OOIR: Observatory of International Research

Papers

(The TQCC of Journal of General Physiology is 6. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-05-01 to 2025-05-01.)

Article	Citations
Implication of CREB in the calcium regulation by ischemia/reperfusion in cardiomyocytes	65
Mutation of a conserved glutamine residue does not abolish desensitization of acid-sensing ion channel 1	43
Unraveling the mysteries of the titin–N2A signalosome	38
Anionic omega currents from single countercharge mutants in the voltage-sensing domain of Ci-VSP	38
Mutations in proteins involved in E-C coupling and SOCE and congenital myopathies	36
Role of ryanodine receptor 2 and FK506-binding protein 12.6 dissociation in pulmonary hypertension	35
Interrogating the gating motions of the NaK channel	32
Further progress in understanding of myofibrillar function in health and disease	30
Kv1.1 channels help set the pace	28
Machine learning meets Monte Carlo methods for models of muscle’s molecular machinery to classify mutations	28
The epithelial potassium channel Kir7.1 is stimulated by progesterone	26
Differential state-dependent Nav1.8 inhibition by suzetrigine, LTGO-33, and A-887826	26
Spliced isoforms of the cardiac Nav1.5 channel modify channel activation by distinct structural mechanisms	26
EVAP: A two-photon imaging tool to study conformational changes in endogenous Kv2 channels in live tissues	24
Gating pore currents occur in CaV1.1 domain III mutants associated with HypoPP	23
Mechanism of external K+ sensitivity of KCNQ1 channels	22
Hippocampal neurons maintain a large PtdIns(4)P pool that results in faster PtdIns(4,5)P2 synthesis	22
The funny current If is essential for the fight-or-flight response in cardiac pacemaker cells	22
Superfast excitation–contraction coupling in adult zebrafish skeletal muscle fibers	21
Niclosamide potentiates TMEM16A and induces vasoconstriction	20
ANO1, CaV1.2, and IP3R form a localized unit of EC-coupling in mouse pulmonary arterial smooth muscle	20
Correction: A mathematical model to quantify RYR Ca2+ leak and associated heat production in resting human skeletal muscle fibers	20
Stochastic force generation in an isometric binary mechanical system	20
Reconstituting depolarization-induced calcium release	19
Regulation of NMDAR activation efficiency by environmental factors and subunit composition	18

Variants of the myosin interacting-heads motif	18
Light induces a rapid increase in cAMP and activates PKA in rod outer segments of the frog retina	18
How do batrachotoxin-bearing frogs and birds avoid self intoxication?	17
Mitochondrial morphology governs ATP production rate	16
Distinct properties and activation of hexameric and heptameric Pannexin 1 channel concatemers	16
Blood flow-bearing physical forces, endothelial glycocalyx, and liver enzyme mobilization: A hypothesis	16
Increased basal metabolic rate in mice susceptible to malignant hyperthermia and heat stroke	16
Pannexin-1 and CaV1.1 show reciprocal interaction during excitation–contraction and excitation–transcription coupling in skeletal muscle	15
Nerve-dependent distribution of subsynaptic type 1 inositol 1,4,5-trisphosphate receptor at the neuromuscular junction	15
Piezo2 interacts with E-cadherin in specialized gastrointestinal epithelial mechanoreceptors	15
Connecting the dots on connexin function	15
Myosin-binding protein-H: Not just filler	15
Orai1 as a potential “fits-all approach” therapeutic target for the treatment of DMD	15
Segregation of Ca2+ signaling in olfactory signal transduction	15
Mechanism of hydrophobic gating in the acetylcholine receptor channel pore	15
Why are you talking with snakes? To get new evolutionary insights in cardiac electrophysiology!	14
About hysteresis in Shaker: Response to note by Villalba-Galea	14
Examination of conformational dynamics of AdiC transporter with fluorescence-polarization microscopy	13
Probenecid affects sarcoplasmic reticulum Ca2+ release and depresses contractile activation in mouse skeletal muscle	13
Piezo1 is a mechanosensor channel in CNS capillaries	13
Recordings of action potentials, charge movements, and sarcoplasmic reticulum Ca2+ release in isolated adult zebrafish fast skeletal muscle fibers reveals very fast kinetics of excitation–contraction	13
L-type channel inactivation balances the increased peak calcium current due to absence of Rad in cardiomyocytes	12
A complete set of rate constants for a transporter’s catalytic cycle	12
Null method to estimate the maximal PA at subsaturating concentrations of agonist	12
Expression of ENaC subunits in epithelia	12
A non-transmembrane channel formed by Ca2+-bound calsequestrin-2	12
Cooling intact and demembranated trabeculae from rat heart releases myosin motors from their inhibited conformation	11
BK channels of five different subunit combinations underlie the de novo KCNMA1 G375R channelopathy	11
Mechanistic understanding of KCNQ1 activating polyunsaturated fatty acid analogs	11
Probing function in ligand-gated ion channels without measuring ion transport	11
Allosteric modulation of GluN1/GluN3 NMDA receptors by GluN1-selective competitive antagonists	11
Blockade of TRPV channels by intracellular spermine	11
Na+/Ca2+ exchange in enamel cells is dominated by the K+-dependent NCKX exchanger	11
Acid-sensing ion channel 1a activates IKCa/SKCa channels and contributes to endothelium-dependent dilation	11
Myosin’s powerstroke transitions define atomic scale movement of cardiac thin filament tropomyosin	10
A sodium channel mutant removes fast inactivation with the inactivation particle bound	10
Dependence of myosin filament structure on intracellular calcium concentration in skeletal muscle	10
EAAT5 glutamate transporter rapidly binds glutamate with micromolar affinity in mouse rods	10
Arrhythmogenesis in heart cells involves reverse E–C coupling and reverse electrotonic conduction along T-tubules	10
Possible mechanisms underlying the dynamic assembly of calcium entry units: The role of temperature and pH	10
Molecular mechanism of claudin-15 strand flexibility: A computational study	10
Worms find PEZO-1’s function easy to swallow	10
Molecular mechanisms responsible for the sexual dimorphism in pancreatic β-cell insulin release	10
Cooperative binding ensures the obligatory melibiose/Na+ cotransport in MelB	9
CaMKII inhibition reduces arrhythmogenic Ca2+ events in subendocardial cryoinjured rat living myocardial slices	9
Multiscale molecular dynamics simulations predict arachidonic acid binding sites in human ASIC1a and ASIC3 transmembrane domains	9
Asymmetric contribution of a selectivity filter gate in triggering inactivation of CaV1.3 channels	9
A novel method for determining murine skeletal muscle fiber type using autofluorescence lifetimes	9
Reduced plasticity and microtubule densification in muscular dystrophy-related cardiomyopathy	9
A high-throughput electrophysiology assay to study the response of PIEZO1 to mechanical stimulation	9

How a tyrosine primes the pump	9
Sodium channel subpopulations with distinct biophysical properties and subcellular localization enhance cardiac conduction	9
Intrinsic contractile dysfunction in a surgical model of muscle hypertrophy	9
Cardiac mechanical efficiency is preserved in primary cardiac hypertrophy despite impaired mechanical function	8
Screening for bilayer-active and likely cytotoxic molecules reveals bilayer-mediated regulation of cell function	8
Differential regulation of cardiac sodium channels by intracellular fibroblast growth factors	8
The speed of the hair cell mechanotransducer channel revealed by fluctuation analysis	8
Cardiomyopathic mutations in essential light chain reveal mechanisms regulating the super relaxed state of myosin	8
Probenecid affects muscle Ca2+ homeostasis and contraction independently from pannexin channel block	8
Phosphorylation of RyR2 simultaneously expands the dyad and rearranges the tetramers	8
Heart failure in mice induces a dysfunction of the sinus node associated with reduced CaMKII signaling	8
Directing two-way traffic in the kidney: A tale of two ions	8
Huntington’s disease skeletal muscle has altered T-tubules	8
Evaluating sequential and allosteric activation models in IKs channels with mutated voltage sensors	8
The zinc-binding motif of TRPM7 acts as an oxidative stress sensor to regulate its channel activity	8
Blue flash sheds light on the roles of individual phosphoserines in CFTR channel activation	8
Fragmentation and roles of junctophilin1 in muscle of patients with cytosolic leak of stored calcium	8
Angiotensin 1–7 prevents the excessive force loss resulting from 14- and 28-day denervation in mouse EDL and soleus muscle	8
Fifty years of gating currents and channel gating	8
Mechanisms of dihydropyridine agonists and antagonists in view of cryo-EM structures of calcium and sodium channels	8
GPCR signaling is highly compartmentalized in human cardiomyocytes and severely remodeled in atrial fibrillation	8
Neuronal KCNQ2/3 channels are recruited to lipid raft microdomains by palmitoylation of BACE1	7
Structural basis for severe pain caused by mutations in the voltage sensors of sodium channel NaV1.7	7
Species dependent cardiac electrophysiological effects elicited by various potassium channel blocking drugs	7
Lower troponin expression in the right ventricle of rats explains interventricular differences in E–C coupling	7
The S1 helix is a VIP in VSP	7
Mechanistic insights on KATP channel regulation from cryo-EM structures	7
Acute exposure to the chemotherapy cisplatin has a biphasic effect in cardiac contractility	7
The physical basis of osmosis	7
Fusion pore flux controls the rise-times of quantal synaptic responses	7
Voltage sensor movements of CaV1.1 during an action potential in skeletal muscle fibers	7
Nociceptor sodium channels shape subthreshold phase, upstroke, and shoulder of action potentials	7
Burmese pythons exhibit a transient adaptation to nutrient overload that prevents liver damage	7
Mechanisms underlying dilated cardiomyopathy associated with FKBP12 deficiency	7
The Cranefield Awards 2022	6
A novel Hv1 inhibitor reveals a new mechanism of inhibition of a voltage-sensing domain	6
2022	6
Essential role of Orai1 and SARAF in vascular remodeling	6
Examining the calcium sensitivity of skeletal muscle thick filaments	6
State-dependent inhibition of BK channels by the opioid agonist loperamide	6
HIFs: New arginine mimic inhibitors of the Hv1 channel with improved VSD–ligand interactions	6
Dantrolene inhibition of ryanodine channels (RyR2) in artificial lipid bilayers depends on FKBP12.6	6
Rad protein: An essential player in L-type Ca2+ channel localization and modulation in cardiomyocytes	6
Lifetime of autofluorescence: A novel method to determine murine skeletal muscle fiber types	6
The action of Con-ikot-ikot toxin on single AMPA-type glutamate receptors	6
Physical activity impacts resting skeletal muscle myosin conformation and lowers its ATP consumption	6
ON and OFF starburst amacrine cells are controlled by distinct cholinergic pathways	6
Insect elementary calcium release events measured in honeybee muscle cells	6