FEBS Letters

Papers
(The TQCC of FEBS Letters is 6. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-08-01 to 2025-08-01.)
ArticleCitations
Front Cover130
Front Cover89
Molecular and mechanical mechanisms of animal cell abscission53
Cordycepin generally inhibits growth factor signal transduction in a systems pharmacology study51
Silica‐coated magnetic nanobeads in a flow enrichment target capture Halbach (FETCH) magnetic separation system for circulating tumor cell enrichment50
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Mechanisms and kinetic assays of aminoacyl‐tRNA synthetases48
Microscopic modulation and analysis of islets of Langerhans in living zebrafish larvae47
Novel insights into autophagosome biogenesis revealed by cryo‐electron tomography42
Skraban‐Deardorff intellectual disability syndrome‐associated mutations in WDR26 impair CTLH E3 complex assembly40
Insight into the function of the Golgi membrane protein GOLM1 in cholangiocytes through interactomic analysis39
Artificial miRNAs derived from miR‐181 family members have potential in cancer therapy due to an altered spectrum of target mRNAs38
CRK and NCK adaptors may functionally overlap in zebrafish neurodevelopment, as indicated by common binding partners and overlapping expression patterns38
The fatty acid synthase inhibitor C75 differentially affects the adipogenic differentiation of multipotent cells and preadipocytes37
miR‐4734 conditionally suppresses ER stress‐associated proinflammatory responses37
The ubiquitin–proteasome system and autophagy mutually interact in neurotoxin‐induced dopaminergic cell death models of Parkinson's disease36
Localization of the ubiquitin ligase Dma1 to the fission yeast contractile ring is modulated by phosphorylation36
Interdomain electron transfer in flavohaemoglobin from Candida norvegensis with antibiotic azole compounds35
Promiscuous activity of β‐carotene hydroxylase CrtZ on epoxycarotenoids leads to the formation of rare carotenoids with 6‐hydroxy‐3‐keto‐ε‐ends35
Heparin promotes rapid fibrillation of the basic parathyroid hormone at physiological pH34
Mycobacterium tuberculosis low molecular weight T‐cell antigen Mtb8.4 has heme‐binding and fiber‐forming properties34
Clinical and mechanistic insights into the roles of DDX41 in haematological malignancies33
Cytochrome bd‐I from Escherichia coli is catalytically active in the absence of the CydH subunit33
Mapping secondary substrate‐binding sites on the GH11 xylanase from Bacillus subtilis33
ArabidopsisRAN GTPases are critical for mitosis during male and female gametogenesis32
A two‐step mechanism for the binding of the HIV‐1 MPER epitope by the 10E8 antibody onto biosensor‐supported lipid bilayers31
Valosin‐containing protein regulates the stability of fused in sarcoma granules in cells by changing ATP concentrations30
Mice deficient in the phosphatase activity of sEH show decreased levels of the endocannabinoid 2‐AG in the olfactory bulb and depressive‐like behavior30
Front Cover29
Purification tags markedly affect self‐aggregation of CPEB329
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Presenting the FEBS Letters virtual issue on vesicle biology28
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Front Cover27
Structural and functional insights of itaconyl‐CoA hydratase from Pseudomonas aeruginosa highlight a novel N‐terminal hotdog fold26
Siderophore specificities of the Pseudomonas aeruginosa TonB‐dependent transporters ChtA and ActA26
Generation of novel anti‐apoE monoclonal antibodies that selectively recognize apoE isoforms26
Homocysteine thiolactone and H2O2 induce amino acid modifications and alter the fibrillation propensity of the Aβ25–35 peptide25
PAT mRNA decapping factors are required for proper development in Arabidopsis25
A novel approach to single‐cell analysis reveals intrinsic differences in immune marker expression in unstimulated BALB/c and C57BL/6 macrophages25
Reactivity of γ‐glutamyl‐cysteine with intracellular and extracellular glutathione metabolic enzymes25
Intron‐oriented HTLV‐1 integration in an adult T‐cell leukemia/lymphoma cell line sustains expression of intact ift81mRNA25
The 19S proteasome subunit Rpt5 reversibly associates with cold‐stable microtubules in glial cells at low temperatures25
Interorgan crosstalk mechanisms in disease: the case of acute kidney injury‐induced remote lung injury25
Mechanisms of interorgan crosstalk in health and disease25
Human phytanoyl‐CoA dioxygenase domain‐containing 1 (PHYHD1) is a putative oxygen sensor associated with RNA and carbohydrate metabolism25
Site‐specific functional roles of the Factor X activation peptide in the intrinsic tenase‐mediated Factor X activation24
Elucidation of interface interactions between a dehydratase domain and an acyl carrier protein in cremimycin polyketide synthase24
MyD88 and not TRIF knockout is sufficient to abolish LPS‐induced inflammatory responses in bone‐derived macrophages24
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Retraction statement: miR‐518b is down‐regulated, and involved in cell proliferation and invasion by targeting Rap1b in esophageal squamous cell carcinoma.24
Fluorescence‐based CRISPR interference system for controlled genetic repression and live single‐cell imaging in mycobacteria23
Solving the protein folding problem…23
Cas9‐Geminin and Cdt1‐fused anti‐CRISPR protein synergistically increase editing accuracy23
RANBP2 evolution and human disease22
Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia22
Unlocking the biochemical secrets of longevity: balancing healthspan and lifespan22
Small GTPase signaling hubs at the surface of cellular membranes in physiology and disease21
Front Cover21
Why science education is more important than most scientists think21
Front Cover21
Gly56 in the synthetic site of isoleucyl‐tRNA synthetase confers specificity and maintains communication with the editing site20
A highly active S1‐P1 nuclease from the opportunistic pathogen Stenotrophomonas maltophilia cleaves c‐di‐GMP20
Membrane occupation and recognition nexus (MORN) motif controls protein localization and function20
A novel perspective on the role of nucleus accumbens neurons in encoding associative learning20
STAT3 transcriptionally regulates the expression of genes related to glycogen metabolism in developing motor neurons20
Structural basis for substrate and antibiotic recognition by Helicobacter pylori isoleucyl‐tRNA synthetase19
Molecular determinants of lipid droplet subpopulations and their fates19
THAP3 recruits SMYD3 to OXPHOS genes and epigenetically promotes mitochondrial respiration in hepatocellular carcinoma19
Neuronostatin regulates proliferation and differentiation of rat brown primary preadipocytes18
Does the nuclear envelope retain its identity during mitosis?18
Disrupting the interaction between a p53 gain‐of‐function mutant and the transcriptional co‐activator PC4 reverses drug resistance in cancer cells18
The BcsD subunit of type I bacterial cellulose synthase interacts dynamically with the BcsAB catalytic core complex18
The S‐adenosylmethionine analog sinefungin inhibits the trimethylguanosine synthase TGS1 to promote telomerase activity and telomere lengthening18
Coordinating nucleoporin condensation and nuclear pore complex assembly18
Characterizing the amino acid activation center of the naturally editing‐deficient aminoacyl‐tRNA synthetase PheRS in Mycoplasma mobile18
Distinct dysregulated pathways in sporadic and Lynch syndrome‐associated colorectal cancer offer insights for targeted treatment17
It's a two‐way street: Photoswitching and reversible changes of the protein matrix in photoswitchable fluorescent proteins and bacteriophytochromes17
The enigmatic world of tear extracellular vesicles (EVs)–exploring their role in ocular health and beyond17
Social context prevents heat hormetic effects against mutagens during fish development16
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SARSCoV‐2‐derived protein Orf9b enhances MARK2 activity via interaction with the autoinhibitory KA1 domain16
Front Cover16
Membranes that make fat: roles of membrane lipids as acyl donors for triglyceride synthesis and organelle function16
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Heteromerization between α1B‐adrenoceptor and chemokine (C‐C motif) receptor 2 biases α1B‐adrenoceptor signaling: Implications for vascular funct15
The role of Lin28A and Lin28B in cancer beyond Let‐715
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The solution supramolecular structure of α2 → 8 polysialic acid suggests a structural cause for its low immunogenicity15
An updated classification and mechanistic insights into ligand binding of the substrate‐binding proteins15
A scorpion toxin affecting sodium channels shows double cistrans isomerism15
Front Cover15
Front Cover15
AKT controls NLRP3 inflammasome activation by inducing DDX3X phosphorylation15
Transcription‐coupled DNA repair protects genome stability upon oxidative stress‐derived DNA strand breaks15
Fanzors, a family of eukaryotic RNA‐guided DNA endonucleases15
The age‐related decline of helicase function—how G‐quadruplex structures promote genome instability15
The Melolontha melolontha entomopoxvirus fusolin protein is a chitin‐active lytic polysaccharide monooxygenase that displays extreme stability15
Front Cover15
Structural differences in the outer membrane‐associated flagellar rings between sheathed and unsheathed flagella15
Crystal structure of a novel heterooligomeric aminotransferase from Serratia sp. ATCC 39006 provides insights into function14
Predicting genome‐wide tissue‐specific enhancers via combinatorial transcription factor genomic occupancy analysis14
A coiled‐coil domain triggers oligomerization of MmpL10, the mycobacterial transporter of trehalose polyphleate precursor14
Deacylases—structure, function, and relationship to diseases14
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Retraction Statement: miR‐188 promotes senescence of lineage‐negative bone marrow cells by targeting MAP3K3 expression14
Ablation of LRP6 in alpha‐smooth muscle actin‐expressing cells abrogates lung inflammation and fibrosis upon bleomycin‐induced lung injury14
Front Cover14
Endothelial lipase‐binding peptides similar to netrin‐1 inhibit hepatitis B virus infection14
Glutamate dehydrogenase enables Salmonella to survive under oxidative stress and escape from clearance in macrophages14
Bioinspired and biomolecular catalysts for energy conversion and storage13
Acetylation stabilises calmodulin‐regulated calcium signalling13
The roles of molecular chaperones in regulating cell metabolism13
From the sideline: Tissue‐specific nucleoporin function in health and disease, an update13
GENIGMA: an app to map the 3D genome of cancer cell lines through extreme citizen science13
Middle East respiratory syndrome coronavirus ORF4b protein inhibits TLR7‐ and TLR9‐dependent alpha interferon induction13
Photosystems and photoreceptors in cyanobacterial phototaxis and photophobotaxis13
Senile plaques in Alzheimer's disease arise from Aβ‐ and Cathepsin D‐enriched mixtures leaking out during intravascular haemolysis and microaneurysm rupture13
GCN2 kinase‐mediated upregulation of ubiquitin C maintains intracellular glutamine level and tRNAGln(CUG) charging under amino acid starvation13
Tumour suppressor p53 inhibits hepatitis C virus replication by inducing E6AP‐mediated proteasomal degradation of the viral core protein13
Abiogenesis through gradual evolution of autocatalysis into template‐based replication13
MiR‐15b‐5p inhibits castration‐resistant growth of prostate cancer cells by targeting the muscarinic cholinergic receptor CHRM313
Unorthodox regulation of the MglA Ras‐like GTPase controlling polarity in Myxococcus xanthus13
ATG and ESCRT control multiple modes of microautophagy12
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The anabolic steroid stanozolol is a potent inhibitor of human MutT homolog 112
Engineering ergothioneine production in Yarrowia lipolytica12
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Targeting RNA‐binding proteins with small molecules: Perspectives, pitfalls and bifunctional molecules12
Interferon‐induced protein ISG15 in the central nervous system, quo vadis?12
The 3D‐structure, kinetics and dynamics of the E. coli nitroreductase NfsA with NADP+ provide glimpses of its catalytic mechanism12
Retraction statement: MicroRNA‐520g induces epithelial‐mesenchymal transition and promotes metastasis of hepatocellular carcinoma by targeting SMAD712
Lipid droplets and fatty acid‐induced lipotoxicity: in a nutshell12
Front Cover11
The Saccharomyces cerevisiae amino acid transporter Lyp1 has a broad substrate spectrum11
Autophagy in cancer and protein conformational disorders11
Structural and functional insights into the enzymatic activities of lipases from Burkholderia stagnalis and Burkholderia plantarii11
Hypoxanthine‐guanine phosphoribosyltransferase is activated via positive cooperativity between guanine and IMP11
Krüppel‐like factor 6 participates in extravillous trophoblast cell differentiation and its expression is reduced in abnormally invasive placenta11
Endocytic proteins mediating GPR15 receptor internalization provide insight into the underlying mechanisms11
Odz4 upregulates SAN‐specific genes to promote differentiation into cardiac pacemaker‐like cells11
Charged sequence motifs increase the propensity towards liquid–liquid phase separation11
Protonophore activity of short‐chain fatty acids induces their intracellular accumulation and acidification11
STAP‐2 negatively regulates BCR‐mediated B cell activation by recruiting tyrosine‐protein kinase CSK to LYN11
Sticholysin I–II oligomerization in the absence of membranes11
Integrin β1 transduces the signal for LY6D‐induced macropinocytosis and mediates senescence‐inducing stress‐evoked vacuole formation via FAK11
GABARAP interacts with EGFR — supporting the unique role of this hAtg8 protein during receptor trafficking11
Mobile zinc as a modulator of sensory perception11
The survival grip–how cell adhesion promotes tumor maintenance within the microenvironment11
Yeast Sec14‐like lipid transfer proteins Pdr16 and Pdr17 bind and transfer the ergosterol precursor lanosterol in addition to phosphatidylinositol11
The mechanics of the heart: zooming in on hypertrophic cardiomyopathy and cMyBP‐C11
The clinically relevant triple mutation in the mtND1 gene inactivates Escherichia coli complex I11
Autophagy as a caretaker of nuclear integrity11
Release of FUS into the extracellular space is regulated by its amino‐terminal prion‐like domain11
Molecular characterization of a moss isoprene synthase provides insight into its evolution10
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A nanoemulsified formulation of dolutegravir and epigallocatechin gallate inhibits HIV‐1 replication in cellular models10
Human WIPI β‐propeller function in autophagy and neurodegeneration10
The orf virus (ORFV) protein OV20.0 interacts with the microprocessor complex subunit DGCR8 to regulate miRNA biogenesis and ORFV infection10
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Temperature adaptation of yeast phospholipid molecular species at the acyl chain positional level10
Autophagy in a Nutshell10
Cis‐regulatory evolution underlying the changes in wingless expression pattern associated with wing pigmentation of Drosophila10
Amy and Friends: improving the lives of individuals affected by DNA repair disorders10
Lipocalin 2 inhibits actin glutathionylation to promote invasion and migration10
Front Cover9
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EXPRESSION OF CONCERN: Introgression of a Novel Salt‐Tolerant L‐Myo‐Inositol 1‐Phosphate Synthase from Porteresia Coarctata (Roxb.) Tateoka (PcINO1) Confers Salt Tolera9
Succinate oxidation rescues mitochondrial ATP synthesis at high temperature in Drosophila melanogaster9
F‐actin determines the time‐dependent shift in docking dynamics of glucagon‐like peptide‐1 granules upon stimulation of secretion9
Nucleocytoplasmic transport at the crossroads of proteostasis, neurodegeneration and neuroprotection9
Front Cover9
Front Cover9
A new approach to making scientific research more efficient – rethinking sustainability9
Clinically observed deletions in SARS‐CoV‐2 Nsp1 affect its stability and ability to inhibit translation9
The deubiquitinase USP10 mediates crosstalk between the LKB1/AMPK axis and Wnt/β‐catenin signaling in cancer9
Thiol redox switches regulate the oligomeric state of cyanobacterial Rre1, RpaA and RpaB response regulators9
The dual nature of TDC – bridging dendritic and T cells in immunity9
Clues to transcription/replication collision‐induced DNA damage: it was RNAP, in the chromosome, with the fork9
Mitochondrial permeability transition mediated by MTCH2 and F‐ATP synthase contributes to ferroptosis defense9
The prolyl hydroxylase OGFOD1 promotes cancer cell proliferation by regulating the expression of cell cycle regulators9
Structural determinants for membrane binding of the EGFR juxtamembrane domain9
Nuclear pore complex and nucleocytoplasmic transport disruption in neurodegeneration9
Overactivation of the androgen receptor exacerbates gravid uterine ferroptosis via interaction with and suppression of the NRF2 defense signaling pathway9
Deletion of the transcription factors Hsf1, Msn2 and Msn4 in yeast uncovers transcriptional reprogramming in response to proteotoxic stress9
The winner of the 2024 FEBS Letters Award—an interview with Rachel Flynn9
Front Cover8
Evidence for partial functional overlap of KEA and MSL transport proteins in the chloroplast inner envelope of Arabidopsis thaliana8
Front Cover8
The FEBS 60th anniversary writing contest—blueprints for the scientific society of tomorrow8
The structure of a Lactobacillus helveticus chlorogenic acid esterase and the dynamics of its insertion domain provide insights into substrate binding8
Comparative characterization of nine novel GH51, GH54 and GH62 α‐l‐arabinofuranosidases from Penicillium subrubescens8
Transcription as a double‐edged sword in genome maintenance8
The scorpion toxin BeKm‐1 blocks hERG cardiac potassium channels using an indispensable arginine residue8
The radical impact of oxygen on prokaryotic evolution—enzyme inhibition first, uninhibited essential biosyntheses second, aerobic respiration third8
Divergent effects of cholesterol on the structure and fluidity of liposome and catanionic vesicle membranes8
Knockout of the BRAP homolog in mice leads to abnormal tracheal cilia8
Corrigendum8
RETRACTION: Theaflavins Retard Human Breast Cancer Cell Migration by Inhibiting NF‐κB via p53‐ROS Cross‐talk8
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The chromatin repressors EZH2 and Suv4‐20h coregulate cell fate specification during hippocampal development8
EZH2 modulates retinoic acid signaling to ensure myotube formation during development8
Decline of ergothioneine in frailty and cognition impairment8
A γ‐glutamyl hydrolase lacking the signal peptide confers susceptibility to folates/antifolates in acute lymphoblastic leukemia cells8
Quinone chemistry in respiratory complex I involves protonation of a conserved aspartic acid residue8
Distinct classes of misfolded proteins differentially affect the growth of yeast compromised for proteasome function8
Dissecting the Ca2+ dependence of DesA1 function in Mycobacterium tuberculosis8
Single‐dose immunisation with a multimerised SARS‐CoV‐2 receptor binding domain (RBD) induces an enhanced and protective response in mice8
Conjugative transfer of the IncN plasmid pKM101 is mediated by dynamic interactions between the TraK accessory factor and TraI8
LIM protein Ajuba promotes liver cell proliferation through its involvement in DNA replication and DNA damage control8
Blueprints for the scientific society of the future: how FEBS and other scientific societies will have changed 60 years from now8
Front Cover8
A single evolutionarily divergent mutation determines the different FAD‐binding affinities of human and rat NQO1 due to site‐specific phosphorylation8
Two phosphoenolpyruvate carboxykinases with differing biochemical properties in Chlamydomonas reinhardtii8
ABC transporter activity is affected by the size of lipid nanodiscs8
You are who your friends are—nuclear pore proteins as components of chromatin‐binding complexes8
HNF4α overexpression enhances the therapeutic potential of umbilical cord mesenchymal stem/stromal cells in mice with acute liver failure8
Urinary microRNA profiling in pregnant women identifies placental microRNAs that are candidate biomarkers for monitoring placental health8
Hidden biochemical fossils reveal an evolutionary trajectory for glycolysis in the prebiotic era8
Strigolactone biosynthesis in rice can occur via a 9‐cis‐3‐OH‐10′‐apo‐β‐carotenal intermediate8
Activation of the purinergic receptor P2X7 improves hepatosteatosis by promoting lipophagy8
'The world needs science, and science needs women'…but what do women in science need? – interviews and panel discussion with 5 outstanding female scientists7
Structural basis for the minimal bifunctional alginate epimerase AlgE3 from Azotobacter chroococcum7
Circulating histones as clinical biomarkers in critically ill conditions7
Deubiquitinases at the interplay between hematopoietic stem cell aging and myelodysplastic transformation7
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Poliovirus capsid protein VP3 can penetrate vascular endothelial cells7
Small RNA sequencing in hypoxic naked mole‐rat hearts suggests microRNA regulation of RNA‐ and translation‐related processes7
Atomic structure of the regulatory TGS domain of Rel protein from Mycobacterium tuberculosis and its interaction with deacylated tRNA7
Two years into COVID‐19 – Lessons in SARS‐CoV‐2 and a perspective from papers in FEBS Letters7
Neurospora casein kinase 1a recruits the circadian clock protein FRQvia the C‐terminal lobe of its kinase domain7
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Endomembrane‐mediated storage protein trafficking in plants: Golgi‐dependent or Golgi‐independent?7
The activator/repressor Hap1 binds to the yeast eIF5A‐encoding gene TIF51A to adapt its expression to the mitochondrial functional status7
K+ regulates relocation of Pellino‐2 to the site of NLRP3 inflammasome activation in macrophages7
l‐2‐Aminopimelic acid acts as an auxin mimic to induce lateral root formation across diverse plant species7
A Pellino‐2 variant is associated with constitutive NLRP3 inflammasome activation in a family with ocular pterygium–digital keloid dysplasia7
A guide for blood–brain barrier models7
Front Cover7
Transforming science communication through storytelling7
Transcription factor EB controls both motogenic and mitogenic cell activities7
Adding hydrophobicity or positive charges to the cytosolic half of the α‐synuclein 3–11 helix increases membrane association and S129 phosphorylation7
A purine and a backbone discontinuous site alter the structure and thermal stability of DNA minidumbbells containing two pentaloops7
A life‐time of hematopoietic cell function: ascent, stability, and decline7
Roles of methionine and cysteine residues of the Escherichia coli sensor kinase HprS in reactive chlorine species sensing7
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