Journal of Biological Chemistry

Article	Citations
The molecular virology of coronaviruses	378
Mechanisms of evolved herbicide resistance	351
SARS-CoV-2 infects cells after viral entry via clathrin-mediated endocytosis	323
Inhibition of SARS–CoV-2 by type I and type III interferons	213
Molnupiravir promotes SARS-CoV-2 mutagenesis via the RNA template	212
The SARS-CoV-2 envelope and membrane proteins modulate maturation and retention of the spike protein, allowing assembly of virus-like particles	209
Oxygen battle in the gut: Hypoxia and hypoxia-inducible factors in metabolic and inflammatory responses in the intestine	197
Antisense technology: A review	175
The essential elements of Alzheimer’s disease	154
Structural and functional conservation of the programmed −1 ribosomal frameshift signal of SARS coronavirus 2 (SARS-CoV-2)	152
Impaired NLRP3 inflammasome activation/pyroptosis leads to robust inflammatory cell death via caspase-8/RIPK3 during coronavirus infection	146
Zinc transporters and their functional integration in mammalian cells	137
Recent advances in de novo protein design: Principles, methods, and applications	130
Major advances in targeted protein degradation: PROTACs, LYTACs, and MADTACs	129
Post-translational modifications of Hsp90 and translating the chaperone code	126
The interplay of fibroblasts, the extracellular matrix, and inflammation in scar formation	126
Coronavirus infection and PARP expression dysregulate the NAD metabolome: An actionable component of innate immunity	122
Template-dependent inhibition of coronavirus RNA-dependent RNA polymerase by remdesivir reveals a second mechanism of action	120
Mitochondrial metabolism regulates macrophage biology	117
Post-translational modifications of Hsp70 family proteins: Expanding the chaperone code	111
The emerging role of α-synuclein truncation in aggregation and disease	109
Mechanisms of adhesion G protein–coupled receptor activation	108
Lipopolysaccharide O-antigens—bacterial glycans made to measure	104
Disassembly of Tau fibrils by the human Hsp70 disaggregation machinery generates small seeding-competent species	100
Piezo1 acts upstream of TRPV4 to induce pathological changes in endothelial cells due to shear stress	100

ZBP1 promotes fungi-induced inflammasome activation and pyroptosis, apoptosis, and necroptosis (PANoptosis)	99
The chaperone GRP78 is a host auxiliary factor for SARS-CoV-2 and GRP78 depleting antibody blocks viral entry and infection	99
Role of the lipid bilayer in outer membrane protein folding in Gram-negative bacteria	97
The 89-kDa PARP1 cleavage fragment serves as a cytoplasmic PAR carrier to induce AIF-mediated apoptosis	97
Unusual zwitterionic catalytic site of SARS–CoV-2 main protease revealed by neutron crystallography	97
Structural basis for the in vitro efficacy of nirmatrelvir against SARS-CoV-2 variants	94
1,6-Hexanediol, commonly used to dissolve liquid–liquid phase separated condensates, directly impairs kinase and phosphatase activities	93
N6-Methyladenosine modification of hepatitis B and C viral RNAs attenuates host innate immunity via RIG-I signaling	91
The importance of thiamine (vitamin B1) in plant health: From crop yield to biofortification	90
A molecular roadmap to the plant immune system	89
Discovery of amivantamab (JNJ-61186372), a bispecific antibody targeting EGFR and MET	88
The SARS-CoV-2 Y453F mink variant displays a pronounced increase in ACE-2 affinity but does not challenge antibody neutralization	87
Deubiquitinating enzymes (DUBs): Regulation, homeostasis, and oxidative stress response	87
The spike protein of SARS-CoV-2 induces endothelial inflammation through integrin α5β1 and NF-κB signaling	82
SARS-CoV-2 viral budding and entry can be modeled using BSL-2 level virus-like particles	81
Toward the solution of the protein structure prediction problem	79
Seeing beyond the limit: A guide to choosing the right super-resolution microscopy technique	79
High affinity binding of SARS-CoV-2 spike protein enhances ACE2 carboxypeptidase activity	78
Regulation and function of the mammalian tricarboxylic acid cycle	76
From OCR and ECAR to energy: Perspectives on the design and interpretation of bioenergetics studies	76
Small molecule strategies to harness the unfolded protein response: where do we go from here?	75
Role of host factors in SARS-CoV-2 entry	73
Acidity and nucleophilic reactivity of glutathione persulfide	73
Exploring cellular biochemistry with nanobodies	72
Exosome-mediated mRNA delivery in vivo is safe and can be used to induce SARS-CoV-2 immunity	71
Bacterial iron detoxification at the molecular level	70
Presence of hyaluronan in lung alveoli in severe Covid-19: An opening for new treatment options?	68
Targeting mitophagy in Parkinson's disease	67
Inhibition of acid sphingomyelinase by ambroxol prevents SARS-CoV-2 entry into epithelial cells	66
Iron homeostasis and plant immune responses: Recent insights and translational implications	66
Adipose mesenchymal stem cell-derived extracellular vesicles containing microRNA-26a-5p target TLR4 and protect against diabetic nephropathy	65
The SARS-CoV-2 Nsp3 macrodomain reverses PARP9/DTX3L-dependent ADP-ribosylation induced by interferon signaling	65
Structure and function of the ecto-nucleotide pyrophosphatase/phosphodiesterase (ENPP) family: Tidying up diversity	64
Molecular mechanisms of telomere biology disorders	64
Structural analysis of carbohydrate binding by the macrophage mannose receptor CD206	62
Priming of SARS-CoV-2 S protein by several membrane-bound serine proteinases could explain enhanced viral infectivity and systemic COVID-19 infection	62
Sodium-glucose cotransporter-2 inhibitors: Understanding the mechanisms for therapeutic promise and persisting risks	60
Super-rapid quantitation of the production of HIV-1 harboring a luminescent peptide tag	60
Multiple variants of the fungal effector AVR-Pik bind the HMA domain of the rice protein OsHIPP19, providing a foundation to engineer plant defense	60
Truncation of Tau selectively facilitates its pathological activities	60
Bilirubin remodels murine white adipose tissue by reshaping mitochondrial activity and the coregulator profile of peroxisome proliferator–activated receptor α	59
There’s more to death than life: Noncatalytic functions in kinase and pseudokinase signaling	59
Adaptation of influenza viruses to human airway receptors	58
Regulation of tau internalization, degradation, and seeding by LRP1 reveals multiple pathways for tau catabolism	58
From structure to the dynamic regulation of a molecular switch: A journey over 3 decades	58
Flagging fusion: Phosphatidylserine signaling in cell–cell fusion	58
Update and nomenclature proposal for mammalian lysophospholipid acyltransferases, which create membrane phospholipid diversity	57
The m6A methyltransferase METTL3 modifies PGC-1α mRNA promoting mitochondrial dysfunction and oxLDL-induced inflammation in monocytes	57
Viperin: An ancient radical SAM enzyme finds its place in modern cellular metabolism and innate immunity	57
Structural insights into emergent signaling modes of G protein–coupled receptors	57

Phase separation by the SARS-CoV-2 nucleocapsid protein: Consensus and open questions	56
The binding of heparin to spike glycoprotein inhibits SARS-CoV-2 infection by three mechanisms	56
Genetic glycoengineering in mammalian cells	56
Chemistry of Class 1 CRISPR-Cas effectors: Binding, editing, and regulation	55
Ferroptosis drives photoreceptor degeneration in mice with defects in all-trans-retinal clearance	55
From overnutrition to liver injury: AMP-activated protein kinase in nonalcoholic fatty liver diseases	54
Survivin in breast cancer–derived exosomes activates fibroblasts by up-regulating SOD1, whose feedback promotes cancer proliferation and metastasis	53
From integrative structural biology to cell biology	53
Redesigning plant cell walls for the biomass-based bioeconomy	53
ATP13A3 is a major component of the enigmatic mammalian polyamine transport system	52
African swine fever virus protein MGF-505-7R promotes virulence and pathogenesis by inhibiting JAK1- and JAK2-mediated signaling	52
Sialic acid O-acetylation: From biosynthesis to roles in health and disease	52
Genetic and biased agonist-mediated reductions in β-arrestin recruitment prolong cAMP signaling at glucagon family receptors	50
The transcription factor BACH1 at the crossroads of cancer biology: From epithelial–mesenchymal transition to ferroptosis	49
Arginine methylation of SARS-Cov-2 nucleocapsid protein regulates RNA binding, its ability to suppress stress granule formation, and viral replication	49
A shared, stochastic pathway mediates exosome protein budding along plasma and endosome membranes	48
Metabolic regulation of ferroptosis in the tumor microenvironment	48
Gallic acid is a dual α/β-secretase modulator that reverses cognitive impairment and remediates pathology in Alzheimer mice	48
Two distinct trophectoderm lineage stem cells from human pluripotent stem cells	48
Structure, mechanism, and regulation of mitochondrial DNA transcription initiation	48
How repertoire data are changing antibody science	47
H2S and reactive sulfur signaling at the host-bacterial pathogen interface	47
In vivo two-photon microscopy reveals the contribution of Sox9+ cell to kidney regeneration in a mouse model with extracellular vesicle treatment	47
Engineering acyl-homoserine lactone-interfering enzymes toward bacterial control	47
The detection and functions of RNA modification m6A based on m6A writers and erasers	47
Folding or holding?—Hsp70 and Hsp90 chaperoning of misfolded proteins in neurodegenerative disease	47
D614G mutation in the SARS-CoV-2 spike protein enhances viral fitness by desensitizing it to temperature-dependent denaturation	47
TET-mediated 5-methylcytosine oxidation in tRNA promotes translation	46
Metabolite sensing and signaling in cancer	45
Effective delivery of STING agonist using exosomes suppresses tumor growth and enhances antitumor immunity	45
The role of PLCγ2 in immunological disorders, cancer, and neurodegeneration	45
Emerging roles of the MAGE protein family in stress response pathways	45
Identification of an anti–SARS–CoV-2 receptor-binding domain–directed human monoclonal antibody from a naïve semisynthetic library	45
Biological and catalytic functions of sirtuin 6 as targets for small-molecule modulators	45
Crystal structure of a human plasma membrane phospholipid flippase	45
Myricetin slows liquid–liquid phase separation of Tau and activates ATG5-dependent autophagy to suppress Tau toxicity	44
Mechanisms tailoring the expression of heat shock proteins to proteostasis challenges	44
PDLIM5 inhibits STUB1-mediated degradation of SMAD3 and promotes the migration and invasion of lung cancer cells	44
Cardiac myosin contraction and mechanotransduction in health and disease	44
Interplay between primary familial brain calcification-associated SLC20A2 and XPR1 phosphate transporters requires inositol polyphosphates for control of cellular phosphate homeostasis	44
Phase separation drives decision making in cell division	44
Famotidine inhibits toll-like receptor 3-mediated inflammatory signaling in SARS-CoV-2 infection	43
Findings in redox biology: From H2O2 to oxidative stress	43
Runt-related transcription factor 1 is required for murine osteoblast differentiation and bone formation	43
Major tail proteins of bacteriophages of the order Caudovirales	43
A RIG-I–like receptor directs antiviral responses to a bunyavirus and is antagonized by virus-induced blockade of TRIM25-mediated ubiquitination	43
Flavonols modulate lateral root emergence by scavenging reactive oxygen species in Arabidopsis thaliana	43
Highlighting membrane protein structure and function: A celebration of the Protein Data Bank	43
The scrambled story between hyaluronan and glioblastoma	43
Canonical Notch ligands and Fringes have distinct effects on NOTCH1 and NOTCH2	42
Structural and molecular basis for the substrate positioning mechanism of a new PL7 subfamily alginate lyase from the arctic	42
Impact of temperature on the affinity of SARS-CoV-2 Spike glycoprotein for host ACE2	42
Manganese promotes α-synuclein amyloid aggregation through the induction of protein phase transition	42
Structural basis of nirmatrelvir and ensitrelvir activity against naturally occurring polymorphisms of the SARS-CoV-2 main protease	42
HIV-cell membrane fusion intermediates are restricted by Serincs as revealed by cryo-electron and TIRF microscopy	42
Strategies for site-specific recombination with high efficiency and precise spatiotemporal resolution	42
Translational regulation of environmental adaptation in bacteria	41
Ferric uptake regulator (Fur) reversibly binds a [2Fe-2S] cluster to sense intracellular iron homeostasis in Escherichia coli	41
The Cdk8 kinase module regulates interaction of the mediator complex with RNA polymerase II	41
A suite of mathematical solutions to describe ternary complex formation and their application to targeted protein degradation by heterobifunctional ligands	40
Dipeptidyl peptidase 3 modulates the renin–angiotensin system in mice	40
Decoding molnupiravir-induced mutagenesis in SARS-CoV-2	40
Structural features of the protein kinase domain and targeted binding by small-molecule inhibitors	40
Nuclear receptor phosphorylation in xenobiotic signal transduction	40
African swine fever virus cysteine protease pS273R inhibits pyroptosis by noncanonically cleaving gasdermin D	39
Dissecting the molecular determinants of clinical PARP1 inhibitor selectivity for tankyrase1	39
Regulation of calcium homeostasis and flux between the endoplasmic reticulum and the cytosol	39
Circadian clock, carcinogenesis, chronochemotherapy connections	39
Extended subsite profiling of the pyroptosis effector protein gasdermin D reveals a region recognized by inflammatory caspase-11	39
Liquid–liquid phase separation of full-length prion protein initiates conformational conversion in vitro	39
Emerging roles of DYRK2 in cancer	39
Interactions of ferritin with scavenger receptor class A members	38
Essence determines phenomenon: Assaying the material properties of biological condensates	38
Wild-type sTREM2 blocks Aβ aggregation and neurotoxicity, but the Alzheimer's R47H mutant increases Aβ aggregation	38
Integrin mediates cell entry of the SARS-CoV-2 virus independent of cellular receptor ACE2	38
A natural product compound inhibits coronaviral replication in vitro by binding to the conserved Nsp9 SARS-CoV-2 protein	38
Early nucleolar responses differentiate mechanisms of cell death induced by oxaliplatin and cisplatin	38
NSun2 promotes cell migration through methylating autotaxin mRNA	38
S-acylation of SARS-CoV-2 spike protein: Mechanistic dissection, in vitro reconstitution and role in viral infectivity	38
Biochemistry of nicotine metabolism and its relevance to lung cancer	38

Moving beyond static snapshots: Protein dynamics and the Protein Data Bank	38
Design of a highly thermotolerant, immunogenic SARS-CoV-2 spike fragment	37
X-ray–induced photoreduction of heme metal centers rapidly induces active-site perturbations in a protein-independent manner	37
The transcription factor HAND2 up-regulates transcription of the IL15 gene in human endometrial stromal cells	37
The therapeutic potential of inhibiting PPARγ phosphorylation to treat type 2 diabetes	37
Receptor binding, immune escape, and protein stability direct the natural selection of SARS-CoV-2 variants	37
Ligand bias in receptor tyrosine kinase signaling	37
Protein interaction networks in neurodegenerative diseases: From physiological function to aggregation	37
Glycosyltransferase ST6Gal-I promotes the epithelial to mesenchymal transition in pancreatic cancer cells	37
Synthetic thick filaments: A new avenue for better understanding the myosin super-relaxed state in healthy, diseased, and mavacamten-treated cardiac systems	37
Modeling the CRL4A ligase complex to predict target protein ubiquitination induced by cereblon-recruiting PROTACs	37
Structure, function, and substrates of Clp AAA+ protease systems in cyanobacteria, plastids, and apicoplasts: A comparative analysis	36
The complement cascade in the regulation of neuroinflammation, nociceptive sensitization, and pain	36
Selective coactivation of α7- and α4β2-nicotinic acetylcholine receptors reverses beta-amyloid–induced synaptic dysfunction	36
Helicobacter pylori infection downregulates the DNA glycosylase NEIL2, resulting in increased genome damage and inflammation in gastric epithelial cells	36
Inflammation promotes adipocyte lipolysis via IRE1 kinase	36
Structure of a monomeric photosystem II core complex from a cyanobacterium acclimated to far-red light reveals the functions of chlorophylls d and f	36
Is γ-secretase a beneficial inactivating enzyme of the toxic APP C-terminal fragment C99?	36
Role of long noncoding RNA MEG3/miR-378/GRB2 axis in neuronal autophagy and neurological functional impairment in ischemic stroke	36
MicroRNA-223-3p promotes skeletal muscle regeneration by regulating inflammation in mice	36
AggreCount: an unbiased image analysis tool for identifying and quantifying cellular aggregates in a spatially defined manner	36
Familial Alzheimer’s disease mutations in amyloid protein precursor alter proteolysis by γ-secretase to increase amyloid β-peptides of ≥45 residues	36
Intersection of the ATF6 and XBP1 ER stress pathways in mouse islet cells	35
5′-UTR recruitment of the translation initiation factor eIF4GI or DAP5 drives cap-independent translation of a subset of human mRNAs	35
Insulin signaling requires glucose to promote lipid anabolism in adipocytes	35
Structure, function, and inhibitor targeting of HIV-1 Nef-effector kinase complexes	35
IFITM proteins: Understanding their diverse roles in viral infection, cancer, and immunity	35
Mass spectrometry characterization of light chain fragmentation sites in cardiac AL amyloidosis: insights into the timing of proteolysis	35
DDX3X coordinates host defense against influenza virus by activating the NLRP3 inflammasome and type I interferon response	35
Tumor suppressor p53 promotes ferroptosis in oxidative stress conditions independent of modulation of ferroptosis by p21, CDKs, RB, and E2F	35
Genetic diseases of the Kennedy pathways for membrane synthesis	35
Endosomal cAMP production broadly impacts the cellular phosphoproteome	35
Resveratrol-induced Sirt1 phosphorylation by LKB1 mediates mitochondrial metabolism	35
Interchangeable utilization of metals: New perspectives on the impacts of metal ions employed in ancient and extant biomolecules	34
SARS-CoV-2 accessory protein ORF8 is secreted extracellularly as a glycoprotein homodimer	34
Sphingosine prevents binding of SARS–CoV-2 spike to its cellular receptor ACE2	34
Post-translational control of the long and winding road to cholesterol	34
Structural and kinetic analyses of holothurian sulfated glycans suggest potential treatment for SARS-CoV-2 infection	34
The deubiquitinase USP10 restores PTEN activity and inhibits non–small cell lung cancer cell proliferation	34
Hyperosmotic phase separation: Condensates beyond inclusions, granules and organelles	34
Modulating disease-relevant tau oligomeric strains by small molecules	34
MtcB, a member of the MttB superfamily from the human gut acetogen Eubacterium limosum, is a cobalamin-dependent carnitine demethylase	34
Macrophage polarization state affects lipid composition and the channeling of exogenous fatty acids into endogenous lipid pools	34
Hypoxia drives the assembly of the multienzyme purinosome complex	34
Evaluating angiotensin-converting enzyme 2-mediated SARS-CoV-2 entry across species	34
Oxidative stress induces Z-DNA-binding protein 1–dependent activation of microglia via mtDNA released from retinal pigment epithelial cells	34
The evolution and mechanism of GPCR proton sensing	34
The ubiquitin system affects agronomic plant traits	34
Amino acid–derived defense metabolites from plants: A potential source to facilitate novel antimicrobial development	34
Evolutionary origin and functional diversification of aminotransferases	33
The periodic table of ribonucleotide reductases	33
SARS-CoV-2 (COVID-19) structural and evolutionary dynamicome: Insights into functional evolution and human genomics	33
An atomistic model of the coronavirus replication-transcription complex as a hexamer assembled around nsp15	33
Dysfunctional telomeres trigger cellular senescence mediated by cyclic GMP-AMP synthase	33
Early cleavage of preimplantation embryos is regulated by tRNAGln-TTG–derived small RNAs present in mature spermatozoa	33
Frameworks for targeting RNA with small molecules	33
How the assembly and protection of the bacterial cell envelope depend on cysteine residues	33
Crosstalk between nucleocytoplasmic trafficking and the innate immune response to viral infection	33
Interactome analysis of Caenorhabditis elegans synapses by TurboID-based proximity labeling	33
Exploring the super-relaxed state of myosin in myofibrils from fast-twitch, slow-twitch, and cardiac muscle	33
Understanding a protein fold: The physics, chemistry, and biology of α-helical coiled coils	33
Human ribosomal G-quadruplexes regulate heme bioavailability	33
Enrichment of NPC1-deficient cells with the lipid LBPA stimulates autophagy, improves lysosomal function, and reduces cholesterol storage	33
Direct detection of the myosin super-relaxed state and interacting-heads motif in solution	33
PIP2 regulation of TRPC5 channel activation and desensitization	32
Cation channel conductance and pH gating of the innate immunity factor APOL1 are governed by pore-lining residues within the C-terminal domain	32
The Mitochondrial Ca2+ uniporter is a central regulator of interorganellar Ca2+ transfer and NFAT activation	32
ALS-linked FUS mutations dysregulate G-quadruplex-dependent liquid–liquid phase separation and liquid-to-solid transition	32
Applying gene editing to tailor precise genetic modifications in plants	32
Noninvasive optical detection of granzyme B from natural killer cells with enzyme-activated fluorogenic probes	32
Calcium as a reliable marker for the quantitative assessment of endoplasmic reticulum stress in live cells	32
Prevalence and species distribution of the low-complexity, amyloid-like, reversible, kinked segment structural motif in amyloid-like fibrils	32
The RNA-binding protein PTBP1 promotes ATPase-dependent dissociation of the RNA helicase UPF1 to protect transcripts from nonsense-mediated mRNA decay	32
Maturation, inactivation, and recovery mechanisms of soluble guanylyl cyclase	32
Obesity-associated microbiota contributes to mucus layer defects in genetically obese mice	32
Targeting all transforming growth factor-β isoforms with an Fc chimeric receptor impairs tumor growth and angiogenesis of oral squamous cell cancer	32
α-Synuclein facilitates endocytosis by elevating the steady-state levels of phosphatidylinositol 4,5-bisphosphate	31
Replication protein A binds RNA and promotes R-loop formation	31
Nrf2 is activated by disruption of mitochondrial thiol homeostasis but not by enhanced mitochondrial superoxide production	31
A combinatorial native MS and LC-MS/MS approach reveals high intrinsic phosphorylation of human Tau but minimal levels of other key modifications	31
The mitochondrial metal transporters mitoferrin1 and mitoferrin2 are required for liver regeneration and cell proliferation in mice	31
Cryo-electron microscopy structure and potential enzymatic function of human six-transmembrane epithelial antigen of the prostate 1 (STEAP1)	31
The unfoldase ClpC1 of Mycobacterium tuberculosis regulates the expression of a distinct subset of proteins having intrinsically disordered termini	31
The tetraspanin Tspan15 is an essential subunit of an ADAM10 scissor complex	31
N-acetylglucosamine drives myelination by triggering oligodendrocyte precursor cell differentiation	31
Fibrillar α-synuclein toxicity depends on functional lysosomes	31
The Natural Product Domain Seeker version 2 (NaPDoS2) webtool relates ketosynthase phylogeny to biosynthetic function	31
The Ca2+ channel CatSper is not activated by cAMP/PKA signaling but directly affected by chemicals used to probe the action of cAMP and PKA	31
Loss of O-GlcNAcase catalytic activity leads to defects in mouse embryogenesis	31
Talin mechanosensitivity is modulated by a direct interaction with cyclin-dependent kinase-1	31
Cryo-electron microscopy structure of the glucagon receptor with a dual-agonist peptide	31
Hyper-truncated Asn355- and Asn391-glycans modulate the activity of neutrophil granule myeloperoxidase	31
ApoC-III is a novel inducer of calcification in human aortic valves	31
High-affinity TrkA and p75 neurotrophin receptor complexes: A twisted affair	31
The RNA-binding protein FUS is chaperoned and imported into the nucleus by a network of import receptors	31