Journal of Pathology

Article	Citations
Intravenous iron treatment fuels chronic kidney disease‐induced arterial media calcification in rats	93
High‐resolution and quantitative spatial analysis reveal intra‐ductal phenotypic and functional diversification in pancreatic cancer	81
Breathing in danger: how particulate matter pollution is putting the public at risk of lung cancer†	72
Novel prognostication biomarker adipophilin reveals a metabolic shift in uveal melanoma and new therapeutic opportunities	69
CXCR4 mediates leukemic cell migration and survival in the testicular microenvironment	68
The association between the tumor immune microenvironments and clinical outcome in low‐grade, early‐stage endometrial cancer patients	66
Issue Information	64
Ovarian high‐grade serous carcinoma cells with low SMARCA4 expression and high SMARCA2 expression contribute to platinum resistance	60
Spatial profiling of ANO7 in prostate tissue: links to AR‐signalling‐associated lipid metabolism and inflammation	57
A new FGF15/19‐mediated gut‐to‐heart axis controls cardiac hypertrophy	56
Collagen VI promotes recovery from colitis by inducing lymphangiogenesis and drainage of inflammatory cells	53
Artificial intelligence to identify genetic alterations in conventional histopathology	51
‘Know thyself’ – host factors influencing cancer response to immune checkpoint inhibitors	50
Presence of Tim3+ and PD‐1+CD8+T cells identifies microsatellite stable colorectal carcinomas with immune exhaustion and di	50
Integration of peripheral blood‐ and tissue‐based biomarkers of response to immune checkpoint blockade in urothelial carcinoma	48
Escape from senescence: molecular basis and therapeutic ramifications	46
Integrating computational pathology and proteomics to address tumor heterogeneity	43
CRISPR–Cas9 screening identifies the role of FER as a tumor suppressor	43
Platelet C3G protects from liver fibrosis, while enhancing tumor growth through regulation of the immune response	42
Identification of tumour‐infiltrating myeloid subsets associated with overall survival in lung squamous cell carcinoma	42
The E2F1–HOXB9/PBX2–CDK6 axis drives gastric tumorigenesis and serves as a therapeutic target in gastric cancer	38
Pseudobudding: ruptured glands do not represent true tumor buds	38
Human scattered tubular cells represent a heterogeneous population of glycolytic dedifferentiated proximal tubule cells	38
In high‐grade ovarian carcinoma, platinum‐sensitive tumor recurrence and acquired‐resistance derive from quiescent residual cancer cells that overexpress CRYAB, CEACAM6, and	35
Silencing GRHL3 promotes multiple organ distant metastasis of lung squamous cell carcinoma cells by enhancing SOX2 stability via SIRT1	35

Genomic features of Helicobacter pylori‐naïve diffuse‐type gastric cancer	34
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Field cancerization in breast cancer	33
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Adrenomedullin2 stimulates progression of thyroid cancer in mice and humans under nutrient excess conditions	32
Prediction of coexisting invasive carcinoma on ductal carcinoma in situ (DCIS) lesions by mass spectrometry imaging	32
Integrative analysis of genomic and transcriptomic data of normal, tumour, and co‐occurring leukoplakia tissue triads drawn from patients with gingivobuccal oral cancer identifies signatures of tumour	31
Development of a multi‐scanner facility for data acquisition for digital pathology artificial intelligence	31
Minigene‐based splicing analysis and ACMG/AMP‐based tentative classification of 56 ATM variants	31
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Issue Information	30
On the origin of gastric tumours: analysis of a case with intramucosal gastric carcinoma and oxyntic gland adenoma	29
Downregulated BMP–Smad1/5/8 signaling causes emphysema via dysfunction of alveolar type II epithelial cells	29
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Genetic and epigenetic alterations in precursor lesions of endometrial endometrioid carcinoma	28
Primary thyroid B‐cell lymphoma: molecular insights into its clonal evolution and relapse	28
Issue Information	27
Integrated molecular characterization of esophageal basaloid squamous cell carcinoma: a subtype with distinct RNA expression pattern and immune characteristics, but no specific genetic muta	26
The earliest events in BRAF‐mutant colorectal cancer: exome sequencing of sessile serrated lesions with a tiny focus dysplasia or cancer reveals recurring mutations in two distinct p	26
Tumor immune microenvironment alterations associated with progression in human intraductal papillary mucinous neoplasms	26
PCDHGC3 hypermethylation as a potential biomarker of intestinal neuroendocrine carcinomas	26
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Transcriptomics and proteomics reveal distinct biology for lymph node metastases and tumour deposits in colorectal cancer	25
Random forest modelling demonstrates microglial and protein misfolding features to be key phenotypic markers in C9orf72‐ALS	25
BMP signalling in colorectal cancer: losing the yin to WNTs yang	25
Copy‐number intratumor heterogeneity increases the risk of relapse in chemotherapy‐naive stage II colon cancer	25
Lineage tracing in human tissues	25
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PIK3CA mutation subtype delineates distinct immune profiles in gastric carcinoma	24
Somatic loss ofATMis a late event in pancreatic tumorigenesis	24
Deep learning based on hematoxylin–eosin staining outperforms immunohistochemistry in predicting molecular subtypes of gastric adenocarcinoma	23
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Canonical Kaiso target genes define a functional signature that associates with breast cancer survival and the invasive lobular carcinoma histological type	23
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Pitfalls in machine learning‐based assessment of tumor‐infiltrating lymphocytes in breast cancer: A report of the International Immuno‐Oncology Biomarker Working Group on Breast Cancer	22
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Increased expression of phosphodiesterase 4 in activated hepatic stellate cells promotes cytoskeleton remodeling and cell migration	22
Liver insulin‐like growth factor‐1 mediates effects of low‐intensity vibration on wound healing in diabetic mice	21
Assessing spatial sequencing and imaging approaches to capture the molecular and pathological heterogeneity of archived cancer tissues	21
Issue Information	21
Multiregion exome sequencing indicates a monoclonal origin of esophageal spindle‐cell squamous cell carcinoma	21
Issue Information	21
C1GALT1 expression predicts poor survival in osteosarcoma and is crucial for ABCC1 transporter‐mediated doxorubicin resistance	20
Long‐term treatment of cancer‐prone germline PTEN mutant mice with low‐dose rapamycin extends lifespan and delays tumour development	20
APC‐related multiple salivary gland lesions: spatial transcriptomic analysis reveals progressive WNT activation	20
Macrophages producing chondroitin sulfate proteoglycan‐4 induce neuro‐cardiac junction impairment in Duchenne muscular dystrophy	20
DNA methylation patterns are influenced by Pax3::Foxo1 expression and developmental lineage in rhabdomyosarcoma tumours forming in genetically engineered	20
Cell division‐dependent dissemination following E‐cadherin loss underlies initiation of diffuse‐type gastric cancer	20
Caspase activation in tumour‐infiltrating lymphocytes is associated with lymph node metastasis in oral squamous cell carcinoma	20
Issue Information	19

Expanding the clinicopathologic spectrum and genomic landscape of tumors with SMARCA2/4::CREM fusions	19
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Correction to ‘Dual inhibition of the endothelin and angiotensin receptor ameliorates renal and inner ear pathologies in Alport mice’	19
Issue Information	19
Cdt1 overexpression drives colorectal carcinogenesis through origin overlicensing and DNA damage	18
Pancancer cytotoxic T‐cell trapping: are neutrophil extracellular traps a viable biomarker for immunotherapy response?†	18
Revisionist history uncovers a simplified molecular‐based classification of differentiated thyroid cancer	18
Proteomic profiling identifies novel diagnostic biomarkers and molecular subtypes for mucinous tubular and spindle cell carcinoma of the kidney	18
Anti‐CD40L therapy prevents the formation of precursor lesions to gastric B‐cell MALT lymphoma in a mouse model	18
Fusion with type 2 macrophages induces melanoma cell heterogeneity that potentiates immunological escape from cytotoxic T lymphocytes	18
Genetic alterations during the neoplastic cascade towards cholangiocarcinoma in primary sclerosing cholangitis	17
Re‐interpreting tumour behaviour and the tumour microenvironment as normal responses to tissue disorganisation	17
Defining the first bona fide cell model for SMARCA4‐deficient, undifferentiated tumor	17
Spasmolytic polypeptide‐expressing metaplasia (SPEM) cell lineages can be an origin of gastric cancer	17
Differential involvement of LUBAC‐mediated linear ubiquitination in intestinal epithelial cells and macrophages during intestinal inflammation	17
Divergent evolution of metachronous follicular lymphoma and extranodal marginal zone lymphoma of mucosa‐associated lymphoid tissue from a common precursor	17
Histone deacetylase 6 inhibition attenuates pathological cardiac hypertrophy by promoting autophagy through MAP1LC3B ubiquitination	17
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Human colonic organoids for understanding early events of familial adenomatous polyposis pathogenesis	17
The state of the art for artificial intelligence in lung digital pathology	16
The importance of tumor microenvironment modulations in the progression of pancreatic intraductal papillary mucinous neoplasms†	16
Unleashing the potential of AI for pathology: challenges and recommendations	16
Issue Information	16
Transcriptomic profiles of myxofibrosarcoma and undifferentiated pleomorphic sarcoma correlate with clinical and genomic features	16
Jeremy Jass Prize for Research Excellence in Pathology 2021	16
Consensus molecular subtype transition during progression of colorectal cancer	15
Genomic analysis defines distinct pancreatic and neuronal subtypes of lung carcinoid	15
‘Experimentally‐induced anti‐myeloperoxidase vasculitis does not require properdin, MASP‐2 or bone marrow‐derived C5’	15
Immune‐related gene expression signatures: a step forward in the stratification of patients with ovarian clear cell carcinoma†	15
Local factor H production by human choroidal endothelial cells mitigates complement deposition: implications for macular degeneration	14
The spectrum and significance of secondary (co‐occurring) genetic alterations in sarcomas: the hallmarks of sarcomagenesis	14
Stress testing deep learning models for prostate cancer detection on biopsies and surgical specimens	14
Issue Information	14
Nuclear pCHK1 as a potential biomarker of increased sensitivity to ATR inhibition	14
Issue Information	14
Tumor‐infiltrating lymphocytes‐based subtypes and genomic characteristics of EBV‐associated lymphoepithelioma‐like carcinoma	14
PI3 expression predicts recurrence after chemotherapy with DNA‐damaging drugs in gastric cancer	14
Evidence for etiologic field changes in tongue distant from tumor in patients with squamous cell carcinoma of the oral tongue	14
Clinical significance of pancreatic ductal metaplasia	14
Application of digital pathology‐based advanced analytics of tumour microenvironment organisation to predict prognosis and therapeutic response	14
Issue Information	14
Issue Information	14
Integrative analysis of transcriptomic and metabolomic profiles reveals abnormal phosphatidylinositol metabolism in follicles from endometriosis‐associated infertility patients	14
Indoleamine 2,3‐dioxygenase (IDO)‐1 and IDO‐2 activity and severe course of COVID‐19	14
Metformin confers sensitisation to syrosingopine in multiple myeloma cells by metabolic blockage and inhibition of protein synthesis	14
RAF1–MEK/ERK pathway‐dependent ARL4C expression promotes ameloblastoma cell proliferation and osteoclast formation	14
UPK3A+ umbrella cell damage mediated by TLR3–NR2F6 triggers programmed destruction of urothelium in Hunner‐type interstitial cystitis/painful bladder syndrome	14
Abstracts	14
Contribution of alterations in peritubular capillary density and microcirculation to the progression of tubular injury and kidney fibrosis	13
Extracellular vesicles arising from apoptosis: forms, functions, and applications	13
Interaction of the tumor suppressor SMAD4 and WNT signaling in progression to oral squamous cell carcinoma	13
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Lack of EGFR catalytic activity in hepatocytes improves liver regeneration following DDC‐induced cholestatic injury by promoting a pro‐restorative inflammatory response	13
Fibrinogen Aα‐chain amyloidosis outbreaks in Japanese squirrels (Sciurus lis): a potential disease model	13
CD27/CD70 pathway activation in primary cutaneous CD4+ small/medium T‐cell lymphoproliferative disorder	13
A Tc1‐ and Th1‐T‐lymphocyte‐rich tumor microenvironment is a hallmark of MSI colorectal cancer	12
Disseminated cancer cells detected by immunocytology in lymph nodes of NSCLC patients are highly prognostic and undergo parallel molecular evolution	12
Validated biomarker assays confirm that ARID1A loss is confounded with MMR deficiency, CD8+ TIL infiltration, and provides no independent prognostic value i	12
Enhanced diagnostic potential of CSPG4 in melanoma and nevi: a comparative study with PRAME, CDC7 and Ki67	12
Computational pathology in cancer diagnosis, prognosis, and prediction – present day and prospects	12
Computer‐extracted features of nuclear morphology in hematoxylin and eosin images distinguish stage II and IV colon tumors	12
NEIL3 promotes hepatoma epithelial–mesenchymal transition by activating the BRAF/MEK/ERK/TWIST signaling pathway	12
Clonal dynamics of chronic myelomonocytic leukemia progression: paired‐sample comparison	12
Issue Information	12
Oronasal mucosal melanoma is defined by two transcriptional subtypes in humans and dogs with implications for diagnosis and therapy	12
Issue Information	12
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Disordered farnesoid X receptor signaling is associated with liver carcinogenesis in Abcb11‐deficient mice	12
Molecular genetic evidence supporting diverse histogenic origins of germ cell tumors	11
Ferrostatin‐1 modulates dysregulated kidney lipids in acute kidney injury	11
The phospholipid flippase ATP9A enhances macropinocytosis to promote nutrient starvation tolerance in hepatocellular carcinoma	11
Issue Information	11
FOXL2 in adult‐type granulosa cell tumour of the ovary: oncogene or tumour suppressor gene?	11
Disorganisation of basement membrane zone architecture impairs melanocyte residence in vitiligo	11
Dual inhibition of the endothelin and angiotensin receptor ameliorates renal and inner ear pathologies in Alport mice	11
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Role of Toll‐like receptor 4 in intravascular hemolysis‐mediated injury	11
FOXL2C134W: much ado about something!†	11
Comprehensive splicing analysis of the alternatively spliced CHEK2 exons 8 and 10 reveals three enhancer/silencer‐rich regions and 38 spliceogenic variants	11
Downregulation of HDAC9 by the ketone metabolite β‐hydroxybutyrate suppresses vascular calcification	11

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Muramyl dipeptide alleviates estrogen deficiency‐induced osteoporosis through canonical Wnt signaling	10
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Oncostatin M is overexpressed in NASH‐related hepatocellular carcinoma and promotes cancer cell invasiveness and angiogenesis	10
Homozygous WASHC4 variant in two sisters causes a syndromic phenotype defined by dysmorphisms, intellectual disability, profound developmental disorder, and skeletal muscle involveme	10
Reducing the risks of nuclear war – the role of health professionals	10
Unravelling the tumour genome: The evolutionary and clinical impacts of structural variants in tumourigenesis	10
Activated immune infiltrates expand opportunities for targeted therapy in p53‐abnormal endometrial carcinoma	10
P2X4 purinergic receptors offer a therapeutic target for aggressive prostate cancer	10
TP53 disruptive mutation predicts platinum‐based chemotherapy and PD‐1/PD‐L1 blockade response in urothelial carcinoma	10
Elevated NPM1 and FBL expression correlates with prostate cancer aggressiveness and progression	10
Spatial transcriptomics exploration of the primary neuroblastoma microenvironment in archived FFPE samples unveils novel paracrine interactions	9
Chemokine profiling of melanoma–macrophage crosstalk identifies CCL8 and CCL15 as prognostic factors in cutaneous melanoma	9
Afadin loss induces breast cancer metastasis through destabilisation of E‐cadherin to F‐actin linkage	9
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Issue Information	9
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Peak density of immature nerve cells occurs with high‐grade dysplasia in intraductal papillary mucinous neoplasms of the pancreas	9
Distinct genomic landscapes in radiation‐associated angiosarcoma compared with other radiation‐associated sarcoma histologies	9
Issue Information	9
Mucinous cystic neoplasms of the pancreas and liver share a similar DNA methylation profile with mucinous ovarian tumors	9
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Cancer‐associated fibroblasts potentiate colorectal cancer progression by crosstalk of the IGF2–IGF1R and Hippo–YAP1 signaling pathways	9
Discoidin domain receptor 2 signaling through PIK3C2α in fibroblasts promotes lung fibrosis	9
List of Reviewers	9
Advancing gastric cancer precision medicine with novel genomic screens†	8
Reconstructing the epidermal proteolytic cascades in health and disease	8
BCG invokes superior STING‐mediated innate immune response over radiotherapy in a carcinogen murine model of urothelial cancer	8
Expression patterns and prognostic relevance of subtype‐specific transcription factors in surgically resected small‐cell lung cancer: an international multicenter study	8
Issue Information	8
Monoallelic deleterious MUTYH germline variants as a driver for tumorigenesis	8
Intestinal overgrowth of Candida albicans exacerbates bleomycin‐induced pulmonary fibrosis in mice with dysbiosis	8
Functional genomics screening identifies aspartyl‐tRNA synthetase as a novel prognostic marker and a therapeutic target for gastric cancers	8
Correction to ‘Hourglass, a compass navigating global and regional heterogeneity of pancreatic cancer’	8
Utilizing aptamers in targeted protein degradation strategies for disease therapy	8
Multisystem screening reveals SARS‐CoV‐2 in neurons of the myenteric plexus and in megakaryocytes	8
A breast cancer PDX collection enriched in luminal (ER+) tumors and young premenopausal patients to identify new therapeutic strategies for high‐risk patients†	8
Discordant prognosis of mismatch repair deficiency in colorectal and endometrial cancer reflects variation in antitumour immune response and immune escape	8
A dominant negative Kcnd3 F227del mutation in mice causes spinocerebellar ataxia type 22 (SCA22) by impairing ER and Golgi functioning	8
Comprehensive molecular characterization of adenoid cystic carcinoma reveals tumor suppressors as novel drivers and prognostic biomarkers	8
TGF‐β3 from fibroblasts promotes necrotising sialometaplasia by suppressing salivary gland cell proliferation and inducing squamous metaplasia	8
Multiomics sequencing and immune microenvironment characteristics define three subtypes of small cell neuroendocrine carcinoma of the cervix	8
Mechanisms regulating vascular and lymphatic regeneration in the heart after myocardial infarction	8
Issue Information	8
Ductal carcinoma in situ develops within clonal fields of mutant cells in morphologically normal ducts	8
Definitive study shows no association between ARID1A mutation status and clinical outcome in endometriosis‐related ovarian cancers‡	8
STING1 deficiency ameliorates immune‐mediated crescentic glomerulonephritis in mice	8
Thrombospondin‐1 binds to integrin β3 to inhibit vascular calcification through suppression of NF‐κB pathway	7
NTRK oncogenic fusions are exclusively associated with the serrated neoplasia pathway in the colorectum and begin to occur in sessile serrated lesions	7
AI‐guided histopathology predicts brain metastasis in lung cancer patients	7
Single‐cell transcriptomic analysis reveals that the APP–CD74 axis promotes immunosuppression and progression of testicular tumors	7
‘Splicing predictions, minigene analyses, and ACMG‐AMP clinical classification of 42 germline PALB2 splice‐site variants’	7
Alternative driver pathways in peripheral nerve sheath tumors – including DICER1 and/or KRAS alterations	7
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Genetic and immune landscape evolution in MMR‐deficient colorectal cancer	7
Glomerular basement membrane deposition of collagen α1(III) in Alport glomeruli by mesangial filopodia injures podocytes via aberrant signaling through DDR1 and integr	7
Cardiac decompensation and promiscuous prenylation of small GTPases in cardiomyocytes in response to local mevalonate pathway disruption†	7
Initial interactions with the FDA on developing a validation dataset as a medical device development tool	7
Correction to ‘Quantitative proteomics identifies altered O‐GlcNAcylation of structural, synaptic and memory‐associated proteins in Alzheimer's disease’	7
Redefining phenotypic intratumor heterogeneity of pancreatic ductal adenocarcinoma: a bottom‐up approach	7
Cytoplasmic SIRT1 promotes paclitaxel resistance in ovarian carcinoma through increased formation and survival of polyploid giant cancer cells	7
Mitochondria govern histone acetylation in colorectal cancer	7
Abstracts	7
Concerns about pathology expertise and data quality	7
Tumor‐immune landscape patterns before and after chemoradiation in resectable esophageal adenocarcinomas	7
DNA methylation as a new tool for the differential diagnosis between T‐LBL and lymphocyte‐rich thymoma	7
Issue Information	6
Nondestructive3Dpathology with analysis of nuclear features for prostate cancer risk assessment	6
The significance of PAX5 in Merkel cell carcinoma	6
Biological and clinical significance of the YKL‐40/osteopontin–integrin β4–p70S6K axis induced by macrophages in early oesophageal squamous cell carcinoma	6
Aberrant TERT expression: linking chronic inflammation to hepatocellular carcinoma†	6
The utility of color normalization for AI‐based diagnosis of hematoxylin and eosin‐stained pathology images	6
Manchester Pathology 2021. 13th Joint Meeting of the British Division of the International Academy of Pathology and the Pathological Society of Great Britain & Ireland, 6–8 July 2021	6
Mucosal melanomas of different anatomic sites share a common global DNA methylation profile with cutaneous melanoma but show location‐dependent patterns of genetic and epigenetic alteration	6
Automated tumor immunophenotyping predicts clinical benefit from anti‐PD‐L1 immunotherapy	6
Partial‐EMT cell state correlates with single cell pattern of invasion in head and neck SCC keratinocytes	6
Single‐cell profiling identifies distinct hormonal, immunologic, and inflammatory signatures of endometriosis‐constituting cells	6
Unveiling the intriguing relationship: oncogenic KRAS, morphological shifts, and mutational complexity in pancreatic mucinous cystic neoplasms	6
The Lund taxonomy for bladder cancer classification – from gene expression clustering to cancer cell molecular phenotypes, and back again	6
Jeremy Jass Prize for Research Excellence in Pathology 2022	6
Integrative multi‐omic analysis reveals neurodevelopmental gene dysregulation in CIC‐knockout and IDH1‐mutant cells	6
GPNMB expression identifies TSC1/2/mTOR‐associated and MiT family translocation‐driven renal neoplasms	6
Comprehensive clinicopathological, molecular, and methylation analysis of mesenchymal tumors with NTRK and other kinase gene aberrations	6
A digital score of peri‐epithelial lymphocytic activity predicts malignant transformation in oral epithelial dysplasia	6
Insulin‐degrading enzyme: an ally against metabolic and neurodegenerative diseases	6
Persistent SARS‐CoV‐2 infection in patients seemingly recovered from COVID‐19	6
Extracellular matrix cancer‐associated fibroblasts promote stromal fibrosis and immune exclusion in triple‐negative breast cancer	5
Genomic analysis of spermatocytic tumors demonstrates recurrent molecular alterations in cases with malignant clinical behavior	5
Inhibition of EZH2 suppresses peritoneal angiogenesis by targeting a VEGFR2/ERK1/2/HIF‐1α‐dependent signaling pathway	5
EBV infection mediated BDNF expression is associated with bladder inflammation in interstitial cystitis/bladder pain syndrome with Hunner's lesion	5
Cancer‐associated fibroblasts in pancreatic cancer: new subtypes, new markers, new targets	5
The case for homebrew AI in diagnostic pathology	5
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Inflammatory capacity of exosomes released in the early stages of acute pancreatitis predicts the severity of the disease	5
Absence of NOTCH1 mutation and presence of CDKN2A deletion predict progression of esophageal lesions	5