Journal of Cell Biology

Article	Citations
LNCcation: lncRNA localization and function	608
SuperPlots: Communicating reproducibility and variability in cell biology	404
Mitochondrial regulation of ferroptosis	190
Autophagosome biogenesis: From membrane growth to closure	182
Lysosome biogenesis: Regulation and functions	154
The cell biology of synapse formation	138
Mitophagy pathways in health and disease	119
Critical role of mitochondrial ubiquitination and the OPTN–ATG9A axis in mitophagy	110
SARM1 acts downstream of neuroinflammatory and necroptotic signaling to induce axon degeneration	100
Paradoxical roles of caspase-3 in regulating cell survival, proliferation, and tumorigenesis	100
Liquid–liquid phase separation in autophagy	98
TMEM41B and VMP1 are scramblases and regulate the distribution of cholesterol and phosphatidylserine	91
STING induces LC3B lipidation onto single-membrane vesicles via the V-ATPase and ATG16L1-WD40 domain	88
VPS13D bridges the ER to mitochondria and peroxisomes via Miro	86
The RNA binding protein FMR1 controls selective exosomal miRNA cargo loading during inflammation	85
FUS-dependent liquid–liquid phase separation is important for DNA repair initiation	84
Lipid droplets in the nervous system	82
Mechanisms of nonvesicular lipid transport	82
Cancer cells educate natural killer cells to a metastasis-promoting cell state	82
The NLRP3–inflammasome as a sensor of organelle dysfunction	81
The cell biology of Parkinson’s disease	77
Recognition of RNA by the S9.6 antibody creates pervasive artifacts when imaging RNA:DNA hybrids	70
Mitochondria as intracellular signaling platforms in health and disease	70
CDK4/6 regulate lysosome biogenesis through TFEB/TFE3	69
Seipin and Nem1 establish discrete ER subdomains to initiate yeast lipid droplet biogenesis	68

Microtubules control cellular shape and coherence in amoeboid migrating cells	67
Sequential dynein effectors regulate axonal autophagosome motility in a maturation-dependent pathway	67
Who’s in control? Principles of Rab GTPase activation in endolysosomal membrane trafficking and beyond	67
3D FIB-SEM reconstruction of microtubule–organelle interaction in whole primary mouse β cells	62
PD-1 and BTLA regulate T cell signaling differentially and only partially through SHP1 and SHP2	61
Phospholipid ebb and flow makes mitochondria go	61
COPII collar defines the boundary between ER and ER exit site and does not coat cargo containers	60
The proline-rich domain promotes Tau liquid–liquid phase separation in cells	59
Pathogenic mutations in the kinesin-3 motor KIF1A diminish force generation and movement through allosteric mechanisms	59
Endosomal escape of delivered mRNA from endosomal recycling tubules visualized at the nanoscale	58
Phase separation of Axin organizes the β-catenin destruction complex	58
Ribosome heterogeneity in stem cells and development	57
Similarities and interplay between senescent cells and macrophages	57
ULK complex organization in autophagy by a C-shaped FIP200 N-terminal domain dimer	57
A PI3K-WIPI2 positive feedback loop allosterically activates LC3 lipidation in autophagy	56
Evolving models for assembling and shaping clathrin-coated pits	56
High-fidelity reconstitution of stress granules and nucleoli in mammalian cellular lysate	55
ECM deposition is driven by caveolin-1–dependent regulation of exosomal biogenesis and cargo sorting	53
V-ATPase is a universal regulator of LC3-associated phagocytosis and non-canonical autophagy	52
Ubiquitin chains earmark GPCRs for BBSome-mediated removal from cilia	52
High-content imaging-based pooled CRISPR screens in mammalian cells	51
The long journey to bring a Myc inhibitor to the clinic	50
Secretory autophagy maintains proteostasis upon lysosome inhibition	50
Topological features of integrin adhesion complexes revealed by multiplexed proximity biotinylation	50
Ubiquitin links smoothened to intraflagellar transport to regulate Hedgehog signaling	50
Time-resolved proteomics profiling of the ciliary Hedgehog response	49
VPS13D promotes peroxisome biogenesis	48
Nuclear lipid droplets form in the inner nuclear membrane in a seipin-independent manner	48
Role of the early secretory pathway in SARS-CoV-2 infection	48
Regulated lipid synthesis and LEM2/CHMP7 jointly control nuclear envelope closure	46
Image-based pooled whole-genome CRISPRi screening for subcellular phenotypes	46
TORC1 inactivation stimulates autophagy of nucleoporin and nuclear pore complexes	46
PINK1 drives production of mtDNA-containing extracellular vesicles to promote invasiveness	46
Torsin ATPase deficiency leads to defects in nuclear pore biogenesis and sequestration of MLF2	46
Stress sensor Ire1 deploys a divergent transcriptional program in response to lipid bilayer stress	45
Transmembrane phospholipid translocation mediated by Atg9 is involved in autophagosome formation	44
Adherens junction regulates cryptic lamellipodia formation for epithelial cell migration	43
Polo-like kinase 1 independently controls microtubule-nucleating capacity and size of the centrosome	43
Cytoskeletal organization of axons in vertebrates and invertebrates	42
Protrudin-mediated ER–endosome contact sites promote MT1-MMP exocytosis and cell invasion	42
CRISPR-Cas12a–assisted PCR tagging of mammalian genes	41
Sarm1 activation produces cADPR to increase intra-axonal Ca++ and promote axon degeneration in PIPN	41
Mitochondrial fragmentation enables localized signaling required for cell repair	40
Chlamydomonas PKD2 organizes mastigonemes, hair-like glycoprotein polymers on cilia	40
Interferon-stimulated gene 15 accelerates replication fork progression inducing chromosomal breakage	40
mTORC1 activity is supported by spatial association with focal adhesions	39
Catalytically inactive, purified RNase H1: A specific and sensitive probe for RNA–DNA hybrid imaging	39
Coupling of translation quality control and mRNA targeting to stress granules	39
CDC42EP5/BORG3 modulates SEPT9 to promote actomyosin function, migration, and invasion	38
Phagosome resolution regenerates lysosomes and maintains the degradative capacity in phagocytes	38

Synaptic activity controls autophagic vacuole motility and function in dendrites	38
Binding and transport of SFPQ-RNA granules by KIF5A/KLC1 motors promotes axon survival	38
Computational analyses reveal spatial relationships between nuclear pore complexes and specific lamins	37
Caveolin-1 and cavin1 act synergistically to generate a unique lipid environment in caveolae	37
Direct binding of ESCRT protein Chm7 to phosphatidic acid–rich membranes at nuclear envelope herniations	37
FIT2 is an acyl–coenzyme A diphosphatase crucial for endoplasmic reticulum homeostasis	37
DOT1L modulates the senescence-associated secretory phenotype through epigenetic regulation of IL1A	36
Rapid degradation of GRASP55 and GRASP65 reveals their immediate impact on the Golgi structure	36
Structural and biochemical insights into lipid transport by VPS13 proteins	36
Mechanosensitive calcium flashes promote sustained RhoA activation during tight junction remodeling	36
Analysis of copy number alterations reveals the lncRNA ALAL-1 as a regulator of lung cancer immune evasion	35
Regulation of Golgi turnover by CALCOCO1-mediated selective autophagy	35
SAMM50 acts with p62 in piecemeal basal- and OXPHOS-induced mitophagy of SAM and MICOS components	35
High-speed single-molecule imaging reveals signal transduction by induced transbilayer raft phases	35
Cyclin B1-Cdk1 facilitates MAD1 release from the nuclear pore to ensure a robust spindle checkpoint	34
ER-lysosome lipid transfer protein VPS13C/PARK23 prevents aberrant mtDNA-dependent STING signaling	34
The WAVE complex associates with sites of saddle membrane curvature	34
MICAL2 enhances branched actin network disassembly by oxidizing Arp3B-containing Arp2/3 complexes	33
Quantitative correlative microscopy reveals the ultrastructural distribution of endogenous endosomal proteins	33
The modified mitochondrial outer membrane carrier MTCH2 links mitochondrial fusion to lipogenesis	33
Tyramide signal amplification mass spectrometry (TSA-MS) ratio identifies nuclear speckle proteins	33
Telomerase treatment prevents lung profibrotic pathologies associated with physiological aging	33
PI4P/PS countertransport by ORP10 at ER–endosome membrane contact sites regulates endosome fission	33
HDAC6 regulates microtubule stability and clustering of AChRs at neuromuscular junctions	33
A cryo-ET survey of microtubules and intracellular compartments in mammalian axons	32
XMAP215 promotes microtubule catastrophe by disrupting the growing microtubule end	32
FHL2 anchors mitochondria to actin and adapts mitochondrial dynamics to glucose supply	32
Nesprins are mechanotransducers that discriminate epithelial–mesenchymal transition programs	32
Mitochondrial translation and dynamics synergistically extend lifespan in C. elegans through HLH-30	32
Ubiquitin ligase MARCH5 localizes to peroxisomes to regulate pexophagy	32
A non-canonical Hedgehog pathway initiates ciliogenesis and autophagy	32
Sterol biosensor reveals LAM-family Ltc1-dependent sterol flow to endosomes upon Arp2/3 inhibition	31
Alternative splicing of clathrin heavy chain contributes to the switch from coated pits to plaques	31
Long-lived mitochondrial cristae proteins in mouse heart and brain	31
PLCγ1 promotes phase separation of T cell signaling components	31
The cell biology of inflammation: From common traits to remarkable immunological adaptations	31
Lipid droplets and the host–pathogen dynamic: FATal attraction?	31
Intracellular wetting mediates contacts between liquid compartments and membrane-bound organelles	31
Prolonged mitosis results in structurally aberrant and over-elongated centrioles	30
The Rab7 effector WDR91 promotes autophagy-lysosome degradation in neurons by regulating lysosome fusion	30
Phosphorylation of SNX27 by MAPK11/14 links cellular stress–signaling pathways with endocytic recycling	30
Capture and delivery of tail-anchored proteins to the endoplasmic reticulum	30
ER as master regulator of membrane trafficking and organelle function	30
High-precision targeting workflow for volume electron microscopy	30
In situ cryo-electron tomography reveals filamentous actin within the microtubule lumen	30
ER–mitochondria contacts promote mitochondrial-derived compartment biogenesis	30
Label-retention expansion microscopy	29
USP19 promotes hypoxia-induced mitochondrial division via FUNDC1 at ER-mitochondria contact sites	29
Factors promoting nuclear envelope assembly independent of the canonical ESCRT pathway	29
Parkin-independent mitophagy via Drp1-mediated outer membrane severing and inner membrane ubiquitination	29
FMNL2 regulates dynamics of fascin in filopodia	29
GTP-dependent formation of straight tubulin oligomers leads to microtubule nucleation	29
CRISPR screens for lipid regulators reveal a role for ER-bound SNX13 in lysosomal cholesterol export	29
Mitochondrial DNA segregation and replication restrict the transmission of detrimental mutation	29
A guide to membrane atg8ylation and autophagy with reflections on immunity	29
Fission yeast Pak1 phosphorylates anillin-like Mid1 for spatial control of cytokinesis	29
Cargo crowding contributes to sorting stringency in COPII vesicles	29
Cnm1 mediates nucleus–mitochondria contact site formation in response to phospholipid levels	28
A polybasic domain in aPKC mediates Par6-dependent control of membrane targeting and kinase activity	28
Vps13-like proteins provide phosphatidylethanolamine for GPI anchor synthesis in the ER	28
ANO5 ensures trafficking of annexins in wounded myofibers	28
Centriole-independent mitotic spindle assembly relies on the PCNT–CDK5RAP2 pericentriolar matrix	28
Kinetochore phosphatases suppress autonomous Polo-like kinase 1 activity to control the mitotic checkpoint	28
Optogenetic activators of apoptosis, necroptosis, and pyroptosis	28
GOLPH3 and GOLPH3L are broad-spectrum COPI adaptors for sorting into intra-Golgi transport vesicles	28
Branched actin networks are assembled on microtubules by adenomatous polyposis coli for targeted membrane protrusion	28
WASP integrates substrate topology and cell polarity to guide neutrophil migration	27
Angulin-1 seals tricellular contacts independently of tricellulin and claudins	27
mRNA localization mediates maturation of cytoplasmic cilia in Drosophila spermatogenesis	27
Vps13D functions in a Pink1-dependent and Parkin-independent mitophagy pathway	27
Evidence for anaphase pulling forces during C. elegans meiosis	27
Induction of spontaneous human neocentromere formation and long-term maturation	27
CENP-A overexpression promotes aneuploidy with karyotypic heterogeneity	27
A modified lysosomal organelle mediates nonlytic egress of reovirus	26
Atlastin 2/3 regulate ER targeting of the ULK1 complex to initiate autophagy	26
Deorphanizing FAM19A proteins as pan-neurexin ligands with an unusual biosynthetic binding mechanism	26
Kinetochore-bound Mps1 regulates kinetochore–microtubule attachments via Ndc80 phosphorylation	26
NUCKS1 promotes RAD54 activity in homologous recombination DNA repair	26
An antibody toolbox to track complex I assembly defines AIF’s mitochondrial function	26
Plectin-mediated cytoskeletal crosstalk controls cell tension and cohesion in epithelial sheets	26

A ciliopathy complex builds distal appendages to initiate ciliogenesis	26
The UPRmt preserves mitochondrial import to extend lifespan	26
RIM-binding protein couples synaptic vesicle recruitment to release sites	25
A septin GTPase scaffold of dynein–dynactin motors triggers retrograde lysosome transport	25
C-ferroptosis is an iron-dependent form of regulated cell death in cyanobacteria	25
ORP5 and ORP8 orchestrate lipid droplet biogenesis and maintenance at ER–mitochondria contact sites	25
MICOS subcomplexes assemble independently on the mitochondrial inner membrane in proximity to ER contact sites	25
NCOA4 drives ferritin phase separation to facilitate macroferritinophagy and microferritinophagy	25
Atg39 links and deforms the outer and inner nuclear membranes in selective autophagy of the nucleus	25
Subcellular localization of the J-protein Sis1 regulates the heat shock response	25
CDKD-dependent activation of CDKA;1 controls microtubule dynamics and cytokinesis during meiosis	25
Conserved actin machinery drives microtubule-independent motility and phagocytosis in Naegleria	25
Consensus nomenclature for dyneins and associated assembly factors	25
NBR1: The archetypal selective autophagy receptor	25
Dendritic cell actin dynamics control contact duration and priming efficiency at the immunological synapse	25
Opposing functions for retromer and Rab11 in extracellular vesicle traffic at presynaptic terminals	25
p53 deficiency triggers dysregulation of diverse cellular processes in physiological oxygen	25
Structural insights into G domain dimerization and pathogenic mutation of OPA1	25
VMP1 and TMEM41B are essential for DMV formation during β-coronavirus infection	24
Notch2 complements Notch1 to mediate inductive signaling that initiates early T cell development	24
Cell division requires RNA eviction from condensing chromosomes	24
LUZP1 and the tumor suppressor EPLIN modulate actin stability to restrict primary cilia formation	24
The +TIP Navigator-1 is an actin–microtubule crosslinker that regulates axonal growth cone motility	24
TDP-43 mediates SREBF2-regulated gene expression required for oligodendrocyte myelination	24
Regulating peroxisome–ER contacts via the ACBD5-VAPB tether by FFAT motif phosphorylation and GSK3β	24
A mitochondrial contribution to anti-inflammatory shear stress signaling in vascular endothelial cells	24
Specific KIF1A–adaptor interactions control selective cargo recognition	24
Nano-scale resolution of native retinal rod disk membranes reveals differences in lipid composition	24
Effector-mediated ERM activation locally inhibits RhoA activity to shape the apical cell domain	23
Twinfilin bypasses assembly conditions and actin filament aging to drive barbed end depolymerization	23
Biochemical reconstitutions reveal principles of human γ-TuRC assembly and function	23
Molecular basis of MKLP2-dependent Aurora B transport from chromatin to the anaphase central spindle	23
Shared and specific functions of Arfs 1–5 at the Golgi revealed by systematic knockouts	23
Dual spindles assemble in bovine zygotes despite the presence of paternal centrosomes	23
Object detection networks and augmented reality for cellular detection in fluorescence microscopy	23
Stable inheritance of CENP-A chromatin: Inner strength versus dynamic control	23
The ER cholesterol sensor SCAP promotes CARTS biogenesis at ER–Golgi membrane contact sites	23
ATG9 vesicles comprise the seed membrane of mammalian autophagosomes	22
Cell migration orchestrates migrasome formation by shaping retraction fibers	22
An asymmetric junctional mechanoresponse coordinates mitotic rounding with epithelial integrity	22
Teasing out function from morphology: Similarities between primary cilia and immune synapses	22
An APEX2 proximity ligation method for mapping interactions with the nuclear lamina	22
ZNF416 is a pivotal transcriptional regulator of fibroblast mechanoactivation	22
Stochastic combinations of actin regulatory proteins are sufficient to drive filopodia formation	22
Collective invasion induced by an autocrine purinergic loop through connexin-43 hemichannels	22
FIT2 organizes lipid droplet biogenesis with ER tubule-forming proteins and septins	22
Live imaging of transcription sites using an elongating RNA polymerase II–specific probe	22
E3 ubiquitin ligase Wwp1 regulates ciliary dynamics of the Hedgehog receptor Smoothened	22
Nucleobindin-1 regulates ECM degradation by promoting intra-Golgi trafficking of MMPs	22
Retinyl esters form lipid droplets independently of triacylglycerol and seipin	22
Quality control of 40S ribosome head assembly ensures scanning competence	22
Liquid–liquid phase separation facilitates the biogenesis of secretory storage granules	22
Tension promotes kinetochore–microtubule release by Aurora B kinase	21
c entrocortin RNA localization to centrosomes is regulated by FMRP and facilitates error-free mitosis	21
ER membrane contact sites support endosomal small GTPase conversion for exosome secretion	21
SARS-CoV-2 ORF10 impairs cilia by enhancing CUL2ZYG11B activity	21
Phase separation and toxicity of C9orf72 poly(PR) depends on alternate distribution of arginine	21
Autophagy facilitates mitochondrial rebuilding after acute heat stress via a DRP-1–dependent process	21
Regulation of membrane NMDA receptors by dynamics and protein interactions	21
Confounding factors from inducible systems for spatiotemporal gene expression regulation	21
A loop extrusion–independent mechanism contributes to condensin I–mediated chromosome shaping	21
Intersection of TKS5 and FGD1/CDC42 signaling cascades directs the formation of invadopodia	21
STING controls energy stress-induced autophagy and energy metabolism via STX17	21
Centriole and PCM cooperatively recruit CEP192 to spindle poles to promote bipolar spindle assembly	20
Sterol and oxysterol synthases near the ciliary base activate the Hedgehog pathway	20
Extracellular vesicles from neurons promote neural induction of stem cells through cyclin D1	20
The deubiquitylase USP9X controls ribosomal stalling	20
Mechanical competition alters the cellular interpretation of an endogenous genetic program	20
ESCRT, not intralumenal fragments, sorts ubiquitinated vacuole membrane proteins for degradation	20
Tricellulin secures the epithelial barrier at tricellular junctions by interacting with actomyosin	20
WDR60-mediated dynein-2 loading into cilia powers retrograde IFT and transition zone crossing	20
Individual kinetochore-fibers locally dissipate force to maintain robust mammalian spindle structure	20
Plk4 triggers autonomous de novo centriole biogenesis and maturation	20
Combinatorial multivalent interactions drive cooperative assembly of the COPII coat	20
O-GlcNAc modification of nuclear pore complexes accelerates bidirectional transport	20
Myelination generates aberrant ultrastructure that is resolved by microglia	20
The cell biology of fertilization: Gamete attachment and fusion	20
Zc3h10 regulates adipogenesis by controlling translation and F-actin/mitochondria interaction	20
Protein exchange is reduced in calcium-independent epithelial junctions	20
Superresolution characterization of core centriole architecture	20
Quantitative analysis of autophagy reveals the role of ATG9 and ATG2 in autophagosome formation	20
The function of GORASPs in Golgi apparatus organization in vivo	20
Genetically encoded live-cell sensor for tyrosinated microtubules	20
MyD88 oligomer size functions as a physical threshold to trigger IL1R Myddosome signaling	20
Aurora A kinase activation: Different means to different ends	19
Lymphocyte egress signal sphingosine-1-phosphate promotes ERM-guided, bleb-based migration	19
Centromeric transcription maintains centromeric cohesion in human cells	19
Novel phospho-switch function of delta-catenin in dendrite development	19
Mitochondria on the move: Horizontal mitochondrial transfer in disease and health	19
JIP3 interacts with dynein and kinesin-1 to regulate bidirectional organelle transport	19
KIF14 controls ciliogenesis via regulation of Aurora A and is important for Hedgehog signaling	19
Mechanosensitive collaboration between integrins and connexins allows nutrient and antioxidant transport into the lens	19
Multivalent interactions make adherens junction–cytoskeletal linkage robust during morphogenesis	19
Stress granules and mTOR are regulated by membrane atg8ylation during lysosomal damage	19
Stress-responsive regulation of extracellular proteostasis	19