Journal of General Physiology

Article	Citations
Anionic omega currents from single countercharge mutants in the voltage-sensing domain of Ci-VSP	79
NALCN/Cch1 channelosome subunits originated in early eukaryotes	45
Investigating the role of the I–II linker in Nav1.5 channel function	45
Interrogating the gating motions of the NaK channel	41
Kv1.1 channels help set the pace	38
Spliced isoforms of the cardiac Nav1.5 channel modify channel activation by distinct structural mechanisms	37
Machine learning meets Monte Carlo methods for models of muscle’s molecular machinery to classify mutations	32
Differential state-dependent Nav1.8 inhibition by suzetrigine, LTGO-33, and A-887826	24
Correction: A mathematical model to quantify RYR Ca2+ leak and associated heat production in resting human skeletal muscle fibers	23
Voltage-sensor gating charge interactions bimodally regulate voltage dependence and kinetics of calcium channel activation	23
Mutations in proteins involved in E-C coupling and SOCE and congenital myopathies	23
Role of ryanodine receptor 2 and FK506-binding protein 12.6 dissociation in pulmonary hypertension	23
Reconstituting depolarization-induced calcium release	22
Variants of the myosin interacting-heads motif	22
Stochastic force generation in an isometric binary mechanical system	22
ANO1, CaV1.2, and IP3R form a localized unit of EC-coupling in mouse pulmonary arterial smooth muscle	21
Altered NaV1.9 channel activity in two Tyr66Ser variant carriers with small fiber dysfunction	21
Mechanism of external K+ sensitivity of KCNQ1 channels	20
Light induces a rapid increase in cAMP and activates PKA in rod outer segments of the frog retina	20
Distinct properties and activation of hexameric and heptameric Pannexin 1 channel concatemers	20
Hippocampal neurons maintain a large PtdIns(4)P pool that results in faster PtdIns(4,5)P2 synthesis	19
Superfast excitation–contraction coupling in adult zebrafish skeletal muscle fibers	19
Why are you talking with snakes? To get new evolutionary insights in cardiac electrophysiology!	18
The funny current If is essential for the fight-or-flight response in cardiac pacemaker cells	18
Segregation of Ca2+ signaling in olfactory signal transduction	18

Niclosamide potentiates TMEM16A and induces vasoconstriction	18
Regulation of NMDAR activation efficiency by environmental factors and subunit composition	18
Nerve-dependent distribution of subsynaptic type 1 inositol 1,4,5-trisphosphate receptor at the neuromuscular junction	17
Connecting the dots on connexin function	17
About hysteresis in Shaker: Response to note by Villalba-Galea	17
Mechanism of hydrophobic gating in the acetylcholine receptor channel pore	16
Myosin-binding protein-H: Not just filler	16
Orai1 as a potential “fits-all approach” therapeutic target for the treatment of DMD	16
Blood flow-bearing physical forces, endothelial glycocalyx, and liver enzyme mobilization: A hypothesis	16
EAAT5 glutamate transporter rapidly binds glutamate with micromolar affinity in mouse rods	15
Examination of conformational dynamics of AdiC transporter with fluorescence-polarization microscopy	15
Mechanistic understanding of KCNQ1 activating polyunsaturated fatty acid analogs	15
Mitochondrial morphology governs ATP production rate	15
A complete set of rate constants for a transporter’s catalytic cycle	15
Piezo2 interacts with E-cadherin in specialized gastrointestinal epithelial mechanoreceptors	15
Null method to estimate the maximal PA at subsaturating concentrations of agonist	14
Molecular mechanism of claudin-15 strand flexibility: A computational study	13
Expression of ENaC subunits in epithelia	13
Blockade of TRPV channels by intracellular spermine	13
BK channels of five different subunit combinations underlie the de novo KCNMA1 G375R channelopathy	13
Na+/Ca2+ exchange in enamel cells is dominated by the K+-dependent NCKX exchanger	12
Myosin’s powerstroke transitions define atomic scale movement of cardiac thin filament tropomyosin	12
Worms find PEZO-1’s function easy to swallow	12
Probing function in ligand-gated ion channels without measuring ion transport	12
Acid-sensing ion channel 1a activates IKCa/SKCa channels and contributes to endothelium-dependent dilation	12
GRIN2B disease-associated mutations disrupt the function of BK channels and NMDA receptor signaling nanodomains	12
How a tyrosine primes the pump	12
Allosteric modulation of GluN1/GluN3 NMDA receptors by GluN1-selective competitive antagonists	12
Cooling intact and demembranated trabeculae from rat heart releases myosin motors from their inhibited conformation	12
A novel method for determining murine skeletal muscle fiber type using autofluorescence lifetimes	12
A high-throughput electrophysiology assay to study the response of PIEZO1 to mechanical stimulation	11
Myosin-binding protein H-like nonsense variants exhibit impaired sarcomere incorporation and alter contractility	11
A sodium channel mutant removes fast inactivation with the inactivation particle bound	11
Dependence of myosin filament structure on intracellular calcium concentration in skeletal muscle	11
Variability in reported midpoints of (in)activation of cardiac INa	11
Sodium channel subpopulations with distinct biophysical properties and subcellular localization enhance cardiac conduction	11
Multiscale molecular dynamics simulations predict arachidonic acid binding sites in human ASIC1a and ASIC3 transmembrane domains	11
Asymmetric contribution of a selectivity filter gate in triggering inactivation of CaV1.3 channels	11
Trouble in store for muscle fibers	11
Blue flash sheds light on the roles of individual phosphoserines in CFTR channel activation	11
Fifty years of gating currents and channel gating	10
Probenecid affects muscle Ca2+ homeostasis and contraction independently from pannexin channel block	10
Phosphorylation of RyR2 simultaneously expands the dyad and rearranges the tetramers	10
Lower troponin expression in the right ventricle of rats explains interventricular differences in E–C coupling	10
Heart failure in mice induces a dysfunction of the sinus node associated with reduced CaMKII signaling	10
Mechanisms of dihydropyridine agonists and antagonists in view of cryo-EM structures of calcium and sodium channels	10
Evaluating sequential and allosteric activation models in IKs channels with mutated voltage sensors	10
Mechanisms underlying dilated cardiomyopathy associated with FKBP12 deficiency	10
Fusion pore flux controls the rise-times of quantal synaptic responses	10
Screening for bilayer-active and likely cytotoxic molecules reveals bilayer-mediated regulation of cell function	10

Directing two-way traffic in the kidney: A tale of two ions	10
Differential regulation of cardiac sodium channels by intracellular fibroblast growth factors	10
The S1 helix is a VIP in VSP	10
Burmese pythons exhibit a transient adaptation to nutrient overload that prevents liver damage	10
Examining the calcium sensitivity of skeletal muscle thick filaments	9
Nociceptor sodium channels shape subthreshold phase, upstroke, and shoulder of action potentials	9
Neuronal KCNQ2/3 channels are recruited to lipid raft microdomains by palmitoylation of BACE1	9
Regulation of voltage-sensing structures of CaV1.2 calcium channel by the auxiliary β3-subunit	9
Mechanistic insights on KATP channel regulation from cryo-EM structures	9
Mind the midpoints: Rethinking variability in cardiac INa	9
Glycerol storage increases passive stiffness of muscle fibers through effects on titin extensibility	9
Physical activity impacts resting skeletal muscle myosin conformation and lowers its ATP consumption	9
The Cranefield Awards 2022	9
The physical basis of osmosis	9
Structural basis for severe pain caused by mutations in the voltage sensors of sodium channel NaV1.7	8
How the Blind Watchmaker messed around with potassium channels	8
Cardiomyocyte ryanodine receptor clusters expand and coalesce after application of isoproterenol	8
Dantrolene inhibition of ryanodine channels (RyR2) in artificial lipid bilayers depends on FKBP12.6	8
TMEM120A/TACAN inhibits mechanically activated PIEZO2 channels	8
Binding motif for RIC-3 chaperon protein in serotonin type 3A receptors	8
Phosphoinositide regulation of voltage-gated sodium channels	8
Dual regulation of Kv7.2/7.3 channels by long-chain n-alcohols	8
A reconstituted depolarization-induced Ca2+ release platform for validation of skeletal muscle disease mutations and drug discovery	8
ON and OFF starburst amacrine cells are controlled by distinct cholinergic pathways	8
Cytosolic Ca2+-dependent Ca2+ release activity primarily determines the ER Ca2+ level in cells expressing the CPVT-linked mutant RYR2	8
The action of Con-ikot-ikot toxin on single AMPA-type glutamate receptors	8
2022	8
A realistic look at rod synapses	8
Thin filament regulation of cardiac muscle power output: Implications for targets to improve human failing hearts	8
Rad protein: An essential player in L-type Ca2+ channel localization and modulation in cardiomyocytes	8
Different species, different gap junctions?	7
Carboxyl-group compounds activate voltage-gated potassium channels via a distinct mechanism	7
RyR2 phosphorylation alters dyad architecture	7
Sniffing out Ca2+ signaling in olfactory cilia	7
ERG responses to high-frequency flickers require FAT3 signaling in mouse retinal bipolar cells	7
How could simulations elucidate Nav1.5 channel blockers mechanism?	7
ω-Grammotoxin-SIA inhibits voltage-gated Na+ channel currents	7
Sarcomere length affects Ca2+ sensitivity of contraction in ischemic but not non-ischemic myocardium	6
Calcium binding and permeation in TRPV channels: Insights from molecular dynamics simulations	6
Disruption of a side portal pathway permits closed-state inactivation by BK β subunit N termini	6
Myosin expression and contractile function are altered by replating stem cell–derived cardiomyocytes	6
Microscopic mechanism of PIEZO1 activation by pressure-induced membrane stretch	6
Deciphering mechanically activated ion channels at the single-channel level in dorsal root ganglion neurons	6
Correction: Charge-voltage curves of Shaker potassium channel are not hysteretic at steady state	6
Spatially resolving how cMyBP-C phosphorylation and haploinsufficiency in porcine and human myofibrils affect β-cardiac myosin activity	6
Electro-metabolic signaling	6
Artificial intelligence approaches to the volumetric quantification of glycogen granules in EM images of human tissue	6
The road to the brain in Timothy syndrome is paved with enhanced CaV1.2 activation gating	6
Cooperativity of myosin II motors in the non-regulated and regulated thin filaments investigated with high-speed AFM	6
Super relaxed myosins loosen up to different cues in cardiac and skeletal muscle sarcomeres	6
Cortical spreading depression dynamics are altered by topical D2 receptor ligands	6
Correction: The calcium-binding protein S100A1 binds to titin’s N2A insertion sequence in a pH-dependent manner	6
Mechanisms of a novel regulatory light chain–dependent cardiac myosin inhibitor	6
Localized cardiomyocyte lipid accumulation is associated with slowed epicardial conduction in rats	6
Cardiac myosin filaments are directly regulated by calcium	6
Obscurin deficiency leads to compensated dilated cardiomyopathy and increased arrhythmias	6
GSK3β-driven phosphorylation of ABLIM1 regulates its interactions with titin cardiac muscle	6
Stable oxidative posttranslational modifications alter the gating properties of RyR1	6
Understanding the role of mutations in voltage-gated sodium ion channels for cardiovascular disorders	6
Molecular-level evidence of force maintenance by smooth muscle myosin during LC20 dephosphorylation	6
Time-dependent effect of FKBP12 loss in the development of dilated cardiomyopathy	6
Disease-associated KCNMA1 variants decrease circadian clock robustness in channelopathy mouse models	6
Myosin binding protein-C modulates loaded sarcomere shortening in rodent permeabilized cardiac myocytes	6
Kv12-encoded K+ channels drive the day–night switch in the repetitive firing rates of SCN neurons	6
Tirasemtiv enhances submaximal muscle tension in an Acta1:p.Asp286Gly mouse model of nemaline myopathy	6
Exercise training may reduce fragmented mitochondria in the ischemic-reperfused heart through DRP1	5
Ion channel regulation of gut immunity	5
RLC phosphorylation amplifies Ca2+ sensitivity of force in myocardium from cMyBP-C knockout mice	5
On the link between antibiotic resistance, diabetes, and wastewater	5
Structural determinants of acid-sensing ion channel potentiation by single chain lipids	5
Calcium current modulation by the γ1 subunit depends on alternative splicing of CaV1.1	5
X rays activate T cell calcium signaling	5
The differential impacts of equivalent gating-charge mutations in voltage-gated sodium channels	5
Catecholamines help snakes have a change of heart	5
Calcium has a direct effect on thick filament activation in porcine myocardium	5
Correction: Segregation of Ca2+ signaling in olfactory signal transduction	5
Disorder in Ca2+ release unit locations confers robustness but cuts flexibility of heart pacemaking	5
Light drives the developmental progression of outer retinal function	5
Kinetics of aldosterone-dependent ENaC trafficking in the kidney	4
Correction: A controversial issue: Can mitochondria modulate cytosolic calcium and contraction of skeletal muscle fibers?	4

Gating and modulation of an inward-rectifier potassium channel	4
IP3R1 underlies diastolic ANO1 activation and pressure-dependent chronotropy in lymphatic collecting vessels	4
Correction: Urea and water are transported through different pathways in the red blood cell membrane	4
JGP in 2024	4
Modeling the effects of thin filament near-neighbor cooperative interactions in mammalian myocardium	4
Honeybee CaV4 has distinct permeation, inactivation, and pharmacology from homologous NaV channels	4
Hydrophobic residues in S1 modulate enzymatic function and voltage sensing in voltage-sensing phosphatase	4
Mechanism of acid-sensing ion channel modulation by Hi1a	4
SMR transporters meet the challenge of metformin metabolites	4
Permeant cations modulate pore dynamics and gating of TRPV1 ion channels	4
Single-molecule imaging reveals how mavacamten and PKA modulate ATP turnover in skeletal muscle myofibrils	4
Sensory neuron sodium channels as pain targets; from cocaine to Journavx (VX-548, suzetrigine)	4
Catecholamines are key modulators of ventricular repolarization patterns in the ball python (Python regius)	3
Characterizing the lipid fingerprint of the mechanosensitive channel Piezo2	3
Correction: The architecture of invaginating rod synapses slows glutamate diffusion and shapes synaptic responses	3
Alkali metal cations modulate the geometry of different binding sites in HCN4 selectivity filter for permeation or block	3
BK channel modulation by positively charged peptides and auxiliary γ subunits mediated by the Ca2+-bowl site	3
Modeling the mechanism of Ca2+ release in skeletal muscle by DHPRs easing inhibition at RyR I1-sites	3
Effect of a sensing charge mutation on the deactivation of KV7.2 channels	3
JGP in 2025	3
Activation of excitatory glycine NMDA receptors: At the mercy of a whimsical GluN1 subunit	3
Excitation–contraction coupling in cardiac, skeletal, and smooth muscle	3
Kv1 channel inactivation: Slow and slower	3
Mechanosensitive membrane proteins: Usual and unusual suspects in mediating mechanotransduction	3
PACAP and acetylcholine cause distinct Ca2+ signals and secretory responses in chromaffin cells	3
Structural and functional insights into α-actinin isoforms and their implications in cardiovascular disease	3
Closed-state inactivation of cardiac, skeletal, and neuronal sodium channels is isoform specific	3
Mn quenching in activated zebrafish muscle fibers does not result from store-operated Ca entry	3
A scorpion toxin takes the sting out of T cell activation	3
Is haploinsufficiency a sufficient mechanism for MYBPC3 truncating mutations?	3
The biophysical properties of TRIC-A and TRIC-B and their interactions with RyR2	3
The spatial distribution of glycogen and glycogen consumption in muscle cells	3