Journal of Experimental Medicine

Article	Citations
SARS-CoV-2–triggered neutrophil extracellular traps mediate COVID-19 pathology	658
Neuroinvasion of SARS-CoV-2 in human and mouse brain	621
Inflammasomes are activated in response to SARS-CoV-2 infection and are associated with COVID-19 severity in patients	557
Measuring SARS-CoV-2 neutralizing antibody activity using pseudotyped and chimeric viruses	478
Lipid metabolism and cancer	391
Ferroptosis in infection, inflammation, and immunity	330
Mouse model of SARS-CoV-2 reveals inflammatory role of type I interferon signaling	328
Neutrophil extracellular traps infiltrate the lung airway, interstitial, and vascular compartments in severe COVID-19	273
Highly functional virus-specific cellular immune response in asymptomatic SARS-CoV-2 infection	261
Antibody potency, effector function, and combinations in protection and therapy for SARS-CoV-2 infection in vivo	258
Blood plasma phosphorylated-tau isoforms track CNS change in Alzheimer’s disease	255
Interleukin-17–induced neutrophil extracellular traps mediate resistance to checkpoint blockade in pancreatic cancer	236
Preexisting autoantibodies to type I IFNs underlie critical COVID-19 pneumonia in patients with APS-1	191
Microglia in Alzheimer's disease at single-cell level. Are there common patterns in humans and mice?	170
PD-1 restraint of regulatory T cell suppressive activity is critical for immune tolerance	156
SHP2 inhibition diminishes KRASG12C cycling and promotes tumor microenvironment remodeling	147
Dynamic innate immune response determines susceptibility to SARS-CoV-2 infection and early replication kinetics	146
Phenotypical and functional alteration of unconventional T cells in severe COVID-19 patients	145
Mutations in COPA lead to abnormal trafficking of STING to the Golgi and interferon signaling	140
Neutrophil phenotypes and functions in cancer: A consensus statement	138
Single-cell analysis of the cellular heterogeneity and interactions in the injured mouse spinal cord	138
Auto-antibodies to type I IFNs can underlie adverse reactions to yellow fever live attenuated vaccine	136
Analysis of classical neutrophils and polymorphonuclear myeloid-derived suppressor cells in cancer patients and tumor-bearing mice	135
Mapping and role of T cell response in SARS-CoV-2–infected mice	134
CD36, a signaling receptor and fatty acid transporter that regulates immune cell metabolism and fate	130

Tumor-infiltrating dendritic cell states are conserved across solid human cancers	129
Multi-omic profiling reveals widespread dysregulation of innate immunity and hematopoiesis in COVID-19	129
Inflammation as a regulator of hematopoietic stem cell function in disease, aging, and clonal selection	128
PKM2 promotes Th17 cell differentiation and autoimmune inflammation by fine-tuning STAT3 activation	127
β-Catenin induces transcriptional expression of PD-L1 to promote glioblastoma immune evasion	119
A defect in COPI-mediated transport of STING causes immune dysregulation in COPA syndrome	117
Glymphatic system clears extracellular tau and protects from tau aggregation and neurodegeneration	109
Activated microglia mitigate Aβ-associated tau seeding and spreading	108
Tissue-resident memory T cells in tumor immunity and immunotherapy	105
Persistent cellular immunity to SARS-CoV-2 infection	104
SARS-CoV-2 induces human plasmacytoid predendritic cell diversification via UNC93B and IRAK4	104
Phenotypic and functional characterization of first-trimester human placental macrophages, Hofbauer cells	103
Macrophage morphology correlates with single-cell diversity and prognosis in colorectal liver metastasis	103
SARS-CoV-2–related MIS-C: A key to the viral and genetic causes of Kawasaki disease?	102
B cells and cancer: To B or not to B?	102
Microglia modulate blood flow, neurovascular coupling, and hypoperfusion via purinergic actions	102
Innate immune pathways and inflammation in hematopoietic aging, clonal hematopoiesis, and MDS	101
Tumor-derived IL-6 and trans-signaling among tumor, fat, and muscle mediate pancreatic cancer cachexia	99
STING agonist promotes CAR T cell trafficking and persistence in breast cancer	99
The mRNA m6A reader YTHDF2 suppresses proinflammatory pathways and sustains hematopoietic stem cell function	98
APOBEC3A catalyzes mutation and drives carcinogenesis in vivo	94
The SIRPα–CD47 immune checkpoint in NK cells	89
Monocyte-derived macrophages promote breast cancer bone metastasis outgrowth	88
Dnmt3a-mutated clonal hematopoiesis promotes osteoporosis	87
The RNA m6A reader YTHDF2 controls NK cell antitumor and antiviral immunity	87
Optimized gene engineering of murine CAR-T cells reveals the beneficial effects of IL-15 coexpression	83
Lung tumor MHCII immunity depends on in situ antigen presentation by fibroblasts	82
Single cell analysis of M. tuberculosis phenotype and macrophage lineages in the infected lung	82
Alveolar macrophages rely on GM-CSF from alveolar epithelial type 2 cells before and after birth	80
TREM2-dependent lipid droplet biogenesis in phagocytes is required for remyelination	76
A committed tissue-resident memory T cell precursor within the circulating CD8+ effector T cell pool	76
Mitophagy-mediated adipose inflammation contributes to type 2 diabetes with hepatic insulin resistance	76
Single-cell analysis of human skin identifies CD14+ type 3 dendritic cells co-producing IL1B and IL23A in psoriasis	76
Single-cell analyses identify circulating anti-tumor CD8 T cells and markers for their enrichment	76
SOAT1 promotes mevalonate pathway dependency in pancreatic cancer	75
SARS-CoV-2 breakthrough infection in vaccinees induces virus-specific nasal-resident CD8+ and CD4+ T cells of broad specificity	75
Brain transforms natural killer cells that exacerbate brain edema after intracerebral hemorrhage	74
TCR signal strength defines distinct mechanisms of T cell dysfunction and cancer evasion	73
Inhibition of macrophage histone demethylase JMJD3 protects against abdominal aortic aneurysms	73
Autoantibody-mediated impairment of DNASE1L3 activity in sporadic systemic lupus erythematosus	71
Germinal center–dependent and –independent memory B cells produced throughout the immune response	69
Early nasal type I IFN immunity against SARS-CoV-2 is compromised in patients with autoantibodies against type I IFNs	68
Necroptosis restricts influenza A virus as a stand-alone cell death mechanism	66
Anti-tumor immunity in mismatch repair-deficient colorectal cancers requires type I IFN–driven CCL5 and CXCL10	66
Conserved meningeal lymphatic drainage circuits in mice and humans	66
Human autoantibodies underlying infectious diseases	64
Recessive inborn errors of type I IFN immunity in children with COVID-19 pneumonia	63
A TRPA1 inhibitor suppresses neurogenic inflammation and airway contraction for asthma treatment	63
Endothelial LRP1 protects against neurodegeneration by blocking cyclophilin A	63
Intravenous administration of BCG protects mice against lethal SARS-CoV-2 challenge	62

Sphingosine 1-phosphate receptor 5 (S1PR5) regulates the peripheral retention of tissue-resident lymphocytes	62
Type I interferon signaling mediates Mycobacterium tuberculosis–induced macrophage death	61
TIM3+ TRBV11-2 T cells and IFNγ signature in patrolling monocytes and CD16+ NK cells delineate MIS-C	60
Lipocalin-2 counteracts metabolic dysregulation in obesity and diabetes	59
Immunogenicity and efficacy of one and two doses of Ad26.COV2.S COVID vaccine in adult and aged NHP	59
Aged hematopoietic stem cells are refractory to bloodborne systemic rejuvenation interventions	58
Lipid-loaded tumor-associated macrophages sustain tumor growth and invasiveness in prostate cancer	57
Anti–IFN-γ autoantibodies underlie disseminated Talaromyces marneffei infections	57
Chronic TREM2 activation exacerbates Aβ-associated tau seeding and spreading	56
AIM2 controls microglial inflammation to prevent experimental autoimmune encephalomyelitis	56
LILRB4 suppresses immunity in solid tumors and is a potential target for immunotherapy	56
Functional immune cell–astrocyte interactions	56
High microbiota reactivity of adult human intestinal IgA requires somatic mutations	56
Mitochondrial metabolism supports resistance to IDH mutant inhibitors in acute myeloid leukemia	56
The pleiotropic roles of leptin in metabolism, immunity, and cancer	56
Normalization of cholesterol metabolism in spinal microglia alleviates neuropathic pain	55
Immune asynchrony in COVID-19 pathogenesis and potential immunotherapies	55
In vivo labeling reveals continuous trafficking of TCF-1+ T cells between tumor and lymphoid tissue	54
The GM-CSF–IRF5 signaling axis in eosinophils promotes antitumor immunity through activation of type 1 T cell responses	53
Effects of dietary restriction on neuroinflammation in neurodegenerative diseases	53
Exit from germinal center to become quiescent memory B cells depends on metabolic reprograming and provision of a survival signal	52
Suppression of local type I interferon by gut microbiota–derived butyrate impairs antitumor effects of ionizing radiation	51
Human marginal zone B cell development from early T2 progenitors	51
Inflammatory signaling regulates hematopoietic stem and progenitor cell development and homeostasis	51
α-Synuclein modulates tau spreading in mouse brains	50
A stem-loop RNA RIG-I agonist protects against acute and chronic SARS-CoV-2 infection in mice	50
Extracellular vesicle– and particle-mediated communication shapes innate and adaptive immune responses	50
AKT-dependent NOTCH3 activation drives tumor progression in a model of mesenchymal colorectal cancer	50
NCKAP1L defects lead to a novel syndrome combining immunodeficiency, lymphoproliferation, and hyperinflammation	50
PU.1 enforces quiescence and limits hematopoietic stem cell expansion during inflammatory stress	50
Circulating clonally expanded T cells reflect functions of tumor-infiltrating T cells	50
Single-cell lineage mapping of a diverse virus-specific naive CD4 T cell repertoire	48
Limited rejuvenation of aged hematopoietic stem cells in young bone marrow niche	48
Yolk sac, but not hematopoietic stem cell–derived progenitors, sustain erythropoiesis throughout murine embryonic life	48
Vi-specific serological correlates of protection for typhoid fever	47
Membrane budding is a major mechanism of in vivo platelet biogenesis	47
Gut microbiota–driven brain Aβ amyloidosis in mice requires microglia	47
Lineage-specific regulation of inducible and constitutive mast cells in allergic airway inflammation	46
Lessons from Toxoplasma: Host responses that mediate parasite control and the microbial effectors that subvert them	46
Plasmodium falciparum erythrocyte membrane protein 1 variants induce cell swelling and disrupt the blood–brain barrier in cerebral malaria	46
Plasmodium falciparum–specific IgM B cells dominate in children, expand with malaria, and produce functional IgM	46
Loss of decay-accelerating factor triggers podocyte injury and glomerulosclerosis	45
An NR2F1-specific agonist suppresses metastasis by inducing cancer cell dormancy	45
Enhanced cGAS-STING–dependent interferon signaling associated with mutations in ATAD3A	45
Activation of 4-1BBL+ B cells with CD40 agonism and IFNγ elicits potent immunity against glioblastoma	44
Helicobacter pylori metabolites exacerbate gastritis through C-type lectin receptors	44
Feeding-induced hepatokine, Manf, ameliorates diet-induced obesity by promoting adipose browning via p38 MAPK pathway	44
Preclinical validation of a potent γ-secretase modulator for Alzheimer’s disease prevention	44
Intestinal epithelial tuft cell induction is negated by a murine helminth and its secreted products	44
Single-cell transcriptomic analysis of human colonic macrophages reveals niche-specific subsets	44
Blood transcriptomics reveal the evolution and resolution of the immune response in tuberculosis	44
The architectural design of CD8+ T cell responses in acute and chronic infection: Parallel structures with divergent fates	44
DNA damage contributes to neurotoxic inflammation in Aicardi-Goutières syndrome astrocytes	44
A robust platform for expansion and genome editing of primary human natural killer cells	44
Autoantibodies against type I IFNs in patients with critical influenza pneumonia	44
Reversal of emphysema by restoration of pulmonary endothelial cells	43
Gut microbiome stability and dynamics in healthy donors and patients with non-gastrointestinal cancers	43
TGF-β and Eomes control the homeostasis of CD8+ regulatory T cells	42
The metabolism-modulating activity of IL-17 signaling in health and disease	41
Neutrophils and COVID-19: Nots, NETs, and knots	41
A Fas-4-1BB fusion protein converts a death to a pro-survival signal and enhances T cell therapy	41
Early type I IFN blockade improves the efficacy of viral vaccines	41
P38 kinases mediate NLRP1 inflammasome activation after ribotoxic stress response and virus infection	41
The current landscape of single-cell transcriptomics for cancer immunotherapy	39
A growth factor–expressing macrophage subpopulation orchestrates regenerative inflammation via GDF-15	39
Eosinophils are part of the granulocyte response in tuberculosis and promote host resistance in mice	39
Adiponectin restrains ILC2 activation by AMPK-mediated feedback inhibition of IL-33 signaling	39
Profiling HPV-16–specific T cell responses reveals broad antigen reactivities in oropharyngeal cancer patients	39
Upregulation of VCAM-1 in lymphatic collectors supports dendritic cell entry and rapid migration to lymph nodes in inflammation	38
Rapid identification and characterization of infected cells in blood during chronic active Epstein-Barr virus infection	38
Life-threatening viral disease in a novel form of autosomal recessive IFNAR2 deficiency in the Arctic	38
Memory B cell responses to Omicron subvariants after SARS-CoV-2 mRNA breakthrough infection in humans	38
Human resident memory T cells exit the skin and mediate systemic Th2-driven inflammation	38
The T cell CD6 receptor operates a multitask signalosome with opposite functions in T cell activation	38
A high OXPHOS CD8 T cell subset is predictive of immunotherapy resistance in melanoma patients	38
Inhibition of ADAM17 impairs endothelial cell necroptosis and blocks metastasis	37
Gut microbiota, NLR proteins, and intestinal homeostasis	37
Lysosomal cathepsin creates chimeric epitopes for diabetogenic CD4 T cells via transpeptidation	37
Integration features of intact latent HIV-1 in CD4+ T cell clones contribute to viral persistence	37
Circadian immune circuits	37

Cancer cell CCR2 orchestrates suppression of the adaptive immune response	36
A partial form of inherited human USP18 deficiency underlies infection and inflammation	36
C-type lectin Mincle mediates cell death–triggered inflammation in acute kidney injury	36
High-efficiency nonviral CRISPR/Cas9-mediated gene editing of human T cells using plasmid donor DNA	36
Suppressive effects of the obese tumor microenvironment on CD8 T cell infiltration and effector function	36
Meteorin-like/Meteorin-β protects heart against cardiac dysfunction	36
Inflammasome signaling in human placental trophoblasts regulates immune defense against Listeria monocytogenes infection	36
Diagnostic blood RNA profiles for human acute spinal cord injury	35
Modulating the quantity of HIV Env-specific CD4 T cell help promotes rare B cell responses in germinal centers	35
Treatment of two infants with PIK3CA-related overgrowth spectrum by alpelisib	35
CD4+ T cells in the lungs of acute sarcoidosis patients recognize an Aspergillus nidulans epitope	35
Multi-omic comparison of Alzheimer’s variants in human ESC–derived microglia reveals convergence at APOE	35
A human mutation in STAT3 promotes type 1 diabetes through a defect in CD8+ T cell tolerance	35
The molecular and epigenetic mechanisms of innate lymphoid cell (ILC) memory and its relevance for asthma	35
TGF-β regulates the stem-like state of PD-1+ TCF-1+ virus-specific CD8 T cells during chronic infection	35
T reg cell–intrinsic requirements for ST2 signaling in health and neuroinflammation	34
PGD2 and CRTH2 counteract Type 2 cytokine–elicited intestinal epithelial responses during helminth infection	34
Serum HBsAg clearance has minimal impact on CD8+ T cell responses in mouse models of HBV infection	34
Biochemically deleterious human NFKB1 variants underlie an autosomal dominant form of common variable immunodeficiency	34
Blocking inflammation on the way: Rationale for CXCR2 antagonists for the treatment of COVID-19	34
Characterization of human FDCs reveals regulation of T cells and antigen presentation to B cells	34
LYVE1+ macrophages of murine peritoneal mesothelium promote omentum-independent ovarian tumor growth	34
CD4+ follicular regulatory T cells optimize the influenza virus–specific B cell response	34
Role of adipose tissue macrophages in obesity-related disorders	34
Constrained chromatin accessibility in PU.1-mutated agammaglobulinemia patients	34
Influenza infection fortifies local lymph nodes to promote lung-resident heterosubtypic immunity	33
BTK operates a phospho-tyrosine switch to regulate NLRP3 inflammasome activity	33
Clonal lineage tracing reveals mechanisms skewing CD8+ T cell fate decisions in chronic infection	33
AIM2 regulates anti-tumor immunity and is a viable therapeutic target for melanoma	33
Circulating tumor cells: Ready for translation?	33
Matrix compliance permits NF-κB activation to drive therapy resistance in breast cancer	33
Potent human broadly SARS-CoV-2–neutralizing IgA and IgG antibodies effective against Omicron BA.1 and BA.2	33
Platelets orchestrate the resolution of pulmonary inflammation in mice by T reg cell repositioning and macrophage education	33
Hypoxia-inducible factors individually facilitate inflammatory myeloid metabolism and inefficient cardiac repair	32
Foxo1 controls gut homeostasis and commensalism by regulating mucus secretion	32
Noncanonical STAT3 activity sustains pathogenic Th17 proliferation and cytokine response to antigen	32
Chronic interleukin-1 exposure triggers selection for Cebpa-knockout multipotent hematopoietic progenitors	32
Cyclin D3 drives inertial cell cycling in dark zone germinal center B cells	32
Arachnoid granulations are lymphatic conduits that communicate with bone marrow and dura-arachnoid stroma	32
Activation of the integrated stress response confers vulnerability to mitoribosome-targeting antibiotics in melanoma	32
Monocytes transition to macrophages within the inflamed vasculature via monocyte CCR2 and endothelial TNFR2	32
PMN-derived netrin-1 attenuates cardiac ischemia-reperfusion injury via myeloid ADORA2B signaling	32
Human germline heterozygous gain-of-functionSTAT6variants cause severe allergic disease	32
Human STAT3 variants underlie autosomal dominant hyper-IgE syndrome by negative dominance	32
Sustained androgen receptor signaling is a determinant of melanoma cell growth potential and tumorigenesis	32
Critical requirement for BCR, BAFF, and BAFFR in memory B cell survival	32
Molecular architecture determines brain delivery of a transferrin receptor–targeted lysosomal enzyme	31
Simultaneously targeting cancer-associated fibroblasts and angiogenic vessel as a treatment for TNBC	31
Vincristine-induced peripheral neuropathy is driven by canonical NLRP3 activation and IL-1β release	31
CD16+CD163+ monocytes traffic to sites of inflammation during necrotizing enterocolitis in premature infants	31
Neutrophil-specific gain-of-function mutations in Nlrp3 promote development of cryopyrin-associated periodic syndrome	31
Interplay of vascular endothelial growth factor receptors in organ-specific vessel maintenance	31
CD4+ T helper 2 cells suppress breast cancer by inducing terminal differentiation	31
Genome-wide mutational signatures revealed distinct developmental paths for human B cell lymphomas	31
GPX4 regulates cellular necrosis and host resistance in Mycobacterium tuberculosis infection	31
The long noncoding RNA Malat1 regulates CD8+ T cell differentiation by mediating epigenetic repression	30
Immunotherapy during the acute SHIV infection of macaques confers long-term suppression of viremia	30
The aryl hydrocarbon receptor contributes to tissue adaptation of intestinal eosinophils in mice	30
Immune checkpoint inhibitors	30
Group 2 innate lymphoid cells support hematopoietic recovery under stress conditions	30
Elevating microglia TREM2 reduces amyloid seeding and suppresses disease-associated microglia	30
Cerebral cavernous malformations are driven by ADAMTS5 proteolysis of versican	30
CD47 blockade enhances the efficacy of intratumoral STING-targeting therapy by activating phagocytes	30
A loss-of-function IFNAR1 allele in Polynesia underlies severe viral diseases in homozygotes	30
The transcription factor HIF-1α mediates plasticity of NKp46+ innate lymphoid cells in the gut	29
Type I IFNs and CD8 T cells increase intestinal barrier permeability after chronic viral infection	29
CCR2/CCR5 inhibitor permits the radiation-induced effector T cell infiltration in pancreatic adenocarcinoma	29
Impaired IL-23–dependent induction of IFN-γ underlies mycobacterial disease in patients with inherited TYK2 deficiency	29
Constructing and deconstructing GATA2-regulated cell fate programs to establish developmental trajectories	29
Adoptive cell therapy: Living drugs against cancer	29
Sleep exerts lasting effects on hematopoietic stem cell function and diversity	29
The dark side of the gut: Virome–host interactions in intestinal homeostasis and disease	29
Chronic T cell proliferation in brains after stroke could interfere with the efficacy of immunotherapies	29
CCL5-producing migratory dendritic cells guide CCR5+ monocytes into the draining lymph nodes	28
GIMAP5 maintains liver endothelial cell homeostasis and prevents portal hypertension	28
Altered glycosylation in pancreatic cancer and beyond	28
Broad and potent neutralizing human antibodies to tick-borne flaviviruses protect mice from disease	28
Broader Epstein–Barr virus–specific T cell receptor repertoire in patients with multiple sclerosis	28
Identification of conserved SARS-CoV-2 spike epitopes that expand public cTfh clonotypes in mild COVID-19 patients	28
Impaired immune response drives age-dependent severity of COVID-19	28
Chronic viral infections persistently alter marrow stroma and impair hematopoietic stem cell fitness	28
Systematic memory B cell archiving and random display shape the human splenic marginal zone throughout life	28
Diminished cell proliferation promotes natural killer cell adaptive-like phenotype by limiting FcεRIγ expression	28
CD127 imprints functional heterogeneity to diversify monocyte responses in inflammatory diseases	28
Synaptic pruning of murine adult-born neurons by microglia depends on phosphatidylserine	28
CD116+ fetal precursors migrate to the perinatal lung and give rise to human alveolar macrophages	28
Human NLRP1: From the shadows to center stage	28
Loss of ZBTB24 impairs nonhomologous end-joining and class-switch recombination in patients with ICF syndrome	28
Transmembrane TNF drives osteoproliferative joint inflammation reminiscent of human spondyloarthritis	27
Modeling human yolk sac hematopoiesis with pluripotent stem cells	27
Elongated neutrophil-derived structures are blood-borne microparticles formed by rolling neutrophils during sepsis	27
Targeting mechanosensitive MDM4 promotes lung fibrosis resolution in aged mice	27
ASC deglutathionylation is a checkpoint for NLRP3 inflammasome activation	27
Deciphering and predicting CD4+ T cell immunodominance of influenza virus hemagglutinin	27
Immunodominant antibody germlines in COVID-19	27