Journal of Experimental Medicine

Article	Citations
Epitope and HLA specificity of human TCRs against Plasmodium falciparum circumsporozoite protein	269
An iron-rich subset of macrophages promotes tumor growth through a Bach1-Ednrb axis	232
Inhibition of astrocytic DRD2 suppresses CNS inflammation in an animal model of multiple sclerosis	189
S1PR1, an endothelial-immune influencer	178
SARS-CoV-2 Spike protein suppresses CTL-mediated killing by inhibiting immune synapse assembly	139
Intestinal epithelial c-Maf expression determines enterocyte differentiation and nutrient uptake in mice	129
Protection of ischemic white matter and oligodendrocytes in mice by 3K3A-activated protein C	122
Early innate role for CD8αα+ cells in tuberculosis	115
Primary tumor–derived systemic nANGPTL4 inhibits metastasis	111
RORγt eTACs mediate oral tolerance and Treg induction	108
High burden of viruses and bacterial pathobionts drives heightened nasal innate immunity in children	104
ALK2/3 recruitment to the immunological synapse is required for T cell activation and death	98
IL-21 shapes germinal center polarization via light zone B cell selection and cyclin D3 upregulation	95
The pathogenic role of retinoid nuclear receptor signaling in cancer and metabolic syndromes	92
Prenatally derived macrophages support choroidal health and decline in age-related macular degeneration	90
Antibody feedback contributes to facilitating the development of Omicron-reactive memory B cells in SARS-CoV-2 mRNA vaccinees	87
Antigen-independent, autonomous B cell receptor signaling drives activated B cell DLBCL	87
Host factor TIMP1 sustains long-lasting myeloid-biased hematopoiesis after severe infection	86
B cell receptor ligation induces IgE plasma cell elimination	85
Neutralizing antibodies protect mice against Venezuelan equine encephalitis virus aerosol challenge	81
Differential IL-12 signaling induces human natural killer cell activating receptor-mediated ligand-specific expansion	80
Sphingosine 1-phosphate receptor 5 (S1PR5) regulates the peripheral retention of tissue-resident lymphocytes	79
TCR signal strength defines distinct mechanisms of T cell dysfunction and cancer evasion	77
A high OXPHOS CD8 T cell subset is predictive of immunotherapy resistance in melanoma patients	77
Posttranscriptional regulation of ILC2 homeostatic function via tristetraprolin	76

Non-professional efferocytosis of Salmonella-infected intestinal epithelial cells in the neonatal host	72
Transit-amplifying cells control R-spondins in the mouse crypt to modulate intestinal stem cell proliferation	72
Hypoxia induces adrenomedullin from lung epithelia, stimulating ILC2 inflammation and immunity	70
Dual role of vascular endothelial growth factor-C in post-stroke recovery	69
Systems-level conservation of the proximal TCR signaling network of mice and humans	69
Making memories with Bcl-6	67
pDCs, type 1 IFN, and the female predileXion of SSc	65
Challenges in TB research	65
CD8+ T cell depletion prevents neuropathology in a mouse model of globoid cell leukodystrophy	64
Lymphatic chain gradients regulate the magnitude and heterogeneity of T cell responses to vaccination	64
Implication of folate deficiency in CYP2U1 loss of function	64
IFNγ score–based neoadjuvant immunotherapy for stage III melanoma	64
Loss of ATG7 in microglia impairs UPR, triggers ferroptosis, and weakens amyloid pathology control	64
Correction: Segmented filamentous bacteria–induced epithelial MHCII regulates cognate CD4+ IELs and epithelial turnover	63
Obesity alters monocyte developmental trajectories to enhance metastasis	63
Correction: ICAM-1 controls development and function of ILC2	63
NFAT5 governs cellular plasticity-driven resistance to KRAS-targeted therapy in pancreatic cancer	62
CXCL12+ dermal fibroblasts promote neutrophil recruitment and host defense by recognition of IL-17	62
The genetic background shapes the susceptibility to mitochondrial dysfunction and NASH progression	61
Role of adipose tissue macrophages in obesity-related disorders	61
TIGIT mediates activation-induced cell death of ILC2s during chronic airway allergy	61
A human STAT3 gain-of-function variant drives local Th17 dysregulation and skin inflammation in mice	60
Michelle Linterman: We are always learning	59
CD150-dependent hematopoietic stem cell sensing of Brucella instructs myeloid commitment	58
Augmenting neurogenesis rescues memory impairments in Alzheimer’s disease by restoring the memory-storing neurons	57
Tingible body macrophages: Gargantuan chameleons of the germinal center	57
Somatic gain-of-function mutations in BUD13 promote oncogenesis by disrupting Fbw7 function	57
Nina Cabezas Wallscheid: Enjoying the freedom to decide my research path	56
How decreasing T cell signaling unexpectedly results in autoimmunity	56
Functional specialization of short-lived and long-lived macrophage subsets in human tonsils	56
MYO1F in neutrophils is required for the response to immune checkpoint blockade therapy	56
A twist in the tail: Of T cell subsets and disease	55
Targeting infection-specific peptides in immunopeptidomics studies for vaccine target discovery	55
Human autoantibodies underlying infectious diseases	54
Inherited human ITK deficiency impairs IFN-γ immunity and underlies tuberculosis	54
CXCR4+ Treg cells control serum IgM levels and natural IgM autoantibody production by B-1 cells in the bone marrow	54
Pleiotrophin drives a prometastatic immune niche in breast cancer	54
Amino acid availability acts as a metabolic rheostat to determine the magnitude of ILC2 responses	54
Dietary intervention preserves β cell function in mice through CTCF-mediated transcriptional reprogramming	53
Immunomolecular and reactivity landscapes of gut IgA subclasses in homeostasis and inflammatory bowel disease	53
Protective fibroblastic niches in secondary lymphoid organs	53
IEC-intrinsic IL-1R signaling holds dual roles in regulating intestinal homeostasis and inflammation	53
MYC is a clinically significant driver of mTOR inhibitor resistance in breast cancer	52
TIMP1 expression underlies sex disparity in liver metastasis and survival in pancreatic cancer	51
Memory B cell responses to Omicron subvariants after SARS-CoV-2 mRNA breakthrough infection in humans	51
Promiscuous recognition of MR1 drives self-reactive mucosal-associated invariant T cell responses	51
Gut epithelial IL-27 confers intestinal immunity through the induction of intraepithelial lymphocytes	50
Altered glycosylation in pancreatic cancer and beyond	50
Deficiency for SAMHD1 activates MDA5 in a cGAS/STING-dependent manner	50
Spatiotemporal dynamics of fetal liver hematopoietic niches	49

Protein arginine methyltransferase 1 regulates B cell fate after positive selection in the germinal center in mice	48
Correction: Chromatin landscapes reveal developmentally encoded transcriptional states that define human glioblastoma	48
Tumor-derived OBP2A promotes prostate cancer castration resistance	48
Ki67 deficiency impedes chromatin accessibility and BCR gene rearrangement	47
Correction: Role of affinity in plasma cell development in the germinal center light zone	47
Immature B cell homing shapes human lymphoid tissue structure and function	47
Sara Suliman: Science is better when it’s shared	47
Changing behind the scenes	46
Correction: Mouse model of SARS-CoV-2 reveals inflammatory role of type I interferon signaling	46
Hnf4 activates mimetic-cell enhancers to recapitulate gut and liver development within the thymus	46
CTLA4 prohibits T cells from cross-dressing	45
Targeting neuroinflammation in neuropathic pain and opioid use	45
Differential impact of lymphatic outflow pathways on cerebrospinal fluid homeostasis	44
CD4+ T cell dysfunction in cancer	44
Altered X-chromosome inactivation of the TLR7/8 locus and heterogeneity of pDCs in systemic sclerosis	44
TET2–STAT3–CXCL5 nexus promotes neutrophil lipid transfer to fuel lung adeno-to-squamous transition	44
Regulatory T cells converted from Th1 cells in tumors suppress cancer immunity via CD39	44
TCR signaling induces STAT3 phosphorylation to promote TH17 cell differentiation	44
The common HAQ STING allele prevents clinical penetrance of COPA syndrome	44
Gain-of-function human UNC93B1 variants cause systemic lupus erythematosus and chilblain lupus	43
Correction: SCFβ-TRCP suppresses angiogenesis and thyroid cancer cell migration by promoting ubiquitination and destruction of VEGF receptor 2	43
Transient astrocytic mGluR5 expression drives synaptic plasticity and subsequent chronic pain in mice	43
NK cell expansion requires HuR and mediates control of solid tumors and long-term virus infection	43
Macrophages in the synovial lining niche initiate neutrophil recruitment and articular inflammation	42
Activating NO–sGC crosstalk in the mouse vascular niche promotes vascular integrity and mitigates acute lung injury	42
Functional vulnerability of liver macrophages to capsules defines virulence of blood-borne bacteria	42
Synaptic pruning of murine adult-born neurons by microglia depends on phosphatidylserine	42
DNA damage contributes to neurotoxic inflammation in Aicardi-Goutières syndrome astrocytes	41
Women in STEM becoming independent: The journey to independence is an immensely gratifying odyssey	41
CAR-T cell manufacturing: Major process parameters and next-generation strategies	41
Laura Mackay: Don't be afraid to engage	41
Correction: Profiling HPV-16–specific T cell responses reveals broad antigen reactivities in oropharyngeal cancer patients	41
Perfecting antigen prediction	40
Loss of ARID3A perturbs intestinal epithelial proliferation–differentiation ratio and regeneration	40
Dominant negative OTULIN-related autoinflammatory syndrome	40
Correction: Context-dependent effects of IL-2 rewire immunity into distinct cellular circuits	40
Addendum: Resolvins suppress tumor growth and enhance cancer therapy	40
Age- and diet-instructed metabolic rewiring of the tumor–immune microenvironment	40
Correction: Antigen-presenting autoreactive B cells activate regulatory T cells and suppress autoimmune arthritis in mice	40
Coxsackievirus A10 impairs nail regeneration and induces onychomadesis by mimicking DKK1 to attenuate Wnt signaling	40
A cell-free antigen processing system informs HIV-1 epitope selection and vaccine design	39
Correction: Precursor central memory versus effector cell fate and naïve CD4+ T cell heterogeneity	39
A path forward for Staphylococcus aureus vaccine development	38
Neonatal microbiota colonization primes maturation of goblet cell–mediated protection in the pre-weaning colon	38
Dynamic Foxp3–chromatin interaction controls tunable Treg cell function	38
Trapping of CDC42 C-terminal variants in the Golgi drives pyrin inflammasome hyperactivation	37
Succinate-producing microbiota drives tuft cell hyperplasia to protect against Clostridioides difficile	37
CD163+ macrophages monitor enhanced permeability at the blood–dorsal root ganglion barrier	37
Chronic activation of pDCs in autoimmunity is linked to dysregulated ER stress and metabolic responses	37
Hemifacial myohyperplasia is due to somatic muscular PIK3CA gain-of-function mutations and responds to pharmacological inhibition	37
Vision rescue via unconstrained in vivo prime editing in degenerating neural retinas	36
Disruption of thymic central tolerance by infection with murine roseolovirus induces autoimmune gastritis	36
Identification of conserved SARS-CoV-2 spike epitopes that expand public cTfh clonotypes in mild COVID-19 patients	36
Intestinal epithelial tuft cell induction is negated by a murine helminth and its secreted products	35
Competitive fungal commensalism mitigates candidiasis pathology	35
Cigarette smoke components modulate the MR1–MAIT axis	35
Intravital imaging of pulmonary lymphatics in inflammation and metastatic cancer	35
Distinct fibroblast progenitor subpopulation expedites regenerative mucosal healing by immunomodulation	35
Membrane-IL12 adjuvant mRNA vaccine polarizes pre-effector T cells for optimized tumor control	34
HMCN1 variants aggravate epidermolysis bullosa simplex phenotype	34
Individuals with JAK1 variants are affected by syndromic features encompassing autoimmunity, atopy, colitis, and dermatitis	34
Lysophosphatidylserines derived from microbiota in Crohn’s disease elicit pathological Th1 response	34
Charting the meningeal lymphatic network	34
Repurposing a tricyclic antidepressant in tumor and metabolism disease treatment through fatty acid uptake inhibition	34
Iron TAMs: The fallen protectors	33
Immunologic signatures of response and resistance to nivolumab with ipilimumab in advanced metastatic cancer	33
Rare SH2B3 coding variants in lupus patients impair B cell tolerance and predispose to autoimmunity	33
Megakaryopoiesis impairment through acute innate immune signaling activation by azacitidine	33
Trav15-dv6 family Tcrd rearrangements diversify the Tcra repertoire	33
A TLR7 antagonist restricts interferon-dependent and -independent immunopathology in a mouse model of severe influenza	32
Stalled but not forgotten: Bacterial exotoxins inhibit translation to activate NLRP1	32
RAC2 gain-of-function variants causing inborn error of immunity drive NLRP3 inflammasome activation	32
Nucleotide modifications enable rational design of TLR7-selective ligands by blocking RNase cleavage	32
Inhibitory pattern recognition receptors	31
VEGF-C prophylaxis favors lymphatic drainage and modulates neuroinflammation in a stroke model	31
Tumor-instructed glutamine synthesis in cancer-associated fibroblasts promotes pro-tumor macrophages	31
CD4+ T helper 2 cells suppress breast cancer by inducing terminal differentiation	31
The PML hub: An emerging actor of leukemia therapies	30
Urine scRNAseq reveals new insights into the bladder tumor immune microenvironment	30
Inborn errors of TLR3- or MDA5-dependent type I IFN immunity in children with enterovirus rhombencephalitis	30

Recessive inborn errors of type I IFN immunity in children with COVID-19 pneumonia	30
No added sugar: CCDC134 stabilizes ER chaperone Gp96 for TLR biogenesis	29
Correction: Mapping and role of T cell response in SARS-CoV-2–infected mice	29
Correction: TRAF3–EWSR1 signaling axis acts as a checkpoint on germinal center responses	29
Th17-to-Tfh plasticity during periodontitis limits disease pathology	29
Activated PI3Kδ signals compromise plasma cell survival via limiting autophagy and increasing ER stress	29
Role of PRC2 in the stochastic expression of Aire target genes and development of mimetic cells in the thymus	29
Enhanced IL-2 in early life limits the development of TFH and protective antiviral immunity	29
Use of 3M-052-AF with Alum adjuvant in HIV trimer vaccine induces human autologous neutralizing antibodies	29
Fueling the fire in the gut	29
Macro-clusters: CD301b+ DCs prime Th2 responses	29
Lymph node fibroblastic reticular cells regulate differentiation and function of CD4 T cells via CD25	29
Microbiota and adipocyte mitochondrial damage in type 2 diabetes are linked by Mmp12+ macrophages	28
Distinct molecular profiles drive multifaceted characteristics of colorectal cancer metastatic seeds	28
Tumor-associated neutrophils attenuate the immunosensitivity of hepatocellular carcinoma	28
Eating away T cell responses in lung cancer	28
Intercrypt sentinel macrophages tune antibacterial NF-κB responses in gut epithelial cells via TNF	27
Human CARMIL2 deficiency underlies a broader immunological and clinical phenotype than CD28 deficiency	27
STAT3 gain of function: Too much of a good thing in the skin!	27
Gut dysbiosis from high-salt diet promotes glioma via propionate-mediated TGF-β activation	27
Pathogenic autoantibodies to IFN-γ act through the impedance of receptor assembly and Fc-mediated response	27
Glucosamine amends CNS pathology in mucopolysaccharidosis IIIC mouse expressing misfolded HGSNAT	27
Clonal lineage tracing reveals mechanisms skewing CD8+ T cell fate decisions in chronic infection	27
Delineating a serotonin 1B receptor circuit for appetite suppression in mice	26
Recurrent infection transiently expands human tissue T cells while maintaining long-term homeostasis	26
PARP7 inhibits type I interferon signaling to prevent autoimmunity and lung disease	26
Linda-Gail Bekker: Mentorship is critical for anyone in STEM	26
Identifying genetic errors of immunity due to mosaicism	26
S1PR1 regulates lymphatic valve development and tertiary lymphoid organ formation in the ileum	26
Emerging in vivo tools for ILC2 research	26
Modeling memory B cell responses in a lymphoid organ-chip to evaluate mRNA vaccine boosting	26
Stopping the fat: Repurposing an antidepressant for cancer treatment	26
The stunning clodronate	26
KLF2 expression in IgG plasma cells at their induction site regulates the migration program	26
Expression of Concern: ΔNp73, A Dominant-Negative Inhibitor of Wild-type p53 and TAp73, Is Up-regulated in Human Tumors	25
Mechanosensing regulates pDC activation in the skin through NRF2 activation	25
Intravenous administration of BCG protects mice against lethal SARS-CoV-2 challenge	25
Act1 drives chemoresistance via regulation of antioxidant RNA metabolism and redox homeostasis	25
The X factor in neurodegeneration	25
Lymph node metastasis: An immunological burden	25
IL-17A–producing γδT cells promote muscle regeneration in a microbiota-dependent manner	25
Landscape of mast cell populations across organs in mice and humans	25
GIMAP6 regulates autophagy, immune competence, and inflammation in mice and humans	24
Single-cell transcriptomic analysis of human colonic macrophages reveals niche-specific subsets	24
OTULIN and Muller’s morphs	24
Correction: Single-cell analysis of the cellular heterogeneity and interactions in the injured mouse spinal cord	24
Baseline colitogenicity and acute perturbations of gut microbiota in immunotherapy-related colitis	24
Guardians of the oral barriers	24
NADPH oxidase exerts a B cell–intrinsic contribution to lupus risk by modulating endosomal TLR signals	24
LYVE1+ macrophages of murine peritoneal mesothelium promote omentum-independent ovarian tumor growth	24
Immunopathological and microbial signatures of inflammatory bowel disease in partial RAG deficiency	24
A TNF-IL-1 circuit controls Yersinia within intestinal pyogranulomas	24
Filamin A editing in myeloid cells reduces intestinal inflammation and protects from colitis	23
Lymphatic transport in anti-tumor immunity and metastasis	23
Tumor cell–intrinsic Piezo2 drives radioresistance by impairing CD8+ T cell stemness maintenance	23
Repertoire, function, and structure of serological antibodies induced by the R21/Matrix-M malaria vaccine	23
OX40L-expressing recombinant modified vaccinia virus Ankara induces potent antitumor immunity via reprogramming Tregs	23
Mitochondrial pyruvate metabolism and glutaminolysis toggle steady-state and emergency myelopoiesis	23
A viral E3 ubiquitin ligase produced by herpes simplex virus 1 inhibits the NLRP1 inflammasome	23
Stability and heterogeneity in the antimicrobiota reactivity of human milk-derived immunoglobulin A	23
Periductal fibroblasts participate in liver homeostasis, fibrosis, and tumorigenesis	23
Mutations disrupting the kinase domain of IKKα lead to immunodeficiency and immune dysregulation in humans	23
In vivo antibody diversification targeting a conserved coronavirus epitope	23