Journal of Experimental Medicine

Article	Citations
Antigen-independent, autonomous B cell receptor signaling drives activated B cell DLBCL	501
Host factor TIMP1 sustains long-lasting myeloid-biased hematopoiesis after severe infection	228
Early innate role for CD8αα+ cells in tuberculosis	223
Neutralizing antibodies protect mice against Venezuelan equine encephalitis virus aerosol challenge	202
The pathogenic role of retinoid nuclear receptor signaling in cancer and metabolic syndromes	192
Inhibition of astrocytic DRD2 suppresses CNS inflammation in an animal model of multiple sclerosis	183
Protection of ischemic white matter and oligodendrocytes in mice by 3K3A-activated protein C	175
Intestinal epithelial c-Maf expression determines enterocyte differentiation and nutrient uptake in mice	163
Bromodomain protein BRD4 directs and sustains CD8 T cell differentiation during infection	158
SARS-CoV-2 Spike protein suppresses CTL-mediated killing by inhibiting immune synapse assembly	156
Primary tumor–derived systemic nANGPTL4 inhibits metastasis	139
IL-21 shapes germinal center polarization via light zone B cell selection and cyclin D3 upregulation	134
Prenatally derived macrophages support choroidal health and decline in age-related macular degeneration	124
Human STAT3 variants underlie autosomal dominant hyper-IgE syndrome by negative dominance	119
ASC deglutathionylation is a checkpoint for NLRP3 inflammasome activation	118
B cell receptor ligation induces IgE plasma cell elimination	117
Sphingosine 1-phosphate receptor 5 (S1PR5) regulates the peripheral retention of tissue-resident lymphocytes	116
The microbial one-hit wonder	108
Antibody feedback contributes to facilitating the development of Omicron-reactive memory B cells in SARS-CoV-2 mRNA vaccinees	107
RORγt eTACs mediate oral tolerance and Treg induction	105
Stage-specific action of Runx1 and GATA3 controls silencing of PU.1 expression in mouse pro–T cells	101
Inflammation as a regulator of hematopoietic stem cell function in disease, aging, and clonal selection	98
High burden of viruses and bacterial pathobionts drives heightened nasal innate immunity in children	95
TCR signal strength defines distinct mechanisms of T cell dysfunction and cancer evasion	92
Differential IL-12 signaling induces human natural killer cell activating receptor-mediated ligand-specific expansion	89

An iron-rich subset of macrophages promotes tumor growth through a Bach1-Ednrb axis	85
Aged hematopoietic stem cells are refractory to bloodborne systemic rejuvenation interventions	81
The genetic background shapes the susceptibility to mitochondrial dysfunction and NASH progression	80
Hypoxia induces adrenomedullin from lung epithelia, stimulating ILC2 inflammation and immunity	80
Role of adipose tissue macrophages in obesity-related disorders	79
A high OXPHOS CD8 T cell subset is predictive of immunotherapy resistance in melanoma patients	77
Non-professional efferocytosis of Salmonella-infected intestinal epithelial cells in the neonatal host	75
Making memories with Bcl-6	75
pDCs, type 1 IFN, and the female predileXion of SSc	74
Dual role of vascular endothelial growth factor-C in post-stroke recovery	74
IFNγ score–based neoadjuvant immunotherapy for stage III melanoma	74
Systems-level conservation of the proximal TCR signaling network of mice and humans	73
Correction: Segmented filamentous bacteria–induced epithelial MHCII regulates cognate CD4+ IELs and epithelial turnover	73
TIGIT mediates activation-induced cell death of ILC2s during chronic airway allergy	73
Challenges in TB research	73
Obesity alters monocyte developmental trajectories to enhance metastasis	72
Implication of folate deficiency in CYP2U1 loss of function	70
Posttranscriptional regulation of ILC2 homeostatic function via tristetraprolin	67
Transit-amplifying cells control R-spondins in the mouse crypt to modulate intestinal stem cell proliferation	67
Single cell analysis of M. tuberculosis phenotype and macrophage lineages in the infected lung	66
A human STAT3 gain-of-function variant drives local Th17 dysregulation and skin inflammation in mice	64
Lymphatic chain gradients regulate the magnitude and heterogeneity of T cell responses to vaccination	63
CD8+ T cell depletion prevents neuropathology in a mouse model of globoid cell leukodystrophy	63
Loss of ATG7 in microglia impairs UPR, triggers ferroptosis, and weakens amyloid pathology control	63
CXCL12+ dermal fibroblasts promote neutrophil recruitment and host defense by recognition of IL-17	62
IEC-intrinsic IL-1R signaling holds dual roles in regulating intestinal homeostasis and inflammation	60
NFAT5 governs cellular plasticity-driven resistance to KRAS-targeted therapy in pancreatic cancer	60
Promiscuous recognition of MR1 drives self-reactive mucosal-associated invariant T cell responses	59
E3 ligase MKRN3 is a tumor suppressor regulating PABPC1 ubiquitination in non–small cell lung cancer	59
Immunomolecular and reactivity landscapes of gut IgA subclasses in homeostasis and inflammatory bowel disease	59
CD150-dependent hematopoietic stem cell sensing of Brucella instructs myeloid commitment	59
Spatiotemporal dynamics of fetal liver hematopoietic niches	58
Extracellular vesicle– and particle-mediated communication shapes innate and adaptive immune responses	58
Dietary intervention preserves β cell function in mice through CTCF-mediated transcriptional reprogramming	56
Memory B cell responses to Omicron subvariants after SARS-CoV-2 mRNA breakthrough infection in humans	56
Amino acid availability acts as a metabolic rheostat to determine the magnitude of ILC2 responses	56
Pleiotrophin drives a prometastatic immune niche in breast cancer	55
Human autoantibodies underlying infectious diseases	54
TIMP1 expression underlies sex disparity in liver metastasis and survival in pancreatic cancer	54
Deficiency for SAMHD1 activates MDA5 in a cGAS/STING-dependent manner	54
Altered glycosylation in pancreatic cancer and beyond	54
Gut epithelial IL-27 confers intestinal immunity through the induction of intraepithelial lymphocytes	53
T2B or not to B: Calming neutrophils offshore	53
Inherited human ITK deficiency impairs IFN-γ immunity and underlies tuberculosis	53
Tingible body macrophages: Gargantuan chameleons of the germinal center	53
MYC is a clinically significant driver of mTOR inhibitor resistance in breast cancer	52
A twist in the tail: Of T cell subsets and disease	51
Nina Cabezas Wallscheid: Enjoying the freedom to decide my research path	50
Functional specialization of short-lived and long-lived macrophage subsets in human tonsils	50
Michelle Linterman: We are always learning	50

Somatic gain-of-function mutations in BUD13 promote oncogenesis by disrupting Fbw7 function	50
Augmenting neurogenesis rescues memory impairments in Alzheimer’s disease by restoring the memory-storing neurons	49
MYO1F in neutrophils is required for the response to immune checkpoint blockade therapy	49
Alveolar macrophages rely on GM-CSF from alveolar epithelial type 2 cells before and after birth	49
Protein arginine methyltransferase 1 regulates B cell fate after positive selection in the germinal center in mice	49
CXCR4+ Treg cells control serum IgM levels and natural IgM autoantibody production by B-1 cells in the bone marrow	49
How decreasing T cell signaling unexpectedly results in autoimmunity	49
Protective fibroblastic niches in secondary lymphoid organs	48
Correction: Role of affinity in plasma cell development in the germinal center light zone	48
Ki67 deficiency impedes chromatin accessibility and BCR gene rearrangement	48
NK cell expansion requires HuR and mediates control of solid tumors and long-term virus infection	48
Sara Suliman: Science is better when it’s shared	48
CTLA4 prohibits T cells from cross-dressing	48
TET2–STAT3–CXCL5 nexus promotes neutrophil lipid transfer to fuel lung adeno-to-squamous transition	47
Immature B cell homing shapes human lymphoid tissue structure and function	47
Regulatory T cells converted from Th1 cells in tumors suppress cancer immunity via CD39	46
Targeting neuroinflammation in neuropathic pain and opioid use	46
Gain-of-function human UNC93B1 variants cause systemic lupus erythematosus and chilblain lupus	46
Correction: Mouse model of SARS-CoV-2 reveals inflammatory role of type I interferon signaling	46
The common HAQ STING allele prevents clinical penetrance of COPA syndrome	46
Activating NO–sGC crosstalk in the mouse vascular niche promotes vascular integrity and mitigates acute lung injury	46
Changing behind the scenes	46
Tumor-derived OBP2A promotes prostate cancer castration resistance	46
Synaptic pruning of murine adult-born neurons by microglia depends on phosphatidylserine	46
Differential impact of lymphatic outflow pathways on cerebrospinal fluid homeostasis	44
CAR-T cell manufacturing: Major process parameters and next-generation strategies	44
Macrophages in the synovial lining niche initiate neutrophil recruitment and articular inflammation	44
Transient astrocytic mGluR5 expression drives synaptic plasticity and subsequent chronic pain in mice	44
Altered X-chromosome inactivation of the TLR7/8 locus and heterogeneity of pDCs in systemic sclerosis	44
DNA damage contributes to neurotoxic inflammation in Aicardi-Goutières syndrome astrocytes	43
Loss of ARID3A perturbs intestinal epithelial proliferation–differentiation ratio and regeneration	43
Hnf4 activates mimetic-cell enhancers to recapitulate gut and liver development within the thymus	43
TCR signaling induces STAT3 phosphorylation to promote TH17 cell differentiation	43
Functional vulnerability of liver macrophages to capsules defines virulence of blood-borne bacteria	43
Women in STEM becoming independent: The journey to independence is an immensely gratifying odyssey	43
Coxsackievirus A10 impairs nail regeneration and induces onychomadesis by mimicking DKK1 to attenuate Wnt signaling	42
Distinct fibroblast progenitor subpopulation expedites regenerative mucosal healing by immunomodulation	42
Dynamic Foxp3–chromatin interaction controls tunable Treg cell function	42
Hemifacial myohyperplasia is due to somatic muscular PIK3CA gain-of-function mutations and responds to pharmacological inhibition	41
Single-cell imaging of T cell immunotherapy responses in vivo	41
Disruption of thymic central tolerance by infection with murine roseolovirus induces autoimmune gastritis	41
Correction: Precursor central memory versus effector cell fate and naïve CD4+ T cell heterogeneity	40
Perfecting antigen prediction	40
Correction: Antigen-presenting autoreactive B cells activate regulatory T cells and suppress autoimmune arthritis in mice	40
Correction: Profiling HPV-16–specific T cell responses reveals broad antigen reactivities in oropharyngeal cancer patients	40
Addendum: Resolvins suppress tumor growth and enhance cancer therapy	40
Correction: Context-dependent effects of IL-2 rewire immunity into distinct cellular circuits	40
A cell-free antigen processing system informs HIV-1 epitope selection and vaccine design	40
Age- and diet-instructed metabolic rewiring of the tumor–immune microenvironment	39
A path forward for Staphylococcus aureus vaccine development	39
Succinate-producing microbiota drives tuft cell hyperplasia to protect against Clostridioides difficile	39
Intravital imaging of pulmonary lymphatics in inflammation and metastatic cancer	39
Dominant negative OTULIN-related autoinflammatory syndrome	38
Competitive fungal commensalism mitigates candidiasis pathology	38
Cigarette smoke components modulate the MR1–MAIT axis	38
Identification of conserved SARS-CoV-2 spike epitopes that expand public cTfh clonotypes in mild COVID-19 patients	38
TREM2-dependent lipid droplet biogenesis in phagocytes is required for remyelination	38
Intestinal epithelial tuft cell induction is negated by a murine helminth and its secreted products	38
Chronic activation of pDCs in autoimmunity is linked to dysregulated ER stress and metabolic responses	38
Vision rescue via unconstrained in vivo prime editing in degenerating neural retinas	37
Single-cell analysis of the cellular heterogeneity and interactions in the injured mouse spinal cord	37
CD163+ macrophages monitor enhanced permeability at the blood–dorsal root ganglion barrier	37
Trapping of CDC42 C-terminal variants in the Golgi drives pyrin inflammasome hyperactivation	37
Stalled but not forgotten: Bacterial exotoxins inhibit translation to activate NLRP1	36
Rare SH2B3 coding variants in lupus patients impair B cell tolerance and predispose to autoimmunity	36
Individuals with JAK1 variants are affected by syndromic features encompassing autoimmunity, atopy, colitis, and dermatitis	36
Iron TAMs: The fallen protectors	36
HMCN1 variants aggravate epidermolysis bullosa simplex phenotype	36
Megakaryopoiesis impairment through acute innate immune signaling activation by azacitidine	36
Trav15-dv6 family Tcrd rearrangements diversify the Tcra repertoire	35
Immunologic signatures of response and resistance to nivolumab with ipilimumab in advanced metastatic cancer	35
Nucleotide modifications enable rational design of TLR7-selective ligands by blocking RNase cleavage	35
Recessive inborn errors of type I IFN immunity in children with COVID-19 pneumonia	35
A TLR7 antagonist restricts interferon-dependent and -independent immunopathology in a mouse model of severe influenza	35
Charting the meningeal lymphatic network	35
Lysophosphatidylserines derived from microbiota in Crohn’s disease elicit pathological Th1 response	34
RAC2 gain-of-function variants causing inborn error of immunity drive NLRP3 inflammasome activation	34
Repurposing a tricyclic antidepressant in tumor and metabolism disease treatment through fatty acid uptake inhibition	34
CD4+ T helper 2 cells suppress breast cancer by inducing terminal differentiation	34
Inhibitory pattern recognition receptors	34

Enhanced IL-2 in early life limits the development of TFH and protective antiviral immunity	33
Fueling the fire in the gut	33
Urine scRNAseq reveals new insights into the bladder tumor immune microenvironment	33
Macro-clusters: CD301b+ DCs prime Th2 responses	33
Eating away T cell responses in lung cancer	33
Distinct molecular profiles drive multifaceted characteristics of colorectal cancer metastatic seeds	33
VEGF-C prophylaxis favors lymphatic drainage and modulates neuroinflammation in a stroke model	33
No added sugar: CCDC134 stabilizes ER chaperone Gp96 for TLR biogenesis	32
The PML hub: An emerging actor of leukemia therapies	32
Activated PI3Kδ signals compromise plasma cell survival via limiting autophagy and increasing ER stress	32
Correction: TRAF3–EWSR1 signaling axis acts as a checkpoint on germinal center responses	32
Platelets orchestrate the resolution of pulmonary inflammation in mice by T reg cell repositioning and macrophage education	32
Glucosamine amends CNS pathology in mucopolysaccharidosis IIIC mouse expressing misfolded HGSNAT	32
Correction: Mapping and role of T cell response in SARS-CoV-2–infected mice	32
Use of 3M-052-AF with Alum adjuvant in HIV trimer vaccine induces human autologous neutralizing antibodies	32
Th17-to-Tfh plasticity during periodontitis limits disease pathology	31
Role of PRC2 in the stochastic expression of Aire target genes and development of mimetic cells in the thymus	31
Clonal lineage tracing reveals mechanisms skewing CD8+ T cell fate decisions in chronic infection	31
Lymph node fibroblastic reticular cells regulate differentiation and function of CD4 T cells via CD25	31
Pathogenic autoantibodies to IFN-γ act through the impedance of receptor assembly and Fc-mediated response	31
Inborn errors of TLR3- or MDA5-dependent type I IFN immunity in children with enterovirus rhombencephalitis	30
PGD2 and CRTH2 counteract Type 2 cytokine–elicited intestinal epithelial responses during helminth infection	30
Tumor-associated neutrophils attenuate the immunosensitivity of hepatocellular carcinoma	30
Microbiota and adipocyte mitochondrial damage in type 2 diabetes are linked by Mmp12+ macrophages	30
Human CARMIL2 deficiency underlies a broader immunological and clinical phenotype than CD28 deficiency	30
Intercrypt sentinel macrophages tune antibacterial NF-κB responses in gut epithelial cells via TNF	30
Stopping the fat: Repurposing an antidepressant for cancer treatment	29
STAT3 gain of function: Too much of a good thing in the skin!	29
Loss of direct adrenergic innervation after peripheral nerve injury causes lymph node expansion through IFN-γ	29
Baseline colitogenicity and acute perturbations of gut microbiota in immunotherapy-related colitis	29
KLF2 expression in IgG plasma cells at their induction site regulates the migration program	29
The X factor in neurodegeneration	29
The stunning clodronate	28
I SPI1 something needed for B cells	28
IL-17A–producing γδT cells promote muscle regeneration in a microbiota-dependent manner	28
Act1 drives chemoresistance via regulation of antioxidant RNA metabolism and redox homeostasis	28
Mechanosensing regulates pDC activation in the skin through NRF2 activation	28
Linda-Gail Bekker: Mentorship is critical for anyone in STEM	28
Intravenous administration of BCG protects mice against lethal SARS-CoV-2 challenge	27
Delineating a serotonin 1B receptor circuit for appetite suppression in mice	27
PARP7 inhibits type I interferon signaling to prevent autoimmunity and lung disease	27
Recurrent infection transiently expands human tissue T cells while maintaining long-term homeostasis	27
Identifying genetic errors of immunity due to mosaicism	27
A newly characterized malaria antigen on erythrocyte and merozoite surfaces induces parasite inhibitory antibodies	26
Periductal fibroblasts participate in liver homeostasis, fibrosis, and tumorigenesis	26
Landscape of mast cell populations across organs in mice and humans	26
Analyzing signaling activity and function in hematopoietic cells	26
OX40L-expressing recombinant modified vaccinia virus Ankara induces potent antitumor immunity via reprogramming Tregs	26
Guardians of the oral barriers	26
Modeling memory B cell responses in a lymphoid organ-chip to evaluate mRNA vaccine boosting	26
NADPH oxidase exerts a B cell–intrinsic contribution to lupus risk by modulating endosomal TLR signals	26
Mitochondrial pyruvate metabolism and glutaminolysis toggle steady-state and emergency myelopoiesis	26
Lymph node metastasis: An immunological burden	26
A TNF-IL-1 circuit controls Yersinia within intestinal pyogranulomas	26
Mutations disrupting the kinase domain of IKKα lead to immunodeficiency and immune dysregulation in humans	25
Lymphatic transport in anti-tumor immunity and metastasis	25
CD47 blockade enhances the efficacy of intratumoral STING-targeting therapy by activating phagocytes	25
OTULIN and Muller’s morphs	25
BATF represses BIM to sustain tolerant T cells in the periphery	25
PD-1 and TIM-3 differentially regulate subsets of mouse IL-17A–producing γδ T cells	25
Stability and heterogeneity in the antimicrobiota reactivity of human milk-derived immunoglobulin A	25
A half-century of research on tuberculosis: Successes and challenges	25
GIMAP6 regulates autophagy, immune competence, and inflammation in mice and humans	24
A viral E3 ubiquitin ligase produced by herpes simplex virus 1 inhibits the NLRP1 inflammasome	24
Helios represses megakaryocyte priming in hematopoietic stem and progenitor cells	24
Five decades of natural killer cell discovery	24
LYVE1+ macrophages of murine peritoneal mesothelium promote omentum-independent ovarian tumor growth	24
Trained immunity of alveolar macrophages enhances injury resolution via KLF4-MERTK-mediated efferocytosis	24
An engineered concealed IL-15-R elicits tumor-specific CD8+T cell responses through PD-1-cis delivery	24
Tumor cell–intrinsic Piezo2 drives radioresistance by impairing CD8+ T cell stemness maintenance	24
Single-cell transcriptomic analysis of human colonic macrophages reveals niche-specific subsets	24
Modulation of tissue resident memory T cells by glucocorticoids after acute cellular rejection in lung transplantation	24