FEBS Letters

Article	Citations
Mitochondrial DNA copy number in human disease: the more the better?	207
The promise and the challenges of cryo‐electron tomography	168
Structural and functional diversity calls for a new classification of ABC transporters	165
Enhanced binding of the N501Y‐mutated SARS‐CoV‐2 spike protein to the human ACE2 receptor: insights from molecular dynamics simulations	154
Mitochondrial dynamics in health and disease	126
Mitochondrial disorders of the OXPHOS system	118
Recent advances in understanding catalysis of protein folding by molecular chaperones	108
G Protein‐Coupled receptors and heterotrimeric G proteins as cancer drivers	82
Coupled network of the circadian clocks: a driving force of rhythmic physiology	64
Mitochondria, energy, and metabolism in neuronal health and disease	58
Restriction point regulation at the crossroads between quiescence and cell proliferation	49
Extracellular vesicles and intercellular communication in the central nervous system	48
Mitochondrial protein import dysfunction: mitochondrial disease, neurodegenerative disease and cancer	47
MICOS and the mitochondrial inner membrane morphology – when things get out of shape	43
The Diseased Mitoribosome	42
The raw truth about paper mills	39
The cytochrome bc1 complex as an antipathogenic target	38
Lipopolysaccharide and the gut microbiota: considering structural variation	38
The ambivalent role of water at the origins of life	37
Sphingolipids in plants: a guidebook on their function in membrane architecture, cellular processes, and environmental or developmental responses	35
Recent advances in the role of sphingosine 1‐phosphate in cancer	35
The ABCG2/BCRP transporter and its variants – from structure to pathology	35
The role of the degenerate nucleotide binding site in type I ABC exporters	34
Structures of ABC transporters: handle with care	34
Mitochondrial turnover and homeostasis in ageing and neurodegeneration	33

Munc13 binds and recruits SNAP25 to chaperone SNARE complex assembly	32
The role of sphingolipids in endoplasmic reticulum stress	32
Adenoviruses – Infection, pathogenesis and therapy	30
Transcription factors and ABC transporters: from pleiotropic drug resistance to cellular signaling in yeast	29
Complement evasion strategies of Borrelia burgdorferi sensu lato	29
Resveratrol reduces cardiac NLRP3‐inflammasome activation and systemic inflammation to lessen doxorubicin‐induced cardiotoxicity in juvenile mice	29
The ergothioneine transporter (ETT): substrates and locations, an inventory	28
Targeting glycosphingolipids for cancer immunotherapy	28
The molecular pathology of pathogenic mitochondrial tRNA variants	28
Mitochondrial clearance: mechanisms and roles in cellular fitness	28
The human gut microbiota is neither an organ nor a commensal	28
Internalisation and toxicity of amyloid‐β 1‐42 are influenced by its conformation and assembly state rather than size	27
The degree of unsaturation of fatty acids in phosphatidylserine alters the rate of insulin aggregation and the structure and toxicity of amyloid aggregates	27
Evolutionary history of ATP‐binding cassette proteins	27
Fibroblast‐mediated intercellular crosstalk in the healthy and diseased heart	27
An inventory of lysosomal ABC transporters	27
Self‐immunity to antibacterial peptides by ABC transporters	27
The impact of reductants on the catalytic efficiency of a lytic polysaccharide monooxygenase and the special role of dehydroascorbic acid	27
Small RNAs in epigenetic inheritance: from mechanisms to trait transmission	26
Complement in sepsis—when science meets clinics	26
Genetic basis of mitochondrial diseases	26
Importance of protein Ser/Thr/Tyr phosphorylation for bacterial pathogenesis	25
ddhCTP produced by the radical‐SAM activity of RSAD2 (viperin) inhibits the NAD+‐dependent activity of enzymes to modulate metabolism	25
Single‐dose immunisation with a multimerised SARS‐CoV‐2 receptor binding domain (RBD) induces an enhanced and protective response in mice	25
Aggregation and mobility of membrane proteins interplay with local lipid order in the plasma membrane of T cells	25
Tubulin mutations in neurodevelopmental disorders as a tool to decipher microtubule function	24
ABC‐F translation factors: from antibiotic resistance to immune response	24
From clocks to dominoes: lessons on cell cycle remodelling from embryonic stem cells	24
The palette of techniques for cell cycle analysis	24
ABCB1/MDR1/P‐gp employs an ATP‐dependent twist‐and‐squeeze mechanism to export hydrophobic drugs	24
Transposable elements as new players in neurodegenerative diseases	24
The circadian clock and diseases of the skin	24
Sharing biological data: why, when, and how	24
Organization of gangliosides into membrane nanodomains	23
The golgin family exhibits a propensity to form condensates in living cells	23
Genome‐wide analysis and transcriptional regulation of the typical and atypical thioredoxins in Arabidopsis thaliana	23
Nonenzymatic oxygenated metabolite of docosahexaenoic acid, 4(RS)‐4‐F4t‐neuroprostane, acts as a bioactive lipid molecule in neuronal cells	22
SARS‐CoV‐2 spike glycoprotein‐binding proteins expressed by upper respiratory tract bacteria may prevent severe viral infection	22
Mitochondrial proteases in human diseases	22
The Adenovirus Death Protein – a small membrane protein controls cell lysis and disease	22
The proteasome: friend and foe of mitochondrial biogenesis	22
Role of cytoplasmic dynein and kinesins in adenovirus transport	22
ASC‐1 transporter‐dependent amino acid uptake is required for the efficient thermogenic response of human adipocytes to adrenergic stimulation	22
The coxsackievirus and adenovirus receptor: virological and biological beauty	22
Knowledge‐based structural models of SARS‐CoV‐2 proteins and their complexes with potential drugs	21
Looking back at multidrug resistance (MDR) research and ten mistakes to be avoided when writing about ABC transporters in MDR	21
A Hitchhiker's guide through the bio‐image analysis software universe	21
Mass spectrometry‐based abundance atlas of ABC transporters in human liver, gut, kidney, brain and skin	21
Molecular dissection of ALS‐linked TDP‐43 – involvement of the Gly‐rich domain in interaction with G‐quadruplex mRNA	21
Synthetic biology principles for the design of protein with novel structures and functions	20

Small molecule 3PO inhibits glycolysis but does not bind to 6‐phosphofructo‐2‐kinase/fructose‐2,6‐bisphosphatase‐3 (PFKFB3)	20
The cross‐talk between Abl2 tyrosine kinase and TGFβ1 signalling modulates the invasion of clear cell Renal Cell Carcinoma cells	19
Neuronatin promotes SERCA uncoupling and its expression is altered in skeletal muscles of high‐fat diet‐fed mice	19
Understanding oncogenicity of cancer driver genes and mutations in the cancer genomics era	19
Health consequences of improving the content of ergothioneine in the food supply	19
TOR kinase activity in Chlamydomonas reinhardtii is modulated by cellular metabolic states	19
Sphingolipid‐enriched domains in fungi	19
LRRK2 phosphorylation of Rab GTPases in Parkinson's disease	19
The role of exosomes in intercellular and inter‐organ communication of the peripheral nervous system	19
Interface‐based design of the favipiravir‐binding site in SARS‐CoV‐2 RNA‐dependent RNA polymerase reveals mutations conferring resistance to chain termination	19
Voltage‐gating of aquaporins, a putative conserved safety mechanism during ionic stresses	18
Fluorescence CLEM in biology: historic developments and current super‐resolution applications	18
The Saccharomyces cerevisiae ABC subfamily D transporter Pxa1/Pxa2p co‐imports CoASH into the peroxisome	18
Expanding role of PI5P4Ks in cancer: A promising druggable target	18
Why do pathway methods work better than they should?	18
Autophagy in plant viral infection	17
Cryo‐EM of ABC transporters: an ice‐cold solution to everything?	17
A weak COPI binding motif in the cytoplasmic tail of SARS‐CoV‐2 spike glycoprotein is necessary for its cleavage, glycosylation, and localization	17
Bioinorganic supramolecular coordination complexes and their biomedical applications	17
Crystal structure of the human NLRP9 pyrin domain suggests a distinct mode of inflammasome assembly	17
α‐Synuclein phase separation and amyloid aggregation are modulated by C‐terminal truncations	16
Local and systemic effects of interleukin‐6 (IL‐6) in inflammation and cancer	16
Diet‐derived ergothioneine induces necroptosis in colorectal cancer cells by activating the SIRT3/MLKL pathway	16
Serum levels of the IgA isotype switch factor TGF‐β1 are elevated in patients with COVID‐19	16
CAR‐Ts: new perspectives in cancer therapy	16
AP‐1 and NF‐κB synergize to transcriptionally activate latent HIV upon T‐cell receptor activation	16
Meningococcal factor H binding protein as immune evasion factor and vaccine antigen	15
A twist in the ABC: regulation of ABC transporter trafficking and transport by FK506‐binding proteins	15
Ergothioneine in the brain	15
Sphingolipids controlling ciliary and microvillar function	15
The splicing regulatory factor hnRNPU is a novel transcriptional target of c‐Myc in hepatocellular carcinoma	15
Picky ABCG5/G8 and promiscuous ABCG2 ‐ a tale of fatty diets and drug toxicity	15
Synthetic in vitro transcribed lncRNAs (SINEUPs) with chemical modifications enhance target mRNA translation	15
Matching chemical properties to molecular biological activities opens a new perspective on l‐ergothioneine	15
Conformational changes in the nucleotide‐binding domains of P‐glycoprotein induced by ATP hydrolysis	15
Streptococci and the complement system: interplay during infection, inflammation and autoimmunity	15
SARS‐CoV‐2 nucleocapsid protein interacts with immunoregulators and stress granules and phase separates to form liquid droplets	15
An updated classification and mechanistic insights into ligand binding of the substrate‐binding proteins	15
Creative communication – using poetry and games to generate dialogue between scientists and nonscientists	14
Porphyromonas gingivalis enhances pneumococcal adhesion to human alveolar epithelial cells by increasing expression of host platelet‐activating factor receptor	14
Siglec‐15 promotes the migration of liver cancer cells by repressing lysosomal degradation of CD44	14
ABC proteins in evolution	14
SGK1 is a signalling hub that controls protein synthesis and proliferation in endothelial cells	14
The chromatin modifier MORC2 affects glucose metabolism by regulating the expression of lactate dehydrogenase A through a feed forward loop with c‐Myc	14
The crystal structure of a Fusarium oxysporum feruloyl esterase that belongs to the tannase family	14
Glycans as a key factor in self and nonself discrimination: impact on the breach of immune tolerance	14
Transcriptional shifts in delignification‐defective mutants of the white‐rot fungus Pleurotus ostreatus	14
Cholino‐ncRNAs modulate sex‐specific‐ and age‐related acetylcholine signals	14
Neurological pathophysiology of SARS‐CoV‐2 and pandemic potential RNA viruses: a comparative analysis	14
Cryo‐EM structure of the ribosome functional complex of the human pathogen Staphylococcus aureus at 3.2 Å resolution	14
Genome‐scale metabolic modelling of SARS‐CoV‐2 in cancer cells reveals an increased shift to glycolytic energy production	14
Connections between laboratory research and climate change: what scientists and policy makers can do to reduce environmental impacts	14
CircRNAs in gastric cancer: current research and potential clinical implications	13
Vesicle capture by membrane‐bound Munc13‐1 requires self‐assembly into discrete clusters	13
Proteolytic cleavage of Trop2 at Arg87 is mediated by matriptase and regulated by Val194	13
Crystal structure of the human NLRP9 pyrin domain reveals a bent N‐terminal loop that may regulate inflammasome assembly	13
Cardiolipin deficiency in Barth syndrome is not associated with increased superoxide/H2O2 production in heart and skeletal muscle mitochondria	13
Galectin‐1–RNA interaction map reveals potential regulatory roles in angiogenesis	13
The imitation game: a viral strategy to subvert the complement system	13
The coordinated action of glucuronoyl esterase and α‐glucuronidase promotes the disassembly of lignin–carbohydrate complexes	13
What monomeric nucleotide binding domains can teach us about dimeric ABC proteins	13
Decline of ergothioneine in frailty and cognition impairment	13
Calcium transfer between endoplasmic reticulum and mitochondria in liver diseases	13
The D1:Ser268 residue of Photosystem II contributes to an alternative pathway for QB protonation in the absence of bound bicarbonate	13
Biological nitrogen fixation in theory, practice, and reality: a perspective on the molybdenum nitrogenase system	13
Proline‐rich extensin‐like receptor kinases PERK5 and PERK12 are involved in pollen tube growth	13
The histidine brace: nature's copper alternative to haem?	13
Pseudouridines in RNAs: switching atoms means shifting paradigms	13
Exocyst functions in plants: secretion and autophagy	12
Ablation of fatty acid desaturase 2 (FADS2) exacerbates hepatic triacylglycerol and cholesterol accumulation in polyunsaturated fatty acid‐depleted mice	12
Soluble forms of cytokine and growth factor receptors: mechanisms of generation and modes of action in the regulation of local and systemic inflammation	12
The SLIM1 transcription factor is required for arsenic resistance in Arabidopsis thaliana	12
Conformational changes of DNA repair glycosylase MutM triggered by DNA binding	12
Human SND2 mediates ER targeting of GPI‐anchored proteins with low hydrophobic GPI attachment signals	12
The mechanics of the heart: zooming in on hypertrophic cardiomyopathy and cMyBP‐C	12
SHP‐1 ameliorates nonalcoholic steatohepatitis by inhibiting proinflammatory cytokine production	12
AKT controls NLRP3 inflammasome activation by inducing DDX3X phosphorylation	12
Disruption of small molecule transporter systems by Transporter‐Interfering Chemicals (TICs)	12
Structural characterization of an Arf dimer interface: molecular mechanism of Arf‐dependent membrane scission	12
The complex roles of autophagy in plant immunity	12

Transcriptomic analyses suggest that mucopolysaccharidosis patients may be less susceptible to COVID‐19	12
Human fibroblast‐derived extracellular vesicles promote hair growth in cultured human hair follicles	12
Plant endosomes as protein sorting hubs	11
NRG/ErbB signaling regulates neonatal muscle growth but not neuromuscular contractures in neonatal brachial plexus injury	11
Why science education is more important than most scientists think	11
Bacterial multi‐solute transporters	11
The involvement of sodium in the function of the human amino acid transporter ASCT2	11
Chemical effects on dye efflux activity in live zebrafish embryos and on zebrafish Abcb4 ATPase activity	11
Dynamin‐related protein 1 positively regulates osteoclast differentiation and bone loss	11
From in vitro towards in situ: structure‐based investigation of ABC exporters by electron paramagnetic resonance spectroscopy	11
The Microglial membrane receptor TREM2 mediates exosome secretion to promote phagocytosis of amyloid‐β by microglia	11
Acetate overflow metabolism regulates a major metabolic shift after glucose depletion in Escherichia coli	11
Low oxygen tension differentially regulates the expression of placental solute carriers and ABC transporters	11
Reductants fuel lytic polysaccharide monooxygenase activity in a pH‐dependent manner	11
The default cyanobacterial linked genome: an interactive platform based on cyanobacterial linkage networks to assist functional genomics	11
Crystal structure of the Enterococcus faecalis α‐N‐acetylgalactosaminidase, a member of the glycoside hydrolase family 31	11
Engineering ergothioneine production in Yarrowia lipolytica	11
Periostin deficiency attenuates lipopolysaccharide‐ and obesity‐induced adipose tissue fibrosis	11
Identification of two subtilisin‐like serine proteases engaged in the degradation of recombinant proteins in Nicotiana benthamiana	11
Plant cytokinesis and the construction of new cell wall	11
Gene network analysis using SWIM reveals interplay between the transcription factor‐encoding genes HMGA1, FOXM1, and MYBL2 in triple‐negative breast cancer	11
Annexins A1 and A2 are recruited to larger lysosomal injuries independently of ESCRTs to promote repair	11
Mitochondrial [2Fe‐2S] ferredoxins: new functions for old dogs	11
Exosome‐associated polysialic acid modulates membrane potentials, membrane thermotropic properties, and raft‐dependent interactions between vesicles	10
The RNA demethylase ALKBH5 promotes osteoblast differentiation by modulating Runx2 mRNA stability	10
Apolipoprotein A‐I in mouse cerebrospinal fluid derives from the liver and intestine via plasma high‐density lipoproteins assembled by ABCA1 and LCAT	10
The sphingolipid anteome: implications for evolution of the sphingolipid metabolic pathway	10
Metabolism and autophagy in plants—a perfect match	10
New mechanistic insights into coupled binuclear copper monooxygenases from the recent elucidation of the ternary intermediate of tyrosinase	10
Different recognition modes of G‐quadruplex RNA between two ALS/FTLD‐linked proteins TDP‐43 and FUS	10
Strategies for cystic fibrosis transmembrane conductance regulator inhibition: from molecular mechanisms to treatment for secretory diarrhoeas	10
Cleavage of the outer membrane protein OmpX by protealysin regulates Serratia proteamaculans invasion	10
Novel and conventional inhibitors of canonical autophagy differently affect LC3‐associated phagocytosis	10
Complement in malaria: immune evasion strategies and role in protective immunity	10
Interorgan crosstalk in pancreatic islet function and pathology	10
Interactions between autophagy and phytohormone signaling pathways in plants	9
The mitochondrial regulator PGC1α is induced by cGMP–PKG signaling and mediates the protective effects of phosphodiesterase 5 inhibition in heart failure	9
PARP1–RNA interaction analysis: PARP1 regulates the expression of extracellular matrix‐related genes in HK‐2 renal proximal tubular epithelial cells	9
Coronavirus SARS‐CoV‐2: filtering fact from fiction in the infodemic	9
Long noncoding RNAs in cardiometabolic disorders	9
The bridge helix of Cas12a imparts selectivity in cis‐DNA cleavage and regulates trans‐DNA cleavage	9
Fatty acid‐binding protein 5 controls lung tumor metastasis by regulating the maturation of natural killer cells in the lung	9
Single‐molecule studies of conformational states and dynamics in the ABC importer OpuA	9
Membrane contact sites and cytoskeleton‐membrane interactions in autophagy	9
Dynamics and electrostatics define an allosteric druggable site within the receptor‐binding domain of SARS‐CoV‐2 spike protein	9
NAD+/sirtuin metabolism is enhanced in response to cold‐induced changes in lipid metabolism in mouse liver	9
Cryo‐EM structure of the full‐length Lon protease from Thermus thermophilus	9
A switchable ceramide transfer protein for dissecting the mechanism of ceramide‐induced mitochondrial apoptosis	9
Ergothioneine, where are we now?	9
Water oxidation in oxygenic photosynthesis studied by magnetic resonance techniques	9
The Arabidopsis thaliana mRNA decay factor PAT1 functions in osmotic stress responses and decaps ABA‐responsive genes	9
Knockdown of genes involved in axonal transport enhances the toxicity of human neuromuscular disease‐linked MATR3 mutations in Drosophila	9
CTRP12 inhibits triglyceride synthesis and export in hepatocytes by suppressing HNF‐4α and DGAT2 expression	9
Substrate specificities of inteins investigated by QuickDrop‐cassette mutagenesis	9
Multi‐network logistic matrix factorization for metabolite–disease interaction prediction	9
Tripartite transporters as mechanotransmitters in periplasmic alternating‐access mechanisms	9
ABRO1 stabilizes the deubiquitinase BRCC3 through inhibiting its degradation mediated by the E3 ubiquitin ligase WWP2	9
Targeting RIPK3 oligomerization blocks necroptosis without inducing apoptosis	9
Cardiolipin prevents pore formation in phosphatidylglycerol bacterial membrane models	9
A novel function of Mycobacterium tuberculosis chaperonin paralog GroEL1 in copper homeostasis	9
MYB‐like transcription factor NoPSR1 is crucial for membrane lipid remodeling under phosphate starvation in the oleaginous microalga Nannochloropsis oceanica	9
ΔNp63 is upregulated during salivary gland regeneration following duct ligation and irradiation in mice	9
Arrangements of proteins at reconstituted synaptic vesicle fusion sites depend on membrane separation	8
From membrane to mineralization: the curious case of the ABCC6 transporter	8
Epsin but not AP‐2 supports reconstitution of endocytic clathrin‐coated vesicles	8
Endothelial cell autophagy in homeostasis and cancer	8
SARS‐CoV‐2 spike protein aggregation is triggered by bacterial lipopolysaccharide	8
ER‐to‐lysosome‐associated degradation in a nutshell: mammalian, yeast, and plant ER‐phagy as induced by misfolded proteins	8
Analysis of the structure and substrate scope of chitooligosaccharide oxidase reveals high affinity for C2‐modified glucosamines	8
RAS nanoclusters are cell surface transducers that convert extracellular stimuli to intracellular signalling	8
Plant type I metacaspases are proteolytically active proteases despite their hydrophobic nature	8
Immunometabolic function of the transcription cofactor VGLL3 provides an evolutionary rationale for sexual dimorphism in autoimmunity	8
COPII vesicles in plant autophagy and endomembrane trafficking	8
Bone morphogenetic protein 9 (BMP9) directly induces Notch effector molecule Hes1 through the SMAD signaling pathway in osteoblasts	8
Senile plaques in Alzheimer's disease arise from Aβ‐ and Cathepsin D‐enriched mixtures leaking out during intravascular haemolysis and microaneurysm rupture	8
Plasmodium falciparum HSP40 protein eCiJp traffics to the erythrocyte cytoskeleton and interacts with the human HSP70 chaperone HSPA1	8
Cytosolic PINK1 orchestrates protein translation during proteasomal stress by phosphorylating the translation elongation factor eEF1A1	8
Roles of peripheral clocks: lessons from the fly	8
Coronin 2B regulates dendrite outgrowth by modulating actin dynamics	8
Osteocalcin and the physiology of danger	8
Chloroplastic ascorbate peroxidases targeted to stroma or thylakoid membrane: The chicken or egg dilemma	8
Structural features of the plant N‐recognin ClpS1 and sequence determinants in its targets that govern substrate selection	8
Phosphorylation of NANOG by casein kinase I regulates embryonic stem cell self‐renewal	8
Capturing the sequence of events during the water oxidation reaction in photosynthesis using XFELs	8
The attachment of a DNA‐binding Sso7d‐like protein improves processivity and resistance to inhibitors of M‐MuLV reverse transcriptase	8
Cascading proton transfers are a hallmark of the catalytic mechanism of SAM‐dependent methyltransferases	8
Crystal structures of the sheeppox virus encoded inhibitor of apoptosis SPPV14 bound to the proapoptotic BH3 peptides Hrk and Bax	8
Identification of chemical compounds regulating PD‐L1 by introducing HiBiT‐tagged cells	8
The structure of COPI vesicles and regulation of vesicle turnover	8
Comparative characterization of nine novel GH51, GH54 and GH62 α‐l‐arabinofuranosidases from Penicillium subrubescens	8
A glycosaminoglycan microarray identifies the binding of SARS‐CoV‐2 spike protein to chondroitin sulfate E	8
Metabolic syndrome perturbs deglucosylation and reglucosylation in the glycoprotein folding cycle	8
Brachypodium BdABCG25 is a homolog of Arabidopsis AtABCG25 involved in the transport of abscisic acid	8
Protein metalation in a nutshell	8
Meprin and ADAM proteases as triggers of systemic inflammation in sepsis	8