OOIR: Observatory of International Research

Papers

(The median citation count of Journal of Clinical Investigation is 31. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-01-01 to 2025-01-01.)

Article	Citations
Gastrointestinal motility disorders in neurologic disease	267
The vascular landscape of human cancer	226
ABO blood type: a window into the genetics of acute respiratory distress syndrome susceptibility	214
Targeting the mutant p53 secretome	188
Changes in the National Cancer Institute’s R01 workforce: growth, aging, retention, and policy implications	188
Age-specific effects of vaccine egg adaptation and immune priming on A(H3N2) antibody responses following influenza vaccination	168
Herpes simplex encephalitis in a patient with a distinctive form of inherited IFNAR1 deficiency	166
NOD2 drives early IL-33–dependent expansion of group 2 innate lymphoid cells during Crohn’s disease–like ileitis	150
Epigenetic reprogramming to prevent genetic cardiomyopathy	142
Prolonged adaptive immune activation in COVID-19: implications for maintenance of long-term immunity?	140
An abundant biliary metabolite derived from dietary omega-3 polyunsaturated fatty acids regulates triglycerides	131
Propranolol inhibits cavernous vascular malformations by β1 adrenergic receptor antagonism in animal models	128
Paracardial fat and vitamin A: a mechanism for regulating exercise performance	126
Identification of SARS-CoV-2–specific immune alterations in acutely ill patients	125
Research gaps in medical treatment of transgender/nonbinary people	121
VCAM-1: closing the gap between lipotoxicity and endothelial dysfunction in nonalcoholic steatohepatitis	119
Plasma cells promote osteoclastogenesis and periarticular bone loss in autoimmune arthritis	118
Selective glutamine metabolism inhibition in tumor cells improves antitumor T lymphocyte activity in triple-negative breast cancer	113
Targeting the mitochondrial trifunctional protein restrains tumor growth in oxidative lung carcinomas	111
Interferons in cancer immunoediting: sculpting metastasis and immunotherapy response	108
Testosterone replacement in aging men: an evidence-based patient-centric perspective	107
Insight into next-generation CAR therapeutics: designing CAR T cells to improve clinical outcomes	107
Residual β cell function in long-term type 1 diabetes associates with reduced incidence of hypoglycemia	103
Immune MAL2-practice: breast cancer immunoevasion via MHC class I degradation	103
A sobering addition to the literature on COVID-19 and the brain	103

CC17 group B Streptococcus exploits integrins for neonatal meningitis development	101
Remodeling glycerophospholipids affects obesity-related insulin signaling in skeletal muscle	101
Combined immunodeficiency due to a mutation in the γ1 subunit of the coat protein I complex	100
Lysophospholipid acylation modulates plasma membrane lipid organization and insulin sensitivity in skeletal muscle	98
Targeting a Braf/Mapk pathway rescues podocyte lipid peroxidation in CoQ-deficiency kidney disease	96
Inhibiting the MNK1/2-eIF4E axis impairs melanoma phenotype switching and potentiates antitumor immune responses	95
IRF3 reduces adipose thermogenesis via ISG15-mediated reprogramming of glycolysis	89
A replication-competent adenovirus-vectored influenza vaccine induces durable systemic and mucosal immunity	89
TREM2 sustains macrophage-hepatocyte metabolic coordination in nonalcoholic fatty liver disease and sepsis	89
Lung megakaryocytes are immune modulatory cells	85
SUMOylation promotes extracellular vesicle–mediated transmission of lncRNA ELNAT1 and lymph node metastasis in bladder cancer	85
Brain immune cells undergo cGAS/STING-dependent apoptosis during herpes simplex virus type 1 infection to limit type I IFN production	83
Renal tubule Cpt1a overexpression protects from kidney fibrosis by restoring mitochondrial homeostasis	83
Neutrophil-to-hepatocyte communication via LDLR-dependent miR-223–enriched extracellular vesicle transfer ameliorates nonalcoholic steatohepatitis	80
Aberrant AZIN2 and polyamine metabolism precipitates tau neuropathology	76
Integrating imaging and RNA-seq improves outcome prediction in cervical cancer	75
Endoplasmic reticulum stress sensor IRE1α propels neutrophil hyperactivity in lupus	74
The use of observational research to inform clinical practice	74
Paracardial fat remodeling affects systemic metabolism through alcohol dehydrogenase 1	74
Bone marrow niche ATP levels determine leukemia-initiating cell activity via P2X7 in leukemic models	73
Muscle Krüppel-like factor 15 regulates lipid flux and systemic metabolic homeostasis	72
Uridine diphosphate–glucose/P2Y14R axis is a nonchemokine pathway that selectively promotes eosinophil accumulation	71
Chemical pancreatectomy treats chronic pancreatitis while preserving endocrine function in preclinical models	70
Lymphohematopoietic graft-versus-host responses promote mixed chimerism in patients receiving intestinal transplantation	69
Satellite glial GPR37L1 and its ligand maresin 1 regulate potassium channel signaling and pain homeostasis	68
Cyclin A2 maintains colon homeostasis and is a prognostic factor in colorectal cancer	67
America’s deadly flirtation with antiscience and the medical freedom movement	66
The power of two: lessons from a scientific partnership	65
A conversation with Robert Lefkowitz	65
The JCI Scholar experience strengthens physician-scientist training	64
Proteomic and metabolomic advances uncover biomarkers of mitochondrial disease pathophysiology and severity	63
Keeping the peace: commensal Cutibacterium acnes trains CD4+ TH17 cells to trap and kill	62
Long-term microstructure and cerebral blood flow changes in patients recovered from COVID-19 without neurological manifestations	62
Battle for supremacy: nucleic acid interactions between viruses and cells	62
Metabolic rerouting via SCD1 induction impacts X-linked adrenoleukodystrophy	61
Bite of the wolf: innate immune responses propagate autoimmunity in lupus	60
Oxidized CaMKII and O-GlcNAcylation cause increased atrial fibrillation in diabetic mice by distinct mechanisms	59
ANGPTL2-containing small extracellular vesicles from vascular endothelial cells accelerate leukemia progression	58
BCL6 confers KRAS-mutant non–small-cell lung cancer resistance to BET inhibitors	57
Severe insulin resistance syndromes	57
BCG vaccination history associates with decreased SARS-CoV-2 seroprevalence across a diverse cohort of health care workers	57
Concerted roles of PTEN and ATM in controlling hematopoietic stem cell fitness and dormancy	56
Endoplasmic reticulum–associated degradation is required for nephrin maturation and kidney glomerular filtration function	55
TLR3 controls constitutive IFN-β antiviral immunity in human fibroblasts and cortical neurons	55
A CRISPR view of the 2020 Nobel Prize in Chemistry	53
TorsinA restoration in a mouse model identifies a critical therapeutic window for DYT1 dystonia	52
YAP/TFEB pathway promotes autophagic cell death and hypertrophic cardiomyopathy in lysosomal storage diseases	52
RUNX2 regulates leukemic cell metabolism and chemotaxis in high-risk T cell acute lymphoblastic leukemia	51
Guanosine triphosphate links MYC-dependent metabolic and ribosome programs in small-cell lung cancer	51
Location is everything when it comes to megakaryocyte function	51

Computerized tumor multinucleation index (MuNI) is prognostic in p16+ oropharyngeal carcinoma	51
Extracellular traps released by antimicrobial TH17 cells contribute to host defense	50
Neutrophilic inflammation during lung development disrupts elastin assembly and predisposes adult mice to COPD	49
Ovariectomy induces bone loss via microbial-dependent trafficking of intestinal TNF+ T cells and Th17 cells	49
Hypothalamic REV-ERB nuclear receptors control diurnal food intake and leptin sensitivity in diet-induced obese mice	49
ATM inhibition enhances cancer immunotherapy by promoting mtDNA leakage and cGAS/STING activation	48
UDP-glucose and P2Y14 receptor amplify allergen-induced airway eosinophilia	48
Galectin-7 downregulation in lesional keratinocytes contributes to enhanced IL-17A signaling and skin pathology in psoriasis	48
IL-36 in chronic inflammation and fibrosis — bridging the gap?	47
The ABO histo-blood group, endothelial activation, and acute respiratory distress syndrome risk in critical illness	46
CD8+ T cells fail to limit SIV reactivation following ART withdrawal until after viral amplification	45
Blood-brain barrier resealing in neuromyelitis optica occurs independently of astrocyte regeneration	43
Deubiquitinase USP7 contributes to the pathogenicity of spinal and bulbar muscular atrophy	43
Somatic reversion of pathogenic DOCK8 variants alters lymphocyte differentiation and function to effectively cure DOCK8 deficiency	43
Human skin is colonized by T cells that recognize CD1a independently of lipid	43
Correction of vasopressin deficit in the lateral septum ameliorates social deficits of mouse autism model	42
A clear pathway to tubulointerstitial disease: is an exclusive focus on fibrosis justified?	42
Adenosine A3 agonists reverse neuropathic pain via T cell–mediated production of IL-10	42
Functional monocytic myeloid-derived suppressor cells increase in blood but not airways and predict COVID-19 severity	41
Pfs230 yields higher malaria transmission–blocking vaccine activity than Pfs25 in humans but not mice	41
The whole is greater than the sum of the parts	40
Benjamin Ebert wins the 2021 ASCI/Stanley J. Korsmeyer Award	40
Chemical pancreatectomy: an unconventional approach to preventing autodigestion in pancreatitis	40
ALS-associated mutation FUS-R521C causes DNA damage and RNA splicing defects	39
Triglyceride lowering by omega-3 fatty acids: a mechanism mediated by N-acyl taurines	39
Emergency seed funding for COVID-19 research: lessons from Johns Hopkins University	39
A tribute to John G. Bartlett, MD (1937–2021)	39
Dysbiosis in food allergy and implications for microbial therapeutics	39
Overcoming innate immune barriers that impede AAV gene therapy vectors	38
RNF168 regulates R-loop resolution and genomic stability in BRCA1/2-deficient tumors	38
Graft-versus-host disease depletes plasmacytoid dendritic cell progenitors to impair tolerance induction	38
Endothelium-derived semaphorin 3G attenuates ischemic retinopathy by coordinating β-catenin–dependent vascular remodeling	38
Myeloid cell–targeted STAT3 inhibition sensitizes head and neck cancers to radiotherapy and T cell–mediated immunity	37
Generating evidence for therapeutic effects: the need for well-conducted randomized trials	37
Hypoxia-inducible factor activity promotes antitumor effector function and tissue residency by CD8+ T cells	37
Mitigating oxygen stress enhances aged mouse hematopoietic stem cell numbers and function	37
ER-to-Golgi transport and SEC23-dependent COPII vesicles regulate T cell alloimmunity	36
Protein tyrosine phosphatase nonreceptor type 2 controls colorectal cancer development	36
Dysregulation of the NRG1/ERBB pathway causes a developmental disorder with gastrointestinal dysmotility in humans	36
CMV viral load kinetics as surrogate endpoints after allogeneic transplantation	35
The loss-of-function PCSK9Q152H variant increases ER chaperones GRP78 and GRP94 and protects against liver injury	35
Bardet-Biedl syndrome proteins regulate intracellular signaling and neuronal function in patient-specific iPSC-derived neurons	35
17β-estradiol and estrogen receptor α protect right ventricular function in pulmonary hypertension via BMPR2 and apelin	35
The knowns and unknowns of latent Mycobacterium tuberculosis infection	34
Turbinmicin inhibits Candida biofilm growth by disrupting fungal vesicle–mediated trafficking	34
Inhibition of relaxin autocrine signaling confers therapeutic vulnerability in ovarian cancer	34
Transcriptome-directed analysis for Mendelian disease diagnosis overcomes limitations of conventional genomic testing	33
Altered glycosylation of IgG4 promotes lectin complement pathway activation in anti-PLA2R1–associated membranous nephropathy	33
TREM-1 orchestrates angiotensin II–induced monocyte trafficking and promotes experimental abdominal aortic aneurysm	33
Dynamic single-cell RNA sequencing identifies immunotherapy persister cells following PD-1 blockade	33
Hyperglycemia cooperates with Tet2 heterozygosity to induce leukemia driven by proinflammatory cytokine–induced lncRNA Morrbid	33
Apobec1 complementation factor overexpression promotes hepatic steatosis, fibrosis, and hepatocellular cancer	32
Lipid-induced endothelial vascular cell adhesion molecule 1 promotes nonalcoholic steatohepatitis pathogenesis	32
Type 1 diabetes mellitus: much progress, many opportunities	32
Tetracyclines improve experimental lymphatic filariasis pathology by disrupting interleukin-4 receptor–mediated lymphangiogenesis	31
Early T follicular helper cell activity accelerates hepatitis C virus-specific B cell expansion	31
Severe SARS-CoV-2 placenta infection can impact neonatal outcome in the absence of vertical transmission	31
Genomic variants within chromosome 14q32.32 regulate bone mass through MARK3 signaling in osteoblasts	31
YAP plays a crucial role in the development of cardiomyopathy in lysosomal storage diseases	31
Transient telomere dysfunction induces chromosomal instability and promotes carcinogenesis	31
NLRP3 inflammasome induces CD4+ T cell loss in chronically HIV-1–infected patients	31
Identification of human long noncoding RNAs associated with nonalcoholic fatty liver disease and metabolic homeostasis	31
APC-activated long noncoding RNA inhibits colorectal carcinoma pathogenesis through reduction of exosome production	31
MAL2 drives immune evasion in breast cancer by suppressing tumor antigen presentation	31