Journal of Molecular Biology

Article	Citations
AlphaFold and Implications for Intrinsically Disordered Proteins	356
Structural insights into SARS-CoV-2 proteins	260
Moltemplate: A Tool for Coarse-Grained Modeling of Complex Biological Matter and Soft Condensed Matter Physics	246
Experimental Evidence for Enhanced Receptor Binding by Rapidly Spreading SARS-CoV-2 Variants	182
Apoptosis, Pyroptosis, and Necroptosis—Oh My! The Many Ways a Cell Can Die	177
FunRich enables enrichment analysis of OMICs datasets	176
The AlphaFold Database of Protein Structures: A Biologist’s Guide	161
RCSB Protein Data Bank: Architectural Advances Towards Integrated Searching and Efficient Access to Macromolecular Structure Data from the PDB Archive	132
The Mechanism and Consequences of SARS-CoV-2 Spike-Mediated Fusion and Syncytia Formation	115
EFI-EST, EFI-GNT, and EFI-CGFP: Enzyme Function Initiative (EFI) Web Resource for Genomic Enzymology Tools	112
A Brief History of De Novo Protein Design: Minimal, Rational, and Computational	101
Crystal Structure of NLRP3 NACHT Domain With an Inhibitor Defines Mechanism of Inflammasome Inhibition	89
Structure and Function of Chromatin Remodelers	87
Liquid-Liquid Phase Separation of Tau Driven by Hydrophobic Interaction Facilitates Fibrillization of Tau	85
Molecular Mechanisms for Bacterial Potassium Homeostasis	82
Cation-π Interactions and their Functional Roles in Membrane Proteins	81
Sequence Determinants of the Aggregation of Proteins Within Condensates Generated by Liquid-liquid Phase Separation	79
The Paf1 Complex: A Keystone of Nuclear Regulation Operating at the Interface of Transcription and Chromatin	78
Synapsin Condensates Recruit alpha-Synuclein	75
Structural Modeling of the SARS-CoV-2 Spike/Human ACE2 Complex Interface can Identify High-Affinity Variants Associated with Increased Transmissibility	74
Mechanisms of Antiviral Immune Evasion of SARS-CoV-2	72
The Groovy TMEM16 Family: Molecular Mechanisms of Lipid Scrambling and Ion Conduction	68
Molecular Strategies Underlying Porphyromonas gingivalis Virulence	68
The Mechanism of SARS-CoV-2 Nucleocapsid Protein Recognition by the Human 14-3-3 Proteins	67
GeneCaRNA: A Comprehensive Gene-centric Database of Human Non-coding RNAs in the GeneCards Suite	67

Energy Landscapes of Protein Aggregation and Conformation Switching in Intrinsically Disordered Proteins	66
Subtle Influence of ACE2 Glycan Processing on SARS-CoV-2 Recognition	65
The Diverse Functions of Small Heat Shock Proteins in the Proteostasis Network	64
SARS-CoV-2 Fusion Peptide has a Greater Membrane Perturbating Effect than SARS-CoV with Highly Specific Dependence on Ca2+	61
The Protein Folding Problem: The Role of Theory	61
Contributions of Histone Variants in Nucleosome Structure and Function	61
On the Potential of Machine Learning to Examine the Relationship Between Sequence, Structure, Dynamics and Function of Intrinsically Disordered Proteins	60
The Persistent Question of Potassium Channel Permeation Mechanisms	60
Liquid-liquid Phase Separation of α-Synuclein: A New Mechanistic Insight for α-Synuclein Aggregation Associated with Parkinson's Disease Pathogenesis	59
Structural Basis of Drug Recognition by the Multidrug Transporter ABCG2	58
Uncovering Non-random Binary Patterns Within Sequences of Intrinsically Disordered Proteins	58
On the molecular nature of large-pore channels	57
Molecular Mechanism of Nramp-Family Transition Metal Transport	57
The BioImage Archive – Building a Home for Life-Sciences Microscopy Data	57
Enzymatic Reactions inside Biological Condensates	56
Regulatory B cells and T cell Regulation in Cancer	56
Pyroptosis-Induced Inflammation and Tissue Damage	56
iDRBP_MMC: Identifying DNA-Binding Proteins and RNA-Binding Proteins Based on Multi-Label Learning Model and Motif-Based Convolutional Neural Network	54
Merging Established Mechanisms with New Insights: Condensates, Hubs, and the Regulation of RNA Polymerase II Transcription	54
Towards Visual Proteomics at High Resolution	53
PANoptosis in Viral Infection: The Missing Puzzle Piece in the Cell Death Field	52
Mechanisms of Transcription Elongation Factor DSIF (Spt4–Spt5)	50
AlphaFold and the amyloid landscape	50
MLCPP 2.0: An Updated Cell-penetrating Peptides and Their Uptake Efficiency Predictor	48
Single-Molecule Force Spectroscopy of Protein Folding	47
Structural Insights into the Mechanisms and Pharmacology of K2P Potassium Channels	47
A Crystallographic Snapshot of SARS-CoV-2 Main Protease Maturation Process	47
PDBx/mmCIF Ecosystem: Foundational Semantic Tools for Structural Biology	47
Community-Wide Experimental Evaluation of the PROSS Stability-Design Method	46
Disulfide Bonds Play a Critical Role in the Structure and Function of the Receptor-binding Domain of the SARS-CoV-2 Spike Antigen	46
Cppsite 2.0: An Available Database of Experimentally Validated Cell-Penetrating Peptides Predicting their Secondary and Tertiary Structures	46
PPD: A Manually Curated Database for Experimentally Verified Prokaryotic Promoters	45
Prion-like C-Terminal Domain of TDP-43 and α-Synuclein Interact Synergistically to Generate Neurotoxic Hybrid Fibrils	45
3dRNA: 3D Structure Prediction from Linear to Circular RNAs	45
Pyroptosis, and its Role in Central Nervous System Disease	45
Regulation of Lytic and Non-Lytic Functions of Gasdermin Pores	43
Regulation of Promoter Proximal Pausing of RNA Polymerase II in Metazoans	43
Structural Pharmacology of TRP Channels	43
Building Structural Models of a Whole Mycoplasma Cell	42
Structural Pharmacology of Voltage-Gated Sodium Channels	42
Emerging Bioelectronics for Brain Organoid Electrophysiology	42
CHARMM-GUI PDB Manipulator: Various PDB Structural Modifications for Biomolecular Modeling and Simulation	42
THRONE: A New Approach for Accurate Prediction of Human RNA N7-Methylguanosine Sites	41
Designer Condensates: A Toolkit for the Biomolecular Architect	41
Structural Investigations of Full-Length Insulin Receptor Dynamics and Signalling	40
A Fifth of the Protein World: Rossmann-like Proteins as an Evolutionarily Successful Structural unit	40
Revealing the Threat of Emerging SARS-CoV-2 Mutations to Antibody Therapies	39
PubChem Protein, Gene, Pathway, and Taxonomy Data Collections: Bridging Biology and Chemistry through Target-Centric Views of PubChem Data	39
DNA mechanics and its biological impact	39
Structural Basis for Activation of the Heterodimeric GABAB Receptor	39

CTP-controlled liquid–liquid phase separation of ParB	39
Integrative Structural Biology in the Era of Accurate Structure Prediction	39
N-terminal Domain of TDP43 Enhances Liquid-Liquid Phase Separation of Globular Proteins	38
MEDUSA: Prediction of Protein Flexibility from Sequence	37
What do Transcription Factors Interact With?	36
Unstructural Biology of TRP Ion Channels: The Role of Intrinsically Disordered Regions in Channel Function and Regulation	36
Co-Translational Folding of the First Transmembrane Domain of ABC-Transporter CFTR is Supported by Assembly with the First Cytosolic Domain	35
On the Structural Diversity and Individuality of Polymorphic Amyloid Protein Assemblies	35
How does RNA fold dynamically?	34
Transcription Regulation Through Nascent RNA Folding	34
Binding Dynamics of Disordered Linker Histone H1 with a Nucleosomal Particle	34
Allostery: Allosteric Cancer Drivers and Innovative Allosteric Drugs	34
A Scalable Computational Approach for Simulating Complexes of Multiple Chromosomes	33
The Inherent Dynamics and Interaction Sites of the SARS-CoV-2 Nucleocapsid N-Terminal Region	33
Structural Features that Distinguish Inactive and Active PI3K Lipid Kinases	33
Mechanistic Insights into Gasdermin Pore Formation and Regulation in Pyroptosis	32
Nucleosome Clutches are Regulated by Chromatin Internal Parameters	32
An atomic model for the human septin hexamer by cryo-EM	32
Towards Decoding the Sequence-Based Grammar Governing the Functions of Intrinsically Disordered Protein Regions	32
Variations within the Glycan Shield of SARS-CoV-2 Impact Viral Spike Dynamics	32
Identification of Iron-Sulfur (Fe-S) Cluster and Zinc (Zn) Binding Sites Within Proteomes Predicted by DeepMind’s AlphaFold2 Program Dramatically Expands the Metalloproteome	32
FunCoup 5: Functional Association Networks in All Domains of Life, Supporting Directed Links and Tissue-Specificity	31
How Glutamate Promotes Liquid-liquid Phase Separation and DNA Binding Cooperativity of E. coli SSB Protein	31
Pyroptosis in Kidney Disease	31
Elephants in the Dark: Insights and Incongruities in Pentameric Ligand-gated Ion Channel Models	31
Prediction of Disordered Regions in Proteins with Recurrent Neural Networks and Protein Dynamics	30
Archaea: The Final Frontier of Chromatin	30
Structural Basis of Substrate-Independent Phosphorylation in a P4-ATPase Lipid Flippase	30
NMMD: Efficient Cryo-EM Flexible Fitting Based on Simultaneous Normal Mode and Molecular Dynamics atomic displacements	30
SARS-CoV-2 Nucleocapsid Protein Targets a Conserved Surface Groove of the NTF2-like Domain of G3BP1	29
ELASPIC2 (EL2): Combining Contextualized Language Models and Graph Neural Networks to Predict Effects of Mutations	29
PEPPI: Whole-proteome Protein-protein Interaction Prediction through Structure and Sequence Similarity, Functional Association, and Machine Learning	29
Degradation of Alzheimer’s Amyloid-β by a Catalytically Inactive Insulin-Degrading Enzyme	29
Tetravalent SARS-CoV-2 Neutralizing Antibodies Show Enhanced Potency and Resistance to Escape Mutations	28
Building Better Barrels – β-barrel Biogenesis and Insertion in Bacteria and Mitochondria	28
Phase Separation in Biology and Disease; Current Perspectives and Open Questions	28
RCSB Protein Data Bank: Efficient Searching and Simultaneous Access to One Million Computed Structure Models Alongside the PDB Structures Enabled by Architectural Advances	28
Interleukin 35 Regulatory B Cells	28
Nucleosome Positioning and Spacing: From Mechanism to Function	28
Applications of Genetic Code Expansion in Studying Protein Post-translational Modification	27
Self-assembling Shell Proteins PduA and PduJ have Essential and Redundant Roles in Bacterial Microcompartment Assembly	27
N-Terminal Finger Stabilizes the S1 Pocket for the Reversible Feline Drug GC376 in the SARS-CoV-2 Mpro Dimer	27
The promise of cryo-EM to explore RNA structural dynamics	27
Can We AlphaFold Our Way Out of the Next Pandemic?	26
ANuPP: A Versatile Tool to Predict Aggregation Nucleating Regions in Peptides and Proteins	26
Biochemical Timekeeping Via Reentrant Phase Transitions	26
Intrinsic Disorder in Human RNA-Binding Proteins	26
CavityPlus 2022 Update: An Integrated Platform for Comprehensive Protein Cavity Detection and Property Analyses with User-friendly Tools and Cavity Databases	26
Two Classes of Myosin Inhibitors, Para-nitroblebbistatin and Mavacamten, Stabilize β-Cardiac Myosin in Different Structural and Functional States	25
The Proteome Folding Problem and Cellular Proteostasis	25
Nuclear Protein Condensates and Their Properties in Regulation of Gene Expression	25
Breaths, Twists, and Turns of Atomistic Nucleosomes	25
Applications of Brain Organoids for Infectious Diseases	25
Extending the New Generation of Structure Predictors to Account for Dynamics and Allostery	25
Mechanisms and Consequences of Noncanonical Inflammasome-Mediated Pyroptosis	25
Molecular Characterisation of Titin N2A and Its Binding of CARP Reveals a Titin/Actin Cross-linking Mechanism	24
Protein Aggregation and Disaggregation in Cells and Development	24
Protein Phosphatase-1 Complex Disassembly by p97 is Initiated through Multivalent Recognition of Catalytic and Regulatory Subunits by the p97 SEP-domain Adapters	24
Effects of Mutations and Post-Translational Modifications on α-Synuclein In Vitro Aggregation	24
Dynamic Autoinhibition of the HMGB1 Protein via Electrostatic Fuzzy Interactions of Intrinsically Disordered Regions	24
Structural Insight into Phospholipid Transport by the MlaFEBD Complex from P. aeruginosa	24
Structural Insights into Transporter-Mediated Drug Resistance in Infectious Diseases	24
Functional and Pathological Effects of α-Synuclein on Synaptic SNARE Complexes	24
AlphaFold – A Personal Perspective on the Impact of Machine Learning	24
Disordered Regions Flanking the Binding Interface Modulate Affinity between CBP and NCOA	24
Mechanistic Inferences From Analysis of Measurements of Protein Phase Transitions in Live Cells	23
Emerging Methods and Applications to Decrypt Allostery in Proteins and Nucleic Acids	23
Chemical Modulation of Gasdermin-Mediated Pyroptosis and Therapeutic Potential	23
The PCDDB (Protein Circular Dichroism Data Bank): A Bioinformatics Resource for Protein Characterisations and Methods Development	23
Structural Changes in Aptamers are Essential for Synthetic Riboswitch Engineering	23
Orientational Ambiguity in Septin Coiled Coils and its Structural Basis	23
Translocon-Associated Protein Complex (TRAP) is Crucial for Co-Translational Translocation of Pre-Proinsulin	23
Structure of the Human Cholesterol Transporter ABCG1	23
TET-TDG Active DNA Demethylation at CpG and Non-CpG Sites	23
Next Generation Protein Structure Predictions and Genetic Variant Interpretation	23
Structural Identification of Individual Helical Amyloid Filaments by Integration of Cryo-Electron Microscopy-Derived Maps in Comparative Morphometric Atomic Force Microscopy Image Analysis	23
A Light-Oxygen-Voltage Receptor Integrates Light and Temperature	23
In vivo Profiling of the Alk Proximitome in the Developing Drosophila Brain	22
Common Mechanisms Underlying α-Synuclein-Induced Mitochondrial Dysfunction in Parkinson’s Disease	22
RiPPMiner-Genome: A Web Resource for Automated Prediction of Crosslinked Chemical Structures of RiPPs by Genome Mining	22

Simplicity is the Ultimate Sophistication—Crosstalk of Post-translational Modifications on the RNA Polymerase II	22
Structural Mechanisms of Mitochondrial Quality Control Mediated by PINK1 and Parkin	22
Conformational Variation in Enzyme Catalysis: A Structural Study on Catalytic Residues	22
Clusters of a Few Bound Cofilins Sever Actin Filaments	22
Pyroptosis in Steatohepatitis and Liver Diseases	22
Deep Enzymology Studies on DNA Methyltransferases Reveal Novel Connections between Flanking Sequences and Enzyme Activity	22
Glycosylation and Serological Reactivity of an Expression-enhanced SARS-CoV-2 Viral Spike Mimetic	22
Gasdermin and Gasdermin-Like Pore-Forming Proteins in Invertebrates, Fungi and Bacteria	22
The Structure and Ubiquitin Binding Properties of TRAF RING Heterodimers	21
Negatively Charged Disordered Regions are Prevalent and Functionally Important Across Proteomes	21
Cancer-related Mutations with Local or Long-range Effects on an Allosteric Loop of p53	21
Structural Analysis of Different LINC Complexes Reveals Distinct Binding Modes	20
Multifaceted N-Degron Recognition and Ubiquitylation by GID/CTLH E3 Ligases	20
B cells from Patients with Rheumatoid Arthritis Show Conserved CD39-Mediated Regulatory Function and increased CD39 Expression After Positive Response to Therapy	20
CD-NuSS: A Web Server for the Automated Secondary Structural Characterization of the Nucleic Acids from Circular Dichroism Spectra Using Extreme Gradient Boosting Decision-Tree, Neural Network and Koh	20
The N-terminal Tails of Histones H2A and H2B Adopt Two Distinct Conformations in the Nucleosome with Contact and Reduced Contact to DNA	20
Identification of NLR-associated Amyloid Signaling Motifs in Bacterial Genomes	20
Identification and Characterization of the Interaction Between the Methyl-7-Guanosine Cap Maturation Enzyme RNMT and the Cap-Binding Protein eIF4E	20
Prion Protein Biology Through the Lens of Liquid-Liquid Phase Separation	20
Recent Advances in Fluorescence Imaging by Genetically Encoded Non-canonical Amino Acids	20
The Core Complex of the Ca2+-Triggered Presynaptic Fusion Machinery	20
Mechanistic Insights into the Long-range Allosteric Regulation of KRAS Via Neurofibromatosis Type 1 (NF1) Scaffold Upon SPRED1 Loading	20
Approaching Neutrophil Pyroptosis	19
HnRNP A1/A2 Proteins Assemble onto 7SK snRNA via Context Dependent Interactions	19
Methods for Cryo-EM Single Particle Reconstruction of Macromolecules Having Continuous Heterogeneity	19
Cell Wall Stress Stimulates the Activity of the Protein Kinase StkP of Streptococcus pneumoniae, Leading to Multiple Phosphorylation	19
Structural Basis for Silicic Acid Uptake by Higher Plants	19
RAN Translation of the Expanded CAG Repeats in the SCA3 Disease Context	19
Better Cryo-EM Specimen Preparation: How to Deal with the Air–Water Interface?	19
Spatial organization of Dps and DNA–Dps complexes	19
ADDRESS: A Database of Disease-associated Human Variants Incorporating Protein Structure and Folding Stabilities	19
The Nt17 Domain and its Helical Conformation Regulate the Aggregation, Cellular Properties and Neurotoxicity of Mutant Huntingtin Exon 1	19
The Stability Landscape of de novo TIM Barrels Explored by a Modular Design Approach	19
Modeling Developmental Brain Diseases Using Human Pluripotent Stem Cells-Derived Brain Organoids – Progress and Perspective	19
Structure and the Mode of Activity of Lon Proteases from Diverse Organisms	19
Structural Basis of Main Proteases of Coronavirus Bound to Drug Candidate PF-07304814	18
Liquid–Liquid Phase Separation at the Plasma Membrane–Cytosol Interface: Common Players in Adhesion, Motility, and Synaptic Function	18
Flanking Disorder of the Folded αα-Hub Domain from Radical Induced Cell Death1 Affects Transcription Factor Binding by Ensemble Redistribution	18
The Intrinsically Disordered Proteins MLLT3 (AF9) and MLLT1 (ENL) – Multimodal Transcriptional Switches With Roles in Normal Hematopoiesis, MLL Fusion Leukemia, and Kidney Cancer	18
Principles of Alternating Access in LeuT-fold Transporters: Commonalities and Divergences	18
Novel LRR-ROC Motif That Links the N- and C-terminal Domains in LRRK2 Undergoes an Order–Disorder Transition Upon Activation	18
Gasdermin D and Beyond – Gasdermin-mediated Pyroptosis in Bacterial Infections	18
Dynamical Systems Model of RNA Velocity Improves Inference of Single-cell Trajectory, Pseudo-time and Gene Regulation	18
High-Resolution Views and Transport Mechanisms of the NKCC1 and KCC Transporters	18
Accurate Prediction of Protein Thermodynamic Stability Changes upon Residue Mutation using Free Energy Perturbation	18
MDSPACE: Extracting Continuous Conformational Landscapes from Cryo-EM Single Particle Datasets Using 3D-to-2D Flexible Fitting based on Molecular Dynamics Simulation	18
Small Molecule Sequestration of the Intrinsically Disordered Protein, p27Kip1, Within Soluble Oligomers	18
CpG Islands Shape the Epigenome Landscape	18
Liquid-liquid Phase Separation in Viral Function	17
Principles of Alternating Access in Multidrug and Toxin Extrusion (MATE) Transporters	17
Machine Learning Methods for Exploring Sequence Determinants of 3D Genome Organization	17
MPTherm-pred: Analysis and Prediction of Thermal Stability Changes upon Mutations in Transmembrane Proteins	17
Metabolic Fate of Human Immunoactive Sterols in Mycobacterium tuberculosis	17
Inhibition of SARS-CoV-2 Infection by Human Defensin HNP1 and Retrocyclin RC-101	17
Identification of Functional Spo0A Residues Critical for Sporulation in Clostridioides difficile	17
Strain Identification and Quantitative Analysis in Microbial Communities	17
Computational Approaches for RNA Structure Ensemble Deconvolution from Structure Probing Data	17
Probing Interdomain Linkers and Protein Supertertiary Structure In Vitro and in Live Cells with Fluorescent Protein Resonance Energy Transfer	17
The Dynamic Influence of Linker Histone Saturation within the Poly-Nucleosome Array	17
Recent Advances in the Structural Biology of Mg2+ Channels and Transporters	17
HSP70, a Novel Regulatory Molecule in B Cell-Mediated Suppression of Autoimmune Diseases	17
Triggering Closure of a Sialic Acid TRAP Transporter Substrate Binding Protein through Binding of Natural or Artificial Substrates	17
Transcriptional and Epigenetic Regulation of Gasdermins	17
Conformational Dynamics Allows Sampling of an “Active-like” State by Oncogenic K-Ras-GDP	17
Hofmeister Ions Modulate the Autocatalytic Amyloidogenesis of an Intrinsically Disordered Functional Amyloid Domain via Unusual Biphasic Kinetics	17
Phosphorylation of the LIR Domain of SCOC Modulates ATG8 Binding Affinity and Specificity	17
Mapping Electromechanical Coupling Pathways in Voltage-Gated Ion Channels: Challenges and the Way Forward	17
PrePPI: A Structure Informed Proteome-wide Database of Protein–Protein Interactions	17
Genetic Code Expansion Through Quadruplet Codon Decoding	17
Line-FRAP, A Versatile Method to Measure Diffusion Rates In Vitro and In Vivo	17
Recent Technologies for Genetic Code Expansion and their Implications on Synthetic Biology Applications	16
Two Bacterial Small Heat Shock Proteins, IbpA and IbpB, Form a Functional Heterodimer	16
Plasma Cells: From Cytokine Production to Regulation in Experimental Autoimmune Encephalomyelitis	16
Charge Segregation in the Intrinsically Disordered Region Governs VRN1 and DNA Liquid-like Phase Separation Robustness	16
AlphaFold: A Special Issue and A Special Time for Protein Science	16
Epithelial Pyroptosis in Host Defense	16
Towards a ‘Spot On’ Understanding of Transcription in the Nucleus	16
TomoFlow: Analysis of Continuous Conformational Variability of Macromolecules in Cryogenic Subtomograms based on 3D Dense Optical Flow	16
BetAware-Deep: An Accurate Web Server for Discrimination and Topology Prediction of Prokaryotic Transmembrane β-barrel Proteins	16
Molecular Mechanisms of Cellular Senescence in Neurodegenerative Diseases	16
Beyond the Nucleosome: Nucleosome-Protein Interactions and Higher Order Chromatin Structure	16
The Role of α-Synuclein in SNARE-mediated Synaptic Vesicle Fusion	16
Effects of N-terminal Acetylation on the Aggregation of Disease-related α-synuclein Variants	16
Cancer-Associated Mutations Perturb the Disordered Ensemble and Interactions of the Intrinsically Disordered p53 Transactivation Domain	16
The DBSAV Database: Predicting Deleteriousness of Single Amino Acid Variations in the Human Proteome	16
Fidelity of Ribonucleotide Incorporation by the SARS-CoV-2 Replication Complex	16
Quantifying the Monomer–Dimer Equilibrium of Tubulin with Mass Photometry	16
The Interplay Between Disordered Regions in RNAs and Proteins Modulates Interactions Within Stress Granules and Processing Bodies	16
An Eight Amino Acid Segment Controls Oligomerization and Preferred Conformation of the two Non-visual Arrestins	16
rMSA: A Sequence Search and Alignment Algorithm to Improve RNA Structure Modeling	16
Inflammasomes in T cells	16
Regulation of E. coli Rep helicase activity by PriC	16
miREV: An Online Database and Tool to Uncover Potential Reference RNAs and Biomarkers in Small-RNA Sequencing Data Sets from Extracellular Vesicles Enriched Samples	16
Unorthodox Mechanisms to Initiate Translation Open Novel Paths for Gene Expression	15
N-terminal Transmembrane-Helix Epitope Tag for X-ray Crystallography and Electron Microscopy of Small Membrane Proteins	15