Journal of Experimental Medicine

(The TQCC of Journal of Experimental Medicine is 64. The table below lists those papers that are above that threshold based on CrossRef citation counts. The publications cover those that have been published in the past four years, i.e., from 2019-03-01 to 2023-03-01.)
Distinct populations of inflammatory fibroblasts and myofibroblasts in pancreatic cancer1157
Inflammasomes are activated in response to SARS-CoV-2 infection and are associated with COVID-19 severity in patients396
The gut microbiome: Relationships with disease and opportunities for therapy375
Resting Respiratory Tract Dendritic Cells Preferentially Stimulate T Helper Cell Type 2 (Th2) Responses and Require Obligatory Cytokine Signals for Induction of  Th1 Immunity359
Type I interferon–mediated monogenic autoinflammation: The type I interferonopathies, a conceptual overview286
Context-dependent EMT programs in cancer metastasis284
Nucleoside-modified mRNA vaccines induce potent T follicular helper and germinal center B cell responses281
Oxidized mitochondrial nucleoids released by neutrophils drive type I interferon production in human lupus276
Widespread transneuronal propagation of α-synucleinopathy triggered in olfactory bulb mimics prodromal Parkinson’s disease266
Development and plasticity of meningeal lymphatic vessels227
Detection of interferon alpha protein reveals differential levels and cellular sources in disease226
Biology and therapeutic potential of interleukin-10206
T-bet negatively regulates autoimmune myocarditis by suppressing local production of interleukin 17202
Neutrophils facilitate ovarian cancer premetastatic niche formation in the omentum195
Microbiome–microglia connections via the gut–brain axis186
IgA regulates the composition and metabolic function of gut microbiota by promoting symbiosis between bacteria177
Microglia drive APOE-dependent neurodegeneration in a tauopathy mouse model173
Androgen signaling negatively controls group 2 innate lymphoid cells168
Ticks produce highly selective chemokine binding proteins with antiinflammatory activity164
Macrophages of distinct origins contribute to tumor development in the lung156
CXCR6 regulates localization of tissue-resident memory CD8 T cells to the airways155
Single-cell transcriptome analysis reveals differential nutrient absorption functions in human intestine152
A major role for ferroptosis in Mycobacterium tuberculosis–induced cell death and tissue necrosis145
Predicting the response to CTLA-4 blockade by longitudinal noninvasive monitoring of CD8 T cells143
COVID-19 and emerging viral infections: The case for interferon lambda143
Inflammasome signaling and regulation of interleukin-1 family cytokines141
NK cells switch from granzyme B to death receptor–mediated cytotoxicity during serial killing137
Commensal microbes provide first line defense against Listeria monocytogenes infection136
Toxoplasma gondii TgIST co-opts host chromatin repressors dampening STAT1-dependent gene regulation and IFN-γ–mediated host defenses134
Gasdermins and their role in immunity and inflammation126
Interferon-induced guanylate-binding proteins: Guardians of host defense in health and disease122
Immune cells and CNS physiology: Microglia and beyond122
Secreted PD-L1 variants mediate resistance to PD-L1 blockade therapy in non–small cell lung cancer122
Life-threatening influenza pneumonitis in a child with inherited IRF9 deficiency122
Preexisting autoantibodies to type I IFNs underlie critical COVID-19 pneumonia in patients with APS-1122
Tissue-resident macrophages in omentum promote metastatic spread of ovarian cancer119
Fyn kinase regulates misfolded α-synuclein uptake and NLRP3 inflammasome activation in microglia118
Loss of the interleukin-6 receptor causes immunodeficiency, atopy, and abnormal inflammatory responses118
CD4+ resident memory T cells dominate immunosurveillance and orchestrate local recall responses116
GM-CSF in inflammation116
STING-mediated disruption of calcium homeostasis chronically activates ER stress and primes T cell death116
Single-cell transcriptomic analysis of tissue-resident memory T cells in human lung cancer115
Sex-specific effects of microbiome perturbations on cerebral Aβ amyloidosis and microglia phenotypes114
Phenotypical and functional alteration of unconventional T cells in severe COVID-19 patients111
Viral entry and escape from antibody-mediated neutralization influence hepatitis C virus reinfection in liver transplantation111
Metronomic chemotherapy prevents therapy-induced stromal activation and induction of tumor-initiating cells110
Innate immune priming in the absence of TAK1 drives RIPK1 kinase activity–independent pyroptosis, apoptosis, necroptosis, and inflammatory disease107
CSF-1 controls cerebellar microglia and is required for motor function and social interaction106
A common transcriptomic program acquired in the thymus defines tissue residency of MAIT and NKT subsets105
Severe influenza pneumonitis in children with inherited TLR3 deficiency104
Intratumoral accumulation of gut microbiota facilitates CD47-based immunotherapy via STING signaling104
Inherited CD70 deficiency in humans reveals a critical role for the CD70–CD27 pathway in immunity to Epstein-Barr virus infection103
Inherited IFNAR1 deficiency in otherwise healthy patients with adverse reaction to measles and yellow fever live vaccines103
Specific targeting of CD163+ TAMs mobilizes inflammatory monocytes and promotes T cell–mediated tumor regression101
Inhibiting antibiotic-resistant Enterobacteriaceae by microbiota-mediated intracellular acidification101
Human dendritic cells (DCs) are derived from distinct circulating precursors that are precommitted to become CD1c+ or CD141+ DCs100
Immune regulation by glucocorticoids can be linked to cell type–dependent transcriptional responses100
Human histocompatibility leukocyte antigen (HLA)-DM edits peptides presented by HLA-DR according to their ligand binding motifs.100
Heterotypic CAF-tumor spheroids promote early peritoneal metastasis of ovarian cancer100
Development of immune checkpoint therapy for cancer99
A noncanonical function of cGAMP in inflammasome priming and activation99
CCL22 controls immunity by promoting regulatory T cell communication with dendritic cells in lymph nodes99
Th1 effector T cells selectively orchestrate cardiac fibrosis in nonischemic heart failure98
Caveolin-1 selectively regulates microRNA sorting into microvesicles after noxious stimuli97
A novel disorder involving dyshematopoiesis, inflammation, and HLH due to aberrant CDC42 function97
Type I interferon induces CXCL13 to support ectopic germinal center formation95
High mobility group box 1 orchestrates tissue regeneration via CXCR494
Mutations in COPA lead to abnormal trafficking of STING to the Golgi and interferon signaling93
SHP2 inhibition diminishes KRASG12C cycling and promotes tumor microenvironment remodeling93
Primary prostate cancer educates bone stroma through exosomal pyruvate kinase M2 to promote bone metastasis91
Auto-antibodies to type I IFNs can underlie adverse reactions to yellow fever live attenuated vaccine91
Ontogeny of human mucosal-associated invariant T cells and related T cell subsets90
Prostate-specific membrane antigen cleavage of vitamin B9 stimulates oncogenic signaling through metabotropic glutamate receptors89
Inflammatory microcrystals differentially regulate the secretion of macrophage inflammatory protein 1 and interleukin 8 by human neutrophils: a possible mechanism of neutrophil recruitment to sites of88
Myeloid-targeted immunotherapies act in synergy to induce inflammation and antitumor immunity87
Gene therapy targeting SARM1 blocks pathological axon degeneration in mice86
Antigen-presenting ILC3 regulate T cell–dependent IgA responses to colonic mucosal bacteria86
Gasdermin D in peripheral myeloid cells drives neuroinflammation in experimental autoimmune encephalomyelitis85
Critical role for Sec22b-dependent antigen cross-presentation in antitumor immunity85
Wnt5a induces and maintains prostate cancer cells dormancy in bone84
Dual T cell– and B cell–intrinsic deficiency in humans with biallelic RLTPR mutations83
High-dimensional single-cell analysis reveals the immune signature of narcolepsy83
Acetate coordinates neutrophil and ILC3 responses against C. difficile through FFAR283
Astrocytes and microglia: Models and tools83
Use of extracellular vesicles from lymphatic drainage as surrogate markers of melanoma progression and BRAFV600E mutation82
A stromal cell niche sustains ILC2-mediated type-2 conditioning in adipose tissue81
SARS-CoV-2 induces human plasmacytoid predendritic cell diversification via UNC93B and IRAK480
The role of interleukin-17 in tumor development and progression80
Unveiling skin macrophage dynamics explains both tattoo persistence and strenuous removal79
LncRNA-encoded polypeptide ASRPS inhibits triple-negative breast cancer angiogenesis79
Modulating inflammation for cancer therapy77
Tumor-associated factors are enriched in lymphatic exudate compared to plasma in metastatic melanoma patients77
Single-cell imaging of CAR T cell activity in vivo reveals extensive functional and anatomical heterogeneity77
ZEB1, ZEB2, and the miR-200 family form a counterregulatory network to regulate CD8+ T cell fates76
KLRG1 and NKp46 discriminate subpopulations of human CD117+CRTH2− ILCs biased toward ILC2 or ILC375
Resident memory CD8 T cells persist for years in human small intestine73
Type III interferons: Balancing tissue tolerance and resistance to pathogen invasion71
Sweetening the hallmarks of cancer: Galectins as multifunctional mediators of tumor progression71
Vasculature-associated fat macrophages readily adapt to inflammatory and metabolic challenges71
Expression of factor V by resident macrophages boosts host defense in the peritoneal cavity70
Contrasting requirements during disease evolution identify EZH2 as a therapeutic target in AML70
SARS-CoV-2–related MIS-C: A key to the viral and genetic causes of Kawasaki disease?70
Toward a better understanding of folate metabolism in health and disease69
Human RELA haploinsufficiency results in autosomal-dominant chronic mucocutaneous ulceration68
ILC2s are the predominant source of intestinal ILC-derived IL-1068
Somatic activating mutations in PIK3CA cause generalized lymphatic anomaly68
Metabolically activated adipose tissue macrophages link obesity to triple-negative breast cancer66
Combination of quadruplex qPCR and next-generation sequencing for qualitative and quantitative analysis of the HIV-1 latent reservoir66
Chromatin landscapes reveal developmentally encoded transcriptional states that define human glioblastoma65
Single-cell analysis of the cellular heterogeneity and interactions in the injured mouse spinal cord64
Impact of naturally forming human α/β-tryptase heterotetramers in the pathogenesis of hereditary α-tryptasemia64
Effects of interleukin-2 in immunostimulation and immunosuppression64