2F1–HOXB9/PBX2–CDK6 axis drives gastric tumorigenesis and serves as a therapeutic target in gastric cancer	37
Platelet C3G protects from liver fibrosis, while enhancing tumor growth through regulation of the immune response	37

Pseudobudding: ruptured glands do not represent true tumor buds	36
Human scattered tubular cells represent a heterogeneous population of glycolytic dedifferentiated proximal tubule cells	35
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Integrating computational pathology and proteomics to address tumor heterogeneity	33
KMT2D deficiency potentiates antitumor immunity and sensitizes immune checkpoint blockade in urologic cancers	33
Genomic features of Helicobacter pylori‐naïve diffuse‐type gastric cancer	33
Development of a multi‐scanner facility for data acquisition for digital pathology artificial intelligence	32
Issue Information	31
Integrative analysis of genomic and transcriptomic data of normal, tumour, and co‐occurring leukoplakia tissue triads drawn from patients with gingivobuccal oral cancer identifies signatures of tumour	31
Prediction of coexisting invasive carcinoma on ductal carcinoma in situ (DCIS) lesions by mass spectrometry imaging	31
On the origin of gastric tumours: analysis of a case with intramucosal gastric carcinoma and oxyntic gland adenoma	31
Minigene‐based splicing analysis and ACMG/AMP‐based tentative classification of 56 ATM variants	30
Adrenomedullin2 stimulates progression of thyroid cancer in mice and humans under nutrient excess conditions	29
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PCDHGC3 hypermethylation as a potential biomarker of intestinal neuroendocrine carcinomas	27
Downregulated BMP –Smad1/5/8 signaling causes emphysema via dysfunction of alveolar type II epithe	27
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Primary thyroid B‐cell lymphoma: molecular insights into its clonal evolution and relapse	27
Genetic and epigenetic alterations in precursor lesions of endometrial endometrioid carcinoma	27
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Tumor immune microenvironment alterations associated with progression in human intraductal papillary mucinous neoplasms	25
Integrated molecular characterization of esophageal basaloid squamous cell carcinoma: a subtype with distinct RNA expression pattern and immune characteristics, but no specific genetic muta	25
BMP signalling in colorectal cancer: losing the yin to WNTs yang	25
The earliest events in BRAF‐mutant colorectal cancer: exome sequencing of sessile serrated lesions with a tiny focus dysplasia or cancer reveals recurring mutations in two distinct p	24
PIK3CA mutation subtype delineates distinct immune profiles in gastric carcinoma	24
Deep learning based on hematoxylin–eosin staining outperforms immunohistochemistry in predicting molecular subtypes of gastric adenocarcinoma	23
Issue Information	23
Canonical Kaiso target genes define a functional signature that associates with breast cancer survival and the invasive lobular carcinoma histological type	23
Lineage tracing in human tissues	23
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Somatic loss of ATM is a late event in pancreatic tumorigenesis	22
Random forest modelling demonstrates microglial and protein misfolding features to be key phenotypic markers in C9orf72‐ALS	22
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Pitfalls in machine learning‐based assessment of tumor‐infiltrating lymphocytes in breast cancer: A report of the International Immuno‐Oncology Biomarker Working Group on Breast Cancer	22
Copy‐number intratumor heterogeneity increases the risk of relapse in chemotherapy‐naive stage II colon cancer	22
Increased expression of phosphodiesterase 4 in activated hepatic stellate cells promotes cytoskeleton remodeling and cell migration	21
Liver insulin‐like growth factor‐1 mediates effects of low‐intensity vibration on wound healing in diabetic mice	21
Caspase activation in tumour‐infiltrating lymphocytes is associated with lymph node metastasis in oral squamous cell carcinoma	21
Long‐term treatment of cancer‐prone germline PTEN mutant mice with low‐dose rapamycin extends lifespan and delays tumour development	21
Issue Information	21
Transcriptomics and proteomics reveal distinct biology for lymph node metastases and tumour deposits in colorectal cancer	21
Assessing spatial sequencing and imaging approaches to capture the molecular and pathological heterogeneity of archived cancer tissues	20
Multiregion exome sequencing indicates a monoclonal origin of esophageal spindle‐cell squamous cell carcinoma	20
DNA methylation patterns are influenced by Pax3 ::	19
C1GALT1 expression predicts poor survival in osteosarcoma and is crucial for ABCC1 transporter‐mediated doxorubicin re	19
Issue Information	19
Cell division‐dependent dissemination following E‐cadherin loss underlies initiation of diffuse‐type gastric cancer	19
Genetic alterations during the neoplastic cascade towards cholangiocarcinoma in primary sclerosing cholangitis	18

APC‐related multiple salivary gland lesions: spatial transcriptomic analysis reveals progressive WNT activation	18
Issue Information	18
Macrophages producing chondroitin sulfate proteoglycan‐4 induce neuro‐cardiac junction impairment in Duchenne muscular dystrophy	18
The state of the art for artificial intelligence in lung digital pathology	18
Pancancer cytotoxic T‐cell trapping: are neutrophil extracellular traps a viable biomarker for immunotherapy response?†	18
Expanding the clinicopathologic spectrum and genomic landscape of tumors with SMARCA2/4::CREM fusions	18
Mutation profiling in differential diagnosis between TdT‐positive high‐grade/large B‐cell lymphoma and B‐lymphoblastic leukaemia/lymphoma	18
Revisionist history uncovers a simplified molecular‐based classification of differentiated thyroid cancer	18
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Proteomic profiling identifies novel diagnostic biomarkers and molecular subtypes for mucinous tubular and spindle cell carcinoma of the kidney	17
Defining the first bona fide cell model for SMARCA4‐deficient, undifferentiated tumor	17
Spasmolytic polypeptide‐expressing metaplasia (SPEM) cell lineages can be an origin of gastric cancer	17
Issue Information	17
Correction to ‘Dual inhibition of the endothelin and angiotensin receptor ameliorates renal and inner ear pathologies in Alport mice’	17
Re‐interpreting tumour behaviour and the tumour microenvironment as normal responses to tissue disorganisation	17
Differential involvement of LUBAC‐mediated linear ubiquitination in intestinal epithelial cells and macrophages during intestinal inflammation	16
Histone deacetylase 6 inhibition attenuates pathological cardiac hypertrophy by promoting autophagy through MAP1LC3B ubiquitination	16
Cdt1 overexpression drives colorectal carcinogenesis through origin overlicensing and DNA damage	16
Fusion with type 2 macrophages induces melanoma cell heterogeneity that potentiates immunological escape from cytotoxic T lymphocytes	16
Human colonic organoids for understanding early events of familial adenomatous polyposis pathogenesis	16
Unleashing the potential of AI for pathology: challenges and recommendations	16
Divergent evolution of metachronous follicular lymphoma and extranodal marginal zone lymphoma of mucosa‐associated lymphoid tissue from a common precursor	16
Anti‐CD40L therapy prevents the formation of precursor lesions to gastric B‐cell MALT lymphoma in a mouse model	16
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Transcriptomic profiles of myxofibrosarcoma and undifferentiated pleomorphic sarcoma correlate with clinical and genomic features	16
Immune‐related gene expression signatures: a step forward in the stratification of patients with ovarian clear cell carcinoma †	15
RAF1–MEK/ERK pathway‐dependent ARL4C expression promotes ameloblastoma cell proliferation and osteoclast formation	15
UPK3A+ umbrella cell damage mediated by TLR3–NR2F6 triggers programmed destruction of urothelium in Hunner‐type interstitial cystitis/painful bladder syndrome	15
The importance of tumor microenvironment modulations in the progression of pancreatic intraductal papillary mucinous neoplasms†	15
The spectrum and significance of secondary (co‐occurring) genetic alterations in sarcomas: the hallmarks of sarcomagenesis	15
Jeremy Jass Prize for Research Excellence in Pathology 2021	14
Issue Information	14
‘Experimentally‐induced anti‐myeloperoxidase vasculitis does not require properdin, MASP‐2 or bone marrow‐derived C5’	14
Issue Information	14
PI3 expression predicts recurrence after chemotherapy with DNA‐damaging drugs in gastric cancer	14
Metformin confers sensitisation to syrosingopine in multiple myeloma cells by metabolic blockage and inhibition of protein synthesis	14
Application of digital pathology‐based advanced analytics of tumour microenvironment organisation to predict prognosis and therapeutic response	14
Issue Information	14
Evidence for etiologic field changes in tongue distant from tumor in patients with squamous cell carcinoma of the oral tongue	14
Consensus molecular subtype transition during progression of colorectal cancer	14
Stress testing deep learning models for prostate cancer detection on biopsies and surgical specimens	14
Tracing metastatic spread in pediatric solid tumors using copy number and targeted deep sequencing	14
Indoleamine 2,3‐dioxygenase (IDO)‐1 and IDO‐2 activity and severe course of COVID‐19	13
Clinical significance of pancreatic ductal metaplasia	13
Fibrinogen Aα‐chain amyloidosis outbreaks in Japanese squirrels (Sciurus lis): a potential disease model	13
Issue Information	13
Issue Information	13
Local factor H production by human choroidal endothelial cells mitigates complement deposition: implications for macular degeneration	13
Genomic analysis defines distinct pancreatic and neuronal subtypes of lung carcinoid	13
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Enhanced diagnostic potential of CSPG4 in melanoma and nevi: a comparative study with PRAME, CDC7 and Ki67	13
Tumor‐infiltrating lymphocytes‐based subtypes and genomic characteristics of EBV‐associated lymphoepithelioma‐like carcinoma	13
Interaction of the tumor suppressor SMAD4 and WNT signaling in progression to oral squamous cell carcinoma	13
Abstracts	13
Integrative analysis of transcriptomic and metabolomic profiles reveals abnormal phosphatidylinositol metabolism in follicles from endometriosis‐associated infertility patients	13
Lack of EGFR catalytic activity in hepatocytes improves liver regeneration following DDC‐induced cholestatic injury by promoting a pro‐restorative inflammatory response	13
Nuclear pCHK1 as a potential biomarker of increased sensitivity to ATR inhibition	13
Computer‐extracted features of nuclear morphology in hematoxylin and eosin images distinguish stage II and IV colon tumors	12
Disseminated cancer cells detected by immunocytology in lymph nodes of NSCLC patients are highly prognostic and undergo parallel molecular evolution	12
Issue Information	12
Contribution of alterations in peritubular capillary density and microcirculation to the progression of tubular injury and kidney fibrosis	12
Validated biomarker assays confirm that ARID1A loss is confounded with MMR deficiency,	12
Issue Information	12
Computational pathology in cancer diagnosis, prognosis, and prediction – present day and prospects	12
Clonal dynamics of chronic myelomonocytic leukemia progression: paired‐sample comparison	12
Role of Toll‐like receptor 4 in intravascular hemolysis‐mediated injury	12
A Tc1‐ and Th1‐T‐lymphocyte‐rich tumor microenvironment is a hallmark of MSI colorectal cancer	12
CD27 / CD70 pathway activation in primary cutaneous CD4 + small/med	12
Extracellular vesicles arising from apoptosis: forms, functions, and applications	12
Comprehensive splicing analysis of the alternatively spliced CHEK2 exons 8 and 10 reveals three en	11
Dual inhibition of the endothelin and angiotensin receptor ameliorates renal and inner ear pathologies in Alport mice	11
The phospholipid flippase ATP9A enhances macropinocytosis to promote nutrient starvation tolerance in hepatocellular carcinoma	11
Oronasal mucosal melanoma is defined by two transcriptional subtypes in humans and dogs with implications for diagnosis and therapy	11
FOXL2C134W: much ado about something!†	11
Disorganisation of basement membrane zone architecture impairs melanocyte residence in vitiligo	11
Ferrostatin‐1 modulates dysregulated kidney lipids in acute kidney injury	11
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Issue Information	11
Super resolution of pathology images with hierarchical feature integration and local image patterns	10
Downregulation of HDAC9 by the ketone metabolite β‐hydroxybutyrate suppresses vascular calcification	10

Discoidin domain receptor 2 signaling through PIK3C2α in fibroblasts promotes lung fibrosis	10
Distinct genomic landscapes in radiation‐associated angiosarcoma compared with other radiation‐associated sarcoma histologies	10
Cell state dynamics during early stages of serous endometrial carcinoma	10
Reducing the risks of nuclear war – the role of health professionals	10
P2X4 purinergic receptors offer a therapeutic target for aggressive prostate cancer	10
NEIL3 promotes hepatoma epithelial–mesenchymal transition by activating the BRAF/MEK/ERK/TWIST signaling pathway	10
Afadin loss induces breast cancer metastasis through destabilisation of E‐cadherin to F‐actin linkage	10
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Chemokine profiling of melanoma–macrophage crosstalk identifies CCL8 and CCL15 as prognostic facto	9
Cancer‐associated fibroblasts potentiate colorectal cancer progression by crosstalk of the IGF2–IGF1R and Hippo–YAP1 signaling pathways	9
Periostin‐IHH feedforward loop promotes hepatocellular carcinoma development by enhancing hepatic fibrosis and tumor cell proliferation	9
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Issue Information	9
Spatial transcriptomics exploration of the primary neuroblastoma microenvironment in archived FFPE samples unveils novel paracrine interactions	9
Muramyl dipeptide alleviates estrogen deficiency‐induced osteoporosis through canonical Wnt signaling	9
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Homozygous WASHC4 variant in two sisters causes a syndromic phenotype defined by dysmorphisms, intellectual disability, profound developmental disorder, and skeletal muscle involveme	9
Activated immune infiltrates expand opportunities for targeted therapy in p53‐abnormal endometrial carcinoma	9
Oncostatin M is overexpressed in NASH‐related hepatocellular carcinoma and promotes cancer cell invasiveness and angiogenesis	9
TP53 disruptive mutation predicts platinum‐based chemotherapy and PD‐1/PD‐L1 blockade response in urothelial carcinoma	9
Peak density of immature nerve cells occurs with high‐grade dysplasia in intraductal papillary mucinous neoplasms of the pancreas	9
Unravelling the tumour genome: The evolutionary and clinical impacts of structural variants in tumourigenesis	9
Elevated NPM1 and FBL expression correlates with prostate cancer aggressiveness and progression	9
Mucinous cystic neoplasms of the pancreas and liver share a similar DNA methylation profile with mucinous ovarian tumors	8
Reconstructing the epidermal proteolytic cascades in health and disease	8
Multiomics sequencing and immune microenvironment characteristics define three subtypes of small cell neuroendocrine carcinoma of the cervix	8
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A dominant negative Kcnd3 F227del mutation in mice causes spinocerebellar ataxia type 22 (	8
Genetic and immune landscape evolution in MMR‐ deficient colorectal cancer	8
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Multisystem screening reveals SARS‐CoV‐2 in neurons of the myenteric plexus and in megakaryocytes	8
List of Reviewers	8
Functional genomics screening identifies aspartyl‐tRNA synthetase as a novel prognostic marker and a therapeutic target for gastric cancers	8
TGF‐β3 from fibroblasts promotes necrotising sialometaplasia by suppressing salivary gland cell proliferation and inducing squamous metaplasia	8
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Dysregulated mitochondrial energy metabolism drives the progression of mucosal field effects to invasive bladder cancer	8
Comprehensive molecular characterization of adenoid cystic carcinoma reveals tumor suppressors as novel drivers and prognostic biomarkers	8
BCG invokes superior STING‐mediated innate immune response over radiotherapy in a carcinogen murine model of urothelial cancer	8
Correction to ‘Hourglass, a compass navigating global and regional heterogeneity of pancreatic cancer’	8
Issue Information	8
Advancing gastric cancer precision medicine with novel genomic screens†	8
Issue Information	8
Utilizing aptamers in targeted protein degradation strategies for disease therapy	8
Expression patterns and prognostic relevance of subtype‐specific transcription factors in surgically resected small‐cell lung cancer: an international multicenter study	8
Mechanisms regulating vascular and lymphatic regeneration in the heart after myocardial infarction	8
DNA‐hypermethylated human gastric cancer circumvents apoptosis in the absence of TP53 mutation	7
A breast cancer PDX collection enriched in luminal (ER+) tumors and young premenopausal patients to identify new therapeutic strategies for high‐risk patients†	7
Cytoplasmic SIRT1 promotes paclitaxel resistance in ovarian carcinoma through increased formation and survival of polyploid giant cancer cells	7
Intestinal overgrowth of Candida albicans exacerbates bleomycin‐induced pulmonary fibrosis in mice with dysbiosis	7
Metamorphoses in pancreatic cancer precursors: the role of simple mucinous cysts †	7
Ductal carcinoma in situ develops within clonal fields of mutant cells in morphologically normal ducts	7
Issue Information	7
Definitive study shows no association between ARID1A mutation status and clinical outcome in endometriosis‐related ovarian cancers‡	7
Glomerular basement membrane deposition of collagen α1(III) in Alport glomeruli by mesangial filopodia injures podocytes via aberrant signaling through DDR1 and integr	7
STING1 deficiency ameliorates immune‐mediated crescentic glomerulonephritis in mice	7
Phylogenetic analysis of paired breast carcinomas identifies genetic events associated with clonal recurrence and invasive progression	7
AI ‐guided histopathology predicts brain metastasis in lung cancer patients	7
Single‐cell transcriptomic analysis reveals that the APP–CD74 axis promotes immunosuppression and progression of testicular tumors	7
Issue Information	7
Mitochondria govern histone acetylation in colorectal cancer	7
Tumor‐immune landscape patterns before and after chemoradiation in resectable esophageal adenocarcinomas	7
Discordant prognosis of mismatch repair deficiency in colorectal and endometrial cancer reflects variation in antitumour immune response and immune escape	7
Monoallelic deleterious MUTYH germline variants as a driver for tumorigenesis	7
Alternative driver pathways in peripheral nerve sheath tumors – including DICER1 and/or KRAS alter	6
The utility of color normalization for AI‐based diagnosis of hematoxylin and eosin‐stained pathology images	6
Integrative multi‐omic analysis reveals neurodevelopmental gene dysregulation in CIC‐knockout and IDH1‐mutant cells	6
Automated tumor immunophenotyping predicts clinical benefit from anti‐PD‐L1 immunotherapy	6
DNA methylation as a new tool for the differential diagnosis between T‐LBL and lymphocyte‐rich thymoma	6
Abstracts	6
The Lund taxonomy for bladder cancer classification – from gene expression clustering to cancer cell molecular phenotypes, and back again	6
Persistent SARS‐CoV‐2 infection in patients seemingly recovered from COVID‐19	6
Concerns about pathology expertise and data quality	6
Single‐cell profiling identifies distinct hormonal, immunologic, and inflammatory signatures of endometriosis‐constituting cells	6
Partial‐EMT cell state correlates with single cell pattern of invasion in head and neck SCC keratinocytes	6
Initial interactions with the FDA on developing a validation dataset as a medical device development tool	6
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Correction to ‘Quantitative proteomics identifies altered O‐GlcNAcylation of structural, synaptic and memory‐associated proteins in Alzheimer's disease’	6
‘Splicing predictions, minigene analyses, and ACMG‐AMP clinical classification of 42 germline PALB2 splice‐site variants’	6
The significance of PAX5 in Merkel cell carcinoma	6
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A digital score of peri‐epithelial lymphocytic activity predicts malignant transformation in oral epithelial dysplasia	6
Unveiling the intriguing relationship: oncogenic KRAS, morphological shifts, and mutational complexity in pancreatic mucinous cystic neoplasms	6
Cardiac decompensation and promiscuous prenylation of small GTPases in cardiomyocytes in response to local mevalonate pathway disruption†	6
Thrombospondin‐1 binds to integrin β3 to inhibit vascular calcification through suppression of NF‐κB pathway	6
Redefining phenotypic intratumor heterogeneity of pancreatic ductal adenocarcinoma: a bottom‐up approach	6
Cancer‐associated fibroblast heterogeneity in chordoma†	5
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Genetic context of oncogenic drivers dictates vascular sarcoma development in aP2‐Cre mice	5
Issue Information	5
Optical genome mapping identifies a novel pediatric embryonal tumor with a ZNF532::NUTM1 fusion	5
Multiomic spatial atlas shows deleted in malignant brain tumors 1 (DMBT1) glycoprotein is lost in colonic dysplasia	5
Issue Information	5
Issue Information	5