Journal of Pathology

Article	Citations
‘Know thyself’ – host factors influencing cancer response to immune checkpoint inhibitors	159
CXCR4 mediates leukemic cell migration and survival in the testicular microenvironment	86
SMARCA4‐deficient rhabdoid tumours show intermediate molecular features between SMARCB1‐deficient rhabdoid tumours and small cell carcinomas of the ovary, hypercalcaemic type	80
Ovarian high‐grade serous carcinoma cells with low SMARCA4 expression and high SMARCA2 expression contribute to platinum resistance	77
Intravenous iron treatment fuels chronic kidney disease‐induced arterial media calcification in rats	76
Modelling hereditary diffuse gastric cancer initiation using transgenic mouse‐derived gastric organoids and single‐cell sequencing	73
Probing the tumorigenic potential of genetic interactions reconstituted in murine fallopian tube organoids	67
Novel prognostication biomarker adipophilin reveals a metabolic shift in uveal melanoma and new therapeutic opportunities	63
Spatial profiling of ANO7 in prostate tissue: links to AR‐signalling‐associated lipid metabolism and inflammation	59
A new FGF15/19‐mediated gut‐to‐heart axis controls cardiac hypertrophy	54
Breathing in danger: how particulate matter pollution is putting the public at risk of lung cancer†	52
Collagen VI promotes recovery from colitis by inducing lymphangiogenesis and drainage of inflammatory cells	51
The association between the tumor immune microenvironments and clinical outcome in low‐grade, early‐stage endometrial cancer patients	50
Presence of Tim3+ and PD‐1+CD8+T cells identifies microsatellite stable colorectal carcinomas with immune exhaustion and di	48
Integration of peripheral blood‐ and tissue‐based biomarkers of response to immune checkpoint blockade in urothelial carcinoma	47
Issue Information	46
High‐resolution and quantitative spatial analysis reveal intra‐ductal phenotypic and functional diversification in pancreatic cancer	46
Artificial intelligence to identify genetic alterations in conventional histopathology	43
Escape from senescence: molecular basis and therapeutic ramifications	41
Identification of tumour‐infiltrating myeloid subsets associated with overall survival in lung squamous cell carcinoma	40
Pseudobudding: ruptured glands do not represent true tumor buds	39
Genomic features of Helicobacter pylori‐naïve diffuse‐type gastric cancer	39
CRISPR–Cas9 screening identifies the role of FER as a tumor suppressor	38
In high‐grade ovarian carcinoma, platinum‐sensitive tumor recurrence and acquired‐resistance derive from quiescent residual cancer cells that overexpress CRYAB, CEACAM6, and	38
The E2F1–HOXB9/PBX2–CDK6 axis drives gastric tumorigenesis and serves as a therapeutic target in gastric cancer	37

Field cancerization in breast cancer	37
Human scattered tubular cells represent a heterogeneous population of glycolytic dedifferentiated proximal tubule cells	37
Integrating computational pathology and proteomics to address tumor heterogeneity	33
Platelet C3G protects from liver fibrosis, while enhancing tumor growth through regulation of the immune response	33
Silencing GRHL3 promotes multiple organ distant metastasis of lung squamous cell carcinoma cells by enhancing SOX2 stability via SIRT1	31
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Downregulated BMP–Smad1/5/8 signaling causes emphysema via dysfunction of alveolar type II epithelial cells	29
Primary thyroid B‐cell lymphoma: molecular insights into its clonal evolution and relapse	29
Development of a multi‐scanner facility for data acquisition for digital pathology artificial intelligence	29
On the origin of gastric tumours: analysis of a case with intramucosal gastric carcinoma and oxyntic gland adenoma	29
Characterisation of an enhanced preclinical model of experimental MPO‐ANCA autoimmune vasculitis	28
Integrative analysis of genomic and transcriptomic data of normal, tumour, and co‐occurring leukoplakia tissue triads drawn from patients with gingivobuccal oral cancer identifies signatures of tumour	27
The early evolutionary landscape of osteosarcoma provides clues for targeted treatment strategies	27
Genetic and epigenetic alterations in precursor lesions of endometrial endometrioid carcinoma	27
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Minigene‐based splicing analysis and ACMG/AMP‐based tentative classification of 56 ATM variants	27
Prediction of coexisting invasive carcinoma on ductal carcinoma in situ (DCIS) lesions by mass spectrometry imaging	27
Issue Information	27
Increased expression of phosphodiesterase 4 in activated hepatic stellate cells promotes cytoskeleton remodeling and cell migration	26
Adrenomedullin2 stimulates progression of thyroid cancer in mice and humans under nutrient excess conditions	26
Canonical Kaiso target genes define a functional signature that associates with breast cancer survival and the invasive lobular carcinoma histological type	25
Issue Information	25
Copy‐number intratumor heterogeneity increases the risk of relapse in chemotherapy‐naive stage II colon cancer	25
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Somatic loss ofATMis a late event in pancreatic tumorigenesis	24
Random forest modelling demonstrates microglial and protein misfolding features to be key phenotypic markers in C9orf72‐ALS	24
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Lineage tracing in human tissues	23
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PIK3CA mutation subtype delineates distinct immune profiles in gastric carcinoma	23
BMP signalling in colorectal cancer: losing the yin to WNTs yang	23
Tumor immune microenvironment alterations associated with progression in human intraductal papillary mucinous neoplasms	23
Deep learning based on hematoxylin–eosin staining outperforms immunohistochemistry in predicting molecular subtypes of gastric adenocarcinoma	22
PCDHGC3 hypermethylation as a potential biomarker of intestinal neuroendocrine carcinomas	22
Integrated molecular characterization of esophageal basaloid squamous cell carcinoma: a subtype with distinct RNA expression pattern and immune characteristics, but no specific genetic muta	22
The earliest events in BRAF‐mutant colorectal cancer: exome sequencing of sessile serrated lesions with a tiny focus dysplasia or cancer reveals recurring mutations in two distinct p	21
Issue Information	21
Long‐term treatment of cancer‐prone germline PTEN mutant mice with low‐dose rapamycin extends lifespan and delays tumour development	21
Transcriptomics and proteomics reveal distinct biology for lymph node metastases and tumour deposits in colorectal cancer	21
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Pitfalls in machine learning‐based assessment of tumor‐infiltrating lymphocytes in breast cancer: A report of the International Immuno‐Oncology Biomarker Working Group on Breast Cancer	21
Issue Information	21
Organoids in cancer research: a review for pathologist‐scientists	21
Liver insulin‐like growth factor‐1 mediates effects of low‐intensity vibration on wound healing in diabetic mice	20
C1GALT1 expression predicts poor survival in osteosarcoma and is crucial for ABCC1 transporter‐mediated doxorubicin resistance	20
Genomic analysis and preclinical xenograft model development identify potential therapeutic targets for MYOD1‐mutant soft‐tissue sarcoma of childhood	20
DNA methylation patterns are influenced by Pax3::Foxo1 expression and developmental lineage in rhabdomyosarcoma tumours forming in genetically engineered	20
Cell division‐dependent dissemination following E‐cadherin loss underlies initiation of diffuse‐type gastric cancer	20

Assessing spatial sequencing and imaging approaches to capture the molecular and pathological heterogeneity of archived cancer tissues	20
Multiregion exome sequencing indicates a monoclonal origin of esophageal spindle‐cell squamous cell carcinoma	19
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Macrophages producing chondroitin sulfate proteoglycan‐4 induce neuro‐cardiac junction impairment in Duchenne muscular dystrophy	19
Caspase activation in tumour‐infiltrating lymphocytes is associated with lymph node metastasis in oral squamous cell carcinoma	19
Proteomic profiling identifies novel diagnostic biomarkers and molecular subtypes for mucinous tubular and spindle cell carcinoma of the kidney	18
Re‐interpreting tumour behaviour and the tumour microenvironment as normal responses to tissue disorganisation	18
SOX9 has distinct roles in the formation and progression of different non‐small cell lung cancer histotypes	18
Fusion with type 2 macrophages induces melanoma cell heterogeneity that potentiates immunological escape from cytotoxic T lymphocytes	18
Differential involvement of LUBAC‐mediated linear ubiquitination in intestinal epithelial cells and macrophages during intestinal inflammation	17
Pancancer cytotoxic T‐cell trapping: are neutrophil extracellular traps a viable biomarker for immunotherapy response?†	17
Defining the first bona fide cell model for SMARCA4‐deficient, undifferentiated tumor	17
Divergent evolution of metachronous follicular lymphoma and extranodal marginal zone lymphoma of mucosa‐associated lymphoid tissue from a common precursor	17
Dystrophin deficiency impairs vascular structure and function in the canine model of Duchenne muscular dystrophy	17
Human colonic organoids for understanding early events of familial adenomatous polyposis pathogenesis	17
Expanding the clinicopathologic spectrum and genomic landscape of tumors with SMARCA2/4::CREM fusions	16
Spasmolytic polypeptide‐expressing metaplasia (SPEM) cell lineages can be an origin of gastric cancer	16
Transcriptomic profiles of myxofibrosarcoma and undifferentiated pleomorphic sarcoma correlate with clinical and genomic features	16
Histone deacetylase 6 inhibition attenuates pathological cardiac hypertrophy by promoting autophagy through MAP1LC3B ubiquitination	16
Genetic alterations during the neoplastic cascade towards cholangiocarcinoma in primary sclerosing cholangitis	16
Anti‐CD40L therapy prevents the formation of precursor lesions to gastric B‐cell MALT lymphoma in a mouse model	16
The state of the art for artificial intelligence in lung digital pathology	15
Consensus molecular subtype transition during progression of colorectal cancer	15
Stress testing deep learning models for prostate cancer detection on biopsies and surgical specimens	15
Unleashing the potential of AI for pathology: challenges and recommendations	15
Jeremy Jass Prize for Research Excellence in Pathology 2021	15
Issue Information	15
The spectrum and significance of secondary (co‐occurring) genetic alterations in sarcomas: the hallmarks of sarcomagenesis	15
Cdt1 overexpression drives colorectal carcinogenesis through origin overlicensing and DNA damage	15
Evidence for etiologic field changes in tongue distant from tumor in patients with squamous cell carcinoma of the oral tongue	15
UPK3A+ umbrella cell damage mediated by TLR3–NR2F6 triggers programmed destruction of urothelium in Hunner‐type interstitial cystitis/painful bladder syndrome	15
Issue Information	14
Immune‐related gene expression signatures: a step forward in the stratification of patients with ovarian clear cell carcinoma†	14
PI3 expression predicts recurrence after chemotherapy with DNA‐damaging drugs in gastric cancer	14
Optical genome mapping identifies a germline retrotransposon insertion in SMARCB1 in two siblings with atypical teratoid rhabdoid tumors	14
RAF1–MEK/ERK pathway‐dependent ARL4C expression promotes ameloblastoma cell proliferation and osteoclast formation	14
‘Experimentally‐induced anti‐myeloperoxidase vasculitis does not require properdin, MASP‐2 or bone marrow‐derived C5’	14
Genomic analysis defines distinct pancreatic and neuronal subtypes of lung carcinoid	14
Integrative analysis of transcriptomic and metabolomic profiles reveals abnormal phosphatidylinositol metabolism in follicles from endometriosis‐associated infertility patients	14
Metformin confers sensitisation to syrosingopine in multiple myeloma cells by metabolic blockage and inhibition of protein synthesis	14
Local factor H production by human choroidal endothelial cells mitigates complement deposition: implications for macular degeneration	14
Indoleamine 2,3‐dioxygenase (IDO)‐1 and IDO‐2 activity and severe course of COVID‐19	14
Clinical significance of pancreatic ductal metaplasia	14
Application of digital pathology‐based advanced analytics of tumour microenvironment organisation to predict prognosis and therapeutic response	14
Issue Information	14
Fibrinogen Aα‐chain amyloidosis outbreaks in Japanese squirrels (Sciurus lis): a potential disease model	13
Computer‐extracted features of nuclear morphology in hematoxylin and eosin images distinguish stage II and IV colon tumors	13
Nuclear pCHK1 as a potential biomarker of increased sensitivity to ATR inhibition	13
Brg1 is required to maintain colorectal cancer stem cells	13
Clonal dynamics of chronic myelomonocytic leukemia progression: paired‐sample comparison	13
Extracellular vesicles arising from apoptosis: forms, functions, and applications	13
Interaction of the tumor suppressor SMAD4 and WNT signaling in progression to oral squamous cell carcinoma	13
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CD27/CD70 pathway activation in primary cutaneous CD4+ small/medium T‐cell lymphoproliferative disorder	13
Abstracts	13
Disordered farnesoid X receptor signaling is associated with liver carcinogenesis in Abcb11‐deficient mice	13
Computational pathology in cancer diagnosis, prognosis, and prediction – present day and prospects	13
Lack of EGFR catalytic activity in hepatocytes improves liver regeneration following DDC‐induced cholestatic injury by promoting a pro‐restorative inflammatory response	13
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Issue Information	13
Tumor‐infiltrating lymphocytes‐based subtypes and genomic characteristics of EBV‐associated lymphoepithelioma‐like carcinoma	13
Contribution of alterations in peritubular capillary density and microcirculation to the progression of tubular injury and kidney fibrosis	13
Comprehensive splicing analysis of the alternatively spliced CHEK2 exons 8 and 10 reveals three enhancer/silencer‐rich regions and 38 spliceogenic variants	12
Issue Information	12
Role of Toll‐like receptor 4 in intravascular hemolysis‐mediated injury	12
Dual inhibition of the endothelin and angiotensin receptor ameliorates renal and inner ear pathologies in Alport mice	12
Oronasal mucosal melanoma is defined by two transcriptional subtypes in humans and dogs with implications for diagnosis and therapy	12
Molecular genetic evidence supporting diverse histogenic origins of germ cell tumors	12
FOXL2C134W: much ado about something!†	12
FOXL2 in adult‐type granulosa cell tumour of the ovary: oncogene or tumour suppressor gene?	12
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Disseminated cancer cells detected by immunocytology in lymph nodes of NSCLC patients are highly prognostic and undergo parallel molecular evolution	12
NEIL3 promotes hepatoma epithelial–mesenchymal transition by activating the BRAF/MEK/ERK/TWIST signaling pathway	12
Ferrostatin‐1 modulates dysregulated kidney lipids in acute kidney injury	11
The phospholipid flippase ATP9A enhances macropinocytosis to promote nutrient starvation tolerance in hepatocellular carcinoma	11
Downregulation of HDAC9 by the ketone metabolite β‐hydroxybutyrate suppresses vascular calcification	11
Disorganisation of basement membrane zone architecture impairs melanocyte residence in vitiligo	11

Validated biomarker assays confirm that ARID1A loss is confounded with MMR deficiency, CD8+ TIL infiltration, and provides no independent prognostic value i	11
A Tc1‐ and Th1‐T‐lymphocyte‐rich tumor microenvironment is a hallmark of MSI colorectal cancer	11
P2X4 purinergic receptors offer a therapeutic target for aggressive prostate cancer	10
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Homozygous WASHC4 variant in two sisters causes a syndromic phenotype defined by dysmorphisms, intellectual disability, profound developmental disorder, and skeletal muscle involveme	10
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Reducing the risks of nuclear war – the role of health professionals	10
Cancer‐associated fibroblasts potentiate colorectal cancer progression by crosstalk of the IGF2–IGF1R and Hippo–YAP1 signaling pathways	10
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Peak density of immature nerve cells occurs with high‐grade dysplasia in intraductal papillary mucinous neoplasms of the pancreas	10
Muramyl dipeptide alleviates estrogen deficiency‐induced osteoporosis through canonical Wnt signaling	9
Activated immune infiltrates expand opportunities for targeted therapy in p53‐abnormal endometrial carcinoma	9
Distinct genomic landscapes in radiation‐associated angiosarcoma compared with other radiation‐associated sarcoma histologies	9
Oncostatin M is overexpressed in NASH‐related hepatocellular carcinoma and promotes cancer cell invasiveness and angiogenesis	9
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TP53 disruptive mutation predicts platinum‐based chemotherapy and PD‐1/PD‐L1 blockade response in urothelial carcinoma	9
Discoidin domain receptor 2 signaling through PIK3C2α in fibroblasts promotes lung fibrosis	9
Afadin loss induces breast cancer metastasis through destabilisation of E‐cadherin to F‐actin linkage	9
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Advancing gastric cancer precision medicine with novel genomic screens†	9
Unravelling the tumour genome: The evolutionary and clinical impacts of structural variants in tumourigenesis	9
Chemokine profiling of melanoma–macrophage crosstalk identifies CCL8 and CCL15 as prognostic factors in cutaneous melanoma	9
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Utilizing aptamers in targeted protein degradation strategies for disease therapy	8
List of Reviewers	8
Mechanisms regulating vascular and lymphatic regeneration in the heart after myocardial infarction	8
Expression patterns and prognostic relevance of subtype‐specific transcription factors in surgically resected small‐cell lung cancer: an international multicenter study	8
Cytoplasmic SIRT1 promotes paclitaxel resistance in ovarian carcinoma through increased formation and survival of polyploid giant cancer cells	8
Issue Information	8
Comprehensive molecular characterization of adenoid cystic carcinoma reveals tumor suppressors as novel drivers and prognostic biomarkers	8
Multiomics sequencing and immune microenvironment characteristics define three subtypes of small cell neuroendocrine carcinoma of the cervix	8
Multisystem screening reveals SARS‐CoV‐2 in neurons of the myenteric plexus and in megakaryocytes	8
Reconstructing the epidermal proteolytic cascades in health and disease	8
A breast cancer PDX collection enriched in luminal (ER+) tumors and young premenopausal patients to identify new therapeutic strategies for high‐risk patients†	8
Correction to ‘Hourglass, a compass navigating global and regional heterogeneity of pancreatic cancer’	8
Non‐syndromic thoracic aortic aneurysm: cellular and molecular insights	8
Functional genomics screening identifies aspartyl‐tRNA synthetase as a novel prognostic marker and a therapeutic target for gastric cancers	8
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TGF‐β3 from fibroblasts promotes necrotising sialometaplasia by suppressing salivary gland cell proliferation and inducing squamous metaplasia	8
BCG invokes superior STING‐mediated innate immune response over radiotherapy in a carcinogen murine model of urothelial cancer	8
Issue Information	8
Glomerular basement membrane deposition of collagen α1(III) in Alport glomeruli by mesangial filopodia injures podocytes via aberrant signaling through DDR1 and integr	7
Single‐cell transcriptomic analysis reveals that the APP–CD74 axis promotes immunosuppression and progression of testicular tumors	7
Concerns about pathology expertise and data quality	7
Cardiac decompensation and promiscuous prenylation of small GTPases in cardiomyocytes in response to local mevalonate pathway disruption†	7
Redefining phenotypic intratumor heterogeneity of pancreatic ductal adenocarcinoma: a bottom‐up approach	7
STING1 deficiency ameliorates immune‐mediated crescentic glomerulonephritis in mice	7
Definitive study shows no association between ARID1A mutation status and clinical outcome in endometriosis‐related ovarian cancers‡	7
Ductal carcinoma in situ develops within clonal fields of mutant cells in morphologically normal ducts	7
AI‐guided histopathology predicts brain metastasis in lung cancer patients	7
Tumor‐immune landscape patterns before and after chemoradiation in resectable esophageal adenocarcinomas	7
The Lund taxonomy for bladder cancer classification – from gene expression clustering to cancer cell molecular phenotypes, and back again	7
Discordant prognosis of mismatch repair deficiency in colorectal and endometrial cancer reflects variation in antitumour immune response and immune escape	7
NTRK oncogenic fusions are exclusively associated with the serrated neoplasia pathway in the colorectum and begin to occur in sessile serrated lesions	7
A dominant negative Kcnd3 F227del mutation in mice causes spinocerebellar ataxia type 22 (SCA22) by impairing ER and Golgi functioning	7
Mitochondria govern histone acetylation in colorectal cancer	7
Intestinal overgrowth of Candida albicans exacerbates bleomycin‐induced pulmonary fibrosis in mice with dysbiosis	7
Heterogenous presence of neutrophil extracellular traps in human solid tumours is partially dependent on IL‐8	7
Issue Information	7
Abstracts	7
Monoallelic deleterious MUTYH germline variants as a driver for tumorigenesis	7
Genetic and immune landscape evolution in MMR‐deficient colorectal cancer	7
Alternative driver pathways in peripheral nerve sheath tumors – including DICER1 and/or KRAS alterations	6
Identification and characterization of primary cilia‐positive salivary gland tumours exhibiting basaloid/myoepithelial differentiation	6
DNA methylation as a new tool for the differential diagnosis between T‐LBL and lymphocyte‐rich thymoma	6
Unveiling the intriguing relationship: oncogenic KRAS, morphological shifts, and mutational complexity in pancreatic mucinous cystic neoplasms	6
‘NR4A3 fusion proteins trigger an axon guidance switch that marks the difference between EWSR1 and TAF15 translocated extraskeletal myxoid chondrosarcomas’	6
Insulin‐degrading enzyme: an ally against metabolic and neurodegenerative diseases	6
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The utility of color normalization for AI‐based diagnosis of hematoxylin and eosin‐stained pathology images	6
Correction to ‘Quantitative proteomics identifies altered O‐GlcNAcylation of structural, synaptic and memory‐associated proteins in Alzheimer's disease’	6
Manchester Pathology 2021. 13th Joint Meeting of the British Division of the International Academy of Pathology and the Pathological Society of Great Britain & Ireland, 6–8 July 2021	6
A digital score of peri‐epithelial lymphocytic activity predicts malignant transformation in oral epithelial dysplasia	6
Thrombospondin‐1 binds to integrin β3 to inhibit vascular calcification through suppression of NF‐κB pathway	6
Initial interactions with the FDA on developing a validation dataset as a medical device development tool	6
‘Splicing predictions, minigene analyses, and ACMG‐AMP clinical classification of 42 germline PALB2 splice‐site variants’	6
Persistent SARS‐CoV‐2 infection in patients seemingly recovered from COVID‐19	6
Jeremy Jass Prize for Research Excellence in Pathology 2022	6
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Absence of NOTCH1 mutation and presence of CDKN2A deletion predict progression of esophageal lesions	5
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BOP1 confers chemoresistance of triple‐negative breast cancer by promoting CBP‐mediated β‐catenin acetylation	5
Exploring the molecular landscape of cutaneous mixed tumors characterized by TRPS1::PLAG1 gene fusion	5
Multiomic spatial atlas shows deleted in malignant brain tumors 1 (DMBT1) glycoprotein is lost in colonic dysplasia	5
Extracellular matrix cancer‐associated fibroblasts promote stromal fibrosis and immune exclusion in triple‐negative breast cancer	5
Genetic context of oncogenic drivers dictates vascular sarcoma development in aP2‐Cre mice	5
Cancer‐associated fibroblast heterogeneity in chordoma†	5
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Dynamic change of polarity in spread through air spaces of pulmonary malignancies	5
Inhibition of EZH2 suppresses peritoneal angiogenesis by targeting a VEGFR2/ERK1/2/HIF‐1α‐dependent signaling pathway	5