OOIR: Observatory of International Research

Papers

(The TQCC of Journal of General Physiology is 8. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-08-01 to 2026-08-01.)

Article	Citations
Interrogating the gating motions of the NaK channel	65
Mutations in proteins involved in E-C coupling and SOCE and congenital myopathies	54
Voltage-sensor gating charge interactions bimodally regulate voltage dependence and kinetics of calcium channel activation	51
Anionic omega currents from single countercharge mutants in the voltage-sensing domain of Ci-VSP	45
Machine learning meets Monte Carlo methods for models of muscle’s molecular machinery to classify mutations	41
Differential state-dependent Nav1.8 inhibition by suzetrigine, LTGO-33, and A-887826	36
Investigating the role of the I–II linker in Nav1.5 channel function	33
NALCN/Cch1 channelosome subunits originated in early eukaryotes	33
Kv1.1 channels help set the pace	31
Reconstituting depolarization-induced calcium release	31
Variants of the myosin interacting-heads motif	28
Stochastic force generation in an isometric binary mechanical system	27
The funny current If is essential for the fight-or-flight response in cardiac pacemaker cells	27
Altered NaV1.9 channel activity in two Tyr66Ser variant carriers with small fiber dysfunction	27
Distinct properties and activation of hexameric and heptameric Pannexin 1 channel concatemers	25
Niclosamide potentiates TMEM16A and induces vasoconstriction	25
Regulation of NMDAR activation efficiency by environmental factors and subunit composition	24
The relationship between apparent potentiation and the magnitude of the control response	23
Differential regulation of β1-dependent voltage shifts and kinetic modulation by an extracellular glutamate in NaV1.6 VSDIV	22
ANO1, CaV1.2, and IP3R form a localized unit of EC-coupling in mouse pulmonary arterial smooth muscle	22
Beat-locked ATP microdomains in the sinoatrial node map a Ca2+-timed energetic hierarchy and regional pacemaker roles	20
Mechanism of external K+ sensitivity of KCNQ1 channels	20
Light induces a rapid increase in cAMP and activates PKA in rod outer segments of the frog retina	20
Coincidence detection supported by electrical synapses is shaped by the D-type K+ current	19
Orai1 as a potential “fits-all approach” therapeutic target for the treatment of DMD	19

About hysteresis in Shaker: Response to note by Villalba-Galea	19
Examination of conformational dynamics of AdiC transporter with fluorescence-polarization microscopy	19
Nerve-dependent distribution of subsynaptic type 1 inositol 1,4,5-trisphosphate receptor at the neuromuscular junction	19
Mitochondrial morphology governs ATP production rate	19
Connecting the dots on connexin function	18
Myosin-binding protein-H: Not just filler	18
Blood flow-bearing physical forces, endothelial glycocalyx, and liver enzyme mobilization: A hypothesis	18
Segregation of Ca2+ signaling in olfactory signal transduction	18
Piezo2 interacts with E-cadherin in specialized gastrointestinal epithelial mechanoreceptors	17
Mechanism of hydrophobic gating in the acetylcholine receptor channel pore	17
A primer on the methods of skeletal and cardiac muscle mechanics using permeabilized preparations	16
Na+/Ca2+ exchange in enamel cells is dominated by the K+-dependent NCKX exchanger	16
Molecular mechanism of claudin-15 strand flexibility: A computational study	16
Kinetic reconstruction of graded membrane excitability in Paramecium	16
Expression of ENaC subunits in epithelia	16
Acid-sensing ion channel 1a activates IKCa/SKCa channels and contributes to endothelium-dependent dilation	16
Null method to estimate the maximal PA at subsaturating concentrations of agonist	16
Mechanistic understanding of KCNQ1 activating polyunsaturated fatty acid analogs	15
Allosteric modulation of GluN1/GluN3 NMDA receptors by GluN1-selective competitive antagonists	15
Blockade of TRPV channels by intracellular spermine	15
Myosin’s powerstroke transitions define atomic scale movement of cardiac thin filament tropomyosin	15
A complete set of rate constants for a transporter’s catalytic cycle	14
EAAT5 glutamate transporter rapidly binds glutamate with micromolar affinity in mouse rods	14
BK channels of five different subunit combinations underlie the de novo KCNMA1 G375R channelopathy	14
Asymmetric contribution of a selectivity filter gate in triggering inactivation of CaV1.3 channels	13
Variability in reported midpoints of (in)activation of cardiac INa	13
Sodium channel subpopulations with distinct biophysical properties and subcellular localization enhance cardiac conduction	13
A sodium channel mutant removes fast inactivation with the inactivation particle bound	13
A high-throughput electrophysiology assay to study the response of PIEZO1 to mechanical stimulation	13
Diminished gap junction coupling under diabetogenic conditions does not drive loss of functional β-cell subpopulations	12
Screening for bilayer-active and likely cytotoxic molecules reveals bilayer-mediated regulation of cell function	12
Blue flash sheds light on the roles of individual phosphoserines in CFTR channel activation	12
Multiscale molecular dynamics simulations predict arachidonic acid binding sites in human ASIC1a and ASIC3 transmembrane domains	12
Myosin-binding protein H-like nonsense variants exhibit impaired sarcomere incorporation and alter contractility	12
Vesicular monoamine transporters (VMATs): From discovery to therapeutic targets	12
Subunit composition of the KATP channels that modulate contractility of skeletal muscle during fatigue	12
Dependence of myosin filament structure on intracellular calcium concentration in skeletal muscle	12
GRIN2B disease-associated mutations disrupt the function of BK channels and NMDA receptor signaling nanodomains	12
Trouble in store for muscle fibers	12
Directing two-way traffic in the kidney: A tale of two ions	12
Differential regulation of cardiac sodium channels by intracellular fibroblast growth factors	11
Probenecid affects muscle Ca2+ homeostasis and contraction independently from pannexin channel block	11
Glycerol storage increases passive stiffness of muscle fibers through effects on titin extensibility	11
Evaluating sequential and allosteric activation models in I Ks channels with mutated voltage sensors	11
Mechanisms of dihydropyridine agonists and antagonists in view of cryo-EM structures of calcium and sodium channels	11
Mechanistic insights on KATP channel regulation from cryo-EM structures	11
Phosphorylation of RyR2 simultaneously expands the dyad and rearranges the tetramers	11
Fifty years of gating currents and channel gating	11
Molecular dynamics analyses of CLDN15 pore size and charge selectivity	11
Mechanisms underlying dilated cardiomyopathy associated with FKBP12 deficiency	11

Regulation of voltage-sensing structures of CaV1.2 calcium channel by the auxiliary β3-subunit	10
The physical basis of osmosis	10
The S1 helix is a VIP in VSP	10
Distinctive mechanical response characteristics of the guinea pig apical cochlear organ of Corti and basilar membrane	10
Mind the midpoints: Rethinking variability in cardiac INa	10
Subtype-selective targeting of NMDA receptors—A potent new compound emerges	10
Brain voltage-gated Ca2+ channels and calmodulin: Teaming up in calmodulinopathies?	10
Examining the calcium sensitivity of skeletal muscle thick filaments	10
Fusion pore flux controls the rise-times of quantal synaptic responses	10
Nociceptor sodium channels shape subthreshold phase, upstroke, and shoulder of action potentials	10
Structural basis for severe pain caused by mutations in the voltage sensors of sodium channel NaV1.7	9
Giving structure meaning: Modelling the cellular synapse of excitation–contraction coupling in skeletal muscle	9
The Cranefield Awards 2022	9
Phosphoinositide regulation of voltage-gated sodium channels	9
Physical activity impacts resting skeletal muscle myosin conformation and lowers its ATP consumption	9
Manganese and intracellular Ca2+ handling	9
Will the real KATP please stand up? Kir6.2/SUR2A takes the stand in the tiring case of skeletal muscle fatigue	9
How the Blind Watchmaker messed around with potassium channels	8
Rad protein: An essential player in L-type Ca2+ channel localization and modulation in cardiomyocytes	8
Binding motif for RIC-3 chaperon protein in serotonin type 3A receptors	8
Opening of rod photoreceptor CNG channels by photodynamically generated singlet oxygen	8
Exploring voltage-gated sodium channel conformations and protein–protein interactions using AlphaFold2	8
Dual regulation of Kv7.2/7.3 channels by long-chain n-alcohols	8
Regulation of olfactory chloride and cyclic nucleotide–gated channels by cholesterol	8
A realistic look at rod synapses	8
ON and OFF starburst amacrine cells are controlled by distinct cholinergic pathways	8
A reconstituted depolarization-induced Ca2+ release platform for validation of skeletal muscle disease mutations and drug discovery	8
Titin’s P-zone domains A164–167 are essential for thick filament structural arrangement	8
Inhibition of CaV1.4 channels by CaV3 channel antagonists ML218 and Z944	8
Cardiomyocyte ryanodine receptor clusters expand and coalesce after application of isoproterenol	8