Journal of Lipid Research

Article	Citations
Bioorthogonal azido-S1P works as substrate for S1PR1	198
Expression of SREBF2 and HMGCR discriminates the viability of steatotic grafts for human liver transplantation	90
Four-dimensional lipidomics profiling in X-linked adrenoleukodystrophy using trapped ion mobility mass spectrometry	82
Plasma S1P and Sphingosine are not Different Prior to Pre-Eclampsia in Women at High Risk of Developing the Disease	68
A simplified method for preventing postmortem alterations of brain prostanoids for true in situ level quantification	61
High cholesterol absorption efficiency increases the risk of the nonfatal and fatal atherosclerotic events	54
Elevation of hepatic de novo lipogenesis in mice with overnutrition is dependent on multiple substrates	53
A Gly-β-muricholic acid and FGF15 combination therapy synergistically reduces “humanized” bile acid pool toxicity in cholestasis mice	47
Specific approaches and limitations in (multi)-omic Mendelian randomization	43
Erratum to: The antidepressant drug sertraline is a novel inhibitor of yeast Pah1 and human lipin 1 phosphatidic acid phosphatases [Journal of Lipid Research 66/1 (2025) 100711]	43
New multiplex LC-MS/MS method for lipid biomarker analysis of inherited neurodegenerative metabolic diseases	38
Functional characterization of 16 variants found in the LDL receptor gene	36
Dietary docosahexaenoic acid (DHA) downregulates liver DHA synthesis by inhibiting eicosapentaenoic acid elongation	36
TMEM241 is a UDP-N-acetylglucosamine transporter required for M6P modification of NPC2 and cholesterol transport	36
Cardiomyopathy in a c.1528G>C Hadha mouse is associated with cardiac tissue lipotoxicity and altered cardiolipin species	33
Cover	31
Measuring Lp(a) particles with a novel isoform-insensitive immunoassay illustrates efficacy of muvalaplin	31
A comprehensive measure of Golgi sphingolipid flux using NBD C6-ceramide: evaluation of sphingolipid inhibitors	30
Altered hepatic lipid droplet morphology and lipid metabolism in fasted Plin2-null mice	29
Generation of hepatoma cell lines deficient in microsomal triglyceride transfer protein	28
The role of lysosomal phospholipase A2 in the catabolism of bis(monoacylglycerol)phosphate and association with phospholipidosis	28
Nuclear lipid droplets in Caco2 cells originate from nascent precursors and in situ at the nuclear envelope	28
In memoriam: Ana Jonas, PhD	27
Creation of a novel zebrafish model with low DHA status to study the role of maternal nutrition during neurodevelopment	27
Dietary modulation of Lp(a): more questions than answers	27

Cover	26
Eicosapentaenoic Acid Ameliorates Cardiac Fibrosis and Tissue Inflammation in Spontaneously Hypertensive Rats	26
Development and application of an LC-MS/MS method for the combined quantification of oxysterols and bile acids	25
The role of high-density lipoproteins in sepsis	25
Widespread but moderate genetic overlap between circulating polyunsaturated fatty acids and brain disorders	25
Cover	25
The adipocyte apolipoprotein M is negatively associated with inflammation	24
Leaflet-specific effects of charged lipids on a voltage-gated potassium channel	24
A fluorogenic substrate for the detection of lipid amidases in intact cells	24
Effect of IL-6R blockade on plasma lipids and clinical outcomes among hospitalized patients with COVID-19 infection	24
METTL3-mediated m6A modification of TNFAIP3 promotes endothelial to mesenchymal transition and atherosclerosis via the NF-κB/SNAIL signaling pathway	23
The n-3 PUFA content of the global lipidomes of NIST SRM 2378, SRM 1950, and intralaboratory quality control materials	23
ABHD4 regulates adipocyte differentiation in vitro but does not affect adipose tissue lipid metabolism in mice	23
Effects of exercise training on ANGPTL3/8 and ANGPTL4/8 and their associations with cardiometabolic traits	22
Choline kinase inhibition promotes ER-phagy	22
Hepatocytes Deficient in Nuclear Envelope Protein Lamina-associated Polypeptide 1 are an Ideal Mammalian System to Study Intranuclear Lipid Droplets	22
Brown adipose tissue facilitates the fever response following infection with Salmonella enterica serovar Typhimurium in mice	22
Introduction of a lipidomics scoring system for data quality assessment	22
Lipidomics and mass spectrometry imaging unveil alterations in mice hippocampus lipid composition exposed to hypoxia	22
The one-key-to-two-doors role of lipidomics: plasma lipidome, cardiovascular risk and statin usage	21
Deep-lipidotyping by mass spectrometry: recent technical advances and applications	21
Highly tail-asymmetric lipids interdigitate and cause bidirectional ordering	20
Diet-induced obesity dampens the temporal oscillation of hepatic mitochondrial lipids	20
Fatty acid nitroalkenes regulate intestinal lipid absorption	20
Cover	20
Dissecting cell type–specific impact in lysosomal acid lipase deficiency–associated disorders	20
In Memoriam: Jan B Sjövall, MD, PhD, (1928–2024)	20
Asprosin as a regulator of hepatic lipogenesis and its association with hepatic steatosis	20
The role of N-terminal phosphorylation of DGK-θ	20
Efficacy of a novel PCSK9 inhibitory peptide alone and with evinacumab in a mouse model of atherosclerosis	19
Hepatic Deletion of X-Box Binding Protein 1 in FXR Null Mice Leads to Enhanced Liver Injury	19
2-Hydroxypropyl-β-cyclodextrin mitigates pathological changes in a mouse model of retinal cholesterol dyshomeostasis	19
Detergent-induced quantitatively limited formation of diacyl phosphatidylinositol dimannoside in Mycobacterium smegmatis	19
Characterizing genetic profiles for high triglyceride levels in U.S. patients of African ancestry	19
Resolving versus non-resolving sphingolipid dynamics during macrophage activation: a time-resolved metabolic analysis	19
Elevated high-density lipoprotein triglycerides increase atherosclerotic risk	19
KLF7 induced ADRB3-dependent IL-6 production in brown adipocytes during stress	19
TLR4 in POMC neurons regulates thermogenesis in a sex-dependent manner	19
Metabolic switch from glycogen to lipid in the liver maintains glucose homeostasis in neonatal mice	18
DFCP1 is a regulator of starvation-driven ATGL-mediated lipid droplet lipolysis	18
Cover	18
Apolipoprotein A5 reduces clearance of VLDL by altering apolipoprotein E content	18
Saroglitazar is noninferior to fenofibrate in reducing triglyceride levels in hypertriglyceridemic patients in a randomized clinical trial	18
Polyunsaturated fatty acids stimulate immunity and eicosanoid production in Drosophila melanogaster	18
Mitochondrial cardiolipin remodeling facilitates efficient myoblast differentiation	18
Carnitine deficiency alters fuel metabolism and voluntary wheel running in mice	18
Elevated n-3/n-6 PUFA ratio in early life diet reverses adverse intrauterine kidney programming in female rats	17
Apolipoprotein A1 and high-density lipoprotein limit low-density lipoprotein transcytosis by binding SR-B1	17
Repurposing daclatasvir for MASLD Therapy—A promising step forward with challenges ahead	17
A facile assay for zDHHC palmitoyl transferase activation elucidates effects of mutation and modification	17

Phosphatidic Acid Mediates the Nem1-Spo7/Pah1 Phosphatase Cascade in Yeast Lipid Synthesis	17
Phosphatidylserine-decorated delivery platform helps alleviate acute lung injury via potentiating macrophage targeting	17
Cover	17
Glucosylceramide flippases contribute to cellular glucosylceramide homeostasis	17
Analytical validation of a direct lipoprotein(a)-cholesterol assay	17
Circadian PER1 controls daily fat absorption with the regulation of PER1-PKA on phosphorylation of bile acid synthetase	17
EBF2 regulates cardiolipin and phosphatidylethanolamine remodeling and mitochondrial dynamics in brown fat	17
Lipidomic analysis of Porphyromonas gingivalis reveals novel glycerol bisphosphoceramide, phosphatidyl-, and phosphoglycerol dipeptide lipid families	16
Decreased sarcoplasmic reticulum phospholipids in human skeletal muscle are associated with metabolic syndrome	16
Mice deficient in ER protein seipin have reduced adrenal cholesteryl ester lipid droplet formation and utilization	16
Cover	16
Tripartite motif 38 alleviates the pathological process of NAFLD–NASH by promoting TAB2 degradation	16
Associations between serum cholesterol and immunophenotypical characteristics of circulatory B cells and Tregs	16
Metallothionein 1B attenuates inflammation and hepatic steatosis in MASH by inhibiting the AKT/PI3K pathway	16
In vivo visualization of lipophagy dynamics using the tfLiveDrop reporter mice	16
HBV-miR-3 induces hepatic cholesterol accumulation by targeting ABCA1: Evidence for potential benefits of statin usage	16
Heptanol-mediated phase separation determines phase preference of molecules in live cell membranes	16
High-density lipoproteins mediate small RNA intercellular communication between dendritic cells and macrophages	16
Spatial lipidomics of coronary atherosclerotic plaque development in a familial hypercholesterolemia swine model	16
Liver X Receptor Agonists Enhances Intestinal Repair in Neonatal Piglets with Massive Bowel Resection	15
Association of plasma ceramide with decline in kidney function in patients with type 2 diabetes	15
Alveolar type 2 cell LRP1 is needed for surfactant phospholipid metabolism and pulmonary function in mice	15
Disruption of nucleotide biosynthesis reprograms mitochondrial metabolism to inhibit adipogenesis	15
NEGR1 deficiency disrupts lipid metabolism and steroidogenesis in Leydig cells, linking testosterone to behavior	15
Individual and simultaneous treatment with antipsychotic aripiprazole and antidepressant trazodone inhibit sterol biosynthesis in the adult brain	15
ORMDL mislocalization by impaired autophagy in Niemann-Pick type C disease leads to increased de novo sphingolipid biosynthesis	15
An integrative approach to studying sphingolipid metabolism reveals p53 as a master regulator of the pathway	15
Microbial products linked to steatohepatitis are reduced by deletion of nuclear hormone receptor SHP in mice	15
Combining ASBT inhibitor and FGF15 treatments enhances therapeutic efficacy against cholangiopathy in female but not male Cyp2c70 KO mice	15
Cover	15
Cardiolipin remodeling maintains the inner mitochondrial membrane in cells with saturated lipidomes	15
Dysregulation of mitochondrial dynamics and mitophagy are involved in high-fat diet-induced steroidogenesis inhibition	15
GCKIII kinases control hepatocellular lipid homeostasis via shared mode of action	15
Detecting white adipose tissue browning in mice with in vivo R2∗ mapping at 9.4T MRI	15
Alternative fatty acid desaturation pathways revealed by deep profiling of total fatty acids in RAW 264.7 cell line	15
Lipidation as a post-translational code for protein liquid-liquid phase separation	14
Herring roe PLs promote SPM biosynthesis in macrophages and a keratinocyte/fibroblast coculture as a model of psoriasis	14
Cover	14
Triglyceride-rich lipoprotein, remnant cholesterol, and apolipoproteins CII, CIII, and E in patients with schizophrenia	14
Comprehensive mass spectrometry lipidomics of human biofluids and ocular tissues	14
Participation of lipids in the tumor response to photodynamic therapy and its exploitation for therapeutic gain	14
Cover	14
Liver proteomics identifies a disconnect between proteins associated with de novo lipogenesis and triglyceride storage	14
Reducing saturated fat intake lowers LDL-C but increases Lp(a) levels in African Americans: the GET-READI feeding trial	14
Untargeted lipidomics reveals novel HDL metabotypes and lipid-clinical correlates	14
Quantitative characterizations of the cholesterol-related pathways in the retina and brain of hamsters	14
Causal association of blood lipids with all-cause and cause-specific mortality risk: a Mendelian randomization study	14
Measurement of 7-dehydrocholesterol and cholesterol in hair can be used in the diagnosis of Smith-Lemli-Opitz syndrome	14
Spatial mapping of PUFA incorporation into phospholipids with bisallylic deuteration	13
Substrate-dependent incorporation of 15-lipoxygenase products in glycerophospholipids: 15-HETE and 15-HEPE in PI, 17-HDHA in plasmalogen PE, and 13-HODE in PC	13
Sorting through the extensive and confusing roles of sortilin in metabolic disease	13
Differential expression patterns of phospholipase D isoforms 1 and 2 in the mammalian brain and retina	13
Endothelial SR-B1 is dispensable for thermogenesis but promotes selective cholesterol uptake in brown adipose tissue	13
Characteristic distribution of eicosapentaenoic acid in human abdominal aortic aneurysm wall	13
Unraveling the genetic background of individuals with a clinical familial hypercholesterolemia phenotype	13
APOA5 deficiency causes hypertriglyceridemia by reducing amounts of lipoprotein lipase in capillaries	13
A multi-ancestry genome-wide association study and evaluation of polygenic scores of LDL-C levels	13
Oleate activates PLD2 lipase and GEF activity by modulating membrane microdomain dynamics via S-acylation	13
De(C1P)hering the role of ceramide-1-phosphate levels in skin wound healing	13
Lipid and lipoprotein metabolism in microglia: Alzheimer’s disease mechanisms and interventions	13
Longitudinal analysis of lipid changes in the sciatic nerve caused by overexpression of PMP22 in murine models of CMT1A	13
Distinct pathways for the absorption and metabolism of β-carotene and zeaxanthin in the mouse intestine	13
LPLAT7 Reutilizes Unsaturated 1-Lysophospholipids Formed During Lysosomal Phospholipid Degradation	13
Hsp90α promotes lipogenesis by stabilizing FASN and promoting FASN transcription via LXRα in hepatocellular carcinoma	13
Magnetic resonance imaging detects white adipose tissue beiging in mice following PDE10A inhibitor treatment	13
Cover	13
Strategies for consistent and automated quantification of HDL proteome using data-independent acquisition	13
Competitive displacement of lipoprotein lipase from heparan sulfate is orchestrated by a disordered acidic cluster in GPIHBP1	13
6-O-alkyl 4-methylumbelliferyl-β-D-glucosides as selective substrates for GBA1 in the discovery of glycosylated sterols	13
The association between early pregnancy maternal lipid indicators with gestational diabetes mellitus and pre-eclampsia	13
The lipidomics reporting checklist a framework for transparency of lipidomic experiments and repurposing resource data	12
Unveiling novel macrophage-specific biomarkers in MASH through single-cell sequencing for diagnostic modeling	12
The Non Catalytic Protein ERG28 has a Functional Role in Cholesterol Synthesis and is Coregulated Transcriptionally	12
Blocking Lipid Uptake Pathways Does not Prevent Toxicity in Adipose Triglyceride Lipase (ATGL) Deficiency	12
Mitochondria-specific photorelease of ceramide induces apoptosis	12
Effects of apolipoprotein H downregulation on lipid metabolism, fatty liver disease, and gut microbiota dysbiosis	12
Intestinal colonization of germ-free mice with indole-producing E. coli modulates the central and peripheral endocannabinoidome	12
Sphingomyelin is involved in regulating UCP1-mediated nonshivering thermogenesis	12
Potential causal evidence for an ApoB-independent and HDL-related risk profile associated with coronary artery disease	12
Unbiased insights into the multiplicity of the CYP46A1 brain effects in 5XFAD mice treated with low dose-efavirenz	12

Insulin dysregulation drives mitochondrial cholesterol metabolite accumulation: initiating hepatic toxicity in nonalcoholic fatty liver disease	12
Targeting to high density lipoprotein cholesterol: new insights for inflammatory bowel disease treatment	12
Peridroplet mitochondria are associated with the severity of MASLD and the prevention of MASLD by diethyldithiocarbamate	12
Maternal DHA intake in mice increased DHA metabolites in the pup brain and ameliorated MeHg-induced behavioral disorder	12
Brown fat fuels the fire in fever	12
Adipose Tissue, Bile Acids, and Gut Microbiome Species Associated With Gallstones After Bariatric Surgery	12
Global deletion of COX-2 attenuates hepatic inflammation but impairs metabolic homeostasis in diet-induced obesity	12
The DNA methyltransferase inhibitor decitabine blunts the response to a high-animal fat and protein diet in mice	11
Vascular lipid droplets formed in response to TNF, hypoxia, or OA: biochemical composition and prostacyclin generation	11
Mining cholesterol genes from thousands of mouse livers identifies aldolase C as a regulator of cholesterol biosynthesis	11
Circulating membrane aminophospholipids contribute to thrombotic risk in rheumatoid arthritis	11
Pioglitazone alleviates lacrimal gland impairments induced by high-fat diet by suppressing M1 polarization	11
Pharmacological SERCA activation limits diet-induced steatohepatitis and restores liver metabolic function in mice	11
Decoding the role of angiopoietin-like protein 4/8 complex–mediated plasmin generation in the regulation of LPL activity	11
A historical, evidence-based, and narrative review on commonly used dietary supplements in lipid-lowering	11
A high-cholesterol zebrafish diet promotes hypercholesterolemia and fasting-associated liver steatosis	11
Cover	11
Cover	11
Flavonoids regulate LDLR through different mechanisms tied to their specific structures	11
Loss of Splicing Factor SRSF3 Impairs Lipophagy Through Ubiquitination and Degradation of Syntaxin17 in Hepatocytes	11
Aggressive cholesterol lowering normalizes atherosclerosis regression in Jak2 mice	11
Cover	11
Associations between insulin-like growth factor binding protein-2 and lipoprotein kinetics in men	11
SDCCAG3 inhibits adipocyte hypertrophy and improves obesity-related metabolic disorders via SDCCAG3/SMURF1/PPARγ axis	11
Acute retinol mobilization by retinol-binding protein 4 in mouse liver induces fibroblast growth factor 21 expression	10
Relationship of apolipoprotein(a) isoform size with clearance and production of lipoprotein(a) in a diverse cohort	10
In Memoriam: G. Stephen (Steve) Tint, PhD (1935–2022)	10
A novel mutation, Ile344Asn, in microsomal triglyceride transfer protein abolishes binding to protein disulfide isomerase	10
WITHDRAWN: The Risk of Going Outside: Amino Phospholipids in Rheumatoid Arthritis	10
Seipin expression in hepatocytes impairs the assembly of VLDLs and exacerbates steatohepatitis	10
The sphingosine kinase 2 inhibitors ABC294640 and K145 elevate (dihydro)sphingosine 1-phosphate levels in various cells	10
LC-MS based simultaneous profiling of adrenal hormones of steroids, catecholamines, and metanephrines	10
Determination of tissue contributions to the circulating lipid pool in cold exposure via systematic assessment of lipid profiles	10
Specific FAHFAs predict worsening glucose tolerance in non-diabetic relatives of people with Type 2 diabetes	10
2-fluoro-1-methylpyridinium p-toluene sulfonate: a new LC-MS/MS derivatization reagent for vitamin D metabolites	10
Cover	10
Dietary phospholipid carriers of DHA do not increase brain DHA levels: a replication study	10
The antidepressant drug sertraline is a novel inhibitor of yeast Pah1 and human lipin 1 phosphatidic acid phosphatases	10
JNK1 mediates serine phosphorylation of STAT3 in response to fatty acids released by lipolysis	10
Spatial lipidomics reveals zone-specific hepatic lipid alteration and remodeling in metabolic dysfunction-associated steatohepatitis	10
Plasma lipidomics and 15-year risk of incident diabetes: a coronary artery risk development in young adults study	10
Unmasking crucial residues in adipose triglyceride lipase for coactivation with comparative gene identification-58	10
All-trans retinoic acid induces lipophagy by reducing Rubicon in Hepa1c1c7 cells	10
A targeted proteomics method for quantifying plasma apolipoprotein kinetics in individual mice using stable isotope labeling	10
Lipidomics of phospholipase A2 reveals exquisite specificity in macrophages	10
Hydrogen gas with hypothermic machine perfusion induces lipidomic alterations in donation-after-cardiac-death rat livers	10
Sphingosine kinase 1 is involved in triglyceride breakdown by maintaining lysosomal integrity in brown adipocytes	10
Elovl4b knockout zebrafish as a model for ocular very-long-chain PUFA deficiency	10
A high-resolution 13C NMR approach for profiling fatty acid unsaturation in lipid extracts and in live Caenorhabditis elegans	9
Sphinganine as a potentially relevant metabolite in pulmonary involvement of primary Sjögren’s syndrome	9
Hexokinase 2 promotes ISGylation of Acyl-CoA synthetase long-chain family member 4 in sepsis-induced microglia cells	9
Total oxylipin concentrations in NIST SRM 1950 plasma compared to fresh and commercially obtained human plasma	9
Effect of type 2 diabetes on the inducible degrader of LDL receptor	9
Does small HDL’s function improve when lipid-lowering alters its composition?	9
A basic model for the association of ligands with membrane cholesterol: application to cytolysin binding	9
Potential causal and temporal relationship between plasma triglyceride levels and circulating leukocyte	9
Peroxisomal ether-glycerophospholipid synthesis is dysregulated after TBI	9
Changes in soluble LDL receptor and lipoprotein fractions in response to diet in the DIETFITS weight loss study	9
17,18-epoxyeicosatetraenoic acid ameliorates mRNA-LNP–induced local inflammation by inhibiting neutrophil infiltration	9
Human apoA-I[Lys107del] mutation affects lipid surface behavior of apoA-I and its ability to form large nascent HDL	9
Phospholipase A2 products influence the antiplatelet functions of synthetic high-density lipoproteins	9
Inositol acylation of phosphatidylinositol mannosides: a rapid mass response to membrane fluidization in mycobacteria	9
Cover	9
Genetic deletion or pharmacologic inhibition of the Nlrp3 inflammasome did not ameliorate experimental NASH	8
Deducing formation routes of oxylipins by quantitative multiple heart-cutting achiral-chiral 2D-LC-MS	8
ASTER-B regulates mitochondrial carotenoid transport and homeostasis	8
Mammarenaviruses depend on endogenous fatty acid synthesis in cell culture systems	8
Oxylipin composition of high-density lipoprotein is altered in men and Hispanic adults with mild cognitive impairment	8
High Sensitivity and Wide Linearity LC-MS/MS Method for Oxylipin Quantification in Multiple Biological Samples	8
Effects of coconut oil, olive oil, and butter on plasma fatty acids and metabolic risk factors: a randomized trial	8
Correction: Unmasking crucial residues in adipose triglyceride lipase for coactivation with comparative gene identification-58	8
Unveiling the role of Mfsd2a and LPC-DHA in kidney repair	8
ANGPTL4/8 promotes plasmin-mediated cleavage of LPL inhibitors	8
1-Deoxysphingolipid synthesis compromises anchorage-independent growth and plasma membrane endocytosis in cancer cells	8
Conjugated bile acids are elevated in severe calcific aortic valve stenosis	8
Whole picture of human stratum corneum ceramides, including the chain-length diversity of long-chain bases	8
Modeling enzyme competition in eicosanoid metabolism in macrophage cells using a cybernetic framework	8
S-nitrosylation contributes to ER stress and aggresome formation in secosterol-B-mediated endothelial dysfunction	8
Toxoplasma acyl-CoA synthetase TgACS3 is crucial to channel host fatty acids in lipid droplets and for parasite propagation	8
Bioactive lipid mediators in plasma are predictors of preeclampsia irrespective of aspirin therapy	8
Gly-β-MCA is a potent anti-cholestasis agent against “human-like” hydrophobic bile acid-induced biliary injury in mice	8
Microbe-derived cyclopropane lipids activate host nuclear receptors	8
Visualize neuronal membrane cholesterol with split-fluorescent protein tagged YDQA sensor	8
Sulfatide with ceramide composed of phytosphingosine (t18:0) and 2-hydroxy FAs in renal intercalated cells	8
Modification in mitochondrial function is associated with the FADS1 variant and its interaction with alpha-linolenic acid-enriched diet—An exploratory study	8
Ichthyosis linked to sphingosine 1-phosphate lyase insufficiency is due to aberrant sphingolipid and calcium regulation	8
Cholesteryl hemiazelate identified in CVD patients causes in vitro and in vivo inflammation	8
Insights into the molecular changes of adipocyte dedifferentiation and its future research opportunities	8
Integrated lipidomic and proteomic profiling reveals metabolic network disruption by SARS-CoV-2 variants	8
Analysis of omega-3 and omega-6 polyunsaturated fatty acid metabolism by compound-specific isotope analysis in humans	8
Helminth-induced prostaglandin signaling and dietary shifts in PUFA metabolism promote colitis-associated cancer	8
HDL meets triglyceride	8
Novel odd-chain cyclopropane fatty acids: detection in a mammalian lipidome and uptake by hepatosplanchnic tissues	7
CD14loCD301b+ macrophages gathering as a proangiogenic marker in adipose tissues	7
Dysregulated ceramide metabolism in mouse progressive dermatitis resulting from constitutive activation of Jak1	7