Journal of Experimental Medicine

Papers
(The TQCC of Journal of Experimental Medicine is 27. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-03-01 to 2024-03-01.)
ArticleCitations
Targeting potential drivers of COVID-19: Neutrophil extracellular traps1092
SARS-CoV-2–triggered neutrophil extracellular traps mediate COVID-19 pathology621
Neuroinvasion of SARS-CoV-2 in human and mouse brain579
Inflammasomes are activated in response to SARS-CoV-2 infection and are associated with COVID-19 severity in patients532
Measuring SARS-CoV-2 neutralizing antibody activity using pseudotyped and chimeric viruses460
The many faces of the anti-COVID immune response411
The blood–brain barrier in health and disease: Important unanswered questions354
Lipid metabolism and cancer319
Mouse model of SARS-CoV-2 reveals inflammatory role of type I interferon signaling316
Ferroptosis in infection, inflammation, and immunity287
Neutrophil extracellular traps infiltrate the lung airway, interstitial, and vascular compartments in severe COVID-19264
Antibody potency, effector function, and combinations in protection and therapy for SARS-CoV-2 infection in vivo249
Highly functional virus-specific cellular immune response in asymptomatic SARS-CoV-2 infection246
Blood plasma phosphorylated-tau isoforms track CNS change in Alzheimer’s disease229
Anti-human TREM2 induces microglia proliferation and reduces pathology in an Alzheimer’s disease model213
Interleukin-17–induced neutrophil extracellular traps mediate resistance to checkpoint blockade in pancreatic cancer212
Preexisting autoantibodies to type I IFNs underlie critical COVID-19 pneumonia in patients with APS-1171
COVID-19 and emerging viral infections: The case for interferon lambda166
Intratumoral accumulation of gut microbiota facilitates CD47-based immunotherapy via STING signaling161
PD-1 restraint of regulatory T cell suppressive activity is critical for immune tolerance143
Microglia in Alzheimer's disease at single-cell level. Are there common patterns in humans and mice?140
Phenotypical and functional alteration of unconventional T cells in severe COVID-19 patients140
Accumulation of long-chain fatty acids in the tumor microenvironment drives dysfunction in intrapancreatic CD8+ T cells136
Dynamic innate immune response determines susceptibility to SARS-CoV-2 infection and early replication kinetics134
Mutations in COPA lead to abnormal trafficking of STING to the Golgi and interferon signaling130
SHP2 inhibition diminishes KRASG12C cycling and promotes tumor microenvironment remodeling126
Auto-antibodies to type I IFNs can underlie adverse reactions to yellow fever live attenuated vaccine122
Mapping and role of T cell response in SARS-CoV-2–infected mice119
Single-cell analysis of the cellular heterogeneity and interactions in the injured mouse spinal cord118
Multi-omic profiling reveals widespread dysregulation of innate immunity and hematopoiesis in COVID-19118
Analysis of classical neutrophils and polymorphonuclear myeloid-derived suppressor cells in cancer patients and tumor-bearing mice118
Single-cell analysis of germinal-center B cells informs on lymphoma cell of origin and outcome113
Neutrophil phenotypes and functions in cancer: A consensus statement111
Tumor-infiltrating dendritic cell states are conserved across solid human cancers109
PKM2 promotes Th17 cell differentiation and autoimmune inflammation by fine-tuning STAT3 activation109
A defect in COPI-mediated transport of STING causes immune dysregulation in COPA syndrome107
Inflammation as a regulator of hematopoietic stem cell function in disease, aging, and clonal selection105
Type 1 conventional dendritic cells are systemically dysregulated early in pancreatic carcinogenesis104
Historical overview of the interleukin-6 family cytokine103
Forty years with coronaviruses101
Persistent cellular immunity to SARS-CoV-2 infection100
β-Catenin induces transcriptional expression of PD-L1 to promote glioblastoma immune evasion99
CD36, a signaling receptor and fatty acid transporter that regulates immune cell metabolism and fate97
SARS-CoV-2 induces human plasmacytoid predendritic cell diversification via UNC93B and IRAK497
SARS-CoV-2–related MIS-C: A key to the viral and genetic causes of Kawasaki disease?95
Glutamine depletion regulates Slug to promote EMT and metastasis in pancreatic cancer95
Phenotypic and functional characterization of first-trimester human placental macrophages, Hofbauer cells91
Macrophage morphology correlates with single-cell diversity and prognosis in colorectal liver metastasis90
Activated microglia mitigate Aβ-associated tau seeding and spreading89
The mRNA m6A reader YTHDF2 suppresses proinflammatory pathways and sustains hematopoietic stem cell function89
B cells and cancer: To B or not to B?88
Tissue-resident memory T cells in tumor immunity and immunotherapy88
Tumor-derived IL-6 and trans-signaling among tumor, fat, and muscle mediate pancreatic cancer cachexia86
Microglia modulate blood flow, neurovascular coupling, and hypoperfusion via purinergic actions85
Innate immune pathways and inflammation in hematopoietic aging, clonal hematopoiesis, and MDS84
Glymphatic system clears extracellular tau and protects from tau aggregation and neurodegeneration82
STING agonist promotes CAR T cell trafficking and persistence in breast cancer81
Retrograde migration supplies resident memory T cells to lung-draining LN after influenza infection80
APOBEC3A catalyzes mutation and drives carcinogenesis in vivo80
Monocyte-derived macrophages promote breast cancer bone metastasis outgrowth80
Dnmt3a-mutated clonal hematopoiesis promotes osteoporosis79
Single-cell RNA sequencing of murine islets shows high cellular complexity at all stages of autoimmune diabetes76
The SIRPα–CD47 immune checkpoint in NK cells76
The RNA m6A reader YTHDF2 controls NK cell antitumor and antiviral immunity75
Tissue-resident memory T cell reactivation by diverse antigen-presenting cells imparts distinct functional responses75
Longevity and replenishment of human liver-resident memory T cells and mononuclear phagocytes71
Single cell analysis of M. tuberculosis phenotype and macrophage lineages in the infected lung71
Optimized gene engineering of murine CAR-T cells reveals the beneficial effects of IL-15 coexpression71
Antigen-responsive CD4+ T cell clones contribute to the HIV-1 latent reservoir69
Single-cell analyses identify circulating anti-tumor CD8 T cells and markers for their enrichment69
Distinct functions of tissue-resident and circulating memory Th2 cells in allergic airway disease69
Sensing of endogenous nucleic acids by ZBP1 induces keratinocyte necroptosis and skin inflammation68
A committed tissue-resident memory T cell precursor within the circulating CD8+ effector T cell pool68
Brain transforms natural killer cells that exacerbate brain edema after intracerebral hemorrhage67
Lung tumor MHCII immunity depends on in situ antigen presentation by fibroblasts67
TREM2-dependent lipid droplet biogenesis in phagocytes is required for remyelination66
Early nasal type I IFN immunity against SARS-CoV-2 is compromised in patients with autoantibodies against type I IFNs66
Mitophagy-mediated adipose inflammation contributes to type 2 diabetes with hepatic insulin resistance66
SARS-CoV-2 breakthrough infection in vaccinees induces virus-specific nasal-resident CD8+ and CD4+ T cells of broad specificity66
Single-cell analysis of human skin identifies CD14+ type 3 dendritic cells co-producing IL1B and IL23A in psoriasis66
SOAT1 promotes mevalonate pathway dependency in pancreatic cancer65
Germinal center–dependent and –independent memory B cells produced throughout the immune response62
A critical role for plasminogen in inflammation62
TCR signal strength defines distinct mechanisms of T cell dysfunction and cancer evasion61
Alveolar macrophages rely on GM-CSF from alveolar epithelial type 2 cells before and after birth60
Inhibition of macrophage histone demethylase JMJD3 protects against abdominal aortic aneurysms60
IL-21 is a broad negative regulator of IgE class switch recombination in mouse and human B cells60
Neuronal interleukin-1 receptors mediate pain in chronic inflammatory diseases59
Autoantibody-mediated impairment of DNASE1L3 activity in sporadic systemic lupus erythematosus59
Necroptosis restricts influenza A virus as a stand-alone cell death mechanism58
Endothelial LRP1 protects against neurodegeneration by blocking cyclophilin A58
HSV1 VP1-2 deubiquitinates STING to block type I interferon expression and promote brain infection57
TIM3+ TRBV11-2 T cells and IFNγ signature in patrolling monocytes and CD16+ NK cells delineate MIS-C56
Anti-tumor immunity in mismatch repair-deficient colorectal cancers requires type I IFN–driven CCL5 and CXCL1056
Intravenous administration of BCG protects mice against lethal SARS-CoV-2 challenge56
Sphingosine 1-phosphate receptor 5 (S1PR5) regulates the peripheral retention of tissue-resident lymphocytes55
Recessive inborn errors of type I IFN immunity in children with COVID-19 pneumonia54
Lipocalin-2 counteracts metabolic dysregulation in obesity and diabetes53
High microbiota reactivity of adult human intestinal IgA requires somatic mutations53
Immunogenicity and efficacy of one and two doses of Ad26.COV2.S COVID vaccine in adult and aged NHP53
Single-cell profiling reveals an endothelium-mediated immunomodulatory pathway in the eye choroid53
Human autoantibodies underlying infectious diseases52
Dominant-negative mutations in human IL6ST underlie hyper-IgE syndrome52
A TRPA1 inhibitor suppresses neurogenic inflammation and airway contraction for asthma treatment52
Immune asynchrony in COVID-19 pathogenesis and potential immunotherapies52
Mitochondrial metabolism supports resistance to IDH mutant inhibitors in acute myeloid leukemia51
The pleiotropic roles of leptin in metabolism, immunity, and cancer51
Normalization of cholesterol metabolism in spinal microglia alleviates neuropathic pain51
Mechanosensing through YAP controls T cell activation and metabolism51
Nicotine promotes brain metastasis by polarizing microglia and suppressing innate immune function51
Anti–IFN-γ autoantibodies underlie disseminated Talaromyces marneffei infections50
Type I interferon signaling mediates Mycobacterium tuberculosis–induced macrophage death50
AIM2 controls microglial inflammation to prevent experimental autoimmune encephalomyelitis49
LILRB4 suppresses immunity in solid tumors and is a potential target for immunotherapy49
Distinct fibroblast functional states drive clinical outcomes in ovarian cancer and are regulated by TCF2149
Conserved meningeal lymphatic drainage circuits in mice and humans49
Circulating clonally expanded T cells reflect functions of tumor-infiltrating T cells48
Aged hematopoietic stem cells are refractory to bloodborne systemic rejuvenation interventions47
Human marginal zone B cell development from early T2 progenitors46
PU.1 enforces quiescence and limits hematopoietic stem cell expansion during inflammatory stress46
NCKAP1L defects lead to a novel syndrome combining immunodeficiency, lymphoproliferation, and hyperinflammation46
Functional immune cell–astrocyte interactions46
The GM-CSF–IRF5 signaling axis in eosinophils promotes antitumor immunity through activation of type 1 T cell responses45
AKT-dependent NOTCH3 activation drives tumor progression in a model of mesenchymal colorectal cancer45
α-Synuclein modulates tau spreading in mouse brains45
Effects of dietary restriction on neuroinflammation in neurodegenerative diseases45
Lipid-loaded tumor-associated macrophages sustain tumor growth and invasiveness in prostate cancer45
Gut microbiota–driven brain Aβ amyloidosis in mice requires microglia44
Extracellular vesicle– and particle-mediated communication shapes innate and adaptive immune responses44
Exit from germinal center to become quiescent memory B cells depends on metabolic reprograming and provision of a survival signal44
Membrane budding is a major mechanism of in vivo platelet biogenesis44
Suppression of local type I interferon by gut microbiota–derived butyrate impairs antitumor effects of ionizing radiation44
Single-cell lineage mapping of a diverse virus-specific naive CD4 T cell repertoire44
Lessons from Toxoplasma: Host responses that mediate parasite control and the microbial effectors that subvert them43
Yolk sac, but not hematopoietic stem cell–derived progenitors, sustain erythropoiesis throughout murine embryonic life43
Vi-specific serological correlates of protection for typhoid fever43
Efficient gene knockout in primary human and murine myeloid cells by non-viral delivery of CRISPR-Cas943
A stem-loop RNA RIG-I agonist protects against acute and chronic SARS-CoV-2 infection in mice43
SIRT1–NOX4 signaling axis regulates cancer cachexia42
Chronic TREM2 activation exacerbates Aβ-associated tau seeding and spreading41
A robust platform for expansion and genome editing of primary human natural killer cells41
Limited rejuvenation of aged hematopoietic stem cells in young bone marrow niche41
Helicobacter pylori metabolites exacerbate gastritis through C-type lectin receptors40
In vivo labeling reveals continuous trafficking of TCF-1+ T cells between tumor and lymphoid tissue40
Loss of decay-accelerating factor triggers podocyte injury and glomerulosclerosis40
Plasmodium falciparum erythrocyte membrane protein 1 variants induce cell swelling and disrupt the blood–brain barrier in cerebral malaria40
Activation of 4-1BBL+ B cells with CD40 agonism and IFNγ elicits potent immunity against glioblastoma40
TGF-β and Eomes control the homeostasis of CD8+ regulatory T cells40
Neutrophils and COVID-19: Nots, NETs, and knots40
BACH2 drives quiescence and maintenance of resting Treg cells to promote homeostasis and cancer immunosuppression40
Plasmodium falciparum–specific IgM B cells dominate in children, expand with malaria, and produce functional IgM39
Intestinal epithelial tuft cell induction is negated by a murine helminth and its secreted products39
Preclinical validation of a potent γ-secretase modulator for Alzheimer’s disease prevention39
Lineage-specific regulation of inducible and constitutive mast cells in allergic airway inflammation39
Synaptic restoration by cAMP/PKA drives activity-dependent neuroprotection to motoneurons in ALS38
An NR2F1-specific agonist suppresses metastasis by inducing cancer cell dormancy38
Feeding-induced hepatokine, Manf, ameliorates diet-induced obesity by promoting adipose browning via p38 MAPK pathway38
Single-cell transcriptomic analysis of human colonic macrophages reveals niche-specific subsets38
Enhanced cGAS-STING–dependent interferon signaling associated with mutations in ATAD3A37
USP22 promotes IRF3 nuclear translocation and antiviral responses by deubiquitinating the importin protein KPNA237
Profiling HPV-16–specific T cell responses reveals broad antigen reactivities in oropharyngeal cancer patients37
The architectural design of CD8+ T cell responses in acute and chronic infection: Parallel structures with divergent fates37
Inflammatory signaling regulates hematopoietic stem and progenitor cell development and homeostasis37
Early type I IFN blockade improves the efficacy of viral vaccines36
Targeting CLK3 inhibits the progression of cholangiocarcinoma by reprogramming nucleotide metabolism36
MST4 kinase suppresses gastric tumorigenesis by limiting YAP activation via a non-canonical pathway35
Gut microbiome stability and dynamics in healthy donors and patients with non-gastrointestinal cancers35
Upregulation of VCAM-1 in lymphatic collectors supports dendritic cell entry and rapid migration to lymph nodes in inflammation35
Reversal of emphysema by restoration of pulmonary endothelial cells35
The T cell CD6 receptor operates a multitask signalosome with opposite functions in T cell activation35
Multi-omic comparison of Alzheimer’s variants in human ESC–derived microglia reveals convergence at APOE35
NLRC4 inflammasome activation is NLRP3- and phosphorylation-independent during infection and does not protect from melanoma34
Inhibition of ADAM17 impairs endothelial cell necroptosis and blocks metastasis34
P38 kinases mediate NLRP1 inflammasome activation after ribotoxic stress response and virus infection34
Blood transcriptomics reveal the evolution and resolution of the immune response in tuberculosis34
Lysosomal cathepsin creates chimeric epitopes for diabetogenic CD4 T cells via transpeptidation34
A Fas-4-1BB fusion protein converts a death to a pro-survival signal and enhances T cell therapy34
Blocking inflammation on the way: Rationale for CXCR2 antagonists for the treatment of COVID-1934
Rapid identification and characterization of infected cells in blood during chronic active Epstein-Barr virus infection34
C-type lectin Mincle mediates cell death–triggered inflammation in acute kidney injury33
Gut microbiota, NLR proteins, and intestinal homeostasis33
The current landscape of single-cell transcriptomics for cancer immunotherapy33
Adiponectin restrains ILC2 activation by AMPK-mediated feedback inhibition of IL-33 signaling33
Potent human broadly neutralizing antibodies to hepatitis B virus from natural controllers33
Memory B cell responses to Omicron subvariants after SARS-CoV-2 mRNA breakthrough infection in humans33
Inflammasome signaling in human placental trophoblasts regulates immune defense against Listeria monocytogenes infection33
AIM2 regulates anti-tumor immunity and is a viable therapeutic target for melanoma32
Modulating the quantity of HIV Env-specific CD4 T cell help promotes rare B cell responses in germinal centers32
Eosinophils are part of the granulocyte response in tuberculosis and promote host resistance in mice32
Autoantibodies against type I IFNs in patients with critical influenza pneumonia32
DNA damage contributes to neurotoxic inflammation in Aicardi-Goutières syndrome astrocytes32
The metabolism-modulating activity of IL-17 signaling in health and disease31
Nicotinamide nucleotide transhydrogenase regulates mitochondrial metabolism in NSCLC through maintenance of Fe-S protein function31
A high OXPHOS CD8 T cell subset is predictive of immunotherapy resistance in melanoma patients31
Life-threatening viral disease in a novel form of autosomal recessive IFNAR2 deficiency in the Arctic31
TRIM24 facilitates antiviral immunity through mediating K63-linked TRAF3 ubiquitination31
T reg–specific insulin receptor deletion prevents diet-induced and age-associated metabolic syndrome31
Integration features of intact latent HIV-1 in CD4+ T cell clones contribute to viral persistence31
Biochemically deleterious human NFKB1 variants underlie an autosomal dominant form of common variable immunodeficiency31
Cancer cell CCR2 orchestrates suppression of the adaptive immune response31
A human mutation in STAT3 promotes type 1 diabetes through a defect in CD8+ T cell tolerance30
Potent human broadly SARS-CoV-2–neutralizing IgA and IgG antibodies effective against Omicron BA.1 and BA.230
Sustained androgen receptor signaling is a determinant of melanoma cell growth potential and tumorigenesis30
Combined deletion of Bap1, Nf2, and Cdkn2ab causes rapid onset of malignant mesothelioma in mice30
High-efficiency nonviral CRISPR/Cas9-mediated gene editing of human T cells using plasmid donor DNA30
Critical requirement for BCR, BAFF, and BAFFR in memory B cell survival30
PGD2 and CRTH2 counteract Type 2 cytokine–elicited intestinal epithelial responses during helminth infection30
Diagnostic blood RNA profiles for human acute spinal cord injury30
CD4+ T cells in the lungs of acute sarcoidosis patients recognize an Aspergillus nidulans epitope30
Circadian immune circuits30
CD4+ follicular regulatory T cells optimize the influenza virus–specific B cell response30
Chronic interleukin-1 exposure triggers selection for Cebpa-knockout multipotent hematopoietic progenitors30
Platelets orchestrate the resolution of pulmonary inflammation in mice by T reg cell repositioning and macrophage education30
Activation of the integrated stress response confers vulnerability to mitoribosome-targeting antibiotics in melanoma30
Immunotherapy during the acute SHIV infection of macaques confers long-term suppression of viremia30
Cerebral cavernous malformations are driven by ADAMTS5 proteolysis of versican30
Meteorin-like/Meteorin-β protects heart against cardiac dysfunction30
T reg cell–intrinsic requirements for ST2 signaling in health and neuroinflammation30
Role of adipose tissue macrophages in obesity-related disorders30
Suppressive effects of the obese tumor microenvironment on CD8 T cell infiltration and effector function30
PMN-derived netrin-1 attenuates cardiac ischemia-reperfusion injury via myeloid ADORA2B signaling29
Reduced Ebola vaccine responses in CMV+ young adults is associated with expansion of CD57+KLRG1+ T cells29
Human resident memory T cells exit the skin and mediate systemic Th2-driven inflammation29
Vincristine-induced peripheral neuropathy is driven by canonical NLRP3 activation and IL-1β release29
A growth factor–expressing macrophage subpopulation orchestrates regenerative inflammation via GDF-1529
Circulating tumor cells: Ready for translation?29
Group 2 innate lymphoid cells support hematopoietic recovery under stress conditions29
Characterization of human FDCs reveals regulation of T cells and antigen presentation to B cells29
BTK operates a phospho-tyrosine switch to regulate NLRP3 inflammasome activity29
The molecular and epigenetic mechanisms of innate lymphoid cell (ILC) memory and its relevance for asthma29
Human STAT3 variants underlie autosomal dominant hyper-IgE syndrome by negative dominance29
Neutrophil-specific gain-of-function mutations in Nlrp3 promote development of cryopyrin-associated periodic syndrome29
Constrained chromatin accessibility in PU.1-mutated agammaglobulinemia patients29
Glioma stem-like cells evade interferon suppression through MBD3/NuRD complex–mediated STAT1 downregulation29
Molecular architecture determines brain delivery of a transferrin receptor–targeted lysosomal enzyme28
Simultaneously targeting cancer-associated fibroblasts and angiogenic vessel as a treatment for TNBC28
Genome-wide mutational signatures revealed distinct developmental paths for human B cell lymphomas28
A loss-of-function IFNAR1 allele in Polynesia underlies severe viral diseases in homozygotes28
CD16+CD163+ monocytes traffic to sites of inflammation during necrotizing enterocolitis in premature infants28
Noncanonical STAT3 activity sustains pathogenic Th17 proliferation and cytokine response to antigen28
Constructing and deconstructing GATA2-regulated cell fate programs to establish developmental trajectories28
Human germline heterozygous gain-of-functionSTAT6variants cause severe allergic disease28
Influenza infection fortifies local lymph nodes to promote lung-resident heterosubtypic immunity28
Serum HBsAg clearance has minimal impact on CD8+ T cell responses in mouse models of HBV infection28
LYVE1+ macrophages of murine peritoneal mesothelium promote omentum-independent ovarian tumor growth28
Foxo1 controls gut homeostasis and commensalism by regulating mucus secretion28
A partial form of inherited human USP18 deficiency underlies infection and inflammation27
Clonal lineage tracing reveals mechanisms skewing CD8+ T cell fate decisions in chronic infection27
TGF-β regulates the stem-like state of PD-1+ TCF-1+ virus-specific CD8 T cells during chronic infection27
Hypoxia-inducible factors individually facilitate inflammatory myeloid metabolism and inefficient cardiac repair27
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