Journal of General Physiology

Article	Citations
Pseudoreplication in physiology: More means less	53
Structural basis of the super- and hyper-relaxed states of myosin II	51
Cannabidiol inhibits the skeletal muscle Nav1.4 by blocking its pore and by altering membrane elasticity	47
Tubulin acetylation increases cytoskeletal stiffness to regulate mechanotransduction in striated muscle	39
Intercalated disk nanoscale structure regulates cardiac conduction	36
ENaC and ROMK channels in the connecting tubule regulate renal K+ secretion	35
The N terminus of myosin-binding protein C extends toward actin filaments in intact cardiac muscle	31
Complexity in genetic cardiomyopathies and new approaches for mechanism-based precision medicine	31
Multiscale modeling of twitch contractions in cardiac trabeculae	31
Evidence that toxin resistance in poison birds and frogs is not rooted in sodium channel mutations and may rely on “toxin sponge” proteins	30
Identification of PUFA interaction sites on the cardiac potassium channel KCNQ1	30
Making waves: A proposed new role for myosin-binding protein C in regulating oscillatory contractions in vertebrate striated muscle	30
Cardiac myosin filaments are directly regulated by calcium	29
Mavacamten has a differential impact on force generation in myofibrils from rabbit psoas and human cardiac muscle	29
Structure versus function: Are new conformations of pannexin 1 yet to be resolved?	27
FXYD protein isoforms differentially modulate human Na/K pump function	26
Physics of mechanotransduction by Piezo ion channels	25
Norfluoxetine inhibits TREK-2 K2P channels by multiple mechanisms including state-independent effects on the selectivity filter gate	24
Cardiomyopathic troponin mutations predominantly occur at its interface with actin and tropomyosin	23
Phenanthrene impacts zebrafish cardiomyocyte excitability by inhibiting IKr and shortening action potential duration	23
Dependence of thick filament structure in relaxed mammalian skeletal muscle on temperature and interfilament spacing	23
Piezo1 regulates cholesterol biosynthesis to influence neural stem cell fate during brain development	22
Muscle ankyrin repeat protein 1 (MARP1) locks titin to the sarcomeric thin filament and is a passive force regulator	21
Loss of crossbridge inhibition drives pathological cardiac hypertrophy in patients harboring the TPM1 E192K mutation	21
FXYD proteins and sodium pump regulatory mechanisms	21

Phosphatidylinositol 4,5-bisphosphate is regenerated by speeding of the PI 4-kinase pathway during long PLC activation	20
The distinct role of the four voltage sensors of the skeletal CaV1.1 channel in voltage-dependent activation	19
Zinc binding alters the conformational dynamics and drives the transport cycle of the cation diffusion facilitator YiiP	19
Computational study of non-conductive selectivity filter conformations and C-type inactivation in a voltage-dependent potassium channel	19
Application of fluorescent dextrans to the brain surface under constant pressure reveals AQP4-independent solute uptake	18
The speed of the hair cell mechanotransducer channel revealed by fluctuation analysis	18
Molecular underpinning of intracellular pH regulation on TMEM16F	18
Piezo1–Pannexin1 complex couples force detection to ATP secretion in cholangiocytes	18
Protein functional dynamics from the rigorous global analysis of DEER data: Conditions, components, and conformations	18
HIFs: New arginine mimic inhibitors of the Hv1 channel with improved VSD–ligand interactions	17
Biological noise is a key determinant of the reproducibility and adaptability of cardiac pacemaking and EC coupling	17
Novel insights into sarcomere regulatory systems control of cardiac thin filament activation	16
Mechanistic insights on KATP channel regulation from cryo-EM structures	16
Mechanical dysfunction of the sarcomere induced by a pathogenic mutation in troponin T drives cellular adaptation	16
Dynein regulates Kv7.4 channel trafficking from the cell membrane	15
The role of molecular diffusion within dendritic spines in synaptic function	15
The versatile regulation of K2P channels by polyanionic lipids of the phosphoinositide and fatty acid metabolism	15
Molecular mechanism of claudin-15 strand flexibility: A computational study	15
Resting and stimulated mouse rod photoreceptors show distinct patterns of vesicle release at ribbon synapses	14
Cardiomyopathic mutations in essential light chain reveal mechanisms regulating the super relaxed state of myosin	14
Myosin-binding protein C stabilizes, but is not the sole determinant of SRX myosin in cardiac muscle	14
Structural basis of cytoplasmic NaV1.5 and NaV1.4 regulation	14
ML277 regulates KCNQ1 single-channel amplitudes and kinetics, modified by voltage sensor state	14
C. elegans PEZO-1 is a mechanosensitive ion channel involved in food sensation	14
Cardiac MyBP-C phosphorylation regulates the Frank–Starling relationship in murine hearts	14
Dendritic spine morphology regulates calcium-dependent synaptic weight change	14
Synchrony of sarcomeric movement regulates left ventricular pump function in the in vivo beating mouse heart	13
Filament evanescence of myosin II and smooth muscle function	13
The N2A region of titin has a unique structural configuration	13
Relaxed tarantula skeletal muscle has two ATP energy-saving mechanisms	13
Suppression of ventricular arrhythmias by targeting late L-type Ca2+ current	12
The Orai1 inhibitor BTP2 has multiple effects on Ca2+ handling in skeletal muscle	12
In silico simulations reveal that RYR distribution affects the dynamics of calcium release in cardiac myocytes	12
Detection of Ca2+ transients near ryanodine receptors by targeting fluorescent Ca2+ sensors to the triad	12
TMEM120A/TACAN inhibits mechanically activated PIEZO2 channels	12
Specific ATPases drive compartmentalized glycogen utilization in rat skeletal muscle	12
Gating pore currents occur in CaV1.1 domain III mutants associated with HypoPP	12
Mechanism of use-dependent Kv2 channel inhibition by RY785	12
Single-molecule imaging reveals how mavacamten and PKA modulate ATP turnover in skeletal muscle myofibrils	12
Multiscale modeling shows that dielectric differences make NaV channels faster than KV channels	12
Large transient capacitive currents in wild-type lysosomal Cl−/H+ antiporter ClC-7 and residual transport activity in the proton glutamate mutant E312A	12
Electrophysiological characterization of the hERG R56Q LQTS variant and targeted rescue by the activator RPR260243	11
Postdevelopmental knockout of Orai1 improves muscle pathology in a mouse model of Duchenne muscular dystrophy	11
Loss of the K+ channel Kv2.1 greatly reduces outward dark current and causes ionic dysregulation and degeneration in rod photoreceptors	11
Function of mammalian M-cones depends on the level of CRALBP in Müller cells	11
How does flecainide impact RyR2 channel function?	11
Epilepsy-associated SCN2A (NaV1.2) variants exhibit diverse and complex functional properties	11
The molecular evolution of function in the CFTR chloride channel	11
PI(4,5)P2 regulates the gating of NaV1.4 channels	10
A novel Hv1 inhibitor reveals a new mechanism of inhibition of a voltage-sensing domain	10

Conformations of voltage-sensing domain III differentially define NaV channel closed- and open-state inactivation	10
A cooperative knock-on mechanism underpins Ca2+-selective cation permeation in TRPV channels	10
Structural determinants of acid-sensing ion channel potentiation by single chain lipids	10
Mechanisms of proton inhibition and sensitization of the cation channel TRPV3	10
Pore-forming transmembrane domains control ion selectivity and selectivity filter conformation in the KirBac1.1 potassium channel	10
Mutations in proteins involved in E-C coupling and SOCE and congenital myopathies	10
Biophysical physiology of phosphoinositide rapid dynamics and regulation in living cells	10
The number of Z-repeats and super-repeats in nebulin greatly varies across vertebrates and scales with animal size	9
Cooling intact and demembranated trabeculae from rat heart releases myosin motors from their inhibited conformation	9
Mutations within the selectivity filter reveal that Kv1 channels have distinct propensities to slow inactivate	9
Interactions between selectivity filter and pore helix control filter gating in the MthK channel	9
Mutation of a conserved glutamine residue does not abolish desensitization of acid-sensing ion channel 1	9
Cooperative binding ensures the obligatory melibiose/Na+ cotransport in MelB	9
cMyBPC phosphorylation modulates the effect of omecamtiv mecarbil on myocardial force generation	9
Neuronal KCNQ2/3 channels are recruited to lipid raft microdomains by palmitoylation of BACE1	9
Remodeled connexin 43 hemichannels alter cardiac excitability and promote arrhythmias	9
A controversial issue: Can mitochondria modulate cytosolic calcium and contraction of skeletal muscle fibers?	9
Distinct lipid bilayer compositions have general and protein-specific effects on K+ channel function	9
Proteomic and functional mapping of cardiac NaV1.5 channel phosphorylation sites	9
A high-throughput fluorescence lifetime-based assay to detect binding of myosin-binding protein C to F-actin	9
ANO1, CaV1.2, and IP3R form a localized unit of EC-coupling in mouse pulmonary arterial smooth muscle	9
An arginine residue in the outer segment of hASIC1a TM1 affects both proton affinity and channel desensitization	8
Lack of evidence for participation of TMEM150C in sensory mechanotransduction	8
Cytosolic Ca2+-dependent Ca2+ release activity primarily determines the ER Ca2+ level in cells expressing the CPVT-linked mutant RYR2	8
Role of a conserved ion-binding site tyrosine in ion selectivity of the Na+/K+ pump	8
Thermal modulation of epicardial Ca2+ dynamics uncovers molecular mechanisms of Ca2+ alternans	8
Characterizing the lipid fingerprint of the mechanosensitive channel Piezo2	8
Different arrhythmia-associated calmodulin mutations have distinct effects on cardiac SK channel regulation	8
Mechanosensitive membrane proteins: Usual and unusual suspects in mediating mechanotransduction	8
cMyBP-C ablation in human engineered cardiac tissue causes progressive Ca2+-handling abnormalities	8
Impact of regulatory light chain mutation K104E on the ATPase and motor properties of cardiac myosin	8
EVAP: A two-photon imaging tool to study conformational changes in endogenous Kv2 channels in live tissues	8
The M1 and pre-M1 segments contribute differently to ion selectivity in ASICs and ENaCs	7
Myosin loop-4 is critical for optimal tropomyosin repositioning on actin during muscle activation and relaxation	7
Caldesmon ablation in mice causes umbilical herniation and alters contractility of fetal urinary bladder smooth muscle	7
Nav1.3 and FGF14 are primary determinants of the TTX-sensitive sodium current in mouse adrenal chromaffin cells	7
Disorder in Ca2+ release unit locations confers robustness but cuts flexibility of heart pacemaking	7
The epithelial potassium channel Kir7.1 is stimulated by progesterone	7
Junctophilins 1, 2, and 3 all support voltage-induced Ca2+ release despite considerable divergence	7
CaV1.2 channelopathic mutations evoke diverse pathophysiological mechanisms	7
IP3R1 underlies diastolic ANO1 activation and pressure-dependent chronotropy in lymphatic collecting vessels	7
Constitutive assembly of Ca2+ entry units in soleus muscle from calsequestrin knockout mice	7
Mechanosensitive channel MscS is critical for termination of the bacterial hypoosmotic permeability response	7
Real-time observation of functional specialization among phosphorylation sites in CFTR	7
Analysis methods and quality criteria for investigating muscle physiology using x-ray diffraction	7
Cm28, a scorpion toxin having a unique primary structure, inhibits KV1.2 and KV1.3 with high affinity	7
Excitation–contraction coupling in cardiac, skeletal, and smooth muscle	7
A method for imaging single molecules at the plasma membrane of live cells within tissue slices	7
Variants of the myosin interacting-heads motif	7
Q-cubed mutant cues clues to CLC antiport mechanism	7
Conformational changes linked to ADP release from human cardiac myosin bound to actin-tropomyosin	6
A dual-clock-driven model of lymphatic muscle cell pacemaking to emulate knock-out of Ano1 or IP3R	6
Similar voltage-sensor movement in spHCN channels can cause closing, opening, or inactivation	6
Pannexin-1 and CaV1.1 show reciprocal interaction during excitation–contraction and excitation–transcription coupling in skeletal muscle	6
The action of Con-ikot-ikot toxin on single AMPA-type glutamate receptors	6
Fast inactivation of Nav current in rat adrenal chromaffin cells involves two independent inactivation pathways	6
Huntingtin regulates calcium fluxes in skeletal muscle	6
A mouse model of Huntington’s disease shows altered ultrastructure of transverse tubules in skeletal muscle fibers	6
Recordings from neuron–HEK cell cocultures reveal the determinants of miniature excitatory postsynaptic currents	6
Myosin motors that cannot bind actin leave their folded OFF state on activation of skeletal muscle	6
Voltage-induced Ca2+ release is supported by junctophilins 1, 2 and 3, and not by junctophilin 4	6
cMyBP-C phosphorylation modulates the time-dependent slowing of unloaded shortening in murine skinned myocardium	6
Mitochondrial morphology governs ATP production rate	6
Phosphate has dual roles in cross-bridge kinetics in rabbit psoas single myofibrils	6
The archaeal glutamate transporter homologue GltPh shows heterogeneous substrate binding	5
Interpretation of presynaptic phenotypes of synaptic plasticity in terms of a two-step priming process	5
Mechanistic understanding of KCNQ1 activating polyunsaturated fatty acid analogs	5
Gating and modulation of an inward-rectifier potassium channel	5
Physical activity impacts resting skeletal muscle myosin conformation and lowers its ATP consumption	5
Superfast excitation–contraction coupling in adult zebrafish skeletal muscle fibers	5
X-ray irradiation triggers immune response in human T-lymphocytes via store-operated Ca2+ entry and NFAT activation	5
Heart failure in mice induces a dysfunction of the sinus node associated with reduced CaMKII signaling	5
Gap junctions and connexin hemichannels both contribute to the electrical properties of retinal pigment epithelium	5
DEG/ENaC/ASIC channels vary in their sensitivity to anti-hypertensive and non-steroidal anti-inflammatory drugs	5
Kir4.1/Kir5.1 channels possess strong intrinsic inward rectification determined by a voltage-dependent K+-flux gating mechanism	5
Expression of ENaC subunits in epithelia	5
Charge-voltage curves of Shaker potassium channel are not hysteretic at steady state	5
Shaker-IR K+ channel gating in heavy water: Role of structural water molecules in inactivation	5
Sarcomere length affects Ca2+ sensitivity of contraction in ischemic but not non-ischemic myocardium	5
Myosin expression and contractile function are altered by replating stem cell–derived cardiomyocytes	5

Dependence of myosin filament structure on intracellular calcium concentration in skeletal muscle	5
CaMKII inhibition reduces arrhythmogenic Ca2+ events in subendocardial cryoinjured rat living myocardial slices	5
Gating and anion selectivity are reciprocally regulated in TMEM16A (ANO1)	5
Acid-sensing ion channel 1a activates IKCa/SKCa channels and contributes to endothelium-dependent dilation	5
A model for how Gβγ couples Gα to GPCR	5
Burmese pythons exhibit a transient adaptation to nutrient overload that prevents liver damage	5
The zinc-binding motif of TRPM7 acts as an oxidative stress sensor to regulate its channel activity	5
Cooperativity of myosin II motors in the non-regulated and regulated thin filaments investigated with high-speed AFM	5
Transport of metformin metabolites by guanidinium exporters of the small multidrug resistance family	4
When is a hydrophobic gate not a hydrophobic gate?	4
Allosteric modulation of GluN1/GluN3 NMDA receptors by GluN1-selective competitive antagonists	4
ORAI3 is dispensable for store-operated Ca2+ entry and immune responses by lymphocytes and macrophages	4
How do batrachotoxin-bearing frogs and birds avoid self intoxication?	4
Fifty years of gating currents and channel gating	4
The structural and functional integrities of porcine myocardium are mostly preserved by cryopreservation	4
Evidence for S2 flexibility by direct visualization of quantum dot–labeled myosin heads and rods within smooth muscle myosin filaments moving on actin in vitro	4
A mathematical model to quantify RYR Ca2+ leak and associated heat production in resting human skeletal muscle fibers	4
The role of Zn2+ in shaping intracellular Ca2+ dynamics in the heart	4
A Cantú syndrome mutation produces dual effects on KATP channels by disrupting ankyrin B regulation	4
BK channels of five different subunit combinations underlie the de novo KCNMA1 G375R channelopathy	4
Piezo1 is a mechanosensor channel in CNS capillaries	4
Extracellular mechanotransduction	4
Cold and warmth intensify pain-linked sodium channel gating effects and persistent currents	4
PACAP and acetylcholine cause distinct Ca2+ signals and secretory responses in chromaffin cells	4
Contraction–relaxation coupling is unaltered by exercise training and infarction in isolated canine myocardium	4
Deciphering mechanically activated ion channels at the single-channel level in dorsal root ganglion neurons	4
A flexible GAS belt responds to pore mutations changing the ion selectivity of proton-gated channels	4
State-dependent inhibition of BK channels by the opioid agonist loperamide	4
RLC phosphorylation amplifies Ca2+ sensitivity of force in myocardium from cMyBP-C knockout mice	4
Calcium current modulation by the γ1 subunit depends on alternative splicing of CaV1.1	4
Role of ryanodine receptor 2 and FK506-binding protein 12.6 dissociation in pulmonary hypertension	4
Acute exposure to extracellular BTP2 does not inhibit Ca2+ release during EC coupling in intact skeletal muscle fibers	4
Functional and structural differences between skinned and intact muscle preparations	4
Kv12-encoded K+ channels drive the day–night switch in the repetitive firing rates of SCN neurons	3
A high-throughput electrophysiology assay to study the response of PIEZO1 to mechanical stimulation	3
Alkali metal cations modulate the geometry of different binding sites in HCN4 selectivity filter for permeation or block	3
L-type channel inactivation balances the increased peak calcium current due to absence of Rad in cardiomyocytes	3
Segregation of Ca2+ signaling in olfactory signal transduction	3
Mechanism of external K+ sensitivity of KCNQ1 channels	3
Resin-acid derivatives bind to multiple sites on the voltage-sensor domain of the Shaker potassium channel	3
Phosphorylation of RyR2 simultaneously expands the dyad and rearranges the tetramers	3
Calcium binding and permeation in TRPV channels: Insights from molecular dynamics simulations	3
Unraveling the mysteries of the titin–N2A signalosome	3
cAMP-PKA signaling modulates the automaticity of human iPSC-derived cardiomyocytes	3
Is Bauman’s “liquid modernity” influencing the way we are doing science?	3
Catecholamines are key modulators of ventricular repolarization patterns in the ball python (Python regius)	3
Blockade of TRPV channels by intracellular spermine	3
Cannabidiol potentiates hyperpolarization-activated cyclic nucleotide–gated (HCN4) channels	3
Cardiomyocyte sarcomere length variability: Membrane fluorescence versus second harmonic generation myosin imaging	3
Myosin and tropomyosin–troponin complementarily regulate thermal activation of muscles	3
Differential regulation of cardiac sodium channels by intracellular fibroblast growth factors	3
Mechanisms of dihydropyridine agonists and antagonists in view of cryo-EM structures of calcium and sodium channels	3
Machine learning meets Monte Carlo methods for models of muscle’s molecular machinery to classify mutations	3
Microscopic mechanism of PIEZO1 activation by pressure-induced membrane stretch	3
Myosin essential light chain 1sa decelerates actin and thin filament gliding on β-myosin molecules	3
Dantrolene inhibition of ryanodine channels (RyR2) in artificial lipid bilayers depends on FKBP12.6	3
Troponin-I–induced tropomyosin pivoting defines thin-filament function in relaxed and active muscle	3
Hippocampal neurons maintain a large PtdIns(4)P pool that results in faster PtdIns(4,5)P2 synthesis	3
Lower troponin expression in the right ventricle of rats explains interventricular differences in E–C coupling	3
Gating of RYR2 channels from the arrhythmic RYR2-P2328S mouse heart and some unexpected actions of flecainide	3
Determinants of iFGF13-mediated regulation of myocardial voltage-gated sodium (NaV) channels in mouse	3
Titin–N2A: More than a signaling node?	3
Urea transport in human red blood cells: Donor variation compared to chloride, glucose, and water transport	2
Elucidating molecular mechanisms of protoxin-II state-specific binding to the human NaV1.7 channel	2
Cardiomyocyte ryanodine receptor clusters expand and coalesce after application of isoproterenol	2
A reconstituted depolarization-induced Ca2+ release platform for validation of skeletal muscle disease mutations and drug discovery	2
Nebulin: Size matters for optimal muscle function	2
D-type K+ current rules the function of electrically coupled neurons in a species-specific fashion	2
Extracellular histone proteins activate P2XR7 channel current	2
Eccentric contraction-induced strength loss in dystrophin-deficient muscle: Preparations, protocols, and mechanisms	2
Probenecid affects muscle Ca2+ homeostasis and contraction independently from pannexin channel block	2
How can AI accelerate advances in physiology?	2
CaV1.3 L-type Ca2+ channel modulates pancreatic β-cell electrical activity and survival	2
Disease-associated KCNMA1 variants decrease circadian clock robustness in channelopathy mouse models	2
Permeant cations modulate pore dynamics and gating of TRPV1 ion channels	2
Probing function in ligand-gated ion channels without measuring ion transport	2
Urea and water are transported through different pathways in the red blood cell membrane	2
Optimization of CFTR gating through the evolution of its extracellular loops	2
Calcium activation through thick and thin?	2
A strategy for determining the equilibrium constants for heteromeric ion channels in a complex model	2
Understanding Ca2+ alternans	2
Mice with R2509C-RYR1 mutation exhibit dysfunctional Ca2+ dynamics in primary skeletal myocytes	2
Cardiac mechanical efficiency is preserved in primary cardiac hypertrophy despite impaired mechanical function	2
Multiscale molecular dynamics simulations predict arachidonic acid binding sites in human ASIC1a and ASIC3 transmembrane domains	2
Anionic omega currents from single countercharge mutants in the voltage-sensing domain of Ci-VSP	2
The contribution of N-terminal truncated cMyBPC to in vivo cardiac function	2
The taming of a scramblase	2
Piezo1 helps bile on the pressure	2
Targeting late ICaL to close the window to ventricular arrhythmias	2
Ion channel regulation of gut immunity	2
The funny current If is essential for the fight-or-flight response in cardiac pacemaker cells	2
Sarcomere length in the beating heart: Synchronicity is optional	2
Directing two-way traffic in the kidney: A tale of two ions	2
TMEM16A activation for the fast block to polyspermy in the African clawed frog does not require conventional activation of egg PLCs	2
BK channel modulation by positively charged peptides and auxiliary γ subunits mediated by the Ca2+-bowl site	2