Journal of Experimental Medicine

Article	Citations
Early innate role for CD8αα+ cells in tuberculosis	252
S1PR1, an endothelial-immune influencer	166
Primary tumor–derived systemic nANGPTL4 inhibits metastasis	155
Intestinal epithelial c-Maf expression determines enterocyte differentiation and nutrient uptake in mice	137
SARS-CoV-2 Spike protein suppresses CTL-mediated killing by inhibiting immune synapse assembly	132
Antigen-independent, autonomous B cell receptor signaling drives activated B cell DLBCL	119
IL-21 shapes germinal center polarization via light zone B cell selection and cyclin D3 upregulation	116
High burden of viruses and bacterial pathobionts drives heightened nasal innate immunity in children	115
Prenatally derived macrophages support choroidal health and decline in age-related macular degeneration	113
An iron-rich subset of macrophages promotes tumor growth through a Bach1-Ednrb axis	113
Leveraging cDC1 biology and function for enhanced immunotherapy	112
ALK2/3 recruitment to the immunological synapse is required for T cell activation and death	110
Epitope and HLA specificity of human TCRs against Plasmodium falciparum circumsporozoite protein	103
Common cold embecovirus imprinting primes broadly neutralizing antibody responses to SARS-CoV-2 S2	101
Host factor TIMP1 sustains long-lasting myeloid-biased hematopoiesis after severe infection	99
RORγt eTACs mediate oral tolerance and Treg induction	97
The pathogenic role of retinoid nuclear receptor signaling in cancer and metabolic syndromes	95
Inhibition of astrocytic DRD2 suppresses CNS inflammation in an animal model of multiple sclerosis	93
Local gene editing of fibroblasts in tumors reveals a new cancer-associated fibroblast state	93
B cell receptor ligation induces IgE plasma cell elimination	90
Obesity alters monocyte developmental trajectories to enhance metastasis	89
IFNγ score–based neoadjuvant immunotherapy for stage III melanoma	89
Antibody feedback contributes to facilitating the development of Omicron-reactive memory B cells in SARS-CoV-2 mRNA vaccinees	89
pDCs, type 1 IFN, and the female predileXion of SSc	87
Transit-amplifying cells control R-spondins in the mouse crypt to modulate intestinal stem cell proliferation	87

Non-professional efferocytosis of Salmonella-infected intestinal epithelial cells in the neonatal host	86
CD8+ T cell depletion prevents neuropathology in a mouse model of globoid cell leukodystrophy	86
Correction: ICAM-1 controls development and function of ILC2	84
Correction: Segmented filamentous bacteria–induced epithelial MHCII regulates cognate CD4+ IELs and epithelial turnover	82
The genetic background shapes the susceptibility to mitochondrial dysfunction and NASH progression	80
Lymphatic chain gradients regulate the magnitude and heterogeneity of T cell responses to vaccination	79
Challenges in TB research	78
NFAT5 governs cellular plasticity-driven resistance to KRAS-targeted therapy in pancreatic cancer	77
Loss of ATG7 in microglia impairs UPR, triggers ferroptosis, and weakens amyloid pathology control	76
Heterozygous human JAK2V617F activates AhR to drive essential thrombocythemia and promote thrombosis	75
Dual role of vascular endothelial growth factor-C in post-stroke recovery	73
CXCL12+ dermal fibroblasts promote neutrophil recruitment and host defense by recognition of IL-17	73
T cell engagers emerge as a compelling therapeutic modality	69
TIGIT mediates activation-induced cell death of ILC2s during chronic airway allergy	69
A human STAT3 gain-of-function variant drives local Th17 dysregulation and skin inflammation in mice	69
How decreasing T cell signaling unexpectedly results in autoimmunity	69
Michelle Linterman: We are always learning	68
Nina Cabezas Wallscheid: Enjoying the freedom to decide my research path	66
Tingible body macrophages: Gargantuan chameleons of the germinal center	65
A twist in the tail: Of T cell subsets and disease	65
IEC-intrinsic IL-1R signaling holds dual roles in regulating intestinal homeostasis and inflammation	62
Protein arginine methyltransferase 1 regulates B cell fate after positive selection in the germinal center in mice	60
Functional specialization of short-lived and long-lived macrophage subsets in human tonsils	60
Somatic gain-of-function mutations in BUD13 promote oncogenesis by disrupting Fbw7 function	59
Inherited human ITK deficiency impairs IFN-γ immunity and underlies tuberculosis	58
CD150-dependent hematopoietic stem cell sensing of Brucella instructs myeloid commitment	57
Protective fibroblastic niches in secondary lymphoid organs	57
Pleiotrophin drives a prometastatic immune niche in breast cancer	57
MYC is a clinically significant driver of mTOR inhibitor resistance in breast cancer	56
Memory B cell responses to Omicron subvariants after SARS-CoV-2 mRNA breakthrough infection in humans	56
Targeting infection-specific peptides in immunopeptidomics studies for vaccine target discovery	56
PRECISE-seq reveals disease-relevant TCR repertoires with phenotypic plasticity	55
Oral antigen exposure under costimulation blockade induces Treg cells to establish immune tolerance	54
Spatiotemporal dynamics of fetal liver hematopoietic niches	54
Rethinking disomy: Autosomal expression bias	53
Augmenting neurogenesis rescues memory impairments in Alzheimer’s disease by restoring the memory-storing neurons	52
Deficiency for SAMHD1 activates MDA5 in a cGAS/STING-dependent manner	52
Amino acid availability acts as a metabolic rheostat to determine the magnitude of ILC2 responses	52
MYO1F in neutrophils is required for the response to immune checkpoint blockade therapy	51
Promiscuous recognition of MR1 drives self-reactive mucosal-associated invariant T cell responses	51
eIF3e-mediated translational checkpoint maintains immune tolerance and prevents lymphoid malignancy	51
Immunomolecular and reactivity landscapes of gut IgA subclasses in homeostasis and inflammatory bowel disease	50
Sara Suliman: Science is better when it’s shared	50
CTLA4 prohibits T cells from cross-dressing	49
Correction: SCFβ-TRCP suppresses angiogenesis and thyroid cancer cell migration by promoting ubiquitination and destruction of VEGF receptor 2	48
Changing behind the scenes	48
Correction: Chromatin landscapes reveal developmentally encoded transcriptional states that define human glioblastoma	47
Ki67 deficiency impedes chromatin accessibility and BCR gene rearrangement	46
Correction: Mouse model of SARS-CoV-2 reveals inflammatory role of type I interferon signaling	46
Correction: REV-ERB regulates RORγt+ regulatory T cell specification and function through the Bhlhe40-c-Maf axis	46

Immature B cell homing shapes human lymphoid tissue structure and function	45
Correction: B cell tolerance and antibody production to the celiac disease autoantigen transglutaminase 2	45
TET2–STAT3–CXCL5 nexus promotes neutrophil lipid transfer to fuel lung adeno-to-squamous transition	45
Correction: Role of affinity in plasma cell development in the germinal center light zone	44
Targeting neuroinflammation in neuropathic pain and opioid use	44
Activating NO–sGC crosstalk in the mouse vascular niche promotes vascular integrity and mitigates acute lung injury	44
NK cell expansion requires HuR and mediates control of solid tumors and long-term virus infection	44
Macrophages in the synovial lining niche initiate neutrophil recruitment and articular inflammation	44
Gain-of-function human UNC93B1 variants cause systemic lupus erythematosus and chilblain lupus	43
Chimeric MHC class I– and II–restricted non-self epitopes broaden antitumor T cell reactions	42
CD4+ T cell dysfunction in cancer	42
Tumor-derived OBP2A promotes prostate cancer castration resistance	42
Epigenetic and metabolic reprogramming support plasma cell differentiation in germinal centers	42
TCR signaling induces STAT3 phosphorylation to promote TH17 cell differentiation	41
Altered X-chromosome inactivation of the TLR7/8 locus and heterogeneity of pDCs in systemic sclerosis	40
Hnf4 activates mimetic-cell enhancers to recapitulate gut and liver development within the thymus	40
IgD from atypical-like memory B cells and plasma cells targets commensal and environmental antigens	40
Regulatory T cells converted from Th1 cells in tumors suppress cancer immunity via CD39	40
Perfecting antigen prediction	39
Laura Mackay: Don't be afraid to engage	39
Differential impact of lymphatic outflow pathways on cerebrospinal fluid homeostasis	39
CAR-T cell manufacturing: Major process parameters and next-generation strategies	39
The common HAQ STING allele prevents clinical penetrance of COPA syndrome	39
Women in STEM becoming independent: The journey to independence is an immensely gratifying odyssey	39
Addendum: Resolvins suppress tumor growth and enhance cancer therapy	38
Correction: Profiling HPV-16–specific T cell responses reveals broad antigen reactivities in oropharyngeal cancer patients	38
Correction: Antigen-presenting autoreactive B cells activate regulatory T cells and suppress autoimmune arthritis in mice	38
Correction: Context-dependent effects of IL-2 rewire immunity into distinct cellular circuits	38
A cell-free antigen processing system informs HIV-1 epitope selection and vaccine design	37
A path forward for Staphylococcus aureus vaccine development	37
Correction: Precursor central memory versus effector cell fate and naïve CD4+ T cell heterogeneity	37
Staying IgD positive in a challenging environment	37
Vision rescue via unconstrained in vivo prime editing in degenerating neural retinas	37
Loss of ARID3A perturbs intestinal epithelial proliferation–differentiation ratio and regeneration	37
Succinate-producing microbiota drives tuft cell hyperplasia to protect against Clostridioides difficile	36
Neonatal microbiota colonization primes maturation of goblet cell–mediated protection in the pre-weaning colon	36
Cigarette smoke components modulate the MR1–MAIT axis	36
MHC one–two punch knocks out cancer	36
CSF1R-dependent CD169-positive macrophages locally constrain melanoma growth in the skin	36
Liver-X-receptor agonism enhances T cell priming and activation to promote anti-tumor immunity	36
Competitive fungal commensalism mitigates candidiasis pathology	35
Hemifacial myohyperplasia is due to somatic muscular PIK3CA gain-of-function mutations and responds to pharmacological inhibition	35
Intravital imaging of pulmonary lymphatics in inflammation and metastatic cancer	35
Chronic activation of pDCs in autoimmunity is linked to dysregulated ER stress and metabolic responses	35
Coxsackievirus A10 impairs nail regeneration and induces onychomadesis by mimicking DKK1 to attenuate Wnt signaling	35
Age- and diet-instructed metabolic rewiring of the tumor–immune microenvironment	34
Distinct fibroblast progenitor subpopulation expedites regenerative mucosal healing by immunomodulation	34
CD163+ macrophages monitor enhanced permeability at the blood–dorsal root ganglion barrier	34
IFNγ-induced memory in human macrophages is sustained by the durability of cytokine signaling itself	34
Dominant negative OTULIN-related autoinflammatory syndrome	34
Charting the meningeal lymphatic network	33
Dynamic Foxp3–chromatin interaction controls tunable Treg cell function	33
Iron TAMs: The fallen protectors	33
Stalled but not forgotten: Bacterial exotoxins inhibit translation to activate NLRP1	33
Individuals with JAK1 variants are affected by syndromic features encompassing autoimmunity, atopy, colitis, and dermatitis	32
RAC2 gain-of-function variants causing inborn error of immunity drive NLRP3 inflammasome activation	32
Megakaryopoiesis impairment through acute innate immune signaling activation by azacitidine	32
HMCN1 variants aggravate epidermolysis bullosa simplex phenotype	32
Nucleotide modifications enable rational design of TLR7-selective ligands by blocking RNase cleavage	32
Repurposing a tricyclic antidepressant in tumor and metabolism disease treatment through fatty acid uptake inhibition	32
RIPK1 S161 phosphorylation promotes further autophosphorylation and cecal necroptosis in TNF-treated mice	32
Immunologic signatures of response and resistance to nivolumab with ipilimumab in advanced metastatic cancer	31
Urine scRNAseq reveals new insights into the bladder tumor immune microenvironment	31
In vivo CRISPR/Cas9 screens identify new regulators of B cell activation and plasma cell differentiation	31
Rare SH2B3 coding variants in lupus patients impair B cell tolerance and predispose to autoimmunity	31
Tumor-instructed glutamine synthesis in cancer-associated fibroblasts promotes pro-tumor macrophages	30
Pathogenic autoantibodies to IFN-γ act through the impedance of receptor assembly and Fc-mediated response	30
Distinct molecular profiles drive multifaceted characteristics of colorectal cancer metastatic seeds	30
Eating away T cell responses in lung cancer	30
VEGF-C prophylaxis favors lymphatic drainage and modulates neuroinflammation in a stroke model	30
Th17-to-Tfh plasticity during periodontitis limits disease pathology	30
Macro-clusters: CD301b+ DCs prime Th2 responses	30
Membrane-IL12 adjuvant mRNA vaccine polarizes pre-effector T cells for optimized tumor control	30
Correction: TRAF3–EWSR1 signaling axis acts as a checkpoint on germinal center responses	30
The PML hub: An emerging actor of leukemia therapies	30
Bidirectional regulation by BACH2 coordinates systemic CXCR5− vs. CXCR5+ CD4+ T cell differentiation	30
Targeting UBE2F induces a resilience program enhancing CD8 T cell immunity	29
Human CARMIL2 deficiency underlies a broader immunological and clinical phenotype than CD28 deficiency	29
Tumor-associated neutrophils attenuate the immunosensitivity of hepatocellular carcinoma	29
Use of 3M-052-AF with Alum adjuvant in HIV trimer vaccine induces human autologous neutralizing antibodies	29

No added sugar: CCDC134 stabilizes ER chaperone Gp96 for TLR biogenesis	29
Does fever drive the evolution of antiviral genes?	28
Clonal lineage tracing reveals mechanisms skewing CD8+ T cell fate decisions in chronic infection	28
B7 costimulation antagonizes RORγt+ regulatory T cells and immune tolerance in the intestine	28
Gut dysbiosis from high-salt diet promotes glioma via propionate-mediated TGF-β activation	28
Splenic cDC1 efferocytosis and cross-presentation to CD8 T cells are promoted by GPR34 and lysophosphatidylserine	28
Role of PRC2 in the stochastic expression of Aire target genes and development of mimetic cells in the thymus	28
Recurrent infection transiently expands human tissue T cells while maintaining long-term homeostasis	27
Expression of Concern: ΔNp73, A Dominant-Negative Inhibitor of Wild-type p53 and TAp73, Is Up-regulated in Human Tumors	27
Stopping the fat: Repurposing an antidepressant for cancer treatment	27
Linda-Gail Bekker: Mentorship is critical for anyone in STEM	27
Lymph node metastasis: An immunological burden	27
STAT3 gain of function: Too much of a good thing in the skin!	27
Delineating a serotonin 1B receptor circuit for appetite suppression in mice	27
The stunning clodronate	26
XPR1 regulates fetal liver macrophage development, identity, and pyrenocyte clearance	26
Identifying genetic errors of immunity due to mosaicism	26
Baseline colitogenicity and acute perturbations of gut microbiota in immunotherapy-related colitis	26
Heterologous mucosal vaccine boosting enhances mucosal and systemic immunity by distinct mechanisms	26
The X factor in neurodegeneration	26
Emerging in vivo tools for ILC2 research	26
A PI3Kδ-Foxo1-FasL signaling amplification loop rewires CD4+ T cell signaling and differentiation	26
PARP7 inhibits type I interferon signaling to prevent autoimmunity and lung disease	26
Act1 drives chemoresistance via regulation of antioxidant RNA metabolism and redox homeostasis	26
Mechanosensing regulates pDC activation in the skin through NRF2 activation	26
KLF2 expression in IgG plasma cells at their induction site regulates the migration program	26
Guardians of the oral barriers	25
An engineered concealed IL-15-R elicits tumor-specific CD8+T cell responses through PD-1-cis delivery	25
S1PR1 regulates lymphatic valve development and tertiary lymphoid organ formation in the ileum	25
Modeling memory B cell responses in a lymphoid organ-chip to evaluate mRNA vaccine boosting	25
Immunopathological and microbial signatures of inflammatory bowel disease in partial RAG deficiency	25
Landscape of mast cell populations across organs in mice and humans	25
Correction: Hepatic IRE1α-XBP1 signaling promotes GDF15-mediated anorexia and body weight loss in chemotherapy	25
Correction: Single-cell analysis of the cellular heterogeneity and interactions in the injured mouse spinal cord	25
Myeloid diversity in tumors: Shaped by genes, location, and time	25
BATF represses BIM to sustain tolerant T cells in the periphery	24
OTULIN and Muller’s morphs	24
OX40L-expressing recombinant modified vaccinia virus Ankara induces potent antitumor immunity via reprogramming Tregs	24
A “multi-omics” analysis of blood–brain barrier and synaptic dysfunction in APOE4 mice	24
NADPH oxidase exerts a B cell–intrinsic contribution to lupus risk by modulating endosomal TLR signals	24
Periductal fibroblasts participate in liver homeostasis, fibrosis, and tumorigenesis	24
Tumor cell–intrinsic Piezo2 drives radioresistance by impairing CD8+ T cell stemness maintenance	24
Mitochondrial pyruvate metabolism and glutaminolysis toggle steady-state and emergency myelopoiesis	23
Retraction: Tumors with TSC mutations are sensitive to CDK7 inhibition through NRF2 and glutathione depletion	23
Filamin A editing in myeloid cells reduces intestinal inflammation and protects from colitis	23
A half-century of research on tuberculosis: Successes and challenges	23
Mutations disrupting the kinase domain of IKKα lead to immunodeficiency and immune dysregulation in humans	23
A viral E3 ubiquitin ligase produced by herpes simplex virus 1 inhibits the NLRP1 inflammasome	23
Next-generation CRISPR screens enable causal systems immunology	23
A TNF-IL-1 circuit controls Yersinia within intestinal pyogranulomas	23
PD-1 and TIM-3 differentially regulate subsets of mouse IL-17A–producing γδ T cells	23
Repertoire, function, and structure of serological antibodies induced by the R21/Matrix-M malaria vaccine	23
Perturbation of calreticulin potentiates CD8+ T cell–mediated antitumor immunity	22
Five decades of natural killer cell discovery	22
Stability and heterogeneity in the antimicrobiota reactivity of human milk-derived immunoglobulin A	22
Trained immunity of alveolar macrophages enhances injury resolution via KLF4-MERTK-mediated efferocytosis	22
Kids’ noses resist COVID-19	22
In vivo antibody diversification targeting a conserved coronavirus epitope	22
Transfer of nuclear and ribosomal material from Sox10-lineage cells to neurons in the mouse brain	22
Lymphatic transport in anti-tumor immunity and metastasis	22