OOIR: Observatory of International Research

Papers

(The TQCC of Journal of General Physiology is 7. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-11-01 to 2024-11-01.)

Article	Citations
Pseudoreplication in physiology: More means less	53
Structural basis of the super- and hyper-relaxed states of myosin II	51
Cannabidiol inhibits the skeletal muscle Nav1.4 by blocking its pore and by altering membrane elasticity	47
Tubulin acetylation increases cytoskeletal stiffness to regulate mechanotransduction in striated muscle	39
Intercalated disk nanoscale structure regulates cardiac conduction	36
ENaC and ROMK channels in the connecting tubule regulate renal K+ secretion	35
The N terminus of myosin-binding protein C extends toward actin filaments in intact cardiac muscle	31
Complexity in genetic cardiomyopathies and new approaches for mechanism-based precision medicine	31
Multiscale modeling of twitch contractions in cardiac trabeculae	31
Evidence that toxin resistance in poison birds and frogs is not rooted in sodium channel mutations and may rely on “toxin sponge” proteins	30
Identification of PUFA interaction sites on the cardiac potassium channel KCNQ1	30
Making waves: A proposed new role for myosin-binding protein C in regulating oscillatory contractions in vertebrate striated muscle	30
Cardiac myosin filaments are directly regulated by calcium	29
Mavacamten has a differential impact on force generation in myofibrils from rabbit psoas and human cardiac muscle	29
Structure versus function: Are new conformations of pannexin 1 yet to be resolved?	27
FXYD protein isoforms differentially modulate human Na/K pump function	26
Physics of mechanotransduction by Piezo ion channels	25
Norfluoxetine inhibits TREK-2 K2P channels by multiple mechanisms including state-independent effects on the selectivity filter gate	24
Dependence of thick filament structure in relaxed mammalian skeletal muscle on temperature and interfilament spacing	23
Cardiomyopathic troponin mutations predominantly occur at its interface with actin and tropomyosin	23
Phenanthrene impacts zebrafish cardiomyocyte excitability by inhibiting IKr and shortening action potential duration	23
Piezo1 regulates cholesterol biosynthesis to influence neural stem cell fate during brain development	22
FXYD proteins and sodium pump regulatory mechanisms	21
Muscle ankyrin repeat protein 1 (MARP1) locks titin to the sarcomeric thin filament and is a passive force regulator	21
Loss of crossbridge inhibition drives pathological cardiac hypertrophy in patients harboring the TPM1 E192K mutation	21

Phosphatidylinositol 4,5-bisphosphate is regenerated by speeding of the PI 4-kinase pathway during long PLC activation	20
Computational study of non-conductive selectivity filter conformations and C-type inactivation in a voltage-dependent potassium channel	19
The distinct role of the four voltage sensors of the skeletal CaV1.1 channel in voltage-dependent activation	19
Zinc binding alters the conformational dynamics and drives the transport cycle of the cation diffusion facilitator YiiP	19
Application of fluorescent dextrans to the brain surface under constant pressure reveals AQP4-independent solute uptake	18
The speed of the hair cell mechanotransducer channel revealed by fluctuation analysis	18
Molecular underpinning of intracellular pH regulation on TMEM16F	18
Piezo1–Pannexin1 complex couples force detection to ATP secretion in cholangiocytes	18
Protein functional dynamics from the rigorous global analysis of DEER data: Conditions, components, and conformations	18
HIFs: New arginine mimic inhibitors of the Hv1 channel with improved VSD–ligand interactions	17
Biological noise is a key determinant of the reproducibility and adaptability of cardiac pacemaking and EC coupling	17
Novel insights into sarcomere regulatory systems control of cardiac thin filament activation	16
Mechanistic insights on KATP channel regulation from cryo-EM structures	16
Mechanical dysfunction of the sarcomere induced by a pathogenic mutation in troponin T drives cellular adaptation	16
Dynein regulates Kv7.4 channel trafficking from the cell membrane	15
The role of molecular diffusion within dendritic spines in synaptic function	15
The versatile regulation of K2P channels by polyanionic lipids of the phosphoinositide and fatty acid metabolism	15
Molecular mechanism of claudin-15 strand flexibility: A computational study	15
Dendritic spine morphology regulates calcium-dependent synaptic weight change	14
Resting and stimulated mouse rod photoreceptors show distinct patterns of vesicle release at ribbon synapses	14
Cardiomyopathic mutations in essential light chain reveal mechanisms regulating the super relaxed state of myosin	14
Myosin-binding protein C stabilizes, but is not the sole determinant of SRX myosin in cardiac muscle	14
Structural basis of cytoplasmic NaV1.5 and NaV1.4 regulation	14
ML277 regulates KCNQ1 single-channel amplitudes and kinetics, modified by voltage sensor state	14
C. elegans PEZO-1 is a mechanosensitive ion channel involved in food sensation	14
Cardiac MyBP-C phosphorylation regulates the Frank–Starling relationship in murine hearts	14
Relaxed tarantula skeletal muscle has two ATP energy-saving mechanisms	13
Synchrony of sarcomeric movement regulates left ventricular pump function in the in vivo beating mouse heart	13
Filament evanescence of myosin II and smooth muscle function	13
The N2A region of titin has a unique structural configuration	13
Multiscale modeling shows that dielectric differences make NaV channels faster than KV channels	12
Large transient capacitive currents in wild-type lysosomal Cl−/H+ antiporter ClC-7 and residual transport activity in the proton glutamate mutant E312A	12
Suppression of ventricular arrhythmias by targeting late L-type Ca2+ current	12
The Orai1 inhibitor BTP2 has multiple effects on Ca2+ handling in skeletal muscle	12
In silico simulations reveal that RYR distribution affects the dynamics of calcium release in cardiac myocytes	12
Detection of Ca2+ transients near ryanodine receptors by targeting fluorescent Ca2+ sensors to the triad	12
TMEM120A/TACAN inhibits mechanically activated PIEZO2 channels	12
Specific ATPases drive compartmentalized glycogen utilization in rat skeletal muscle	12
Gating pore currents occur in CaV1.1 domain III mutants associated with HypoPP	12
Mechanism of use-dependent Kv2 channel inhibition by RY785	12
Single-molecule imaging reveals how mavacamten and PKA modulate ATP turnover in skeletal muscle myofibrils	12
Electrophysiological characterization of the hERG R56Q LQTS variant and targeted rescue by the activator RPR260243	11
Postdevelopmental knockout of Orai1 improves muscle pathology in a mouse model of Duchenne muscular dystrophy	11
Loss of the K+ channel Kv2.1 greatly reduces outward dark current and causes ionic dysregulation and degeneration in rod photoreceptors	11
Function of mammalian M-cones depends on the level of CRALBP in Müller cells	11
How does flecainide impact RyR2 channel function?	11
Epilepsy-associated SCN2A (NaV1.2) variants exhibit diverse and complex functional properties	11
The molecular evolution of function in the CFTR chloride channel	11
Biophysical physiology of phosphoinositide rapid dynamics and regulation in living cells	10
PI(4,5)P2 regulates the gating of NaV1.4 channels	10

A novel Hv1 inhibitor reveals a new mechanism of inhibition of a voltage-sensing domain	10
Conformations of voltage-sensing domain III differentially define NaV channel closed- and open-state inactivation	10
A cooperative knock-on mechanism underpins Ca2+-selective cation permeation in TRPV channels	10
Structural determinants of acid-sensing ion channel potentiation by single chain lipids	10
Mechanisms of proton inhibition and sensitization of the cation channel TRPV3	10
Pore-forming transmembrane domains control ion selectivity and selectivity filter conformation in the KirBac1.1 potassium channel	10
Mutations in proteins involved in E-C coupling and SOCE and congenital myopathies	10
The number of Z-repeats and super-repeats in nebulin greatly varies across vertebrates and scales with animal size	9
Cooling intact and demembranated trabeculae from rat heart releases myosin motors from their inhibited conformation	9
A high-throughput fluorescence lifetime-based assay to detect binding of myosin-binding protein C to F-actin	9
Mutations within the selectivity filter reveal that Kv1 channels have distinct propensities to slow inactivate	9
ANO1, CaV1.2, and IP3R form a localized unit of EC-coupling in mouse pulmonary arterial smooth muscle	9
Cooperative binding ensures the obligatory melibiose/Na+ cotransport in MelB	9
cMyBPC phosphorylation modulates the effect of omecamtiv mecarbil on myocardial force generation	9
Interactions between selectivity filter and pore helix control filter gating in the MthK channel	9
Mutation of a conserved glutamine residue does not abolish desensitization of acid-sensing ion channel 1	9
A controversial issue: Can mitochondria modulate cytosolic calcium and contraction of skeletal muscle fibers?	9
Distinct lipid bilayer compositions have general and protein-specific effects on K+ channel function	9
Proteomic and functional mapping of cardiac NaV1.5 channel phosphorylation sites	9
Neuronal KCNQ2/3 channels are recruited to lipid raft microdomains by palmitoylation of BACE1	9
Remodeled connexin 43 hemichannels alter cardiac excitability and promote arrhythmias	9
An arginine residue in the outer segment of hASIC1a TM1 affects both proton affinity and channel desensitization	8
Lack of evidence for participation of TMEM150C in sensory mechanotransduction	8
Cytosolic Ca2+-dependent Ca2+ release activity primarily determines the ER Ca2+ level in cells expressing the CPVT-linked mutant RYR2	8
Role of a conserved ion-binding site tyrosine in ion selectivity of the Na+/K+ pump	8
Thermal modulation of epicardial Ca2+ dynamics uncovers molecular mechanisms of Ca2+ alternans	8
Characterizing the lipid fingerprint of the mechanosensitive channel Piezo2	8
Different arrhythmia-associated calmodulin mutations have distinct effects on cardiac SK channel regulation	8
Mechanosensitive membrane proteins: Usual and unusual suspects in mediating mechanotransduction	8
cMyBP-C ablation in human engineered cardiac tissue causes progressive Ca2+-handling abnormalities	8
Impact of regulatory light chain mutation K104E on the ATPase and motor properties of cardiac myosin	8
EVAP: A two-photon imaging tool to study conformational changes in endogenous Kv2 channels in live tissues	8
The M1 and pre-M1 segments contribute differently to ion selectivity in ASICs and ENaCs	7
Myosin loop-4 is critical for optimal tropomyosin repositioning on actin during muscle activation and relaxation	7
Caldesmon ablation in mice causes umbilical herniation and alters contractility of fetal urinary bladder smooth muscle	7
Nav1.3 and FGF14 are primary determinants of the TTX-sensitive sodium current in mouse adrenal chromaffin cells	7
Disorder in Ca2+ release unit locations confers robustness but cuts flexibility of heart pacemaking	7
The epithelial potassium channel Kir7.1 is stimulated by progesterone	7
Junctophilins 1, 2, and 3 all support voltage-induced Ca2+ release despite considerable divergence	7
CaV1.2 channelopathic mutations evoke diverse pathophysiological mechanisms	7
IP3R1 underlies diastolic ANO1 activation and pressure-dependent chronotropy in lymphatic collecting vessels	7
Constitutive assembly of Ca2+ entry units in soleus muscle from calsequestrin knockout mice	7
Mechanosensitive channel MscS is critical for termination of the bacterial hypoosmotic permeability response	7
Real-time observation of functional specialization among phosphorylation sites in CFTR	7
Analysis methods and quality criteria for investigating muscle physiology using x-ray diffraction	7
Cm28, a scorpion toxin having a unique primary structure, inhibits KV1.2 and KV1.3 with high affinity	7
Excitation–contraction coupling in cardiac, skeletal, and smooth muscle	7
A method for imaging single molecules at the plasma membrane of live cells within tissue slices	7
Variants of the myosin interacting-heads motif	7
Q-cubed mutant cues clues to CLC antiport mechanism	7