Journal of Clinical Investigation

Article	Citations
Recent endemic coronavirus infection is associated with less-severe COVID-19	267
SARS-CoV-2–specific CD8+ T cell responses in convalescent COVID-19 individuals	214
Insulin signaling in health and disease	212
Baricitinib restrains the immune dysregulation in patients with severe COVID-19	202
Renal tubule Cpt1a overexpression protects from kidney fibrosis by restoring mitochondrial homeostasis	179
SARS–CoV-2–specific T cell responses and correlations with COVID-19 patient predisposition	177
Selective glutamine metabolism inhibition in tumor cells improves antitumor T lymphocyte activity in triple-negative breast cancer	174
TYRO3 induces anti–PD-1/PD-L1 therapy resistance by limiting innate immunity and tumoral ferroptosis	168
Convalescent plasma anti–SARS-CoV-2 spike protein ectodomain and receptor-binding domain IgG correlate with virus neutralization	167
Long-term microstructure and cerebral blood flow changes in patients recovered from COVID-19 without neurological manifestations	161
Immune dysregulation as a driver of idiopathic pulmonary fibrosis	142
Peripheral CD4+ T cell subsets and antibody response in COVID-19 convalescent individuals	139
Endothelial C3a receptor mediates vascular inflammation and blood-brain barrier permeability during aging	134
Radiotherapy-exposed CD8+ and CD4+ neoantigens enhance tumor control	130
ATM inhibition enhances cancer immunotherapy by promoting mtDNA leakage and cGAS/STING activation	128
Bone marrow adipogenic lineage precursors promote osteoclastogenesis in bone remodeling and pathologic bone loss	126
Pharmacological treatment of hyperglycemia in type 2 diabetes	125
TREM2 sustains macrophage-hepatocyte metabolic coordination in nonalcoholic fatty liver disease and sepsis	125
Altered glycosylation of IgG4 promotes lectin complement pathway activation in anti-PLA2R1–associated membranous nephropathy	116
Biomarkers of inflammation and repair in kidney disease progression	113
Circulating markers of NADH-reductive stress correlate with mitochondrial disease severity	111
Antigen-driven clonal selection shapes the persistence of HIV-1–infected CD4+ T cells in vivo	111
Immune checkpoint inhibitor–associated myocarditis: manifestations and mechanisms	108
BCG vaccination history associates with decreased SARS-CoV-2 seroprevalence across a diverse cohort of health care workers	107
Dietary interventions for obesity: clinical and mechanistic findings	106

Impaired complex I repair causes recessive Leber’s hereditary optic neuropathy	105
Favorable outcomes of COVID-19 in recipients of hematopoietic cell transplantation	103
Lung megakaryocytes are immune modulatory cells	103
Sustained cellular immune dysregulation in individuals recovering from SARS-CoV-2 infection	103
Monogenic diabetes: a gateway to precision medicine in diabetes	101
Age-determined expression of priming protease TMPRSS2 and localization of SARS-CoV-2 in lung epithelium	100
Similarities and differences between the immunopathogenesis of COVID-19–related pediatric multisystem inflammatory syndrome and Kawasaki disease	99
Transcriptome-directed analysis for Mendelian disease diagnosis overcomes limitations of conventional genomic testing	99
Overcoming innate immune barriers that impede AAV gene therapy vectors	98
The lung microenvironment shapes a dysfunctional response of alveolar macrophages in aging	96
Corticosteroid treatment in severe COVID-19 patients with acute respiratory distress syndrome	92
Neutrophil-to-hepatocyte communication via LDLR-dependent miR-223–enriched extracellular vesicle transfer ameliorates nonalcoholic steatohepatitis	92
COVID-19 survival associates with the immunoglobulin response to the SARS-CoV-2 spike receptor binding domain	90
Hypoxia-inducible factor activity promotes antitumor effector function and tissue residency by CD8+ T cells	89
Functional monocytic myeloid-derived suppressor cells increase in blood but not airways and predict COVID-19 severity	89
Fecal microbiome and metabolome differ in healthy and food-allergic twins	85
Gastrointestinal motility disorders in neurologic disease	83
Mesenchymal Bmp3b expression maintains skeletal muscle integrity and decreases in age-related sarcopenia	82
The knowns and unknowns of latent Mycobacterium tuberculosis infection	79
SUMOylation promotes extracellular vesicle–mediated transmission of lncRNA ELNAT1 and lymph node metastasis in bladder cancer	76
Inhibition of 2-hydroxyglutarate elicits metabolic reprogramming and mutant IDH1 glioma immunity in mice	75
Healthy donor T cell responses to common cold coronaviruses and SARS-CoV-2	75
Herpes simplex encephalitis in a patient with a distinctive form of inherited IFNAR1 deficiency	74
Durable SARS-CoV-2 B cell immunity after mild or severe disease	74
IL-36 in chronic inflammation and fibrosis — bridging the gap?	74
Decreased adipose tissue oxygenation associates with insulin resistance in individuals with obesity	73
dmPFC-vlPAG projection neurons contribute to pain threshold maintenance and antianxiety behaviors	73
Type 1 diabetes mellitus: much progress, many opportunities	73
MAL2 drives immune evasion in breast cancer by suppressing tumor antigen presentation	72
Inflammatory syndromes associated with SARS-CoV-2 infection: dysregulation of the immune response across the age spectrum	71
Brain immune cells undergo cGAS/STING-dependent apoptosis during herpes simplex virus type 1 infection to limit type I IFN production	70
TLR3 controls constitutive IFN-β antiviral immunity in human fibroblasts and cortical neurons	69
Gluconeogenic enzyme PCK1 deficiency promotes CHK2 O-GlcNAcylation and hepatocellular carcinoma growth upon glucose deprivation	69
Clinical, laboratory, and temporal predictors of neutralizing antibodies against SARS-CoV-2 among COVID-19 convalescent plasma donor candidates	68
Bite of the wolf: innate immune responses propagate autoimmunity in lupus	68
Lipid-induced endothelial vascular cell adhesion molecule 1 promotes nonalcoholic steatohepatitis pathogenesis	67
Neutrophil dynamics in the tumor microenvironment	66
Tendon-derived cathepsin K–expressing progenitor cells activate Hedgehog signaling to drive heterotopic ossification	66
NLRP3 inflammasome induces CD4+ T cell loss in chronically HIV-1–infected patients	65
Age-related susceptibility to coronavirus infections: role of impaired and dysregulated host immunity	64
Ovariectomy induces bone loss via microbial-dependent trafficking of intestinal TNF+ T cells and Th17 cells	64
Pfs230 yields higher malaria transmission–blocking vaccine activity than Pfs25 in humans but not mice	63
Endoplasmic reticulum protein TXNDC5 promotes renal fibrosis by enforcing TGF-β signaling in kidney fibroblasts	62
Severe SARS-CoV-2 placenta infection can impact neonatal outcome in the absence of vertical transmission	62
PD-1 blockade improves Kupffer cell bacterial clearance in acute liver injury	62
Kisspeptin receptor agonist has therapeutic potential for female reproductive disorders	62
Oleic acid restores suppressive defects in tissue-resident FOXP3 Tregs from patients with multiple sclerosis	62
YIPF5 mutations cause neonatal diabetes and microcephaly through endoplasmic reticulum stress	62
Defective lysosome reformation during autophagy causes skeletal muscle disease	61
Interferons in cancer immunoediting: sculpting metastasis and immunotherapy response	60

Maintenance DNA methylation is essential for regulatory T cell development and stability of suppressive function	59
Insight into next-generation CAR therapeutics: designing CAR T cells to improve clinical outcomes	59
CCR5-edited CD4+ T cells augment HIV-specific immunity to enable post-rebound control of HIV replication	58
Antibody responses to endemic coronaviruses modulate COVID-19 convalescent plasma functionality	58
17β-estradiol and estrogen receptor α protect right ventricular function in pulmonary hypertension via BMPR2 and apelin	56
Macrophage AXL receptor tyrosine kinase inflames the heart after reperfused myocardial infarction	56
Cx43 hemichannel microdomain signaling at the intercalated disc enhances cardiac excitability	55
Congenital heart disease risk loci identified by genome-wide association study in European patients	55
BCL11A enhancer–edited hematopoietic stem cells persist in rhesus monkeys without toxicity	55
Inhibition of IRF5 hyperactivation protects from lupus onset and severity	53
Neutrophilic inflammation during lung development disrupts elastin assembly and predisposes adult mice to COPD	53
N-cadherin upregulation mediates adaptive radioresistance in glioblastoma	53
DYRK1A regulates B cell acute lymphoblastic leukemia through phosphorylation of FOXO1 and STAT3	52
Gs/Gq signaling switch in β cells defines incretin effectiveness in diabetes	52
Mitochondrial dysfunction in inflammatory bowel disease alters intestinal epithelial metabolism of hepatic acylcarnitines	51
Myeloid cell–targeted STAT3 inhibition sensitizes head and neck cancers to radiotherapy and T cell–mediated immunity	51
Epicutaneous Staphylococcus aureus induces IL-36 to enhance IgE production and ensuing allergic disease	51
Oxidized CaMKII and O-GlcNAcylation cause increased atrial fibrillation in diabetic mice by distinct mechanisms	51
Adenosine A3 agonists reverse neuropathic pain via T cell–mediated production of IL-10	51
SARS-CoV-2 variants and convalescent plasma: reality, fallacies, and opportunities	49
Nitric oxide modulates bone anabolism through regulation of osteoblast glycolysis and differentiation	49
Selective expansion of regulatory T cells using an orthogonal IL-2/IL-2 receptor system facilitates transplantation tolerance	48
Residual β cell function in long-term type 1 diabetes associates with reduced incidence of hypoglycemia	48
Macrophage SR-BI modulates autophagy via VPS34 complex and PPARα transcription of Tfeb in atherosclerosis	48
Corticosteroids, COVID-19 pneumonia, and acute respiratory distress syndrome	48
IRF3 reduces adipose thermogenesis via ISG15-mediated reprogramming of glycolysis	47
Catenin α 1 mutations cause familial exudative vitreoretinopathy by overactivating Norrin/β-catenin signaling	46
The discovery of insulin revisited: lessons for the modern era	46
Humanized neurofibroma model from induced pluripotent stem cells delineates tumor pathogenesis and developmental origins	45
TREM-1 orchestrates angiotensin II–induced monocyte trafficking and promotes experimental abdominal aortic aneurysm	45
Lysophospholipid acylation modulates plasma membrane lipid organization and insulin sensitivity in skeletal muscle	45
A GABAergic neural circuit in the ventromedial hypothalamus mediates chronic stress–induced bone loss	43
Turning lead into gold: reprogramming retinal cells to cure blindness	43
Severe insulin resistance syndromes	43
Normal and defective pathways in biogenesis and maintenance of the insulin storage pool	43
Bone marrow niche ATP levels determine leukemia-initiating cell activity via P2X7 in leukemic models	43
A replication-competent adenovirus-vectored influenza vaccine induces durable systemic and mucosal immunity	42
mTOR-dependent translation amplifies microglia priming in aging mice	42
RNF168 regulates R-loop resolution and genomic stability in BRCA1/2-deficient tumors	42
Carbohydrate restriction for diabetes: rediscovering centuries-old wisdom	41
COVID-19 vaccine testing in pregnant females is necessary	40
Zeb1 modulates hematopoietic stem cell fates required for suppressing acute myeloid leukemia	39
CLIC1 recruits PIP5K1A/C to induce cell-matrix adhesions for tumor metastasis	39
Inhibiting the MNK1/2-eIF4E axis impairs melanoma phenotype switching and potentiates antitumor immune responses	39
Atorvastatin is associated with reduced cisplatin-induced hearing loss	39
Galectin-7 downregulation in lesional keratinocytes contributes to enhanced IL-17A signaling and skin pathology in psoriasis	38
NOTCH-induced rerouting of endosomal trafficking disables regulatory T cells in vasculitis	38
The matrix metalloproteinase inhibitor IPR-179 has antiseizure and antiepileptogenic effects	38
Dynamic single-cell RNA sequencing identifies immunotherapy persister cells following PD-1 blockade	38
MAPK4 promotes prostate cancer by concerted activation of androgen receptor and AKT	38
Hypoxia-inducible factor–1α–dependent induction of miR122 enhances hepatic ischemia tolerance	37
Guanosine triphosphate links MYC-dependent metabolic and ribosome programs in small-cell lung cancer	37
Macrophage-mediated vascular permeability via VLA4/VCAM1 pathway dictates ascites development in ovarian cancer	37
Ventromedial hypothalamic primary cilia control energy and skeletal homeostasis	37
Lymphohematopoietic graft-versus-host responses promote mixed chimerism in patients receiving intestinal transplantation	37
Cholinergic dysfunction in the dorsal striatum promotes habit formation and maladaptive eating	36
CRISPR/Cas9 directed to the Ube3a antisense transcript improves Angelman syndrome phenotype in mice	36
Natural killer cells activated through NKG2D mediate lung ischemia-reperfusion injury	36
YAP plays a crucial role in the development of cardiomyopathy in lysosomal storage diseases	35
Endothelium-derived semaphorin 3G attenuates ischemic retinopathy by coordinating β-catenin–dependent vascular remodeling	35
CMV viral load kinetics as surrogate endpoints after allogeneic transplantation	35
ANGPTL2-containing small extracellular vesicles from vascular endothelial cells accelerate leukemia progression	35
Macrophage-derived netrin-1 drives adrenergic nerve–associated lung fibrosis	35
Turbinmicin inhibits Candida biofilm growth by disrupting fungal vesicle–mediated trafficking	35
Stressed erythrophagocytosis induces immunosuppression during sepsis through heme-mediated STAT1 dysregulation	34
Bardet-Biedl syndrome proteins regulate intracellular signaling and neuronal function in patient-specific iPSC-derived neurons	34
The COVID-19 immune landscape is dynamically and reversibly correlated with disease severity	34
Deficiency of macrophage PHACTR1 impairs efferocytosis and promotes atherosclerotic plaque necrosis	33
America’s deadly flirtation with antiscience and the medical freedom movement	33
Augmented antibody-based anticancer therapeutics boost neutrophil cytotoxicity	33
BCL6 confers KRAS-mutant non–small-cell lung cancer resistance to BET inhibitors	32
Extracellular traps released by antimicrobial TH17 cells contribute to host defense	32
Identification of human long noncoding RNAs associated with nonalcoholic fatty liver disease and metabolic homeostasis	32
Apobec1 complementation factor overexpression promotes hepatic steatosis, fibrosis, and hepatocellular cancer	31
Research gaps in medical treatment of transgender/nonbinary people	31
Targeting the histone demethylase LSD1 prevents cardiomyopathy in a mouse model of laminopathy	31
From the gut to bone: connecting the gut microbiota with Th17 T lymphocytes and postmenopausal osteoporosis	31
Hypothalamic REV-ERB nuclear receptors control diurnal food intake and leptin sensitivity in diet-induced obese mice	31
NOD2 drives early IL-33–dependent expansion of group 2 innate lymphoid cells during Crohn’s disease–like ileitis	31
Regulation and targeting of androgen receptor nuclear localization in castration-resistant prostate cancer	31

Human skin is colonized by T cells that recognize CD1a independently of lipid	31
Targeting a Braf/Mapk pathway rescues podocyte lipid peroxidation in CoQ-deficiency kidney disease	31
The integrated stress response mediates necrosis in murine Mycobacterium tuberculosis granulomas	31
BCG vaccination in health care providers and the protection against COVID-19	31