Journal of Experimental Medicine

Article	Citations
Primary tumor–derived systemic nANGPTL4 inhibits metastasis	265
SARS-CoV-2 Spike protein suppresses CTL-mediated killing by inhibiting immune synapse assembly	159
The pathogenic role of retinoid nuclear receptor signaling in cancer and metabolic syndromes	140
Intestinal epithelial c-Maf expression determines enterocyte differentiation and nutrient uptake in mice	140
IL-21 shapes germinal center polarization via light zone B cell selection and cyclin D3 upregulation	127
Antibody feedback contributes to facilitating the development of Omicron-reactive memory B cells in SARS-CoV-2 mRNA vaccinees	121
B cell receptor ligation induces IgE plasma cell elimination	121
An iron-rich subset of macrophages promotes tumor growth through a Bach1-Ednrb axis	120
Familial pulmonary alveolar proteinosis and type I interferonopathy by mutation of STAT2 (TIMS2)	117
RORγt eTACs mediate oral tolerance and Treg induction	116
Leveraging cDC1 biology and function for enhanced immunotherapy	113
Epitope and HLA specificity of human TCRs against Plasmodium falciparum circumsporozoite protein	108
ALK2/3 recruitment to the immunological synapse is required for T cell activation and death	103
Local gene editing of fibroblasts in tumors reveals a new cancer-associated fibroblast state	103
Host factor TIMP1 sustains long-lasting myeloid-biased hematopoiesis after severe infection	102
Early innate role for CD8αα+ cells in tuberculosis	101
Common cold embecovirus imprinting primes broadly neutralizing antibody responses to SARS-CoV-2 S2	98
S1PR1, an endothelial-immune influencer	98
Prenatally derived macrophages support choroidal health and decline in age-related macular degeneration	92
Antigen-independent, autonomous B cell receptor signaling drives activated B cell DLBCL	91
High burden of viruses and bacterial pathobionts drives heightened nasal innate immunity in children	91
Correction: Segmented filamentous bacteria–induced epithelial MHCII regulates cognate CD4+ IELs and epithelial turnover	90
Correction: ICAM-1 controls development and function of ILC2	90
Transit-amplifying cells control R-spondins in the mouse crypt to modulate intestinal stem cell proliferation	90
Lymphatic chain gradients regulate the magnitude and heterogeneity of T cell responses to vaccination	88

Challenges in TB research	88
NFAT5 governs cellular plasticity-driven resistance to KRAS-targeted therapy in pancreatic cancer	86
T cell engagers emerge as a compelling therapeutic modality	86
TIGIT mediates activation-induced cell death of ILC2s during chronic airway allergy	86
CXCL12+ dermal fibroblasts promote neutrophil recruitment and host defense by recognition of IL-17	82
IFNγ score–based neoadjuvant immunotherapy for stage III melanoma	81
Heterozygous human JAK2V617F activates AhR to drive essential thrombocythemia and promote thrombosis	79
Obesity alters monocyte developmental trajectories to enhance metastasis	79
Non-professional efferocytosis of Salmonella -infected intestinal epithelial cells in the neonatal host	78
Correction: CD55 regulates self-renewal and cisplatin resistance in endometrioid tumors	77
The genetic background shapes the susceptibility to mitochondrial dysfunction and NASH progression	75
CD8+ T cell depletion prevents neuropathology in a mouse model of globoid cell leukodystrophy	72
Interferon-λ drives renal fibrosis by coordinating epithelial–fibroblast crosstalk	72
A human STAT3 gain-of-function variant drives local Th17 dysregulation and skin inflammation in mice	72
Loss of ATG7 in microglia impairs UPR, triggers ferroptosis, and weakens amyloid pathology control	69
pDCs, type 1 IFN, and the female predileXion of SSc	69
Dual role of vascular endothelial growth factor-C in post-stroke recovery	68
Michelle Linterman: We are always learning	67
How decreasing T cell signaling unexpectedly results in autoimmunity	67
Nina Cabezas Wallscheid: Enjoying the freedom to decide my research path	66
Memory B cell responses to Omicron subvariants after SARS-CoV-2 mRNA breakthrough infection in humans	62
Deficiency for SAMHD1 activates MDA5 in a cGAS/STING-dependent manner	61
Addendum: RAF/MEK/extracellular signal–related kinase pathway suppresses dendritic cell migration and traps dendritic cells in Langerhans cell histiocytosis lesions	60
Augmenting neurogenesis rescues memory impairments in Alzheimer’s disease by restoring the memory-storing neurons	60
eIF3e-mediated translational checkpoint maintains immune tolerance and prevents lymphoid malignancy	59
Rethinking disomy: Autosomal expression bias	58
Promiscuous recognition of MR1 drives self-reactive mucosal-associated invariant T cell responses	58
IEC-intrinsic IL-1R signaling holds dual roles in regulating intestinal homeostasis and inflammation	58
Immunomolecular and reactivity landscapes of gut IgA subclasses in homeostasis and inflammatory bowel disease	57
PRECISE-seq reveals disease-relevant TCR repertoires with phenotypic plasticity	57
Functional specialization of short-lived and long-lived macrophage subsets in human tonsils	57
Spatiotemporal dynamics of fetal liver hematopoietic niches	56
MYO1F in neutrophils is required for the response to immune checkpoint blockade therapy	56
MYC is a clinically significant driver of mTOR inhibitor resistance in breast cancer	56
Protective fibroblastic niches in secondary lymphoid organs	55
A twist in the tail: Of T cell subsets and disease	54
Pleiotrophin drives a prometastatic immune niche in breast cancer	54
Oral antigen exposure under costimulation blockade induces Treg cells to establish immune tolerance	54
Somatic gain-of-function mutations in BUD13 promote oncogenesis by disrupting Fbw7 function	53
Tingible body macrophages: Gargantuan chameleons of the germinal center	53
Inherited human ITK deficiency impairs IFN-γ immunity and underlies tuberculosis	53
CD150-dependent hematopoietic stem cell sensing of Brucella instructs myeloid commitment	52
Protein arginine methyltransferase 1 regulates B cell fate after positive selection in the germinal center in mice	51
Targeting infection-specific peptides in immunopeptidomics studies for vaccine target discovery	50
Amino acid availability acts as a metabolic rheostat to determine the magnitude of ILC2 responses	49
Sara Suliman: Science is better when it’s shared	48
Correction: Chromatin landscapes reveal developmentally encoded transcriptional states that define human glioblastoma	48
Correction: SCFβ-TRCP suppresses angiogenesis and thyroid cancer cell migration by promoting ubiquitination and destruction of VEGF receptor 2	48
Correction: REV-ERB regulates RORγt+ regulatory T cell specification and function through the Bhlhe40-c-Maf axis	48
Correction: Role of affinity in plasma cell development in the germinal center light zone	47

Correction: Mouse model of SARS-CoV-2 reveals inflammatory role of type I interferon signaling	47
Tumor-derived OBP2A promotes prostate cancer castration resistance	47
Correction: B cell tolerance and antibody production to the celiac disease autoantigen transglutaminase 2	47
Targeting neuroinflammation in neuropathic pain and opioid use	46
The common HAQ STING allele prevents clinical penetrance of COPA syndrome	45
Macrophages in the synovial lining niche initiate neutrophil recruitment and articular inflammation	45
Gain-of-function human UNC93B1 variants cause systemic lupus erythematosus and chilblain lupus	45
IgD from atypical-like memory B cells and plasma cells targets commensal and environmental antigens	45
Activating NO–sGC crosstalk in the mouse vascular niche promotes vascular integrity and mitigates acute lung injury	45
Chimeric MHC class I– and II–restricted non-self epitopes broaden antitumor T cell reactions	44
Immature B cell homing shapes human lymphoid tissue structure and function	44
TCR signaling induces STAT3 phosphorylation to promote TH17 cell differentiation	44
Altered X-chromosome inactivation of the TLR7/8 locus and heterogeneity of pDCs in systemic sclerosis	44
Epigenetic and metabolic reprogramming support plasma cell differentiation in germinal centers	43
Hnf4 activates mimetic-cell enhancers to recapitulate gut and liver development within the thymus	42
Ki67 deficiency impedes chromatin accessibility and BCR gene rearrangement	42
NK cell expansion requires HuR and mediates control of solid tumors and long-term virus infection	42
Regulatory T cells converted from Th1 cells in tumors suppress cancer immunity via CD39	42
Changing behind the scenes	42
Differential impact of lymphatic outflow pathways on cerebrospinal fluid homeostasis	42
CTLA4 prohibits T cells from cross-dressing	42
TET2–STAT3–CXCL5 nexus promotes neutrophil lipid transfer to fuel lung adeno-to-squamous transition	41
CAR-T cell manufacturing: Major process parameters and next-generation strategies	40
Laura Mackay: Don't be afraid to engage	40
CD4+ T cell dysfunction in cancer	40
Perfecting antigen prediction	40
Correction: Profiling HPV-16–specific T cell responses reveals broad antigen reactivities in oropharyngeal cancer patients	39
Addendum: Resolvins suppress tumor growth and enhance cancer therapy	39
Correction: Antigen-presenting autoreactive B cells activate regulatory T cells and suppress autoimmune arthritis in mice	39
Chronic activation of pDCs in autoimmunity is linked to dysregulated ER stress and metabolic responses	39
Women in STEM becoming independent: The journey to independence is an immensely gratifying odyssey	39
Correction: Precursor central memory versus effector cell fate and naïve CD4+ T cell heterogeneity	39
A cell-free antigen processing system informs HIV-1 epitope selection and vaccine design	38
Dominant negative OTULIN-related autoinflammatory syndrome	38
Age- and diet-instructed metabolic rewiring of the tumor–immune microenvironment	37
A path forward for Staphylococcus aureus vaccine development	37
Neonatal microbiota colonization primes maturation of goblet cell–mediated protection in the pre-weaning colon	37
Succinate-producing microbiota drives tuft cell hyperplasia to protect against Clostridioides difficile	37
Coxsackievirus A10 impairs nail regeneration and induces onychomadesis by mimicking DKK1 to attenuate Wnt signaling	37
Distinct fibroblast progenitor subpopulation expedites regenerative mucosal healing by immunomodulation	37
Loss of ARID3A perturbs intestinal epithelial proliferation–differentiation ratio and regeneration	37
MHC one–two punch knocks out cancer	36
Vision rescue via unconstrained in vivo prime editing in degenerating neural retinas	36
IFNγ-induced memory in human macrophages is sustained by the durability of cytokine signaling itself	36
Liver-X-receptor agonism enhances T cell priming and activation to promote anti-tumor immunity	36
CSF1R-dependent CD169-positive macrophages locally constrain melanoma growth in the skin	35
Hemifacial myohyperplasia is due to somatic muscular PIK3CA gain-of-function mutations and responds to pharmacological inhibition	35
Cigarette smoke components modulate the MR1–MAIT axis	35
Competitive fungal commensalism mitigates candidiasis pathology	35
Staying IgD positive in a challenging environment	35
Dynamic Foxp3–chromatin interaction controls tunable Treg cell function	34
CD163+ macrophages monitor enhanced permeability at the blood–dorsal root ganglion barrier	34
Megakaryopoiesis impairment through acute innate immune signaling activation by azacitidine	34
Intravital imaging of pulmonary lymphatics in inflammation and metastatic cancer	34
Repurposing a tricyclic antidepressant in tumor and metabolism disease treatment through fatty acid uptake inhibition	34
Membrane-IL12 adjuvant mRNA vaccine polarizes pre-effector T cells for optimized tumor control	33
RIPK1 S161 phosphorylation promotes further autophosphorylation and cecal necroptosis in TNF-treated mice	33
Individuals with JAK1 variants are affected by syndromic features encompassing autoimmunity, atopy, colitis, and dermatitis	33
Nucleotide modifications enable rational design of TLR7-selective ligands by blocking RNase cleavage	33
Stalled but not forgotten: Bacterial exotoxins inhibit translation to activate NLRP1	33
HMCN1 variants aggravate epidermolysis bullosa simplex phenotype	32
Urine scRNAseq reveals new insights into the bladder tumor immune microenvironment	32
Iron TAMs: The fallen protectors	32
Immunologic signatures of response and resistance to nivolumab with ipilimumab in advanced metastatic cancer	32
In vivo CRISPR/Cas9 screens identify new regulators of B cell activation and plasma cell differentiation	32
Targeting UBE2F induces a resilience program enhancing CD8 T cell immunity	31
Correction: TRAF3–EWSR1 signaling axis acts as a checkpoint on germinal center responses	31
Rare SH2B3 coding variants in lupus patients impair B cell tolerance and predispose to autoimmunity	31
Clonal lineage tracing reveals mechanisms skewing CD8+ T cell fate decisions in chronic infection	31
VEGF-C prophylaxis favors lymphatic drainage and modulates neuroinflammation in a stroke model	31
RAC2 gain-of-function variants causing inborn error of immunity drive NLRP3 inflammasome activation	31
Role of PRC2 in the stochastic expression of Aire target genes and development of mimetic cells in the thymus	31
Eating away T cell responses in lung cancer	31
Tumor-instructed glutamine synthesis in cancer-associated fibroblasts promotes pro-tumor macrophages	31
Tumor-associated neutrophils attenuate the immunosensitivity of hepatocellular carcinoma	30
Use of 3M-052-AF with Alum adjuvant in HIV trimer vaccine induces human autologous neutralizing antibodies	30
B7 costimulation antagonizes RORγt+ regulatory T cells and immune tolerance in the intestine	30
Does fever drive the evolution of antiviral genes?	30
Splenic cDC1 efferocytosis and cross-presentation to CD8 T cells are promoted by GPR34 and lysophosphatidylserine	30
Gut dysbiosis from high-salt diet promotes glioma via propionate-mediated TGF-β activation	30

Human CARMIL2 deficiency underlies a broader immunological and clinical phenotype than CD28 deficiency	30
Bidirectional regulation by BACH2 coordinates systemic CXCR5− vs. CXCR5+ CD4+ T cell differentiation	30
Th17-to-Tfh plasticity during periodontitis limits disease pathology	30
Distinct molecular profiles drive multifaceted characteristics of colorectal cancer metastatic seeds	29
Macro-clusters: CD301b+ DCs prime Th2 responses	29
Expression of Concern: ΔNp73, A Dominant-Negative Inhibitor of Wild-type p53 and TAp73, Is Up-regulated in Human Tumors	29
No added sugar: CCDC134 stabilizes ER chaperone Gp96 for TLR biogenesis	29
The PML hub: An emerging actor of leukemia therapies	29
Emerging in vivo tools for ILC2 research	28
Lymph node metastasis: An immunological burden	28
The stunning clodronate	28
The X factor in neurodegeneration	28
Mechanosensing regulates pDC activation in the skin through NRF2 activation	27
Heterologous mucosal vaccine boosting enhances mucosal and systemic immunity by distinct mechanisms	27
STAT3 gain of function: Too much of a good thing in the skin!	27
Recurrent infection transiently expands human tissue T cells while maintaining long-term homeostasis	27
Linda-Gail Bekker: Mentorship is critical for anyone in STEM	27
A PI3Kδ-Foxo1-FasL signaling amplification loop rewires CD4+ T cell signaling and differentiation	27
Stopping the fat: Repurposing an antidepressant for cancer treatment	27
Baseline colitogenicity and acute perturbations of gut microbiota in immunotherapy-related colitis	26
PARP7 inhibits type I interferon signaling to prevent autoimmunity and lung disease	26
Modeling memory B cell responses in a lymphoid organ-chip to evaluate mRNA vaccine boosting	26
XPR1 regulates fetal liver macrophage development, identity, and pyrenocyte clearance	26
S1PR1 regulates lymphatic valve development and tertiary lymphoid organ formation in the ileum	26
Identifying genetic errors of immunity due to mosaicism	26
KLF2 expression in IgG plasma cells at their induction site regulates the migration program	26
Act1 drives chemoresistance via regulation of antioxidant RNA metabolism and redox homeostasis	26
Myeloid diversity in tumors: Shaped by genes, location, and time	26
An engineered concealed IL-15-R elicits tumor-specific CD8+T cell responses through PD-1-cis delivery	25
Landscape of mast cell populations across organs in mice and humans	25
Lymphatic transport in anti-tumor immunity and metastasis	25
Retraction: Tumors with TSC mutations are sensitive to CDK7 inhibition through NRF2 and glutathione depletion	25
Periductal fibroblasts participate in liver homeostasis, fibrosis, and tumorigenesis	25
PD-1 and TIM-3 differentially regulate subsets of mouse IL-17A–producing γδ T cells	25
Tissue-type plasminogen activator protects against kidney damage in invasive fungal infection	25
Correction: Single-cell analysis of the cellular heterogeneity and interactions in the injured mouse spinal cord	25
Correction: Hepatic IRE1α-XBP1 signaling promotes GDF15-mediated anorexia and body weight loss in chemotherapy	25
BATF represses BIM to sustain tolerant T cells in the periphery	25
Tumor cell–intrinsic Piezo2 drives radioresistance by impairing CD8+ T cell stemness maintenance	25
Trained immunity of alveolar macrophages enhances injury resolution via KLF4-MERTK-mediated efferocytosis	24
Mitochondrial pyruvate metabolism and glutaminolysis toggle steady-state and emergency myelopoiesis	24
Filamin A editing in myeloid cells reduces intestinal inflammation and protects from colitis	24
NADPH oxidase exerts a B cell–intrinsic contribution to lupus risk by modulating endosomal TLR signals	24
Five decades of natural killer cell discovery	24
Mutations disrupting the kinase domain of IKKα lead to immunodeficiency and immune dysregulation in humans	24
OX40L-expressing recombinant modified vaccinia virus Ankara induces potent antitumor immunity via reprogramming Tregs	24
A TNF-IL-1 circuit controls Yersinia within intestinal pyogranulomas	24
Stability and heterogeneity in the antimicrobiota reactivity of human milk-derived immunoglobulin A	24
A half-century of research on tuberculosis: Successes and challenges	24
In vivo antibody diversification targeting a conserved coronavirus epitope	23
Repertoire, function, and structure of serological antibodies induced by the R21/Matrix-M malaria vaccine	23
Correction: Respiratory viral infections in otherwise healthy humans with inherited IRF7 deficiency	23
NLRP1 activation by UVB: Shedding light on an enigmatic inflammasome	23
Guardians of the oral barriers	23
OTULIN and Muller’s morphs	23
A “multi-omics” analysis of blood–brain barrier and synaptic dysfunction in APOE4 mice	23
Next-generation CRISPR screens enable causal systems immunology	23
Immunopathological and microbial signatures of inflammatory bowel disease in partial RAG deficiency	23
Perturbation of calreticulin potentiates CD8+ T cell–mediated antitumor immunity	23
A viral E3 ubiquitin ligase produced by herpes simplex virus 1 inhibits the NLRP1 inflammasome	23
Inflammatory and tolerogenic myeloid cells determine outcome following human allergen challenge	23
Correction: Mitophagy-mediated adipose inflammation contributes to type 2 diabetes with hepatic insulin resistance	23
Women in STEM becoming independent: Put science and discovery ahead of your ego	22
Tet2 deficiency–induced expansion of monocyte-derived macrophages promotes liver fibrosis	22
Dynamics of natural and pharmacologic control of an SIV variant with an envelope trafficking defect	22
ICOS costimulation in combination with CTLA-4 blockade remodels tumor-associated macrophages toward an antitumor phenotype	22
Dynamic alterations of dural and bone marrow B cells in an animal model of progressive multiple sclerosis	22
The cribriform plate: A dynamic central nervous system–immune hub	22
Who gets the calories? An endothelial checkpoint for fat expansion	22
Design and characterization of HIV-1 vaccine candidates to elicit antibodies targeting multiple epitopes	22
Slow cycling and durable Flt3+ progenitors contribute to hematopoiesis under native conditions	21
Transfer of nuclear and ribosomal material from Sox10-lineage cells to neurons in the mouse brain	21
MCRS1 sensitizes T cell–dependent immunotherapy by augmenting MHC-I expression in solid tumors	21
A nerve and mast cell sentinel system releases extracellular condensates to induce macrophage repair	21
EML4-ALK fusions drive lung adeno-to-squamous transition through JAK-STAT activation	21
Single-cell and spatial profiling highlights TB-induced myofibroblasts as drivers of lung pathology	21
Kids’ noses resist COVID-19	21
Fetal MAVS and type I IFN signaling pathways control ZIKV infection in the placenta and maternal decidua	21
Transient inhibition of type I interferon enhances CD8+ T cell stemness and vaccine protection	21
Loss of tolerance precedes triggering and lifelong persistence of pathogenic type I interferon autoantibodies	20
Correction: Germinal center–dependent and –independent memory B cells produced throughout the immune response	20
Progressive differentiation toward the long-lived plasma cell compartment in the bone marrow	20
Inositol phosphatase INPP4B sustains ILC1s and intratumoral NK cells through an AKT-driven pathway	20
Helminths revive to survive	20
TGF-β promotes stem-like T cells via enforcing their lymphoid tissue retention	20
Inhibition of GABAA receptors in intestinal stem cells prevents chemoradiotherapy-induced intestinal toxicity	20
Incontinentia pigmenti underlies thymic dysplasia, autoantibodies to type I IFNs, and viral diseases	20
Addendum: Protein arginine methyltransferase 1 regulates B cell fate after positive selection in the germinal center in mice	20
cDC1-derived IL-27 regulates small intestinal CD4+ T cell homeostasis in mice	20
Identification of an anergic BND cell–derived activated B cell population (BND2) in young-onset type 1 diabetes patients	19
CNOT3 supports ILC2 differentiation and function by destabilizing Tbx21 and Rorc transcripts	19
T helper 2 cells in asthma	19
Brain-infiltrating ILC2s boost poststroke angiogenic initiation through α-CGRP production	19
Humans homozygous for rare or common hypomorphic IL23R variants are prone to tuberculosis	19
Tissue-resident NK cells do their own glandscaping	19