Journal of Biological Chemistry

(The H4-Index of Journal of Biological Chemistry is 62. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-04-01 to 2024-04-01.)
Remdesivir is a direct-acting antiviral that inhibits RNA-dependent RNA polymerase from severe acute respiratory syndrome coronavirus 2 with high potency704
The antiviral compound remdesivir potently inhibits RNA-dependent RNA polymerase from Middle East respiratory syndrome coronavirus577
The molecular virology of coronaviruses357
Mechanisms of evolved herbicide resistance318
SARS-CoV-2 infects cells after viral entry via clathrin-mediated endocytosis303
Ethylene signaling in plants284
Inhibition of SARS–CoV-2 by type I and type III interferons207
The SARS-CoV-2 envelope and membrane proteins modulate maturation and retention of the spike protein, allowing assembly of virus-like particles201
Molnupiravir promotes SARS-CoV-2 mutagenesis via the RNA template195
Oxygen battle in the gut: Hypoxia and hypoxia-inducible factors in metabolic and inflammatory responses in the intestine173
Biosynthesis of the modified tetrapyrroles—the pigments of life164
Brain manganese and the balance between essential roles and neurotoxicity164
Antisense technology: A review150
Structural and functional conservation of the programmed −1 ribosomal frameshift signal of SARS coronavirus 2 (SARS-CoV-2)144
Impaired NLRP3 inflammasome activation/pyroptosis leads to robust inflammatory cell death via caspase-8/RIPK3 during coronavirus infection138
The essential elements of Alzheimer’s disease136
Zinc transporters and their functional integration in mammalian cells123
Recent advances in de novo protein design: Principles, methods, and applications119
Major advances in targeted protein degradation: PROTACs, LYTACs, and MADTACs118
Coronavirus infection and PARP expression dysregulate the NAD metabolome: An actionable component of innate immunity117
Post-translational modifications of Hsp90 and translating the chaperone code116
Template-dependent inhibition of coronavirus RNA-dependent RNA polymerase by remdesivir reveals a second mechanism of action115
Post-translational modifications of Hsp70 family proteins: Expanding the chaperone code102
The emerging role of α-synuclein truncation in aggregation and disease99
Mechanisms of adhesion G protein–coupled receptor activation99
The interplay of fibroblasts, the extracellular matrix, and inflammation in scar formation98
The Zα2 domain of ZBP1 is a molecular switch regulating influenza-induced PANoptosis and perinatal lethality during development95
The chaperone GRP78 is a host auxiliary factor for SARS-CoV-2 and GRP78 depleting antibody blocks viral entry and infection95
Disassembly of Tau fibrils by the human Hsp70 disaggregation machinery generates small seeding-competent species93
Unusual zwitterionic catalytic site of SARS–CoV-2 main protease revealed by neutron crystallography93
ZBP1 promotes fungi-induced inflammasome activation and pyroptosis, apoptosis, and necroptosis (PANoptosis)92
Lipopolysaccharide O-antigens—bacterial glycans made to measure91
Mitochondrial metabolism regulates macrophage biology90
CRISPR-Cas12a has widespread off-target and dsDNA-nicking effects88
N6-Methyladenosine modification of hepatitis B and C viral RNAs attenuates host innate immunity via RIG-I signaling87
Role of the lipid bilayer in outer membrane protein folding in Gram-negative bacteria87
The 89-kDa PARP1 cleavage fragment serves as a cytoplasmic PAR carrier to induce AIF-mediated apoptosis86
Piezo1 acts upstream of TRPV4 to induce pathological changes in endothelial cells due to shear stress85
The SARS-CoV-2 Y453F mink variant displays a pronounced increase in ACE-2 affinity but does not challenge antibody neutralization85
Structural basis for the in vitro efficacy of nirmatrelvir against SARS-CoV-2 variants85
1,6-Hexanediol, commonly used to dissolve liquid–liquid phase separated condensates, directly impairs kinase and phosphatase activities83
A molecular roadmap to the plant immune system83
The importance of thiamine (vitamin B1) in plant health: From crop yield to biofortification81
Zinc promotes liquid–liquid phase separation of tau protein81
Discovery of amivantamab (JNJ-61186372), a bispecific antibody targeting EGFR and MET80
Raffinose synthase enhances drought tolerance through raffinose synthesis or galactinol hydrolysis in maize and Arabidopsis plants79
SARS-CoV-2 viral budding and entry can be modeled using BSL-2 level virus-like particles77
High affinity binding of SARS-CoV-2 spike protein enhances ACE2 carboxypeptidase activity73
Toward the solution of the protein structure prediction problem72
From OCR and ECAR to energy: Perspectives on the design and interpretation of bioenergetics studies71
Small molecule strategies to harness the unfolded protein response: where do we go from here?70
The spike protein of SARS-CoV-2 induces endothelial inflammation through integrin α5β1 and NF-κB signaling70
Deubiquitinating enzymes (DUBs): Regulation, homeostasis, and oxidative stress response68
Acidity and nucleophilic reactivity of glutathione persulfide68
Seeing beyond the limit: A guide to choosing the right super-resolution microscopy technique68
Presence of hyaluronan in lung alveoli in severe Covid-19: An opening for new treatment options?67
Role of host factors in SARS-CoV-2 entry67
Exploring cellular biochemistry with nanobodies65
The mitochondria-targeted peptide SS-31 binds lipid bilayers and modulates surface electrostatics as a key component of its mechanism of action64
Targeting mitophagy in Parkinson's disease63
Bacterial iron detoxification at the molecular level63
Iron homeostasis and plant immune responses: Recent insights and translational implications62
Inhibition of acid sphingomyelinase by ambroxol prevents SARS-CoV-2 entry into epithelial cells62