Journal of Biological Chemistry

Article	Citations
SARS-CoV-2 infects cells after viral entry via clathrin-mediated endocytosis	347
The SARS-CoV-2 envelope and membrane proteins modulate maturation and retention of the spike protein, allowing assembly of virus-like particles	219
Molnupiravir promotes SARS-CoV-2 mutagenesis via the RNA template	213
Antisense technology: A review	192
The essential elements of Alzheimer’s disease	170
The interplay of fibroblasts, the extracellular matrix, and inflammation in scar formation	156
Zinc transporters and their functional integration in mammalian cells	147
Recent advances in de novo protein design: Principles, methods, and applications	146
Major advances in targeted protein degradation: PROTACs, LYTACs, and MADTACs	136
Mitochondrial metabolism regulates macrophage biology	127
Coronavirus infection and PARP expression dysregulate the NAD metabolome: An actionable component of innate immunity	126
Template-dependent inhibition of coronavirus RNA-dependent RNA polymerase by remdesivir reveals a second mechanism of action	123
ZBP1 promotes fungi-induced inflammasome activation and pyroptosis, apoptosis, and necroptosis (PANoptosis)	110
Piezo1 acts upstream of TRPV4 to induce pathological changes in endothelial cells due to shear stress	110
The 89-kDa PARP1 cleavage fragment serves as a cytoplasmic PAR carrier to induce AIF-mediated apoptosis	108
The chaperone GRP78 is a host auxiliary factor for SARS-CoV-2 and GRP78 depleting antibody blocks viral entry and infection	105
1,6-Hexanediol, commonly used to dissolve liquid–liquid phase separated condensates, directly impairs kinase and phosphatase activities	103
Structural basis for the in vitro efficacy of nirmatrelvir against SARS-CoV-2 variants	103
Discovery of amivantamab (JNJ-61186372), a bispecific antibody targeting EGFR and MET	101
Deubiquitinating enzymes (DUBs): Regulation, homeostasis, and oxidative stress response	100
Unusual zwitterionic catalytic site of SARS–CoV-2 main protease revealed by neutron crystallography	99
Regulation and function of the mammalian tricarboxylic acid cycle	95
Seeing beyond the limit: A guide to choosing the right super-resolution microscopy technique	92
The spike protein of SARS-CoV-2 induces endothelial inflammation through integrin α5β1 and NF-κB signaling	91
The SARS-CoV-2 Y453F mink variant displays a pronounced increase in ACE-2 affinity but does not challenge antibody neutralization	89

From OCR and ECAR to energy: Perspectives on the design and interpretation of bioenergetics studies	88
SARS-CoV-2 viral budding and entry can be modeled using BSL-2 level virus-like particles	85
Exosome-mediated mRNA delivery in vivo is safe and can be used to induce SARS-CoV-2 immunity	84
Toward the solution of the protein structure prediction problem	83
High affinity binding of SARS-CoV-2 spike protein enhances ACE2 carboxypeptidase activity	80
Small molecule strategies to harness the unfolded protein response: where do we go from here?	79
Acidity and nucleophilic reactivity of glutathione persulfide	78
Exploring cellular biochemistry with nanobodies	75
The SARS-CoV-2 Nsp3 macrodomain reverses PARP9/DTX3L-dependent ADP-ribosylation induced by interferon signaling	74
Bacterial iron detoxification at the molecular level	74
Targeting mitophagy in Parkinson's disease	73
Role of host factors in SARS-CoV-2 entry	73
Presence of hyaluronan in lung alveoli in severe Covid-19: An opening for new treatment options?	72
The m6A methyltransferase METTL3 modifies PGC-1α mRNA promoting mitochondrial dysfunction and oxLDL-induced inflammation in monocytes	68
Structure and function of the ecto-nucleotide pyrophosphatase/phosphodiesterase (ENPP) family: Tidying up diversity	68
Inhibition of acid sphingomyelinase by ambroxol prevents SARS-CoV-2 entry into epithelial cells	68
Molecular mechanisms of telomere biology disorders	67
Structural analysis of carbohydrate binding by the macrophage mannose receptor CD206	67
Regulation of tau internalization, degradation, and seeding by LRP1 reveals multiple pathways for tau catabolism	65
Adaptation of influenza viruses to human airway receptors	64
Multiple variants of the fungal effector AVR-Pik bind the HMA domain of the rice protein OsHIPP19, providing a foundation to engineer plant defense	64
Priming of SARS-CoV-2 S protein by several membrane-bound serine proteinases could explain enhanced viral infectivity and systemic COVID-19 infection	64
There’s more to death than life: Noncatalytic functions in kinase and pseudokinase signaling	63
From structure to the dynamic regulation of a molecular switch: A journey over 3 decades	63
Genetic glycoengineering in mammalian cells	62
Phase separation by the SARS-CoV-2 nucleocapsid protein: Consensus and open questions	61
Update and nomenclature proposal for mammalian lysophospholipid acyltransferases, which create membrane phospholipid diversity	60
The binding of heparin to spike glycoprotein inhibits SARS-CoV-2 infection by three mechanisms	60
Flagging fusion: Phosphatidylserine signaling in cell–cell fusion	59
Ferroptosis drives photoreceptor degeneration in mice with defects in all-trans-retinal clearance	59
Mechanisms tailoring the expression of heat shock proteins to proteostasis challenges	59
From integrative structural biology to cell biology	58
Structure, mechanism, and regulation of mitochondrial DNA transcription initiation	58
Structural features of the protein kinase domain and targeted binding by small-molecule inhibitors	57
A shared, stochastic pathway mediates exosome protein budding along plasma and endosome membranes	56
ATP13A3 is a major component of the enigmatic mammalian polyamine transport system	55
African swine fever virus protein MGF-505-7R promotes virulence and pathogenesis by inhibiting JAK1- and JAK2-mediated signaling	55
Two distinct trophectoderm lineage stem cells from human pluripotent stem cells	54
Structural basis of nirmatrelvir and ensitrelvir activity against naturally occurring polymorphisms of the SARS-CoV-2 main protease	54
Sialic acid O-acetylation: From biosynthesis to roles in health and disease	54
Arginine methylation of SARS-Cov-2 nucleocapsid protein regulates RNA binding, its ability to suppress stress granule formation, and viral replication	53
Gallic acid is a dual α/β-secretase modulator that reverses cognitive impairment and remediates pathology in Alzheimer mice	53
Metabolic regulation of ferroptosis in the tumor microenvironment	53
The transcription factor BACH1 at the crossroads of cancer biology: From epithelial–mesenchymal transition to ferroptosis	52
Genetic and biased agonist-mediated reductions in β-arrestin recruitment prolong cAMP signaling at glucagon family receptors	51
The detection and functions of RNA modification m6A based on m6A writers and erasers	51
Folding or holding?—Hsp70 and Hsp90 chaperoning of misfolded proteins in neurodegenerative disease	51
TET-mediated 5-methylcytosine oxidation in tRNA promotes translation	50
D614G mutation in the SARS-CoV-2 spike protein enhances viral fitness by desensitizing it to temperature-dependent denaturation	49
Major tail proteins of bacteriophages of the order Caudovirales	49

Effective delivery of STING agonist using exosomes suppresses tumor growth and enhances antitumor immunity	48
Flavonols modulate lateral root emergence by scavenging reactive oxygen species in Arabidopsis thaliana	48
The scrambled story between hyaluronan and glioblastoma	48
The role of PLCγ2 in immunological disorders, cancer, and neurodegeneration	47
Emerging roles of the MAGE protein family in stress response pathways	47
Biochemistry of nicotine metabolism and its relevance to lung cancer	47
Famotidine inhibits toll-like receptor 3-mediated inflammatory signaling in SARS-CoV-2 infection	47
The Cdk8 kinase module regulates interaction of the mediator complex with RNA polymerase II	47
Manganese promotes α-synuclein amyloid aggregation through the induction of protein phase transition	46
Regulation of calcium homeostasis and flux between the endoplasmic reticulum and the cytosol	46
Cardiac myosin contraction and mechanotransduction in health and disease	46
Myricetin slows liquid–liquid phase separation of Tau and activates ATG5-dependent autophagy to suppress Tau toxicity	46
Strategies for site-specific recombination with high efficiency and precise spatiotemporal resolution	45
Essence determines phenomenon: Assaying the material properties of biological condensates	45
HIV-cell membrane fusion intermediates are restricted by Serincs as revealed by cryo-electron and TIRF microscopy	45
Structural and molecular basis for the substrate positioning mechanism of a new PL7 subfamily alginate lyase from the arctic	44
Highlighting membrane protein structure and function: A celebration of the Protein Data Bank	44
NSun2 promotes cell migration through methylating autotaxin mRNA	44
Dissecting the molecular determinants of clinical PARP1 inhibitor selectivity for tankyrase1	44
IFITM proteins: Understanding their diverse roles in viral infection, cancer, and immunity	43
African swine fever virus cysteine protease pS273R inhibits pyroptosis by noncanonically cleaving gasdermin D	43
Protein interaction networks in neurodegenerative diseases: From physiological function to aggregation	43
A suite of mathematical solutions to describe ternary complex formation and their application to targeted protein degradation by heterobifunctional ligands	43
Ligand bias in receptor tyrosine kinase signaling	43
Impact of temperature on the affinity of SARS-CoV-2 Spike glycoprotein for host ACE2	43
Moving beyond static snapshots: Protein dynamics and the Protein Data Bank	43
Liquid–liquid phase separation of full-length prion protein initiates conformational conversion in vitro	42
Circadian clock, carcinogenesis, chronochemotherapy connections	42
Ferric uptake regulator (Fur) reversibly binds a [2Fe-2S] cluster to sense intracellular iron homeostasis in Escherichia coli	42
Integrin mediates cell entry of the SARS-CoV-2 virus independent of cellular receptor ACE2	42
S-acylation of SARS-CoV-2 spike protein: Mechanistic dissection, in vitro reconstitution and role in viral infectivity	42
Emerging roles of DYRK2 in cancer	42
Evolutionary origin and functional diversification of aminotransferases	41
Early nucleolar responses differentiate mechanisms of cell death induced by oxaliplatin and cisplatin	41
Structure, function, and substrates of Clp AAA+ protease systems in cyanobacteria, plastids, and apicoplasts: A comparative analysis	41
Glycosyltransferase ST6Gal-I promotes the epithelial to mesenchymal transition in pancreatic cancer cells	40
Wild-type sTREM2 blocks Aβ aggregation and neurotoxicity, but the Alzheimer's R47H mutant increases Aβ aggregation	40
Nuclear receptor phosphorylation in xenobiotic signal transduction	40
Structure of a monomeric photosystem II core complex from a cyanobacterium acclimated to far-red light reveals the functions of chlorophylls d and f	40
Interchangeable utilization of metals: New perspectives on the impacts of metal ions employed in ancient and extant biomolecules	40
High-affinity TrkA and p75 neurotrophin receptor complexes: A twisted affair	40
Decoding molnupiravir-induced mutagenesis in SARS-CoV-2	40
Modeling the CRL4A ligase complex to predict target protein ubiquitination induced by cereblon-recruiting PROTACs	40
Selective coactivation of α7- and α4β2-nicotinic acetylcholine receptors reverses beta-amyloid–induced synaptic dysfunction	40
Familial Alzheimer’s disease mutations in amyloid protein precursor alter proteolysis by γ-secretase to increase amyloid β-peptides of ≥45 residues	39
The complement cascade in the regulation of neuroinflammation, nociceptive sensitization, and pain	39
Interactions of ferritin with scavenger receptor class A members	39
Understanding a protein fold: The physics, chemistry, and biology of α-helical coiled coils	39
Mass spectrometry characterization of light chain fragmentation sites in cardiac AL amyloidosis: insights into the timing of proteolysis	39
Tumor suppressor p53 promotes ferroptosis in oxidative stress conditions independent of modulation of ferroptosis by p21, CDKs, RB, and E2F	39
A natural product compound inhibits coronaviral replication in vitro by binding to the conserved Nsp9 SARS-CoV-2 protein	39
PIP2 regulation of TRPC5 channel activation and desensitization	39
Receptor binding, immune escape, and protein stability direct the natural selection of SARS-CoV-2 variants	38
The Natural Product Domain Seeker version 2 (NaPDoS2) webtool relates ketosynthase phylogeny to biosynthetic function	38
Oxidative stress induces Z-DNA-binding protein 1–dependent activation of microglia via mtDNA released from retinal pigment epithelial cells	38
The periodic table of ribonucleotide reductases	38
DDX3X coordinates host defense against influenza virus by activating the NLRP3 inflammasome and type I interferon response	38
Inflammation promotes adipocyte lipolysis via IRE1 kinase	38
Amino acid–derived defense metabolites from plants: A potential source to facilitate novel antimicrobial development	38
Is γ-secretase a beneficial inactivating enzyme of the toxic APP C-terminal fragment C99?	38
The therapeutic potential of inhibiting PPARγ phosphorylation to treat type 2 diabetes	38
Understanding the physical basis of memory: Molecular mechanisms of the engram	37
AggreCount: an unbiased image analysis tool for identifying and quantifying cellular aggregates in a spatially defined manner	37
Hyperosmotic phase separation: Condensates beyond inclusions, granules and organelles	37
Design of a highly thermotolerant, immunogenic SARS-CoV-2 spike fragment	37
The deubiquitinase USP10 restores PTEN activity and inhibits non–small cell lung cancer cell proliferation	37
Coming full circle: On the origin and evolution of the looping model for enhancer–promoter communication	37
Synthetic thick filaments: A new avenue for better understanding the myosin super-relaxed state in healthy, diseased, and mavacamten-treated cardiac systems	37
Frameworks for targeting RNA with small molecules	36
An atomistic model of the coronavirus replication-transcription complex as a hexamer assembled around nsp15	36
Resveratrol-induced Sirt1 phosphorylation by LKB1 mediates mitochondrial metabolism	36
Exploring the super-relaxed state of myosin in myofibrils from fast-twitch, slow-twitch, and cardiac muscle	36
Macrophage polarization state affects lipid composition and the channeling of exogenous fatty acids into endogenous lipid pools	36
Endosomal cAMP production broadly impacts the cellular phosphoproteome	36
Obesity-associated microbiota contributes to mucus layer defects in genetically obese mice	36
The cytoprotective protein MANF promotes neuronal survival independently from its role as a GRP78 cofactor	36
Crosstalk between nucleocytoplasmic trafficking and the innate immune response to viral infection	36
Calcium as a reliable marker for the quantitative assessment of endoplasmic reticulum stress in live cells	35
Post-translational control of the long and winding road to cholesterol	35
A combinatorial native MS and LC-MS/MS approach reveals high intrinsic phosphorylation of human Tau but minimal levels of other key modifications	35

Regulation of translation by one-carbon metabolism in bacteria and eukaryotic organelles	35
Interactome analysis of Caenorhabditis elegans synapses by TurboID-based proximity labeling	35
Genetic diseases of the Kennedy pathways for membrane synthesis	35
The evolution and mechanism of GPCR proton sensing	35
ApoC-III is a novel inducer of calcification in human aortic valves	35
Direct detection of the myosin super-relaxed state and interacting-heads motif in solution	35
RNA binding by ADAR3 inhibits adenosine-to-inosine editing and promotes expression of immune response protein MAVS	35
Engineering functional thermostable proteins using ancestral sequence reconstruction	35
Enrichment of NPC1-deficient cells with the lipid LBPA stimulates autophagy, improves lysosomal function, and reduces cholesterol storage	35
Evaluating angiotensin-converting enzyme 2-mediated SARS-CoV-2 entry across species	35
The Mitochondrial Ca2+ uniporter is a central regulator of interorganellar Ca2+ transfer and NFAT activation	34
PRPF19 regulates p53-dependent cellular senescence by modulating alternative splicing of MDM4 mRNA	34
Structural and kinetic analyses of holothurian sulfated glycans suggest potential treatment for SARS-CoV-2 infection	34
SARS-CoV-2 accessory protein ORF8 is secreted extracellularly as a glycoprotein homodimer	34
The small-molecule BMH-21 directly inhibits transcription elongation and DNA occupancy of RNA polymerase I in vivo and in vitro	34
Maturation, inactivation, and recovery mechanisms of soluble guanylyl cyclase	34
Sphingosine prevents binding of SARS–CoV-2 spike to its cellular receptor ACE2	34
Intrinsically disordered regions that drive phase separation form a robustly distinct protein class	34
Loss of O-GlcNAcase catalytic activity leads to defects in mouse embryogenesis	33
The METTL5-TRMT112 N6-methyladenosine methyltransferase complex regulates mRNA translation via 18S rRNA methylation	33
FUS contributes to mTOR-dependent inhibition of translation	33
Revisiting T7 RNA polymerase transcription in vitro with the Broccoli RNA aptamer as a simplified real-time fluorescent reporter	33
Talin mechanosensitivity is modulated by a direct interaction with cyclin-dependent kinase-1	33
A primer to traction force microscopy	33
The copper chaperone CCS facilitates copper binding to MEK1/2 to promote kinase activation	33
MicroRNA-223-3p inhibits vascular calcification and the osteogenic switch of vascular smooth muscle cells	32
Microscale thermophoresis suggests a new model of regulation of cardiac myosin function via interaction with cardiac myosin-binding protein C	32
Hyper-truncated Asn355- and Asn391-glycans modulate the activity of neutrophil granule myeloperoxidase	32
ALS-linked FUS mutations dysregulate G-quadruplex-dependent liquid–liquid phase separation and liquid-to-solid transition	32
Pathways and disease-causing alterations in visual chromophore production for vertebrate vision	32
The RNA-binding protein FUS is chaperoned and imported into the nucleus by a network of import receptors	32
α-Synuclein facilitates endocytosis by elevating the steady-state levels of phosphatidylinositol 4,5-bisphosphate	32
Nrf2 is activated by disruption of mitochondrial thiol homeostasis but not by enhanced mitochondrial superoxide production	32
Lysine 63-linked ubiquitination of tau oligomers contributes to the pathogenesis of Alzheimer’s disease	32
The cell surface hyaluronidase TMEM2 regulates cell adhesion and migration via degradation of hyaluronan at focal adhesion sites	31
Kinetics of H2O2-driven catalysis by a lytic polysaccharide monooxygenase from the fungus Trichoderma reesei	31
Natural variants modify Klebsiella pneumoniae carbapenemase (KPC) acyl–enzyme conformational dynamics to extend antibiotic resistance	31
N-acetylglucosamine drives myelination by triggering oligodendrocyte precursor cell differentiation	31
Glucosylceramide synthase inhibitors prevent replication of SARS-CoV-2 and influenza virus	31
Replication of the coronavirus genome: A paradox among positive-strand RNA viruses	31
Repression of transcription by the glucocorticoid receptor: A parsimonious model for the genomics era	31
Hsp70 chaperone blocks α-synuclein oligomer formation via a novel engagement mechanism	31
Structural basis for allosteric regulation of pyruvate kinase M2 by phosphorylation and acetylation	31
A proteomic atlas of ligand–receptor interactions at the ovine maternal–fetal interface reveals the role of histone lactylation in uterine remodeling	31
Astrocyte-specific deletion of the transcription factor Yin Yang 1 in murine substantia nigra mitigates manganese-induced dopaminergic neurotoxicity	31
Fibrillar α-synuclein toxicity depends on functional lysosomes	31
Regulation of Wnt receptor activity: Implications for therapeutic development in colon cancer	31
Genetic evidence for partial redundancy between the arginine methyltransferases CARM1 and PRMT6	31
Representative cancer-associated U2AF2 mutations alter RNA interactions and splicing	31
Prevalence and species distribution of the low-complexity, amyloid-like, reversible, kinked segment structural motif in amyloid-like fibrils	31
A blueprint for academic laboratories to produce SARS-CoV-2 quantitative RT-PCR test kits	31
A redox cycle with complex II prioritizes sulfide quinone oxidoreductase-dependent H2S oxidation	31
Recent structural insights into the mechanism of ClpP protease regulation by AAA+ chaperones and small molecules	31
A peptide CORO1C-47aa encoded by the circular noncoding RNA circ-0000437 functions as a negative regulator in endometrium tumor angiogenesis	30
Muscle-specific TGR5 overexpression improves glucose clearance in glucose-intolerant mice	30
The cell surface hyaluronidase TMEM2 is essential for systemic hyaluronan catabolism and turnover	30
Multi-transcriptome analysis following an acute skeletal muscle growth stimulus yields tools for discerning global and MYC regulatory networks	30
The long noncoding RNA NARL regulates immune responses via microRNA-mediated NOD1 downregulation in teleost fish	29
Dissecting the low catalytic capability of flavin-dependent halogenases	29
The mitochondrial NADH pool is involved in hydrogen sulfide signaling and stimulation of aerobic glycolysis	29
Cu, Fe, and Zn isotope ratios in murine Alzheimer's disease models suggest specific signatures of amyloidogenesis and tauopathy	29
CaMKK2 is inactivated by cAMP-PKA signaling and 14-3-3 adaptor proteins	29
NETosis occurs independently of neutrophil serine proteases	29
Glycogen-autophagy: Molecular machinery and cellular mechanisms of glycophagy	29
The RNA helicase DHX36–G4R1 modulates C9orf72 GGGGCC hexanucleotide repeat–associated translation	29
Direct evidence that Ataxin-2 is a translational activator mediating cytoplasmic polyadenylation	29
Efficient incorporation and template-dependent polymerase inhibition are major determinants for the broad-spectrum antiviral activity of remdesivir	29
Sex hormones regulate metainflammation in diet-induced obesity in mice	28
Enzymatic dispersion of biofilms: An emerging biocatalytic avenue to combat biofilm-mediated microbial infections	28
The human mitochondrial enzyme BCO2 exhibits catalytic activity toward carotenoids and apocarotenoids	28
Microtubule affinity–regulating kinase 4 with an Alzheimer's disease-related mutation promotes tau accumulation and exacerbates neurodegeneration	28
Hydrophilic loop 1 of Presenilin-1 and the APP GxxxG transmembrane motif regulate γ-secretase function in generating Alzheimer-causing Aβ peptides	28
Branched-chain amino acid metabolism controls membrane phospholipid structure in Staphylococcus aureus	28
Bidirectional epithelial–mesenchymal crosstalk provides self-sustaining profibrotic signals in pulmonary fibrosis	28
Role of substrate recognition in modulating strigolactone receptor selectivity in witchweed	28
Cross-seeding of alpha-synuclein aggregation by amyloid fibrils of food proteins	28
Branched-chain ketoacid overload inhibits insulin action in the muscle	28
Metformin inhibits MAPK signaling and rescues pancreatic aquaporin 7 expression to induce insulin secretion in type 2 diabetes mellitus	28
Post-translational regulation of the major drug transporters in the families of organic anion transporters and organic anion–transporting polypeptides	28
Mutant BIN1-Dynamin 2 complexes dysregulate membrane remodeling in the pathogenesis of centronuclear myopathy	28
Reconstitution of the SARS-CoV-2 ribonucleosome provides insights into genomic RNA packaging and regulation by phosphorylation	28
Deciphering the evolution of metallo-β-lactamases: A journey from the test tube to the bacterial periplasm	28
YAP contributes to DNA methylation remodeling upon mouse embryonic stem cell differentiation	28
Gasdermin E is required for induction of pyroptosis and severe disease during enterovirus 71 infection	28
Protein kinase C fusion proteins are paradoxically loss of function in cancer	28
Adaptive and maladaptive roles for ChREBP in the liver and pancreatic islets	28
Structural details of amyloid β oligomers in complex with human prion protein as revealed by solid-state MAS NMR spectroscopy	28
The CFTR P67L variant reveals a key role for N-terminal lasso helices in channel folding, maturation, and pharmacologic rescue	28
Vitamin D receptor inhibits EMT via regulation of the epithelial mitochondrial function in intestinal fibrosis	28
GPNMB plays a protective role against obesity-related metabolic disorders by reducing macrophage inflammatory capacity	28
p53 regulates skeletal muscle mitophagy and mitochondrial quality control following denervation-induced muscle disuse	27
The extensive and functionally uncharacterized mitochondrial phosphoproteome	27
Mechanistic origin of partial agonism of tetrahydrocannabinol for cannabinoid receptors	27
Allosteric activation of proto-oncogene kinase Src by GPCR–beta-arrestin complexes	27
Coordinate regulation of systemic and kidney tryptophan metabolism by the drug transporters OAT1 and OAT3	27