Journal of Lipid Research

Article	Citations
Generation of hepatoma cell lines deficient in microsomal triglyceride transfer protein	184
Bioorthogonal azido-S1P works as substrate for S1PR1	153
Functional characterization of 16 variants found in the LDL receptor gene	78
Cardiomyopathy in a c.1528G>C Hadha mouse is associated with cardiac tissue lipotoxicity and altered cardiolipin species	66
A simplified method for preventing postmortem alterations of brain prostanoids for true in situ level quantification	58
Expression of SREBF2 and HMGCR discriminates the viability of steatotic grafts for human liver transplantation	58
TMEM241 is a UDP-N-acetylglucosamine transporter required for M6P modification of NPC2 and cholesterol transport	54
Plasma S1P and Sphingosine are not Different Prior to Pre-Eclampsia in Women at High Risk of Developing the Disease	53
Erratum to: The antidepressant drug sertraline is a novel inhibitor of yeast Pah1 and human lipin 1 phosphatidic acid phosphatases [Journal of Lipid Research 66/1 (2025) 100711]	52
Specific approaches and limitations in (multi)-omic Mendelian randomization	49
Altered hepatic lipid droplet morphology and lipid metabolism in fasted Plin2-null mice	43
Elevation of hepatic de novo lipogenesis in mice with overnutrition is dependent on multiple substrates	43
A comprehensive measure of Golgi sphingolipid flux using NBD C6-ceramide: evaluation of sphingolipid inhibitors	41
The role of lysosomal phospholipase A2 in the catabolism of bis(monoacylglycerol)phosphate and association with phospholipidosis	37
Development of a novel spatiotemporal depletion system for cellular cholesterol	35
Nuclear lipid droplets in Caco2 cells originate from nascent precursors and in situ at the nuclear envelope	35
A Gly-β-muricholic acid and FGF15 combination therapy synergistically reduces “humanized” bile acid pool toxicity in cholestasis mice	32
Measuring Lp(a) particles with a novel isoform-insensitive immunoassay illustrates efficacy of muvalaplin	30
New Multiplex LC-MS/MS Method for lipid biomarker Analysis of Inherited Neurodegenerative Metabolic Diseases	29
High cholesterol absorption efficiency increases the risk of the nonfatal and fatal atherosclerotic events	28
Four-dimensional lipidomics profiling in X-linked adrenoleukodystrophy using trapped ion mobility mass spectrometry	28
Dietary docosahexaenoic acid (DHA) downregulates liver DHA synthesis by inhibiting eicosapentaenoic acid elongation	27
In memoriam: Ana Jonas, PhD	27
Development and application of an LC-MS/MS method for the combined quantification of oxysterols and bile acids	26
Dietary modulation of Lp(a): more questions than answers	26

A fluorogenic substrate for the detection of lipid amidases in intact cells	25
Cover	25
The one-key-to-two-doors role of lipidomics: plasma lipidome, cardiovascular risk and statin usage	24
Cover	24
The role of high-density lipoproteins in sepsis	23
Effect of IL-6R blockade on plasma lipids and clinical outcomes among hospitalized patients with COVID-19 infection	23
The adipocyte apolipoprotein M is negatively associated with inflammation	23
Widespread but moderate genetic overlap between circulating polyunsaturated fatty acids and brain disorders	22
Effects of exercise training on ANGPTL3/8 and ANGPTL4/8 and their associations with cardiometabolic traits	21
Eicosapentaenoic Acid Ameliorates Cardiac Fibrosis and Tissue Inflammation in Spontaneously Hypertensive Rats	21
Hepatocytes Deficient in Nuclear Envelope Protein Lamina-associated Polypeptide 1 are an Ideal Mammalian System to Study Intranuclear Lipid Droplets	21
Lipidomics and mass spectrometry imaging unveil alterations in mice hippocampus lipid composition exposed to hypoxia	21
Brown adipose tissue facilitates the fever response following infection with Salmonella enterica serovar Typhimurium in mice	21
KIAA1363 affects retinyl ester turnover in cultured murine and human hepatic stellate cells	21
METTL3-mediated m6A modification of TNFAIP3 promotes endothelial to mesenchymal transition and atherosclerosis via the NF-κB/SNAIL signaling pathway	20
Creation of a novel zebrafish model with low DHA status to study the role of maternal nutrition during neurodevelopment	20
ABHD4 regulates adipocyte differentiation in vitro but does not affect adipose tissue lipid metabolism in mice	20
Leaflet-specific effects of charged lipids on a voltage-gated potassium channel	20
Choline kinase inhibition promotes ER-phagy	20
Fatty acid nitroalkenes regulate intestinal lipid absorption	19
The n-3 PUFA content of the global lipidomes of NIST SRM 2378, SRM 1950 and intra-laboratory quality control materials	19
In Memoriam: Jan B Sjövall, MD, PhD, (1928–2024)	19
Deep-lipidotyping by mass spectrometry: recent technical advances and applications	19
DFCP1 is a regulator of starvation-driven ATGL-mediated lipid droplet lipolysis	19
Introduction of a lipidomics scoring system for data quality assessment	19
Elevated high-density lipoprotein triglycerides increase atherosclerotic risk	18
Cover	18
Corrigendum to Small molecule inducers of ABCA1 and apoE that act through indirect activation of the LXR pathway	18
Highly tail-asymmetric lipids interdigitate and cause bidirectional ordering	18
Efficacy of a novel PCSK9 inhibitory peptide alone and with evinacumab in a mouse model of atherosclerosis	18
Dissecting cell type–specific impact in lysosomal acid lipase deficiency–associated disorders	17
Apolipoprotein A5 reduces clearance of VLDL by altering apolipoprotein E content	17
TLR4 in POMC neurons regulates thermogenesis in a sex-dependent manner	17
Detergent-induced quantitatively limited formation of diacyl phosphatidylinositol dimannoside in Mycobacterium smegmatis	17
Polyunsaturated fatty acids stimulate immunity and eicosanoid production in Drosophila melanogaster	17
Saroglitazar is noninferior to fenofibrate in reducing triglyceride levels in hypertriglyceridemic patients in a randomized clinical trial	17
Resolving versus non-resolving sphingolipid dynamics during macrophage activation: a time-resolved metabolic analysis	17
2-Hydroxypropyl-β-cyclodextrin mitigates pathological changes in a mouse model of retinal cholesterol dyshomeostasis	17
Mitochondrial cardiolipin remodeling facilitates efficient myoblast differentiation	17
Characterizing genetic profiles for high triglyceride levels in U.S. patients of African ancestry	17
Diet-induced obesity dampens the temporal oscillation of hepatic mitochondrial lipids	17
Metabolic switch from glycogen to lipid in the liver maintains glucose homeostasis in neonatal mice	16
Repurposing daclatasvir for MASLD Therapy—A promising step forward with challenges ahead	16
Mice deficient in ER protein seipin have reduced adrenal cholesteryl ester lipid droplet formation and utilization	16
Cover	16
The role of N-terminal phosphorylation of DGK-θ	16
Cover	16
Asprosin as a regulator of hepatic lipogenesis and its association with hepatic steatosis	16
Phosphatidylserine-decorated delivery platform helps alleviate acute lung injury via potentiating macrophage targeting	16
Lipidomic analysis of Porphyromonas gingivalis reveals novel glycerol bisphosphoceramide, phosphatidyl-, and phosphoglycerol dipeptide lipid families	16

Hepatic Deletion of X-Box Binding Protein 1 in FXR Null Mice Leads to Enhanced Liver Injury	16
Elevated n-3/n-6 PUFA ratio in early life diet reverses adverse intrauterine kidney programming in female rats	16
Heptanol-mediated phase separation determines phase preference of molecules in live cell membranes	16
Glucosylceramide flippases contribute to cellular glucosylceramide homeostasis	16
EBF2 regulates cardiolipin and phosphatidylethanolamine remodeling and mitochondrial dynamics in brown fat	15
Circadian PER1 controls daily fat absorption with the regulation of PER1-PKA on phosphorylation of bile acid synthetase	15
Phosphatidic Acid Mediates the Nem1-Spo7/Pah1 Phosphatase Cascade in Yeast Lipid Synthesis	15
Associations between serum cholesterol and immunophenotypical characteristics of circulatory B cells and Tregs	15
Apolipoprotein A1 and high-density lipoprotein limit low-density lipoprotein transcytosis by binding SR-B1	15
Quantitative characterizations of the cholesterol-related pathways in the retina and brain of hamsters	14
A facile assay for zDHHC palmitoyl transferase activation elucidates effects of mutation and modification	14
Association of plasma ceramide with decline in kidney function in patients with type 2 diabetes	14
HBV-miR-3 induces hepatic cholesterol accumulation by targeting ABCA1: Evidence for potential benefits of statin usage	14
Metallothionein 1B attenuates inflammation and hepatic steatosis in MASH by inhibiting the AKT/PI3K pathway	14
High-density lipoproteins mediate small RNA intercellular communication between dendritic cells and macrophages	14
Decreased sarcoplasmic reticulum phospholipids in human skeletal muscle are associated with metabolic syndrome	14
Spatial lipidomics of coronary atherosclerotic plaque development in a familial hypercholesterolemia swine model	14
ORMDL mislocalization by impaired autophagy in Niemann-Pick type C disease leads to increased de novo sphingolipid biosynthesis	14
Dysregulation of mitochondrial dynamics and mitophagy are involved in high-fat diet-induced steroidogenesis inhibition	14
Cardiolipin remodeling maintains the inner mitochondrial membrane in cells with saturated lipidomes	14
Consequences of excessive glucosylsphingosine in glucocerebrosidase-deficient zebrafish.	14
GCKIII kinases control hepatocellular lipid homeostasis via shared mode of action	14
Cover	14
Intravital lipid droplet labeling and imaging reveals the phenotypes and functions of individual macrophages in vivo	14
Tripartite motif 38 alleviates the pathological process of NAFLD–NASH by promoting TAB2 degradation	14
Detecting white adipose tissue browning in mice with in vivo R2∗ mapping at 9.4T MRI	13
Cover	13
Participation of lipids in the tumor response to photodynamic therapy and its exploitation for therapeutic gain	13
Triglyceride-rich lipoprotein, remnant cholesterol, and apolipoproteins CII, CIII, and E in patients with schizophrenia	13
Combining ASBT inhibitor and FGF15 treatments enhances therapeutic efficacy against cholangiopathy in female but not male Cyp2c70 KO mice	13
Individual and simultaneous treatment with antipsychotic aripiprazole and antidepressant trazodone inhibit sterol biosynthesis in the adult brain	13
Comprehensive mass spectrometry lipidomics of human biofluids and ocular tissues	13
Liver proteomics identifies a disconnect between proteins associated with de novo lipogenesis and triglyceride storage	13
Cover	13
Alternative fatty acid desaturation pathways revealed by deep profiling of total fatty acids in RAW 264.7 cell line	13
Measurement of 7-dehydrocholesterol and cholesterol in hair can be used in the diagnosis of Smith-Lemli-Opitz syndrome	13
Disruption of nucleotide biosynthesis reprograms mitochondrial metabolism to inhibit adipogenesis	13
NEGR1 deficiency disrupts lipid metabolism and steroidogenesis in Leydig cells, linking testosterone to behavior	13
Cover	13
Reducing saturated fat intake lowers LDL-C but increases Lp(a) levels in African Americans: the GET-READI feeding trial	13
Cover	13
Untargeted lipidomics reveals novel HDL metabotypes and lipid-clinical correlates	13
Microbial products linked to steatohepatitis are reduced by deletion of nuclear hormone receptor SHP in mice	13
Causal association of blood lipids with all-cause and cause-specific mortality risk: a Mendelian randomization study	13
APOA5 deficiency causes hypertriglyceridemia by reducing amounts of lipoprotein lipase in capillaries	12
Distinct pathways for the absorption and metabolism of β-carotene and zeaxanthin in the mouse intestine	12
A multi-ancestry genome-wide association study and evaluation of polygenic scores of LDL-C levels	12
Lipid and lipoprotein metabolism in microglia: Alzheimer’s disease mechanisms and interventions	12
Unraveling the genetic background of individuals with a clinical familial hypercholesterolemia phenotype	12
De(C1P)hering the role of ceramide-1-phosphate levels in skin wound healing	12
Hsp90α promotes lipogenesis by stabilizing FASN and promoting FASN transcription via LXRα in hepatocellular carcinoma	12
Substrate-dependent incorporation of 15-lipoxygenase products in glycerophospholipids: 15-HETE and 15-HEPE in PI, 17-HDHA in plasmalogen PE, and 13-HODE in PC	12
The association between early pregnancy maternal lipid indicators with gestational diabetes mellitus and pre-eclampsia	12
Sorting through the extensive and confusing roles of sortilin in metabolic disease	12
Strategies for consistent and automated quantification of HDL proteome using data-independent acquisition	12
Endothelial SR-B1 is dispensable for thermogenesis but promotes selective cholesterol uptake in brown adipose tissue	12
Comparison between genetic and pharmaceutical disruption of Ldlr expression for the development of atherosclerosis	12
Hormone-sensitive lipase protects adipose triglyceride lipase-deficient mice from lethal lipotoxic cardiomyopathy	12
Oleate activates PLD2 lipase and GEF activity by modulating membrane microdomain dynamics via S-acylation	12
Differential expression patterns of phospholipase D isoforms 1 and 2 in the mammalian brain and retina	12
Unbiased insights into the multiplicity of the CYP46A1 brain effects in 5XFAD mice treated with low dose-efavirenz	11
Global deletion of COX-2 attenuates hepatic inflammation but impairs metabolic homeostasis in diet-induced obesity	11
Potential causal evidence for an ApoB-independent and HDL-related risk profile associated with coronary artery disease	11
Magnetic resonance imaging detects white adipose tissue beiging in mice following PDE10A inhibitor treatment	11
Peridroplet mitochondria are associated with the severity of MASLD and the prevention of MASLD by diethyldithiocarbamate	11
Characteristic distribution of eicosapentaenoic acid in human abdominal aortic aneurysm wall	11
Competitive displacement of lipoprotein lipase from heparan sulfate is orchestrated by a disordered acidic cluster in GPIHBP1	11
The lipidomics reporting checklist a framework for transparency of lipidomic experiments and repurposing resource data	11
6-O-alkyl 4-methylumbelliferyl-β-D-glucosides as selective substrates for GBA1 in the discovery of glycosylated sterols	11
Brown fat fuels the fire in fever	11
Blocking Lipid Uptake Pathways Does not Prevent Toxicity in Adipose Triglyceride Lipase (ATGL) Deficiency	11
The Non Catalytic Protein ERG28 has a Functional Role in Cholesterol Synthesis and is Coregulated Transcriptionally	11
Adipose Tissue, Bile Acids, and Gut Microbiome Species Associated With Gallstones After Bariatric Surgery	11
Insulin dysregulation drives mitochondrial cholesterol metabolite accumulation: initiating hepatic toxicity in nonalcoholic fatty liver disease	11
Targeting to high density lipoprotein cholesterol: new insights for inflammatory bowel disease treatment	11
Mitochondria-specific photorelease of ceramide induces apoptosis	11
Spatial Mapping of PUFA Incorporation into Phospholipids with bisallylic deuteration	11
Ceramide kinase regulates acute wound healing by suppressing 5-oxo-ETE biosynthesis and signaling via its receptor OXER1	11
Maternal DHA intake in mice increased DHA metabolites in the pup brain and ameliorated MeHg-induced behavioral disorder	11
Decoding the role of angiopoietin-like protein 4/8 complex–mediated plasmin generation in the regulation of LPL activity	10

The DNA methyltransferase inhibitor decitabine blunts the response to a high-animal fat and protein diet in mice	10
Pioglitazone alleviates lacrimal gland impairments induced by high-fat diet by suppressing M1 polarization	10
Associations between insulin-like growth factor binding protein-2 and lipoprotein kinetics in men	10
Vascular lipid droplets formed in response to TNF, hypoxia, or OA: biochemical composition and prostacyclin generation	10
A targeted proteomics method for quantifying plasma apolipoprotein kinetics in individual mice using stable isotope labeling	10
Pharmacological SERCA activation limits diet-induced steatohepatitis and restores liver metabolic function in mice	10
Effects of apolipoprotein H downregulation on lipid metabolism, fatty liver disease, and gut microbiota dysbiosis	10
SDCCAG3 inhibits adipocyte hypertrophy and improves obesity-related metabolic disorders via SDCCAG3/SMURF1/PPARγ axis	10
Mining cholesterol genes from thousands of mouse livers identifies aldolase C as a regulator of cholesterol biosynthesis	10
Sphingomyelin is involved in regulating UCP1-mediated nonshivering thermogenesis	10
A novel mutation, Ile344Asn, in microsomal triglyceride transfer protein abolishes binding to protein disulfide isomerase	10
In Memoriam: G. Stephen (Steve) Tint, PhD (1935–2022)	10
A high-cholesterol zebrafish diet promotes hypercholesterolemia and fasting-associated liver steatosis	10
The SGLT2 inhibitor dapagliflozin promotes systemic FFA mobilization, enhances hepatic β-oxidation, and induces ketosis	10
Loss of Splicing Factor SRSF3 Impairs Lipophagy Through Ubiquitination and Degradation of Syntaxin17 in Hepatocytes	10
Flavonoids regulate LDLR through different mechanisms tied to their specific structures	10
A historical, evidence-based, and narrative review on commonly used dietary supplements in lipid-lowering	10
Cover	10
Cover	10
All-trans retinoic acid induces lipophagy by reducing Rubicon in Hepa1c1c7 cells	10
Unmasking crucial residues in adipose triglyceride lipase for coactivation with comparative gene identification-58	9
Circulating membrane aminophospholipids contribute to thrombotic risk in rheumatoid arthritis	9
WITHDRAWN: The Risk of Going Outside: Amino Phospholipids in Rheumatoid Arthritis	9
2-fluoro-1-methylpyridinium p-toluene sulfonate: a new LC-MS/MS derivatization reagent for vitamin D metabolites	9
A basic model for the association of ligands with membrane cholesterol: application to cytolysin binding	9
Maternal obesogenic diet enhances cholestatic liver disease in offspring	9
Spatial lipidomics reveals zone-specific hepatic lipid alteration and remodeling in metabolic dysfunction-associated steatohepatitis	9
Acute retinol mobilization by retinol-binding protein 4 in mouse liver induces fibroblast growth factor 21 expression	9
Cover	9
Dietary phospholipid carriers of DHA do not increase brain DHA levels: a replication study	9
Sphingosine kinase 1 is involved in triglyceride breakdown by maintaining lysosomal integrity in brown adipocytes	9
The antidepressant drug sertraline is a novel inhibitor of yeast Pah1 and human lipin 1 phosphatidic acid phosphatases	9
Does small HDL’s function improve when lipid-lowering alters its composition?	9
Lipidomics of phospholipase A2 reveals exquisite specificity in macrophages	9
Potential causal and temporal relationship between plasma triglyceride levels and circulating leukocyte	9
Relationship of apolipoprotein(a) isoform size with clearance and production of lipoprotein(a) in a diverse cohort	9
Determination of tissue contributions to the circulating lipid pool in cold exposure via systematic assessment of lipid profiles	9
Apolipoprotein F concentration, activity, and the properties of LDL controlling ApoF activation in hyperlipidemic plasma	9
Specific FAHFAs predict worsening glucose tolerance in non-diabetic relatives of people with Type 2 diabetes	9
Inositol acylation of phosphatidylinositol mannosides: a rapid mass response to membrane fluidization in mycobacteria	9
LC-MS based simultaneous profiling of adrenal hormones of steroids, catecholamines, and metanephrines	9
Cover	8
Analysis of omega-3 and omega-6 polyunsaturated fatty acid metabolism by compound-specific isotope analysis in humans	8
Chronic cholesterol depletion increases F-actin levels and induces cytoskeletal reorganization via a dual mechanism	8
Sphinganine as a potentially relevant metabolite in pulmonary involvement of primary Sjögren’s syndrome	8
Human apoA-I[Lys107del] mutation affects lipid surface behavior of apoA-I and its ability to form large nascent HDL	8
Hexokinase 2 promotes ISGylation of Acyl-CoA synthetase long-chain family member 4 in sepsis-induced microglia cells	8
Correction: Unmasking crucial residues in adipose triglyceride lipase for coactivation with comparative gene identification-58	8
Effect of type 2 diabetes on the inducible degrader of LDL receptor	8
Bioactive lipid mediators in plasma are predictors of preeclampsia irrespective of aspirin therapy	8
Sulfatide with ceramide composed of phytosphingosine (t18:0) and 2-hydroxy FAs in renal intercalated cells	8
1-Deoxysphinganine initiates adaptive responses to serine and glycine starvation in cancer cells via proteolysis of sphingosine kinase	8
The sphingosine kinase 2 inhibitors ABC294640 and K145 elevate (dihydro)sphingosine 1-phosphate levels in various cells	8
Elovl4b knockout zebrafish as a model for ocular very-long-chain PUFA deficiency	8
Changes in soluble LDL receptor and lipoprotein fractions in response to diet in the DIETFITS weight loss study	8
Cover	8
Integrated lipidomic and proteomic profiling reveals metabolic network disruption by SARS-CoV-2 variants	8
Peroxisomal ether-glycerophospholipid synthesis is dysregulated after TBI	8
Phospholipase A2 Products Influence the Antiplatelet Functions of Synthetic High-Density Lipoproteins	8
A high-resolution 13C NMR approach for profiling fatty acid unsaturation in lipid extracts and in live Caenorhabditis elegans	8
17,18-epoxyeicosatetraenoic acid ameliorates mRNA-LNP–induced local inflammation by inhibiting neutrophil infiltration	8
Effects of coconut oil, olive oil, and butter on plasma fatty acids and metabolic risk factors: a randomized trial	7
High Sensitivity and Wide Linearity LC-MS/MS Method for Oxylipin Quantification in Multiple Biological Samples	7
ASTER-B regulates mitochondrial carotenoid transport and homeostasis	7
MUSTN1 and FABP3 interact to regulate adipogenesis and lipid deposition	7
Toxoplasma acyl-CoA synthetase TgACS3 is crucial to channel host fatty acids in lipid droplets and for parasite propagation	7
Cover	7
Whole picture of human stratum corneum ceramides, including the chain-length diversity of long-chain bases	7
Cholesterol sulfate fluidizes the sterol fraction of the stratum corneum lipid phase and increases its permeability	7
Genetic deletion or pharmacologic inhibition of the Nlrp3 inflammasome did not ameliorate experimental NASH	7
Ichthyosis linked to sphingosine 1-phosphate lyase insufficiency is due to aberrant sphingolipid and calcium regulation	7
Insights into the molecular changes of adipocyte dedifferentiation and its future research opportunities	7
Visualize neuronal membrane cholesterol with split-fluorescent protein tagged YDQA sensor	7
Modification in mitochondrial function is associated with the FADS1 variant and its interaction with alpha-linolenic acid-enriched diet—An exploratory study	7
A fatty acid-ordered plasma membrane environment is critical for Ebola virus matrix protein assembly and budding	7
Cover	7
Modeling enzyme competition in eicosanoid metabolism in macrophage cells using a cybernetic framework	7
Deducing formation routes of oxylipins by quantitative multiple heart-cutting achiral-chiral 2D-LC-MS	7
Gly-β-MCA is a potent anti-cholestasis agent against “human-like” hydrophobic bile acid-induced biliary injury in mice	7
Microbe-derived cyclopropane lipids activate host nuclear receptors	7
Cholesteryl hemiazelate identified in CVD patients causes in vitro and in vivo inflammation	7
Helminth-induced prostaglandin signaling and dietary shifts in PUFA metabolism promote colitis-associated cancer	7
ANGPTL4/8 promotes plasmin-mediated cleavage of LPL inhibitors	7
Unveiling the role of Mfsd2a and LPC-DHA in kidney repair	7
Resolvin D2/GPR 18 axis ameliorates pressure overload-induced heart failure by inhibiting pro-inflammatory macrophage polarization	7
Cover	7
1-Deoxysphingolipid synthesis compromises anchorage-independent growth and plasma membrane endocytosis in cancer cells	7
Corrigendum to: Functional characterization of missense variants affecting the extracellular domains of ABCA1 using a fluorescence-based assay [Journal of Lipid Research 65/1 (2024) 100482]	7
Loss of plasma membrane lipid asymmetry can induce ordered domain (raft) formation	7
HDL meets triglyceride	7
Phosphatidylthreonine is a procoagulant lipid detected in human blood and elevated in coronary artery disease	6
SCD4 deficiency decreases cardiac steatosis and prevents cardiac remodeling in mice fed a high-fat diet	6
Oxidized phospholipids cause changes in jejunum mucus that induce dysbiosis and systemic inflammation	6
Identification of plasma proteins binding oxidized phospholipids using pull-down proteomics and OxLDL masking assay	6
Stromal cell-derived NGF controls sympathetic innervation in subcutaneous fat	6