OOIR: Observatory of International Research

Papers

(The H4-Index of Journal of Clinical Investigation is 60. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-01-01 to 2025-01-01.)

Article	Citations
Gastrointestinal motility disorders in neurologic disease	267
The vascular landscape of human cancer	226
ABO blood type: a window into the genetics of acute respiratory distress syndrome susceptibility	214
Targeting the mutant p53 secretome	188
Changes in the National Cancer Institute’s R01 workforce: growth, aging, retention, and policy implications	188
Age-specific effects of vaccine egg adaptation and immune priming on A(H3N2) antibody responses following influenza vaccination	168
Herpes simplex encephalitis in a patient with a distinctive form of inherited IFNAR1 deficiency	166
NOD2 drives early IL-33–dependent expansion of group 2 innate lymphoid cells during Crohn’s disease–like ileitis	150
Epigenetic reprogramming to prevent genetic cardiomyopathy	142
Prolonged adaptive immune activation in COVID-19: implications for maintenance of long-term immunity?	140
An abundant biliary metabolite derived from dietary omega-3 polyunsaturated fatty acids regulates triglycerides	131
Propranolol inhibits cavernous vascular malformations by β1 adrenergic receptor antagonism in animal models	128
Paracardial fat and vitamin A: a mechanism for regulating exercise performance	126
Identification of SARS-CoV-2–specific immune alterations in acutely ill patients	125
Research gaps in medical treatment of transgender/nonbinary people	121
VCAM-1: closing the gap between lipotoxicity and endothelial dysfunction in nonalcoholic steatohepatitis	119
Plasma cells promote osteoclastogenesis and periarticular bone loss in autoimmune arthritis	118
Selective glutamine metabolism inhibition in tumor cells improves antitumor T lymphocyte activity in triple-negative breast cancer	113
Targeting the mitochondrial trifunctional protein restrains tumor growth in oxidative lung carcinomas	111
Interferons in cancer immunoediting: sculpting metastasis and immunotherapy response	108
Testosterone replacement in aging men: an evidence-based patient-centric perspective	107
Insight into next-generation CAR therapeutics: designing CAR T cells to improve clinical outcomes	107
A sobering addition to the literature on COVID-19 and the brain	103
Residual β cell function in long-term type 1 diabetes associates with reduced incidence of hypoglycemia	103
Immune MAL2-practice: breast cancer immunoevasion via MHC class I degradation	103

Remodeling glycerophospholipids affects obesity-related insulin signaling in skeletal muscle	101
CC17 group B Streptococcus exploits integrins for neonatal meningitis development	101
Combined immunodeficiency due to a mutation in the γ1 subunit of the coat protein I complex	100
Lysophospholipid acylation modulates plasma membrane lipid organization and insulin sensitivity in skeletal muscle	98
Targeting a Braf/Mapk pathway rescues podocyte lipid peroxidation in CoQ-deficiency kidney disease	96
Inhibiting the MNK1/2-eIF4E axis impairs melanoma phenotype switching and potentiates antitumor immune responses	95
TREM2 sustains macrophage-hepatocyte metabolic coordination in nonalcoholic fatty liver disease and sepsis	89
IRF3 reduces adipose thermogenesis via ISG15-mediated reprogramming of glycolysis	89
A replication-competent adenovirus-vectored influenza vaccine induces durable systemic and mucosal immunity	89
SUMOylation promotes extracellular vesicle–mediated transmission of lncRNA ELNAT1 and lymph node metastasis in bladder cancer	85
Lung megakaryocytes are immune modulatory cells	85
Renal tubule Cpt1a overexpression protects from kidney fibrosis by restoring mitochondrial homeostasis	83
Brain immune cells undergo cGAS/STING-dependent apoptosis during herpes simplex virus type 1 infection to limit type I IFN production	83
Neutrophil-to-hepatocyte communication via LDLR-dependent miR-223–enriched extracellular vesicle transfer ameliorates nonalcoholic steatohepatitis	80
Aberrant AZIN2 and polyamine metabolism precipitates tau neuropathology	76
Integrating imaging and RNA-seq improves outcome prediction in cervical cancer	75
Paracardial fat remodeling affects systemic metabolism through alcohol dehydrogenase 1	74
Endoplasmic reticulum stress sensor IRE1α propels neutrophil hyperactivity in lupus	74
The use of observational research to inform clinical practice	74
Bone marrow niche ATP levels determine leukemia-initiating cell activity via P2X7 in leukemic models	73
Muscle Krüppel-like factor 15 regulates lipid flux and systemic metabolic homeostasis	72
Uridine diphosphate–glucose/P2Y14R axis is a nonchemokine pathway that selectively promotes eosinophil accumulation	71
Chemical pancreatectomy treats chronic pancreatitis while preserving endocrine function in preclinical models	70
Lymphohematopoietic graft-versus-host responses promote mixed chimerism in patients receiving intestinal transplantation	69
Satellite glial GPR37L1 and its ligand maresin 1 regulate potassium channel signaling and pain homeostasis	68
Cyclin A2 maintains colon homeostasis and is a prognostic factor in colorectal cancer	67
America’s deadly flirtation with antiscience and the medical freedom movement	66
The power of two: lessons from a scientific partnership	65
A conversation with Robert Lefkowitz	65
The JCI Scholar experience strengthens physician-scientist training	64
Proteomic and metabolomic advances uncover biomarkers of mitochondrial disease pathophysiology and severity	63
Battle for supremacy: nucleic acid interactions between viruses and cells	62
Keeping the peace: commensal Cutibacterium acnes trains CD4+ TH17 cells to trap and kill	62
Long-term microstructure and cerebral blood flow changes in patients recovered from COVID-19 without neurological manifestations	62
Metabolic rerouting via SCD1 induction impacts X-linked adrenoleukodystrophy	61
Bite of the wolf: innate immune responses propagate autoimmunity in lupus	60