OOIR: Observatory of International Research

Papers

(The TQCC of Journal of General Physiology is 8. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-12-01 to 2025-12-01.)

Article	Citations
Anionic omega currents from single countercharge mutants in the voltage-sensing domain of Ci-VSP	79
NALCN/Cch1 channelosome subunits originated in early eukaryotes	45
Investigating the role of the I–II linker in Nav1.5 channel function	45
Interrogating the gating motions of the NaK channel	41
Kv1.1 channels help set the pace	38
Spliced isoforms of the cardiac Nav1.5 channel modify channel activation by distinct structural mechanisms	37
Machine learning meets Monte Carlo methods for models of muscle’s molecular machinery to classify mutations	32
Differential state-dependent Nav1.8 inhibition by suzetrigine, LTGO-33, and A-887826	24
Voltage-sensor gating charge interactions bimodally regulate voltage dependence and kinetics of calcium channel activation	23
Mutations in proteins involved in E-C coupling and SOCE and congenital myopathies	23
Role of ryanodine receptor 2 and FK506-binding protein 12.6 dissociation in pulmonary hypertension	23
Correction: A mathematical model to quantify RYR Ca2+ leak and associated heat production in resting human skeletal muscle fibers	23
Variants of the myosin interacting-heads motif	22
Stochastic force generation in an isometric binary mechanical system	22
Reconstituting depolarization-induced calcium release	22
Altered NaV1.9 channel activity in two Tyr66Ser variant carriers with small fiber dysfunction	21
ANO1, CaV1.2, and IP3R form a localized unit of EC-coupling in mouse pulmonary arterial smooth muscle	21
Light induces a rapid increase in cAMP and activates PKA in rod outer segments of the frog retina	20
Distinct properties and activation of hexameric and heptameric Pannexin 1 channel concatemers	20
Mechanism of external K+ sensitivity of KCNQ1 channels	20
Hippocampal neurons maintain a large PtdIns(4)P pool that results in faster PtdIns(4,5)P2 synthesis	19
Superfast excitation–contraction coupling in adult zebrafish skeletal muscle fibers	19
Segregation of Ca2+ signaling in olfactory signal transduction	18
Niclosamide potentiates TMEM16A and induces vasoconstriction	18
Regulation of NMDAR activation efficiency by environmental factors and subunit composition	18

Why are you talking with snakes? To get new evolutionary insights in cardiac electrophysiology!	18
The funny current If is essential for the fight-or-flight response in cardiac pacemaker cells	18
Connecting the dots on connexin function	17
About hysteresis in Shaker: Response to note by Villalba-Galea	17
Nerve-dependent distribution of subsynaptic type 1 inositol 1,4,5-trisphosphate receptor at the neuromuscular junction	17
Myosin-binding protein-H: Not just filler	16
Orai1 as a potential “fits-all approach” therapeutic target for the treatment of DMD	16
Blood flow-bearing physical forces, endothelial glycocalyx, and liver enzyme mobilization: A hypothesis	16
Mechanism of hydrophobic gating in the acetylcholine receptor channel pore	16
Mechanistic understanding of KCNQ1 activating polyunsaturated fatty acid analogs	15
Mitochondrial morphology governs ATP production rate	15
A complete set of rate constants for a transporter’s catalytic cycle	15
Piezo2 interacts with E-cadherin in specialized gastrointestinal epithelial mechanoreceptors	15
EAAT5 glutamate transporter rapidly binds glutamate with micromolar affinity in mouse rods	15
Examination of conformational dynamics of AdiC transporter with fluorescence-polarization microscopy	15
Null method to estimate the maximal PA at subsaturating concentrations of agonist	14
Blockade of TRPV channels by intracellular spermine	13
BK channels of five different subunit combinations underlie the de novo KCNMA1 G375R channelopathy	13
Molecular mechanism of claudin-15 strand flexibility: A computational study	13
Expression of ENaC subunits in epithelia	13
Worms find PEZO-1’s function easy to swallow	12
Probing function in ligand-gated ion channels without measuring ion transport	12
Acid-sensing ion channel 1a activates IKCa/SKCa channels and contributes to endothelium-dependent dilation	12
GRIN2B disease-associated mutations disrupt the function of BK channels and NMDA receptor signaling nanodomains	12
How a tyrosine primes the pump	12
Allosteric modulation of GluN1/GluN3 NMDA receptors by GluN1-selective competitive antagonists	12
Cooling intact and demembranated trabeculae from rat heart releases myosin motors from their inhibited conformation	12
A novel method for determining murine skeletal muscle fiber type using autofluorescence lifetimes	12
Na+/Ca2+ exchange in enamel cells is dominated by the K+-dependent NCKX exchanger	12
Myosin’s powerstroke transitions define atomic scale movement of cardiac thin filament tropomyosin	12
Variability in reported midpoints of (in)activation of cardiac INa	11
Sodium channel subpopulations with distinct biophysical properties and subcellular localization enhance cardiac conduction	11
Multiscale molecular dynamics simulations predict arachidonic acid binding sites in human ASIC1a and ASIC3 transmembrane domains	11
Asymmetric contribution of a selectivity filter gate in triggering inactivation of CaV1.3 channels	11
Trouble in store for muscle fibers	11
Blue flash sheds light on the roles of individual phosphoserines in CFTR channel activation	11
A high-throughput electrophysiology assay to study the response of PIEZO1 to mechanical stimulation	11
Myosin-binding protein H-like nonsense variants exhibit impaired sarcomere incorporation and alter contractility	11
A sodium channel mutant removes fast inactivation with the inactivation particle bound	11
Dependence of myosin filament structure on intracellular calcium concentration in skeletal muscle	11
Heart failure in mice induces a dysfunction of the sinus node associated with reduced CaMKII signaling	10
Mechanisms of dihydropyridine agonists and antagonists in view of cryo-EM structures of calcium and sodium channels	10
Evaluating sequential and allosteric activation models in IKs channels with mutated voltage sensors	10
Mechanisms underlying dilated cardiomyopathy associated with FKBP12 deficiency	10
Fusion pore flux controls the rise-times of quantal synaptic responses	10
Screening for bilayer-active and likely cytotoxic molecules reveals bilayer-mediated regulation of cell function	10
Directing two-way traffic in the kidney: A tale of two ions	10
Differential regulation of cardiac sodium channels by intracellular fibroblast growth factors	10
The S1 helix is a VIP in VSP	10
Burmese pythons exhibit a transient adaptation to nutrient overload that prevents liver damage	10

Fifty years of gating currents and channel gating	10
Probenecid affects muscle Ca2+ homeostasis and contraction independently from pannexin channel block	10
Phosphorylation of RyR2 simultaneously expands the dyad and rearranges the tetramers	10
Lower troponin expression in the right ventricle of rats explains interventricular differences in E–C coupling	10
Mechanistic insights on KATP channel regulation from cryo-EM structures	9
Mind the midpoints: Rethinking variability in cardiac INa	9
Glycerol storage increases passive stiffness of muscle fibers through effects on titin extensibility	9
Physical activity impacts resting skeletal muscle myosin conformation and lowers its ATP consumption	9
The Cranefield Awards 2022	9
The physical basis of osmosis	9
Examining the calcium sensitivity of skeletal muscle thick filaments	9
Neuronal KCNQ2/3 channels are recruited to lipid raft microdomains by palmitoylation of BACE1	9
Nociceptor sodium channels shape subthreshold phase, upstroke, and shoulder of action potentials	9
Regulation of voltage-sensing structures of CaV1.2 calcium channel by the auxiliary β3-subunit	9
Structural basis for severe pain caused by mutations in the voltage sensors of sodium channel NaV1.7	8
How the Blind Watchmaker messed around with potassium channels	8
Cardiomyocyte ryanodine receptor clusters expand and coalesce after application of isoproterenol	8
Dantrolene inhibition of ryanodine channels (RyR2) in artificial lipid bilayers depends on FKBP12.6	8
TMEM120A/TACAN inhibits mechanically activated PIEZO2 channels	8
Binding motif for RIC-3 chaperon protein in serotonin type 3A receptors	8
Phosphoinositide regulation of voltage-gated sodium channels	8
Dual regulation of Kv7.2/7.3 channels by long-chain n-alcohols	8
A reconstituted depolarization-induced Ca2+ release platform for validation of skeletal muscle disease mutations and drug discovery	8
ON and OFF starburst amacrine cells are controlled by distinct cholinergic pathways	8
Cytosolic Ca2+-dependent Ca2+ release activity primarily determines the ER Ca2+ level in cells expressing the CPVT-linked mutant RYR2	8
The action of Con-ikot-ikot toxin on single AMPA-type glutamate receptors	8
2022	8
A realistic look at rod synapses	8
Thin filament regulation of cardiac muscle power output: Implications for targets to improve human failing hearts	8
Rad protein: An essential player in L-type Ca2+ channel localization and modulation in cardiomyocytes	8