Immunology

Article	Citations
Editorial: Highlighting early‐career researchers—The future of Immunology	390
Featured Cover	139
New Engineered‐Chimeric Botulinum Neurotoxin Mutant Acts as an Effective Bivalent Vaccine Against Botulinum Neurotoxin Serotype A and E	91
Effectiveness of interleukin‐4 administration or zinc supplementation in improving zinc deficiency–associated thymic atrophy and fatty degeneration and in normalizing T cell maturation process	89
Interferon‐α promotes MHC I antigen presentation of islet β cells through STAT1‐IRF7 pathway in type 1 diabetes	81
Issue Information	79
High common‐γ cytokine receptor levels promote expression of Interleukin‐2/Interleukin‐7 receptor α‐chains with implications on T‐cell differentiation and function	78
The immune response to COVID‐19: Does sex matter?	73
Update on the current knowledge of lymphatic drainage system and its emerging roles in glioma management	66
Maternal Carriage of Prevotella copri Is Associated With Increased Thymus Derived Naïve Regulatory T Cells in Cord Blood	60
The hippo kinase MST1 negatively regulates the differentiation of follicular helper T cells	60
Conditional knockout of oestrogen receptor alpha in CD11c+ cells impacts female survival and inflammatory cytokine profile in murine lupus	59
Hypoxic tumour‐derived exosomal miR‐1290 exacerbates the suppression of CD8+ T cells by promoting M2 macrophage polarization	58
A new strategy for immunotherapy of microsatellite‐stable (MSS)‐type advanced colorectal cancer: Multi‐pathway combination therapy with PD‐1/PD‐L1 inhibitors	57
What's in a name? Nomenclature in immunology	53
Issue Information	50
Issue Information	47
Dynamics of T follicular helper cells in patients with rheumatic diseases and subsequent antibody responses in a three‐dose immunization regimen of CoronaVac	46
DNA methylation trajectories during innate and adaptive immune responses of human B lymphocytes	42
Immunogenicity and safety of SpikoGen®, an adjuvanted recombinant SARS‐CoV‐2 spike protein vaccine as a homologous and heterologous booster vaccination: A randomized placebo‐controlled trial	39
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Identification of different functions of CD8+ T cell subpopulations by a novel monoclonal antibody	36
Identification of psoriasis‐associated immune marker G3BP2 through single‐cell RNA sequencing and meta analysis	32
Prognostic biomarkers associated with immune checkpoint inhibitors in hepatocellular carcinoma	32
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Embedding of exogenous B cell epitopes on the surface of UreB structure generates a broadly reactive antibody response against Helicobacter pylori	31
Idiotopes of antibodies against HIV‐1 CD4‐induced epitope shared with those against microorganisms	31
Trispecific antibodies for cancer immunotherapy	31
Caspase‐6 is a key regulator of cross‐talk signal way in PANoptosis in cancer	30
New‐onset autoimmune phenomena post‐COVID‐19 vaccination	30
Immunomodulatory Mechanisms of ILC2 in Lung Development: Emerging Insights Into Bronchopulmonary Dysplasia Pathogenesis	29
Issue Information	29
Assessment of IgG‐Fc glycosylation from individual RhD‐specific B cell clones reveals regulation at clonal rather than clonotypic level	29
Correlation between antibodies against the pathogenic pHERV‐W envelope protein and the inflammatory phase of multiple sclerosis	27
Expression of RAG and secondary gene rearrangement of BCR in mature peripheral B lymphocytes in Takayasu arteritis	27
T cell maturation is significantly affected by SARS‐CoV‐2 infection	26
Memory CD8+ T cells exhibit tissue imprinting and non‐stable exposure‐dependent reactivation characteristics following blood‐stage Plasmodium berghei ANKA infections	26
Antibodies to SARS‐CoV‐2 in patients with primary immunodeficiencies treated with nonspecific immunoglobulins	25
Corrigendum	25
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Early life vaccination reprograms the metabolism and function of myeloid cells in neonates	24
CCR5‐Mediated Reprogramming of Regulatory T Cells and Monocytic‐Myeloid‐Derived Suppressor Cells in Young Dyslipidemic Individuals: A Plausible Therapeutic Approach	23
A detective story of intermittent fasting effect on immunity	22
Induction of Regulatory T Cells After Virus Infection and Vaccination	22
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The alterations of innate immunity and enhanced severity of infections in diabetes mellitus	22
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Dietary human milk oligosaccharides reduce allergic airway inflammation by modulating SCFAs level and ILC2 activity	22
Helios—Illuminating the way for lymphocyte self‐control	21
Integration of Immune Responses and Transcriptomic Signatures Reveals the Efficacy of Maternal Genetic Vaccination in a Pregnant Model and Its Neonates	21
Dysregulated neutrophil extracellular traps formation in sepsis	21
Diagnostic Significance of Metagenomic Next‐Generation Sequencing in Immunocompromised Patients With Suspected Pulmonary Infection	21
The soluble IL‐2 receptor α/CD25 as a modulator of IL‐2 function	21
CD226 deficiency exacerbated intestinal immune dysregulation in mice with dinitrochlorobenzene‐induced atopic dermatitis	20
A Novel Polymersome Nanocarrier Promotes Anti‐Tumour Immunity by Improved Priming of CD8+ T Cells	20
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Macrophage metabolism in the intestine is compartment specific and regulated by the microbiota	19
Activation‐induced marker assays for identification of Trypanosoma cruzi‐specific CD4 or CD8 T cells in chronic Chagas disease patients	19
Lineage Tracking Dissects the Fate of Neonatal iNKT Cells Later in Life	19
TLR9 activation is required for cytotoxic response elicited by baculovirus capsid display	19
Mucosal‐associated invariant T cells in digestive tract: Local guardians or destroyers?	19
Eosinophil plays a crucial role in intestinal mucositis induced by antineoplastic chemotherapy	19
Peripheral blood MR1 tetramer‐positive mucosal‐associated invariant T‐cell function is modulated by mammalian target of rapamycin complex 1 in patients with active tuberculosis	18
Towards understanding the role of nanomedicine in targeting TNFR2 in rheumatoid arthritis	18
6‐Mercaptopurine potently inhibits recruitment of SHP2 by phosphorylated PD‐1 to inhibit PD‐1 signalling and enhance T cell function	18
Pneumolysin suppresses the initial macrophage pro‐inflammatory response to Streptococcus pneumoniae	18
Dysregulation of B lymphocyte development in the SKG mouse model of rheumatoid arthritis	18
Crosstalk between B cells and neutrophils in rheumatoid arthritis	17
Vascular and immunopathological role of Asymmetric Dimethylarginine (ADMA) in Experimental Autoimmune Encephalomyelitis	17
Issue Information	17
Unravelling the Impact of Outer Membrane Protein, OmpA, From S. Typhimurium on Aberrant AID Expression and IgM to IgA Class Switching in H	17
γδT Cells in IBD: Beneficial or Detrimental?	17
Ceftazidime reduces cellular Skp2 to promote type‐I interferon activity	16
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IL‐20 is involved in obesity by modulation of adipogenesis and macrophage dysregulation	16
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Optimization of Immunotherapy Strategies Based on Spatiotemporal Heterogeneity of Tumour‐Associated Tissue‐Resident Memory T Cells	15
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Pla2g5 contributes to viral‐like‐induced lung inflammation through macrophage proliferation and LA/Ffar1 lung cell recruitment	15
Distinguishing activated T regulatory cell and T conventional cells by single‐cell technologies	15
Helper innate lymphoid cells as cell therapy for cancer	14
Antibody‐dependent cell‐mediated cytotoxicity using T cells with NK‐like phenotype in combination with avelumab, an anti‐PD‐L1 antibody	14
The Roles of T Cells in the Development of Metabolic Dysfunction‐Associated Steatohepatitis	14
An immunogenetic investigation of 30 autoimmune and autoinflammatory diseases and their links to psychiatric disorders in a nationwide sample	14
Issue Information	14
Exploration of the efficacy of anti‐immunoglobulin E monoclonal antibodies in the treatment of allergic asthma	14
Paleo‐immunology of human anti‐carbohydrate antibodies preventing primate extinctions	14
Sphingosine‐1‐Phosphate Signalling Inhibition Suppresses Th1‐Like Treg Generation by Reversing Mitochondrial Uncoupling	13
Issue Information	13
Augmenting Macrophages Apoptosis Induced by Carnitine Palmitoyl Transferase 1A Inhibition via Acetyl‐CoA‐Associated Protein Acetylation	13
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Splenocytes with fucosylation deficiency promote T cell proliferation and differentiation through thrombospondin‐1 downregulation	12
IBD functions as a double‐edged sword for food allergy in BALB/c mice model	12
CD5L attenuates allergic airway inflammation by expanding CD11chigh alveolar macrophages and inhibiting NLRP3 inflammasome activation via HDAC2	12
Preclinical stage abundance and nuclear antigen reactivity of faecal Immunoglobulin A vary among males and females of lupus‐prone mouse models	12
cAMP responsive element modulator α promotes effector T cells in systemic autoimmune diseases	12
The Neurobeachin‐like 2 protein (NBEAL2) controls the homeostatic level of the ribosomal protein RPS6 in mast cells	12
Cooperative induction of CXCL chemokines by inflammatory cytokines and oxidized phospholipids	12
Sequential engagement of adhesion molecules and cytokine receptors impacts both piecemeal and anaphylactic degranulation of human basophils	12
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Intramacrophage lipid accumulation compromises T cell responses and is associated with impaired drug therapy against visceral leishmaniasis	12
Ectopic endometriotic stromal cells‐derived lactate induces M2 macrophage polarization via Mettl3/Trib1/ERK/STAT3 signalling pathway in endometriosis	11
IL‐10 indirectly modulates functional activity of CD4+CD28null T‐lymphocytes through LFA‐3 and HLA class II inhi	11
Epstein–Barr Virus‐Induced 3 Attributes to TLR7‐Mediated Splenomegaly	11
The clinical relevance of epithelial‐mesenchymal transition and its correlations with tumorigenic immune infiltrates in hepatocellular carcinoma	11
Epigenetics: An opportunity to shape innate and adaptive immune responses	11
Tumour‐associated neutrophils: Potential therapeutic targets in pancreatic cancer immunotherapy	11
Omicron breakthrough infections after triple‐dose inactivated COVID‐19 vaccination: A comprehensive analysis of antibody and T‐cell responses	11
TIM3/CEACAM1 pathway involves in myeloid‐derived suppressor cells induced CD8+ T cells exhaustion and bone marrow inflammatory microenvironment in myelodysp	11
Polygenic TB control and the sequence of innate/adaptive immune responses to infection: MHC‐II alleles determine the size of the S100A8/9‐producing neutroph	11
Autoantigen‐selected B cells are bystanders in spontaneous T cell‐driven experimental autoimmune hepatitis	11
Simultaneous Blockade of CD209 and CD209L by Monoclonal Antibody Does Not Provide Sufficient Protection Against Multiple Viral Infections In Vivo	11
IL‐1β promotes IL‐17A production of ILC3s to aggravate neutrophilic airway inflammation in mice	11
Staphylococcus aureus biofilm properties and chronic rhinosinusitis severity scores correlate positively with total CD4+ T‐cell frequencies and inversely with its Th1, Th1	10
K33 only mutant ubiquitin augments bone marrow‐derived dendritic cell‐mediated CTL priming via PI3K‐Akt pathway	10
Myeloid‐derived suppressor cells from tumour‐bearing mice induce the population expansion of CD19hiFcγRIIbhi regulatory B cells via PD‐L1	10
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mTORC2 contributes to systemic autoimmunity	10
NRP1 downregulation correlates with enhanced ILC2 responses during IL‐33 challenge	10
Chimerism of avian IgY‐scFv and truncated IgG‐Fc: A novel strategy in cross‐species antibody generation and enhancement	10
Lung adenocarcinoma manifesting as subsolid nodule potentially represents tumour in the equilibrium phase of immunoediting	10
Editorial: Perspectives on the landscape of immunology from Nikhil Joshi	10
Alternative pathway dysregulation in tissues drives sustained complement activation and predicts outcome across the disease course in COVID‐19	10
LncRNA00492 is required for marginal zone B‐cell development	10
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TREM1/DAP12 based novel multiple chain CAR‐T cells targeting DLL3 show robust anti‐tumour efficacy for small cell lung cancer	9
Fc Fragment of IgE Receptor Ig (FCER1G) acts as a key gene involved in cancer immune infiltration and tumour microenvironment	9
Adoptive transfer of IL‐4 reprogrammed Tc17 cells elicits anti‐tumour immunity through functional plasticity	9
Activating receptor KIR2DS2 bound to HLA‐C1 reveals the novel recognition features of activating receptor	9
Deciphering the IgG Idiotype Network Through Proteomic Analysis of Potential Targets in SARS‐CoV‐2‐Induced Immune Responses	9
Role of airway epithelium in viral respiratory infections: Can carbocysteine prevent or mitigate them?	9
Issue Information	9
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Mast cells contribute to T‐cell accumulation in the bronchoalveolar space in mice with IL‐33‐induced airway inflammation	9
βhCG mediates immune suppression through upregulation of CD11b+Gr1+ myeloid derived suppressor cells, CD206+M2 macrophages,	9
Distinct contributions of the innate immune receptors TLR2 and RP105 to formation and architecture of structured lung granulomas in mice infected with Mycobacterium tuberculos	9
The Contribution of Complement System in Multiple Sclerosis: Mechanisms and Therapeutic Potentials	9
Retinal microglia: Functions and diseases	9
CD73 Expression by CD4+ T Cells Marks Early Effector Memory T Cells	9
Correction to “Psychological stress to ovalbumin peptide‐specific T‐cell receptor transgenic mice impairs the suppressive ability of type 1 regulatory T cell”	9
Mycobacterium potentiates protection from colorectal cancer by gut microbial alterations	9
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The role of HMGB1 in COVID‐19‐induced cytokine storm and its potential therapeutic targets: A review	9
Induction of a cytokine storm involves suppression of the Osteopontin‐dependent TH1 response	9
IL‐6 Signalling to Responding T Cells Is Key to Calcitonin Gene‐Related Peptide‐Exposed Endothelial Cell Enhancement of Th17 Immunity During Langerhans Cell Antigen Presentation	9
Vaccines, adjuvants and key factors for mucosal immune response	9
Acute Plasmodium yoelii17XNL Infection During BCG Vaccination Limits T Cell Responses and Mycobacterial Growth Inhibition	9
Blocking T‐cell egress with FTY720 extends DNA vaccine expression but reduces immunogenicity	8
Identification of neoantigens in oesophageal adenocarcinoma	8
Role of CD14 in human disease	8
Circadian rhythm regulation in the immune system	8
CD39 pathway inhibits Th1 cell function in tuberculosis	8
Complement: Functions, location and implications	8
A robust platform for integrative spatial multi‐omics analysis to map immune responses to SARS‐CoV‐2 infection in lung tissues	8

PD‐1 expression on tumour‐infiltrating cells is a prognostic factor for relapsed or refractory diffuse large B‐cell lymphoma	8
Peritoneal GATA6+ macrophage drives hepatic immunopathogenesis and maintains the Treg cell niche in the liver	8
Neutrophils in secondary lymphoid organs	8
SNX17 Regulates Antigen Internalisation and Phagosomal Maturation by Dendritic Cells	8
Transcriptomic landscape of skin lesions in cutaneous leishmaniasis reveals a strong CD8+ T cell immunosenescence signature linked to immunopathology	8
CD5L is upregulated upon infection with Mycobacterium tuberculosis with no effect on disease progression	8
Regulatory B cells protect against chronic hypoxia‐induced pulmonary hypertension by modulating the Tfh/Tfr immune balance	8
NR4A1 mediates NK‐cell dysfunction in hepatocellular carcinoma via the IFN‐γ/p‐STAT1/IRF1 pathway	8
Critical roles of the E3 ubiquitin ligase FBW7 in B‐cell response and the pathogenesis of experimental autoimmune arthritis	8
Impact of sex differences on the clinical presentation, pathogenesis, treatment and prognosis of Sjögren's syndrome	8
Pellino3 ligase negatively regulates influenza B dependent RIG‐I signalling through downregulation of TRAF3‐mediated induction of the transcription factor IRF3 and	8
Downregulation of type I interferon signalling pathway by urate in primary human PBMCs	8
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Coexistence of IL12Rβ1 and BTK Mutations in a Family	8
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Use of a Foamy‐Virus Vector System to Produce an ‘Off‐the‐Shelf’ Fcγ‐CR‐T Cell Product for the Treatment of Haematological and Solid Tumour Malignancies	8
The functional diversity of tissue‐resident natural killer cells against infection	8
Clinical C3 Inhibition With AMY‐101 Reveals Novel Insights Into IL‐8‐Driven Inflammation in COVID‐19	8
Impact of Pre‐Infection COVID‐19 Vaccination on the Incidence and Severity of Long COVID: A Retrospective Case–Control Study	7
How maternal factors shape the immune system of breastfed infants to alleviate food allergy: A systematic and updated review	7
Engineered polyspecific antibodies: A new frontier in the field of immunotherapeutics	7
Immunoparalysis in critically ill children	7
The Role of Innate Immunity in Healthy Aging Through Antimicrobial Peptides	7
TRAF5 regulates intestinal mucosal Th1/Th17 cell immune responses via Runx1 in colitis mice	7
Identifying SARS‐CoV‐2 ‘memory’ NK cells from COVID‐19 convalescent donors for adoptive cell therapy	7
Expression of GPR56 reflects a hypoactivated state of circulating B cells and is downregulated in B cell subsets in patients with early‐stage lung adenocarcinoma	7
BCG‐mediated protection against M. tuberculosis is sustained post‐malaria infection independent of parasite virulence	7
A Review on Biosensors for Quantification of MCP‐1 as a Potential Biomarker in Diseases	7
Computer Integrated Dominant Epitopes Evoke Protective Immune Response Against Streptococcus pneumoniae	7
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Unlocking the role of the B7‐H4 polymorphism in psoriasis: Insights into methotrexate treatment outcomes: A prospective cohort study	7
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Break down the barriers of auto‐inflammation: How to deal with a monogenic auto‐inflammatory disease and immuno‐haematological features in 2022?	7
NKG2A‐checkpoint inhibition and its blockade critically depends on peptides presented by its ligand HLA‐E	7
Increased CD8dim and Decreased CD8bright T Cells as Immunological Signature for Multibacilary Leprosy Patients	7
New sights of low dose IL‐2: Restoration of immune homeostasis for viral infection	7
Effector immune cells in chronic lung allograft dysfunction: A systematic review	7
Abrogation and homeostatic restoration of IgE responses by a universal IgE allergy CTL vaccine—The three signal self/non‐self/self (S/NS/S) theor	7
RNA technology and nanocarriers empowering in vivo chimeric antigen receptor therapy	7
Our evolving view of neutrophils in defining the pathology of chronic lung disease	6
Application and Perspectives of Immunotherapy in Head and Neck Squamous Cell Carcinoma	6
Featured Cover	6
SAA1 as a Potential Early Diagnostic Biomarker for Sepsis Through Integrated Proteomics and Metabolomics	6
Elucidation of the signalling pathways for enhanced exosome release from Mycobacterium‐infected macrophages and subsequent induction of differentiation	6
Immunomodulatory functions of TRPM7 and its implications in autoimmune diseases	6
Cellular landscape of tumour microenvironment in prostate cancer	6
PCK2 maintains intestinal homeostasis and prevents colitis by protecting antibody‐secreting cells from oxidative stress	6
USP12 positively regulates M‐MDSC function to inhibit antitumour immunity through deubiquitinating and stabilizing p65	6
Icariin Induces Chondrocyte Degeneration via Activation of the NF‐κB Signalling Pathway and Reduces the Inflammation Factor Expression Induced by Lipopolysaccharide	6
NK‐cell exhaustion, B‐cell exhaustion and T‐cell exhaustion—the differences and similarities	6
Involvement of Janus kinase‐dependent Bcl‐xL overexpression in steroid resistance of group 2 innate lymphoid cells in asthma	6
The turning point of COVID‐19 severity is associated with a unique circulating neutrophil gene signature	6
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Metabolomic and lipidomic signatures associated with activation of human cDC1 (BDCA3+/CD141+) dendritic cells	6
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The dual role of regulatory T cells in hepatitis B virus infection and related hepatocellular carcinoma	6
Role of novel protein acylation modifications in immunity and its related diseases	6
Eleven‐month longitudinal study of antibodies in SARS‐CoV‐2 exposed and naïve primary health care workers upon COVID‐19 vaccination	6
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Inhibition of leukotriene‐B4 signalling‐mediated host response to tuberculosis is a potential mode of adjunctive host‐directed therapy	6
Mycobacterium avium Subsp. paratuberculosis and Human Endogenous Retrovirus in Italian Patients With Inflammatory Bowel Disease (IBD) and Irritable Bowel	5
Chromatin‐binding deubiquitinase MYSM1 acts in haematopoietic progenitors to control dendritic cell development and to program dendritic cell responses to microbial stimulation	5
Effect of gut flora mediated‐bile acid metabolism on intestinal immune microenvironment	5
Advancements in Nipah virus treatment: Analysis of current progress in vaccines, antivirals, and therapeutics	5
Mycobacterium vaccae alleviates allergic airway inflammation and airway hyper‐responsiveness in asthmatic mice by altering intestinal microbiota	5
Monocyte pathology in human tuberculosis is due to plasma milieu changes and aberrant STAT signalling	5
Upregulated TCF1+ Treg Cells With Stronger Function in Systemic Lupus Erythematosus Through Activation of the Wnt‐β‐Catenin	5
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PKCζ activation promotes maturation of cord blood T cells towards a Th1 IFN‐γ propensity	5
Keap1 moderates the transcription of virus induced genes through G9a‐GLP and NFκB p50 recruitment	5
Pathogenetic role and clinical significance of interleukin‐1β in cancer	5
Circular RNA ACTR2 activates M2 polarization of macrophages through activating Yes‐associated protein signalling and contributes to renal fibrosis	5
Roles of S100A8, S100A9 and S100A12 in infection, inflammation and immunity	5
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Targeting Immune Cell Metabolism: A Promising Therapeutic Approach for Cardiovascular Disease	5
Dopaminergic inhibition of human neutrophils is exerted through D1‐like receptors and affected by bacterial infection	5
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Heat inactivated mycobacteria, alpha‐Gal and zebrafish: Insights gained from experiences with two promising trained immunity inductors and a validated animal model	5
Unravelling CD4+ T cell diversity and tissue adaptation of Tregs in abdominal aortic aneurysms through single‐cell sequencing	5
Deubiquitinase inhibitor PR‐619 potentiates colon cancer immunotherapy by inducing ferroptosis	5
IL‐2 amplifies quantitative TCR signalling inputs to drive Th1 and Th2 differentiation	5
B Cells as a Host of Persistent Salmonella Typhimurium	5
Haemocyte‐mediated immunity in insects: Cells, processes and associated components in the fight against pathogens and parasites	5
Advancement in the development of mRNA‐based vaccines for respiratory viruses	4
SOX17 orchestrates immune evasion in early colorectal adenomas and cancers	4
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Endogenous ERMAP Affects T‐Cell Function in EAE Mice	4
PD‐1 Regulates the Glycolytic Pathway to Reverse Abnormal CD4+ T Cell Differentiation and Alleviate Hashimoto's Thyroiditis	4
HLA‐dependent variation in SARS‐CoV‐2 CD8 + T cell cross‐reactivity with human coronaviruses	4
Editorial: Diverse responses to SARS‐CoV‐2 in the human population	4
Prevalence of salivary anti‐SARS‐CoV‐2 IgG antibodies in vaccinated children	4
The dephosphorylation of FADD at S191 induces an excessive expansion of TCRαβ+IELs in the intestinal mucosa	4
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Applications of single‐cell omics for chimeric antigen receptor T cell therapy	4