OOIR: Observatory of International Research

Papers

(The TQCC of Journal of Clinical Investigation is 57. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-02-01 to 2025-02-01.)

Article	Citations
Gastrointestinal motility disorders in neurologic disease	214
Age-specific effects of vaccine egg adaptation and immune priming on A(H3N2) antibody responses following influenza vaccination	188
Changes in the National Cancer Institute’s R01 workforce: growth, aging, retention, and policy implications	188
NOD2 drives early IL-33–dependent expansion of group 2 innate lymphoid cells during Crohn’s disease–like ileitis	168
An abundant biliary metabolite derived from dietary omega-3 polyunsaturated fatty acids regulates triglycerides	166
Propranolol inhibits cavernous vascular malformations by β1 adrenergic receptor antagonism in animal models	140
Paracardial fat and vitamin A: a mechanism for regulating exercise performance	128
Identification of SARS-CoV-2–specific immune alterations in acutely ill patients	125
Research gaps in medical treatment of transgender/nonbinary people	121
VCAM-1: closing the gap between lipotoxicity and endothelial dysfunction in nonalcoholic steatohepatitis	113
Plasma cells promote osteoclastogenesis and periarticular bone loss in autoimmune arthritis	111
Selective glutamine metabolism inhibition in tumor cells improves antitumor T lymphocyte activity in triple-negative breast cancer	108
Testosterone replacement in aging men: an evidence-based patient-centric perspective	107
A sobering addition to the literature on COVID-19 and the brain	101
Residual β cell function in long-term type 1 diabetes associates with reduced incidence of hypoglycemia	101
Remodeling glycerophospholipids affects obesity-related insulin signaling in skeletal muscle	96
CC17 group B Streptococcus exploits integrins for neonatal meningitis development	95
Lysophospholipid acylation modulates plasma membrane lipid organization and insulin sensitivity in skeletal muscle	89
Combined immunodeficiency due to a mutation in the γ1 subunit of the coat protein I complex	89
Targeting a Braf/Mapk pathway rescues podocyte lipid peroxidation in CoQ-deficiency kidney disease	85
Endoplasmic reticulum stress sensor IRE1α propels neutrophil hyperactivity in lupus	83
Inhibiting the MNK1/2-eIF4E axis impairs melanoma phenotype switching and potentiates antitumor immune responses	83
IRF3 reduces adipose thermogenesis via ISG15-mediated reprogramming of glycolysis	80
A replication-competent adenovirus-vectored influenza vaccine induces durable systemic and mucosal immunity	76
TREM2 sustains macrophage-hepatocyte metabolic coordination in nonalcoholic fatty liver disease and sepsis	74

SUMOylation promotes extracellular vesicle–mediated transmission of lncRNA ELNAT1 and lymph node metastasis in bladder cancer	73
Renal tubule Cpt1a overexpression protects from kidney fibrosis by restoring mitochondrial homeostasis	71
Neutrophil-to-hepatocyte communication via LDLR-dependent miR-223–enriched extracellular vesicle transfer ameliorates nonalcoholic steatohepatitis	70
Aberrant AZIN2 and polyamine metabolism precipitates tau neuropathology	68
Integrating imaging and RNA-seq improves outcome prediction in cervical cancer	67
Cyclin A2 maintains colon homeostasis and is a prognostic factor in colorectal cancer	66
Bone marrow niche ATP levels determine leukemia-initiating cell activity via P2X7 in leukemic models	65
Paracardial fat remodeling affects systemic metabolism through alcohol dehydrogenase 1	64
UDP-glucose and P2Y14 receptor amplify allergen-induced airway eosinophilia	63
ATM inhibition enhances cancer immunotherapy by promoting mtDNA leakage and cGAS/STING activation	62
Muscle Krüppel-like factor 15 regulates lipid flux and systemic metabolic homeostasis	62
YAP/TFEB pathway promotes autophagic cell death and hypertrophic cardiomyopathy in lysosomal storage diseases	60
RUNX2 regulates leukemic cell metabolism and chemotaxis in high-risk T cell acute lymphoblastic leukemia	58
Endoplasmic reticulum–associated degradation is required for nephrin maturation and kidney glomerular filtration function	57
A conversation with Robert Lefkowitz	57