Journal of General Physiology

Article	Citations
Spliced isoforms of the cardiac Nav1.5 channel modify channel activation by distinct structural mechanisms	71
Mutations in proteins involved in E-C coupling and SOCE and congenital myopathies	39
Differential state-dependent Nav1.8 inhibition by suzetrigine, LTGO-33, and A-887826	39
Role of ryanodine receptor 2 and FK506-binding protein 12.6 dissociation in pulmonary hypertension	37
Interrogating the gating motions of the NaK channel	37
Anionic omega currents from single countercharge mutants in the voltage-sensing domain of Ci-VSP	35
The epithelial potassium channel Kir7.1 is stimulated by progesterone	32
Implication of CREB in the calcium regulation by ischemia/reperfusion in cardiomyocytes	27
Kv1.1 channels help set the pace	26
Machine learning meets Monte Carlo methods for models of muscle’s molecular machinery to classify mutations	25
Hippocampal neurons maintain a large PtdIns(4)P pool that results in faster PtdIns(4,5)P2 synthesis	23
Stochastic force generation in an isometric binary mechanical system	22
Gating pore currents occur in CaV1.1 domain III mutants associated with HypoPP	22
EVAP: A two-photon imaging tool to study conformational changes in endogenous Kv2 channels in live tissues	21
Light induces a rapid increase in cAMP and activates PKA in rod outer segments of the frog retina	21
Mechanism of external K+ sensitivity of KCNQ1 channels	20
Regulation of NMDAR activation efficiency by environmental factors and subunit composition	20
Variants of the myosin interacting-heads motif	19
Correction: A mathematical model to quantify RYR Ca2+ leak and associated heat production in resting human skeletal muscle fibers	19
Reconstituting depolarization-induced calcium release	18
Niclosamide potentiates TMEM16A and induces vasoconstriction	17
How do batrachotoxin-bearing frogs and birds avoid self intoxication?	17
The funny current If is essential for the fight-or-flight response in cardiac pacemaker cells	17
Distinct properties and activation of hexameric and heptameric Pannexin 1 channel concatemers	17
Superfast excitation–contraction coupling in adult zebrafish skeletal muscle fibers	17

Examination of conformational dynamics of AdiC transporter with fluorescence-polarization microscopy	16
ANO1, CaV1.2, and IP3R form a localized unit of EC-coupling in mouse pulmonary arterial smooth muscle	16
Myosin-binding protein-H: Not just filler	16
Why are you talking with snakes? To get new evolutionary insights in cardiac electrophysiology!	16
Pannexin-1 and CaV1.1 show reciprocal interaction during excitation–contraction and excitation–transcription coupling in skeletal muscle	16
Orai1 as a potential “fits-all approach” therapeutic target for the treatment of DMD	16
About hysteresis in Shaker: Response to note by Villalba-Galea	15
Blood flow-bearing physical forces, endothelial glycocalyx, and liver enzyme mobilization: A hypothesis	15
Piezo1 is a mechanosensor channel in CNS capillaries	15
Connecting the dots on connexin function	15
Mitochondrial morphology governs ATP production rate	15
Segregation of Ca2+ signaling in olfactory signal transduction	15
Nerve-dependent distribution of subsynaptic type 1 inositol 1,4,5-trisphosphate receptor at the neuromuscular junction	15
Increased basal metabolic rate in mice susceptible to malignant hyperthermia and heat stroke	15
Piezo2 interacts with E-cadherin in specialized gastrointestinal epithelial mechanoreceptors	14
Mechanism of hydrophobic gating in the acetylcholine receptor channel pore	14
BK channels of five different subunit combinations underlie the de novo KCNMA1 G375R channelopathy	14
Allosteric modulation of GluN1/GluN3 NMDA receptors by GluN1-selective competitive antagonists	14
Molecular mechanism of claudin-15 strand flexibility: A computational study	14
Cooling intact and demembranated trabeculae from rat heart releases myosin motors from their inhibited conformation	14
Na+/Ca2+ exchange in enamel cells is dominated by the K+-dependent NCKX exchanger	14
EAAT5 glutamate transporter rapidly binds glutamate with micromolar affinity in mouse rods	13
A complete set of rate constants for a transporter’s catalytic cycle	13
Probing function in ligand-gated ion channels without measuring ion transport	12
Recordings of action potentials, charge movements, and sarcoplasmic reticulum Ca2+ release in isolated adult zebrafish fast skeletal muscle fibers reveals very fast kinetics of excitation–contraction	12
Null method to estimate the maximal PA at subsaturating concentrations of agonist	12
Myosin’s powerstroke transitions define atomic scale movement of cardiac thin filament tropomyosin	12
Probenecid affects sarcoplasmic reticulum Ca2+ release and depresses contractile activation in mouse skeletal muscle	12
A non-transmembrane channel formed by Ca2+-bound calsequestrin-2	12
Possible mechanisms underlying the dynamic assembly of calcium entry units: The role of temperature and pH	11
Acid-sensing ion channel 1a activates IKCa/SKCa channels and contributes to endothelium-dependent dilation	11
Arrhythmogenesis in heart cells involves reverse E–C coupling and reverse electrotonic conduction along T-tubules	11
Mechanistic understanding of KCNQ1 activating polyunsaturated fatty acid analogs	11
Expression of ENaC subunits in epithelia	11
Blockade of TRPV channels by intracellular spermine	11
A sodium channel mutant removes fast inactivation with the inactivation particle bound	10
Sodium channel subpopulations with distinct biophysical properties and subcellular localization enhance cardiac conduction	10
Worms find PEZO-1’s function easy to swallow	10
Molecular mechanisms responsible for the sexual dimorphism in pancreatic β-cell insulin release	10
Asymmetric contribution of a selectivity filter gate in triggering inactivation of CaV1.3 channels	10
The speed of the hair cell mechanotransducer channel revealed by fluctuation analysis	10
A novel method for determining murine skeletal muscle fiber type using autofluorescence lifetimes	10
Dependence of myosin filament structure on intracellular calcium concentration in skeletal muscle	10
How a tyrosine primes the pump	10
A high-throughput electrophysiology assay to study the response of PIEZO1 to mechanical stimulation	10
Angiotensin 1–7 prevents the excessive force loss resulting from 14- and 28-day denervation in mouse EDL and soleus muscle	9
Screening for bilayer-active and likely cytotoxic molecules reveals bilayer-mediated regulation of cell function	9
Evaluating sequential and allosteric activation models in IKs channels with mutated voltage sensors	9
Fragmentation and roles of junctophilin1 in muscle of patients with cytosolic leak of stored calcium	9
Trouble in store for muscle fibers	9

Heart failure in mice induces a dysfunction of the sinus node associated with reduced CaMKII signaling	9
Phosphorylation of RyR2 simultaneously expands the dyad and rearranges the tetramers	9
Fifty years of gating currents and channel gating	9
Reduced plasticity and microtubule densification in muscular dystrophy-related cardiomyopathy	9
Blue flash sheds light on the roles of individual phosphoserines in CFTR channel activation	9
Intrinsic contractile dysfunction in a surgical model of muscle hypertrophy	9
Probenecid affects muscle Ca2+ homeostasis and contraction independently from pannexin channel block	9
Mechanisms of dihydropyridine agonists and antagonists in view of cryo-EM structures of calcium and sodium channels	9
Multiscale molecular dynamics simulations predict arachidonic acid binding sites in human ASIC1a and ASIC3 transmembrane domains	9
Mechanistic insights on KATP channel regulation from cryo-EM structures	8
Differential regulation of cardiac sodium channels by intracellular fibroblast growth factors	8
Burmese pythons exhibit a transient adaptation to nutrient overload that prevents liver damage	8
Glycerol storage increases passive stiffness of muscle fibers through effects on titin extensibility	8
Fusion pore flux controls the rise-times of quantal synaptic responses	8
The S1 helix is a VIP in VSP	8
GPCR signaling is highly compartmentalized in human cardiomyocytes and severely remodeled in atrial fibrillation	8
Mechanisms underlying dilated cardiomyopathy associated with FKBP12 deficiency	8
Species dependent cardiac electrophysiological effects elicited by various potassium channel blocking drugs	8
Neuronal KCNQ2/3 channels are recruited to lipid raft microdomains by palmitoylation of BACE1	8
The physical basis of osmosis	8
Nociceptor sodium channels shape subthreshold phase, upstroke, and shoulder of action potentials	8
Directing two-way traffic in the kidney: A tale of two ions	8
Lower troponin expression in the right ventricle of rats explains interventricular differences in E–C coupling	8
Voltage sensor movements of CaV1.1 during an action potential in skeletal muscle fibers	8
Acute exposure to the chemotherapy cisplatin has a biphasic effect in cardiac contractility	8
Lifetime of autofluorescence: A novel method to determine murine skeletal muscle fiber types	7
Examining the calcium sensitivity of skeletal muscle thick filaments	7
Insect elementary calcium release events measured in honeybee muscle cells	7
Dual regulation of Kv7.2/7.3 channels by long-chain n-alcohols	7
The Cranefield Awards 2022	7
State-dependent inhibition of BK channels by the opioid agonist loperamide	7
Phosphoinositide regulation of voltage-gated sodium channels	7
Physical activity impacts resting skeletal muscle myosin conformation and lowers its ATP consumption	7
The action of Con-ikot-ikot toxin on single AMPA-type glutamate receptors	7
Structural basis for severe pain caused by mutations in the voltage sensors of sodium channel NaV1.7	7
How the Blind Watchmaker messed around with potassium channels	7
Evidence that toxin resistance in poison birds and frogs is not rooted in sodium channel mutations and may rely on “toxin sponge” proteins	6
TMEM120A/TACAN inhibits mechanically activated PIEZO2 channels	6
Rad protein: An essential player in L-type Ca2+ channel localization and modulation in cardiomyocytes	6
Different species, different gap junctions?	6
Binding motif for RIC-3 chaperon protein in serotonin type 3A receptors	6
Thin filament regulation of cardiac muscle power output: Implications for targets to improve human failing hearts	6
Cytosolic Ca2+-dependent Ca2+ release activity primarily determines the ER Ca2+ level in cells expressing the CPVT-linked mutant RYR2	6
2022	6
Sniffing out Ca2+ signaling in olfactory cilia	6
Carboxyl-group compounds activate voltage-gated potassium channels via a distinct mechanism	6
Dantrolene inhibition of ryanodine channels (RyR2) in artificial lipid bilayers depends on FKBP12.6	6
ON and OFF starburst amacrine cells are controlled by distinct cholinergic pathways	6
Cardiomyocyte ryanodine receptor clusters expand and coalesce after application of isoproterenol	6
Essential role of Orai1 and SARAF in vascular remodeling	6
How could simulations elucidate Nav1.5 channel blockers mechanism?	6
A reconstituted depolarization-induced Ca2+ release platform for validation of skeletal muscle disease mutations and drug discovery	6
A realistic look at rod synapses	6
Myosin binding protein-C modulates loaded sarcomere shortening in rodent permeabilized cardiac myocytes	5
Microscopic mechanism of PIEZO1 activation by pressure-induced membrane stretch	5
Mechanisms of a novel regulatory light chain–dependent cardiac myosin inhibitor	5
Spatially resolving how cMyBP-C phosphorylation and haploinsufficiency in porcine and human myofibrils affect β-cardiac myosin activity	5
Biophysical characteristics of TRIC-A and TRIC-B channels and their regulation of RYR2	5
Stable oxidative posttranslational modifications alter the gating properties of RyR1	5
Correction: Charge-voltage curves of Shaker potassium channel are not hysteretic at steady state	5
ERG responses to high-frequency flickers require FAT3 signaling in mouse retinal bipolar cells	5
Disease-associated KCNMA1 variants decrease circadian clock robustness in channelopathy mouse models	5
RyR2 phosphorylation alters dyad architecture	5
ω-Grammotoxin-SIA inhibits voltage-gated Na+ channel currents	5
Cooperativity of myosin II motors in the non-regulated and regulated thin filaments investigated with high-speed AFM	5
Molecular-level evidence of force maintenance by smooth muscle myosin during LC20 dephosphorylation	5
Time-dependent effect of FKBP12 loss in the development of dilated cardiomyopathy	5
Deciphering mechanically activated ion channels at the single-channel level in dorsal root ganglion neurons	5
The distinct role of the four voltage sensors of the skeletal CaV1.1 channel in voltage-dependent activation	5
Suppression of ventricular arrhythmias by targeting late L-type Ca2+ current	5
Localized cardiomyocyte lipid accumulation is associated with slowed epicardial conduction in rats	5
Cardiac myosin filaments are directly regulated by calcium	5
Kv12-encoded K+ channels drive the day–night switch in the repetitive firing rates of SCN neurons	5
Super relaxed myosins loosen up to different cues in cardiac and skeletal muscle sarcomeres	5
Myosin expression and contractile function are altered by replating stem cell–derived cardiomyocytes	5
Calcium has a direct effect on thick filament activation in porcine myocardium	4
Catecholamines help snakes have a change of heart	4
Electro-metabolic signaling	4
Protein functional dynamics from the rigorous global analysis of DEER data: Conditions, components, and conformations	4
The road to the brain in Timothy syndrome is paved with enhanced CaV1.2 activation gating	4

Sarcomere length affects Ca2+ sensitivity of contraction in ischemic but not non-ischemic myocardium	4
Structural determinants of acid-sensing ion channel potentiation by single chain lipids	4
RLC phosphorylation amplifies Ca2+ sensitivity of force in myocardium from cMyBP-C knockout mice	4
Correction: Segregation of Ca2+ signaling in olfactory signal transduction	4
Therapeutic effects of novel type 1 ryanodine receptor inhibitor on malignant hyperthermia	4
Obscurin deficiency leads to compensated dilated cardiomyopathy and increased arrhythmias	4
Calcium binding and permeation in TRPV channels: Insights from molecular dynamics simulations	4
Disruption of a side portal pathway permits closed-state inactivation by BK β subunit N termini	4
Disorder in Ca2+ release unit locations confers robustness but cuts flexibility of heart pacemaking	4
Ion channel regulation of gut immunity	4
Exercise training may reduce fragmented mitochondria in the ischemic-reperfused heart through DRP1	4
Tirasemtiv enhances submaximal muscle tension in an Acta1:p.Asp286Gly mouse model of nemaline myopathy	4
Understanding the role of mutations in voltage-gated sodium ion channels for cardiovascular disorders	4
Artificial intelligence approaches to the volumetric quantification of glycogen granules in EM images of human tissue	4
Calcium current modulation by the γ1 subunit depends on alternative splicing of CaV1.1	4
Mutant D96V calmodulin induces unexpected remodeling of cardiac nanostructure and physiology	4
X rays activate T cell calcium signaling	4
Sensory neuron sodium channels as pain targets; from cocaine to Journavx (VX-548, suzetrigine)	3
Distinct roles for CaV1.1’s voltage-sensing domains	3
The differential impacts of equivalent gating-charge mutations in voltage-gated sodium channels	3
Correction: A controversial issue: Can mitochondria modulate cytosolic calcium and contraction of skeletal muscle fibers?	3
Modeling the effects of thin filament near-neighbor cooperative interactions in mammalian myocardium	3
Hydrophobic residues in S1 modulate enzymatic function and voltage sensing in voltage-sensing phosphatase	3
Light drives the developmental progression of outer retinal function	3
Honeybee CaV4 has distinct permeation, inactivation, and pharmacology from homologous NaV channels	3
Mechanism of acid-sensing ion channel modulation by Hi1a	3
Single-molecule imaging reveals how mavacamten and PKA modulate ATP turnover in skeletal muscle myofibrils	3
SMR transporters meet the challenge of metformin metabolites	3
Gating and modulation of an inward-rectifier potassium channel	3
On the link between antibiotic resistance, diabetes, and wastewater	3
JGP in 2024	3
IP3R1 underlies diastolic ANO1 activation and pressure-dependent chronotropy in lymphatic collecting vessels	3
Ion channels of cold transduction and transmission	2
The spatial distribution of glycogen and glycogen consumption in muscle cells	2
BK channel modulation by positively charged peptides and auxiliary γ subunits mediated by the Ca2+-bowl site	2
Troponin I phosphorylation is essential for cardiac reserve	2
Catecholamines are key modulators of ventricular repolarization patterns in the ball python (Python regius)	2
Effect of a sensing charge mutation on the deactivation of KV7.2 channels	2
Alkali metal cations modulate the geometry of different binding sites in HCN4 selectivity filter for permeation or block	2
Correction: Urea and water are transported through different pathways in the red blood cell membrane	2
Structural and functional insights into α-actinin isoforms and their implications in cardiovascular disease	2
Piezo1–Pannexin1 complex couples force detection to ATP secretion in cholangiocytes	2
A scorpion toxin takes the sting out of T cell activation	2
Structural basis of the super- and hyper-relaxed states of myosin II	2
The structural and functional integrities of porcine myocardium are mostly preserved by cryopreservation	2
Ctenophores and parahoxozoans independently evolved functionally diverse voltage-gated K+ channels	2
Remodeled connexin 43 hemichannels alter cardiac excitability and promote arrhythmias	2
Septin-7 is indispensable in skeletal muscle regeneration	2
Is haploinsufficiency a sufficient mechanism for MYBPC3 truncating mutations?	2
RYR1-related myopathies: Expanding the spectrum of morphological presentation	2
The biophysical properties of TRIC-A and TRIC-B and their interactions with RyR2	2
Excitation–contraction coupling in cardiac, skeletal, and smooth muscle	2
Closed-state inactivation of cardiac, skeletal, and neuronal sodium channels is isoform specific	2
Cardiac muscle disease and therapeutic targets	2
Modeling the mechanism of Ca2+ release in skeletal muscle by DHPRs easing inhibition at RyR I1-sites	2
Kv1 channel inactivation: Slow and slower	2
Myosin and tropomyosin–troponin complementarily regulate thermal activation of muscles	2
PACAP and acetylcholine cause distinct Ca2+ signals and secretory responses in chromaffin cells	2
Discovery of new intracellular junctions: The calcium entry units (CEUs)	2
Correction: The architecture of invaginating rod synapses slows glutamate diffusion and shapes synaptic responses	2
Activation of excitatory glycine NMDA receptors: At the mercy of a whimsical GluN1 subunit	2
Mechanosensitive membrane proteins: Usual and unusual suspects in mediating mechanotransduction	2
Structural basis for diamide modulation of ryanodine receptor	2
Preconditioning contractions prevent Ca2+-dependent proteolysis of STAC3 and prolonged force depression after eccentric contractions	2
JGP in 2025	2
Permeant cations modulate pore dynamics and gating of TRPV1 ion channels	2
Characterizing the lipid fingerprint of the mechanosensitive channel Piezo2	2
Cryo-EM reveals local and global structural rearrangements in RYR mutants	2