OOIR: Observatory of International Research

Papers

(The TQCC of Journal of Clinical Investigation is 56. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-12-01 to 2024-12-01.)

Article	Citations
Recent endemic coronavirus infection is associated with less-severe COVID-19	267
Insulin signaling in health and disease	226
SARS-CoV-2–specific CD8+ T cell responses in convalescent COVID-19 individuals	214
Renal tubule Cpt1a overexpression protects from kidney fibrosis by restoring mitochondrial homeostasis	188
Selective glutamine metabolism inhibition in tumor cells improves antitumor T lymphocyte activity in triple-negative breast cancer	174
TYRO3 induces anti–PD-1/PD-L1 therapy resistance by limiting innate immunity and tumoral ferroptosis	168
Long-term microstructure and cerebral blood flow changes in patients recovered from COVID-19 without neurological manifestations	166
Endothelial C3a receptor mediates vascular inflammation and blood-brain barrier permeability during aging	147
Immune dysregulation as a driver of idiopathic pulmonary fibrosis	142
Pharmacological treatment of hyperglycemia in type 2 diabetes	131
Radiotherapy-exposed CD8+ and CD4+ neoantigens enhance tumor control	130
ATM inhibition enhances cancer immunotherapy by promoting mtDNA leakage and cGAS/STING activation	128
Bone marrow adipogenic lineage precursors promote osteoclastogenesis in bone remodeling and pathologic bone loss	126
TREM2 sustains macrophage-hepatocyte metabolic coordination in nonalcoholic fatty liver disease and sepsis	125
Altered glycosylation of IgG4 promotes lectin complement pathway activation in anti-PLA2R1–associated membranous nephropathy	121
Circulating markers of NADH-reductive stress correlate with mitochondrial disease severity	118
Biomarkers of inflammation and repair in kidney disease progression	113
Antigen-driven clonal selection shapes the persistence of HIV-1–infected CD4+ T cells in vivo	111
Immune checkpoint inhibitor–associated myocarditis: manifestations and mechanisms	108
BCG vaccination history associates with decreased SARS-CoV-2 seroprevalence across a diverse cohort of health care workers	107
Dietary interventions for obesity: clinical and mechanistic findings	106
Impaired complex I repair causes recessive Leber’s hereditary optic neuropathy	105
Lung megakaryocytes are immune modulatory cells	103
Sustained cellular immune dysregulation in individuals recovering from SARS-CoV-2 infection	103
Transcriptome-directed analysis for Mendelian disease diagnosis overcomes limitations of conventional genomic testing	103

Similarities and differences between the immunopathogenesis of COVID-19–related pediatric multisystem inflammatory syndrome and Kawasaki disease	101
Monogenic diabetes: a gateway to precision medicine in diabetes	101
Age-determined expression of priming protease TMPRSS2 and localization of SARS-CoV-2 in lung epithelium	100
Overcoming innate immune barriers that impede AAV gene therapy vectors	98
The lung microenvironment shapes a dysfunctional response of alveolar macrophages in aging	96
Neutrophil-to-hepatocyte communication via LDLR-dependent miR-223–enriched extracellular vesicle transfer ameliorates nonalcoholic steatohepatitis	95
Functional monocytic myeloid-derived suppressor cells increase in blood but not airways and predict COVID-19 severity	89
Mesenchymal Bmp3b expression maintains skeletal muscle integrity and decreases in age-related sarcopenia	89
Hypoxia-inducible factor activity promotes antitumor effector function and tissue residency by CD8+ T cells	89
The knowns and unknowns of latent Mycobacterium tuberculosis infection	85
Fecal microbiome and metabolome differ in healthy and food-allergic twins	85
Gastrointestinal motility disorders in neurologic disease	83
Type 1 diabetes mellitus: much progress, many opportunities	80
SUMOylation promotes extracellular vesicle–mediated transmission of lncRNA ELNAT1 and lymph node metastasis in bladder cancer	76
Brain immune cells undergo cGAS/STING-dependent apoptosis during herpes simplex virus type 1 infection to limit type I IFN production	75
Inhibition of 2-hydroxyglutarate elicits metabolic reprogramming and mutant IDH1 glioma immunity in mice	75
IL-36 in chronic inflammation and fibrosis — bridging the gap?	74
Herpes simplex encephalitis in a patient with a distinctive form of inherited IFNAR1 deficiency	74
Durable SARS-CoV-2 B cell immunity after mild or severe disease	74
Gluconeogenic enzyme PCK1 deficiency promotes CHK2 O-GlcNAcylation and hepatocellular carcinoma growth upon glucose deprivation	73
MAL2 drives immune evasion in breast cancer by suppressing tumor antigen presentation	72
Lipid-induced endothelial vascular cell adhesion molecule 1 promotes nonalcoholic steatohepatitis pathogenesis	71
Bite of the wolf: innate immune responses propagate autoimmunity in lupus	70
TLR3 controls constitutive IFN-β antiviral immunity in human fibroblasts and cortical neurons	69
Clinical, laboratory, and temporal predictors of neutralizing antibodies against SARS-CoV-2 among COVID-19 convalescent plasma donor candidates	68
Neutrophil dynamics in the tumor microenvironment	66
NLRP3 inflammasome induces CD4+ T cell loss in chronically HIV-1–infected patients	65
Ovariectomy induces bone loss via microbial-dependent trafficking of intestinal TNF+ T cells and Th17 cells	64
Interferons in cancer immunoediting: sculpting metastasis and immunotherapy response	64
Pfs230 yields higher malaria transmission–blocking vaccine activity than Pfs25 in humans but not mice	63
Endoplasmic reticulum protein TXNDC5 promotes renal fibrosis by enforcing TGF-β signaling in kidney fibroblasts	62
PD-1 blockade improves Kupffer cell bacterial clearance in acute liver injury	62
Oleic acid restores suppressive defects in tissue-resident FOXP3 Tregs from patients with multiple sclerosis	62
Severe SARS-CoV-2 placenta infection can impact neonatal outcome in the absence of vertical transmission	62
Defective lysosome reformation during autophagy causes skeletal muscle disease	61
Antibody responses to endemic coronaviruses modulate COVID-19 convalescent plasma functionality	60
Insight into next-generation CAR therapeutics: designing CAR T cells to improve clinical outcomes	59
CCR5-edited CD4+ T cells augment HIV-specific immunity to enable post-rebound control of HIV replication	58
N-cadherin upregulation mediates adaptive radioresistance in glioblastoma	57
Macrophage AXL receptor tyrosine kinase inflames the heart after reperfused myocardial infarction	57
17β-estradiol and estrogen receptor α protect right ventricular function in pulmonary hypertension via BMPR2 and apelin	56