Journal of Experimental Medicine

Article	Citations
Targeting potential drivers of COVID-19: Neutrophil extracellular traps	1098
SARS-CoV-2–triggered neutrophil extracellular traps mediate COVID-19 pathology	630
Neuroinvasion of SARS-CoV-2 in human and mouse brain	585
Inflammasomes are activated in response to SARS-CoV-2 infection and are associated with COVID-19 severity in patients	541
Measuring SARS-CoV-2 neutralizing antibody activity using pseudotyped and chimeric viruses	463
The many faces of the anti-COVID immune response	412
Lipid metabolism and cancer	337
Mouse model of SARS-CoV-2 reveals inflammatory role of type I interferon signaling	316
Ferroptosis in infection, inflammation, and immunity	296
Neutrophil extracellular traps infiltrate the lung airway, interstitial, and vascular compartments in severe COVID-19	267
Antibody potency, effector function, and combinations in protection and therapy for SARS-CoV-2 infection in vivo	253
Highly functional virus-specific cellular immune response in asymptomatic SARS-CoV-2 infection	251
Blood plasma phosphorylated-tau isoforms track CNS change in Alzheimer’s disease	239
Anti-human TREM2 induces microglia proliferation and reduces pathology in an Alzheimer’s disease model	219
Interleukin-17–induced neutrophil extracellular traps mediate resistance to checkpoint blockade in pancreatic cancer	216
Preexisting autoantibodies to type I IFNs underlie critical COVID-19 pneumonia in patients with APS-1	176
COVID-19 and emerging viral infections: The case for interferon lambda	166
Microglia in Alzheimer's disease at single-cell level. Are there common patterns in humans and mice?	148
PD-1 restraint of regulatory T cell suppressive activity is critical for immune tolerance	146
Phenotypical and functional alteration of unconventional T cells in severe COVID-19 patients	142
Accumulation of long-chain fatty acids in the tumor microenvironment drives dysfunction in intrapancreatic CD8+ T cells	139
Dynamic innate immune response determines susceptibility to SARS-CoV-2 infection and early replication kinetics	135
Mutations in COPA lead to abnormal trafficking of STING to the Golgi and interferon signaling	130
SHP2 inhibition diminishes KRASG12C cycling and promotes tumor microenvironment remodeling	130
Auto-antibodies to type I IFNs can underlie adverse reactions to yellow fever live attenuated vaccine	125

Multi-omic profiling reveals widespread dysregulation of innate immunity and hematopoiesis in COVID-19	123
Mapping and role of T cell response in SARS-CoV-2–infected mice	123
Analysis of classical neutrophils and polymorphonuclear myeloid-derived suppressor cells in cancer patients and tumor-bearing mice	122
Single-cell analysis of the cellular heterogeneity and interactions in the injured mouse spinal cord	121
Neutrophil phenotypes and functions in cancer: A consensus statement	119
Single-cell analysis of germinal-center B cells informs on lymphoma cell of origin and outcome	117
PKM2 promotes Th17 cell differentiation and autoimmune inflammation by fine-tuning STAT3 activation	114
Tumor-infiltrating dendritic cell states are conserved across solid human cancers	112
A defect in COPI-mediated transport of STING causes immune dysregulation in COPA syndrome	109
Inflammation as a regulator of hematopoietic stem cell function in disease, aging, and clonal selection	108
Type 1 conventional dendritic cells are systemically dysregulated early in pancreatic carcinogenesis	106
CD36, a signaling receptor and fatty acid transporter that regulates immune cell metabolism and fate	105
Historical overview of the interleukin-6 family cytokine	104
β-Catenin induces transcriptional expression of PD-L1 to promote glioblastoma immune evasion	102
Persistent cellular immunity to SARS-CoV-2 infection	102
SARS-CoV-2 induces human plasmacytoid predendritic cell diversification via UNC93B and IRAK4	98
Glutamine depletion regulates Slug to promote EMT and metastasis in pancreatic cancer	98
SARS-CoV-2–related MIS-C: A key to the viral and genetic causes of Kawasaki disease?	96
Macrophage morphology correlates with single-cell diversity and prognosis in colorectal liver metastasis	96
Glymphatic system clears extracellular tau and protects from tau aggregation and neurodegeneration	95
Phenotypic and functional characterization of first-trimester human placental macrophages, Hofbauer cells	94
Microglia modulate blood flow, neurovascular coupling, and hypoperfusion via purinergic actions	94
Activated microglia mitigate Aβ-associated tau seeding and spreading	93
Tissue-resident memory T cells in tumor immunity and immunotherapy	92
B cells and cancer: To B or not to B?	91
The mRNA m6A reader YTHDF2 suppresses proinflammatory pathways and sustains hematopoietic stem cell function	90
Innate immune pathways and inflammation in hematopoietic aging, clonal hematopoiesis, and MDS	89
Tumor-derived IL-6 and trans-signaling among tumor, fat, and muscle mediate pancreatic cancer cachexia	88
STING agonist promotes CAR T cell trafficking and persistence in breast cancer	87
APOBEC3A catalyzes mutation and drives carcinogenesis in vivo	84
Retrograde migration supplies resident memory T cells to lung-draining LN after influenza infection	81
Monocyte-derived macrophages promote breast cancer bone metastasis outgrowth	81
Dnmt3a-mutated clonal hematopoiesis promotes osteoporosis	81
The SIRPα–CD47 immune checkpoint in NK cells	78
The RNA m6A reader YTHDF2 controls NK cell antitumor and antiviral immunity	78
Single-cell RNA sequencing of murine islets shows high cellular complexity at all stages of autoimmune diabetes	77
Tissue-resident memory T cell reactivation by diverse antigen-presenting cells imparts distinct functional responses	75
Longevity and replenishment of human liver-resident memory T cells and mononuclear phagocytes	73
Single cell analysis of M. tuberculosis phenotype and macrophage lineages in the infected lung	72
Single-cell analyses identify circulating anti-tumor CD8 T cells and markers for their enrichment	72
Optimized gene engineering of murine CAR-T cells reveals the beneficial effects of IL-15 coexpression	72
Antigen-responsive CD4+ T cell clones contribute to the HIV-1 latent reservoir	71
Lung tumor MHCII immunity depends on in situ antigen presentation by fibroblasts	70
Sensing of endogenous nucleic acids by ZBP1 induces keratinocyte necroptosis and skin inflammation	70
Distinct functions of tissue-resident and circulating memory Th2 cells in allergic airway disease	69
A committed tissue-resident memory T cell precursor within the circulating CD8+ effector T cell pool	69
Single-cell analysis of human skin identifies CD14+ type 3 dendritic cells co-producing IL1B and IL23A in psoriasis	69
SARS-CoV-2 breakthrough infection in vaccinees induces virus-specific nasal-resident CD8+ and CD4+ T cells of broad specificity	68
TREM2-dependent lipid droplet biogenesis in phagocytes is required for remyelination	68
Brain transforms natural killer cells that exacerbate brain edema after intracerebral hemorrhage	68

Alveolar macrophages rely on GM-CSF from alveolar epithelial type 2 cells before and after birth	67
SOAT1 promotes mevalonate pathway dependency in pancreatic cancer	67
Mitophagy-mediated adipose inflammation contributes to type 2 diabetes with hepatic insulin resistance	66
Early nasal type I IFN immunity against SARS-CoV-2 is compromised in patients with autoantibodies against type I IFNs	66
Germinal center–dependent and –independent memory B cells produced throughout the immune response	65
TCR signal strength defines distinct mechanisms of T cell dysfunction and cancer evasion	63
Inhibition of macrophage histone demethylase JMJD3 protects against abdominal aortic aneurysms	63
Neuronal interleukin-1 receptors mediate pain in chronic inflammatory diseases	60
Necroptosis restricts influenza A virus as a stand-alone cell death mechanism	60
Anti-tumor immunity in mismatch repair-deficient colorectal cancers requires type I IFN–driven CCL5 and CXCL10	60
Autoantibody-mediated impairment of DNASE1L3 activity in sporadic systemic lupus erythematosus	60
Endothelial LRP1 protects against neurodegeneration by blocking cyclophilin A	58
HSV1 VP1-2 deubiquitinates STING to block type I interferon expression and promote brain infection	57
A TRPA1 inhibitor suppresses neurogenic inflammation and airway contraction for asthma treatment	56
Human autoantibodies underlying infectious diseases	56
Recessive inborn errors of type I IFN immunity in children with COVID-19 pneumonia	56
Intravenous administration of BCG protects mice against lethal SARS-CoV-2 challenge	56
TIM3+ TRBV11-2 T cells and IFNγ signature in patrolling monocytes and CD16+ NK cells delineate MIS-C	55
Sphingosine 1-phosphate receptor 5 (S1PR5) regulates the peripheral retention of tissue-resident lymphocytes	55
Conserved meningeal lymphatic drainage circuits in mice and humans	55
Lipocalin-2 counteracts metabolic dysregulation in obesity and diabetes	54
Mechanosensing through YAP controls T cell activation and metabolism	54
Immunogenicity and efficacy of one and two doses of Ad26.COV2.S COVID vaccine in adult and aged NHP	54
Anti–IFN-γ autoantibodies underlie disseminated Talaromyces marneffei infections	53
High microbiota reactivity of adult human intestinal IgA requires somatic mutations	53
Mitochondrial metabolism supports resistance to IDH mutant inhibitors in acute myeloid leukemia	52
The pleiotropic roles of leptin in metabolism, immunity, and cancer	52
Immune asynchrony in COVID-19 pathogenesis and potential immunotherapies	52
LILRB4 suppresses immunity in solid tumors and is a potential target for immunotherapy	51
Normalization of cholesterol metabolism in spinal microglia alleviates neuropathic pain	51
Distinct fibroblast functional states drive clinical outcomes in ovarian cancer and are regulated by TCF21	51
AIM2 controls microglial inflammation to prevent experimental autoimmune encephalomyelitis	51
Nicotine promotes brain metastasis by polarizing microglia and suppressing innate immune function	51
Type I interferon signaling mediates Mycobacterium tuberculosis–induced macrophage death	50
Functional immune cell–astrocyte interactions	50
Circulating clonally expanded T cells reflect functions of tumor-infiltrating T cells	48
α-Synuclein modulates tau spreading in mouse brains	48
Aged hematopoietic stem cells are refractory to bloodborne systemic rejuvenation interventions	48
Efficient gene knockout in primary human and murine myeloid cells by non-viral delivery of CRISPR-Cas9	47
Lipid-loaded tumor-associated macrophages sustain tumor growth and invasiveness in prostate cancer	47
NCKAP1L defects lead to a novel syndrome combining immunodeficiency, lymphoproliferation, and hyperinflammation	47
Exit from germinal center to become quiescent memory B cells depends on metabolic reprograming and provision of a survival signal	47
Human marginal zone B cell development from early T2 progenitors	47
Suppression of local type I interferon by gut microbiota–derived butyrate impairs antitumor effects of ionizing radiation	46
AKT-dependent NOTCH3 activation drives tumor progression in a model of mesenchymal colorectal cancer	46
Extracellular vesicle– and particle-mediated communication shapes innate and adaptive immune responses	46
Effects of dietary restriction on neuroinflammation in neurodegenerative diseases	46
Vi-specific serological correlates of protection for typhoid fever	46
PU.1 enforces quiescence and limits hematopoietic stem cell expansion during inflammatory stress	46
The GM-CSF–IRF5 signaling axis in eosinophils promotes antitumor immunity through activation of type 1 T cell responses	45
Single-cell lineage mapping of a diverse virus-specific naive CD4 T cell repertoire	45
Chronic TREM2 activation exacerbates Aβ-associated tau seeding and spreading	45
Limited rejuvenation of aged hematopoietic stem cells in young bone marrow niche	45
Membrane budding is a major mechanism of in vivo platelet biogenesis	45
Yolk sac, but not hematopoietic stem cell–derived progenitors, sustain erythropoiesis throughout murine embryonic life	44
Gut microbiota–driven brain Aβ amyloidosis in mice requires microglia	44
Lessons from Toxoplasma: Host responses that mediate parasite control and the microbial effectors that subvert them	44
A stem-loop RNA RIG-I agonist protects against acute and chronic SARS-CoV-2 infection in mice	43
A robust platform for expansion and genome editing of primary human natural killer cells	43
Plasmodium falciparum erythrocyte membrane protein 1 variants induce cell swelling and disrupt the blood–brain barrier in cerebral malaria	42
Inflammatory signaling regulates hematopoietic stem and progenitor cell development and homeostasis	42
SIRT1–NOX4 signaling axis regulates cancer cachexia	42
In vivo labeling reveals continuous trafficking of TCF-1+ T cells between tumor and lymphoid tissue	42
The architectural design of CD8+ T cell responses in acute and chronic infection: Parallel structures with divergent fates	41
Single-cell transcriptomic analysis of human colonic macrophages reveals niche-specific subsets	41
Intestinal epithelial tuft cell induction is negated by a murine helminth and its secreted products	41
Helicobacter pylori metabolites exacerbate gastritis through C-type lectin receptors	41
An NR2F1-specific agonist suppresses metastasis by inducing cancer cell dormancy	41
Activation of 4-1BBL+ B cells with CD40 agonism and IFNγ elicits potent immunity against glioblastoma	41
TGF-β and Eomes control the homeostasis of CD8+ regulatory T cells	40
Loss of decay-accelerating factor triggers podocyte injury and glomerulosclerosis	40
Neutrophils and COVID-19: Nots, NETs, and knots	40
BACH2 drives quiescence and maintenance of resting Treg cells to promote homeostasis and cancer immunosuppression	40
Preclinical validation of a potent γ-secretase modulator for Alzheimer’s disease prevention	39
Feeding-induced hepatokine, Manf, ameliorates diet-induced obesity by promoting adipose browning via p38 MAPK pathway	39
Plasmodium falciparum–specific IgM B cells dominate in children, expand with malaria, and produce functional IgM	39
Lineage-specific regulation of inducible and constitutive mast cells in allergic airway inflammation	39
Adiponectin restrains ILC2 activation by AMPK-mediated feedback inhibition of IL-33 signaling	38
Early type I IFN blockade improves the efficacy of viral vaccines	38
Blood transcriptomics reveal the evolution and resolution of the immune response in tuberculosis	38

Enhanced cGAS-STING–dependent interferon signaling associated with mutations in ATAD3A	38
Synaptic restoration by cAMP/PKA drives activity-dependent neuroprotection to motoneurons in ALS	38
Targeting CLK3 inhibits the progression of cholangiocarcinoma by reprogramming nucleotide metabolism	37
A Fas-4-1BB fusion protein converts a death to a pro-survival signal and enhances T cell therapy	37
Profiling HPV-16–specific T cell responses reveals broad antigen reactivities in oropharyngeal cancer patients	37
Gut microbiome stability and dynamics in healthy donors and patients with non-gastrointestinal cancers	37
MST4 kinase suppresses gastric tumorigenesis by limiting YAP activation via a non-canonical pathway	36
Rapid identification and characterization of infected cells in blood during chronic active Epstein-Barr virus infection	36
P38 kinases mediate NLRP1 inflammasome activation after ribotoxic stress response and virus infection	35
Autoantibodies against type I IFNs in patients with critical influenza pneumonia	35
Inhibition of ADAM17 impairs endothelial cell necroptosis and blocks metastasis	35
The T cell CD6 receptor operates a multitask signalosome with opposite functions in T cell activation	35
Reversal of emphysema by restoration of pulmonary endothelial cells	35
The current landscape of single-cell transcriptomics for cancer immunotherapy	35
Memory B cell responses to Omicron subvariants after SARS-CoV-2 mRNA breakthrough infection in humans	35
Multi-omic comparison of Alzheimer’s variants in human ESC–derived microglia reveals convergence at APOE	35
Upregulation of VCAM-1 in lymphatic collectors supports dendritic cell entry and rapid migration to lymph nodes in inflammation	35
Lysosomal cathepsin creates chimeric epitopes for diabetogenic CD4 T cells via transpeptidation	34
NLRC4 inflammasome activation is NLRP3- and phosphorylation-independent during infection and does not protect from melanoma	34
Integration features of intact latent HIV-1 in CD4+ T cell clones contribute to viral persistence	34
DNA damage contributes to neurotoxic inflammation in Aicardi-Goutières syndrome astrocytes	34
A high OXPHOS CD8 T cell subset is predictive of immunotherapy resistance in melanoma patients	34
Potent human broadly neutralizing antibodies to hepatitis B virus from natural controllers	34
The metabolism-modulating activity of IL-17 signaling in health and disease	34
Gut microbiota, NLR proteins, and intestinal homeostasis	34
Blocking inflammation on the way: Rationale for CXCR2 antagonists for the treatment of COVID-19	34
A growth factor–expressing macrophage subpopulation orchestrates regenerative inflammation via GDF-15	33
Modulating the quantity of HIV Env-specific CD4 T cell help promotes rare B cell responses in germinal centers	33
C-type lectin Mincle mediates cell death–triggered inflammation in acute kidney injury	33
Meteorin-like/Meteorin-β protects heart against cardiac dysfunction	33
Eosinophils are part of the granulocyte response in tuberculosis and promote host resistance in mice	33
Inflammasome signaling in human placental trophoblasts regulates immune defense against Listeria monocytogenes infection	33
TRIM24 facilitates antiviral immunity through mediating K63-linked TRAF3 ubiquitination	32
AIM2 regulates anti-tumor immunity and is a viable therapeutic target for melanoma	32
T reg cell–intrinsic requirements for ST2 signaling in health and neuroinflammation	32
CD4+ T cells in the lungs of acute sarcoidosis patients recognize an Aspergillus nidulans epitope	32
Suppressive effects of the obese tumor microenvironment on CD8 T cell infiltration and effector function	32
A human mutation in STAT3 promotes type 1 diabetes through a defect in CD8+ T cell tolerance	31
Diagnostic blood RNA profiles for human acute spinal cord injury	31
Life-threatening viral disease in a novel form of autosomal recessive IFNAR2 deficiency in the Arctic	31
Biochemically deleterious human NFKB1 variants underlie an autosomal dominant form of common variable immunodeficiency	31
The molecular and epigenetic mechanisms of innate lymphoid cell (ILC) memory and its relevance for asthma	31
T reg–specific insulin receptor deletion prevents diet-induced and age-associated metabolic syndrome	31
Characterization of human FDCs reveals regulation of T cells and antigen presentation to B cells	31
Potent human broadly SARS-CoV-2–neutralizing IgA and IgG antibodies effective against Omicron BA.1 and BA.2	31
High-efficiency nonviral CRISPR/Cas9-mediated gene editing of human T cells using plasmid donor DNA	31
Circadian immune circuits	31
Role of adipose tissue macrophages in obesity-related disorders	31
Human resident memory T cells exit the skin and mediate systemic Th2-driven inflammation	31
Constrained chromatin accessibility in PU.1-mutated agammaglobulinemia patients	31
Combined deletion of Bap1, Nf2, and Cdkn2ab causes rapid onset of malignant mesothelioma in mice	31
Cancer cell CCR2 orchestrates suppression of the adaptive immune response	31
PGD2 and CRTH2 counteract Type 2 cytokine–elicited intestinal epithelial responses during helminth infection	31
Cerebral cavernous malformations are driven by ADAMTS5 proteolysis of versican	30
CD4+ follicular regulatory T cells optimize the influenza virus–specific B cell response	30
PMN-derived netrin-1 attenuates cardiac ischemia-reperfusion injury via myeloid ADORA2B signaling	30
Reduced Ebola vaccine responses in CMV+ young adults is associated with expansion of CD57+KLRG1+ T cells	30
Sustained androgen receptor signaling is a determinant of melanoma cell growth potential and tumorigenesis	30
LYVE1+ macrophages of murine peritoneal mesothelium promote omentum-independent ovarian tumor growth	30
Critical requirement for BCR, BAFF, and BAFFR in memory B cell survival	30
Immunotherapy during the acute SHIV infection of macaques confers long-term suppression of viremia	30
BTK operates a phospho-tyrosine switch to regulate NLRP3 inflammasome activity	30
Chronic interleukin-1 exposure triggers selection for Cebpa-knockout multipotent hematopoietic progenitors	30
Activation of the integrated stress response confers vulnerability to mitoribosome-targeting antibiotics in melanoma	30
Molecular architecture determines brain delivery of a transferrin receptor–targeted lysosomal enzyme	30
Neutrophil-specific gain-of-function mutations in Nlrp3 promote development of cryopyrin-associated periodic syndrome	29
Genome-wide mutational signatures revealed distinct developmental paths for human B cell lymphomas	29
Cyclin D3 drives inertial cell cycling in dark zone germinal center B cells	29
Platelets orchestrate the resolution of pulmonary inflammation in mice by T reg cell repositioning and macrophage education	29
CD16+CD163+ monocytes traffic to sites of inflammation during necrotizing enterocolitis in premature infants	29
Group 2 innate lymphoid cells support hematopoietic recovery under stress conditions	29
Type I IFNs and CD8 T cells increase intestinal barrier permeability after chronic viral infection	29
Human germline heterozygous gain-of-functionSTAT6variants cause severe allergic disease	29
Clonal lineage tracing reveals mechanisms skewing CD8+ T cell fate decisions in chronic infection	29
Noncanonical STAT3 activity sustains pathogenic Th17 proliferation and cytokine response to antigen	29
Vincristine-induced peripheral neuropathy is driven by canonical NLRP3 activation and IL-1β release	29
Circulating tumor cells: Ready for translation?	29
Human STAT3 variants underlie autosomal dominant hyper-IgE syndrome by negative dominance	29
Layilin augments integrin activation to promote antitumor immunity	28
Serum HBsAg clearance has minimal impact on CD8+ T cell responses in mouse models of HBV infection	28
A loss-of-function IFNAR1 allele in Polynesia underlies severe viral diseases in homozygotes	28
A partial form of inherited human USP18 deficiency underlies infection and inflammation	28
Influenza infection fortifies local lymph nodes to promote lung-resident heterosubtypic immunity	28
Monocytes transition to macrophages within the inflamed vasculature via monocyte CCR2 and endothelial TNFR2	28
TGF-β regulates the stem-like state of PD-1+ TCF-1+ virus-specific CD8 T cells during chronic infection	28
Simultaneously targeting cancer-associated fibroblasts and angiogenic vessel as a treatment for TNBC	28
Constructing and deconstructing GATA2-regulated cell fate programs to establish developmental trajectories	28
Foxo1 controls gut homeostasis and commensalism by regulating mucus secretion	28
PRDM16 suppresses HIF-targeted gene expression in kidney cancer	27
Chronic viral infections persistently alter marrow stroma and impair hematopoietic stem cell fitness	27
Transmembrane TNF drives osteoproliferative joint inflammation reminiscent of human spondyloarthritis	27
Hypoxia-inducible factors individually facilitate inflammatory myeloid metabolism and inefficient cardiac repair	27
Elongated neutrophil-derived structures are blood-borne microparticles formed by rolling neutrophils during sepsis	27
The dark side of the gut: Virome–host interactions in intestinal homeostasis and disease	27
Treatment of two infants with PIK3CA-related overgrowth spectrum by alpelisib	27