Journal of Experimental Medicine

Article	Citations
S1PR1, an endothelial-immune influencer	307
ALK2/3 recruitment to the immunological synapse is required for T cell activation and death	252
Host factor TIMP1 sustains long-lasting myeloid-biased hematopoiesis after severe infection	196
Prenatally derived macrophages support choroidal health and decline in age-related macular degeneration	189
Antibody feedback contributes to facilitating the development of Omicron-reactive memory B cells in SARS-CoV-2 mRNA vaccinees	149
Intestinal epithelial c-Maf expression determines enterocyte differentiation and nutrient uptake in mice	133
The pathogenic role of retinoid nuclear receptor signaling in cancer and metabolic syndromes	132
Antigen-independent, autonomous B cell receptor signaling drives activated B cell DLBCL	123
RORγt eTACs mediate oral tolerance and Treg induction	116
Protection of ischemic white matter and oligodendrocytes in mice by 3K3A-activated protein C	108
Early innate role for CD8αα+ cells in tuberculosis	103
Primary tumor–derived systemic nANGPTL4 inhibits metastasis	101
Differential IL-12 signaling induces human natural killer cell activating receptor-mediated ligand-specific expansion	101
Neutralizing antibodies protect mice against Venezuelan equine encephalitis virus aerosol challenge	98
Epitope and HLA specificity of human TCRs against Plasmodium falciparum circumsporozoite protein	93
Inhibition of astrocytic DRD2 suppresses CNS inflammation in an animal model of multiple sclerosis	91
High burden of viruses and bacterial pathobionts drives heightened nasal innate immunity in children	89
Common cold embecovirus imprinting primes broadly neutralizing antibody responses to SARS-CoV-2 S2	88
SARS-CoV-2 Spike protein suppresses CTL-mediated killing by inhibiting immune synapse assembly	88
TCR signal strength defines distinct mechanisms of T cell dysfunction and cancer evasion	86
An iron-rich subset of macrophages promotes tumor growth through a Bach1-Ednrb axis	82
B cell receptor ligation induces IgE plasma cell elimination	81
IL-21 shapes germinal center polarization via light zone B cell selection and cyclin D3 upregulation	80
pDCs, type 1 IFN, and the female predileXion of SSc	79
IFNγ score–based neoadjuvant immunotherapy for stage III melanoma	78

Lymphatic chain gradients regulate the magnitude and heterogeneity of T cell responses to vaccination	77
Correction: ICAM-1 controls development and function of ILC2	77
Making memories with Bcl-6	76
CD8+ T cell depletion prevents neuropathology in a mouse model of globoid cell leukodystrophy	73
Transit-amplifying cells control R-spondins in the mouse crypt to modulate intestinal stem cell proliferation	71
Correction: Segmented filamentous bacteria–induced epithelial MHCII regulates cognate CD4+ IELs and epithelial turnover	71
A human STAT3 gain-of-function variant drives local Th17 dysregulation and skin inflammation in mice	70
Non-professional efferocytosis of Salmonella-infected intestinal epithelial cells in the neonatal host	68
Loss of ATG7 in microglia impairs UPR, triggers ferroptosis, and weakens amyloid pathology control	68
Dual role of vascular endothelial growth factor-C in post-stroke recovery	68
CXCL12+ dermal fibroblasts promote neutrophil recruitment and host defense by recognition of IL-17	68
Heterozygous human JAK2V617F activates AhR to drive essential thrombocythemia and promote thrombosis	68
TIGIT mediates activation-induced cell death of ILC2s during chronic airway allergy	68
NFAT5 governs cellular plasticity-driven resistance to KRAS-targeted therapy in pancreatic cancer	67
The genetic background shapes the susceptibility to mitochondrial dysfunction and NASH progression	67
Challenges in TB research	67
Systems-level conservation of the proximal TCR signaling network of mice and humans	66
A high OXPHOS CD8 T cell subset is predictive of immunotherapy resistance in melanoma patients	65
Hypoxia induces adrenomedullin from lung epithelia, stimulating ILC2 inflammation and immunity	64
Obesity alters monocyte developmental trajectories to enhance metastasis	63
Role of adipose tissue macrophages in obesity-related disorders	63
Somatic gain-of-function mutations in BUD13 promote oncogenesis by disrupting Fbw7 function	62
How decreasing T cell signaling unexpectedly results in autoimmunity	62
Michelle Linterman: We are always learning	61
Nina Cabezas Wallscheid: Enjoying the freedom to decide my research path	60
Tingible body macrophages: Gargantuan chameleons of the germinal center	60
MYO1F in neutrophils is required for the response to immune checkpoint blockade therapy	60
A twist in the tail: Of T cell subsets and disease	59
Promiscuous recognition of MR1 drives self-reactive mucosal-associated invariant T cell responses	58
CD150-dependent hematopoietic stem cell sensing of Brucella instructs myeloid commitment	58
Targeting infection-specific peptides in immunopeptidomics studies for vaccine target discovery	58
Protective fibroblastic niches in secondary lymphoid organs	57
Pleiotrophin drives a prometastatic immune niche in breast cancer	57
Immunomolecular and reactivity landscapes of gut IgA subclasses in homeostasis and inflammatory bowel disease	57
Amino acid availability acts as a metabolic rheostat to determine the magnitude of ILC2 responses	56
IEC-intrinsic IL-1R signaling holds dual roles in regulating intestinal homeostasis and inflammation	56
MYC is a clinically significant driver of mTOR inhibitor resistance in breast cancer	55
Oral antigen exposure under costimulation blockade induces Treg cells to establish immune tolerance	55
Inherited human ITK deficiency impairs IFN-γ immunity and underlies tuberculosis	54
Dietary intervention preserves β cell function in mice through CTCF-mediated transcriptional reprogramming	54
Deficiency for SAMHD1 activates MDA5 in a cGAS/STING-dependent manner	53
Spatiotemporal dynamics of fetal liver hematopoietic niches	53
CXCR4+ Treg cells control serum IgM levels and natural IgM autoantibody production by B-1 cells in the bone marrow	52
Functional specialization of short-lived and long-lived macrophage subsets in human tonsils	52
Augmenting neurogenesis rescues memory impairments in Alzheimer’s disease by restoring the memory-storing neurons	52
Protein arginine methyltransferase 1 regulates B cell fate after positive selection in the germinal center in mice	52
Altered glycosylation in pancreatic cancer and beyond	51
Memory B cell responses to Omicron subvariants after SARS-CoV-2 mRNA breakthrough infection in humans	51
Ki67 deficiency impedes chromatin accessibility and BCR gene rearrangement	50
Correction: Role of affinity in plasma cell development in the germinal center light zone	50

Human autoantibodies underlying infectious diseases	50
CTLA4 prohibits T cells from cross-dressing	49
Targeting neuroinflammation in neuropathic pain and opioid use	49
Changing behind the scenes	49
Sara Suliman: Science is better when it’s shared	49
Correction: Chromatin landscapes reveal developmentally encoded transcriptional states that define human glioblastoma	49
NK cell expansion requires HuR and mediates control of solid tumors and long-term virus infection	48
Immature B cell homing shapes human lymphoid tissue structure and function	48
CD4+ T cell dysfunction in cancer	48
Correction: SCFβ-TRCP suppresses angiogenesis and thyroid cancer cell migration by promoting ubiquitination and destruction of VEGF receptor 2	48
Correction: Mouse model of SARS-CoV-2 reveals inflammatory role of type I interferon signaling	48
Tumor-derived OBP2A promotes prostate cancer castration resistance	47
Activating NO–sGC crosstalk in the mouse vascular niche promotes vascular integrity and mitigates acute lung injury	47
DNA damage contributes to neurotoxic inflammation in Aicardi-Goutières syndrome astrocytes	47
Functional vulnerability of liver macrophages to capsules defines virulence of blood-borne bacteria	46
Regulatory T cells converted from Th1 cells in tumors suppress cancer immunity via CD39	46
Hnf4 activates mimetic-cell enhancers to recapitulate gut and liver development within the thymus	46
Gain-of-function human UNC93B1 variants cause systemic lupus erythematosus and chilblain lupus	45
TCR signaling induces STAT3 phosphorylation to promote TH17 cell differentiation	44
Differential impact of lymphatic outflow pathways on cerebrospinal fluid homeostasis	44
The common HAQ STING allele prevents clinical penetrance of COPA syndrome	44
Synaptic pruning of murine adult-born neurons by microglia depends on phosphatidylserine	44
TET2–STAT3–CXCL5 nexus promotes neutrophil lipid transfer to fuel lung adeno-to-squamous transition	43
Altered X-chromosome inactivation of the TLR7/8 locus and heterogeneity of pDCs in systemic sclerosis	43
Transient astrocytic mGluR5 expression drives synaptic plasticity and subsequent chronic pain in mice	43
CAR-T cell manufacturing: Major process parameters and next-generation strategies	43
Macrophages in the synovial lining niche initiate neutrophil recruitment and articular inflammation	43
Perfecting antigen prediction	42
Correction: Antigen-presenting autoreactive B cells activate regulatory T cells and suppress autoimmune arthritis in mice	42
Correction: Context-dependent effects of IL-2 rewire immunity into distinct cellular circuits	42
Correction: Precursor central memory versus effector cell fate and naïve CD4+ T cell heterogeneity	42
Women in STEM becoming independent: The journey to independence is an immensely gratifying odyssey	41
Laura Mackay: Don't be afraid to engage	41
A cell-free antigen processing system informs HIV-1 epitope selection and vaccine design	40
Correction: Profiling HPV-16–specific T cell responses reveals broad antigen reactivities in oropharyngeal cancer patients	40
Addendum: Resolvins suppress tumor growth and enhance cancer therapy	40
Loss of ARID3A perturbs intestinal epithelial proliferation–differentiation ratio and regeneration	39
Neonatal microbiota colonization primes maturation of goblet cell–mediated protection in the pre-weaning colon	39
Disruption of thymic central tolerance by infection with murine roseolovirus induces autoimmune gastritis	39
Dynamic Foxp3–chromatin interaction controls tunable Treg cell function	38
Hemifacial myohyperplasia is due to somatic muscular PIK3CA gain-of-function mutations and responds to pharmacological inhibition	37
A path forward for Staphylococcus aureus vaccine development	37
Intestinal epithelial tuft cell induction is negated by a murine helminth and its secreted products	37
Coxsackievirus A10 impairs nail regeneration and induces onychomadesis by mimicking DKK1 to attenuate Wnt signaling	37
Trapping of CDC42 C-terminal variants in the Golgi drives pyrin inflammasome hyperactivation	37
Competitive fungal commensalism mitigates candidiasis pathology	36
Age- and diet-instructed metabolic rewiring of the tumor–immune microenvironment	36
Succinate-producing microbiota drives tuft cell hyperplasia to protect against Clostridioides difficile	36
Intravital imaging of pulmonary lymphatics in inflammation and metastatic cancer	36
CD163+ macrophages monitor enhanced permeability at the blood–dorsal root ganglion barrier	36
Distinct fibroblast progenitor subpopulation expedites regenerative mucosal healing by immunomodulation	36
Vision rescue via unconstrained in vivo prime editing in degenerating neural retinas	35
Chronic activation of pDCs in autoimmunity is linked to dysregulated ER stress and metabolic responses	35
Dominant negative OTULIN-related autoinflammatory syndrome	35
Cigarette smoke components modulate the MR1–MAIT axis	35
Membrane-IL12 adjuvant mRNA vaccine polarizes pre-effector T cells for optimized tumor control	34
Inhibitory pattern recognition receptors	34
HMCN1 variants aggravate epidermolysis bullosa simplex phenotype	34
Trav15-dv6 family Tcrd rearrangements diversify the Tcra repertoire	34
CD4+ T helper 2 cells suppress breast cancer by inducing terminal differentiation	34
RAC2 gain-of-function variants causing inborn error of immunity drive NLRP3 inflammasome activation	33
RIPK1 S161 phosphorylation promotes further autophosphorylation and cecal necroptosis in TNF-treated mice	33
Nucleotide modifications enable rational design of TLR7-selective ligands by blocking RNase cleavage	33
Repurposing a tricyclic antidepressant in tumor and metabolism disease treatment through fatty acid uptake inhibition	33
Stalled but not forgotten: Bacterial exotoxins inhibit translation to activate NLRP1	33
Immunologic signatures of response and resistance to nivolumab with ipilimumab in advanced metastatic cancer	33
Charting the meningeal lymphatic network	32
Iron TAMs: The fallen protectors	32
Urine scRNAseq reveals new insights into the bladder tumor immune microenvironment	32
Megakaryopoiesis impairment through acute innate immune signaling activation by azacitidine	32
Gut dysbiosis from high-salt diet promotes glioma via propionate-mediated TGF-β activation	31
Individuals with JAK1 variants are affected by syndromic features encompassing autoimmunity, atopy, colitis, and dermatitis	31
Rare SH2B3 coding variants in lupus patients impair B cell tolerance and predispose to autoimmunity	31
Lysophosphatidylserines derived from microbiota in Crohn’s disease elicit pathological Th1 response	31
Tumor-instructed glutamine synthesis in cancer-associated fibroblasts promotes pro-tumor macrophages	31
Th17-to-Tfh plasticity during periodontitis limits disease pathology	31
VEGF-C prophylaxis favors lymphatic drainage and modulates neuroinflammation in a stroke model	31
Recessive inborn errors of type I IFN immunity in children with COVID-19 pneumonia	31
Macro-clusters: CD301b+ DCs prime Th2 responses	30
Role of PRC2 in the stochastic expression of Aire target genes and development of mimetic cells in the thymus	30

Fueling the fire in the gut	30
Correction: TRAF3–EWSR1 signaling axis acts as a checkpoint on germinal center responses	30
Distinct molecular profiles drive multifaceted characteristics of colorectal cancer metastatic seeds	30
No added sugar: CCDC134 stabilizes ER chaperone Gp96 for TLR biogenesis	30
Clonal lineage tracing reveals mechanisms skewing CD8+ T cell fate decisions in chronic infection	29
Glucosamine amends CNS pathology in mucopolysaccharidosis IIIC mouse expressing misfolded HGSNAT	29
Human CARMIL2 deficiency underlies a broader immunological and clinical phenotype than CD28 deficiency	29
Pathogenic autoantibodies to IFN-γ act through the impedance of receptor assembly and Fc-mediated response	29
The PML hub: An emerging actor of leukemia therapies	29
Microbiota and adipocyte mitochondrial damage in type 2 diabetes are linked by Mmp12+ macrophages	29
Use of 3M-052-AF with Alum adjuvant in HIV trimer vaccine induces human autologous neutralizing antibodies	29
Tumor-associated neutrophils attenuate the immunosensitivity of hepatocellular carcinoma	28
KLF2 expression in IgG plasma cells at their induction site regulates the migration program	28
IL-17A–producing γδT cells promote muscle regeneration in a microbiota-dependent manner	28
Lymph node fibroblastic reticular cells regulate differentiation and function of CD4 T cells via CD25	28
Eating away T cell responses in lung cancer	28
Identifying genetic errors of immunity due to mosaicism	28
Inborn errors of TLR3- or MDA5-dependent type I IFN immunity in children with enterovirus rhombencephalitis	28
Heterologous mucosal vaccine boosting enhances mucosal and systemic immunity by distinct mechanisms	28
Act1 drives chemoresistance via regulation of antioxidant RNA metabolism and redox homeostasis	28
STAT3 gain of function: Too much of a good thing in the skin!	27
Recurrent infection transiently expands human tissue T cells while maintaining long-term homeostasis	27
Landscape of mast cell populations across organs in mice and humans	27
Linda-Gail Bekker: Mentorship is critical for anyone in STEM	27
Expression of Concern: ΔNp73, A Dominant-Negative Inhibitor of Wild-type p53 and TAp73, Is Up-regulated in Human Tumors	27
S1PR1 regulates lymphatic valve development and tertiary lymphoid organ formation in the ileum	27
Emerging in vivo tools for ILC2 research	27
Lymph node metastasis: An immunological burden	26
Baseline colitogenicity and acute perturbations of gut microbiota in immunotherapy-related colitis	26
PARP7 inhibits type I interferon signaling to prevent autoimmunity and lung disease	26
Mechanosensing regulates pDC activation in the skin through NRF2 activation	26
Stopping the fat: Repurposing an antidepressant for cancer treatment	26
The stunning clodronate	26
Modeling memory B cell responses in a lymphoid organ-chip to evaluate mRNA vaccine boosting	25
Perturbation of calreticulin potentiates CD8+ T cell–mediated antitumor immunity	25
OX40L-expressing recombinant modified vaccinia virus Ankara induces potent antitumor immunity via reprogramming Tregs	25
Single-cell transcriptomic analysis of human colonic macrophages reveals niche-specific subsets	25
Delineating a serotonin 1B receptor circuit for appetite suppression in mice	25
NADPH oxidase exerts a B cell–intrinsic contribution to lupus risk by modulating endosomal TLR signals	25
Five decades of natural killer cell discovery	25
Mitochondrial pyruvate metabolism and glutaminolysis toggle steady-state and emergency myelopoiesis	25
Intravenous administration of BCG protects mice against lethal SARS-CoV-2 challenge	25
Correction: Single-cell analysis of the cellular heterogeneity and interactions in the injured mouse spinal cord	25
The X factor in neurodegeneration	25
PD-1 and TIM-3 differentially regulate subsets of mouse IL-17A–producing γδ T cells	25
An engineered concealed IL-15-R elicits tumor-specific CD8+T cell responses through PD-1-cis delivery	25
Guardians of the oral barriers	24
Trained immunity of alveolar macrophages enhances injury resolution via KLF4-MERTK-mediated efferocytosis	24
Mutations disrupting the kinase domain of IKKα lead to immunodeficiency and immune dysregulation in humans	24
Periductal fibroblasts participate in liver homeostasis, fibrosis, and tumorigenesis	24
GIMAP6 regulates autophagy, immune competence, and inflammation in mice and humans	24
OTULIN and Muller’s morphs	24
BATF represses BIM to sustain tolerant T cells in the periphery	24
In vivo antibody diversification targeting a conserved coronavirus epitope	24
Lymphatic transport in anti-tumor immunity and metastasis	23
A TNF-IL-1 circuit controls Yersinia within intestinal pyogranulomas	23
Repertoire, function, and structure of serological antibodies induced by the R21/Matrix-M malaria vaccine	23
A half-century of research on tuberculosis: Successes and challenges	23
Filamin A editing in myeloid cells reduces intestinal inflammation and protects from colitis	23
Stability and heterogeneity in the antimicrobiota reactivity of human milk-derived immunoglobulin A	23
Tumor cell–intrinsic Piezo2 drives radioresistance by impairing CD8+ T cell stemness maintenance	23
Modulation of tissue resident memory T cells by glucocorticoids after acute cellular rejection in lung transplantation	23
Immunopathological and microbial signatures of inflammatory bowel disease in partial RAG deficiency	23
A viral E3 ubiquitin ligase produced by herpes simplex virus 1 inhibits the NLRP1 inflammasome	23
A “multi-omics” analysis of blood–brain barrier and synaptic dysfunction in APOE4 mice	23
NLRP1 activation by UVB: Shedding light on an enigmatic inflammasome	22
MCRS1 sensitizes T cell–dependent immunotherapy by augmenting MHC-I expression in solid tumors	22
Trophoblast antigens, fetal blood cell antigens, and the paradox of fetomaternal tolerance	22
Fetal MAVS and type I IFN signaling pathways control ZIKV infection in the placenta and maternal decidua	22
Inflammatory and tolerogenic myeloid cells determine outcome following human allergen challenge	22
EML4-ALK fusions drive lung adeno-to-squamous transition through JAK-STAT activation	22
Correction: Mitophagy-mediated adipose inflammation contributes to type 2 diabetes with hepatic insulin resistance	22
Correction: Respiratory viral infections in otherwise healthy humans with inherited IRF7 deficiency	22
Inositol phosphatase INPP4B sustains ILC1s and intratumoral NK cells through an AKT-driven pathway	22
Kids’ noses resist COVID-19	22
Transfer of nuclear and ribosomal material from Sox10-lineage cells to neurons in the mouse brain	21
Microglia modulate blood flow, neurovascular coupling, and hypoperfusion via purinergic actions	21
Design and characterization of HIV-1 vaccine candidates to elicit antibodies targeting multiple epitopes	21
Glymphatic system clears extracellular tau and protects from tau aggregation and neurodegeneration	21
Incontinentia pigmenti underlies thymic dysplasia, autoantibodies to type I IFNs, and viral diseases	21
Toward an understanding of allogeneic conflict in pregnancy and transplantation	21
Angiotensin II enhances group 2 innate lymphoid cell responses via AT1a during airway inflammation	21
Developing high-affinity decoy receptors to treat multiple myeloma and diffuse large B cell lymphoma	21
Loss of tolerance precedes triggering and lifelong persistence of pathogenic type I interferon autoantibodies	21
ICOS costimulation in combination with CTLA-4 blockade remodels tumor-associated macrophages toward an antitumor phenotype	21
Dynamic alterations of dural and bone marrow B cells in an animal model of progressive multiple sclerosis	21
The X in seX-biased immunity and autoimmune rheumatic disease	21
Transient inhibition of type I interferon enhances CD8+ T cell stemness and vaccine protection	21
Slow cycling and durable Flt3+ progenitors contribute to hematopoiesis under native conditions	21
Women in STEM becoming independent: Put science and discovery ahead of your ego	21
Helminths revive to survive	20
Tissue-resident NK cells do their own glandscaping	20
Breast cancer gene-1 (BRCA1) potentiates maladaptive repair after kidney injury	20
Natural rodent model of viral transmission reveals biological features of virus population dynamics	20
Inhibition of GABAA receptors in intestinal stem cells prevents chemoradiotherapy-induced intestinal toxicity	20