Journal of Biological Chemistry

Article	Citations
Remdesivir is a direct-acting antiviral that inhibits RNA-dependent RNA polymerase from severe acute respiratory syndrome coronavirus 2 with high potency	704
The antiviral compound remdesivir potently inhibits RNA-dependent RNA polymerase from Middle East respiratory syndrome coronavirus	577
The molecular virology of coronaviruses	357
Mechanisms of evolved herbicide resistance	318
SARS-CoV-2 infects cells after viral entry via clathrin-mediated endocytosis	303
Ethylene signaling in plants	284
Inhibition of SARS–CoV-2 by type I and type III interferons	207
The SARS-CoV-2 envelope and membrane proteins modulate maturation and retention of the spike protein, allowing assembly of virus-like particles	201
Molnupiravir promotes SARS-CoV-2 mutagenesis via the RNA template	195
Oxygen battle in the gut: Hypoxia and hypoxia-inducible factors in metabolic and inflammatory responses in the intestine	173
Biosynthesis of the modified tetrapyrroles—the pigments of life	164
Brain manganese and the balance between essential roles and neurotoxicity	164
Antisense technology: A review	150
Structural and functional conservation of the programmed −1 ribosomal frameshift signal of SARS coronavirus 2 (SARS-CoV-2)	144
Impaired NLRP3 inflammasome activation/pyroptosis leads to robust inflammatory cell death via caspase-8/RIPK3 during coronavirus infection	138
The essential elements of Alzheimer’s disease	136
Zinc transporters and their functional integration in mammalian cells	123
Recent advances in de novo protein design: Principles, methods, and applications	119
Major advances in targeted protein degradation: PROTACs, LYTACs, and MADTACs	118
Coronavirus infection and PARP expression dysregulate the NAD metabolome: An actionable component of innate immunity	117
Post-translational modifications of Hsp90 and translating the chaperone code	116
Template-dependent inhibition of coronavirus RNA-dependent RNA polymerase by remdesivir reveals a second mechanism of action	115
Post-translational modifications of Hsp70 family proteins: Expanding the chaperone code	102
The emerging role of α-synuclein truncation in aggregation and disease	99
Mechanisms of adhesion G protein–coupled receptor activation	99

The interplay of fibroblasts, the extracellular matrix, and inflammation in scar formation	98
The chaperone GRP78 is a host auxiliary factor for SARS-CoV-2 and GRP78 depleting antibody blocks viral entry and infection	95
The Zα2 domain of ZBP1 is a molecular switch regulating influenza-induced PANoptosis and perinatal lethality during development	95
Disassembly of Tau fibrils by the human Hsp70 disaggregation machinery generates small seeding-competent species	93
Unusual zwitterionic catalytic site of SARS–CoV-2 main protease revealed by neutron crystallography	93
ZBP1 promotes fungi-induced inflammasome activation and pyroptosis, apoptosis, and necroptosis (PANoptosis)	92
Lipopolysaccharide O-antigens—bacterial glycans made to measure	91
Mitochondrial metabolism regulates macrophage biology	90
CRISPR-Cas12a has widespread off-target and dsDNA-nicking effects	88
N6-Methyladenosine modification of hepatitis B and C viral RNAs attenuates host innate immunity via RIG-I signaling	87
Role of the lipid bilayer in outer membrane protein folding in Gram-negative bacteria	87
The 89-kDa PARP1 cleavage fragment serves as a cytoplasmic PAR carrier to induce AIF-mediated apoptosis	86
Piezo1 acts upstream of TRPV4 to induce pathological changes in endothelial cells due to shear stress	85
The SARS-CoV-2 Y453F mink variant displays a pronounced increase in ACE-2 affinity but does not challenge antibody neutralization	85
Structural basis for the in vitro efficacy of nirmatrelvir against SARS-CoV-2 variants	85
1,6-Hexanediol, commonly used to dissolve liquid–liquid phase separated condensates, directly impairs kinase and phosphatase activities	83
A molecular roadmap to the plant immune system	83
The importance of thiamine (vitamin B1) in plant health: From crop yield to biofortification	81
Zinc promotes liquid–liquid phase separation of tau protein	81
Discovery of amivantamab (JNJ-61186372), a bispecific antibody targeting EGFR and MET	80
Raffinose synthase enhances drought tolerance through raffinose synthesis or galactinol hydrolysis in maize and Arabidopsis plants	79
SARS-CoV-2 viral budding and entry can be modeled using BSL-2 level virus-like particles	77
High affinity binding of SARS-CoV-2 spike protein enhances ACE2 carboxypeptidase activity	73
Toward the solution of the protein structure prediction problem	72
From OCR and ECAR to energy: Perspectives on the design and interpretation of bioenergetics studies	71
Small molecule strategies to harness the unfolded protein response: where do we go from here?	70
The spike protein of SARS-CoV-2 induces endothelial inflammation through integrin α5β1 and NF-κB signaling	70
Deubiquitinating enzymes (DUBs): Regulation, homeostasis, and oxidative stress response	68
Acidity and nucleophilic reactivity of glutathione persulfide	68
Seeing beyond the limit: A guide to choosing the right super-resolution microscopy technique	68
Presence of hyaluronan in lung alveoli in severe Covid-19: An opening for new treatment options?	67
Role of host factors in SARS-CoV-2 entry	67
Exploring cellular biochemistry with nanobodies	65
The mitochondria-targeted peptide SS-31 binds lipid bilayers and modulates surface electrostatics as a key component of its mechanism of action	64
Bacterial iron detoxification at the molecular level	63
Targeting mitophagy in Parkinson's disease	63
Inhibition of acid sphingomyelinase by ambroxol prevents SARS-CoV-2 entry into epithelial cells	62
Iron homeostasis and plant immune responses: Recent insights and translational implications	62
Exosome-mediated mRNA delivery in vivo is safe and can be used to induce SARS-CoV-2 immunity	61
Molecular mechanisms of telomere biology disorders	58
The SARS-CoV-2 Nsp3 macrodomain reverses PARP9/DTX3L-dependent ADP-ribosylation induced by interferon signaling	58
Super-rapid quantitation of the production of HIV-1 harboring a luminescent peptide tag	57
Heterotrimeric Gq proteins as therapeutic targets?	57
Adipose mesenchymal stem cell-derived extracellular vesicles containing microRNA-26a-5p target TLR4 and protect against diabetic nephropathy	56
Structural analysis of carbohydrate binding by the macrophage mannose receptor CD206	56
The structural features that distinguish PD-L2 from PD-L1 emerged in placental mammals	56
Priming of SARS-CoV-2 S protein by several membrane-bound serine proteinases could explain enhanced viral infectivity and systemic COVID-19 infection	56
The binding of heparin to spike glycoprotein inhibits SARS-CoV-2 infection by three mechanisms	55
Emerging roles for R-loop structures in the management of topological stress	55
Sodium-glucose cotransporter-2 inhibitors: Understanding the mechanisms for therapeutic promise and persisting risks	55

Multiple variants of the fungal effector AVR-Pik bind the HMA domain of the rice protein OsHIPP19, providing a foundation to engineer plant defense	55
Bilirubin remodels murine white adipose tissue by reshaping mitochondrial activity and the coregulator profile of peroxisome proliferator–activated receptor α	55
Adaptation of influenza viruses to human airway receptors	55
Structure and function of the ecto-nucleotide pyrophosphatase/phosphodiesterase (ENPP) family: Tidying up diversity	55
Flagging fusion: Phosphatidylserine signaling in cell–cell fusion	54
Truncation of Tau selectively facilitates its pathological activities	54
Regulation and function of the mammalian tricarboxylic acid cycle	54
Ferroptosis drives photoreceptor degeneration in mice with defects in all-trans-retinal clearance	53
Structural insights into emergent signaling modes of G protein–coupled receptors	53
The m6A methyltransferase METTL3 modifies PGC-1α mRNA promoting mitochondrial dysfunction and oxLDL-induced inflammation in monocytes	52
Viperin: An ancient radical SAM enzyme finds its place in modern cellular metabolism and innate immunity	52
Genetic glycoengineering in mammalian cells	52
There’s more to death than life: Noncatalytic functions in kinase and pseudokinase signaling	52
Regulation of tau internalization, degradation, and seeding by LRP1 reveals multiple pathways for tau catabolism	52
From overnutrition to liver injury: AMP-activated protein kinase in nonalcoholic fatty liver diseases	50
Inhibition of the epigenetic suppressor EZH2 primes osteogenic differentiation mediated by BMP2	50
From structure to the dynamic regulation of a molecular switch: A journey over 3 decades	50
Sialic acid O-acetylation: From biosynthesis to roles in health and disease	49
Redesigning plant cell walls for the biomass-based bioeconomy	48
Survivin in breast cancer–derived exosomes activates fibroblasts by up-regulating SOD1, whose feedback promotes cancer proliferation and metastasis	48
Malaria parasite plasmepsins: More than just plain old degradative pepsins	47
African swine fever virus protein MGF-505-7R promotes virulence and pathogenesis by inhibiting JAK1- and JAK2-mediated signaling	47
Gallic acid is a dual α/β-secretase modulator that reverses cognitive impairment and remediates pathology in Alzheimer mice	47
Chemistry of Class 1 CRISPR-Cas effectors: Binding, editing, and regulation	47
ATP13A3 is a major component of the enigmatic mammalian polyamine transport system	46
Update and nomenclature proposal for mammalian lysophospholipid acyltransferases, which create membrane phospholipid diversity	46
IACS-010759, a potent inhibitor of glycolysis-deficient hypoxic tumor cells, inhibits mitochondrial respiratory complex I through a unique mechanism	46
From integrative structural biology to cell biology	46
D614G mutation in the SARS-CoV-2 spike protein enhances viral fitness by desensitizing it to temperature-dependent denaturation	45
GAPDH delivers heme to soluble guanylyl cyclase	45
Arginine methylation of SARS-Cov-2 nucleocapsid protein regulates RNA binding, its ability to suppress stress granule formation, and viral replication	45
Identification of an anti–SARS–CoV-2 receptor-binding domain–directed human monoclonal antibody from a naïve semisynthetic library	44
Templated folding of intrinsically disordered proteins	44
Phase separation by the SARS-CoV-2 nucleocapsid protein: Consensus and open questions	44
H2S and reactive sulfur signaling at the host-bacterial pathogen interface	44
Metabolic regulation of ferroptosis in the tumor microenvironment	44
The transcription factor BACH1 at the crossroads of cancer biology: From epithelial–mesenchymal transition to ferroptosis	44
The stress response protein REDD1 promotes diabetes-induced oxidative stress in the retina by Keap1-independent Nrf2 degradation	44
In vivo two-photon microscopy reveals the contribution of Sox9+ cell to kidney regeneration in a mouse model with extracellular vesicle treatment	43
Crystal structure of a human plasma membrane phospholipid flippase	43
Genetic and biased agonist-mediated reductions in β-arrestin recruitment prolong cAMP signaling at glucagon family receptors	43
The role of the histone H3 variant CENPA in prostate cancer	43
Folding or holding?—Hsp70 and Hsp90 chaperoning of misfolded proteins in neurodegenerative disease	42
How repertoire data are changing antibody science	42
Cytosolic, but not matrix, calcium is essential for adjustment of mitochondrial pyruvate supply	42
Two distinct trophectoderm lineage stem cells from human pluripotent stem cells	42
Engineering acyl-homoserine lactone-interfering enzymes toward bacterial control	42
The detection and functions of RNA modification m6A based on m6A writers and erasers	42
Metabolite sensing and signaling in cancer	42
Biological and catalytic functions of sirtuin 6 as targets for small-molecule modulators	42
Structure, mechanism, and regulation of mitochondrial DNA transcription initiation	42
Highlighting membrane protein structure and function: A celebration of the Protein Data Bank	41
Effective delivery of STING agonist using exosomes suppresses tumor growth and enhances antitumor immunity	41
HIV-cell membrane fusion intermediates are restricted by Serincs as revealed by cryo-electron and TIRF microscopy	41
Emerging roles of the MAGE protein family in stress response pathways	41
Findings in redox biology: From H2O2 to oxidative stress	40
Runt-related transcription factor 1 is required for murine osteoblast differentiation and bone formation	40
Interplay between primary familial brain calcification-associated SLC20A2 and XPR1 phosphate transporters requires inositol polyphosphates for control of cellular phosphate homeostasis	40
TET-mediated 5-methylcytosine oxidation in tRNA promotes translation	40
The scrambled story between hyaluronan and glioblastoma	40
The many lives of type IA topoisomerases	40
PDLIM5 inhibits STUB1-mediated degradation of SMAD3 and promotes the migration and invasion of lung cancer cells	40
Phase separation drives decision making in cell division	40
Famotidine inhibits toll-like receptor 3-mediated inflammatory signaling in SARS-CoV-2 infection	40
The role of PLCγ2 in immunological disorders, cancer, and neurodegeneration	39
A RIG-I–like receptor directs antiviral responses to a bunyavirus and is antagonized by virus-induced blockade of TRIM25-mediated ubiquitination	39
Impact of temperature on the affinity of SARS-CoV-2 Spike glycoprotein for host ACE2	39
Genetic lineage tracing with multiple DNA recombinases: A user's guide for conducting more precise cell fate mapping studies	39
Flavonols modulate lateral root emergence by scavenging reactive oxygen species in Arabidopsis thaliana	39
Autolysosomal degradation of cytosolic chromatin fragments antagonizes oxidative stress–induced senescence	39
A suite of mathematical solutions to describe ternary complex formation and their application to targeted protein degradation by heterobifunctional ligands	38
Evolution, expression, and substrate specificities of aldehyde oxidase enzymes in eukaryotes	38
Strategies for site-specific recombination with high efficiency and precise spatiotemporal resolution	38
Inhibition of the polyamine synthesis enzyme ornithine decarboxylase sensitizes triple-negative breast cancer cells to cytotoxic chemotherapy	38
The testis-specific LINC component SUN3 is essential for sperm head shaping during mouse spermiogenesis	38
Major tail proteins of bacteriophages of the order Caudovirales	38
Functional diversity between HSP70 paralogs caused by variable interactions with specific co-chaperones	38
Ferric uptake regulator (Fur) reversibly binds a [2Fe-2S] cluster to sense intracellular iron homeostasis in Escherichia coli	38
Vestigial-like family member 3 (VGLL3), a cofactor for TEAD transcription factors, promotes cancer cell proliferation by activating the Hippo pathway	38
Translational regulation of environmental adaptation in bacteria	38

Design of a highly thermotolerant, immunogenic SARS-CoV-2 spike fragment	37
Nuclear receptor phosphorylation in xenobiotic signal transduction	37
The secreted protein DEL-1 activates a β3 integrin–FAK–ERK1/2–RUNX2 pathway and promotes osteogenic differentiation and bone regeneration	37
A shared, stochastic pathway mediates exosome protein budding along plasma and endosome membranes	37
Decoding molnupiravir-induced mutagenesis in SARS-CoV-2	37
A flexible network of vimentin intermediate filaments promotes migration of amoeboid cancer cells through confined environments	37
Bile acid sequestration reverses liver injury and prevents progression of nonalcoholic steatohepatitis in Western diet–fed mice	37
Manganese promotes α-synuclein amyloid aggregation through the induction of protein phase transition	36
The biofilm adhesion protein Aap from Staphylococcus epidermidis forms zinc-dependent amyloid fibers	36
Canonical Notch ligands and Fringes have distinct effects on NOTCH1 and NOTCH2	36
Biochemistry of nicotine metabolism and its relevance to lung cancer	36
Interactions of ferritin with scavenger receptor class A members	36
Structural and molecular basis for the substrate positioning mechanism of a new PL7 subfamily alginate lyase from the arctic	36
Cardiac myosin contraction and mechanotransduction in health and disease	36
The therapeutic potential of inhibiting PPARγ phosphorylation to treat type 2 diabetes	35
Sphingosine kills bacteria by binding to cardiolipin	35
Glycosyltransferase ST6Gal-I promotes the epithelial to mesenchymal transition in pancreatic cancer cells	35
Mechanisms tailoring the expression of heat shock proteins to proteostasis challenges	35
Synthetic thick filaments: A new avenue for better understanding the myosin super-relaxed state in healthy, diseased, and mavacamten-treated cardiac systems	35
S-acylation of SARS-CoV-2 spike protein: Mechanistic dissection, in vitro reconstitution and role in viral infectivity	35
A natural product compound inhibits coronaviral replication in vitro by binding to the conserved Nsp9 SARS-CoV-2 protein	35
Role of long noncoding RNA MEG3/miR-378/GRB2 axis in neuronal autophagy and neurological functional impairment in ischemic stroke	35
Dipeptidyl peptidase 3 modulates the renin–angiotensin system in mice	35
Receptor binding, immune escape, and protein stability direct the natural selection of SARS-CoV-2 variants	35
Liquid–liquid phase separation of full-length prion protein initiates conformational conversion in vitro	35
Emerging roles of DYRK2 in cancer	35
Genetic diseases of the Kennedy pathways for membrane synthesis	35
Endosomal cAMP production broadly impacts the cellular phosphoproteome	35
The short variant of optic atrophy 1 (OPA1) improves cell survival under oxidative stress	35
Integrin mediates cell entry of the SARS-CoV-2 virus independent of cellular receptor ACE2	35
Familial Alzheimer’s disease mutations in amyloid protein precursor alter proteolysis by γ-secretase to increase amyloid β-peptides of ≥45 residues	34
The E3 ubiquitin ligase STUB1 attenuates cell senescence by promoting the ubiquitination and degradation of the core circadian regulator BMAL1	34
Thioredoxin regulates human mercaptopyruvate sulfurtransferase at physiologically-relevant concentrations	34
DDX3X coordinates host defense against influenza virus by activating the NLRP3 inflammasome and type I interferon response	34
The circadian clock shapes the Arabidopsis transcriptome by regulating alternative splicing and alternative polyadenylation	34
Modulating disease-relevant tau oligomeric strains by small molecules	34
MicroRNA-223-3p promotes skeletal muscle regeneration by regulating inflammation in mice	34
Helicobacter pylori infection downregulates the DNA glycosylase NEIL2, resulting in increased genome damage and inflammation in gastric epithelial cells	34
Myricetin slows liquid–liquid phase separation of Tau and activates ATG5-dependent autophagy to suppress Tau toxicity	34
Circadian clock, carcinogenesis, chronochemotherapy connections	34
Extended subsite profiling of the pyroptosis effector protein gasdermin D reveals a region recognized by inflammatory caspase-11	34
Dissecting the molecular determinants of clinical PARP1 inhibitor selectivity for tankyrase1	33
X-ray–induced photoreduction of heme metal centers rapidly induces active-site perturbations in a protein-independent manner	33
NSun2 promotes cell migration through methylating autotaxin mRNA	33
Intersection of the ATF6 and XBP1 ER stress pathways in mouse islet cells	33
African swine fever virus cysteine protease pS273R inhibits pyroptosis by noncanonically cleaving gasdermin D	33
SARS-CoV-2 (COVID-19) structural and evolutionary dynamicome: Insights into functional evolution and human genomics	33
Moving beyond static snapshots: Protein dynamics and the Protein Data Bank	33
The deubiquitinase USP10 restores PTEN activity and inhibits non–small cell lung cancer cell proliferation	33
The structure of the extracellular domains of human interleukin 11α receptor reveals mechanisms of cytokine engagement	33
The human mitochondrial 12S rRNA m4C methyltransferase METTL15 is required for mitochondrial function	33
The luminescent HiBiT peptide enables selective quantitation of G protein–coupled receptor ligand engagement and internalization in living cells	33
Early nucleolar responses differentiate mechanisms of cell death induced by oxaliplatin and cisplatin	33
The Cdk8 kinase module regulates interaction of the mediator complex with RNA polymerase II	33
High cell density increases glioblastoma cell viability under glucose deprivation via degradation of the cystine/glutamate transporter xCT (SLC7A11)	33
Inflammation promotes adipocyte lipolysis via IRE1 kinase	33
Early cleavage of preimplantation embryos is regulated by tRNAGln-TTG–derived small RNAs present in mature spermatozoa	32
Structure, function, and substrates of Clp AAA+ protease systems in cyanobacteria, plastids, and apicoplasts: A comparative analysis	32
Wild-type sTREM2 blocks Aβ aggregation and neurotoxicity, but the Alzheimer's R47H mutant increases Aβ aggregation	32
Co-targeting of CXCR4 and hedgehog pathways disrupts tumor-stromal crosstalk and improves chemotherapeutic efficacy in pancreatic cancer	32
Maturation, inactivation, and recovery mechanisms of soluble guanylyl cyclase	32
Structure, function, and inhibitor targeting of HIV-1 Nef-effector kinase complexes	32
Suramin exposure alters cellular metabolism and mitochondrial energy production in African trypanosomes	32
Sphingosine prevents binding of SARS–CoV-2 spike to its cellular receptor ACE2	32
Noninvasive optical detection of granzyme B from natural killer cells with enzyme-activated fluorogenic probes	32
Modeling the CRL4A ligase complex to predict target protein ubiquitination induced by cereblon-recruiting PROTACs	32
The transcription factor HAND2 up-regulates transcription of the IL15 gene in human endometrial stromal cells	32
Resveratrol-induced Sirt1 phosphorylation by LKB1 mediates mitochondrial metabolism	32
5′-UTR recruitment of the translation initiation factor eIF4GI or DAP5 drives cap-independent translation of a subset of human mRNAs	32
Mass spectrometry characterization of light chain fragmentation sites in cardiac AL amyloidosis: insights into the timing of proteolysis	32
Phosphorylation-dependent substrate selectivity of protein kinase B (AKT1)	32
Acquisition of exogenous fatty acids renders apicoplast-based biosynthesis dispensable in tachyzoites of Toxoplasma	32
Phosphorylation of the overlooked tyrosine 310 regulates the structure, aggregation, and microtubule- and lipid-binding properties of Tau	32
Hyper-truncated Asn355- and Asn391-glycans modulate the activity of neutrophil granule myeloperoxidase	31
Structure of a monomeric photosystem II core complex from a cyanobacterium acclimated to far-red light reveals the functions of chlorophylls d and f	31
Interactome analysis of Caenorhabditis elegans synapses by TurboID-based proximity labeling	31
Inhibition of glycosphingolipid biosynthesis reverts multidrug resistance by differentially modulating ABC transporters in chronic myeloid leukemias	31
Post-translational control of the long and winding road to cholesterol	31
Human ribosomal G-quadruplexes regulate heme bioavailability	31
Cotranslational folding stimulates programmed ribosomal frameshifting in the alphavirus structural polyprotein	31
Structural basis of the interplay between α-synuclein and Tau in regulating pathological amyloid aggregation	31
Is γ-secretase a beneficial inactivating enzyme of the toxic APP C-terminal fragment C99?	31
Protein interaction networks in neurodegenerative diseases: From physiological function to aggregation	31
Structural features of the protein kinase domain and targeted binding by small-molecule inhibitors	31
Prevalence and species distribution of the low-complexity, amyloid-like, reversible, kinked segment structural motif in amyloid-like fibrils	31
MtcB, a member of the MttB superfamily from the human gut acetogen Eubacterium limosum, is a cobalamin-dependent carnitine demethylase	31
The ubiquitin system affects agronomic plant traits	31
Structural and kinetic analyses of holothurian sulfated glycans suggest potential treatment for SARS-CoV-2 infection	31
The RNA-binding protein PTBP1 promotes ATPase-dependent dissociation of the RNA helicase UPF1 to protect transcripts from nonsense-mediated mRNA decay	31
An atomistic model of the coronavirus replication-transcription complex as a hexamer assembled around nsp15	31
Dysfunctional telomeres trigger cellular senescence mediated by cyclic GMP-AMP synthase	31
Hyperosmotic phase separation: Condensates beyond inclusions, granules and organelles	31
The tetraspanin Tspan15 is an essential subunit of an ADAM10 scissor complex	31
Cryo-electron microscopy structure of the glucagon receptor with a dual-agonist peptide	31
Amino acid–derived defense metabolites from plants: A potential source to facilitate novel antimicrobial development	31