Journal of Experimental Medicine

(The TQCC of Journal of Experimental Medicine is 26. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-02-01 to 2024-02-01.)
Targeting potential drivers of COVID-19: Neutrophil extracellular traps1080
SARS-CoV-2–triggered neutrophil extracellular traps mediate COVID-19 pathology607
Neuroinvasion of SARS-CoV-2 in human and mouse brain572
Inflammasomes are activated in response to SARS-CoV-2 infection and are associated with COVID-19 severity in patients519
Transforming growth factor–β in tissue fibrosis458
Measuring SARS-CoV-2 neutralizing antibody activity using pseudotyped and chimeric viruses456
The many faces of the anti-COVID immune response407
The blood–brain barrier in health and disease: Important unanswered questions345
Mouse model of SARS-CoV-2 reveals inflammatory role of type I interferon signaling314
Lipid metabolism and cancer297
Ferroptosis in infection, inflammation, and immunity272
Neutrophil extracellular traps infiltrate the lung airway, interstitial, and vascular compartments in severe COVID-19259
Antibody potency, effector function, and combinations in protection and therapy for SARS-CoV-2 infection in vivo247
Highly functional virus-specific cellular immune response in asymptomatic SARS-CoV-2 infection244
Blood plasma phosphorylated-tau isoforms track CNS change in Alzheimer’s disease219
Anti-human TREM2 induces microglia proliferation and reduces pathology in an Alzheimer’s disease model212
Interleukin-17–induced neutrophil extracellular traps mediate resistance to checkpoint blockade in pancreatic cancer203
The role of IL-22 in intestinal health and disease197
Preexisting autoantibodies to type I IFNs underlie critical COVID-19 pneumonia in patients with APS-1166
COVID-19 and emerging viral infections: The case for interferon lambda166
Intratumoral accumulation of gut microbiota facilitates CD47-based immunotherapy via STING signaling159
Phenotypical and functional alteration of unconventional T cells in severe COVID-19 patients137
PD-1 restraint of regulatory T cell suppressive activity is critical for immune tolerance133
Microglia in Alzheimer's disease at single-cell level. Are there common patterns in humans and mice?133
Accumulation of long-chain fatty acids in the tumor microenvironment drives dysfunction in intrapancreatic CD8+ T cells131
Dynamic innate immune response determines susceptibility to SARS-CoV-2 infection and early replication kinetics128
Mutations in COPA lead to abnormal trafficking of STING to the Golgi and interferon signaling126
SHP2 inhibition diminishes KRASG12C cycling and promotes tumor microenvironment remodeling123
Auto-antibodies to type I IFNs can underlie adverse reactions to yellow fever live attenuated vaccine117
Mapping and role of T cell response in SARS-CoV-2–infected mice114
Analysis of classical neutrophils and polymorphonuclear myeloid-derived suppressor cells in cancer patients and tumor-bearing mice113
Single-cell analysis of the cellular heterogeneity and interactions in the injured mouse spinal cord113
Multi-omic profiling reveals widespread dysregulation of innate immunity and hematopoiesis in COVID-19112
Single-cell analysis of germinal-center B cells informs on lymphoma cell of origin and outcome108
Neutrophil phenotypes and functions in cancer: A consensus statement107
Tumor-infiltrating dendritic cell states are conserved across solid human cancers105
A defect in COPI-mediated transport of STING causes immune dysregulation in COPA syndrome103
PKM2 promotes Th17 cell differentiation and autoimmune inflammation by fine-tuning STAT3 activation103
Inflammation as a regulator of hematopoietic stem cell function in disease, aging, and clonal selection100
Type 1 conventional dendritic cells are systemically dysregulated early in pancreatic carcinogenesis99
Forty years with coronaviruses98
Historical overview of the interleukin-6 family cytokine97
Persistent cellular immunity to SARS-CoV-2 infection97
SARS-CoV-2 induces human plasmacytoid predendritic cell diversification via UNC93B and IRAK495
SARS-CoV-2–related MIS-C: A key to the viral and genetic causes of Kawasaki disease?94
β-Catenin induces transcriptional expression of PD-L1 to promote glioblastoma immune evasion93
Glutamine depletion regulates Slug to promote EMT and metastasis in pancreatic cancer93
The mRNA m6A reader YTHDF2 suppresses proinflammatory pathways and sustains hematopoietic stem cell function88
CD36, a signaling receptor and fatty acid transporter that regulates immune cell metabolism and fate87
Phenotypic and functional characterization of first-trimester human placental macrophages, Hofbauer cells87
B cells and cancer: To B or not to B?86
Tissue-resident memory T cells in tumor immunity and immunotherapy86
Activated microglia mitigate Aβ-associated tau seeding and spreading85
Macrophage morphology correlates with single-cell diversity and prognosis in colorectal liver metastasis85
Innate immune pathways and inflammation in hematopoietic aging, clonal hematopoiesis, and MDS82
Retrograde migration supplies resident memory T cells to lung-draining LN after influenza infection80
Tumor-derived IL-6 and trans-signaling among tumor, fat, and muscle mediate pancreatic cancer cachexia80
APOBEC3A catalyzes mutation and drives carcinogenesis in vivo80
Pro-inflammatory activation following demyelination is required for myelin clearance and oligodendrogenesis78
Microglia modulate blood flow, neurovascular coupling, and hypoperfusion via purinergic actions78
Glymphatic system clears extracellular tau and protects from tau aggregation and neurodegeneration77
Dnmt3a-mutated clonal hematopoiesis promotes osteoporosis77
STING agonist promotes CAR T cell trafficking and persistence in breast cancer76
The RNA m6A reader YTHDF2 controls NK cell antitumor and antiviral immunity75
Monocyte-derived macrophages promote breast cancer bone metastasis outgrowth75
The SIRPα–CD47 immune checkpoint in NK cells73
Single-cell RNA sequencing of murine islets shows high cellular complexity at all stages of autoimmune diabetes73
Tissue-resident memory T cell reactivation by diverse antigen-presenting cells imparts distinct functional responses73
Single cell analysis of M. tuberculosis phenotype and macrophage lineages in the infected lung71
Longevity and replenishment of human liver-resident memory T cells and mononuclear phagocytes70
Optimized gene engineering of murine CAR-T cells reveals the beneficial effects of IL-15 coexpression70
Distinct functions of tissue-resident and circulating memory Th2 cells in allergic airway disease69
Interleukin-17 in rheumatoid arthritis: Trials and tribulations68
Homozygous STAT2 gain-of-function mutation by loss of USP18 activity in a patient with type I interferonopathy68
Single-cell analyses identify circulating anti-tumor CD8 T cells and markers for their enrichment67
Stearoyl-CoA desaturase-1 impairs the reparative properties of macrophages and microglia in the brain67
Antigen-responsive CD4+ T cell clones contribute to the HIV-1 latent reservoir66
Tissue-specific pathways extrude activated ILC2s to disseminate type 2 immunity66
Brain transforms natural killer cells that exacerbate brain edema after intracerebral hemorrhage65
A committed tissue-resident memory T cell precursor within the circulating CD8+ effector T cell pool65
Sensing of endogenous nucleic acids by ZBP1 induces keratinocyte necroptosis and skin inflammation65
Early nasal type I IFN immunity against SARS-CoV-2 is compromised in patients with autoantibodies against type I IFNs65
Mitophagy-mediated adipose inflammation contributes to type 2 diabetes with hepatic insulin resistance64
SARS-CoV-2 breakthrough infection in vaccinees induces virus-specific nasal-resident CD8+ and CD4+ T cells of broad specificity64
SOAT1 promotes mevalonate pathway dependency in pancreatic cancer63
TREM2-dependent lipid droplet biogenesis in phagocytes is required for remyelination63
Single-cell analysis of human skin identifies CD14+ type 3 dendritic cells co-producing IL1B and IL23A in psoriasis63
Lung tumor MHCII immunity depends on in situ antigen presentation by fibroblasts61
A critical role for plasminogen in inflammation60
Inhibition of macrophage histone demethylase JMJD3 protects against abdominal aortic aneurysms60
Germinal center–dependent and –independent memory B cells produced throughout the immune response60
Autoantibody-mediated impairment of DNASE1L3 activity in sporadic systemic lupus erythematosus58
Neuronal interleukin-1 receptors mediate pain in chronic inflammatory diseases58
Endothelial LRP1 protects against neurodegeneration by blocking cyclophilin A58
IL-21 is a broad negative regulator of IgE class switch recombination in mouse and human B cells58
TCR signal strength defines distinct mechanisms of T cell dysfunction and cancer evasion57
Necroptosis restricts influenza A virus as a stand-alone cell death mechanism57
Alveolar macrophages rely on GM-CSF from alveolar epithelial type 2 cells before and after birth57
Tumor-derived soluble CD155 inhibits DNAM-1–mediated antitumor activity of natural killer cells56
Anti-tumor immunity in mismatch repair-deficient colorectal cancers requires type I IFN–driven CCL5 and CXCL1055
Intravenous administration of BCG protects mice against lethal SARS-CoV-2 challenge55
TIM3+ TRBV11-2 T cells and IFNγ signature in patrolling monocytes and CD16+ NK cells delineate MIS-C54
Recessive inborn errors of type I IFN immunity in children with COVID-19 pneumonia54
HSV1 VP1-2 deubiquitinates STING to block type I interferon expression and promote brain infection53
Sphingosine 1-phosphate receptor 5 (S1PR5) regulates the peripheral retention of tissue-resident lymphocytes53
Lipocalin-2 counteracts metabolic dysregulation in obesity and diabetes52
Immunogenicity and efficacy of one and two doses of Ad26.COV2.S COVID vaccine in adult and aged NHP52
Single-cell profiling reveals an endothelium-mediated immunomodulatory pathway in the eye choroid52
Nicotine promotes brain metastasis by polarizing microglia and suppressing innate immune function51
Immune asynchrony in COVID-19 pathogenesis and potential immunotherapies51
A TRPA1 inhibitor suppresses neurogenic inflammation and airway contraction for asthma treatment51
High microbiota reactivity of adult human intestinal IgA requires somatic mutations51
NK cell–derived GM-CSF potentiates inflammatory arthritis and is negatively regulated by CIS50
Dominant-negative mutations in human IL6ST underlie hyper-IgE syndrome50
β2-adrenergic signals downregulate the innate immune response and reduce host resistance to viral infection50
Mitochondrial metabolism supports resistance to IDH mutant inhibitors in acute myeloid leukemia49
Human autoantibodies underlying infectious diseases49
Type I interferon signaling mediates Mycobacterium tuberculosis–induced macrophage death49
Activation of group 2 innate lymphoid cells alleviates aging-associated cognitive decline48
Mechanosensing through YAP controls T cell activation and metabolism48
Anti–IFN-γ autoantibodies underlie disseminated Talaromyces marneffei infections48
Conserved meningeal lymphatic drainage circuits in mice and humans48
The pleiotropic roles of leptin in metabolism, immunity, and cancer48
AIM2 controls microglial inflammation to prevent experimental autoimmune encephalomyelitis47
LILRB4 suppresses immunity in solid tumors and is a potential target for immunotherapy47
Circulating clonally expanded T cells reflect functions of tumor-infiltrating T cells47
Normalization of cholesterol metabolism in spinal microglia alleviates neuropathic pain47
α-Synuclein modulates tau spreading in mouse brains45
Aged hematopoietic stem cells are refractory to bloodborne systemic rejuvenation interventions45
The GM-CSF–IRF5 signaling axis in eosinophils promotes antitumor immunity through activation of type 1 T cell responses45
Functional immune cell–astrocyte interactions45
Extracellular vesicle– and particle-mediated communication shapes innate and adaptive immune responses44
Membrane budding is a major mechanism of in vivo platelet biogenesis44
Human marginal zone B cell development from early T2 progenitors44
Single-cell lineage mapping of a diverse virus-specific naive CD4 T cell repertoire44
Vi-specific serological correlates of protection for typhoid fever43
Exit from germinal center to become quiescent memory B cells depends on metabolic reprograming and provision of a survival signal43
Effects of dietary restriction on neuroinflammation in neurodegenerative diseases43
NCKAP1L defects lead to a novel syndrome combining immunodeficiency, lymphoproliferation, and hyperinflammation43
Lipid-loaded tumor-associated macrophages sustain tumor growth and invasiveness in prostate cancer42
SIRT1–NOX4 signaling axis regulates cancer cachexia42
Yolk sac, but not hematopoietic stem cell–derived progenitors, sustain erythropoiesis throughout murine embryonic life42
A stem-loop RNA RIG-I agonist protects against acute and chronic SARS-CoV-2 infection in mice42
Suppression of local type I interferon by gut microbiota–derived butyrate impairs antitumor effects of ionizing radiation42
AKT-dependent NOTCH3 activation drives tumor progression in a model of mesenchymal colorectal cancer42
Activation of 4-1BBL+ B cells with CD40 agonism and IFNγ elicits potent immunity against glioblastoma40
Limited rejuvenation of aged hematopoietic stem cells in young bone marrow niche40
Helicobacter pylori metabolites exacerbate gastritis through C-type lectin receptors40
Efficient gene knockout in primary human and murine myeloid cells by non-viral delivery of CRISPR-Cas940
Lineage-specific regulation of inducible and constitutive mast cells in allergic airway inflammation40
BACH2 drives quiescence and maintenance of resting Treg cells to promote homeostasis and cancer immunosuppression39
Neutrophils and COVID-19: Nots, NETs, and knots39
TGF-β and Eomes control the homeostasis of CD8+ regulatory T cells39
Gut microbiota–driven brain Aβ amyloidosis in mice requires microglia39
Plasmodium falciparum erythrocyte membrane protein 1 variants induce cell swelling and disrupt the blood–brain barrier in cerebral malaria39
Plasmodium falciparum–specific IgM B cells dominate in children, expand with malaria, and produce functional IgM38
A robust platform for expansion and genome editing of primary human natural killer cells38
Loss of decay-accelerating factor triggers podocyte injury and glomerulosclerosis38
Synaptic restoration by cAMP/PKA drives activity-dependent neuroprotection to motoneurons in ALS38
In vivo labeling reveals continuous trafficking of TCF-1+ T cells between tumor and lymphoid tissue38
Chronic TREM2 activation exacerbates Aβ-associated tau seeding and spreading38
Preclinical validation of a potent γ-secretase modulator for Alzheimer’s disease prevention37
Profiling HPV-16–specific T cell responses reveals broad antigen reactivities in oropharyngeal cancer patients37
Lessons from Toxoplasma: Host responses that mediate parasite control and the microbial effectors that subvert them37
Feeding-induced hepatokine, Manf, ameliorates diet-induced obesity by promoting adipose browning via p38 MAPK pathway37
An NR2F1-specific agonist suppresses metastasis by inducing cancer cell dormancy37
Intestinal epithelial tuft cell induction is negated by a murine helminth and its secreted products37
Early type I IFN blockade improves the efficacy of viral vaccines36
USP22 promotes IRF3 nuclear translocation and antiviral responses by deubiquitinating the importin protein KPNA236
The architectural design of CD8+ T cell responses in acute and chronic infection: Parallel structures with divergent fates36
The T cell CD6 receptor operates a multitask signalosome with opposite functions in T cell activation35
Enhanced cGAS-STING–dependent interferon signaling associated with mutations in ATAD3A35
Multi-omic comparison of Alzheimer’s variants in human ESC–derived microglia reveals convergence at APOE35
MST4 kinase suppresses gastric tumorigenesis by limiting YAP activation via a non-canonical pathway35
Blocking inflammation on the way: Rationale for CXCR2 antagonists for the treatment of COVID-1934
Targeting CLK3 inhibits the progression of cholangiocarcinoma by reprogramming nucleotide metabolism34
A Fas-4-1BB fusion protein converts a death to a pro-survival signal and enhances T cell therapy34
Inflammatory signaling regulates hematopoietic stem and progenitor cell development and homeostasis34
Cell-intrinsic adrenergic signaling controls the adaptive NK cell response to viral infection34
NLRC4 inflammasome activation is NLRP3- and phosphorylation-independent during infection and does not protect from melanoma34
Inhibition of ADAM17 impairs endothelial cell necroptosis and blocks metastasis33
Adiponectin restrains ILC2 activation by AMPK-mediated feedback inhibition of IL-33 signaling33
Inflammasome signaling in human placental trophoblasts regulates immune defense against Listeria monocytogenes infection33
C-type lectin Mincle mediates cell death–triggered inflammation in acute kidney injury33
A population of proinflammatory T cells coexpresses αβ and γδ T cell receptors in mice and humans33
Blood transcriptomics reveal the evolution and resolution of the immune response in tuberculosis33
The current landscape of single-cell transcriptomics for cancer immunotherapy33
P38 kinases mediate NLRP1 inflammasome activation after ribotoxic stress response and virus infection33
Eosinophils are part of the granulocyte response in tuberculosis and promote host resistance in mice32
Gut microbiome stability and dynamics in healthy donors and patients with non-gastrointestinal cancers32
Rapid identification and characterization of infected cells in blood during chronic active Epstein-Barr virus infection32
Single-cell transcriptomic analysis of human colonic macrophages reveals niche-specific subsets32
Potent human broadly neutralizing antibodies to hepatitis B virus from natural controllers32
Reversal of emphysema by restoration of pulmonary endothelial cells32
Modulating the quantity of HIV Env-specific CD4 T cell help promotes rare B cell responses in germinal centers32
Gut microbiota, NLR proteins, and intestinal homeostasis31
Lysosomal cathepsin creates chimeric epitopes for diabetogenic CD4 T cells via transpeptidation31
Nicotinamide nucleotide transhydrogenase regulates mitochondrial metabolism in NSCLC through maintenance of Fe-S protein function31
Memory B cell responses to Omicron subvariants after SARS-CoV-2 mRNA breakthrough infection in humans31
Upregulation of VCAM-1 in lymphatic collectors supports dendritic cell entry and rapid migration to lymph nodes in inflammation31
TRIM24 facilitates antiviral immunity through mediating K63-linked TRAF3 ubiquitination31
AIM2 regulates anti-tumor immunity and is a viable therapeutic target for melanoma31
Life-threatening viral disease in a novel form of autosomal recessive IFNAR2 deficiency in the Arctic31
The metabolism-modulating activity of IL-17 signaling in health and disease30
Meteorin-like/Meteorin-β protects heart against cardiac dysfunction30
CD4+ T cells in the lungs of acute sarcoidosis patients recognize an Aspergillus nidulans epitope30
Combined deletion of Bap1, Nf2, and Cdkn2ab causes rapid onset of malignant mesothelioma in mice30
T reg–specific insulin receptor deletion prevents diet-induced and age-associated metabolic syndrome30
DNA damage contributes to neurotoxic inflammation in Aicardi-Goutières syndrome astrocytes30
T reg cell–intrinsic requirements for ST2 signaling in health and neuroinflammation30
Neutrophil-specific gain-of-function mutations in Nlrp3 promote development of cryopyrin-associated periodic syndrome29
Cerebral cavernous malformations are driven by ADAMTS5 proteolysis of versican29
Circadian immune circuits29
Critical requirement for BCR, BAFF, and BAFFR in memory B cell survival29
Circulating tumor cells: Ready for translation?29
Activation of the integrated stress response confers vulnerability to mitoribosome-targeting antibiotics in melanoma29
Autoantibodies against type I IFNs in patients with critical influenza pneumonia29
Group 2 innate lymphoid cells support hematopoietic recovery under stress conditions29
Vincristine-induced peripheral neuropathy is driven by canonical NLRP3 activation and IL-1β release29
CD4+ follicular regulatory T cells optimize the influenza virus–specific B cell response29
Role of adipose tissue macrophages in obesity-related disorders29
Chronic interleukin-1 exposure triggers selection for Cebpa-knockout multipotent hematopoietic progenitors29
PGD2 and CRTH2 counteract Type 2 cytokine–elicited intestinal epithelial responses during helminth infection29
A human mutation in STAT3 promotes type 1 diabetes through a defect in CD8+ T cell tolerance29
Immunotherapy during the acute SHIV infection of macaques confers long-term suppression of viremia29
A growth factor–expressing macrophage subpopulation orchestrates regenerative inflammation via GDF-1529
Glioma stem-like cells evade interferon suppression through MBD3/NuRD complex–mediated STAT1 downregulation29
PMN-derived netrin-1 attenuates cardiac ischemia-reperfusion injury via myeloid ADORA2B signaling29
Suppressive effects of the obese tumor microenvironment on CD8 T cell infiltration and effector function29
Platelets orchestrate the resolution of pulmonary inflammation in mice by T reg cell repositioning and macrophage education29
Influenza infection fortifies local lymph nodes to promote lung-resident heterosubtypic immunity28
The molecular and epigenetic mechanisms of innate lymphoid cell (ILC) memory and its relevance for asthma28
Human STAT3 variants underlie autosomal dominant hyper-IgE syndrome by negative dominance28
Simultaneously targeting cancer-associated fibroblasts and angiogenic vessel as a treatment for TNBC28
Biochemically deleterious human NFKB1 variants underlie an autosomal dominant form of common variable immunodeficiency28
Diagnostic blood RNA profiles for human acute spinal cord injury28
High-efficiency nonviral CRISPR/Cas9-mediated gene editing of human T cells using plasmid donor DNA28
Molecular architecture determines brain delivery of a transferrin receptor–targeted lysosomal enzyme27
Human resident memory T cells exit the skin and mediate systemic Th2-driven inflammation27
Type I IFNs and CD8 T cells increase intestinal barrier permeability after chronic viral infection27
Cyclin D3 drives inertial cell cycling in dark zone germinal center B cells27
Adoptive cell therapy: Living drugs against cancer27
Noncanonical STAT3 activity sustains pathogenic Th17 proliferation and cytokine response to antigen27
Constructing and deconstructing GATA2-regulated cell fate programs to establish developmental trajectories27
Foxo1 controls gut homeostasis and commensalism by regulating mucus secretion27
Integration features of intact latent HIV-1 in CD4+ T cell clones contribute to viral persistence27
Characterization of human FDCs reveals regulation of T cells and antigen presentation to B cells27
Serum HBsAg clearance has minimal impact on CD8+ T cell responses in mouse models of HBV infection27
A loss-of-function IFNAR1 allele in Polynesia underlies severe viral diseases in homozygotes27
Hypoxia-inducible factors individually facilitate inflammatory myeloid metabolism and inefficient cardiac repair27