OOIR: Observatory of International Research

Papers

(The H4-Index of Journal of Clinical Investigation is 85. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-04-01 to 2024-04-01.)

Article	Citations
Clinical and immunological features of severe and moderate coronavirus disease 2019	3496
SARS-CoV-2: a storm is raging	869
Deployment of convalescent plasma for the prevention and treatment of COVID-19	581
Complement and tissue factor–enriched neutrophil extracellular traps are key drivers in COVID-19 immunothrombosis	551
Kinetics of viral load and antibody response in relation to COVID-19 severity	460
Impaired immune cell cytotoxicity in severe COVID-19 is IL-6 dependent	400
Immune responses to stroke: mechanisms, modulation, and therapeutic potential	344
SARS–CoV-2 infection of the placenta	338
Sex, age, and hospitalization drive antibody responses in a COVID-19 convalescent plasma donor population	334
Multisystem inflammatory syndrome in children and COVID-19 are distinct presentations of SARS–CoV-2	296
Early safety indicators of COVID-19 convalescent plasma in 5000 patients	293
Distinct clinical and immunological features of SARS–CoV-2–induced multisystem inflammatory syndrome in children	275
Recent endemic coronavirus infection is associated with less-severe COVID-19	254
Targeting glutamine metabolism enhances tumor-specific immunity by modulating suppressive myeloid cells	223
mRNA vaccine–induced neoantigen-specific T cell immunity in patients with gastrointestinal cancer	216
SARS-CoV-2–specific CD8+ T cell responses in convalescent COVID-19 individuals	199
Baricitinib restrains the immune dysregulation in patients with severe COVID-19	195
Targeting tumor-associated macrophages and granulocytic myeloid-derived suppressor cells augments PD-1 blockade in cholangiocarcinoma	181
Insulin signaling in health and disease	175
SARS–CoV-2–specific T cell responses and correlations with COVID-19 patient predisposition	172
HIFs, angiogenesis, and metabolism: elusive enemies in breast cancer	170
Convalescent plasma anti–SARS-CoV-2 spike protein ectodomain and receptor-binding domain IgG correlate with virus neutralization	162
Immune escape and immunotherapy of acute myeloid leukemia	157
COVID-19 severity associates with pulmonary redistribution of CD1c+ DCs and inflammatory transitional and nonclassical monocytes	156
Renal tubule Cpt1a overexpression protects from kidney fibrosis by restoring mitochondrial homeostasis	144

Selective glutamine metabolism inhibition in tumor cells improves antitumor T lymphocyte activity in triple-negative breast cancer	142
Long-term microstructure and cerebral blood flow changes in patients recovered from COVID-19 without neurological manifestations	137
Impact of TREM2R47H variant on tau pathology–induced gliosis and neurodegeneration	136
Contributions of alveolar epithelial cell quality control to pulmonary fibrosis	135
A tumor-intrinsic PD-L1/NLRP3 inflammasome signaling pathway drives resistance to anti–PD-1 immunotherapy	134
TYRO3 induces anti–PD-1/PD-L1 therapy resistance by limiting innate immunity and tumoral ferroptosis	132
Herpesvirus latency	127
Hypoxia-inducible factors and obstructive sleep apnea	127
Peripheral CD4+ T cell subsets and antibody response in COVID-19 convalescent individuals	123
Truncated stathmin-2 is a marker of TDP-43 pathology in frontotemporal dementia	119
Boosting NAD level suppresses inflammatory activation of PBMCs in heart failure	117
TRPV4 channel opening mediates pressure-induced pancreatitis initiated by Piezo1 activation	117
IL-17 and immunologically induced senescence regulate response to injury in osteoarthritis	117
Urine DNA methylation assay enables early detection and recurrence monitoring for bladder cancer	112
Endothelial C3a receptor mediates vascular inflammation and blood-brain barrier permeability during aging	111
IL-1β suppression of VE-cadherin transcription underlies sepsis-induced inflammatory lung injury	111
The COVID-19 pandemic and research shutdown: staying safe and productive	111
Immune dysregulation as a driver of idiopathic pulmonary fibrosis	109
Single residue in CD28-costimulated CAR-T cells limits long-term persistence and antitumor durability	109
p53/microRNA-214/ULK1 axis impairs renal tubular autophagy in diabetic kidney disease	109
Circular RNA-ZNF532 regulates diabetes-induced retinal pericyte degeneration and vascular dysfunction	108
Epigenetic driver mutations in ARID1A shape cancer immune phenotype and immunotherapy	108
Radiotherapy-exposed CD8+ and CD4+ neoantigens enhance tumor control	108
Bile acid metabolism is altered in multiple sclerosis and supplementation ameliorates neuroinflammation	107
IRF4 instructs effector Treg differentiation and immune suppression in human cancer	106
Cytotoxic CD4+ T lymphocytes may induce endothelial cell apoptosis in systemic sclerosis	105
Hypoxia-inducible factor signaling in pulmonary hypertension	103
TREM2 sustains macrophage-hepatocyte metabolic coordination in nonalcoholic fatty liver disease and sepsis	103
Pharmacological treatment of hyperglycemia in type 2 diabetes	102
Antigen-driven clonal selection shapes the persistence of HIV-1–infected CD4+ T cells in vivo	101
ATM inhibition enhances cancer immunotherapy by promoting mtDNA leakage and cGAS/STING activation	101
HDAC inhibitors elicit metabolic reprogramming by targeting super-enhancers in glioblastoma models	100
BCG vaccination history associates with decreased SARS-CoV-2 seroprevalence across a diverse cohort of health care workers	100
Sleeping Beauty–engineered CAR T cells achieve antileukemic activity without severe toxicities	98
Bone marrow adipogenic lineage precursors promote osteoclastogenesis in bone remodeling and pathologic bone loss	98
Microenvironmental Th9 and Th17 lymphocytes induce metastatic spreading in lung cancer	97
Favorable outcomes of COVID-19 in recipients of hematopoietic cell transplantation	97
Melatonin inhibits cytosolic mitochondrial DNA–induced neuroinflammatory signaling in accelerated aging and neurodegeneration	97
Age-determined expression of priming protease TMPRSS2 and localization of SARS-CoV-2 in lung epithelium	96
Preventing cytokine storm syndrome in COVID-19 using α-1 adrenergic receptor antagonists	96
Sustained cellular immune dysregulation in individuals recovering from SARS-CoV-2 infection	94
Osteocyte necrosis triggers osteoclast-mediated bone loss through macrophage-inducible C-type lectin	93
Circadian rhythm influences induction of trained immunity by BCG vaccination	93
Biomarkers of inflammation and repair in kidney disease progression	93
Altered glycosylation of IgG4 promotes lectin complement pathway activation in anti-PLA2R1–associated membranous nephropathy	92
BCG vaccination in humans inhibits systemic inflammation in a sex-dependent manner	92
Lung megakaryocytes are immune modulatory cells	92
Similarities and differences between the immunopathogenesis of COVID-19–related pediatric multisystem inflammatory syndrome and Kawasaki disease	92
Circulating markers of NADH-reductive stress correlate with mitochondrial disease severity	91
Minimal PD-1 expression in mouse and human NK cells under diverse conditions	90

COVID-19 threatens health systems in sub-Saharan Africa: the eye of the crocodile	88
COVID-19 survival associates with the immunoglobulin response to the SARS-CoV-2 spike receptor binding domain	88
PD-1 blockade inhibits osteoclast formation and murine bone cancer pain	88
Inherited human IFN-γ deficiency underlies mycobacterial disease	87
Inhibition of mitophagy drives macrophage activation and antibacterial defense during sepsis	86
HIV-1 viremia not suppressible by antiretroviral therapy can originate from large T cell clones producing infectious virus	85
Corticosteroid treatment in severe COVID-19 patients with acute respiratory distress syndrome	85
Hypoxia-inducible factors and innate immunity in liver cancer	85
Functional monocytic myeloid-derived suppressor cells increase in blood but not airways and predict COVID-19 severity	85
Upregulation of Rubicon promotes autosis during myocardial ischemia/reperfusion injury	85
Impaired complex I repair causes recessive Leber’s hereditary optic neuropathy	85