Journal of Biological Chemistry

(The median citation count of Journal of Biological Chemistry is 1. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-04-01 to 2024-04-01.)
Remdesivir is a direct-acting antiviral that inhibits RNA-dependent RNA polymerase from severe acute respiratory syndrome coronavirus 2 with high potency704
The antiviral compound remdesivir potently inhibits RNA-dependent RNA polymerase from Middle East respiratory syndrome coronavirus577
The molecular virology of coronaviruses357
Mechanisms of evolved herbicide resistance318
SARS-CoV-2 infects cells after viral entry via clathrin-mediated endocytosis303
Ethylene signaling in plants284
Inhibition of SARS–CoV-2 by type I and type III interferons207
The SARS-CoV-2 envelope and membrane proteins modulate maturation and retention of the spike protein, allowing assembly of virus-like particles201
Molnupiravir promotes SARS-CoV-2 mutagenesis via the RNA template195
Oxygen battle in the gut: Hypoxia and hypoxia-inducible factors in metabolic and inflammatory responses in the intestine173
Biosynthesis of the modified tetrapyrroles—the pigments of life164
Brain manganese and the balance between essential roles and neurotoxicity164
Antisense technology: A review150
Structural and functional conservation of the programmed −1 ribosomal frameshift signal of SARS coronavirus 2 (SARS-CoV-2)144
Impaired NLRP3 inflammasome activation/pyroptosis leads to robust inflammatory cell death via caspase-8/RIPK3 during coronavirus infection138
The essential elements of Alzheimer’s disease136
Zinc transporters and their functional integration in mammalian cells123
Recent advances in de novo protein design: Principles, methods, and applications119
Major advances in targeted protein degradation: PROTACs, LYTACs, and MADTACs118
Coronavirus infection and PARP expression dysregulate the NAD metabolome: An actionable component of innate immunity117
Post-translational modifications of Hsp90 and translating the chaperone code116
Template-dependent inhibition of coronavirus RNA-dependent RNA polymerase by remdesivir reveals a second mechanism of action115
Post-translational modifications of Hsp70 family proteins: Expanding the chaperone code102
Mechanisms of adhesion G protein–coupled receptor activation99
The emerging role of α-synuclein truncation in aggregation and disease99
The interplay of fibroblasts, the extracellular matrix, and inflammation in scar formation98
The chaperone GRP78 is a host auxiliary factor for SARS-CoV-2 and GRP78 depleting antibody blocks viral entry and infection95
The Zα2 domain of ZBP1 is a molecular switch regulating influenza-induced PANoptosis and perinatal lethality during development95
Disassembly of Tau fibrils by the human Hsp70 disaggregation machinery generates small seeding-competent species93
Unusual zwitterionic catalytic site of SARS–CoV-2 main protease revealed by neutron crystallography93
ZBP1 promotes fungi-induced inflammasome activation and pyroptosis, apoptosis, and necroptosis (PANoptosis)92
Lipopolysaccharide O-antigens—bacterial glycans made to measure91
Mitochondrial metabolism regulates macrophage biology90
CRISPR-Cas12a has widespread off-target and dsDNA-nicking effects88
N6-Methyladenosine modification of hepatitis B and C viral RNAs attenuates host innate immunity via RIG-I signaling87
Role of the lipid bilayer in outer membrane protein folding in Gram-negative bacteria87
The 89-kDa PARP1 cleavage fragment serves as a cytoplasmic PAR carrier to induce AIF-mediated apoptosis86
Piezo1 acts upstream of TRPV4 to induce pathological changes in endothelial cells due to shear stress85
The SARS-CoV-2 Y453F mink variant displays a pronounced increase in ACE-2 affinity but does not challenge antibody neutralization85
Structural basis for the in vitro efficacy of nirmatrelvir against SARS-CoV-2 variants85
1,6-Hexanediol, commonly used to dissolve liquid–liquid phase separated condensates, directly impairs kinase and phosphatase activities83
A molecular roadmap to the plant immune system83
The importance of thiamine (vitamin B1) in plant health: From crop yield to biofortification81
Zinc promotes liquid–liquid phase separation of tau protein81
Discovery of amivantamab (JNJ-61186372), a bispecific antibody targeting EGFR and MET80
Raffinose synthase enhances drought tolerance through raffinose synthesis or galactinol hydrolysis in maize and Arabidopsis plants79
SARS-CoV-2 viral budding and entry can be modeled using BSL-2 level virus-like particles77
High affinity binding of SARS-CoV-2 spike protein enhances ACE2 carboxypeptidase activity73
Toward the solution of the protein structure prediction problem72
From OCR and ECAR to energy: Perspectives on the design and interpretation of bioenergetics studies71
Small molecule strategies to harness the unfolded protein response: where do we go from here?70
The spike protein of SARS-CoV-2 induces endothelial inflammation through integrin α5β1 and NF-κB signaling70
Acidity and nucleophilic reactivity of glutathione persulfide68
Seeing beyond the limit: A guide to choosing the right super-resolution microscopy technique68
Deubiquitinating enzymes (DUBs): Regulation, homeostasis, and oxidative stress response68
Role of host factors in SARS-CoV-2 entry67
Presence of hyaluronan in lung alveoli in severe Covid-19: An opening for new treatment options?67
Exploring cellular biochemistry with nanobodies65
The mitochondria-targeted peptide SS-31 binds lipid bilayers and modulates surface electrostatics as a key component of its mechanism of action64
Bacterial iron detoxification at the molecular level63
Targeting mitophagy in Parkinson's disease63
Inhibition of acid sphingomyelinase by ambroxol prevents SARS-CoV-2 entry into epithelial cells62
Iron homeostasis and plant immune responses: Recent insights and translational implications62
Exosome-mediated mRNA delivery in vivo is safe and can be used to induce SARS-CoV-2 immunity61
Molecular mechanisms of telomere biology disorders58
The SARS-CoV-2 Nsp3 macrodomain reverses PARP9/DTX3L-dependent ADP-ribosylation induced by interferon signaling58
Super-rapid quantitation of the production of HIV-1 harboring a luminescent peptide tag57
Heterotrimeric Gq proteins as therapeutic targets?57
Adipose mesenchymal stem cell-derived extracellular vesicles containing microRNA-26a-5p target TLR4 and protect against diabetic nephropathy56
Structural analysis of carbohydrate binding by the macrophage mannose receptor CD20656
The structural features that distinguish PD-L2 from PD-L1 emerged in placental mammals56
Priming of SARS-CoV-2 S protein by several membrane-bound serine proteinases could explain enhanced viral infectivity and systemic COVID-19 infection56
The binding of heparin to spike glycoprotein inhibits SARS-CoV-2 infection by three mechanisms55
Emerging roles for R-loop structures in the management of topological stress55
Sodium-glucose cotransporter-2 inhibitors: Understanding the mechanisms for therapeutic promise and persisting risks55
Multiple variants of the fungal effector AVR-Pik bind the HMA domain of the rice protein OsHIPP19, providing a foundation to engineer plant defense55
Bilirubin remodels murine white adipose tissue by reshaping mitochondrial activity and the coregulator profile of peroxisome proliferator–activated receptor α55
Adaptation of influenza viruses to human airway receptors55
Structure and function of the ecto-nucleotide pyrophosphatase/phosphodiesterase (ENPP) family: Tidying up diversity55
Flagging fusion: Phosphatidylserine signaling in cell–cell fusion54
Truncation of Tau selectively facilitates its pathological activities54
Regulation and function of the mammalian tricarboxylic acid cycle54
Ferroptosis drives photoreceptor degeneration in mice with defects in all-trans-retinal clearance53
Structural insights into emergent signaling modes of G protein–coupled receptors53
Viperin: An ancient radical SAM enzyme finds its place in modern cellular metabolism and innate immunity52
Genetic glycoengineering in mammalian cells52
There’s more to death than life: Noncatalytic functions in kinase and pseudokinase signaling52
Regulation of tau internalization, degradation, and seeding by LRP1 reveals multiple pathways for tau catabolism52
The m6A methyltransferase METTL3 modifies PGC-1α mRNA promoting mitochondrial dysfunction and oxLDL-induced inflammation in monocytes52
From overnutrition to liver injury: AMP-activated protein kinase in nonalcoholic fatty liver diseases50
Inhibition of the epigenetic suppressor EZH2 primes osteogenic differentiation mediated by BMP250
From structure to the dynamic regulation of a molecular switch: A journey over 3 decades50
Sialic acid O-acetylation: From biosynthesis to roles in health and disease49
Redesigning plant cell walls for the biomass-based bioeconomy48
Survivin in breast cancer–derived exosomes activates fibroblasts by up-regulating SOD1, whose feedback promotes cancer proliferation and metastasis48
Malaria parasite plasmepsins: More than just plain old degradative pepsins47
African swine fever virus protein MGF-505-7R promotes virulence and pathogenesis by inhibiting JAK1- and JAK2-mediated signaling47
Gallic acid is a dual α/β-secretase modulator that reverses cognitive impairment and remediates pathology in Alzheimer mice47
Chemistry of Class 1 CRISPR-Cas effectors: Binding, editing, and regulation47
ATP13A3 is a major component of the enigmatic mammalian polyamine transport system46
Update and nomenclature proposal for mammalian lysophospholipid acyltransferases, which create membrane phospholipid diversity46
IACS-010759, a potent inhibitor of glycolysis-deficient hypoxic tumor cells, inhibits mitochondrial respiratory complex I through a unique mechanism46
From integrative structural biology to cell biology46
D614G mutation in the SARS-CoV-2 spike protein enhances viral fitness by desensitizing it to temperature-dependent denaturation45
GAPDH delivers heme to soluble guanylyl cyclase45
Arginine methylation of SARS-Cov-2 nucleocapsid protein regulates RNA binding, its ability to suppress stress granule formation, and viral replication45
Identification of an anti–SARS–CoV-2 receptor-binding domain–directed human monoclonal antibody from a naïve semisynthetic library44
Templated folding of intrinsically disordered proteins44
Phase separation by the SARS-CoV-2 nucleocapsid protein: Consensus and open questions44
H2S and reactive sulfur signaling at the host-bacterial pathogen interface44
Metabolic regulation of ferroptosis in the tumor microenvironment44
The transcription factor BACH1 at the crossroads of cancer biology: From epithelial–mesenchymal transition to ferroptosis44
The stress response protein REDD1 promotes diabetes-induced oxidative stress in the retina by Keap1-independent Nrf2 degradation44
In vivo two-photon microscopy reveals the contribution of Sox9+ cell to kidney regeneration in a mouse model with extracellular vesicle treatment43
Crystal structure of a human plasma membrane phospholipid flippase43
Genetic and biased agonist-mediated reductions in β-arrestin recruitment prolong cAMP signaling at glucagon family receptors43
The role of the histone H3 variant CENPA in prostate cancer43
Folding or holding?—Hsp70 and Hsp90 chaperoning of misfolded proteins in neurodegenerative disease42
How repertoire data are changing antibody science42
Cytosolic, but not matrix, calcium is essential for adjustment of mitochondrial pyruvate supply42
Two distinct trophectoderm lineage stem cells from human pluripotent stem cells42
Engineering acyl-homoserine lactone-interfering enzymes toward bacterial control42
The detection and functions of RNA modification m6A based on m6A writers and erasers42
Metabolite sensing and signaling in cancer42
Biological and catalytic functions of sirtuin 6 as targets for small-molecule modulators42
Structure, mechanism, and regulation of mitochondrial DNA transcription initiation42
Highlighting membrane protein structure and function: A celebration of the Protein Data Bank41
Effective delivery of STING agonist using exosomes suppresses tumor growth and enhances antitumor immunity41
HIV-cell membrane fusion intermediates are restricted by Serincs as revealed by cryo-electron and TIRF microscopy41
Emerging roles of the MAGE protein family in stress response pathways41
Findings in redox biology: From H2O2 to oxidative stress40
Runt-related transcription factor 1 is required for murine osteoblast differentiation and bone formation40
Interplay between primary familial brain calcification-associated SLC20A2 and XPR1 phosphate transporters requires inositol polyphosphates for control of cellular phosphate homeostasis40
TET-mediated 5-methylcytosine oxidation in tRNA promotes translation40
The scrambled story between hyaluronan and glioblastoma40
The many lives of type IA topoisomerases40
PDLIM5 inhibits STUB1-mediated degradation of SMAD3 and promotes the migration and invasion of lung cancer cells40
Phase separation drives decision making in cell division40
Famotidine inhibits toll-like receptor 3-mediated inflammatory signaling in SARS-CoV-2 infection40
The role of PLCγ2 in immunological disorders, cancer, and neurodegeneration39
A RIG-I–like receptor directs antiviral responses to a bunyavirus and is antagonized by virus-induced blockade of TRIM25-mediated ubiquitination39
Impact of temperature on the affinity of SARS-CoV-2 Spike glycoprotein for host ACE239
Genetic lineage tracing with multiple DNA recombinases: A user's guide for conducting more precise cell fate mapping studies39
Flavonols modulate lateral root emergence by scavenging reactive oxygen species in Arabidopsis thaliana39
Autolysosomal degradation of cytosolic chromatin fragments antagonizes oxidative stress–induced senescence39
A suite of mathematical solutions to describe ternary complex formation and their application to targeted protein degradation by heterobifunctional ligands38
Evolution, expression, and substrate specificities of aldehyde oxidase enzymes in eukaryotes38
Strategies for site-specific recombination with high efficiency and precise spatiotemporal resolution38
Inhibition of the polyamine synthesis enzyme ornithine decarboxylase sensitizes triple-negative breast cancer cells to cytotoxic chemotherapy38
The testis-specific LINC component SUN3 is essential for sperm head shaping during mouse spermiogenesis38
Major tail proteins of bacteriophages of the order Caudovirales38
Functional diversity between HSP70 paralogs caused by variable interactions with specific co-chaperones38
Ferric uptake regulator (Fur) reversibly binds a [2Fe-2S] cluster to sense intracellular iron homeostasis in Escherichia coli38
Vestigial-like family member 3 (VGLL3), a cofactor for TEAD transcription factors, promotes cancer cell proliferation by activating the Hippo pathway38
Translational regulation of environmental adaptation in bacteria38
Design of a highly thermotolerant, immunogenic SARS-CoV-2 spike fragment37
Nuclear receptor phosphorylation in xenobiotic signal transduction37
The secreted protein DEL-1 activates a β3 integrin–FAK–ERK1/2–RUNX2 pathway and promotes osteogenic differentiation and bone regeneration37
A shared, stochastic pathway mediates exosome protein budding along plasma and endosome membranes37
Decoding molnupiravir-induced mutagenesis in SARS-CoV-237
A flexible network of vimentin intermediate filaments promotes migration of amoeboid cancer cells through confined environments37
Bile acid sequestration reverses liver injury and prevents progression of nonalcoholic steatohepatitis in Western diet–fed mice37
Manganese promotes α-synuclein amyloid aggregation through the induction of protein phase transition36
The biofilm adhesion protein Aap from Staphylococcus epidermidis forms zinc-dependent amyloid fibers36
Canonical Notch ligands and Fringes have distinct effects on NOTCH1 and NOTCH236
Biochemistry of nicotine metabolism and its relevance to lung cancer36
Interactions of ferritin with scavenger receptor class A members36
Structural and molecular basis for the substrate positioning mechanism of a new PL7 subfamily alginate lyase from the arctic36
Cardiac myosin contraction and mechanotransduction in health and disease36
Receptor binding, immune escape, and protein stability direct the natural selection of SARS-CoV-2 variants35
Sphingosine kills bacteria by binding to cardiolipin35
Liquid–liquid phase separation of full-length prion protein initiates conformational conversion in vitro35
Mechanisms tailoring the expression of heat shock proteins to proteostasis challenges35
Genetic diseases of the Kennedy pathways for membrane synthesis35
The short variant of optic atrophy 1 (OPA1) improves cell survival under oxidative stress35
A natural product compound inhibits coronaviral replication in vitro by binding to the conserved Nsp9 SARS-CoV-2 protein35
The therapeutic potential of inhibiting PPARγ phosphorylation to treat type 2 diabetes35
Dipeptidyl peptidase 3 modulates the renin–angiotensin system in mice35
Glycosyltransferase ST6Gal-I promotes the epithelial to mesenchymal transition in pancreatic cancer cells35
Synthetic thick filaments: A new avenue for better understanding the myosin super-relaxed state in healthy, diseased, and mavacamten-treated cardiac systems35
Emerging roles of DYRK2 in cancer35
Endosomal cAMP production broadly impacts the cellular phosphoproteome35
S-acylation of SARS-CoV-2 spike protein: Mechanistic dissection, in vitro reconstitution and role in viral infectivity35
Integrin mediates cell entry of the SARS-CoV-2 virus independent of cellular receptor ACE235
Role of long noncoding RNA MEG3/miR-378/GRB2 axis in neuronal autophagy and neurological functional impairment in ischemic stroke35
Myricetin slows liquid–liquid phase separation of Tau and activates ATG5-dependent autophagy to suppress Tau toxicity34
Circadian clock, carcinogenesis, chronochemotherapy connections34
Extended subsite profiling of the pyroptosis effector protein gasdermin D reveals a region recognized by inflammatory caspase-1134
Familial Alzheimer’s disease mutations in amyloid protein precursor alter proteolysis by γ-secretase to increase amyloid β-peptides of ≥45 residues34
The E3 ubiquitin ligase STUB1 attenuates cell senescence by promoting the ubiquitination and degradation of the core circadian regulator BMAL134
Thioredoxin regulates human mercaptopyruvate sulfurtransferase at physiologically-relevant concentrations34
DDX3X coordinates host defense against influenza virus by activating the NLRP3 inflammasome and type I interferon response34
The circadian clock shapes the Arabidopsis transcriptome by regulating alternative splicing and alternative polyadenylation34
Modulating disease-relevant tau oligomeric strains by small molecules34
MicroRNA-223-3p promotes skeletal muscle regeneration by regulating inflammation in mice34
Helicobacter pylori infection downregulates the DNA glycosylase NEIL2, resulting in increased genome damage and inflammation in gastric epithelial cells34
The structure of the extracellular domains of human interleukin 11α receptor reveals mechanisms of cytokine engagement33
The human mitochondrial 12S rRNA m4C methyltransferase METTL15 is required for mitochondrial function33
The luminescent HiBiT peptide enables selective quantitation of G protein–coupled receptor ligand engagement and internalization in living cells33
Early nucleolar responses differentiate mechanisms of cell death induced by oxaliplatin and cisplatin33
The Cdk8 kinase module regulates interaction of the mediator complex with RNA polymerase II33
High cell density increases glioblastoma cell viability under glucose deprivation via degradation of the cystine/glutamate transporter xCT (SLC7A11)33
Inflammation promotes adipocyte lipolysis via IRE1 kinase33
Dissecting the molecular determinants of clinical PARP1 inhibitor selectivity for tankyrase133
X-ray–induced photoreduction of heme metal centers rapidly induces active-site perturbations in a protein-independent manner33
NSun2 promotes cell migration through methylating autotaxin mRNA33
Intersection of the ATF6 and XBP1 ER stress pathways in mouse islet cells33
African swine fever virus cysteine protease pS273R inhibits pyroptosis by noncanonically cleaving gasdermin D33
SARS-CoV-2 (COVID-19) structural and evolutionary dynamicome: Insights into functional evolution and human genomics33
Moving beyond static snapshots: Protein dynamics and the Protein Data Bank33
The deubiquitinase USP10 restores PTEN activity and inhibits non–small cell lung cancer cell proliferation33
5′-UTR recruitment of the translation initiation factor eIF4GI or DAP5 drives cap-independent translation of a subset of human mRNAs32
Mass spectrometry characterization of light chain fragmentation sites in cardiac AL amyloidosis: insights into the timing of proteolysis32
Phosphorylation-dependent substrate selectivity of protein kinase B (AKT1)32
Acquisition of exogenous fatty acids renders apicoplast-based biosynthesis dispensable in tachyzoites of Toxoplasma32
Phosphorylation of the overlooked tyrosine 310 regulates the structure, aggregation, and microtubule- and lipid-binding properties of Tau32
Early cleavage of preimplantation embryos is regulated by tRNAGln-TTG–derived small RNAs present in mature spermatozoa32
Structure, function, and substrates of Clp AAA+ protease systems in cyanobacteria, plastids, and apicoplasts: A comparative analysis32
Wild-type sTREM2 blocks Aβ aggregation and neurotoxicity, but the Alzheimer's R47H mutant increases Aβ aggregation32
Co-targeting of CXCR4 and hedgehog pathways disrupts tumor-stromal crosstalk and improves chemotherapeutic efficacy in pancreatic cancer32
Maturation, inactivation, and recovery mechanisms of soluble guanylyl cyclase32
Structure, function, and inhibitor targeting of HIV-1 Nef-effector kinase complexes32
Suramin exposure alters cellular metabolism and mitochondrial energy production in African trypanosomes32
Sphingosine prevents binding of SARS–CoV-2 spike to its cellular receptor ACE232
Noninvasive optical detection of granzyme B from natural killer cells with enzyme-activated fluorogenic probes32
Modeling the CRL4A ligase complex to predict target protein ubiquitination induced by cereblon-recruiting PROTACs32
The transcription factor HAND2 up-regulates transcription of the IL15 gene in human endometrial stromal cells32
Resveratrol-induced Sirt1 phosphorylation by LKB1 mediates mitochondrial metabolism32
The ubiquitin system affects agronomic plant traits31
Structural and kinetic analyses of holothurian sulfated glycans suggest potential treatment for SARS-CoV-2 infection31
The RNA-binding protein PTBP1 promotes ATPase-dependent dissociation of the RNA helicase UPF1 to protect transcripts from nonsense-mediated mRNA decay31
An atomistic model of the coronavirus replication-transcription complex as a hexamer assembled around nsp1531
Dysfunctional telomeres trigger cellular senescence mediated by cyclic GMP-AMP synthase31
Hyperosmotic phase separation: Condensates beyond inclusions, granules and organelles31
The tetraspanin Tspan15 is an essential subunit of an ADAM10 scissor complex31
Cryo-electron microscopy structure of the glucagon receptor with a dual-agonist peptide31
Amino acid–derived defense metabolites from plants: A potential source to facilitate novel antimicrobial development31
Hyper-truncated Asn355- and Asn391-glycans modulate the activity of neutrophil granule myeloperoxidase31
Structure of a monomeric photosystem II core complex from a cyanobacterium acclimated to far-red light reveals the functions of chlorophylls d and f31
Interactome analysis of Caenorhabditis elegans synapses by TurboID-based proximity labeling31
Inhibition of glycosphingolipid biosynthesis reverts multidrug resistance by differentially modulating ABC transporters in chronic myeloid leukemias31
Post-translational control of the long and winding road to cholesterol31
Human ribosomal G-quadruplexes regulate heme bioavailability31
Cotranslational folding stimulates programmed ribosomal frameshifting in the alphavirus structural polyprotein31
Structural basis of the interplay between α-synuclein and Tau in regulating pathological amyloid aggregation31
Is γ-secretase a beneficial inactivating enzyme of the toxic APP C-terminal fragment C99?31
Protein interaction networks in neurodegenerative diseases: From physiological function to aggregation31
Structural features of the protein kinase domain and targeted binding by small-molecule inhibitors31
Prevalence and species distribution of the low-complexity, amyloid-like, reversible, kinked segment structural motif in amyloid-like fibrils31
MtcB, a member of the MttB superfamily from the human gut acetogen Eubacterium limosum, is a cobalamin-dependent carnitine demethylase31