Journal of Experimental Medicine

Article	Citations
Early innate role for CD8αα+ cells in tuberculosis	236
S1PR1, an endothelial-immune influencer	162
ALK2/3 recruitment to the immunological synapse is required for T cell activation and death	147
Local gene editing of fibroblasts in tumors reveals a new cancer-associated fibroblast state	135
Primary tumor–derived systemic nANGPTL4 inhibits metastasis	129
Differential IL-12 signaling induces human natural killer cell activating receptor-mediated ligand-specific expansion	115
Epitope and HLA specificity of human TCRs against Plasmodium falciparum circumsporozoite protein	115
The pathogenic role of retinoid nuclear receptor signaling in cancer and metabolic syndromes	110
Intestinal epithelial c-Maf expression determines enterocyte differentiation and nutrient uptake in mice	110
Inhibition of astrocytic DRD2 suppresses CNS inflammation in an animal model of multiple sclerosis	109
SARS-CoV-2 Spike protein suppresses CTL-mediated killing by inhibiting immune synapse assembly	108
Antigen-independent, autonomous B cell receptor signaling drives activated B cell DLBCL	102
Host factor TIMP1 sustains long-lasting myeloid-biased hematopoiesis after severe infection	100
Antibody feedback contributes to facilitating the development of Omicron-reactive memory B cells in SARS-CoV-2 mRNA vaccinees	99
IL-21 shapes germinal center polarization via light zone B cell selection and cyclin D3 upregulation	95
RORγt eTACs mediate oral tolerance and Treg induction	95
B cell receptor ligation induces IgE plasma cell elimination	94
Prenatally derived macrophages support choroidal health and decline in age-related macular degeneration	92
High burden of viruses and bacterial pathobionts drives heightened nasal innate immunity in children	90
An iron-rich subset of macrophages promotes tumor growth through a Bach1-Ednrb axis	87
Common cold embecovirus imprinting primes broadly neutralizing antibody responses to SARS-CoV-2 S2	87
IFNγ score–based neoadjuvant immunotherapy for stage III melanoma	85
Obesity alters monocyte developmental trajectories to enhance metastasis	84
Heterozygous human JAK2V617F activates AhR to drive essential thrombocythemia and promote thrombosis	84
The genetic background shapes the susceptibility to mitochondrial dysfunction and NASH progression	83

Lymphatic chain gradients regulate the magnitude and heterogeneity of T cell responses to vaccination	83
Transit-amplifying cells control R-spondins in the mouse crypt to modulate intestinal stem cell proliferation	82
A human STAT3 gain-of-function variant drives local Th17 dysregulation and skin inflammation in mice	82
pDCs, type 1 IFN, and the female predileXion of SSc	79
T cell engagers emerge as a compelling therapeutic modality	77
Challenges in TB research	76
Non-professional efferocytosis of Salmonella-infected intestinal epithelial cells in the neonatal host	75
NFAT5 governs cellular plasticity-driven resistance to KRAS-targeted therapy in pancreatic cancer	74
Loss of ATG7 in microglia impairs UPR, triggers ferroptosis, and weakens amyloid pathology control	74
Dual role of vascular endothelial growth factor-C in post-stroke recovery	73
TIGIT mediates activation-induced cell death of ILC2s during chronic airway allergy	73
Correction: ICAM-1 controls development and function of ILC2	70
CD8+ T cell depletion prevents neuropathology in a mouse model of globoid cell leukodystrophy	70
Correction: Segmented filamentous bacteria–induced epithelial MHCII regulates cognate CD4+ IELs and epithelial turnover	69
CXCL12+ dermal fibroblasts promote neutrophil recruitment and host defense by recognition of IL-17	69
How decreasing T cell signaling unexpectedly results in autoimmunity	68
Nina Cabezas Wallscheid: Enjoying the freedom to decide my research path	67
Michelle Linterman: We are always learning	67
Spatiotemporal dynamics of fetal liver hematopoietic niches	65
Protein arginine methyltransferase 1 regulates B cell fate after positive selection in the germinal center in mice	64
MYC is a clinically significant driver of mTOR inhibitor resistance in breast cancer	64
Tingible body macrophages: Gargantuan chameleons of the germinal center	63
IEC-intrinsic IL-1R signaling holds dual roles in regulating intestinal homeostasis and inflammation	60
Memory B cell responses to Omicron subvariants after SARS-CoV-2 mRNA breakthrough infection in humans	58
Rethinking disomy: Autosomal expression bias	58
A twist in the tail: Of T cell subsets and disease	58
Somatic gain-of-function mutations in BUD13 promote oncogenesis by disrupting Fbw7 function	57
Oral antigen exposure under costimulation blockade induces Treg cells to establish immune tolerance	57
MYO1F in neutrophils is required for the response to immune checkpoint blockade therapy	56
Functional specialization of short-lived and long-lived macrophage subsets in human tonsils	55
Amino acid availability acts as a metabolic rheostat to determine the magnitude of ILC2 responses	54
Inherited human ITK deficiency impairs IFN-γ immunity and underlies tuberculosis	53
Protective fibroblastic niches in secondary lymphoid organs	53
CXCR4+ Treg cells control serum IgM levels and natural IgM autoantibody production by B-1 cells in the bone marrow	52
Targeting infection-specific peptides in immunopeptidomics studies for vaccine target discovery	52
Augmenting neurogenesis rescues memory impairments in Alzheimer’s disease by restoring the memory-storing neurons	52
Promiscuous recognition of MR1 drives self-reactive mucosal-associated invariant T cell responses	51
PRECISE-seq reveals disease-relevant TCR repertoires with phenotypic plasticity	51
CD150-dependent hematopoietic stem cell sensing of Brucella instructs myeloid commitment	51
Immunomolecular and reactivity landscapes of gut IgA subclasses in homeostasis and inflammatory bowel disease	51
Pleiotrophin drives a prometastatic immune niche in breast cancer	50
Dietary intervention preserves β cell function in mice through CTCF-mediated transcriptional reprogramming	50
Deficiency for SAMHD1 activates MDA5 in a cGAS/STING-dependent manner	49
CTLA4 prohibits T cells from cross-dressing	49
Sara Suliman: Science is better when it’s shared	49
Changing behind the scenes	48
Correction: SCFβ-TRCP suppresses angiogenesis and thyroid cancer cell migration by promoting ubiquitination and destruction of VEGF receptor 2	48
Correction: Chromatin landscapes reveal developmentally encoded transcriptional states that define human glioblastoma	47
Correction: REV-ERB regulates RORγt+ regulatory T cell specification and function through the Bhlhe40-c-Maf axis	47
Ki67 deficiency impedes chromatin accessibility and BCR gene rearrangement	46

Correction: Mouse model of SARS-CoV-2 reveals inflammatory role of type I interferon signaling	46
Chimeric MHC class I– and II–restricted non-self epitopes broaden antitumor T cell reactions	45
Correction: B cell tolerance and antibody production to the celiac disease autoantigen transglutaminase 2	44
TET2–STAT3–CXCL5 nexus promotes neutrophil lipid transfer to fuel lung adeno-to-squamous transition	44
The common HAQ STING allele prevents clinical penetrance of COPA syndrome	43
Targeting neuroinflammation in neuropathic pain and opioid use	43
Tumor-derived OBP2A promotes prostate cancer castration resistance	43
Epigenetic and metabolic reprogramming support plasma cell differentiation in germinal centers	43
IgD from atypical-like memory B cells and plasma cells targets commensal and environmental antigens	42
TCR signaling induces STAT3 phosphorylation to promote TH17 cell differentiation	42
Macrophages in the synovial lining niche initiate neutrophil recruitment and articular inflammation	42
Altered X-chromosome inactivation of the TLR7/8 locus and heterogeneity of pDCs in systemic sclerosis	42
Gain-of-function human UNC93B1 variants cause systemic lupus erythematosus and chilblain lupus	41
CD4+ T cell dysfunction in cancer	41
NK cell expansion requires HuR and mediates control of solid tumors and long-term virus infection	41
Differential impact of lymphatic outflow pathways on cerebrospinal fluid homeostasis	41
Activating NO–sGC crosstalk in the mouse vascular niche promotes vascular integrity and mitigates acute lung injury	40
Regulatory T cells converted from Th1 cells in tumors suppress cancer immunity via CD39	40
Correction: Role of affinity in plasma cell development in the germinal center light zone	40
Hnf4 activates mimetic-cell enhancers to recapitulate gut and liver development within the thymus	40
CAR-T cell manufacturing: Major process parameters and next-generation strategies	40
Perfecting antigen prediction	38
Women in STEM becoming independent: The journey to independence is an immensely gratifying odyssey	38
Immature B cell homing shapes human lymphoid tissue structure and function	38
Laura Mackay: Don't be afraid to engage	38
Correction: Precursor central memory versus effector cell fate and naïve CD4+ T cell heterogeneity	37
Correction: Antigen-presenting autoreactive B cells activate regulatory T cells and suppress autoimmune arthritis in mice	37
IFNγ-induced memory in human macrophages is sustained by the durability of cytokine signaling itself	37
Correction: Context-dependent effects of IL-2 rewire immunity into distinct cellular circuits	37
Age- and diet-instructed metabolic rewiring of the tumor–immune microenvironment	37
Correction: Profiling HPV-16–specific T cell responses reveals broad antigen reactivities in oropharyngeal cancer patients	37
Liver-X-receptor agonism enhances T cell priming and activation to promote anti-tumor immunity	37
Competitive fungal commensalism mitigates candidiasis pathology	36
MHC one–two punch knocks out cancer	36
Coxsackievirus A10 impairs nail regeneration and induces onychomadesis by mimicking DKK1 to attenuate Wnt signaling	36
A cell-free antigen processing system informs HIV-1 epitope selection and vaccine design	36
Addendum: Resolvins suppress tumor growth and enhance cancer therapy	36
Cigarette smoke components modulate the MR1–MAIT axis	35
Loss of ARID3A perturbs intestinal epithelial proliferation–differentiation ratio and regeneration	35
Distinct fibroblast progenitor subpopulation expedites regenerative mucosal healing by immunomodulation	35
Neonatal microbiota colonization primes maturation of goblet cell–mediated protection in the pre-weaning colon	35
Hemifacial myohyperplasia is due to somatic muscular PIK3CA gain-of-function mutations and responds to pharmacological inhibition	35
Staying IgD positive in a challenging environment	35
CD163+ macrophages monitor enhanced permeability at the blood–dorsal root ganglion barrier	34
A path forward for Staphylococcus aureus vaccine development	34
Succinate-producing microbiota drives tuft cell hyperplasia to protect against Clostridioides difficile	34
Chronic activation of pDCs in autoimmunity is linked to dysregulated ER stress and metabolic responses	34
CSF1R-dependent CD169-positive macrophages locally constrain melanoma growth in the skin	34
Intravital imaging of pulmonary lymphatics in inflammation and metastatic cancer	34
HMCN1 variants aggravate epidermolysis bullosa simplex phenotype	33
Dominant negative OTULIN-related autoinflammatory syndrome	33
Stalled but not forgotten: Bacterial exotoxins inhibit translation to activate NLRP1	33
Dynamic Foxp3–chromatin interaction controls tunable Treg cell function	33
Immunologic signatures of response and resistance to nivolumab with ipilimumab in advanced metastatic cancer	33
Vision rescue via unconstrained in vivo prime editing in degenerating neural retinas	33
Rare SH2B3 coding variants in lupus patients impair B cell tolerance and predispose to autoimmunity	33
Charting the meningeal lymphatic network	32
CD4+ T helper 2 cells suppress breast cancer by inducing terminal differentiation	32
In vivo CRISPR/Cas9 screens identify new regulators of B cell activation and plasma cell differentiation	32
RAC2 gain-of-function variants causing inborn error of immunity drive NLRP3 inflammasome activation	32
Iron TAMs: The fallen protectors	32
Megakaryopoiesis impairment through acute innate immune signaling activation by azacitidine	31
Individuals with JAK1 variants are affected by syndromic features encompassing autoimmunity, atopy, colitis, and dermatitis	31
Urine scRNAseq reveals new insights into the bladder tumor immune microenvironment	31
RIPK1 S161 phosphorylation promotes further autophosphorylation and cecal necroptosis in TNF-treated mice	31
Tumor-instructed glutamine synthesis in cancer-associated fibroblasts promotes pro-tumor macrophages	31
Nucleotide modifications enable rational design of TLR7-selective ligands by blocking RNase cleavage	31
Membrane-IL12 adjuvant mRNA vaccine polarizes pre-effector T cells for optimized tumor control	31
Recessive inborn errors of type I IFN immunity in children with COVID-19 pneumonia	30
Repurposing a tricyclic antidepressant in tumor and metabolism disease treatment through fatty acid uptake inhibition	30
Glucosamine amends CNS pathology in mucopolysaccharidosis IIIC mouse expressing misfolded HGSNAT	29
Th17-to-Tfh plasticity during periodontitis limits disease pathology	29
VEGF-C prophylaxis favors lymphatic drainage and modulates neuroinflammation in a stroke model	29
Role of PRC2 in the stochastic expression of Aire target genes and development of mimetic cells in the thymus	29
Eating away T cell responses in lung cancer	29
Correction: TRAF3–EWSR1 signaling axis acts as a checkpoint on germinal center responses	29
No added sugar: CCDC134 stabilizes ER chaperone Gp96 for TLR biogenesis	29
Pathogenic autoantibodies to IFN-γ act through the impedance of receptor assembly and Fc-mediated response	29
B7 costimulation antagonizes RORγt+ regulatory T cells and immune tolerance in the intestine	28
Splenic cDC1 efferocytosis and cross-presentation to CD8 T cells are promoted by GPR34 and lysophosphatidylserine	28

Does fever drive the evolution of antiviral genes?	28
Macro-clusters: CD301b+ DCs prime Th2 responses	28
Tumor-associated neutrophils attenuate the immunosensitivity of hepatocellular carcinoma	28
Human CARMIL2 deficiency underlies a broader immunological and clinical phenotype than CD28 deficiency	28
Distinct molecular profiles drive multifaceted characteristics of colorectal cancer metastatic seeds	28
Clonal lineage tracing reveals mechanisms skewing CD8+ T cell fate decisions in chronic infection	28
The PML hub: An emerging actor of leukemia therapies	28
Microbiota and adipocyte mitochondrial damage in type 2 diabetes are linked by Mmp12+ macrophages	27
STAT3 gain of function: Too much of a good thing in the skin!	27
The stunning clodronate	27
The X factor in neurodegeneration	27
Use of 3M-052-AF with Alum adjuvant in HIV trimer vaccine induces human autologous neutralizing antibodies	27
XPR1 regulates fetal liver macrophage development, identity, and pyrenocyte clearance	27
Heterologous mucosal vaccine boosting enhances mucosal and systemic immunity by distinct mechanisms	27
Expression of Concern: ΔNp73, A Dominant-Negative Inhibitor of Wild-type p53 and TAp73, Is Up-regulated in Human Tumors	27
Targeting UBE2F induces a resilience program enhancing CD8 T cell immunity	27
Gut dysbiosis from high-salt diet promotes glioma via propionate-mediated TGF-β activation	27
Stopping the fat: Repurposing an antidepressant for cancer treatment	27
Linda-Gail Bekker: Mentorship is critical for anyone in STEM	27
S1PR1 regulates lymphatic valve development and tertiary lymphoid organ formation in the ileum	27
KLF2 expression in IgG plasma cells at their induction site regulates the migration program	26
Delineating a serotonin 1B receptor circuit for appetite suppression in mice	26
Recurrent infection transiently expands human tissue T cells while maintaining long-term homeostasis	26
Emerging in vivo tools for ILC2 research	26
A PI3Kδ-Foxo1-FasL signaling amplification loop rewires CD4+ T cell signaling and differentiation	26
Act1 drives chemoresistance via regulation of antioxidant RNA metabolism and redox homeostasis	26
PARP7 inhibits type I interferon signaling to prevent autoimmunity and lung disease	26
Lymph node metastasis: An immunological burden	26
Mechanosensing regulates pDC activation in the skin through NRF2 activation	25
Modeling memory B cell responses in a lymphoid organ-chip to evaluate mRNA vaccine boosting	25
Baseline colitogenicity and acute perturbations of gut microbiota in immunotherapy-related colitis	25
Myeloid diversity in tumors: Shaped by genes, location, and time	25
OX40L-expressing recombinant modified vaccinia virus Ankara induces potent antitumor immunity via reprogramming Tregs	24
Periductal fibroblasts participate in liver homeostasis, fibrosis, and tumorigenesis	24
Filamin A editing in myeloid cells reduces intestinal inflammation and protects from colitis	24
Landscape of mast cell populations across organs in mice and humans	24
A TNF-IL-1 circuit controls Yersinia within intestinal pyogranulomas	24
Correction: Hepatic IRE1α-XBP1 signaling promotes GDF15-mediated anorexia and body weight loss in chemotherapy	24
Guardians of the oral barriers	24
Five decades of natural killer cell discovery	24
Correction: Single-cell analysis of the cellular heterogeneity and interactions in the injured mouse spinal cord	24
Identifying genetic errors of immunity due to mosaicism	24
OTULIN and Muller’s morphs	23
Next-generation CRISPR screens enable causal systems immunology	23
A viral E3 ubiquitin ligase produced by herpes simplex virus 1 inhibits the NLRP1 inflammasome	23
Lymphatic transport in anti-tumor immunity and metastasis	23
Perturbation of calreticulin potentiates CD8+ T cell–mediated antitumor immunity	23
Repertoire, function, and structure of serological antibodies induced by the R21/Matrix-M malaria vaccine	23
Stability and heterogeneity in the antimicrobiota reactivity of human milk-derived immunoglobulin A	23
Mutations disrupting the kinase domain of IKKα lead to immunodeficiency and immune dysregulation in humans	23
BATF represses BIM to sustain tolerant T cells in the periphery	22
Trained immunity of alveolar macrophages enhances injury resolution via KLF4-MERTK-mediated efferocytosis	22
NADPH oxidase exerts a B cell–intrinsic contribution to lupus risk by modulating endosomal TLR signals	22
Mitochondrial pyruvate metabolism and glutaminolysis toggle steady-state and emergency myelopoiesis	22
In vivo antibody diversification targeting a conserved coronavirus epitope	22
Tumor cell–intrinsic Piezo2 drives radioresistance by impairing CD8+ T cell stemness maintenance	22
An engineered concealed IL-15-R elicits tumor-specific CD8+T cell responses through PD-1-cis delivery	22
A “multi-omics” analysis of blood–brain barrier and synaptic dysfunction in APOE4 mice	22
PD-1 and TIM-3 differentially regulate subsets of mouse IL-17A–producing γδ T cells	22
Immunopathological and microbial signatures of inflammatory bowel disease in partial RAG deficiency	22
A half-century of research on tuberculosis: Successes and challenges	22
Loss of tolerance precedes triggering and lifelong persistence of pathogenic type I interferon autoantibodies	21
Transfer of nuclear and ribosomal material from Sox10-lineage cells to neurons in the mouse brain	21
Kids’ noses resist COVID-19	21
Design and characterization of HIV-1 vaccine candidates to elicit antibodies targeting multiple epitopes	21
Single-cell and spatial profiling highlights TB-induced myofibroblasts as drivers of lung pathology	21
Slow cycling and durable Flt3+ progenitors contribute to hematopoiesis under native conditions	21
Inositol phosphatase INPP4B sustains ILC1s and intratumoral NK cells through an AKT-driven pathway	21
Correction: Respiratory viral infections in otherwise healthy humans with inherited IRF7 deficiency	21
Dynamic alterations of dural and bone marrow B cells in an animal model of progressive multiple sclerosis	21
The cribriform plate: A dynamic central nervous system–immune hub	21
EML4-ALK fusions drive lung adeno-to-squamous transition through JAK-STAT activation	21
Dynamics of natural and pharmacologic control of an SIV variant with an envelope trafficking defect	21
Developing high-affinity decoy receptors to treat multiple myeloma and diffuse large B cell lymphoma	20
MCRS1 sensitizes T cell–dependent immunotherapy by augmenting MHC-I expression in solid tumors	20
Fetal MAVS and type I IFN signaling pathways control ZIKV infection in the placenta and maternal decidua	20
Incontinentia pigmenti underlies thymic dysplasia, autoantibodies to type I IFNs, and viral diseases	20
Inflammatory and tolerogenic myeloid cells determine outcome following human allergen challenge	20
Who gets the calories? An endothelial checkpoint for fat expansion	20
Correction: Mitophagy-mediated adipose inflammation contributes to type 2 diabetes with hepatic insulin resistance	20
Women in STEM becoming independent: Put science and discovery ahead of your ego	20
Tet2 deficiency–induced expansion of monocyte-derived macrophages promotes liver fibrosis	20
ICOS costimulation in combination with CTLA-4 blockade remodels tumor-associated macrophages toward an antitumor phenotype	20
Identification of an anergic BND cell–derived activated B cell population (BND2) in young-onset type 1 diabetes patients	19
NLRP1 activation by UVB: Shedding light on an enigmatic inflammasome	19
Addendum: Protein arginine methyltransferase 1 regulates B cell fate after positive selection in the germinal center in mice	19
SARS-CoV-2 brainstem encephalitis in human inherited DBR1 deficiency	19
Secreted mammalian DNases protect against systemic bacterial infection by digesting biofilms	19
Sidestepping SHP2 inhibition	19
Helminths revive to survive	19
Transient inhibition of type I interferon enhances CD8+ T cell stemness and vaccine protection	19
Tissue-resident NK cells do their own glandscaping	19
Correction: Germinal center–dependent and –independent memory B cells produced throughout the immune response	19
cDC1-derived IL-27 regulates small intestinal CD4+ T cell homeostasis in mice	18
Antibody evolution to SARS-CoV-2 after single-dose Ad26.COV2.S vaccine in humans	18