Journal of Clinical Investigation

(The TQCC of Journal of Clinical Investigation is 59. The table below lists those papers that are above that threshold based on CrossRef citation counts. The publications cover those that have been published in the past four years, i.e., from 2019-03-01 to 2023-03-01.)
Clinical and immunological features of severe and moderate coronavirus disease 20193087
B cell maturation antigen–specific CAR T cells are clinically active in multiple myeloma389
IFN-I response timing relative to virus replication determines MERS coronavirus infection outcomes373
The new collagenase, collagenase-3, is expressed and synthesized by human chondrocytes but not by synoviocytes. A role in osteoarthritis.326
The role of macrophages in the resolution of inflammation301
Sex, age, and hospitalization drive antibody responses in a COVID-19 convalescent plasma donor population290
The gut microbiome and metabolic syndrome277
Altered adipose tissue and adipocyte function in the pathogenesis of metabolic syndrome271
Autonomic blockade by propranolol and atropine to study intrinsic myocardial function in man254
Metabolically healthy obesity: facts and fantasies235
Mildly oxidized LDL induces an increased apolipoprotein J/paraoxonase ratio.235
Contribution of adipogenesis to healthy adipose tissue expansion in obesity223
Electronic cigarettes disrupt lung lipid homeostasis and innate immunity independent of nicotine215
Ferroptotic cell death and TLR4/Trif signaling initiate neutrophil recruitment after heart transplantation199
Epithelial cell–derived cytokines: more than just signaling the alarm198
Lymphocytes, neuropeptides, and genes involved in alopecia areata196
Adipocyte-secreted exosomal microRNA-34a inhibits M2 macrophage polarization to promote obesity-induced adipose inflammation191
CD19 CAR T cell product and disease attributes predict leukemia remission durability182
Spatially distinct tumor immune microenvironments stratify triple-negative breast cancers182
PARP inhibition enhances tumor cell–intrinsic immunity in ERCC1-deficient non–small cell lung cancer168
Exosomal long noncoding RNA LNMAT2 promotes lymphatic metastasis in bladder cancer167
Endogenous retroviral signatures predict immunotherapy response in clear cell renal cell carcinoma164
Subchondral bone osteoclasts induce sensory innervation and osteoarthritis pain163
Self-associated molecular patterns mediate cancer immune evasion by engaging Siglecs on T cells160
Intact HIV-1 proviruses accumulate at distinct chromosomal positions during prolonged antiretroviral therapy158
Molecular profiling stratifies diverse phenotypes of treatment-refractory metastatic castration-resistant prostate cancer156
Functional significance of the platelet immune receptors GPVI and CLEC-2155
Blocking expression of inhibitory receptor NKG2A overcomes tumor resistance to NK cells153
Neoantigen screening identifies broad TP53 mutant immunogenicity in patients with epithelial cancers153
microRNA-21-5p dysregulation in exosomes derived from heart failure patients impairs regenerative potential147
Adipocyte and lipid metabolism in cancer drug resistance146
Convalescent plasma anti–SARS-CoV-2 spike protein ectodomain and receptor-binding domain IgG correlate with virus neutralization146
SARS-CoV-2–specific CD8+ T cell responses in convalescent COVID-19 individuals145
Endothelium-derived relaxing factor/nitric oxide modulates angiotensin II action in the isolated microperfused rabbit afferent but not efferent arteriole.144
IL-6/JAK1 pathway drives PD-L1 Y112 phosphorylation to promote cancer immune evasion144
Precision medicine and phenotypes, endotypes, genotypes, regiotypes, and theratypes of allergic diseases142
An alternative mitophagy pathway mediated by Rab9 protects the heart against ischemia141
JAK2-binding long noncoding RNA promotes breast cancer brain metastasis136
More friend than foe: the emerging role of neutrophils in tissue repair135
Monoclonal antibody targeting BDCA2 ameliorates skin lesions in systemic lupus erythematosus135
β Cell dysfunction during progression of metabolic syndrome to type 2 diabetes133
Environmental exposures and mechanisms in allergy and asthma development133
Association of class II human histocompatibility leukocyte antigens with rheumatic fever.131
RANKL inhibition improves muscle strength and insulin sensitivity and restores bone mass129
Human transforming growth factor-alpha stimulates bone resorption in vitro.125
Chronic phospholamban inhibition prevents progressive cardiac dysfunction and pathological remodeling after infarction in rats123
Maresin 1 activates LGR6 receptor promoting phagocyte immunoresolvent functions123
Yap/Taz regulate alveolar regeneration and resolution of lung inflammation123
Suppression of the SLC7A11/glutathione axis causes synthetic lethality in KRAS-mutant lung adenocarcinoma123
Pharmacological targeting of MYC-regulated IRE1/XBP1 pathway suppresses MYC-driven breast cancer121
The gut-bone axis: how bacterial metabolites bridge the distance120
Killers 2.0: NK cell therapies at the forefront of cancer control120
Posttransplantation cyclophosphamide prevents graft-versus-host disease by inducing alloreactive T cell dysfunction and suppression118
STING activation reprograms tumor vasculatures and synergizes with VEGFR2 blockade115
Interorgan communication by exosomes, adipose tissue, and adiponectin in metabolic syndrome114
Deciphering the cellular interplays underlying obesity-induced adipose tissue fibrosis113
Human colon mucosal biofilms from healthy or colon cancer hosts are carcinogenic112
Gut microbiota modulate dendritic cell antigen presentation and radiotherapy-induced antitumor immune response110
Autoimmune seizures and epilepsy109
Hedgehog signaling promotes tumor-associated macrophage polarization to suppress intratumoral CD8+ T cell recruitment107
Angiotensin II upregulates type-1 angiotensin II receptors in renal proximal tubule.106
Mutated nucleophosmin 1 as immunotherapy target in acute myeloid leukemia104
PTEN-opathies: from biological insights to evidence-based precision medicine103
Integrated RNA and DNA sequencing reveals early drivers of metastatic breast cancer103
Neoantigen identification strategies enable personalized immunotherapy in refractory solid tumors102
Innate immune cell–epithelial crosstalk during wound repair101
Neutrophils contribute to spontaneous resolution of liver inflammation and fibrosis via microRNA-223101
Enhancing glycolysis attenuates Parkinson’s disease progression in models and clinical databases101
Aspirin blocks formation of metastatic intravascular niches by inhibiting platelet-derived COX-1/thromboxane A2100
Recurrent YAP1-MAML2 and YAP1-NUTM1 fusions in poroma and porocarcinoma98
T follicular helper cells in human efferent lymph retain lymphoid characteristics98
Machine learning reveals serum sphingolipids as cholesterol-independent biomarkers of coronary artery disease97
β2 adrenergic receptor–mediated signaling regulates the immunosuppressive potential of myeloid-derived suppressor cells97
Shear stress–induced endothelial adrenomedullin signaling regulates vascular tone and blood pressure95
Identification of surface proteins mediating adherence of CD11/CD18-deficient lymphoblastoid cells to cultured human endothelium.95
Epithelial barrier repair and prevention of allergy94
Myo-inositol oxygenase expression profile modulates pathogenic ferroptosis in the renal proximal tubule94
HIV persists throughout deep tissues with repopulation from multiple anatomical sources94
Dominant-negative IKZF1 mutations cause a T, B, and myeloid cell combined immunodeficiency93
Tumor suppressor TET2 promotes cancer immunity and immunotherapy efficacy93
Neutrophil-induced genomic instability impedes resolution of inflammation and wound healing93
Tumor cell–intrinsic EPHA2 suppresses antitumor immunity by regulating PTGS2 (COX-2)92
Lactate inhibits ATP6V0d2 expression in tumor-associated macrophages to promote HIF-2α–mediated tumor progression91
Chronic stimulation drives human NK cell dysfunction and epigenetic reprograming91
Stress-induced epinephrine enhances lactate dehydrogenase A and promotes breast cancer stem-like cells90
cGAS/STING axis mediates a topoisomerase II inhibitor–induced tumor immunogenicity89
LEAP2 changes with body mass and food intake in humans and mice89
Oxidative stress in vagal neurons promotes parkinsonian pathology and intercellular α-synuclein transfer88
Targeting tumor-intrinsic hexosamine biosynthesis sensitizes pancreatic cancer to anti-PD1 therapy87
T cells genetically engineered to overcome death signaling enhance adoptive cancer immunotherapy87
Low- and high-thermogenic brown adipocyte subpopulations coexist in murine adipose tissue87
The natriuretic peptide/guanylyl cyclase–A system functions as a stress-responsive regulator of angiogenesis in mice87
Genetic hallmarks of recurrent/metastatic adenoid cystic carcinoma87
Tumor-secreted Pros1 inhibits macrophage M1 polarization to reduce antitumor immune response86
Single-cell RNA sequencing identifies inflammatory tissue T cells in eosinophilic esophagitis86
Dynamic ploidy changes drive fluconazole resistance in human cryptococcal meningitis86
Microbiota maintain colonic homeostasis by activating TLR2/MyD88/PI3K signaling in IL-10–producing regulatory B cells85
A maresin 1/RORα/12-lipoxygenase autoregulatory circuit prevents inflammation and progression of nonalcoholic steatohepatitis85
IFN-γ drives inflammatory bowel disease pathogenesis through VE-cadherin–directed vascular barrier disruption84
FOXM1 drives proximal tubule proliferation during repair from acute ischemic kidney injury83
APC-activated long noncoding RNA inhibits colorectal carcinoma pathogenesis through reduction of exosome production83
Dermal adipose tissue has high plasticity and undergoes reversible dedifferentiation in mice82
Fracture repair requires TrkA signaling by skeletal sensory nerves81
Effects of maternal iron status on placental and fetal iron homeostasis81
The X-linked histone demethylase Kdm6a in CD4+ T lymphocytes modulates autoimmunity79
Age-dependent SMN expression in disease-relevant tissue and implications for SMA treatment79
Long noncoding RNA NEXN-AS1 mitigates atherosclerosis by regulating the actin-binding protein NEXN79
Recognition of human gastrointestinal cancer neoantigens by circulating PD-1+ lymphocytes78
Functional diversification of IgGs through Fc glycosylation77
Macrophage-lineage TRAP+ cells recruit periosteum-derived cells for periosteal osteogenesis and regeneration77
Suppressing miR-21 activity in tumor-associated macrophages promotes an antitumor immune response77
Type I IFN protects cancer cells from CD8+ T cell–mediated cytotoxicity after radiation76
Inhibiting Wee1 and ATR kinases produces tumor-selective synthetic lethality and suppresses metastasis76
Heterotrimeric G proteins physically associated with the lipopolysaccharide receptor CD14 modulate both in vivo and in vitro responses to lipopolysaccharide.76
Epithelial-mesenchymal transition leads to NK cell–mediated metastasis-specific immunosurveillance in lung cancer75
Autoreactive CD8+ T cell exhaustion distinguishes subjects with slow type 1 diabetes progression75
Roles of HIFs and VEGF in angiogenesis in the retina and brain74
Antigen delivery targeted to tumor-associated macrophages overcomes tumor immune resistance74
Inherited p40phox deficiency differs from classic chronic granulomatous disease74
Splicing factor SRSF1 promotes gliomagenesis via oncogenic splice-switching of MYO1B74
Neuro-immune crosstalk and allergic inflammation73
Impact of estrogens in males and androgens in females73
Minimal PD-1 expression in mouse and human NK cells under diverse conditions73
ATP-binding cassette A1 deficiency causes cardiolipin-driven mitochondrial dysfunction in podocytes73
Autism-linked dopamine transporter mutation alters striatal dopamine neurotransmission and dopamine-dependent behaviors73
N-Myc–mediated epigenetic reprogramming drives lineage plasticity in advanced prostate cancer73
Peroxisome-derived lipids regulate adipose thermogenesis by mediating cold-induced mitochondrial fission71
IL-1β dominates the promucin secretory cytokine profile in cystic fibrosis71
Myocardial infarction triggers cardioprotective antigen-specific T helper cell responses70
c-Abl regulates YAPY357 phosphorylation to activate endothelial atherogenic responses to disturbed flow69
JAK2-V617F promotes venous thrombosis through β1/β2 integrin activation68
APOE4-mediated amyloid-β pathology depends on its neuronal receptor LRP168
Persistent HIV-infected cells in cerebrospinal fluid are associated with poorer neurocognitive performance68
Promises, promises, and precision medicine67
FoxO3 activation in hypoxic tubules prevents chronic kidney disease67
Inherited human IFN-γ deficiency underlies mycobacterial disease67
Stromal integrin α11 regulates PDGFRβ signaling and promotes breast cancer progression67
Circulating heparan sulfate fragments mediate septic cognitive dysfunction67
Lineage-specific events underlie aortic root aneurysm pathogenesis in Loeys-Dietz syndrome67
HIV-1 in lymph nodes is maintained by cellular proliferation during antiretroviral therapy67
Identifying and targeting pathogenic PI3K/AKT/mTOR signaling in IL-6 blockade–refractory idiopathic multicentric Castleman disease67
Mitochondria, OxPhos, and neurodegeneration: cells are not just running out of gas66
Preoperative stimulation of resolution and inflammation blockade eradicates micrometastases66
The alveolar immune cell landscape is dysregulated in checkpoint inhibitor pneumonitis66
Antibody Fc effector functions and IgG3 associate with decreased HIV-1 risk66
mTORC1-to-AMPK switching underlies β cell metabolic plasticity during maturation and diabetes65
Breast milk alkylglycerols sustain beige adipocytes through adipose tissue macrophages65
What lipodystrophies teach us about the metabolic syndrome64
Targeting innate immunity for tuberculosis vaccination64
AAV8-vectored suprachoroidal gene transfer produces widespread ocular transgene expression64
A Clostridia-rich microbiota enhances bile acid excretion in diarrhea-predominant irritable bowel syndrome64
Long telomeres and cancer risk: the price of cellular immortality63
Abolition of aberrant neurogenesis ameliorates cognitive impairment after stroke in mice63
Early adaptive immune activation detected in monozygotic twins with prodromal multiple sclerosis63
Chronic biliary obstruction induces pulmonary intravascular phagocytosis and endotoxin sensitivity in rats.63
Proximal tubule ATR regulates DNA repair to prevent maladaptive renal injury responses63
Galectin-1–driven T cell exclusion in the tumor endothelium promotes immunotherapy resistance62
CD33 recruitment inhibits IgE-mediated anaphylaxis and desensitizes mast cells to allergen61
A nonhuman primate model of inherited retinal disease61
Peptide-based PET quantifies target engagement of PD-L1 therapeutics61
Platelet-derived miR-223 promotes a phenotypic switch in arterial injury repair61
Molecular imaging of fibrosis: recent advances and future directions60
Membrane assembly of aquaporin-4 autoantibodies regulates classical complement activation in neuromyelitis optica60
Bacterial lipopolysaccharides induce in vitro degradation of cartilage matrix through chondrocyte activation.59
The local immune landscape determines tumor PD-L1 heterogeneity and sensitivity to therapy59
Metabolomic networks connect host-microbiome processes to human Clostridioides difficile infections59
ENTPD-1 disrupts inflammasome IL-1β–driven venous thrombosis59