FEBS Letters

Article	Citations
Mitochondrial DNA copy number in human disease: the more the better?	251
Mitochondrial dynamics in health and disease	156
Enhanced binding of the N501Y‐mutated SARS‐CoV‐2 spike protein to the human ACE2 receptor: insights from molecular dynamics simulations	155
Mitochondrial disorders of the OXPHOS system	142
G Protein‐Coupled receptors and heterotrimeric G proteins as cancer drivers	93
Mitochondria, energy, and metabolism in neuronal health and disease	77
Mitochondrial protein import dysfunction: mitochondrial disease, neurodegenerative disease and cancer	61
Extracellular vesicles and intercellular communication in the central nervous system	60
The raw truth about paper mills	55
Lipopolysaccharide and the gut microbiota: considering structural variation	53
The Diseased Mitoribosome	51
MICOS and the mitochondrial inner membrane morphology – when things get out of shape	50
Transcription factors and ABC transporters: from pleiotropic drug resistance to cellular signaling in yeast	43
Sphingolipids in plants: a guidebook on their function in membrane architecture, cellular processes, and environmental or developmental responses	42
Sharing biological data: why, when, and how	39
The ergothioneine transporter (ETT): substrates and locations, an inventory	38
Fibroblast‐mediated intercellular crosstalk in the healthy and diseased heart	37
The role of the degenerate nucleotide binding site in type I ABC exporters	37
Munc13 binds and recruits SNAP25 to chaperone SNARE complex assembly	36
Structures of ABC transporters: handle with care	34
The cross‐talk between Abl2 tyrosine kinase and TGFβ1 signalling modulates the invasion of clear cell Renal Cell Carcinoma cells	34
The circadian clock and diseases of the skin	34
Genetic basis of mitochondrial diseases	33
An inventory of lysosomal ABC transporters	32
Resveratrol reduces cardiac NLRP3‐inflammasome activation and systemic inflammation to lessen doxorubicin‐induced cardiotoxicity in juvenile mice	32

The degree of unsaturation of fatty acids in phosphatidylserine alters the rate of insulin aggregation and the structure and toxicity of amyloid aggregates	32
Mitochondrial clearance: mechanisms and roles in cellular fitness	31
Evolutionary history of ATP‐binding cassette proteins	31
The molecular pathology of pathogenic mitochondrial tRNA variants	31
Aggregation and mobility of membrane proteins interplay with local lipid order in the plasma membrane of T cells	31
Small RNAs in epigenetic inheritance: from mechanisms to trait transmission	31
LRRK2 phosphorylation of Rab GTPases in Parkinson's disease	30
The impact of reductants on the catalytic efficiency of a lytic polysaccharide monooxygenase and the special role of dehydroascorbic acid	30
Transposable elements as new players in neurodegenerative diseases	30
A Hitchhiker's guide through the bio‐image analysis software universe	30
ABCB1/MDR1/P‐gp employs an ATP‐dependent twist‐and‐squeeze mechanism to export hydrophobic drugs	28
Single‐dose immunisation with a multimerised SARS‐CoV‐2 receptor binding domain (RBD) induces an enhanced and protective response in mice	28
Genome‐wide analysis and transcriptional regulation of the typical and atypical thioredoxins in Arabidopsis thaliana	27
ABC‐F translation factors: from antibiotic resistance to immune response	27
Health consequences of improving the content of ergothioneine in the food supply	26
The proteasome: friend and foe of mitochondrial biogenesis	26
The role of exosomes in intercellular and inter‐organ communication of the peripheral nervous system	26
Tubulin mutations in neurodevelopmental disorders as a tool to decipher microtubule function	26
Neuronatin promotes SERCA uncoupling and its expression is altered in skeletal muscles of high‐fat diet‐fed mice	25
Autophagy in plant viral infection	25
Mitochondrial proteases in human diseases	25
Expanding role of PI5P4Ks in cancer: A promising druggable target	24
ASC‐1 transporter‐dependent amino acid uptake is required for the efficient thermogenic response of human adipocytes to adrenergic stimulation	24
Looking back at multidrug resistance (MDR) research and ten mistakes to be avoided when writing about ABC transporters in MDR	24
Sphingolipid‐enriched domains in fungi	23
α‐Synuclein phase separation and amyloid aggregation are modulated by C‐terminal truncations	22
AP‐1 and NF‐κB synergize to transcriptionally activate latent HIV upon T‐cell receptor activation	22
Mass spectrometry‐based abundance atlas of ABC transporters in human liver, gut, kidney, brain and skin	22
Pseudouridines in RNAs: switching atoms means shifting paradigms	22
Interface‐based design of the favipiravir‐binding site in SARS‐CoV‐2 RNA‐dependent RNA polymerase reveals mutations conferring resistance to chain termination	22
Cryo‐EM of ABC transporters: an ice‐cold solution to everything?	21
Diet‐derived ergothioneine induces necroptosis in colorectal cancer cells by activating the SIRT3/MLKL pathway	21
Bioinorganic supramolecular coordination complexes and their biomedical applications	21
The Saccharomyces cerevisiae ABC subfamily D transporter Pxa1/Pxa2p co‐imports CoASH into the peroxisome	21
Fluorescence CLEM in biology: historic developments and current super‐resolution applications	21
CAR‐Ts: new perspectives in cancer therapy	21
Glycans as a key factor in self and nonself discrimination: impact on the breach of immune tolerance	20
Serum levels of the IgA isotype switch factor TGF‐β1 are elevated in patients with COVID‐19	20
Why do pathway methods work better than they should?	20
Local and systemic effects of interleukin‐6 (IL‐6) in inflammation and cancer	19
Matching chemical properties to molecular biological activities opens a new perspective on l‐ergothioneine	19
A weak COPI binding motif in the cytoplasmic tail of SARS‐CoV‐2 spike glycoprotein is necessary for its cleavage, glycosylation, and localization	18
The complex roles of autophagy in plant immunity	18
Biological nitrogen fixation in theory, practice, and reality: a perspective on the molybdenum nitrogenase system	18
The mechanics of the heart: zooming in on hypertrophic cardiomyopathy and cMyBP‐C	18
Annexins A1 and A2 are recruited to larger lysosomal injuries independently of ESCRTs to promote repair	18
Exocyst functions in plants: secretion and autophagy	18
SARS‐CoV‐2 nucleocapsid protein interacts with immunoregulators and stress granules and phase separates to form liquid droplets	18
Protein metalation in a nutshell	17
New mechanistic insights into coupled binuclear copper monooxygenases from the recent elucidation of the ternary intermediate of tyrosinase	17

Water oxidation in oxygenic photosynthesis studied by magnetic resonance techniques	17
Plant cytokinesis and the construction of new cell wall	17
The structure of COPI vesicles and regulation of vesicle turnover	17
Ergothioneine in the brain	17
An updated classification and mechanistic insights into ligand binding of the substrate‐binding proteins	17
The chromatin modifier MORC2 affects glucose metabolism by regulating the expression of lactate dehydrogenase A through a feed forward loop with c‐Myc	16
Ablation of fatty acid desaturase 2 (FADS2) exacerbates hepatic triacylglycerol and cholesterol accumulation in polyunsaturated fatty acid‐depleted mice	16
Identification of two subtilisin‐like serine proteases engaged in the degradation of recombinant proteins in Nicotiana benthamiana	16
Decline of ergothioneine in frailty and cognition impairment	16
Metabolism and autophagy in plants—a perfect match	16
A twist in the ABC: regulation of ABC transporter trafficking and transport by FK506‐binding proteins	16
The histidine brace: nature's copper alternative to haem?	16
Conformational changes in the nucleotide‐binding domains of P‐glycoprotein induced by ATP hydrolysis	16
Calcium transfer between endoplasmic reticulum and mitochondria in liver diseases	16
Siglec‐15 promotes the migration of liver cancer cells by repressing lysosomal degradation of CD44	16
Reductants fuel lytic polysaccharide monooxygenase activity in a pH‐dependent manner	16
The splicing regulatory factor hnRNPU is a novel transcriptional target of c‐Myc in hepatocellular carcinoma	15
The small GTPase Sar1, control centre of COPII trafficking	15
Plant endosomes as protein sorting hubs	15
Cardiolipin deficiency in Barth syndrome is not associated with increased superoxide/H2O2 production in heart and skeletal muscle mitochondria	15
Soluble forms of cytokine and growth factor receptors: mechanisms of generation and modes of action in the regulation of local and systemic inflammation	15
The coordinated action of glucuronoyl esterase and α‐glucuronidase promotes the disassembly of lignin–carbohydrate complexes	15
AKT controls NLRP3 inflammasome activation by inducing DDX3X phosphorylation	15
Mitochondrial [2Fe‐2S] ferredoxins: new functions for old dogs	15
CircRNAs in gastric cancer: current research and potential clinical implications	15
Neurological pathophysiology of SARS‐CoV‐2 and pandemic potential RNA viruses: a comparative analysis	15
The Microglial membrane receptor TREM2 mediates exosome secretion to promote phagocytosis of amyloid‐β by microglia	15
Genome‐scale metabolic modelling of SARS‐CoV‐2 in cancer cells reveals an increased shift to glycolytic energy production	15
Disruption of small molecule transporter systems by Transporter‐Interfering Chemicals (TICs)	14
ER‐to‐lysosome‐associated degradation in a nutshell: mammalian, yeast, and plant ER‐phagy as induced by misfolded proteins	14
Vesicle capture by membrane‐bound Munc13‐1 requires self‐assembly into discrete clusters	14
Human fibroblast‐derived extracellular vesicles promote hair growth in cultured human hair follicles	14
The sphingolipid anteome: implications for evolution of the sphingolipid metabolic pathway	14
RhoA regulation in space and time	14
Engineering ergothioneine production in Yarrowia lipolytica	14
Chemical effects on dye efflux activity in live zebrafish embryos and on zebrafish Abcb4 ATPase activity	14
Galectin‐1–RNA interaction map reveals potential regulatory roles in angiogenesis	14
Porphyromonas gingivalis enhances pneumococcal adhesion to human alveolar epithelial cells by increasing expression of host platelet‐activating factor receptor	14
The SLIM1 transcription factor is required for arsenic resistance in Arabidopsis thaliana	14
Ergothioneine, where are we now?	13
Fatty acid‐binding protein 5 controls lung tumor metastasis by regulating the maturation of natural killer cells in the lung	13
Acetate overflow metabolism regulates a major metabolic shift after glucose depletion in Escherichia coli	13
Human SND2 mediates ER targeting of GPI‐anchored proteins with low hydrophobic GPI attachment signals	13
Capturing the sequence of events during the water oxidation reaction in photosynthesis using XFELs	13
Dynamin‐related protein 1 positively regulates osteoclast differentiation and bone loss	13
Proline‐rich extensin‐like receptor kinases PERK5 and PERK12 are involved in pollen tube growth	13
Why science education is more important than most scientists think	13
Gene network analysis using SWIM reveals interplay between the transcription factor‐encoding genes HMGA1, FOXM1, and MYBL2 in triple‐negative breast cancer	12
The Arabidopsis thaliana mRNA decay factor PAT1 functions in osmotic stress responses and decaps ABA‐responsive genes	12
The RNA demethylase ALKBH5 promotes osteoblast differentiation by modulating Runx2 mRNA stability	12
Interactions between autophagy and phytohormone signaling pathways in plants	12
The involvement of sodium in the function of the human amino acid transporter ASCT2	12
Periostin deficiency attenuates lipopolysaccharide‐ and obesity‐induced adipose tissue fibrosis	12
SUMO in the regulation of DNA repair and transcription at nuclear pores	12
Protein translocation in mitochondria: Sorting out the Toms, Tims, Pams, Sams and Mia	12
Radical SAM enzymes: Nature's choice for radical reactions	12
COPII vesicles in plant autophagy and endomembrane trafficking	12
Single‐molecule studies of conformational states and dynamics in the ABC importer OpuA	12
Strategies for cystic fibrosis transmembrane conductance regulator inhibition: from molecular mechanisms to treatment for secretory diarrhoeas	12
From membrane to mineralization: the curious case of the ABCC6 transporter	11
Long noncoding RNAs in cardiometabolic disorders	11
The bridge helix of Cas12a imparts selectivity in cis‐DNA cleavage and regulates trans‐DNA cleavage	11
Senile plaques in Alzheimer's disease arise from Aβ‐ and Cathepsin D‐enriched mixtures leaking out during intravascular haemolysis and microaneurysm rupture	11
NRG/ErbB signaling regulates neonatal muscle growth but not neuromuscular contractures in neonatal brachial plexus injury	11
Different recognition modes of G‐quadruplex RNA between two ALS/FTLD‐linked proteins TDP‐43 and FUS	11
From in vitro towards in situ: structure‐based investigation of ABC exporters by electron paramagnetic resonance spectroscopy	11
Chloroplastic ascorbate peroxidases targeted to stroma or thylakoid membrane: The chicken or egg dilemma	11
Cardiolipin prevents pore formation in phosphatidylglycerol bacterial membrane models	11
Meprin and ADAM proteases as triggers of systemic inflammation in sepsis	11
An excess of glycolytic enzymes under glucose‐limited conditions may enable Saccharomyces cerevisiae to adapt to nutrient availability	11
Interorgan crosstalk in pancreatic islet function and pathology	11
RAS nanoclusters are cell surface transducers that convert extracellular stimuli to intracellular signalling	11
Making sense of IL‐6 signalling cues in pathophysiology	11
Novel and conventional inhibitors of canonical autophagy differently affect LC3‐associated phagocytosis	11
Umbilical cord mesenchymal stem cell‐derived exosomes alleviate collagen‐induced arthritis by balancing the population of Th17 and regulatory T cells	11
On the role of ubiquinone in the proton translocation mechanism of respiratory complex I	10
Vesicle trafficking in Arabidopsis pollen tubes	10
Maintenance of small molecule redox homeostasis in mitochondria	10
Sterol uptake by the NPC system in eukaryotes: a Saccharomyces cerevisiae perspective	10
The mitochondrial regulator PGC1α is induced by cGMP–PKG signaling and mediates the protective effects of phosphodiesterase 5 inhibition in heart failure	10

Roles of peripheral clocks: lessons from the fly	10
Cryo‐EM structure of the full‐length Lon protease from Thermus thermophilus	10
Plant type I metacaspases are proteolytically active proteases despite their hydrophobic nature	10
ADP‐heptose enables Helicobacter pylori to exploit macrophages as a survival niche by suppressing antigen‐presenting HLA‐II expression	10
The TRAPP complexes: oligomeric exchange factors that activate the small GTPases Rab1 and Rab11	10
Defining the architecture of the human TIM22 complex by chemical crosslinking	10
Overexpression of UCP3 decreases mitochondrial efficiency in mouse skeletal muscle in vivo	10
DrosophilaTNF/TNFRs: At the crossroad between metabolism, immunity, and tissue homeostasis	10
A glycosaminoglycan microarray identifies the binding of SARS‐CoV‐2 spike protein to chondroitin sulfate E	10
Structural features of the plant N‐recognin ClpS1 and sequence determinants in its targets that govern substrate selection	10
ABIN1 is a signal‐induced autophagy receptor that attenuates NF‐κB activation by recognizing linear ubiquitin chains	10
Cytosolic PINK1 orchestrates protein translation during proteasomal stress by phosphorylating the translation elongation factor eEF1A1	10
Membrane contact sites and cytoskeleton‐membrane interactions in autophagy	10
The therapeutic capacity of bone marrow MSC‐derived extracellular vesicles in Achilles tendon healing is passage‐dependent and indicated by specific glycans	10
SARS‐CoV‐2 spike protein aggregation is triggered by bacterial lipopolysaccharide	10
Membrane trafficking functions of the ANTH/ENTH/VHS domain‐containing proteins in plants	9
Phosphorylation of NANOG by casein kinase I regulates embryonic stem cell self‐renewal	9
Turbocharging synaptic transmission	9
Generation of fully functional fluorescent fusion proteins to gain insights into ABCC6 biology	9
Heparin promotes rapid fibrillation of the basic parathyroid hormone at physiological pH	9
Multiorgan microphysiological systems as tools to interrogate interorgan crosstalk and complex diseases	9
Cargo receptors and adaptors for selective autophagy in plant cells	9
Structural biology of DOCK‐family guanine nucleotide exchange factors	9
Abiogenesis through gradual evolution of autocatalysis into template‐based replication	9
Plasmodium falciparum HSP40 protein eCiJp traffics to the erythrocyte cytoskeleton and interacts with the human HSP70 chaperone HSPA1	9
Endothelial cell autophagy in homeostasis and cancer	9
Global analysis of RNA–protein interactions in TNF‐α induced alternative splicing in metabolic disorders	9
ABRO1 stabilizes the deubiquitinase BRCC3 through inhibiting its degradation mediated by the E3 ubiquitin ligase WWP2	9
Scaffold, mechanics and functions of nuclear lamins	9
Lysophosphatidylcholine disrupts cell adhesion and induces anoikis in hepatocytes	9
Host–microbiome interactions in nicotinamide mononucleotide (NMN) deamidation	9
Astrocytic d‐amino acid oxidase degrades d‐serine in the hindbrain	9
Dynamics and electrostatics define an allosteric druggable site within the receptor‐binding domain of SARS‐CoV‐2 spike protein	9
PARP1–RNA interaction analysis: PARP1 regulates the expression of extracellular matrix‐related genes in HK‐2 renal proximal tubular epithelial cells	9
Comparative characterization of nine novel GH51, GH54 and GH62 α‐l‐arabinofuranosidases from Penicillium subrubescens	9
Osteocalcin and the physiology of danger	9
Defective mitochondrial import as a challenge for cellular protein homeostasis	8
Ergothioneine: a potential antioxidative and antimelanosis agent for food quality preservation	8
Charged sequence motifs increase the propensity towards liquid–liquid phase separation	8
The roles of molecular chaperones in regulating cell metabolism	8
Membrane occupation and recognition nexus (MORN) motif controls protein localization and function	8
Interorgan crosstalk mechanisms in disease: the case of acute kidney injury‐induced remote lung injury	8
Are casein micelles extracellular condensates formed by liquid‐liquid phase separation?	8
Human induced pluripotent stem cells for studying mitochondrial diseases in the heart	8
Yeast Sec14‐like lipid transfer proteins Pdr16 and Pdr17 bind and transfer the ergosterol precursor lanosterol in addition to phosphatidylinositol	8
New structural insights into the multifunctional influenza A matrix protein 1	8
Bone morphogenetic protein 9 (BMP9) directly induces Notch effector molecule Hes1 through the SMAD signaling pathway in osteoblasts	8
The key role of ergothioneine in label‐free surface‐enhanced Raman scattering spectra of biofluids: a retrospective re‐assessment of the literature	8
Identification of chemical compounds regulating PD‐L1 by introducing HiBiT‐tagged cells	8
Mice lacking endogenous TRPV1 express reduced levels of thermogenic proteins and are susceptible to diet‐induced obesity and metabolic dysfunction	8
How to tame your genes: mechanisms of inflammatory gene repression by glucocorticoids	8
Advances in structural, spatial, and temporal mechanics of plant endocytosis	8
Dynamic regulation of LINC complex composition and function across tissues and contexts	8
Chiral proofreading during protein biosynthesis and its evolutionary implications	8
Mechanisms of interorgan crosstalk in health and disease	8
An update on post‐transcriptional regulation of retrotransposons	8
Choreography of lamina‐associated domains: structure meets dynamics	7
Bacterial Growth Inhibition Screen (BGIS): harnessing recombinant protein toxicity for rapid and unbiased interrogation of protein function	7
A gold revision of the Golgi Dynamics (GOLD) domain structure and associated cell functionalities	7
Transcription factor SOX2 contributes to nonalcoholic fatty liver disease development by regulating the expression of the fatty acid transporter CD36	7
The SAC1 phosphatase domain of synaptojanin‐1 is activated by interacting with polyunsaturated fatty acid‐containing phosphatidic acids	7
The [2Fe‐2S] protein CISD2 plays a key role in preventing iron accumulation in cardiomyocytes	7
Polyoxovanadates as new P‐glycoprotein inhibitors: insights into the mechanism of inhibition	7
The 3D‐structure, kinetics and dynamics of the E. coli nitroreductase NfsA with NADP+ provide glimpses of its catalytic mechanism	7
Dopamine and the phosphorylated dopamine transporter are increased in the diacylglycerol kinase η‐knockout mouse brain	7
Identification of the fatty acid coenzyme‐A ligase FadD1 as an interacting partner of FptX in the Pseudomonas aeruginosa pyochelin pathway	7
Negative feedback and modern anti‐cancer strategies targeting the ER stress response	7
Disulfide bond formation and redox regulation in the Golgi apparatus	7
Does Lactobacillus reuteri influence ergothioneine levels in the human body?	7
Strain‐level immunomodulatory variation of gut bacteria	7
The deubiquitinating enzyme USP17 regulates c‐Myc levels and controls cell proliferation and glycolysis	7
The emerging landscape of eukaryotic polyphosphatases	7
Enzymatic activity of the blue light‐regulated phosphodiesterase BlrP1 from Klebsiella pneumoniae shows a nonlinear dependence on light intensity	7
The role of brain innate immune response in lysosomal storage disorders: fundamental process or evolutionary side effect?	7
Cytochrome c oxidase biogenesis – from translation to early assembly of the core subunit COX1	7
Unique structural features of the adenylate kinase hCINAP/AK6 and its multifaceted functions in carcinogenesis and tumor progression	7
The archaeal division protein CdvB1 assembles into polymers that are depolymerized by CdvC	7
K+ regulates relocation of Pellino‐2 to the site of NLRP3 inflammasome activation in macrophages	7
Overactivation of the androgen receptor exacerbates gravid uterine ferroptosis via interaction with and suppression of the NRF2 defense signaling pathway	7
CIDE proteins and their regulatory mechanisms in lipid droplet fusion and growth	7
Copper binding and reactivity at the histidine brace motif: insights from mutational analysis of the Pseudomonas fluorescens copper chaperone CopC	7
Targeting the non‐ATP‐binding pocket of the MAP kinase p38γ mediates a novel mechanism of cytotoxicity in cutaneous T‐cell lymphoma (CTCL)	7
The cyclin‐dependent kinase inhibitor p27Kip1 interacts with the aryl hydrocarbon receptor and negatively regulates its transcriptional activity	7
Combinatorial pathway disruption is a powerful approach to delineate metabolic impacts of endocrine disruptors	7
Azurocidin is loaded into small extracellular vesicles via its N‐linked glycosylation and promotes intravasation of renal cell carcinoma cells	6
Structural characterization of the porcine adeno‐associated virus Po1 capsid protein binding to the nuclear trafficking protein importin alpha	6
hnRNPA1 enhances FOXP3 stability to promote the differentiation and functions of regulatory T cells	6
Sphingomyelinases in a journey to combat arthropod‐borne pathogen transmission	6
Promiscuous activity of β‐carotene hydroxylase CrtZ on epoxycarotenoids leads to the formation of rare carotenoids with 6‐hydroxy‐3‐keto‐ε‐ends	6
Dynamical activation of function in metalloenzymes	6
Basic fibroblast growth factor uniquely stimulates quiescent vascular smooth muscle cells and induces proliferation and dedifferentiation	6
Shedding Light on the Role of Phosphorylation in Plant Autophagy	6
Chances and challenges of long‐distance electron transfer for cellular redox reactions	6
Docking and molecular simulations reveal a quinone‐binding site on the surface of respiratory complex I	6
Crystal structure of the stalk region of axonemal inner‐arm dynein‐d reveals unique features in the coiled‐coil and microtubule‐binding domain	6