Journal of Experimental Medicine

Article	Citations
Neuroinvasion of SARS-CoV-2 in human and mouse brain	655
Inflammasomes are activated in response to SARS-CoV-2 infection and are associated with COVID-19 severity in patients	576
Lipid metabolism and cancer	440
Ferroptosis in infection, inflammation, and immunity	380
Highly functional virus-specific cellular immune response in asymptomatic SARS-CoV-2 infection	270
Antibody potency, effector function, and combinations in protection and therapy for SARS-CoV-2 infection in vivo	267
Preexisting autoantibodies to type I IFNs underlie critical COVID-19 pneumonia in patients with APS-1	197
Microglia in Alzheimer's disease at single-cell level. Are there common patterns in humans and mice?	189
Neutrophil phenotypes and functions in cancer: A consensus statement	158
Dynamic innate immune response determines susceptibility to SARS-CoV-2 infection and early replication kinetics	152
Single-cell analysis of the cellular heterogeneity and interactions in the injured mouse spinal cord	150
CD36, a signaling receptor and fatty acid transporter that regulates immune cell metabolism and fate	149
Analysis of classical neutrophils and polymorphonuclear myeloid-derived suppressor cells in cancer patients and tumor-bearing mice	145
Auto-antibodies to type I IFNs can underlie adverse reactions to yellow fever live attenuated vaccine	144
Inflammation as a regulator of hematopoietic stem cell function in disease, aging, and clonal selection	140
Tumor-infiltrating dendritic cell states are conserved across solid human cancers	137
Mapping and role of T cell response in SARS-CoV-2–infected mice	137
Multi-omic profiling reveals widespread dysregulation of innate immunity and hematopoiesis in COVID-19	133
Glymphatic system clears extracellular tau and protects from tau aggregation and neurodegeneration	124
Activated microglia mitigate Aβ-associated tau seeding and spreading	116
Microglia modulate blood flow, neurovascular coupling, and hypoperfusion via purinergic actions	114
B cells and cancer: To B or not to B?	112
Tissue-resident memory T cells in tumor immunity and immunotherapy	111
Innate immune pathways and inflammation in hematopoietic aging, clonal hematopoiesis, and MDS	109
SARS-CoV-2 induces human plasmacytoid predendritic cell diversification via UNC93B and IRAK4	107

Persistent cellular immunity to SARS-CoV-2 infection	107
STING agonist promotes CAR T cell trafficking and persistence in breast cancer	107
SARS-CoV-2–related MIS-C: A key to the viral and genetic causes of Kawasaki disease?	107
Tumor-derived IL-6 and trans-signaling among tumor, fat, and muscle mediate pancreatic cancer cachexia	106
The mRNA m6A reader YTHDF2 suppresses proinflammatory pathways and sustains hematopoietic stem cell function	103
The SIRPα–CD47 immune checkpoint in NK cells	101
The RNA m6A reader YTHDF2 controls NK cell antitumor and antiviral immunity	98
Dnmt3a-mutated clonal hematopoiesis promotes osteoporosis	98
Single cell analysis of M. tuberculosis phenotype and macrophage lineages in the infected lung	93
Optimized gene engineering of murine CAR-T cells reveals the beneficial effects of IL-15 coexpression	93
Single-cell analysis of human skin identifies CD14+ type 3 dendritic cells co-producing IL1B and IL23A in psoriasis	89
Lung tumor MHCII immunity depends on in situ antigen presentation by fibroblasts	87
TREM2-dependent lipid droplet biogenesis in phagocytes is required for remyelination	85
Alveolar macrophages rely on GM-CSF from alveolar epithelial type 2 cells before and after birth	83
TCR signal strength defines distinct mechanisms of T cell dysfunction and cancer evasion	83
SARS-CoV-2 breakthrough infection in vaccinees induces virus-specific nasal-resident CD8+ and CD4+ T cells of broad specificity	83
Single-cell analyses identify circulating anti-tumor CD8 T cells and markers for their enrichment	81
Mitophagy-mediated adipose inflammation contributes to type 2 diabetes with hepatic insulin resistance	80
Autoantibody-mediated impairment of DNASE1L3 activity in sporadic systemic lupus erythematosus	78
Inhibition of macrophage histone demethylase JMJD3 protects against abdominal aortic aneurysms	77
Conserved meningeal lymphatic drainage circuits in mice and humans	75
A TRPA1 inhibitor suppresses neurogenic inflammation and airway contraction for asthma treatment	75
Germinal center–dependent and –independent memory B cells produced throughout the immune response	71
Lipid-loaded tumor-associated macrophages sustain tumor growth and invasiveness in prostate cancer	71
Early nasal type I IFN immunity against SARS-CoV-2 is compromised in patients with autoantibodies against type I IFNs	71
Recessive inborn errors of type I IFN immunity in children with COVID-19 pneumonia	70
Human autoantibodies underlying infectious diseases	70
Endothelial LRP1 protects against neurodegeneration by blocking cyclophilin A	70
Anti-tumor immunity in mismatch repair-deficient colorectal cancers requires type I IFN–driven CCL5 and CXCL10	68
Intravenous administration of BCG protects mice against lethal SARS-CoV-2 challenge	66
Chronic TREM2 activation exacerbates Aβ-associated tau seeding and spreading	66
In vivo labeling reveals continuous trafficking of TCF-1+ T cells between tumor and lymphoid tissue	65
Sphingosine 1-phosphate receptor 5 (S1PR5) regulates the peripheral retention of tissue-resident lymphocytes	64
TIM3+ TRBV11-2 T cells and IFNγ signature in patrolling monocytes and CD16+ NK cells delineate MIS-C	64
LILRB4 suppresses immunity in solid tumors and is a potential target for immunotherapy	63
Aged hematopoietic stem cells are refractory to bloodborne systemic rejuvenation interventions	63
Mitochondrial metabolism supports resistance to IDH mutant inhibitors in acute myeloid leukemia	62
AIM2 controls microglial inflammation to prevent experimental autoimmune encephalomyelitis	62
Effects of dietary restriction on neuroinflammation in neurodegenerative diseases	62
Immunogenicity and efficacy of one and two doses of Ad26.COV2.S COVID vaccine in adult and aged NHP	61
The pleiotropic roles of leptin in metabolism, immunity, and cancer	61
Suppression of local type I interferon by gut microbiota–derived butyrate impairs antitumor effects of ionizing radiation	60
Normalization of cholesterol metabolism in spinal microglia alleviates neuropathic pain	59
Inflammatory signaling regulates hematopoietic stem and progenitor cell development and homeostasis	59
Functional immune cell–astrocyte interactions	58
Extracellular vesicle– and particle-mediated communication shapes innate and adaptive immune responses	56
Human marginal zone B cell development from early T2 progenitors	55
Limited rejuvenation of aged hematopoietic stem cells in young bone marrow niche	55
A stem-loop RNA RIG-I agonist protects against acute and chronic SARS-CoV-2 infection in mice	54
PU.1 enforces quiescence and limits hematopoietic stem cell expansion during inflammatory stress	52

Autoantibodies against type I IFNs in patients with critical influenza pneumonia	52
Gut microbiota–driven brain Aβ amyloidosis in mice requires microglia	52
Circulating clonally expanded T cells reflect functions of tumor-infiltrating T cells	51
Yolk sac, but not hematopoietic stem cell–derived progenitors, sustain erythropoiesis throughout murine embryonic life	50
Eosinophils are part of the granulocyte response in tuberculosis and promote host resistance in mice	49
Vi-specific serological correlates of protection for typhoid fever	49
The architectural design of CD8+ T cell responses in acute and chronic infection: Parallel structures with divergent fates	49
Single-cell lineage mapping of a diverse virus-specific naive CD4 T cell repertoire	49
Life-threatening viral disease in a novel form of autosomal recessive IFNAR2 deficiency in the Arctic	48
Preclinical validation of a potent γ-secretase modulator for Alzheimer’s disease prevention	48
DNA damage contributes to neurotoxic inflammation in Aicardi-Goutières syndrome astrocytes	48
An NR2F1-specific agonist suppresses metastasis by inducing cancer cell dormancy	48
Lessons from Toxoplasma: Host responses that mediate parasite control and the microbial effectors that subvert them	47
A robust platform for expansion and genome editing of primary human natural killer cells	47
Plasmodium falciparum–specific IgM B cells dominate in children, expand with malaria, and produce functional IgM	47
Feeding-induced hepatokine, Manf, ameliorates diet-induced obesity by promoting adipose browning via p38 MAPK pathway	47
P38 kinases mediate NLRP1 inflammasome activation after ribotoxic stress response and virus infection	47
Plasmodium falciparum erythrocyte membrane protein 1 variants induce cell swelling and disrupt the blood–brain barrier in cerebral malaria	47
Single-cell transcriptomic analysis of human colonic macrophages reveals niche-specific subsets	46
Enhanced cGAS-STING–dependent interferon signaling associated with mutations in ATAD3A	46
Reversal of emphysema by restoration of pulmonary endothelial cells	46
The metabolism-modulating activity of IL-17 signaling in health and disease	46
Blood transcriptomics reveal the evolution and resolution of the immune response in tuberculosis	46
Gut microbiome stability and dynamics in healthy donors and patients with non-gastrointestinal cancers	45
Intestinal epithelial tuft cell induction is negated by a murine helminth and its secreted products	44
High-efficiency nonviral CRISPR/Cas9-mediated gene editing of human T cells using plasmid donor DNA	44
TGF-β regulates the stem-like state of PD-1+ TCF-1+ virus-specific CD8 T cells during chronic infection	42
The current landscape of single-cell transcriptomics for cancer immunotherapy	42
A growth factor–expressing macrophage subpopulation orchestrates regenerative inflammation via GDF-15	42
A high OXPHOS CD8 T cell subset is predictive of immunotherapy resistance in melanoma patients	41
Inhibition of ADAM17 impairs endothelial cell necroptosis and blocks metastasis	41
Potent human broadly SARS-CoV-2–neutralizing IgA and IgG antibodies effective against Omicron BA.1 and BA.2	40
A partial form of inherited human USP18 deficiency underlies infection and inflammation	40
Human resident memory T cells exit the skin and mediate systemic Th2-driven inflammation	40
Suppressive effects of the obese tumor microenvironment on CD8 T cell infiltration and effector function	40
CD4+ T cells in the lungs of acute sarcoidosis patients recognize an Aspergillus nidulans epitope	40
Meteorin-like/Meteorin-β protects heart against cardiac dysfunction	40
Memory B cell responses to Omicron subvariants after SARS-CoV-2 mRNA breakthrough infection in humans	39
Integration features of intact latent HIV-1 in CD4+ T cell clones contribute to viral persistence	39
Hypoxia-inducible factors individually facilitate inflammatory myeloid metabolism and inefficient cardiac repair	39
Characterization of human FDCs reveals regulation of T cells and antigen presentation to B cells	39
Treatment of two infants with PIK3CA-related overgrowth spectrum by alpelisib	38
A human mutation in STAT3 promotes type 1 diabetes through a defect in CD8+ T cell tolerance	38
Monocytes transition to macrophages within the inflamed vasculature via monocyte CCR2 and endothelial TNFR2	38
Diagnostic blood RNA profiles for human acute spinal cord injury	38
The aryl hydrocarbon receptor contributes to tissue adaptation of intestinal eosinophils in mice	38
Molecular architecture determines brain delivery of a transferrin receptor–targeted lysosomal enzyme	38
Upregulation of VCAM-1 in lymphatic collectors supports dendritic cell entry and rapid migration to lymph nodes in inflammation	38
Constrained chromatin accessibility in PU.1-mutated agammaglobulinemia patients	37
Circadian immune circuits	37
PGD2 and CRTH2 counteract Type 2 cytokine–elicited intestinal epithelial responses during helminth infection	37
The molecular and epigenetic mechanisms of innate lymphoid cell (ILC) memory and its relevance for asthma	37
A loss-of-function IFNAR1 allele in Polynesia underlies severe viral diseases in homozygotes	37
Clonal lineage tracing reveals mechanisms skewing CD8+ T cell fate decisions in chronic infection	37
LYVE1+ macrophages of murine peritoneal mesothelium promote omentum-independent ovarian tumor growth	37
Modulating the quantity of HIV Env-specific CD4 T cell help promotes rare B cell responses in germinal centers	37
Elevating microglia TREM2 reduces amyloid seeding and suppresses disease-associated microglia	36
GPX4 regulates cellular necrosis and host resistance in Mycobacterium tuberculosis infection	36
CD4+ T helper 2 cells suppress breast cancer by inducing terminal differentiation	36
Role of adipose tissue macrophages in obesity-related disorders	36
Arachnoid granulations are lymphatic conduits that communicate with bone marrow and dura-arachnoid stroma	36
CD4+ follicular regulatory T cells optimize the influenza virus–specific B cell response	36
Chronic interleukin-1 exposure triggers selection for Cebpa-knockout multipotent hematopoietic progenitors	36
Human germline heterozygous gain-of-functionSTAT6variants cause severe allergic disease	36
AIM2 regulates anti-tumor immunity and is a viable therapeutic target for melanoma	35
Hepatic stellate and endothelial cells maintain hematopoietic stem cells in the developing liver	35
Platelets orchestrate the resolution of pulmonary inflammation in mice by T reg cell repositioning and macrophage education	35
Group 2 innate lymphoid cells support hematopoietic recovery under stress conditions	35
Neutrophil extracellular traps and extracellular histones potentiate IL-17 inflammation in periodontitis	35
Synaptic pruning of murine adult-born neurons by microglia depends on phosphatidylserine	35
Biochemically deleterious human NFKB1 variants underlie an autosomal dominant form of common variable immunodeficiency	35
PMN-derived netrin-1 attenuates cardiac ischemia-reperfusion injury via myeloid ADORA2B signaling	34
Immune checkpoint inhibitors	34
Altered glycosylation in pancreatic cancer and beyond	34
Cyclin D3 drives inertial cell cycling in dark zone germinal center B cells	34
BTK operates a phospho-tyrosine switch to regulate NLRP3 inflammasome activity	34
Sleep exerts lasting effects on hematopoietic stem cell function and diversity	34
Foxo1 controls gut homeostasis and commensalism by regulating mucus secretion	34
Matrix compliance permits NF-κB activation to drive therapy resistance in breast cancer	34
STAT3 regulates CD8+ T cell differentiation and functions in cancer and acute infection	34

Vincristine-induced peripheral neuropathy is driven by canonical NLRP3 activation and IL-1β release	33
Impaired IL-23–dependent induction of IFN-γ underlies mycobacterial disease in patients with inherited TYK2 deficiency	33
Activation of the integrated stress response confers vulnerability to mitoribosome-targeting antibiotics in melanoma	33
CD127 imprints functional heterogeneity to diversify monocyte responses in inflammatory diseases	33
Genome-wide mutational signatures revealed distinct developmental paths for human B cell lymphomas	33
Autoantibodies neutralizing type I IFNs underlie West Nile virus encephalitis in ∼40% of patients	33
Human STAT3 variants underlie autosomal dominant hyper-IgE syndrome by negative dominance	33
Simultaneously targeting cancer-associated fibroblasts and angiogenic vessel as a treatment for TNBC	33
Interplay of vascular endothelial growth factor receptors in organ-specific vessel maintenance	33
Modeling human yolk sac hematopoiesis with pluripotent stem cells	33
Neutrophil-specific gain-of-function mutations in Nlrp3 promote development of cryopyrin-associated periodic syndrome	32
Broad and potent neutralizing human antibodies to tick-borne flaviviruses protect mice from disease	32
Adoptive cell therapy: Living drugs against cancer	32
CCL5-producing migratory dendritic cells guide CCR5+ monocytes into the draining lymph nodes	32
Microbiota and adipocyte mitochondrial damage in type 2 diabetes are linked by Mmp12+ macrophages	32
CD47 blockade enhances the efficacy of intratumoral STING-targeting therapy by activating phagocytes	31
The dark side of the gut: Virome–host interactions in intestinal homeostasis and disease	31
Chronic T cell proliferation in brains after stroke could interfere with the efficacy of immunotherapies	31
Age-associated B cells are heterogeneous and dynamic drivers of autoimmunity in mice	31
Human NLRP1: From the shadows to center stage	31
WNT signaling in the tumor microenvironment promotes immunosuppression in murine pancreatic cancer	31
A “multi-omics” analysis of blood–brain barrier and synaptic dysfunction in APOE4 mice	31
CD16+CD163+ monocytes traffic to sites of inflammation during necrotizing enterocolitis in premature infants	31
Engineering an inhibitor-resistant human CSF1R variant for microglia replacement	30
WEE1 inhibition induces anti-tumor immunity by activating ERV and the dsRNA pathway	30
ASC deglutathionylation is a checkpoint for NLRP3 inflammasome activation	30
The long noncoding RNA Malat1 regulates CD8+ T cell differentiation by mediating epigenetic repression	30
CCR2/CCR5 inhibitor permits the radiation-induced effector T cell infiltration in pancreatic adenocarcinoma	30
The transcription factor HIF-1α mediates plasticity of NKp46+ innate lymphoid cells in the gut	30
Broader Epstein–Barr virus–specific T cell receptor repertoire in patients with multiple sclerosis	30
Ly49E separates liver ILC1s into embryo-derived and postnatal subsets with different functions	30
Vision rescue via unconstrained in vivo prime editing in degenerating neural retinas	30
Impaired immune response drives age-dependent severity of COVID-19	30
NK/ILC1 cells mediate neuroinflammation and brain pathology following congenital CMV infection	29
GIMAP5 maintains liver endothelial cell homeostasis and prevents portal hypertension	29
Chronic viral infections persistently alter marrow stroma and impair hematopoietic stem cell fitness	29
Immunodominant antibody germlines in COVID-19	29
Identification of conserved SARS-CoV-2 spike epitopes that expand public cTfh clonotypes in mild COVID-19 patients	29
Maternal gut microbiome regulates immunity to RSV infection in offspring	29
CD116+ fetal precursors migrate to the perinatal lung and give rise to human alveolar macrophages	29
Targeting mechanosensitive MDM4 promotes lung fibrosis resolution in aged mice	29
Antibodies against human endogenous retrovirus K102 envelope activate neutrophils in systemic lupus erythematosus	29
CD1a selectively captures endogenous cellular lipids that broadly block T cell response	29
A dysregulated sebum–microbial metabolite–IL-33 axis initiates skin inflammation in atopic dermatitis	29
Systematic memory B cell archiving and random display shape the human splenic marginal zone throughout life	29
Macrophages promote anti-androgen resistance in prostate cancer bone disease	28
Diminished cell proliferation promotes natural killer cell adaptive-like phenotype by limiting FcεRIγ expression	28
Augmenting neurogenesis rescues memory impairments in Alzheimer’s disease by restoring the memory-storing neurons	28
Elongated neutrophil-derived structures are blood-borne microparticles formed by rolling neutrophils during sepsis	28
High Th2 cytokine levels and upper airway inflammation in human inherited T-bet deficiency	27
The germinal center reaction depends on RNA methylation and divergent functions of specific methyl readers	27
Multimeric antibodies from antigen-specific human IgM+ memory B cells restrict Plasmodium parasites	27
Intestinal toxicity to CTLA-4 blockade driven by IL-6 and myeloid infiltration	27
T helper 2 cells in asthma	27
PD-1 and TIM-3 differentially regulate subsets of mouse IL-17A–producing γδ T cells	27
STING trafficking as a new dimension of immune signaling	27
Heterogeneous disease-propagating stem cells in juvenile myelomonocytic leukemia	27
Stunning of neutrophils accounts for the anti-inflammatory effects of clodronate liposomes	27
Single-cell analyses reveal early thymic progenitors and pre-B cells in zebrafish	26
IFN-γ signature enables selection of neoadjuvant treatment in patients with stage III melanoma	26
PPARγ is essential for the development of bone marrow erythroblastic island macrophages and splenic red pulp macrophages	26
A distinct CD38+CD45RA+ population of CD4+, CD8+, and double-negative T cells is controlled by FAS	26
TBK1 recruitment to STING mediates autoinflammatory arthritis caused by defective DNA clearance	26
Regulation of the alveolar regenerative niche by amphiregulin-producing regulatory T cells	26
Understanding adverse events of immunotherapy: A mechanistic perspective	26
Realigning the LIGHT signaling network to control dysregulated inflammation	26
E3 ligase MKRN3 is a tumor suppressor regulating PABPC1 ubiquitination in non–small cell lung cancer	26
Vitamin B12 coordinates ileal epithelial cell and microbiota functions to resist Salmonella infection in mice	26
IL-17–induced HIF1α drives resistance to anti–PD-L1 via fibroblast-mediated immune exclusion	25
Infection-induced lymphatic zippering restricts fluid transport and viral dissemination from skin	25
Bhlhe40 function in activated B and TFH cells restrains the GC reaction and prevents lymphomagenesis	25
Landscape of mast cell populations across organs in mice and humans	25
DCs at the center of help: Origins and evolution of the three-cell-type hypothesis	25
The X in seX-biased immunity and autoimmune rheumatic disease	25
Single-cell immune profiling reveals functional diversity of T cells in tuberculous pleural effusion	25
Trapping of CDC42 C-terminal variants in the Golgi drives pyrin inflammasome hyperactivation	25
Impaired respiratory burst contributes to infections in PKCδ-deficient patients	25
Modulation of tissue resident memory T cells by glucocorticoids after acute cellular rejection in lung transplantation	25
Human type I IFN deficiency does not impair B cell response to SARS-CoV-2 mRNA vaccination	24
P2RY8 variants in lupus patients uncover a role for the receptor in immunological tolerance	24
Engrailed 1 coordinates cytoskeletal reorganization to induce myofibroblast differentiation	24
Progressive differentiation toward the long-lived plasma cell compartment in the bone marrow	24
Germline SAMD9L truncation variants trigger global translational repression	24
Chronic activation of pDCs in autoimmunity is linked to dysregulated ER stress and metabolic responses	24
T and B cell abnormalities, pneumocystis pneumonia, and chronic lymphocytic leukemia associated with an AIOLOS defect in patients	24
Neural control of immune cell trafficking	24
Age-related alterations in meningeal immunity drive impaired CNS lymphatic drainage	24
Arkadia-SKI/SnoN signaling differentially regulates TGF-β–induced iTreg and Th17 cell differentiation	23
TIMP1 expression underlies sex disparity in liver metastasis and survival in pancreatic cancer	23
Nuclear DEK preserves hematopoietic stem cells potential via NCoR1/HDAC3-Akt1/2-mTOR axis	23
Antibody feedback contributes to facilitating the development of Omicron-reactive memory B cells in SARS-CoV-2 mRNA vaccinees	23
Macroautophagy in lymphatic endothelial cells inhibits T cell–mediated autoimmunity	23
Transient astrocytic mGluR5 expression drives synaptic plasticity and subsequent chronic pain in mice	23
Differential IL-12 signaling induces human natural killer cell activating receptor-mediated ligand-specific expansion	22
Familial thrombocytopenia due to a complex structural variant resulting in a WAC-ANKRD26 fusion transcript	22