Journal of General Physiology

Article	Citations
Disruption of membrane cholesterol organization impairs the activity of PIEZO1 channel clusters	97
Structural basis of the super- and hyper-relaxed states of myosin II	46
Pseudoreplication in physiology: More means less	45
ATP synthase: Evolution, energetics, and membrane interactions	42
Cannabidiol inhibits the skeletal muscle Nav1.4 by blocking its pore and by altering membrane elasticity	38
Intercalated disk nanoscale structure regulates cardiac conduction	32
Tubulin acetylation increases cytoskeletal stiffness to regulate mechanotransduction in striated muscle	30
Pre-assembled Ca2+ entry units and constitutively active Ca2+ entry in skeletal muscle of calsequestrin-1 knockout mice	28
ENaC and ROMK channels in the connecting tubule regulate renal K+ secretion	28
The N terminus of myosin-binding protein C extends toward actin filaments in intact cardiac muscle	28
Making waves: A proposed new role for myosin-binding protein C in regulating oscillatory contractions in vertebrate striated muscle	27
Multiscale modeling of twitch contractions in cardiac trabeculae	26
Complexity in genetic cardiomyopathies and new approaches for mechanism-based precision medicine	25
Evidence that toxin resistance in poison birds and frogs is not rooted in sodium channel mutations and may rely on “toxin sponge” proteins	24
Mavacamten has a differential impact on force generation in myofibrils from rabbit psoas and human cardiac muscle	23
Cardiac myosin filaments are directly regulated by calcium	22
Identification of PUFA interaction sites on the cardiac potassium channel KCNQ1	22
Cardiomyopathic troponin mutations predominantly occur at its interface with actin and tropomyosin	22
Dependence of thick filament structure in relaxed mammalian skeletal muscle on temperature and interfilament spacing	21
Structure versus function: Are new conformations of pannexin 1 yet to be resolved?	21
FXYD protein isoforms differentially modulate human Na/K pump function	21
The very low number of calcium-induced permeability transition pores in the single mitochondrion	21
Spike frequency–dependent inhibition and excitation of neural activity by high-frequency ultrasound	21
Phenanthrene impacts zebrafish cardiomyocyte excitability by inhibiting IKr and shortening action potential duration	20
Physics of mechanotransduction by Piezo ion channels	19

Phosphatidylinositol 4,5-bisphosphate is regenerated by speeding of the PI 4-kinase pathway during long PLC activation	19
Norfluoxetine inhibits TREK-2 K2P channels by multiple mechanisms including state-independent effects on the selectivity filter gate	18
Differentially poised vesicles underlie fast and slow components of release at single synapses	17
Muscle ankyrin repeat protein 1 (MARP1) locks titin to the sarcomeric thin filament and is a passive force regulator	17
Piezo1 regulates cholesterol biosynthesis to influence neural stem cell fate during brain development	16
The distinct role of the four voltage sensors of the skeletal CaV1.1 channel in voltage-dependent activation	16
FXYD proteins and sodium pump regulatory mechanisms	16
Piezo1–Pannexin1 complex couples force detection to ATP secretion in cholangiocytes	15
Molecular underpinning of intracellular pH regulation on TMEM16F	15
Novel insights into sarcomere regulatory systems control of cardiac thin filament activation	15
Single-cell temperature mapping with fluorescent thermometer nanosheets	15
The role of molecular diffusion within dendritic spines in synaptic function	15
Differential regulation of BK channels by fragile X mental retardation protein	15
Computational study of non-conductive selectivity filter conformations and C-type inactivation in a voltage-dependent potassium channel	14
Biological noise is a key determinant of the reproducibility and adaptability of cardiac pacemaking and EC coupling	14
The speed of the hair cell mechanotransducer channel revealed by fluctuation analysis	14
Structural basis of cytoplasmic NaV1.5 and NaV1.4 regulation	14
Mechanism and potential sites of potassium interaction with glutamate transporters	14
Mechanical dysfunction of the sarcomere induced by a pathogenic mutation in troponin T drives cellular adaptation	13
Relaxed tarantula skeletal muscle has two ATP energy-saving mechanisms	13
HIFs: New arginine mimic inhibitors of the Hv1 channel with improved VSD–ligand interactions	13
Application of fluorescent dextrans to the brain surface under constant pressure reveals AQP4-independent solute uptake	13
Cardiac MyBP-C phosphorylation regulates the Frank–Starling relationship in murine hearts	13
The N2A region of titin has a unique structural configuration	13
Loss of crossbridge inhibition drives pathological cardiac hypertrophy in patients harboring the TPM1 E192K mutation	13
Zinc binding alters the conformational dynamics and drives the transport cycle of the cation diffusion facilitator YiiP	13
Combining endocannabinoids with retigabine for enhanced M-channel effect and improved KV7 subtype selectivity	13
Prostaglandin E2 stimulates the epithelial sodium channel (ENaC) in cultured mouse cortical collecting duct cells in an autocrine manner	13
Resting and stimulated mouse rod photoreceptors show distinct patterns of vesicle release at ribbon synapses	13
Dynein regulates Kv7.4 channel trafficking from the cell membrane	13
Cardiomyopathic mutations in essential light chain reveal mechanisms regulating the super relaxed state of myosin	13
Mechanism of calcium potentiation of the α7 nicotinic acetylcholine receptor	12
The Orai1 inhibitor BTP2 has multiple effects on Ca2+ handling in skeletal muscle	12
Filament evanescence of myosin II and smooth muscle function	12
Detection of Ca2+ transients near ryanodine receptors by targeting fluorescent Ca2+ sensors to the triad	11
Mechanistic insights on KATP channel regulation from cryo-EM structures	11
In silico simulations reveal that RYR distribution affects the dynamics of calcium release in cardiac myocytes	11
Multiscale modeling shows that dielectric differences make NaV channels faster than KV channels	11
Depressed neuromuscular transmission causes weakness in mice lacking BK potassium channels	11
Protein functional dynamics from the rigorous global analysis of DEER data: Conditions, components, and conformations	11
Lower Ca2+ enhances the K+-induced force depression in normal and HyperKPP mouse muscles	11
Gating pore currents occur in CaV1.1 domain III mutants associated with HypoPP	11
Large transient capacitive currents in wild-type lysosomal Cl−/H+ antiporter ClC-7 and residual transport activity in the proton glutamate mutant E312A	11
Specific ATPases drive compartmentalized glycogen utilization in rat skeletal muscle	10
ML277 regulates KCNQ1 single-channel amplitudes and kinetics, modified by voltage sensor state	10
Molecular mechanism of claudin-15 strand flexibility: A computational study	10
Structural determinants of acid-sensing ion channel potentiation by single chain lipids	10
Mechanism of use-dependent Kv2 channel inhibition by RY785	10
C. elegans PEZO-1 is a mechanosensitive ion channel involved in food sensation	10
Loss of the K+ channel Kv2.1 greatly reduces outward dark current and causes ionic dysregulation and degeneration in rod photoreceptors	10

How does flecainide impact RyR2 channel function?	10
Polyamine blockade and binding energetics in the MthK potassium channel	9
Proteomic and functional mapping of cardiac NaV1.5 channel phosphorylation sites	9
The molecular evolution of function in the CFTR chloride channel	9
Synchrony of sarcomeric movement regulates left ventricular pump function in the in vivo beating mouse heart	9
Function of mammalian M-cones depends on the level of CRALBP in Müller cells	9
Myosin-binding protein C stabilizes, but is not the sole determinant of SRX myosin in cardiac muscle	9
A high-throughput fluorescence lifetime-based assay to detect binding of myosin-binding protein C to F-actin	9
Dendritic spine morphology regulates calcium-dependent synaptic weight change	9
Suppression of ventricular arrhythmias by targeting late L-type Ca2+ current	9
E1784K, the most common Brugada syndrome and long-QT syndrome type 3 mutant, disrupts sodium channel inactivation through two separate mechanisms	9
The versatile regulation of K2P channels by polyanionic lipids of the phosphoinositide and fatty acid metabolism	9
Cooperative binding ensures the obligatory melibiose/Na+ cotransport in MelB	8
Rational design of a mutation to investigate the role of the brain protein TRIP8b in limiting the cAMP response of HCN channels in neurons	8
Postdevelopmental knockout of Orai1 improves muscle pathology in a mouse model of Duchenne muscular dystrophy	8
Engineered high-affinity zinc binding site reveals gating configurations of a human proton channel	8
Neuronal KCNQ2/3 channels are recruited to lipid raft microdomains by palmitoylation of BACE1	8
Electrophysiological characterization of the hERG R56Q LQTS variant and targeted rescue by the activator RPR260243	8
Mechanisms of proton inhibition and sensitization of the cation channel TRPV3	8
Single-molecule imaging reveals how mavacamten and PKA modulate ATP turnover in skeletal muscle myofibrils	8
Impact of regulatory light chain mutation K104E on the ATPase and motor properties of cardiac myosin	8
An arginine residue in the outer segment of hASIC1a TM1 affects both proton affinity and channel desensitization	8
A novel voltage-clamp/dye uptake assay reveals saturable transport of molecules through CALHM1 and connexin channels	8
cMyBPC phosphorylation modulates the effect of omecamtiv mecarbil on myocardial force generation	8
Pore-forming transmembrane domains control ion selectivity and selectivity filter conformation in the KirBac1.1 potassium channel	8
A novel Hv1 inhibitor reveals a new mechanism of inhibition of a voltage-sensing domain	7
Q-cubed mutant cues clues to CLC antiport mechanism	7
Role of a conserved ion-binding site tyrosine in ion selectivity of the Na+/K+ pump	7
Thermal modulation of epicardial Ca2+ dynamics uncovers molecular mechanisms of Ca2+ alternans	7
Caldesmon ablation in mice causes umbilical herniation and alters contractility of fetal urinary bladder smooth muscle	7
How hot are single cells?	7
Variants of the myosin interacting-heads motif	7
Constitutive activity of dopamine receptor type 1 (D1R) increases CaV2.2 currents in PFC neurons	7
Cm28, a scorpion toxin having a unique primary structure, inhibits KV1.2 and KV1.3 with high affinity	7
The number of Z-repeats and super-repeats in nebulin greatly varies across vertebrates and scales with animal size	7
Distinct lipid bilayer compositions have general and protein-specific effects on K+ channel function	7
Disorder in Ca2+ release unit locations confers robustness but cuts flexibility of heart pacemaking	7
The activation gate controls steady-state inactivation and recovery from inactivation in Shaker	7
A controversial issue: Can mitochondria modulate cytosolic calcium and contraction of skeletal muscle fibers?	7
Cooling intact and demembranated trabeculae from rat heart releases myosin motors from their inhibited conformation	7
Mechanosensitive membrane proteins: Usual and unusual suspects in mediating mechanotransduction	6
Excitation–contraction coupling in cardiac, skeletal, and smooth muscle	6
A cooperative knock-on mechanism underpins Ca2+-selective cation permeation in TRPV channels	6
Determinants of Ca2+ release restitution: Insights from genetically altered animals and mathematical modeling	6
Pannexin-1 and CaV1.1 show reciprocal interaction during excitation–contraction and excitation–transcription coupling in skeletal muscle	6
EVAP: A two-photon imaging tool to study conformational changes in endogenous Kv2 channels in live tissues	6
The M1 and pre-M1 segments contribute differently to ion selectivity in ASICs and ENaCs	6
Analysis methods and quality criteria for investigating muscle physiology using x-ray diffraction	6
CaV1.2 channelopathic mutations evoke diverse pathophysiological mechanisms	6
Different arrhythmia-associated calmodulin mutations have distinct effects on cardiac SK channel regulation	6
TMEM120A/TACAN inhibits mechanically activated PIEZO2 channels	6
A method for imaging single molecules at the plasma membrane of live cells within tissue slices	6
Mutation of a conserved glutamine residue does not abolish desensitization of acid-sensing ion channel 1	6
Cell-wide mapping of Orai1 channel activity reveals functional heterogeneity in STIM1-Orai1 puncta	6
cMyBP-C phosphorylation modulates the time-dependent slowing of unloaded shortening in murine skinned myocardium	6
Conformations of voltage-sensing domain III differentially define NaV channel closed- and open-state inactivation	6
Epilepsy-associated SCN2A (NaV1.2) variants exhibit diverse and complex functional properties	6
Cytosolic Ca2+-dependent Ca2+ release activity primarily determines the ER Ca2+ level in cells expressing the CPVT-linked mutant RYR2	6
Nav1.3 and FGF14 are primary determinants of the TTX-sensitive sodium current in mouse adrenal chromaffin cells	6
The epithelial potassium channel Kir7.1 is stimulated by progesterone	6
Shaker-IR K+ channel gating in heavy water: Role of structural water molecules in inactivation	5
Slc7a5 alters Kvβ-mediated regulation of Kv1.2	5
Chemical regulation of Kv7 channels: Diverse scaffolds, sites, and mechanisms of action	5
Myosin loop-4 is critical for optimal tropomyosin repositioning on actin during muscle activation and relaxation	5
Kir4.1/Kir5.1 channels possess strong intrinsic inward rectification determined by a voltage-dependent K+-flux gating mechanism	5
The action of Con-ikot-ikot toxin on single AMPA-type glutamate receptors	5
ANO1, CaV1.2, and IP3R form a localized unit of EC-coupling in mouse pulmonary arterial smooth muscle	5
Sarcomere length affects Ca2+ sensitivity of contraction in ischemic but not non-ischemic myocardium	5
Junctophilins 1, 2, and 3 all support voltage-induced Ca2+ release despite considerable divergence	5
cMyBP-C ablation in human engineered cardiac tissue causes progressive Ca2+-handling abnormalities	5
The archaeal glutamate transporter homologue GltPh shows heterogeneous substrate binding	5
A mouse model of Huntington’s disease shows altered ultrastructure of transverse tubules in skeletal muscle fibers	5
Constitutive assembly of Ca2+ entry units in soleus muscle from calsequestrin knockout mice	5
Fast inactivation of Nav current in rat adrenal chromaffin cells involves two independent inactivation pathways	5
Zn2+-induced changes in Cav2.3 channel function: An electrophysiological and modeling study	5
Biophysical physiology of phosphoinositide rapid dynamics and regulation in living cells	5
CaMKII inhibition reduces arrhythmogenic Ca2+ events in subendocardial cryoinjured rat living myocardial slices	5
DEG/ENaC/ASIC channels vary in their sensitivity to anti-hypertensive and non-steroidal anti-inflammatory drugs	5
Recordings from neuron–HEK cell cocultures reveal the determinants of miniature excitatory postsynaptic currents	5
Mechanosensitive channel MscS is critical for termination of the bacterial hypoosmotic permeability response	5

Myosin motors that cannot bind actin leave their folded OFF state on activation of skeletal muscle	4
A model for how Gβγ couples Gα to GPCR	4
Lack of evidence for participation of TMEM150C in sensory mechanotransduction	4
Pathways for nicotinic receptor desensitization	4
Gap junctions and connexin hemichannels both contribute to the electrical properties of retinal pigment epithelium	4
How do batrachotoxin-bearing frogs and birds avoid self intoxication?	4
The zinc-binding motif of TRPM7 acts as an oxidative stress sensor to regulate its channel activity	4
Evidence for S2 flexibility by direct visualization of quantum dot–labeled myosin heads and rods within smooth muscle myosin filaments moving on actin in vitro	4
IP3R1 underlies diastolic ANO1 activation and pressure-dependent chronotropy in lymphatic collecting vessels	4
ORAI3 is dispensable for store-operated Ca2+ entry and immune responses by lymphocytes and macrophages	4
Piezo1 is a mechanosensor channel in CNS capillaries	4
Voltage-induced Ca2+ release is supported by junctophilins 1, 2 and 3, and not by junctophilin 4	4
Charge-voltage curves of Shaker potassium channel are not hysteretic at steady state	4
Characterizing the lipid fingerprint of the mechanosensitive channel Piezo2	4
Burmese pythons exhibit a transient adaptation to nutrient overload that prevents liver damage	4
A flexible GAS belt responds to pore mutations changing the ion selectivity of proton-gated channels	4
Calcium current modulation by the γ1 subunit depends on alternative splicing of CaV1.1	4
Remodeled connexin 43 hemichannels alter cardiac excitability and promote arrhythmias	4
Acid-sensing ion channel 1a activates IKCa/SKCa channels and contributes to endothelium-dependent dilation	4
Mutations within the selectivity filter reveal that Kv1 channels have distinct propensities to slow inactivate	4
Phosphate has dual roles in cross-bridge kinetics in rabbit psoas single myofibrils	4
Heart failure in mice induces a dysfunction of the sinus node associated with reduced CaMKII signaling	4
Superfast excitation–contraction coupling in adult zebrafish skeletal muscle fibers	4
PI(4,5)P2 regulates the gating of NaV1.4 channels	4
Extracellular mechanotransduction	4
Acute exposure to extracellular BTP2 does not inhibit Ca2+ release during EC coupling in intact skeletal muscle fibers	4
Real-time observation of functional specialization among phosphorylation sites in CFTR	4
The action of a BK channel opener	4
Titin–N2A: More than a signaling node?	3
X-ray irradiation triggers immune response in human T-lymphocytes via store-operated Ca2+ entry and NFAT activation	3
cAMP-PKA signaling modulates the automaticity of human iPSC-derived cardiomyocytes	3
Cooperativity of myosin II motors in the non-regulated and regulated thin filaments investigated with high-speed AFM	3
A dual-clock-driven model of lymphatic muscle cell pacemaking to emulate knock-out of Ano1 or IP3R	3
Gating and anion selectivity are reciprocally regulated in TMEM16A (ANO1)	3
Gating and modulation of an inward-rectifier potassium channel	3
Myosin and tropomyosin–troponin complementarily regulate thermal activation of muscles	3
Lower troponin expression in the right ventricle of rats explains interventricular differences in E–C coupling	3
Gating of RYR2 channels from the arrhythmic RYR2-P2328S mouse heart and some unexpected actions of flecainide	3
Unraveling the mysteries of the titin–N2A signalosome	3
Functional and structural differences between skinned and intact muscle preparations	3
Similar voltage-sensor movement in spHCN channels can cause closing, opening, or inactivation	3
Contraction–relaxation coupling is unaltered by exercise training and infarction in isolated canine myocardium	3
BK channels of five different subunit combinations underlie the de novo KCNMA1 G375R channelopathy	3
Segregation of Ca2+ signaling in olfactory signal transduction	3
Interactions between selectivity filter and pore helix control filter gating in the MthK channel	3
The N-terminal domain in TRPM2 channel is a conserved nucleotide binding site	3
Mutations in proteins involved in E-C coupling and SOCE and congenital myopathies	3
PACAP and acetylcholine cause distinct Ca2+ signals and secretory responses in chromaffin cells	3
Myosin expression and contractile function are altered by replating stem cell–derived cardiomyocytes	3
A mathematical model to quantify RYR Ca2+ leak and associated heat production in resting human skeletal muscle fibers	3
Transport of metformin metabolites by guanidinium exporters of the small multidrug resistance family	3
Expression of ENaC subunits in epithelia	3
State-dependent inhibition of BK channels by the opioid agonist loperamide	3
Conformational changes linked to ADP release from human cardiac myosin bound to actin-tropomyosin	3
ECC meets CEU—New focus on the backdoor for calcium ions in skeletal muscle cells	3
Understanding Ca2+ alternans	2
Microscopic mechanism of PIEZO1 activation by pressure-induced membrane stretch	2
Fifty years of gating currents and channel gating	2
A high-throughput electrophysiology assay to study the response of PIEZO1 to mechanical stimulation	2
How can AI accelerate advances in physiology?	2
Catecholamines are key modulators of ventricular repolarization patterns in the ball python (Python regius)	2
The taming of a scramblase	2
A reconstituted depolarization-induced Ca2+ release platform for validation of skeletal muscle disease mutations and drug discovery	2
Probing function in ligand-gated ion channels without measuring ion transport	2
Nebulin: Size matters for optimal muscle function	2
FMRP differentially regulates BK channels	2
Mechanism of external K+ sensitivity of KCNQ1 channels	2
Roles for the SNAP25 linker domain in the fusion pore and a dynamic plasma membrane SNARE “acceptor” complex	2
Urea transport in human red blood cells: Donor variation compared to chloride, glucose, and water transport	2
Cadmium activates AMPA and NMDA receptors with M3 helix cysteine substitutions	2
Myosin essential light chain 1sa decelerates actin and thin filament gliding on β-myosin molecules	2
Cold and warmth intensify pain-linked sodium channel gating effects and persistent currents	2
Dependence of myosin filament structure on intracellular calcium concentration in skeletal muscle	2
Cardiac mechanical efficiency is preserved in primary cardiac hypertrophy despite impaired mechanical function	2
Cardiomyocyte ryanodine receptor clusters expand and coalesce after application of isoproterenol	2
Piezo1 helps bile on the pressure	2
Allosteric modulation of GluN1/GluN3 NMDA receptors by GluN1-selective competitive antagonists	2
Mitochondrial morphology governs ATP production rate	2
Physical activity impacts resting skeletal muscle myosin conformation and lowers its ATP consumption	2
Optimization of CFTR gating through the evolution of its extracellular loops	2
Cardiomyocyte sarcomere length variability: Membrane fluorescence versus second harmonic generation myosin imaging	2
A strategy for determining the equilibrium constants for heteromeric ion channels in a complex model	2
Kv12-encoded K+ channels drive the day–night switch in the repetitive firing rates of SCN neurons	2
BK channel modulation by positively charged peptides and auxiliary γ subunits mediated by the Ca2+-bowl site	2
Deciphering mechanically activated ion channels at the single-channel level in dorsal root ganglion neurons	2
Role of ryanodine receptor 2 and FK506-binding protein 12.6 dissociation in pulmonary hypertension	2
Is Bauman’s “liquid modernity” influencing the way we are doing science?	2
CaV1.3 L-type Ca2+ channel modulates pancreatic β-cell electrical activity and survival	2
Zn2+ to probe voltage-gated proton (Hv1) channels	2
L-type channel inactivation balances the increased peak calcium current due to absence of Rad in cardiomyocytes	2
Troponin-I–induced tropomyosin pivoting defines thin-filament function in relaxed and active muscle	2
Targeting late ICaL to close the window to ventricular arrhythmias	2
Urea and water are transported through different pathways in the red blood cell membrane	2
Resin-acid derivatives bind to multiple sites on the voltage-sensor domain of the Shaker potassium channel	2
Sarcomere length in the beating heart: Synchronicity is optional	2