FEBS Letters

Papers
(The TQCC of FEBS Letters is 6. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-10-01 to 2024-10-01.)
ArticleCitations
Mitochondrial DNA copy number in human disease: the more the better?251
The promise and the challenges of cryo‐electron tomography203
Structural and functional diversity calls for a new classification of ABC transporters184
Mitochondrial dynamics in health and disease156
Enhanced binding of the N501Y‐mutated SARS‐CoV‐2 spike protein to the human ACE2 receptor: insights from molecular dynamics simulations155
Mitochondrial disorders of the OXPHOS system142
G Protein‐Coupled receptors and heterotrimeric G proteins as cancer drivers93
Mitochondria, energy, and metabolism in neuronal health and disease76
Mitochondrial protein import dysfunction: mitochondrial disease, neurodegenerative disease and cancer61
Extracellular vesicles and intercellular communication in the central nervous system60
The raw truth about paper mills55
Lipopolysaccharide and the gut microbiota: considering structural variation53
MICOS and the mitochondrial inner membrane morphology – when things get out of shape50
The Diseased Mitoribosome50
Transcription factors and ABC transporters: from pleiotropic drug resistance to cellular signaling in yeast43
Sphingolipids in plants: a guidebook on their function in membrane architecture, cellular processes, and environmental or developmental responses42
The ABCG2/BCRP transporter and its variants – from structure to pathology40
Sharing biological data: why, when, and how39
Recent advances in the role of sphingosine 1‐phosphate in cancer39
The ergothioneine transporter (ETT): substrates and locations, an inventory38
Fibroblast‐mediated intercellular crosstalk in the healthy and diseased heart37
The role of the degenerate nucleotide binding site in type I ABC exporters37
Munc13 binds and recruits SNAP25 to chaperone SNARE complex assembly36
Structures of ABC transporters: handle with care34
The cross‐talk between Abl2 tyrosine kinase and TGFβ1 signalling modulates the invasion of clear cell Renal Cell Carcinoma cells34
The circadian clock and diseases of the skin34
Genetic basis of mitochondrial diseases33
The human gut microbiota is neither an organ nor a commensal33
Resveratrol reduces cardiac NLRP3‐inflammasome activation and systemic inflammation to lessen doxorubicin‐induced cardiotoxicity in juvenile mice32
The degree of unsaturation of fatty acids in phosphatidylserine alters the rate of insulin aggregation and the structure and toxicity of amyloid aggregates32
An inventory of lysosomal ABC transporters32
Mitochondrial clearance: mechanisms and roles in cellular fitness31
Aggregation and mobility of membrane proteins interplay with local lipid order in the plasma membrane of T cells31
Small RNAs in epigenetic inheritance: from mechanisms to trait transmission31
The molecular pathology of pathogenic mitochondrial tRNA variants31
Evolutionary history of ATP‐binding cassette proteins31
Self‐immunity to antibacterial peptides by ABC transporters30
LRRK2 phosphorylation of Rab GTPases in Parkinson's disease30
The impact of reductants on the catalytic efficiency of a lytic polysaccharide monooxygenase and the special role of dehydroascorbic acid30
A Hitchhiker's guide through the bio‐image analysis software universe30
Transposable elements as new players in neurodegenerative diseases29
ABCB1/MDR1/P‐gp employs an ATP‐dependent twist‐and‐squeeze mechanism to export hydrophobic drugs28
Single‐dose immunisation with a multimerised SARS‐CoV‐2 receptor binding domain (RBD) induces an enhanced and protective response in mice28
ABC‐F translation factors: from antibiotic resistance to immune response27
Genome‐wide analysis and transcriptional regulation of the typical and atypical thioredoxins in Arabidopsis thaliana27
Tubulin mutations in neurodevelopmental disorders as a tool to decipher microtubule function26
Health consequences of improving the content of ergothioneine in the food supply26
The proteasome: friend and foe of mitochondrial biogenesis26
The role of exosomes in intercellular and inter‐organ communication of the peripheral nervous system26
Mitochondrial proteases in human diseases25
Neuronatin promotes SERCA uncoupling and its expression is altered in skeletal muscles of high‐fat diet‐fed mice25
Autophagy in plant viral infection25
Looking back at multidrug resistance (MDR) research and ten mistakes to be avoided when writing about ABC transporters in MDR24
ASC‐1 transporter‐dependent amino acid uptake is required for the efficient thermogenic response of human adipocytes to adrenergic stimulation24
Expanding role of PI5P4Ks in cancer: A promising druggable target24
Sphingolipid‐enriched domains in fungi23
Pseudouridines in RNAs: switching atoms means shifting paradigms22
α‐Synuclein phase separation and amyloid aggregation are modulated by C‐terminal truncations22
Interface‐based design of the favipiravir‐binding site in SARS‐CoV‐2 RNA‐dependent RNA polymerase reveals mutations conferring resistance to chain termination22
Mass spectrometry‐based abundance atlas of ABC transporters in human liver, gut, kidney, brain and skin22
AP‐1 and NF‐κB synergize to transcriptionally activate latent HIV upon T‐cell receptor activation22
Fluorescence CLEM in biology: historic developments and current super‐resolution applications21
Diet‐derived ergothioneine induces necroptosis in colorectal cancer cells by activating the SIRT3/MLKL pathway21
Bioinorganic supramolecular coordination complexes and their biomedical applications21
Cryo‐EM of ABC transporters: an ice‐cold solution to everything?21
CAR‐Ts: new perspectives in cancer therapy21
Glycans as a key factor in self and nonself discrimination: impact on the breach of immune tolerance20
Connections between laboratory research and climate change: what scientists and policy makers can do to reduce environmental impacts20
Picky ABCG5/G8 and promiscuous ABCG2 ‐ a tale of fatty diets and drug toxicity20
Why do pathway methods work better than they should?20
The Saccharomyces cerevisiae ABC subfamily D transporter Pxa1/Pxa2p co‐imports CoASH into the peroxisome20
Serum levels of the IgA isotype switch factor TGF‐β1 are elevated in patients with COVID‐1920
Voltage‐gating of aquaporins, a putative conserved safety mechanism during ionic stresses19
Local and systemic effects of interleukin‐6 (IL‐6) in inflammation and cancer19
Matching chemical properties to molecular biological activities opens a new perspective on l‐ergothioneine19
Exocyst functions in plants: secretion and autophagy18
SARS‐CoV‐2 nucleocapsid protein interacts with immunoregulators and stress granules and phase separates to form liquid droplets18
A weak COPI binding motif in the cytoplasmic tail of SARS‐CoV‐2 spike glycoprotein is necessary for its cleavage, glycosylation, and localization18
The mechanics of the heart: zooming in on hypertrophic cardiomyopathy and cMyBP‐C18
Biological nitrogen fixation in theory, practice, and reality: a perspective on the molybdenum nitrogenase system18
The complex roles of autophagy in plant immunity18
Annexins A1 and A2 are recruited to larger lysosomal injuries independently of ESCRTs to promote repair18
Synthetic in vitro transcribed lncRNAs (SINEUPs) with chemical modifications enhance target mRNA translation17
Plant cytokinesis and the construction of new cell wall17
Protein metalation in a nutshell17
Water oxidation in oxygenic photosynthesis studied by magnetic resonance techniques17
New mechanistic insights into coupled binuclear copper monooxygenases from the recent elucidation of the ternary intermediate of tyrosinase17
Ergothioneine in the brain17
An updated classification and mechanistic insights into ligand binding of the substrate‐binding proteins17
The structure of COPI vesicles and regulation of vesicle turnover17
Ablation of fatty acid desaturase 2 (FADS2) exacerbates hepatic triacylglycerol and cholesterol accumulation in polyunsaturated fatty acid‐depleted mice16
Siglec‐15 promotes the migration of liver cancer cells by repressing lysosomal degradation of CD4416
The histidine brace: nature's copper alternative to haem?16
Calcium transfer between endoplasmic reticulum and mitochondria in liver diseases16
A twist in the ABC: regulation of ABC transporter trafficking and transport by FK506‐binding proteins16
Metabolism and autophagy in plants—a perfect match16
Reductants fuel lytic polysaccharide monooxygenase activity in a pH‐dependent manner16
Conformational changes in the nucleotide‐binding domains of P‐glycoprotein induced by ATP hydrolysis16
The chromatin modifier MORC2 affects glucose metabolism by regulating the expression of lactate dehydrogenase A through a feed forward loop with c‐Myc16
Identification of two subtilisin‐like serine proteases engaged in the degradation of recombinant proteins in Nicotiana benthamiana16
Decline of ergothioneine in frailty and cognition impairment16
Genome‐scale metabolic modelling of SARS‐CoV‐2 in cancer cells reveals an increased shift to glycolytic energy production15
Mitochondrial [2Fe‐2S] ferredoxins: new functions for old dogs15
The splicing regulatory factor hnRNPU is a novel transcriptional target of c‐Myc in hepatocellular carcinoma15
Plant endosomes as protein sorting hubs15
The coordinated action of glucuronoyl esterase and α‐glucuronidase promotes the disassembly of lignin–carbohydrate complexes15
ABC proteins in evolution15
Soluble forms of cytokine and growth factor receptors: mechanisms of generation and modes of action in the regulation of local and systemic inflammation15
The Microglial membrane receptor TREM2 mediates exosome secretion to promote phagocytosis of amyloid‐β by microglia15
AKT controls NLRP3 inflammasome activation by inducing DDX3X phosphorylation15
Cardiolipin deficiency in Barth syndrome is not associated with increased superoxide/H2O2 production in heart and skeletal muscle mitochondria15
CircRNAs in gastric cancer: current research and potential clinical implications15
Neurological pathophysiology of SARS‐CoV‐2 and pandemic potential RNA viruses: a comparative analysis15
The small GTPase Sar1, control centre of COPII trafficking15
Galectin‐1–RNA interaction map reveals potential regulatory roles in angiogenesis14
Porphyromonas gingivalis enhances pneumococcal adhesion to human alveolar epithelial cells by increasing expression of host platelet‐activating factor receptor14
The SLIM1 transcription factor is required for arsenic resistance in Arabidopsis thaliana14
Disruption of small molecule transporter systems by Transporter‐Interfering Chemicals (TICs)14
ER‐to‐lysosome‐associated degradation in a nutshell: mammalian, yeast, and plant ER‐phagy as induced by misfolded proteins14
Vesicle capture by membrane‐bound Munc13‐1 requires self‐assembly into discrete clusters14
Human fibroblast‐derived extracellular vesicles promote hair growth in cultured human hair follicles14
The sphingolipid anteome: implications for evolution of the sphingolipid metabolic pathway14
RhoA regulation in space and time14
Engineering ergothioneine production in Yarrowia lipolytica14
Chemical effects on dye efflux activity in live zebrafish embryos and on zebrafish Abcb4 ATPase activity14
Human SND2 mediates ER targeting of GPI‐anchored proteins with low hydrophobic GPI attachment signals13
Proline‐rich extensin‐like receptor kinases PERK5 and PERK12 are involved in pollen tube growth13
Why science education is more important than most scientists think13
The attachment of a DNA‐binding Sso7d‐like protein improves processivity and resistance to inhibitors of M‐MuLV reverse transcriptase13
Capturing the sequence of events during the water oxidation reaction in photosynthesis using XFELs13
Dynamin‐related protein 1 positively regulates osteoclast differentiation and bone loss13
Ergothioneine, where are we now?13
Fatty acid‐binding protein 5 controls lung tumor metastasis by regulating the maturation of natural killer cells in the lung13
Acetate overflow metabolism regulates a major metabolic shift after glucose depletion in Escherichia coli13
Apolipoprotein A‐I in mouse cerebrospinal fluid derives from the liver and intestine via plasma high‐density lipoproteins assembled by ABCA1 and LCAT13
Protein translocation in mitochondria: Sorting out the Toms, Tims, Pams, Sams and Mia12
Radical SAM enzymes: Nature's choice for radical reactions12
COPII vesicles in plant autophagy and endomembrane trafficking12
Periostin deficiency attenuates lipopolysaccharide‐ and obesity‐induced adipose tissue fibrosis12
Strategies for cystic fibrosis transmembrane conductance regulator inhibition: from molecular mechanisms to treatment for secretory diarrhoeas12
Gene network analysis using SWIM reveals interplay between the transcription factor‐encoding genes HMGA1, FOXM1, and MYBL2 in triple‐negative breast cancer12
The Arabidopsis thaliana mRNA decay factor PAT1 functions in osmotic stress responses and decaps ABA‐responsive genes12
Single‐molecule studies of conformational states and dynamics in the ABC importer OpuA12
Interactions between autophagy and phytohormone signaling pathways in plants12
The involvement of sodium in the function of the human amino acid transporter ASCT212
SUMO in the regulation of DNA repair and transcription at nuclear pores12
The RNA demethylase ALKBH5 promotes osteoblast differentiation by modulating Runx2 mRNA stability12
RAS nanoclusters are cell surface transducers that convert extracellular stimuli to intracellular signalling11
Making sense of IL‐6 signalling cues in pathophysiology11
Umbilical cord mesenchymal stem cell‐derived exosomes alleviate collagen‐induced arthritis by balancing the population of Th17 and regulatory T cells11
NRG/ErbB signaling regulates neonatal muscle growth but not neuromuscular contractures in neonatal brachial plexus injury11
Low oxygen tension differentially regulates the expression of placental solute carriers and ABC transporters11
Interorgan crosstalk in pancreatic islet function and pathology11
Long noncoding RNAs in cardiometabolic disorders11
The bridge helix of Cas12a imparts selectivity in cis‐DNA cleavage and regulates trans‐DNA cleavage11
Meprin and ADAM proteases as triggers of systemic inflammation in sepsis11
Senile plaques in Alzheimer's disease arise from Aβ‐ and Cathepsin D‐enriched mixtures leaking out during intravascular haemolysis and microaneurysm rupture11
From membrane to mineralization: the curious case of the ABCC6 transporter11
From in vitro towards in situ: structure‐based investigation of ABC exporters by electron paramagnetic resonance spectroscopy11
Chloroplastic ascorbate peroxidases targeted to stroma or thylakoid membrane: The chicken or egg dilemma11
Cardiolipin prevents pore formation in phosphatidylglycerol bacterial membrane models11
Novel and conventional inhibitors of canonical autophagy differently affect LC3‐associated phagocytosis11
An excess of glycolytic enzymes under glucose‐limited conditions may enable Saccharomyces cerevisiae to adapt to nutrient availability11
Different recognition modes of G‐quadruplex RNA between two ALS/FTLD‐linked proteins TDP‐43 and FUS11
Roles of peripheral clocks: lessons from the fly10
Cryo‐EM structure of the full‐length Lon protease from Thermus thermophilus10
Structural features of the plant N‐recognin ClpS1 and sequence determinants in its targets that govern substrate selection10
ADP‐heptose enables Helicobacter pylori to exploit macrophages as a survival niche by suppressing antigen‐presenting HLA‐II expression10
Membrane contact sites and cytoskeleton‐membrane interactions in autophagy10
DrosophilaTNF/TNFRs: At the crossroad between metabolism, immunity, and tissue homeostasis10
The TRAPP complexes: oligomeric exchange factors that activate the small GTPases Rab1 and Rab1110
The therapeutic capacity of bone marrow MSC‐derived extracellular vesicles in Achilles tendon healing is passage‐dependent and indicated by specific glycans10
A switchable ceramide transfer protein for dissecting the mechanism of ceramide‐induced mitochondrial apoptosis10
A glycosaminoglycan microarray identifies the binding of SARS‐CoV‐2 spike protein to chondroitin sulfate E10
Plant type I metacaspases are proteolytically active proteases despite their hydrophobic nature10
Sterol uptake by the NPC system in eukaryotes: a Saccharomyces cerevisiae perspective10
Maintenance of small molecule redox homeostasis in mitochondria10
Defining the architecture of the human TIM22 complex by chemical crosslinking10
Overexpression of UCP3 decreases mitochondrial efficiency in mouse skeletal muscle in vivo10
SARS‐CoV‐2 spike protein aggregation is triggered by bacterial lipopolysaccharide10
On the role of ubiquinone in the proton translocation mechanism of respiratory complex I10
Vesicle trafficking in Arabidopsis pollen tubes10
The mitochondrial regulator PGC1α is induced by cGMP–PKG signaling and mediates the protective effects of phosphodiesterase 5 inhibition in heart failure10
ABIN1 is a signal‐induced autophagy receptor that attenuates NF‐κB activation by recognizing linear ubiquitin chains10
Cytosolic PINK1 orchestrates protein translation during proteasomal stress by phosphorylating the translation elongation factor eEF1A110
Osteocalcin and the physiology of danger9
Structural biology of DOCK‐family guanine nucleotide exchange factors9
Phosphorylation of NANOG by casein kinase I regulates embryonic stem cell self‐renewal9
Crowding tunes the organization and mechanics of actin bundles formed by crosslinking proteins9
Plasmodium falciparum HSP40 protein eCiJp traffics to the erythrocyte cytoskeleton and interacts with the human HSP70 chaperone HSPA19
Generation of fully functional fluorescent fusion proteins to gain insights into ABCC6 biology9
Heparin promotes rapid fibrillation of the basic parathyroid hormone at physiological pH9
Multiorgan microphysiological systems as tools to interrogate interorgan crosstalk and complex diseases9
Cargo receptors and adaptors for selective autophagy in plant cells9
Membrane trafficking functions of the ANTH/ENTH/VHS domain‐containing proteins in plants9
Turbocharging synaptic transmission9
Astrocytic d‐amino acid oxidase degrades d‐serine in the hindbrain9
Endothelial cell autophagy in homeostasis and cancer9
Global analysis of RNA–protein interactions in TNF‐α induced alternative splicing in metabolic disorders9
ABRO1 stabilizes the deubiquitinase BRCC3 through inhibiting its degradation mediated by the E3 ubiquitin ligase WWP29
Scaffold, mechanics and functions of nuclear lamins9
Lysophosphatidylcholine disrupts cell adhesion and induces anoikis in hepatocytes9
Host–microbiome interactions in nicotinamide mononucleotide (NMN) deamidation9
Abiogenesis through gradual evolution of autocatalysis into template‐based replication9
Dynamics and electrostatics define an allosteric druggable site within the receptor‐binding domain of SARS‐CoV‐2 spike protein9
Tripartite transporters as mechanotransmitters in periplasmic alternating‐access mechanisms9
PARP1–RNA interaction analysis: PARP1 regulates the expression of extracellular matrix‐related genes in HK‐2 renal proximal tubular epithelial cells9
Comparative characterization of nine novel GH51, GH54 and GH62 α‐l‐arabinofuranosidases from Penicillium subrubescens9
Defective mitochondrial import as a challenge for cellular protein homeostasis8
Ergothioneine: a potential antioxidative and antimelanosis agent for food quality preservation8
New structural insights into the multifunctional influenza A matrix protein 18
Bone morphogenetic protein 9 (BMP9) directly induces Notch effector molecule Hes1 through the SMAD signaling pathway in osteoblasts8
Chiral proofreading during protein biosynthesis and its evolutionary implications8
Interorgan crosstalk mechanisms in disease: the case of acute kidney injury‐induced remote lung injury8
Are casein micelles extracellular condensates formed by liquid‐liquid phase separation?8
Human induced pluripotent stem cells for studying mitochondrial diseases in the heart8
Yeast Sec14‐like lipid transfer proteins Pdr16 and Pdr17 bind and transfer the ergosterol precursor lanosterol in addition to phosphatidylinositol8
Charged sequence motifs increase the propensity towards liquid–liquid phase separation8
The roles of molecular chaperones in regulating cell metabolism8
Membrane occupation and recognition nexus (MORN) motif controls protein localization and function8
Identification of chemical compounds regulating PD‐L1 by introducing HiBiT‐tagged cells8
Mice lacking endogenous TRPV1 express reduced levels of thermogenic proteins and are susceptible to diet‐induced obesity and metabolic dysfunction8
How to tame your genes: mechanisms of inflammatory gene repression by glucocorticoids8
Advances in structural, spatial, and temporal mechanics of plant endocytosis8
Dynamic regulation of LINC complex composition and function across tissues and contexts8
The key role of ergothioneine in label‐free surface‐enhanced Raman scattering spectra of biofluids: a retrospective re‐assessment of the literature8
Mechanisms of interorgan crosstalk in health and disease8
An update on post‐transcriptional regulation of retrotransposons8
Combinatorial pathway disruption is a powerful approach to delineate metabolic impacts of endocrine disruptors7
Dopamine and the phosphorylated dopamine transporter are increased in the diacylglycerol kinase η‐knockout mouse brain7
K+ regulates relocation of Pellino‐2 to the site of NLRP3 inflammasome activation in macrophages7
A gold revision of the Golgi Dynamics (GOLD) domain structure and associated cell functionalities7
Copper binding and reactivity at the histidine brace motif: insights from mutational analysis of the Pseudomonas fluorescens copper chaperone CopC7
Enzymatic activity of the blue light‐regulated phosphodiesterase BlrP1 from Klebsiella pneumoniae shows a nonlinear dependence on light intensity7
The 3D‐structure, kinetics and dynamics of the E. coli nitroreductase NfsA with NADP+ provide glimpses of its catalytic mechanism7
Identification of the fatty acid coenzyme‐A ligase FadD1 as an interacting partner of FptX in the Pseudomonas aeruginosa pyochelin pathway7
Choreography of lamina‐associated domains: structure meets dynamics7
The archaeal division protein CdvB1 assembles into polymers that are depolymerized by CdvC7
Disulfide bond formation and redox regulation in the Golgi apparatus7
Does Lactobacillus reuteri influence ergothioneine levels in the human body?7
The emerging landscape of eukaryotic polyphosphatases7
The role of brain innate immune response in lysosomal storage disorders: fundamental process or evolutionary side effect?7
Mamma Mia, P‐glycoprotein binds again7
Negative feedback and modern anti‐cancer strategies targeting the ER stress response7
Unique structural features of the adenylate kinase hCINAP/AK6 and its multifaceted functions in carcinogenesis and tumor progression7
Cytochrome c oxidase biogenesis – from translation to early assembly of the core subunit COX17
Bacterial Growth Inhibition Screen (BGIS): harnessing recombinant protein toxicity for rapid and unbiased interrogation of protein function7
The guanine nucleotide exchange factor FLJ00068 activates Rac1 in adipocyte insulin signaling7
The cyclin‐dependent kinase inhibitor p27Kip1 interacts with the aryl hydrocarbon receptor and negatively regulates its transcriptional activity7
Targeting the non‐ATP‐binding pocket of the MAP kinase p38γ mediates a novel mechanism of cytotoxicity in cutaneous T‐cell lymphoma (CTCL)7
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