OOIR: Observatory of International Research

Papers

(The TQCC of Journal of General Physiology is 6. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-02-01 to 2025-02-01.)

Article	Citations
Sinus node dysfunction in heart failure is characterized by reduced CaMKII signaling	58
Regional differences in arrhythmogenesis	50
Further progress in understanding of myofibrillar function in health and disease	39
Cardiac mechanical efficiency is preserved in primary cardiac hypertrophy despite impaired mechanical function	36
Spliced isoforms of the cardiac Nav1.5 channel modify channel activation by distinct structural mechanisms	35
Understanding the role of mutations in voltage-gated sodium ion channels for cardiovascular disorders	31
Role of ryanodine receptor 2 and FK506-binding protein 12.6 dissociation in pulmonary hypertension	30
On the molecular mechanism of excitation–transcription coupling in skeletal muscle	30
Interplay of Nav1.8 and Nav1.7 channels drives neuronal hyperexcitability in neuropathic pain	30
Phosphorylation of RyR2 simultaneously expands the dyad and rearranges the tetramers	29
Fifty years of gating currents and channel gating	27
Fluorescence lifetime-based assay reports structural changes in cardiac muscle mediated by effectors of contractile regulation	25
Fragmentation and roles of junctophilin1 in muscle of patients with cytosolic leak of stored calcium	24
Implication of CREB in the calcium regulation by ischemia/reperfusion in cardiomyocytes	24
What FXYDs fix	23
Cardiac MyBP-C phosphorylation regulates the Frank–Starling relationship in murine hearts	21
Mutant D96V calmodulin induces unexpected remodeling of cardiac nanostructure and physiology	21
Acute exposure to extracellular BTP2 does not inhibit Ca2+ release during EC coupling in intact skeletal muscle fibers	19
Evaluating sequential and allosteric activation models in IKs channels with mutated voltage sensors	19
Mutation of a conserved glutamine residue does not abolish desensitization of acid-sensing ion channel 1	19
Electro-metabolic signaling	18
Mutations in proteins involved in E-C coupling and SOCE and congenital myopathies	18
Titin–N2A: More than a signaling node?	18
Interrogating the gating motions of the NaK channel	18
Unraveling the mysteries of the titin–N2A signalosome	18

X-ray irradiation triggers immune response in human T-lymphocytes via store-operated Ca2+ entry and NFAT activation	17
Determinants of iFGF13-mediated regulation of myocardial voltage-gated sodium (NaV) channels in mouse	16
Cold and warmth intensify pain-linked sodium channel gating effects and persistent currents	16
Differential regulation of cardiac sodium channels by intracellular fibroblast growth factors	16
An Ala/Glu difference in E1 of Cx26 and Cx30 contributes to their differential anionic permeabilities	16
CaV1.3 L-type Ca2+ channel modulates pancreatic β-cell electrical activity and survival	15
BK channel modulation by positively charged peptides and auxiliary γ subunits mediated by the Ca2+-bowl site	15
Sarcomere length affects Ca2+ sensitivity of contraction in ischemic but not non-ischemic myocardium	15
Fluorescence labeling strategies for cell surface expression of TRPV1	15
Effects of HOCl oxidation on excitation–contraction coupling: Implications for the pathophysiology of Duchenne muscular dystrophy	15
From α1s splicing to γ1 function: A new twist in subunit modulation of the skeletal muscle L-type Ca2+ channel	14
Real-time observation of functional specialization among phosphorylation sites in CFTR	14
Machine learning meets Monte Carlo methods for models of muscle’s molecular machinery to classify mutations	14
Kv1.1 channels help set the pace	14
The spatial distribution of glycogen and glycogen consumption in muscle cells	14
Why make a strong muscle weaker?	13
The fast block to polyspermy breaks with convention	13
Discovery of new intracellular junctions: The calcium entry units (CEUs)	13
Mice with R2509C-RYR1 mutation exhibit dysfunctional Ca2+ dynamics in primary skeletal myocytes	12
Elucidating the clandestine behavior of enantiomeric DHPs in calcium channels	12
The surprising difficulty of “simple” equilibrium binding measurements on ligand-gated ion channels	12
How can AI accelerate advances in physiology?	12
Cooperative mechanisms underlie differences in myocardial contractile dynamics between large and small mammals	12
Probenecid affects muscle Ca2+ homeostasis and contraction independently from pannexin channel block	12
The biophysical properties of TRIC-A and TRIC-B and their interactions with RyR2	12
Ion channels of cold transduction and transmission	12
Calcium binding and permeation in TRPV channels: Insights from molecular dynamics simulations	11
TMEM16A activation for the fast block to polyspermy in the African clawed frog does not require conventional activation of egg PLCs	11
Directing two-way traffic in the kidney: A tale of two ions	11
Muscle ankyrin repeat protein 1 (MARP1) locks titin to the sarcomeric thin filament and is a passive force regulator	11
Role of a conserved ion-binding site tyrosine in ion selectivity of the Na+/K+ pump	11
Artificial intelligence approaches to the volumetric quantification of glycogen granules in EM images of human tissue	11
The versatile regulation of K2P channels by polyanionic lipids of the phosphoinositide and fatty acid metabolism	10
The zinc-binding motif of TRPM7 acts as an oxidative stress sensor to regulate its channel activity	10
Anionic omega currents from single countercharge mutants in the voltage-sensing domain of Ci-VSP	10
Identification of PUFA interaction sites on the cardiac potassium channel KCNQ1	10
PACAP and acetylcholine cause distinct Ca2+ signals and secretory responses in chromaffin cells	10
Grammotoxin increases its toxic behavior	10
Mechanisms of dihydropyridine agonists and antagonists in view of cryo-EM structures of calcium and sodium channels	10
Cardiomyopathic mutations in essential light chain reveal mechanisms regulating the super relaxed state of myosin	10
Remodeled connexin 43 hemichannels alter cardiac excitability and promote arrhythmias	10
The epithelial potassium channel Kir7.1 is stimulated by progesterone	10
The structural and functional integrities of porcine myocardium are mostly preserved by cryopreservation	9
Gating of RYR2 channels from the arrhythmic RYR2-P2328S mouse heart and some unexpected actions of flecainide	9
Conformational changes linked to ADP release from human cardiac myosin bound to actin-tropomyosin	9
Protein functional dynamics from the rigorous global analysis of DEER data: Conditions, components, and conformations	9
Filament evanescence of myosin II and smooth muscle function	9
Structural determinants of acid-sensing ion channel potentiation by single chain lipids	9
Depolarization-induced bursts of miniature synaptic currents in individual synapses of developing cerebellum	9
Disorder in Ca2+ release unit locations confers robustness but cuts flexibility of heart pacemaking	9

Molecular rearrangements in S6 during slow inactivation in Shaker-IR potassium channels	8
Depressed myocardial cross-bridge cycling kinetics in a female guinea pig model of diastolic heart failure	8
Gating pore currents occur in CaV1.1 domain III mutants associated with HypoPP	8
Extracellular mechanotransduction	8
EVAP: A two-photon imaging tool to study conformational changes in endogenous Kv2 channels in live tissues	8
Calcium current modulation by the γ1 subunit depends on alternative splicing of CaV1.1	8
Eccentric contraction-induced strength loss in dystrophin-deficient muscle: Preparations, protocols, and mechanisms	8
About hysteresis in Shaker: A note on Cowgill and Chanda	8
Voltage sensor movements of CaV1.1 during an action potential in skeletal muscle fibers	8
CaV1.1 defects in hypokalemic periodic paralysis and harnessing multiple approaches for therapeutic intervention	8
Myosin and tropomyosin–troponin complementarily regulate thermal activation of muscles	8
Shaker-IR K+ channel gating in heavy water: Role of structural water molecules in inactivation	8
cMyBPC phosphorylation alters response to heart failure drug	7
Species dependent cardiac electrophysiological effects elicited by various potassium channel blocking drugs	7
Extracellular histone proteins activate P2XR7 channel current	7
Analogs of FTY720 inhibit TRPM7 but not S1PRs and exert multimodal anti-inflammatory effects	7
A strategy for determining the equilibrium constants for heteromeric ion channels in a complex model	7
Toward an understanding of myofibrillar function in health and disease	7
Direct cardiotoxicity of lead	7
Cardiomyocyte sarcomere length variability: Membrane fluorescence versus second harmonic generation myosin imaging	7
Superfast excitation–contraction coupling in adult zebrafish skeletal muscle fibers	7
Mechanisms underlying dilated cardiomyopathy associated with FKBP12 deficiency	7
A Kv2 inhibitor traps itself in place	7
X rays activate T cell calcium signaling	7
GPCR signaling is highly compartmentalized in human cardiomyocytes and severely remodeled in atrial fibrillation	7
Mechanosensitive channel MscS is critical for termination of the bacterial hypoosmotic permeability response	7
Burmese pythons exhibit a transient adaptation to nutrient overload that prevents liver damage	7
Mechanism of external K+ sensitivity of KCNQ1 channels	7
Resin-acid derivatives bind to multiple sites on the voltage-sensor domain of the Shaker potassium channel	6
Reconstituting depolarization-induced calcium release	6
How PKA helps cardiomyocytes Navigate chronic stress	6
Nociceptor sodium channels shape subthreshold phase, upstroke, and shoulder of action potentials	6
ANO1, CaV1.2, and IP3R form a localized unit of EC-coupling in mouse pulmonary arterial smooth muscle	6
Q-cubed mutant cues clues to CLC antiport mechanism	6
Sarcomere length in the beating heart: Synchronicity is optional	6
Tirasemtiv enhances submaximal muscle tension in an Acta1:p.Asp286Gly mouse model of nemaline myopathy	6
Lower troponin expression in the right ventricle of rats explains interventricular differences in E–C coupling	6
Acute exposure to the chemotherapy cisplatin has a biphasic effect in cardiac contractility	6
Therapeutic effects of novel type 1 ryanodine receptor inhibitor on malignant hyperthermia	6
How do batrachotoxin-bearing frogs and birds avoid self intoxication?	6
Neuronal KCNQ2/3 channels are recruited to lipid raft microdomains by palmitoylation of BACE1	6
Niclosamide potentiates TMEM16A and induces vasoconstriction	6