OOIR: Observatory of International Research

Papers

(The TQCC of Journal of Experimental Medicine is 64. The table below lists those papers that are above that threshold based on CrossRef citation counts. The publications cover those that have been published in the past four years, i.e., from 2019-03-01 to 2023-03-01.)

Article	Citations
Distinct populations of inflammatory fibroblasts and myofibroblasts in pancreatic cancer	1157
Inflammasomes are activated in response to SARS-CoV-2 infection and are associated with COVID-19 severity in patients	396
The gut microbiome: Relationships with disease and opportunities for therapy	375
Resting Respiratory Tract Dendritic Cells Preferentially Stimulate T Helper Cell Type 2 (Th2) Responses and Require Obligatory Cytokine Signals for Induction of Th1 Immunity	359
Type I interferon–mediated monogenic autoinflammation: The type I interferonopathies, a conceptual overview	286
Context-dependent EMT programs in cancer metastasis	284
Nucleoside-modified mRNA vaccines induce potent T follicular helper and germinal center B cell responses	281
Oxidized mitochondrial nucleoids released by neutrophils drive type I interferon production in human lupus	276
Widespread transneuronal propagation of α-synucleinopathy triggered in olfactory bulb mimics prodromal Parkinson’s disease	266
Development and plasticity of meningeal lymphatic vessels	227
Detection of interferon alpha protein reveals differential levels and cellular sources in disease	226
Biology and therapeutic potential of interleukin-10	206
T-bet negatively regulates autoimmune myocarditis by suppressing local production of interleukin 17	202
Neutrophils facilitate ovarian cancer premetastatic niche formation in the omentum	195
Microbiome–microglia connections via the gut–brain axis	186
IgA regulates the composition and metabolic function of gut microbiota by promoting symbiosis between bacteria	177
Microglia drive APOE-dependent neurodegeneration in a tauopathy mouse model	173
Androgen signaling negatively controls group 2 innate lymphoid cells	168
Ticks produce highly selective chemokine binding proteins with antiinflammatory activity	164
Macrophages of distinct origins contribute to tumor development in the lung	156
CXCR6 regulates localization of tissue-resident memory CD8 T cells to the airways	155
Single-cell transcriptome analysis reveals differential nutrient absorption functions in human intestine	152
A major role for ferroptosis in Mycobacterium tuberculosis–induced cell death and tissue necrosis	145
Predicting the response to CTLA-4 blockade by longitudinal noninvasive monitoring of CD8 T cells	143
COVID-19 and emerging viral infections: The case for interferon lambda	143
Inflammasome signaling and regulation of interleukin-1 family cytokines	141
NK cells switch from granzyme B to death receptor–mediated cytotoxicity during serial killing	137
Commensal microbes provide first line defense against Listeria monocytogenes infection	136
Toxoplasma gondii TgIST co-opts host chromatin repressors dampening STAT1-dependent gene regulation and IFN-γ–mediated host defenses	134
Gasdermins and their role in immunity and inflammation	126
Interferon-induced guanylate-binding proteins: Guardians of host defense in health and disease	122
Immune cells and CNS physiology: Microglia and beyond	122
Secreted PD-L1 variants mediate resistance to PD-L1 blockade therapy in non–small cell lung cancer	122
Life-threatening influenza pneumonitis in a child with inherited IRF9 deficiency	122
Preexisting autoantibodies to type I IFNs underlie critical COVID-19 pneumonia in patients with APS-1	122
Tissue-resident macrophages in omentum promote metastatic spread of ovarian cancer	119
Fyn kinase regulates misfolded α-synuclein uptake and NLRP3 inflammasome activation in microglia	118
Loss of the interleukin-6 receptor causes immunodeficiency, atopy, and abnormal inflammatory responses	118
CD4+ resident memory T cells dominate immunosurveillance and orchestrate local recall responses	116
GM-CSF in inflammation	116
STING-mediated disruption of calcium homeostasis chronically activates ER stress and primes T cell death	116
Single-cell transcriptomic analysis of tissue-resident memory T cells in human lung cancer	115
Sex-specific effects of microbiome perturbations on cerebral Aβ amyloidosis and microglia phenotypes	114
Phenotypical and functional alteration of unconventional T cells in severe COVID-19 patients	111
Viral entry and escape from antibody-mediated neutralization influence hepatitis C virus reinfection in liver transplantation	111
Metronomic chemotherapy prevents therapy-induced stromal activation and induction of tumor-initiating cells	110
Innate immune priming in the absence of TAK1 drives RIPK1 kinase activity–independent pyroptosis, apoptosis, necroptosis, and inflammatory disease	107
CSF-1 controls cerebellar microglia and is required for motor function and social interaction	106
A common transcriptomic program acquired in the thymus defines tissue residency of MAIT and NKT subsets	105
Severe influenza pneumonitis in children with inherited TLR3 deficiency	104
Intratumoral accumulation of gut microbiota facilitates CD47-based immunotherapy via STING signaling	104
Inherited CD70 deficiency in humans reveals a critical role for the CD70–CD27 pathway in immunity to Epstein-Barr virus infection	103
Inherited IFNAR1 deficiency in otherwise healthy patients with adverse reaction to measles and yellow fever live vaccines	103
Specific targeting of CD163+ TAMs mobilizes inflammatory monocytes and promotes T cell–mediated tumor regression	101
Inhibiting antibiotic-resistant Enterobacteriaceae by microbiota-mediated intracellular acidification	101
Human dendritic cells (DCs) are derived from distinct circulating precursors that are precommitted to become CD1c+ or CD141+ DCs	100
Immune regulation by glucocorticoids can be linked to cell type–dependent transcriptional responses	100
Human histocompatibility leukocyte antigen (HLA)-DM edits peptides presented by HLA-DR according to their ligand binding motifs.	100
Heterotypic CAF-tumor spheroids promote early peritoneal metastasis of ovarian cancer	100
Development of immune checkpoint therapy for cancer	99
A noncanonical function of cGAMP in inflammasome priming and activation	99
CCL22 controls immunity by promoting regulatory T cell communication with dendritic cells in lymph nodes	99
Th1 effector T cells selectively orchestrate cardiac fibrosis in nonischemic heart failure	98
Caveolin-1 selectively regulates microRNA sorting into microvesicles after noxious stimuli	97
A novel disorder involving dyshematopoiesis, inflammation, and HLH due to aberrant CDC42 function	97
Type I interferon induces CXCL13 to support ectopic germinal center formation	95
High mobility group box 1 orchestrates tissue regeneration via CXCR4	94
Mutations in COPA lead to abnormal trafficking of STING to the Golgi and interferon signaling	93
SHP2 inhibition diminishes KRASG12C cycling and promotes tumor microenvironment remodeling	93
Primary prostate cancer educates bone stroma through exosomal pyruvate kinase M2 to promote bone metastasis	91
Auto-antibodies to type I IFNs can underlie adverse reactions to yellow fever live attenuated vaccine	91
Ontogeny of human mucosal-associated invariant T cells and related T cell subsets	90
Prostate-specific membrane antigen cleavage of vitamin B9 stimulates oncogenic signaling through metabotropic glutamate receptors	89
Inflammatory microcrystals differentially regulate the secretion of macrophage inflammatory protein 1 and interleukin 8 by human neutrophils: a possible mechanism of neutrophil recruitment to sites of	88
Myeloid-targeted immunotherapies act in synergy to induce inflammation and antitumor immunity	87
Gene therapy targeting SARM1 blocks pathological axon degeneration in mice	86
Antigen-presenting ILC3 regulate T cell–dependent IgA responses to colonic mucosal bacteria	86
Gasdermin D in peripheral myeloid cells drives neuroinflammation in experimental autoimmune encephalomyelitis	85
Critical role for Sec22b-dependent antigen cross-presentation in antitumor immunity	85
Wnt5a induces and maintains prostate cancer cells dormancy in bone	84
Dual T cell– and B cell–intrinsic deficiency in humans with biallelic RLTPR mutations	83
High-dimensional single-cell analysis reveals the immune signature of narcolepsy	83
Acetate coordinates neutrophil and ILC3 responses against C. difficile through FFAR2	83
Astrocytes and microglia: Models and tools	83
Use of extracellular vesicles from lymphatic drainage as surrogate markers of melanoma progression and BRAFV600E mutation	82
A stromal cell niche sustains ILC2-mediated type-2 conditioning in adipose tissue	81
SARS-CoV-2 induces human plasmacytoid predendritic cell diversification via UNC93B and IRAK4	80
The role of interleukin-17 in tumor development and progression	80
Unveiling skin macrophage dynamics explains both tattoo persistence and strenuous removal	79
LncRNA-encoded polypeptide ASRPS inhibits triple-negative breast cancer angiogenesis	79
Modulating inflammation for cancer therapy	77
Tumor-associated factors are enriched in lymphatic exudate compared to plasma in metastatic melanoma patients	77
Single-cell imaging of CAR T cell activity in vivo reveals extensive functional and anatomical heterogeneity	77
ZEB1, ZEB2, and the miR-200 family form a counterregulatory network to regulate CD8+ T cell fates	76
KLRG1 and NKp46 discriminate subpopulations of human CD117+CRTH2− ILCs biased toward ILC2 or ILC3	75
Resident memory CD8 T cells persist for years in human small intestine	73
Type III interferons: Balancing tissue tolerance and resistance to pathogen invasion	71
Sweetening the hallmarks of cancer: Galectins as multifunctional mediators of tumor progression	71
Vasculature-associated fat macrophages readily adapt to inflammatory and metabolic challenges	71
Expression of factor V by resident macrophages boosts host defense in the peritoneal cavity	70
Contrasting requirements during disease evolution identify EZH2 as a therapeutic target in AML	70
SARS-CoV-2–related MIS-C: A key to the viral and genetic causes of Kawasaki disease?	70
Toward a better understanding of folate metabolism in health and disease	69
Human RELA haploinsufficiency results in autosomal-dominant chronic mucocutaneous ulceration	68
ILC2s are the predominant source of intestinal ILC-derived IL-10	68
Somatic activating mutations in PIK3CA cause generalized lymphatic anomaly	68
Metabolically activated adipose tissue macrophages link obesity to triple-negative breast cancer	66
Combination of quadruplex qPCR and next-generation sequencing for qualitative and quantitative analysis of the HIV-1 latent reservoir	66
Chromatin landscapes reveal developmentally encoded transcriptional states that define human glioblastoma	65
Single-cell analysis of the cellular heterogeneity and interactions in the injured mouse spinal cord	64
Impact of naturally forming human α/β-tryptase heterotetramers in the pathogenesis of hereditary α-tryptasemia	64
Effects of interleukin-2 in immunostimulation and immunosuppression	64