Journal of Clinical Investigation

Article	Citations
Clinical and immunological features of severe and moderate coronavirus disease 2019	3496
SARS-CoV-2: a storm is raging	869
Deployment of convalescent plasma for the prevention and treatment of COVID-19	581
Complement and tissue factor–enriched neutrophil extracellular traps are key drivers in COVID-19 immunothrombosis	551
Kinetics of viral load and antibody response in relation to COVID-19 severity	460
Impaired immune cell cytotoxicity in severe COVID-19 is IL-6 dependent	400
Immune responses to stroke: mechanisms, modulation, and therapeutic potential	344
SARS–CoV-2 infection of the placenta	338
Sex, age, and hospitalization drive antibody responses in a COVID-19 convalescent plasma donor population	334
Multisystem inflammatory syndrome in children and COVID-19 are distinct presentations of SARS–CoV-2	296
Early safety indicators of COVID-19 convalescent plasma in 5000 patients	293
Distinct clinical and immunological features of SARS–CoV-2–induced multisystem inflammatory syndrome in children	275
Recent endemic coronavirus infection is associated with less-severe COVID-19	254
Targeting glutamine metabolism enhances tumor-specific immunity by modulating suppressive myeloid cells	223
mRNA vaccine–induced neoantigen-specific T cell immunity in patients with gastrointestinal cancer	216
SARS-CoV-2–specific CD8+ T cell responses in convalescent COVID-19 individuals	199
Baricitinib restrains the immune dysregulation in patients with severe COVID-19	195
Targeting tumor-associated macrophages and granulocytic myeloid-derived suppressor cells augments PD-1 blockade in cholangiocarcinoma	181
Insulin signaling in health and disease	175
SARS–CoV-2–specific T cell responses and correlations with COVID-19 patient predisposition	172
HIFs, angiogenesis, and metabolism: elusive enemies in breast cancer	170
Convalescent plasma anti–SARS-CoV-2 spike protein ectodomain and receptor-binding domain IgG correlate with virus neutralization	162
Immune escape and immunotherapy of acute myeloid leukemia	157
COVID-19 severity associates with pulmonary redistribution of CD1c+ DCs and inflammatory transitional and nonclassical monocytes	156
Renal tubule Cpt1a overexpression protects from kidney fibrosis by restoring mitochondrial homeostasis	144

Selective glutamine metabolism inhibition in tumor cells improves antitumor T lymphocyte activity in triple-negative breast cancer	142
Long-term microstructure and cerebral blood flow changes in patients recovered from COVID-19 without neurological manifestations	137
Impact of TREM2R47H variant on tau pathology–induced gliosis and neurodegeneration	136
Contributions of alveolar epithelial cell quality control to pulmonary fibrosis	135
A tumor-intrinsic PD-L1/NLRP3 inflammasome signaling pathway drives resistance to anti–PD-1 immunotherapy	134
TYRO3 induces anti–PD-1/PD-L1 therapy resistance by limiting innate immunity and tumoral ferroptosis	132
Herpesvirus latency	127
Hypoxia-inducible factors and obstructive sleep apnea	127
Peripheral CD4+ T cell subsets and antibody response in COVID-19 convalescent individuals	123
Truncated stathmin-2 is a marker of TDP-43 pathology in frontotemporal dementia	119
Boosting NAD level suppresses inflammatory activation of PBMCs in heart failure	117
TRPV4 channel opening mediates pressure-induced pancreatitis initiated by Piezo1 activation	117
IL-17 and immunologically induced senescence regulate response to injury in osteoarthritis	117
Urine DNA methylation assay enables early detection and recurrence monitoring for bladder cancer	112
Endothelial C3a receptor mediates vascular inflammation and blood-brain barrier permeability during aging	111
IL-1β suppression of VE-cadherin transcription underlies sepsis-induced inflammatory lung injury	111
The COVID-19 pandemic and research shutdown: staying safe and productive	111
Immune dysregulation as a driver of idiopathic pulmonary fibrosis	109
Single residue in CD28-costimulated CAR-T cells limits long-term persistence and antitumor durability	109
p53/microRNA-214/ULK1 axis impairs renal tubular autophagy in diabetic kidney disease	109
Circular RNA-ZNF532 regulates diabetes-induced retinal pericyte degeneration and vascular dysfunction	108
Epigenetic driver mutations in ARID1A shape cancer immune phenotype and immunotherapy	108
Radiotherapy-exposed CD8+ and CD4+ neoantigens enhance tumor control	108
Bile acid metabolism is altered in multiple sclerosis and supplementation ameliorates neuroinflammation	107
IRF4 instructs effector Treg differentiation and immune suppression in human cancer	106
Cytotoxic CD4+ T lymphocytes may induce endothelial cell apoptosis in systemic sclerosis	105
Hypoxia-inducible factor signaling in pulmonary hypertension	103
TREM2 sustains macrophage-hepatocyte metabolic coordination in nonalcoholic fatty liver disease and sepsis	103
Pharmacological treatment of hyperglycemia in type 2 diabetes	102
Antigen-driven clonal selection shapes the persistence of HIV-1–infected CD4+ T cells in vivo	101
ATM inhibition enhances cancer immunotherapy by promoting mtDNA leakage and cGAS/STING activation	101
HDAC inhibitors elicit metabolic reprogramming by targeting super-enhancers in glioblastoma models	100
BCG vaccination history associates with decreased SARS-CoV-2 seroprevalence across a diverse cohort of health care workers	100
Sleeping Beauty–engineered CAR T cells achieve antileukemic activity without severe toxicities	98
Bone marrow adipogenic lineage precursors promote osteoclastogenesis in bone remodeling and pathologic bone loss	98
Microenvironmental Th9 and Th17 lymphocytes induce metastatic spreading in lung cancer	97
Favorable outcomes of COVID-19 in recipients of hematopoietic cell transplantation	97
Melatonin inhibits cytosolic mitochondrial DNA–induced neuroinflammatory signaling in accelerated aging and neurodegeneration	97
Age-determined expression of priming protease TMPRSS2 and localization of SARS-CoV-2 in lung epithelium	96
Preventing cytokine storm syndrome in COVID-19 using α-1 adrenergic receptor antagonists	96
Sustained cellular immune dysregulation in individuals recovering from SARS-CoV-2 infection	94
Osteocyte necrosis triggers osteoclast-mediated bone loss through macrophage-inducible C-type lectin	93
Circadian rhythm influences induction of trained immunity by BCG vaccination	93
Biomarkers of inflammation and repair in kidney disease progression	93
Altered glycosylation of IgG4 promotes lectin complement pathway activation in anti-PLA2R1–associated membranous nephropathy	92
BCG vaccination in humans inhibits systemic inflammation in a sex-dependent manner	92
Lung megakaryocytes are immune modulatory cells	92
Similarities and differences between the immunopathogenesis of COVID-19–related pediatric multisystem inflammatory syndrome and Kawasaki disease	92
Circulating markers of NADH-reductive stress correlate with mitochondrial disease severity	91
Minimal PD-1 expression in mouse and human NK cells under diverse conditions	90

COVID-19 threatens health systems in sub-Saharan Africa: the eye of the crocodile	88
COVID-19 survival associates with the immunoglobulin response to the SARS-CoV-2 spike receptor binding domain	88
PD-1 blockade inhibits osteoclast formation and murine bone cancer pain	88
Inherited human IFN-γ deficiency underlies mycobacterial disease	87
Inhibition of mitophagy drives macrophage activation and antibacterial defense during sepsis	86
HIV-1 viremia not suppressible by antiretroviral therapy can originate from large T cell clones producing infectious virus	85
Corticosteroid treatment in severe COVID-19 patients with acute respiratory distress syndrome	85
Hypoxia-inducible factors and innate immunity in liver cancer	85
Functional monocytic myeloid-derived suppressor cells increase in blood but not airways and predict COVID-19 severity	85
Upregulation of Rubicon promotes autosis during myocardial ischemia/reperfusion injury	85
Impaired complex I repair causes recessive Leber’s hereditary optic neuropathy	85
Transcriptome-directed analysis for Mendelian disease diagnosis overcomes limitations of conventional genomic testing	83
S100A8/A9 regulates CD11b expression and neutrophil recruitment during chronic tuberculosis	82
Immune checkpoint inhibitor–associated myocarditis: manifestations and mechanisms	82
Clinical trials for COVID-19 should include sex as a variable	80
The lung microenvironment shapes a dysfunctional response of alveolar macrophages in aging	80
Dietary interventions for obesity: clinical and mechanistic findings	78
Exebacase for patients with Staphylococcus aureus bloodstream infection and endocarditis	78
Hypoxia-inducible factors and diabetes	77
Pancreatic ductal adenocarcinoma progression is restrained by stromal matrix	77
TGF-β–induced epigenetic deregulation of SOCS3 facilitates STAT3 signaling to promote fibrosis	76
Monogenic diabetes: a gateway to precision medicine in diabetes	76
BCL-2 antagonism sensitizes cytotoxic T cell–resistant HIV reservoirs to elimination ex vivo	76
Pembrolizumab plus allogeneic NK cells in advanced non–small cell lung cancer patients	75
State of the art in CAR T cell therapy for CD19+ B cell malignancies	75
Neutrophil-to-hepatocyte communication via LDLR-dependent miR-223–enriched extracellular vesicle transfer ameliorates nonalcoholic steatohepatitis	75
Inactivation of paracellular cation-selective claudin-2 channels attenuates immune-mediated experimental colitis in mice	74
Muscle-derived interleukin 6 increases exercise capacity by signaling in osteoblasts	74
Healthy donor T cell responses to common cold coronaviruses and SARS-CoV-2	73
Overcoming innate immune barriers that impede AAV gene therapy vectors	73
Stiff stroma increases breast cancer risk by inducing the oncogene ZNF217	72
Inhibition of the ATM/Chk2 axis promotes cGAS/STING signaling in ARID1A-deficient tumors	71
Chemotherapy-induced S100A10 recruits KDM6A to facilitate OCT4-mediated breast cancer stemness	70
Durable SARS-CoV-2 B cell immunity after mild or severe disease	70
Longitudinal study reveals HIV-1–infected CD4+ T cell dynamics during long-term antiretroviral therapy	69
DCAF1 regulates Treg senescence via the ROS axis during immunological aging	69
Mass cytometry detects H3.3K27M-specific vaccine responses in diffuse midline glioma	69
Fecal microbiome and metabolome differ in healthy and food-allergic twins	69
Inflammatory syndromes associated with SARS-CoV-2 infection: dysregulation of the immune response across the age spectrum	69
Inhibition of 2-hydroxyglutarate elicits metabolic reprogramming and mutant IDH1 glioma immunity in mice	68
Gastrointestinal motility disorders in neurologic disease	68
Complementopathies and precision medicine	68
The knowns and unknowns of latent Mycobacterium tuberculosis infection	66
Hypoxia-inducible factor activity promotes antitumor effector function and tissue residency by CD8+ T cells	66
Mesenchymal Bmp3b expression maintains skeletal muscle integrity and decreases in age-related sarcopenia	66
Herpes simplex encephalitis in a patient with a distinctive form of inherited IFNAR1 deficiency	65
Sensory nerves regulate mesenchymal stromal cell lineage commitment by tuning sympathetic tones	65
Clinical, laboratory, and temporal predictors of neutralizing antibodies against SARS-CoV-2 among COVID-19 convalescent plasma donor candidates	65
Antigen-specific B cell depletion for precision therapy of mucosal pemphigus vulgaris	64
New York City COVID-19 resident physician exposure during exponential phase of pandemic	64
TLR3 controls constitutive IFN-β antiviral immunity in human fibroblasts and cortical neurons	64
Kidney diseases in the time of COVID-19: major challenges to patient care	63
B cell–intrinsic TLR9 expression is protective in murine lupus	62
Exosomes mediate sensory hair cell protection in the inner ear	62
LIN28B promotes the development of neuroendocrine prostate cancer	61
Decreased adipose tissue oxygenation associates with insulin resistance in individuals with obesity	61
X chromosome dosage of histone demethylase KDM5C determines sex differences in adiposity	61
Severe SARS-CoV-2 placenta infection can impact neonatal outcome in the absence of vertical transmission	61
Correction of muscular dystrophies by CRISPR gene editing	60
SUMOylation promotes extracellular vesicle–mediated transmission of lncRNA ELNAT1 and lymph node metastasis in bladder cancer	60
dmPFC-vlPAG projection neurons contribute to pain threshold maintenance and antianxiety behaviors	59
Brain immune cells undergo cGAS/STING-dependent apoptosis during herpes simplex virus type 1 infection to limit type I IFN production	59
Age-related susceptibility to coronavirus infections: role of impaired and dysregulated host immunity	59
Proinflammatory P2Y14 receptor inhibition protects against ischemic acute kidney injury in mice	59
IL-36 in chronic inflammation and fibrosis — bridging the gap?	59
MAL2 drives immune evasion in breast cancer by suppressing tumor antigen presentation	58
Type 1 diabetes mellitus: much progress, many opportunities	58
Multiomic analysis and immunoprofiling reveal distinct subtypes of human angiosarcoma	58
GLS1-mediated glutaminolysis unbridled by MALT1 protease promotes psoriasis pathogenesis	57
Stem cell therapy for muscular dystrophies	56
YIPF5 mutations cause neonatal diabetes and microcephaly through endoplasmic reticulum stress	56
Pathogenesis of peritumoral hyperexcitability in an immunocompetent CRISPR-based glioblastoma model	56
NLRP3 inflammasome induces CD4+ T cell loss in chronically HIV-1–infected patients	56
Defective lysosome reformation during autophagy causes skeletal muscle disease	55
GPR160 de-orphanization reveals critical roles in neuropathic pain in rodents	55
Immune pathogenesis of COVID-19–related multisystem inflammatory syndrome in children	55
Lipid-induced endothelial vascular cell adhesion molecule 1 promotes nonalcoholic steatohepatitis pathogenesis	55
BCL11A enhancer–edited hematopoietic stem cells persist in rhesus monkeys without toxicity	54
OX40+ plasmacytoid dendritic cells in the tumor microenvironment promote antitumor immunity	54
Antibody responses to endemic coronaviruses modulate COVID-19 convalescent plasma functionality	54

Insight into next-generation CAR therapeutics: designing CAR T cells to improve clinical outcomes	54
Bite of the wolf: innate immune responses propagate autoimmunity in lupus	54
Peripheral host T cells survive hematopoietic stem cell transplantation and promote graft-versus-host disease	53
Endoplasmic reticulum protein TXNDC5 promotes renal fibrosis by enforcing TGF-β signaling in kidney fibroblasts	53
Oleic acid restores suppressive defects in tissue-resident FOXP3 Tregs from patients with multiple sclerosis	53
Bruton’s tyrosine kinase inhibition effectively protects against human IgE-mediated anaphylaxis	53
Gluconeogenic enzyme PCK1 deficiency promotes CHK2 O-GlcNAcylation and hepatocellular carcinoma growth upon glucose deprivation	53
Neutrophil dynamics in the tumor microenvironment	52
Post-sepsis immunosuppression depends on NKT cell regulation of mTOR/IFN-γ in NK cells	52
Kisspeptin receptor agonist has therapeutic potential for female reproductive disorders	52
Ovariectomy induces bone loss via microbial-dependent trafficking of intestinal TNF+ T cells and Th17 cells	52
Sel1L-Hrd1 ER-associated degradation maintains β cell identity via TGF-β signaling	52
Tendon-derived cathepsin K–expressing progenitor cells activate Hedgehog signaling to drive heterotopic ossification	52
Selective SIRPα blockade reverses tumor T cell exclusion and overcomes cancer immunotherapy resistance	51
Cx43 hemichannel microdomain signaling at the intercalated disc enhances cardiac excitability	51
CCR5-edited CD4+ T cells augment HIV-specific immunity to enable post-rebound control of HIV replication	50
Parkin ubiquitinates phosphoglycerate dehydrogenase to suppress serine synthesis and tumor progression	50
Specificity of bispecific T cell receptors and antibodies targeting peptide-HLA	50
Thioredoxin activity confers resistance against oxidative stress in tumor-infiltrating NK cells	50
Diagnostic accuracy of 3 urine lipoarabinomannan tuberculosis assays in HIV-negative outpatients	50
PD-1 blockade improves Kupffer cell bacterial clearance in acute liver injury	50
FGFR4 regulates tumor subtype differentiation in luminal breast cancer and metastatic disease	50
SARS-CoV-2 viral load and antibody responses: the case for convalescent plasma therapy	50
Long noncoding RNA H19X is a key mediator of TGF-β–driven fibrosis	50
Maintenance DNA methylation is essential for regulatory T cell development and stability of suppressive function	49
The multifaceted nature of HIV latency	49
γ9δ2T cell diversity and the receptor interface with tumor cells	49
Interferons in cancer immunoediting: sculpting metastasis and immunotherapy response	48
Mesenchymal niche remodeling impairs hematopoiesis via stanniocalcin 1 in acute myeloid leukemia	48
The molecular biology and immune control of chronic Toxoplasma gondii infection	48
DYRK1A regulates B cell acute lymphoblastic leukemia through phosphorylation of FOXO1 and STAT3	47
Pfs230 yields higher malaria transmission–blocking vaccine activity than Pfs25 in humans but not mice	47
SARS-CoV-2 variants and convalescent plasma: reality, fallacies, and opportunities	47
Caspase-11–mediated enteric neuronal pyroptosis underlies Western diet–induced colonic dysmotility	46
Inhibition of IRF5 hyperactivation protects from lupus onset and severity	46
COVID-19, microangiopathy, hemostatic activation, and complement	46
Brain-specific repression of AMPKα1 alleviates pathophysiology in Alzheimer’s model mice	46
DNA hypermethylation during tuberculosis dampens host immune responsiveness	46
Mitochondrial dysfunction in inflammatory bowel disease alters intestinal epithelial metabolism of hepatic acylcarnitines	46
Epithelial-derived gasdermin D mediates nonlytic IL-1β release during experimental colitis	46
Gs/Gq signaling switch in β cells defines incretin effectiveness in diabetes	46
CBFB-MYH11 fusion neoantigen enables T cell recognition and killing of acute myeloid leukemia	45
Arginase impedes the resolution of colitis by altering the microbiome and metabolome	45
S1PR4 ablation reduces tumor growth and improves chemotherapy via CD8+ T cell expansion	45
Congenital heart disease risk loci identified by genome-wide association study in European patients	45
Corticosteroids, COVID-19 pneumonia, and acute respiratory distress syndrome	45
Influence of adiposity, insulin resistance, and intrahepatic triglyceride content on insulin kinetics	45
Macrophage AXL receptor tyrosine kinase inflames the heart after reperfused myocardial infarction	45
IL-17–producing γδ T cells protect against Clostridium difficile infection	45
T follicular regulatory cells and IL-10 promote food antigen–specific IgE	45
Selective expansion of regulatory T cells using an orthogonal IL-2/IL-2 receptor system facilitates transplantation tolerance	44
Adenosine A3 agonists reverse neuropathic pain via T cell–mediated production of IL-10	44
PRICKLE3 linked to ATPase biogenesis manifested Leber’s hereditary optic neuropathy	43
Human NK cell deficiency as a result of biallelic mutations in MCM10	43
Metabolic effects of air pollution exposure and reversibility	43
Myofibroblast contraction is essential for generating and regenerating the gas-exchange surface	43
Transcriptional and cytopathological hallmarks of FSHD in chronic DUX4-expressing mice	43
β-Glucan–induced reprogramming of human macrophages inhibits NLRP3 inflammasome activation in cryopyrinopathies	43
Antihypoxic oxygenation agents with respiratory hyperoxia to improve cancer immunotherapy	43
17β-estradiol and estrogen receptor α protect right ventricular function in pulmonary hypertension via BMPR2 and apelin	42
Dengue virus induces PCSK9 expression to alter antiviral responses and disease outcomes	42
Neuronal uptake transporters contribute to oxaliplatin neurotoxicity in mice	42
Salt generates antiinflammatory Th17 cells but amplifies pathogenicity in proinflammatory cytokine microenvironments	42
IRF3 reduces adipose thermogenesis via ISG15-mediated reprogramming of glycolysis	42
H. pylori infection alters repair of DNA double-strand breaks via SNHG17	42
Bone marrow niche ATP levels determine leukemia-initiating cell activity via P2X7 in leukemic models	42
N-cadherin upregulation mediates adaptive radioresistance in glioblastoma	42
Parental metabolic syndrome epigenetically reprograms offspring hepatic lipid metabolism in mice	41
Mapping mania symptoms based on focal brain damage	41
Neutrophilic inflammation during lung development disrupts elastin assembly and predisposes adult mice to COPD	41
TET repression and increased DNMT activity synergistically induce aberrant DNA methylation	41
Myeloid cell–targeted STAT3 inhibition sensitizes head and neck cancers to radiotherapy and T cell–mediated immunity	41
Residual β cell function in long-term type 1 diabetes associates with reduced incidence of hypoglycemia	41
Erythrocyte-derived microvesicles induce arterial spasms in JAK2V617F myeloproliferative neoplasm	41
Oxidized CaMKII and O-GlcNAcylation cause increased atrial fibrillation in diabetic mice by distinct mechanisms	41
Normal and defective pathways in biogenesis and maintenance of the insulin storage pool	40
Myeloid signature reveals immune contexture and predicts the prognosis of hepatocellular carcinoma	40
Turning lead into gold: reprogramming retinal cells to cure blindness	39
Tissue-resident T cell–derived cytokines eliminate herpes simplex virus-2–infected cells	39
Nitric oxide modulates bone anabolism through regulation of osteoblast glycolysis and differentiation	39
Humanized neurofibroma model from induced pluripotent stem cells delineates tumor pathogenesis and developmental origins	39
Immobilization after injury alters extracellular matrix and stem cell fate	39
Krabbe disease successfully treated via monotherapy of intrathecal gene therapy	39
Graft IL-33 regulates infiltrating macrophages to protect against chronic rejection	39
Epicutaneous Staphylococcus aureus induces IL-36 to enhance IgE production and ensuing allergic disease	39
Macrophage SR-BI modulates autophagy via VPS34 complex and PPARα transcription of Tfeb in atherosclerosis	39
Atypical cadherin FAT4 orchestrates lymphatic endothelial cell polarity in response to flow	39
Everolimus improves the efficacy of dasatinib in PDGFRα-driven glioma	39
Orally bioavailable CDK9/2 inhibitor shows mechanism-based therapeutic potential in MYCN-driven neuroblastoma	39
mTOR-dependent translation amplifies microglia priming in aging mice	39
Diminished hepatic IFN response following HCV clearance triggers HBV reactivation in coinfection	38
Auxiliary trafficking subunit GJA1-20k protects connexin-43 from degradation and limits ventricular arrhythmias	38
Respiratory syncytial virus infection exacerbates pneumococcal pneumonia via Gas6/Axl-mediated macrophage polarization	38
Maternal high-fat diet during lactation reprograms the dopaminergic circuitry in mice	38
RNF168 regulates R-loop resolution and genomic stability in BRCA1/2-deficient tumors	37