Journal of Clinical Investigation

(The TQCC of Journal of Clinical Investigation is 50. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-02-01 to 2024-02-01.)
Clinical and immunological features of severe and moderate coronavirus disease 20193451
SARS-CoV-2: a storm is raging857
The convalescent sera option for containing COVID-19704
Deployment of convalescent plasma for the prevention and treatment of COVID-19579
Complement and tissue factor–enriched neutrophil extracellular traps are key drivers in COVID-19 immunothrombosis525
Kinetics of viral load and antibody response in relation to COVID-19 severity450
Impaired immune cell cytotoxicity in severe COVID-19 is IL-6 dependent392
SARS–CoV-2 infection of the placenta330
Sex, age, and hospitalization drive antibody responses in a COVID-19 convalescent plasma donor population329
Immune responses to stroke: mechanisms, modulation, and therapeutic potential328
Insulin resistance drives hepatic de novo lipogenesis in nonalcoholic fatty liver disease327
Early safety indicators of COVID-19 convalescent plasma in 5000 patients292
Multisystem inflammatory syndrome in children and COVID-19 are distinct presentations of SARS–CoV-2289
Distinct clinical and immunological features of SARS–CoV-2–induced multisystem inflammatory syndrome in children268
Recent endemic coronavirus infection is associated with less-severe COVID-19249
Type I interferon response drives neuroinflammation and synapse loss in Alzheimer disease246
Targeting glutamine metabolism enhances tumor-specific immunity by modulating suppressive myeloid cells210
mRNA vaccine–induced neoantigen-specific T cell immunity in patients with gastrointestinal cancer203
Chronic mirabegron treatment increases human brown fat, HDL cholesterol, and insulin sensitivity197
SARS-CoV-2–specific CD8+ T cell responses in convalescent COVID-19 individuals191
Baricitinib restrains the immune dysregulation in patients with severe COVID-19191
Suppression of the SLC7A11/glutathione axis causes synthetic lethality in KRAS-mutant lung adenocarcinoma180
SARS–CoV-2–specific T cell responses and correlations with COVID-19 patient predisposition170
Genomics of lethal prostate cancer at diagnosis and castration resistance166
Targeting tumor-associated macrophages and granulocytic myeloid-derived suppressor cells augments PD-1 blockade in cholangiocarcinoma165
Insulin signaling in health and disease163
Convalescent plasma anti–SARS-CoV-2 spike protein ectodomain and receptor-binding domain IgG correlate with virus neutralization161
HIFs, angiogenesis, and metabolism: elusive enemies in breast cancer158
COVID-19 severity associates with pulmonary redistribution of CD1c+ DCs and inflammatory transitional and nonclassical monocytes151
The β3-adrenergic receptor agonist mirabegron improves glucose homeostasis in obese humans148
Immune escape and immunotherapy of acute myeloid leukemia144
CD73 immune checkpoint defines regulatory NK cells within the tumor microenvironment136
Distinct interferon signatures and cytokine patterns define additional systemic autoinflammatory diseases135
Selective glutamine metabolism inhibition in tumor cells improves antitumor T lymphocyte activity in triple-negative breast cancer132
Impact of TREM2R47H variant on tau pathology–induced gliosis and neurodegeneration131
HIV persists throughout deep tissues with repopulation from multiple anatomical sources129
Renal tubule Cpt1a overexpression protects from kidney fibrosis by restoring mitochondrial homeostasis129
A tumor-intrinsic PD-L1/NLRP3 inflammasome signaling pathway drives resistance to anti–PD-1 immunotherapy128
Long-term microstructure and cerebral blood flow changes in patients recovered from COVID-19 without neurological manifestations128
Contributions of alveolar epithelial cell quality control to pulmonary fibrosis126
Peripheral CD4+ T cell subsets and antibody response in COVID-19 convalescent individuals120
Hypoxia-inducible factors and obstructive sleep apnea119
Herpesvirus latency114
TYRO3 induces anti–PD-1/PD-L1 therapy resistance by limiting innate immunity and tumoral ferroptosis114
TRPV4 channel opening mediates pressure-induced pancreatitis initiated by Piezo1 activation112
IL-17 and immunologically induced senescence regulate response to injury in osteoarthritis112
Truncated stathmin-2 is a marker of TDP-43 pathology in frontotemporal dementia111
The COVID-19 pandemic and research shutdown: staying safe and productive111
Circulating tumor DNA profile recognizes transformation to castration-resistant neuroendocrine prostate cancer110
Boosting NAD level suppresses inflammatory activation of PBMCs in heart failure108
IL-1β suppression of VE-cadherin transcription underlies sepsis-induced inflammatory lung injury107
Gut epithelial TSC1/mTOR controls RIPK3-dependent necroptosis in intestinal inflammation and cancer106
Single residue in CD28-costimulated CAR-T cells limits long-term persistence and antitumor durability106
Urine DNA methylation assay enables early detection and recurrence monitoring for bladder cancer106
Annexin A1 drives macrophage skewing to accelerate muscle regeneration through AMPK activation104
Radiotherapy-exposed CD8+ and CD4+ neoantigens enhance tumor control103
Bile acid metabolism is altered in multiple sclerosis and supplementation ameliorates neuroinflammation101
Circular RNA-ZNF532 regulates diabetes-induced retinal pericyte degeneration and vascular dysfunction100
Cytotoxic CD4+ T lymphocytes may induce endothelial cell apoptosis in systemic sclerosis100
Epigenetic driver mutations in ARID1A shape cancer immune phenotype and immunotherapy100
Immune dysregulation as a driver of idiopathic pulmonary fibrosis100
Endothelial C3a receptor mediates vascular inflammation and blood-brain barrier permeability during aging100
HPV16 drives cancer immune escape via NLRX1-mediated degradation of STING99
IRF4 instructs effector Treg differentiation and immune suppression in human cancer98
Transcription factor c-Maf is a checkpoint that programs macrophages in lung cancer98
p53/microRNA-214/ULK1 axis impairs renal tubular autophagy in diabetic kidney disease97
BCG vaccination history associates with decreased SARS-CoV-2 seroprevalence across a diverse cohort of health care workers97
Pharmacological treatment of hyperglycemia in type 2 diabetes97
ATM inhibition enhances cancer immunotherapy by promoting mtDNA leakage and cGAS/STING activation96
TREM2 sustains macrophage-hepatocyte metabolic coordination in nonalcoholic fatty liver disease and sepsis96
Hypoxia-inducible factor signaling in pulmonary hypertension96
Sleeping Beauty–engineered CAR T cells achieve antileukemic activity without severe toxicities95
Preventing cytokine storm syndrome in COVID-19 using α-1 adrenergic receptor antagonists94
Age-determined expression of priming protease TMPRSS2 and localization of SARS-CoV-2 in lung epithelium93
Microenvironmental Th9 and Th17 lymphocytes induce metastatic spreading in lung cancer93
Immunotherapy of multiple myeloma92
Bone marrow adipogenic lineage precursors promote osteoclastogenesis in bone remodeling and pathologic bone loss92
HDAC inhibitors elicit metabolic reprogramming by targeting super-enhancers in glioblastoma models91
Antigen-driven clonal selection shapes the persistence of HIV-1–infected CD4+ T cells in vivo91
Sustained cellular immune dysregulation in individuals recovering from SARS-CoV-2 infection91
Favorable outcomes of COVID-19 in recipients of hematopoietic cell transplantation91
Melatonin inhibits cytosolic mitochondrial DNA–induced neuroinflammatory signaling in accelerated aging and neurodegeneration91
Minimal PD-1 expression in mouse and human NK cells under diverse conditions88
Similarities and differences between the immunopathogenesis of COVID-19–related pediatric multisystem inflammatory syndrome and Kawasaki disease88
COVID-19 threatens health systems in sub-Saharan Africa: the eye of the crocodile88
Lung megakaryocytes are immune modulatory cells88
Parathyroid hormone–dependent bone formation requires butyrate production by intestinal microbiota87
Circulating markers of NADH-reductive stress correlate with mitochondrial disease severity87
Osteocyte necrosis triggers osteoclast-mediated bone loss through macrophage-inducible C-type lectin87
Altered glycosylation of IgG4 promotes lectin complement pathway activation in anti-PLA2R1–associated membranous nephropathy86
Biomarkers of inflammation and repair in kidney disease progression85
Functional monocytic myeloid-derived suppressor cells increase in blood but not airways and predict COVID-19 severity85
BCG vaccination in humans inhibits systemic inflammation in a sex-dependent manner84
COVID-19 survival associates with the immunoglobulin response to the SARS-CoV-2 spike receptor binding domain84
Corticosteroid treatment in severe COVID-19 patients with acute respiratory distress syndrome84
Circadian rhythm influences induction of trained immunity by BCG vaccination82
Opportunities and challenges in using real-world data for health care81
Transcriptome-directed analysis for Mendelian disease diagnosis overcomes limitations of conventional genomic testing81
Upregulation of Rubicon promotes autosis during myocardial ischemia/reperfusion injury81
Clinical trials for COVID-19 should include sex as a variable80
PD-1 blockade inhibits osteoclast formation and murine bone cancer pain80
Inherited human IFN-γ deficiency underlies mycobacterial disease80
Hypoxia-inducible factors and innate immunity in liver cancer80
Inhibition of mitophagy drives macrophage activation and antibacterial defense during sepsis79
S100A8/A9 regulates CD11b expression and neutrophil recruitment during chronic tuberculosis79
HIV-1 viremia not suppressible by antiretroviral therapy can originate from large T cell clones producing infectious virus79
Impaired complex I repair causes recessive Leber’s hereditary optic neuropathy79
Pancreatic ductal adenocarcinoma progression is restrained by stromal matrix76
Myalgic encephalomyelitis/chronic fatigue syndrome patients exhibit altered T cell metabolism and cytokine associations75
Pancreatic triglyceride lipase mediates lipotoxic systemic inflammation75
Immune checkpoint inhibitor–associated myocarditis: manifestations and mechanisms75
The lung microenvironment shapes a dysfunctional response of alveolar macrophages in aging74
Exebacase for patients with Staphylococcus aureus bloodstream infection and endocarditis74
Hypoxia-inducible factors and diabetes74
State of the art in CAR T cell therapy for CD19+ B cell malignancies73
Pembrolizumab plus allogeneic NK cells in advanced non–small cell lung cancer patients72
Dietary interventions for obesity: clinical and mechanistic findings72
Healthy donor T cell responses to common cold coronaviruses and SARS-CoV-271
Muscle-derived interleukin 6 increases exercise capacity by signaling in osteoblasts70
Monogenic diabetes: a gateway to precision medicine in diabetes70
Durable SARS-CoV-2 B cell immunity after mild or severe disease70
CD8+ T cells target cerebrovasculature in children with cerebral malaria70
Stiff stroma increases breast cancer risk by inducing the oncogene ZNF21769
Chemotherapy-induced S100A10 recruits KDM6A to facilitate OCT4-mediated breast cancer stemness69
BCL-2 antagonism sensitizes cytotoxic T cell–resistant HIV reservoirs to elimination ex vivo69
High residual C-peptide likely contributes to glycemic control in type 1 diabetes69
Neutrophil-to-hepatocyte communication via LDLR-dependent miR-223–enriched extracellular vesicle transfer ameliorates nonalcoholic steatohepatitis68
Glycerol-3-phosphate is an FGF23 regulator derived from the injured kidney68
Inhibition of the ATM/Chk2 axis promotes cGAS/STING signaling in ARID1A-deficient tumors67
TGF-β–induced epigenetic deregulation of SOCS3 facilitates STAT3 signaling to promote fibrosis67
An endocannabinoid-regulated basolateral amygdala–nucleus accumbens circuit modulates sociability67
Overcoming innate immune barriers that impede AAV gene therapy vectors67
Inflammatory syndromes associated with SARS-CoV-2 infection: dysregulation of the immune response across the age spectrum66
Inactivation of paracellular cation-selective claudin-2 channels attenuates immune-mediated experimental colitis in mice66
Longitudinal study reveals HIV-1–infected CD4+ T cell dynamics during long-term antiretroviral therapy66
Muscle-specific SMN reduction reveals motor neuron–independent disease in spinal muscular atrophy models65
Clinical, laboratory, and temporal predictors of neutralizing antibodies against SARS-CoV-2 among COVID-19 convalescent plasma donor candidates65
Mass cytometry detects H3.3K27M-specific vaccine responses in diffuse midline glioma65
Herpes simplex encephalitis in a patient with a distinctive form of inherited IFNAR1 deficiency64
Complementopathies and precision medicine64
New York City COVID-19 resident physician exposure during exponential phase of pandemic64
Gastrointestinal motility disorders in neurologic disease63
Kidney diseases in the time of COVID-19: major challenges to patient care63
Fecal microbiome and metabolome differ in healthy and food-allergic twins63
Exosomes mediate sensory hair cell protection in the inner ear62
Donor glucose-6-phosphate dehydrogenase deficiency decreases blood quality for transfusion62
Hypoxia-inducible factor activity promotes antitumor effector function and tissue residency by CD8+ T cells62
Inhibition of 2-hydroxyglutarate elicits metabolic reprogramming and mutant IDH1 glioma immunity in mice62
The knowns and unknowns of latent Mycobacterium tuberculosis infection62
A conserved intratumoral regulatory T cell signature identifies 4-1BB as a pan-cancer target61
Genome-wide plasma DNA methylation features of metastatic prostate cancer60
DCAF1 regulates Treg senescence via the ROS axis during immunological aging60
Sensory nerves regulate mesenchymal stromal cell lineage commitment by tuning sympathetic tones60
B cell–intrinsic TLR9 expression is protective in murine lupus59
dmPFC-vlPAG projection neurons contribute to pain threshold maintenance and antianxiety behaviors59
Antigen-specific B cell depletion for precision therapy of mucosal pemphigus vulgaris59
X chromosome dosage of histone demethylase KDM5C determines sex differences in adiposity59
TLR3 controls constitutive IFN-β antiviral immunity in human fibroblasts and cortical neurons59
Proinflammatory P2Y14 receptor inhibition protects against ischemic acute kidney injury in mice58
Bruton tyrosine kinase deficiency augments NLRP3 inflammasome activation and causes IL-1β–mediated colitis58
Oral N-acetylcysteine improves cone function in retinitis pigmentosa patients in phase I trial58
LIN28B promotes the development of neuroendocrine prostate cancer58
Chronic mTOR activation induces a degradative smooth muscle cell phenotype57
Age-related susceptibility to coronavirus infections: role of impaired and dysregulated host immunity57
Correction of muscular dystrophies by CRISPR gene editing57
Mesenchymal Bmp3b expression maintains skeletal muscle integrity and decreases in age-related sarcopenia56
Decreased adipose tissue oxygenation associates with insulin resistance in individuals with obesity56
Claudin-2 deficiency associates with hypercalciuria in mice and human kidney stone disease56
Multiomic analysis and immunoprofiling reveal distinct subtypes of human angiosarcoma55
Pathogenesis of peritumoral hyperexcitability in an immunocompetent CRISPR-based glioblastoma model55
Severe SARS-CoV-2 placenta infection can impact neonatal outcome in the absence of vertical transmission54
Immune pathogenesis of COVID-19–related multisystem inflammatory syndrome in children54
Brain immune cells undergo cGAS/STING-dependent apoptosis during herpes simplex virus type 1 infection to limit type I IFN production53
Oleic acid restores suppressive defects in tissue-resident FOXP3 Tregs from patients with multiple sclerosis53
Antibody responses to endemic coronaviruses modulate COVID-19 convalescent plasma functionality53
OX40+ plasmacytoid dendritic cells in the tumor microenvironment promote antitumor immunity53
MAL2 drives immune evasion in breast cancer by suppressing tumor antigen presentation53
GLS1-mediated glutaminolysis unbridled by MALT1 protease promotes psoriasis pathogenesis53
Peripheral host T cells survive hematopoietic stem cell transplantation and promote graft-versus-host disease53
YIPF5 mutations cause neonatal diabetes and microcephaly through endoplasmic reticulum stress52
NLRP3 inflammasome induces CD4+ T cell loss in chronically HIV-1–infected patients52
Prevention of connexin-43 remodeling protects against Duchenne muscular dystrophy cardiomyopathy51
Insight into next-generation CAR therapeutics: designing CAR T cells to improve clinical outcomes51
Bruton’s tyrosine kinase inhibition effectively protects against human IgE-mediated anaphylaxis51
SUMOylation promotes extracellular vesicle–mediated transmission of lncRNA ELNAT1 and lymph node metastasis in bladder cancer51
IL-36 in chronic inflammation and fibrosis — bridging the gap?51
Tendon-derived cathepsin K–expressing progenitor cells activate Hedgehog signaling to drive heterotopic ossification51
Defective lysosome reformation during autophagy causes skeletal muscle disease50
Type 1 diabetes mellitus: much progress, many opportunities50
Cx43 hemichannel microdomain signaling at the intercalated disc enhances cardiac excitability50
Senescent T cells within suppressive tumor microenvironments: emerging target for tumor immunotherapy50
BCL11A enhancer–edited hematopoietic stem cells persist in rhesus monkeys without toxicity50
GPR160 de-orphanization reveals critical roles in neuropathic pain in rodents50
Ovariectomy induces bone loss via microbial-dependent trafficking of intestinal TNF+ T cells and Th17 cells50