Immunology

Article	Citations
Editorial: Highlighting early‐career researchers—The future of Immunology	376
Featured Cover	126
New Engineered‐Chimeric Botulinum Neurotoxin Mutant Acts as an Effective Bivalent Vaccine Against Botulinum Neurotoxin Serotype A and E	81
Maternal Carriage of Prevotella copri Is Associated With Increased Thymus Derived Naïve Regulatory T Cells in Cord Blood	80
Effectiveness of interleukin‐4 administration or zinc supplementation in improving zinc deficiency–associated thymic atrophy and fatty degeneration and in normalizing T cell maturation process	77
High common‐γ cytokine receptor levels promote expression of Interleukin‐2/Interleukin‐7 receptor α‐chains with implications on T‐cell differentiation and function	71
Interferon‐α promotes MHC I antigen presentation of islet β cells through STAT1‐IRF7 pathway in type 1 diabetes	66
The immune response to COVID‐19: Does sex matter?	62
The role of high‐density lipoprotein in the regulation of the immune response: implications for atherosclerosis and autoimmunity	60
The hippo kinase MST1 negatively regulates the differentiation of follicular helper T cells	58
Conditional knockout of oestrogen receptor alpha in CD11c+ cells impacts female survival and inflammatory cytokine profile in murine lupus	56
Update on the current knowledge of lymphatic drainage system and its emerging roles in glioma management	54
Hypoxic tumour‐derived exosomal miR‐1290 exacerbates the suppression of CD8+ T cells by promoting M2 macrophage polarization	54
A new strategy for immunotherapy of microsatellite‐stable (MSS)‐type advanced colorectal cancer: Multi‐pathway combination therapy with PD‐1/PD‐L1 inhibitors	52
What's in a name? Nomenclature in immunology	49
Issue Information	48
CD11c participates in triggering acute graft‐versus‐host disease during bone marrow transplantation	47
Issue Information	44
DNA methylation trajectories during innate and adaptive immune responses of human B lymphocytes	43
Identification of psoriasis‐associated immune marker G3BP2 through single‐cell RNA sequencing and meta analysis	43
Distinct responses of human peripheral blood cells to different misfolded protein oligomers	42
Trispecific antibodies for cancer immunotherapy	40
Immunogenicity and safety of SpikoGen®, an adjuvanted recombinant SARS‐CoV‐2 spike protein vaccine as a homologous and heterologous booster vaccination: A randomized placebo‐controlled trial	39
Dynamics of T follicular helper cells in patients with rheumatic diseases and subsequent antibody responses in a three‐dose immunization regimen of CoronaVac	38
Idiotopes of antibodies against HIV‐1 CD4‐induced epitope shared with those against microorganisms	38

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Identification of different functions of CD8+ T cell subpopulations by a novel monoclonal antibody	33
Embedding of exogenous B cell epitopes on the surface of UreB structure generates a broadly reactive antibody response against Helicobacter pylori	31
Prognostic biomarkers associated with immune checkpoint inhibitors in hepatocellular carcinoma	31
A detective story of intermittent fasting effect on immunity	29
Caspase‐6 is a key regulator of cross‐talk signal way in PANoptosis in cancer	29
New‐onset autoimmune phenomena post‐COVID‐19 vaccination	29
T cell maturation is significantly affected by SARS‐CoV‐2 infection	29
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Issue Information	28
Antibodies to SARS‐CoV‐2 in patients with primary immunodeficiencies treated with nonspecific immunoglobulins	27
Correlation between antibodies against the pathogenic pHERV‐W envelope protein and the inflammatory phase of multiple sclerosis	27
Dietary human milk oligosaccharides reduce allergic airway inflammation by modulating SCFAs level and ILC2 activity	26
The alterations of innate immunity and enhanced severity of infections in diabetes mellitus	26
Expression of RAG and secondary gene rearrangement of BCR in mature peripheral B lymphocytes in Takayasu arteritis	25
Corrigendum	25
Early life vaccination reprograms the metabolism and function of myeloid cells in neonates	24
Assessment of IgG‐Fc glycosylation from individual RhD‐specific B cell clones reveals regulation at clonal rather than clonotypic level	24
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Pneumolysin suppresses the initial macrophage pro‐inflammatory response to Streptococcus pneumoniae	23
Crosstalk between B cells and neutrophils in rheumatoid arthritis	23
Memory CD8+ T cells exhibit tissue imprinting and non‐stable exposure‐dependent reactivation characteristics following blood‐stage Plasmodium berghei ANKA infections	23
Peripheral blood MR1 tetramer‐positive mucosal‐associated invariant T‐cell function is modulated by mammalian target of rapamycin complex 1 in patients with active tuberculosis	22
Mucosal‐associated invariant T cells in digestive tract: Local guardians or destroyers?	22
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Integration of Immune Responses and Transcriptomic Signatures Reveals the Efficacy of Maternal Genetic Vaccination in a Pregnant Model and Its Neonates	20
Issue Information	20
Macrophage metabolism in the intestine is compartment specific and regulated by the microbiota	20
CD226 deficiency exacerbated intestinal immune dysregulation in mice with dinitrochlorobenzene‐induced atopic dermatitis	20
TLR9 activation is required for cytotoxic response elicited by baculovirus capsid display	20
Eosinophil plays a crucial role in intestinal mucositis induced by antineoplastic chemotherapy	20
Dysregulation of B lymphocyte development in the SKG mouse model of rheumatoid arthritis	19
Helios—Illuminating the way for lymphocyte self‐control	19
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6‐Mercaptopurine potently inhibits recruitment of SHP2 by phosphorylated PD‐1 to inhibit PD‐1 signalling and enhance T cell function	19
Towards understanding the role of nanomedicine in targeting TNFR2 in rheumatoid arthritis	18
Diagnostic Significance of Metagenomic Next‐Generation Sequencing in Immunocompromised Patients With Suspected Pulmonary Infection	18
A Novel Polymersome Nanocarrier Promotes Anti‐Tumour Immunity by Improved Priming of CD8+ T Cells	18
Lineage Tracking Dissects the Fate of Neonatal iNKT Cells Later in Life	18
Dysregulated neutrophil extracellular traps formation in sepsis	17
Unravelling the Impact of Outer Membrane Protein, OmpA, From S. Typhimurium on Aberrant AID Expression and IgM to IgA Class Switching in H	17
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Vascular and immunopathological role of Asymmetric Dimethylarginine (ADMA) in Experimental Autoimmune Encephalomyelitis	17
The soluble IL‐2 receptor α/CD25 as a modulator of IL‐2 function	17
Antibody‐dependent cell‐mediated cytotoxicity using T cells with NK‐like phenotype in combination with avelumab, an anti‐PD‐L1 antibody	17
Activation‐induced marker assays for identification of Trypanosoma cruzi‐specific CD4 or CD8 T cells in chronic Chagas disease patients	17
Exploration of the efficacy of anti‐immunoglobulin E monoclonal antibodies in the treatment of allergic asthma	17
Issue Information	17
Ceftazidime reduces cellular Skp2 to promote type‐I interferon activity	16

Helper innate lymphoid cells as cell therapy for cancer	16
Distinct antigen uptake receptors route to the same storage compartments for cross‐presentation in dendritic cells	16
Paleo‐immunology of human anti‐carbohydrate antibodies preventing primate extinctions	16
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An immunogenetic investigation of 30 autoimmune and autoinflammatory diseases and their links to psychiatric disorders in a nationwide sample	16
Simultaneous Blockade of CD209 and CD209L by Monoclonal Antibody Does Not Provide Sufficient Protection Against Multiple Viral Infections In Vivo	15
Pla2g5 contributes to viral‐like‐induced lung inflammation through macrophage proliferation and LA/Ffar1 lung cell recruitment	15
Optimization of Immunotherapy Strategies Based on Spatiotemporal Heterogeneity of Tumour‐Associated Tissue‐Resident Memory T Cells	15
Augmenting Macrophages Apoptosis Induced by Carnitine Palmitoyl Transferase 1A Inhibition via Acetyl‐CoA‐Associated Protein Acetylation	15
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IL‐20 is involved in obesity by modulation of adipogenesis and macrophage dysregulation	15
Distinguishing activated T regulatory cell and T conventional cells by single‐cell technologies	15
Neutralizing interferon‐α blocks inflammation‐mediated vascular injury via PI3K and AMPK in systemic lupus erythematosus	15
Sphingosine‐1‐Phosphate Signalling Inhibition Suppresses Th1‐Like Treg Generation by Reversing Mitochondrial Uncoupling	14
Issue Information	14
Issue Information	14
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Tumour‐associated neutrophils: Potential therapeutic targets in pancreatic cancer immunotherapy	13
Immune control of Mycobacterium tuberculosis is dependent on both soluble TNFRp55 and soluble TNFRp75	13
Cooperative induction of CXCL chemokines by inflammatory cytokines and oxidized phospholipids	13
cAMP responsive element modulator α promotes effector T cells in systemic autoimmune diseases	13
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Splenocytes with fucosylation deficiency promote T cell proliferation and differentiation through thrombospondin‐1 downregulation	13
Omicron breakthrough infections after triple‐dose inactivated COVID‐19 vaccination: A comprehensive analysis of antibody and T‐cell responses	13
Epigenetics: An opportunity to shape innate and adaptive immune responses	13
IL‐10 indirectly modulates functional activity of CD4+CD28null T‐lymphocytes through LFA‐3 and HLA class II inhi	12
Intramacrophage lipid accumulation compromises T cell responses and is associated with impaired drug therapy against visceral leishmaniasis	12
CD5L attenuates allergic airway inflammation by expanding CD11chigh alveolar macrophages and inhibiting NLRP3 inflammasome activation via HDAC2	12
Autoantigen‐selected B cells are bystanders in spontaneous T cell‐driven experimental autoimmune hepatitis	12
Preclinical stage abundance and nuclear antigen reactivity of faecal Immunoglobulin A vary among males and females of lupus‐prone mouse models	12
IBD functions as a double‐edged sword for food allergy in BALB/c mice model	12
The clinical relevance of epithelial‐mesenchymal transition and its correlations with tumorigenic immune infiltrates in hepatocellular carcinoma	12
Sequential engagement of adhesion molecules and cytokine receptors impacts both piecemeal and anaphylactic degranulation of human basophils	12
Epstein–Barr Virus‐Induced 3 Attributes to TLR7‐Mediated Splenomegaly	11
IL‐1β promotes IL‐17A production of ILC3s to aggravate neutrophilic airway inflammation in mice	11
Polygenic TB control and the sequence of innate/adaptive immune responses to infection: MHC‐II alleles determine the size of the S100A8/9‐producing neutroph	11
K33 only mutant ubiquitin augments bone marrow‐derived dendritic cell‐mediated CTL priming via PI3K‐Akt pathway	11
NRP1 downregulation correlates with enhanced ILC2 responses during IL‐33 challenge	11
The Neurobeachin‐like 2 protein (NBEAL2) controls the homeostatic level of the ribosomal protein RPS6 in mast cells	11
Ectopic endometriotic stromal cells‐derived lactate induces M2 macrophage polarization via Mettl3/Trib1/ERK/STAT3 signalling pathway in endometriosis	11
mTORC2 contributes to systemic autoimmunity	11
Editorial: Perspectives on the landscape of immunology from Nikhil Joshi	11
TIM3/CEACAM1 pathway involves in myeloid‐derived suppressor cells induced CD8+ T cells exhaustion and bone marrow inflammatory microenvironment in myelodysp	11
Biological functions of IL‐17‐producing cells in mycoplasma respiratory infection	11
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Myeloid‐derived suppressor cells from tumour‐bearing mice induce the population expansion of CD19hiFcγRIIbhi regulatory B cells via PD‐L1	11
Retinal microglia: Functions and diseases	10
LncRNA00492 is required for marginal zone B‐cell development	10
Lung adenocarcinoma manifesting as subsolid nodule potentially represents tumour in the equilibrium phase of immunoediting	10
Staphylococcus aureus biofilm properties and chronic rhinosinusitis severity scores correlate positively with total CD4+ T‐cell frequencies and inversely with its Th1, Th1	10
Alternative pathway dysregulation in tissues drives sustained complement activation and predicts outcome across the disease course in COVID‐19	10
Mast cells contribute to T‐cell accumulation in the bronchoalveolar space in mice with IL‐33‐induced airway inflammation	9
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Adoptive transfer of IL‐4 reprogrammed Tc17 cells elicits anti‐tumour immunity through functional plasticity	9
Chimerism of avian IgY‐scFv and truncated IgG‐Fc: A novel strategy in cross‐species antibody generation and enhancement	9
Issue Information	9
Deciphering the IgG Idiotype Network Through Proteomic Analysis of Potential Targets in SARS‐CoV‐2‐Induced Immune Responses	9
Correction to “Psychological stress to ovalbumin peptide‐specific T‐cell receptor transgenic mice impairs the suppressive ability of type 1 regulatory T cell”	9
Issue Information	9
Age‐related changes in ocular mucosal tolerance: Lessons learned from gut and respiratory tract immunity	9
TREM1/DAP12 based novel multiple chain CAR‐T cells targeting DLL3 show robust anti‐tumour efficacy for small cell lung cancer	9
Role of airway epithelium in viral respiratory infections: Can carbocysteine prevent or mitigate them?	9
IL‐6 Signalling to Responding T Cells Is Key to Calcitonin Gene‐Related Peptide‐Exposed Endothelial Cell Enhancement of Th17 Immunity During Langerhans Cell Antigen Presentation	9
Mycobacterium potentiates protection from colorectal cancer by gut microbial alterations	9
Induction of a cytokine storm involves suppression of the Osteopontin‐dependent TH1 response	9
Vaccines, adjuvants and key factors for mucosal immune response	9
Distinct contributions of the innate immune receptors TLR2 and RP105 to formation and architecture of structured lung granulomas in mice infected with Mycobacterium tuberculos	9
Fc Fragment of IgE Receptor Ig (FCER1G) acts as a key gene involved in cancer immune infiltration and tumour microenvironment	8
Dual effect of IL‐7/IL‐7R signalling on the osteoimmunological system: a potential therapeutic target for rheumatoid arthritis	8
The role of HMGB1 in COVID‐19‐induced cytokine storm and its potential therapeutic targets: A review	8
Systemic and mucosal mobilization of granulocyte subsets during lentiviral infection	8
CD5L is upregulated upon infection with Mycobacterium tuberculosis with no effect on disease progression	8
PD‐1 expression on tumour‐infiltrating cells is a prognostic factor for relapsed or refractory diffuse large B‐cell lymphoma	8
βhCG mediates immune suppression through upregulation of CD11b+Gr1+ myeloid derived suppressor cells, CD206+M2 macrophages,	8
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Pellino3 ligase negatively regulates influenza B dependent RIG‐I signalling through downregulation of TRAF3‐mediated induction of the transcription factor IRF3 and	8
Neutrophils in secondary lymphoid organs	8
Engineered polyspecific antibodies: A new frontier in the field of immunotherapeutics	8
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Transcriptomic landscape of skin lesions in cutaneous leishmaniasis reveals a strong CD8+ T cell immunosenescence signature linked to immunopathology	8

Role of CD14 in human disease	8
Activating receptor KIR2DS2 bound to HLA‐C1 reveals the novel recognition features of activating receptor	8
Circadian rhythm regulation in the immune system	8
Critical roles of the E3 ubiquitin ligase FBW7 in B‐cell response and the pathogenesis of experimental autoimmune arthritis	8
Issue Information	8
Endocannabinoids in immune regulation and immunopathologies	7
A robust platform for integrative spatial multi‐omics analysis to map immune responses to SARS‐CoV‐2 infection in lung tissues	7
Downregulation of type I interferon signalling pathway by urate in primary human PBMCs	7
SNX17 Regulates Antigen Internalisation and Phagosomal Maturation by Dendritic Cells	7
Blocking T‐cell egress with FTY720 extends DNA vaccine expression but reduces immunogenicity	7
Impact of sex differences on the clinical presentation, pathogenesis, treatment and prognosis of Sjögren's syndrome	7
BCG‐mediated protection against M. tuberculosis is sustained post‐malaria infection independent of parasite virulence	7
How maternal factors shape the immune system of breastfed infants to alleviate food allergy: A systematic and updated review	7
The functional diversity of tissue‐resident natural killer cells against infection	7
Interleukin‐35 is a critical regulator of immunity during helminth infections associated with multiple sclerosis	7
Coexistence of IL12Rβ1 and BTK Mutations in a Family	7
Peritoneal GATA6+ macrophage drives hepatic immunopathogenesis and maintains the Treg cell niche in the liver	7
Complement: Functions, location and implications	7
NR4A1 mediates NK‐cell dysfunction in hepatocellular carcinoma via the IFN‐γ/p‐STAT1/IRF1 pathway	7
Clinical C3 Inhibition With AMY‐101 Reveals Novel Insights Into IL‐8‐Driven Inflammation in COVID‐19	7
Identification of neoantigens in oesophageal adenocarcinoma	7
CD39 pathway inhibits Th1 cell function in tuberculosis	7
Regulatory B cells protect against chronic hypoxia‐induced pulmonary hypertension by modulating the Tfh/Tfr immune balance	7