FEBS Letters

Article	Citations
The prefoldin‐like protein AtURI exhibits characteristics of intrinsically disordered proteins	166
Art and Science break boundaries in The Garden of Earthly Delights	155
Front Cover	85
Time‐resolved transcriptomics of mouse gastric pit cells during postnatal development reveals features distinct from whole stomach development	64
Probing the legitimate initiation of RNA synthesis by Qβ replicase with oligonucleotide primers	60
Front Cover	58
Thermodynamic versus kinetic basis for the high conformational stability of nanobodies for therapeutic applications	50
	44
Transcription as a double‐edged sword in genome maintenance	39
Sharing biological data: why, when, and how	38
Front Cover	37
Front Cover	37
Front Cover	34
Are casein micelles extracellular condensates formed by liquid‐liquid phase separation?	34
Front Cover	32
	32
Mutational analysis of the functional motifs of the DEAD‐box RNA helicase Me31B/DDX6 in Drosophila germline development	31
Divergent effects of cholesterol on the structure and fluidity of liposome and catanionic vesicle membranes	31
NADPH‐to‐NADH conversion by mitochondrial transhydrogenase is indispensable for sustaining anaerobic metabolism in Euglena gracilis	31
Artificial miRNAs derived from miR‐181 family members have potential in cancer therapy due to an altered spectrum of target mRNAs	30
Front Cover	30
Front Cover	30
The fatty acid synthase inhibitor C75 differentially affects the adipogenic differentiation of multipotent cells and preadipocytes	28
Mycobacterium tuberculosis low molecular weight T‐cell antigen Mtb8.4 has heme‐binding and fiber‐forming properties	28
Overexpression of polyphosphate polymerases and deletion of polyphosphate phosphatases shorten the replicative lifespan in yeast	27

Front Cover	27
Expression of Concern	26
Retraction statement: MicroRNA‐575 targets BLID to promote growth and invasion of non‐small cell lung cancer cells	25
Retraction Statement: The circadian rhythm regulator RpaA modulates photosynthetic electron transport and alters the preferable temperature range for growth in a cyanobacterium	24
RETRACTION: Theaflavins Retard Human Breast Cancer Cell Migration by Inhibiting NF‐κB via p53‐ROS Cross‐talk	24
Insight into the function of the Golgi membrane protein GOLM1 in cholangiocytes through interactomic analysis	23
IL‐6 mediated CD206+ARG‐1+ tumor associated macrophage polarization induces Treg infiltration in non‐responder luminal A breast cancer	22
Characteristics of the Kelch domain containing (KLHDC) subfamily and relationships with diseases	22
Phenylalanine stacking enhances the red fluorescence of biliverdin IXα on UV excitation in sandercyanin fluorescent protein	21
Front Cover	21
	21
Inclusion, belonging, and institutional climate – overlooked factors driving diverse STEM faculty turnover?	21
Front Cover	21
CRK and NCK adaptors may functionally overlap in zebrafish neurodevelopment, as indicated by common binding partners and overlapping expression patterns	20
Reprogramming nucleolar size by genetic perturbation of the extranuclear Rab GTPases Ypt6 and Ypt32	20
Secreted acid phosphatases maintain replicative lifespan via inositol polyphosphate metabolism in budding yeast	19
iChIP‐SILAC analysis identifies epigenetic regulators of CpG methylation of the p16INK4A gene	19
Interdomain electron transfer in flavohaemoglobin from Candida norvegensis with antibiotic azole compounds	18
A quest to unravel the role of the stalk and microtubule‐binding domain of axonemal dyneins	18
	18
Peroxisomes undergo morphological changes in a light‐dependent manner with proximity to the nucleus	18
Arabidopsis mutants lacking DLDG1 and non‐photochemical quenching‐related proteins reveal the regulatory role of DLDG1 in chloroplast pH homeostasis	18
Novel insights into autophagosome biogenesis revealed by cryo‐electron tomography	18
Front Cover	17
PARP1–RNA interaction analysis: PARP1 regulates the expression of extracellular matrix‐related genes in HK‐2 renal proximal tubular epithelial cells	17
Dietary (poly)phenols as modulators of the biophysical properties in endothelial cell membranes: its impact on nitric oxide bioavailability in hypertension	17
The structure of a Lactobacillus helveticus chlorogenic acid esterase and the dynamics of its insertion domain provide insights into substrate binding	17
dAsap regulates cellular protrusions via an Arf6‐dependent actin regulatory pathway in S2R+ cells	17
Comparative structural and functional analysis of the glycine‐rich regions of Class A and B J‐domain protein cochaperones of Hsp70	17
BRET analysis reveals interaction between the lysophosphatidic acid receptor LPA2 and the lysophosphatidylinositol receptor GPR55 in live cells	17
Distinct classes of misfolded proteins differentially affect the growth of yeast compromised for proteasome function	17
The incredible diversity of structures and functions of ABC transporters	17
When faculty are bullied: the unacceptable costs of doing our job and what universities can and should do	16
Heparin promotes rapid fibrillation of the basic parathyroid hormone at physiological pH	16
Loss of tRNA methyltransferase 9 and DNA damage response genes in yeast confers sensitivity to aminoglycosides	16
Comparative characterization of nine novel GH51, GH54 and GH62 α‐l‐arabinofuranosidases from Penicillium subrubescens	16
	16
The Ca2+‐binding protein sorcin stimulates transcriptional activity of the unfolded protein response mediator ATF6	16
Longin domain GAP complexes in nutrient signalling, membrane traffic and neurodegeneration	16
Front Cover	16
The dopamine receptor agonist apomorphine stabilizes neurotoxic α‐synuclein oligomers	15
	15
Front Cover	15
	15
Molecular handcraft of a well‐folded protein chimera	15
	15
Strigolactone biosynthesis in rice can occur via a 9‐cis‐3‐OH‐10′‐apo‐β‐carotenal intermediate	15
	15
Plant autophagy and intracellular trafficking	15
Microscopic modulation and analysis of islets of Langerhans in living zebrafish larvae	14

Crystal structure and enzyme engineering of the broad substrate spectrum l‐amino acid oxidase 4 from the fungus Hebeloma cylindrosporum	14
Cytochrome bd‐I from Escherichia coli is catalytically active in the absence of the CydH subunit	14
Hidden biochemical fossils reveal an evolutionary trajectory for glycolysis in the prebiotic era	14
Urinary microRNA profiling in pregnant women identifies placental microRNAs that are candidate biomarkers for monitoring placental health	14
Does Lactobacillus reuteri influence ergothioneine levels in the human body?	14
Cryo‐electron microscopy of Na+,K+‐ATPase reveals how the extracellular gate locks in the E2·2K+ state	14
A cell surface‐reducing microenvironment induces early osteogenic commitment	14
Integration of DNA–RNA‐triplex‐based regulation of transcription into molecular logic gates	14
HNF4α overexpression enhances the therapeutic potential of umbilical cord mesenchymal stem/stromal cells in mice with acute liver failure	14
Front Cover	14
Skraban‐Deardorff intellectual disability syndrome‐associated mutations in WDR26 impair CTLH E3 complex assembly	13
A simplified and easy‐to‐use HIP HOP assay provides insights into chalcone antifungal mechanisms of action	13
Apolipoprotein E isoforms and their Cys‐thiol modifications impact LRP1‐mediated metabolism of triglyceride‐rich lipoproteins	13
N‐acetyloxfenicine strongly induces mitohormesis in mice as well as in insects	13
HIV‐1 replication requires optimal activation of the unfolded protein response	12
LIM protein Ajuba promotes liver cell proliferation through its involvement in DNA replication and DNA damage control	12
Asp56 in actin is critical for the full activity of the amino acid starvation‐responsive kinase Gcn2	12
The Beautiful Brain: communicating fundamental neuroscience through masterpieces of art	12
Shedding Light on the Role of Phosphorylation in Plant Autophagy	12
CCDC115 inhibits autophagy‐mediated degradation of YAP to promote cell proliferation	12
Location of the photosynthetic carbon metabolism in microcompartments and separated phases in microalgal cells	12
Interleukin‐6–interleukin‐11 receptor chimeras reveal ionomycin‐induced proteolysis beyond ADAM10	12
Fragment‐based discovery of small molecule inhibitors of the HDGFRP2 PWWP domain	11
Valosin‐containing protein regulates the stability of fused in sarcoma granules in cells by changing ATP concentrations	11
Localization of the ubiquitin ligase Dma1 to the fission yeast contractile ring is modulated by phosphorylation	11
The chromatin repressors EZH2 and Suv4‐20h coregulate cell fate specification during hippocampal development	11
Decline of ergothioneine in frailty and cognition impairment	11
miR‐4734 conditionally suppresses ER stress‐associated proinflammatory responses	11
Discovery of a novel siphonaxanthin biosynthetic precursor in Codium fragile that accumulates only by exposure to blue‐green light	11
	11
T‐cell immunosuppression in sepsis is augmented by sciatic denervation‐induced skeletal muscle atrophy	11
Diacylglycerol kinase alleviates autophagic degradation of the endoplasmic reticulum in SPT10‐deficient yeast to enhance triterpene biosynthesis	11
Single protonation of the reduced quinone in respiratory complex I drives four‐proton pumping	11
The cell division protein ZapE is targeted by the antibiotic aztreonam to induce cell filamentation in Escherichia coli	11
Puzzling out nuclear pore complex assembly	10
The autophagy of stress granules	10
ArabidopsisRAN GTPases are critical for mitosis during male and female gametogenesis	10
Transforming properties of MET receptor exon 14 skipping can be recapitulated by loss of the CBL ubiquitin ligase binding site	10
Transcriptomic insights into the virulence of Acinetobacter baumannii during infection—role of iron uptake and siderophore production genes	10
Dynamical activation of function in metalloenzymes	10
Mapping secondary substrate‐binding sites on the GH11 xylanase from Bacillus subtilis	10
You are who your friends are—nuclear pore proteins as components of chromatin‐binding complexes	10
Structural characterization of the porcine adeno‐associated virus Po1 capsid protein binding to the nuclear trafficking protein importin alpha	10
Protein translocation in mitochondria: Sorting out the Toms, Tims, Pams, Sams and Mia	10
	10
Front Cover	10
PACS‐1 contains distinct motifs for nuclear‐cytoplasmic transport and interacts with the RNA‐binding protein PTBP1 in the nucleus and cytosol	10
Sphingomyelinases in a journey to combat arthropod‐borne pathogen transmission	10
Multiorgan microphysiological systems as tools to interrogate interorgan crosstalk and complex diseases	10
Crossing paths: recent insights in the interplay between autophagy and intracellular trafficking in plants	10
Activity of the pleiotropic drug resistance transcription factors Pdr1p and Pdr3p is modulated by binding site flanking sequences	10
Identification of novel anti‐leishmanials targeting glutathione synthetase of the parasite: a drug repurposing approach	10
The APC10 subunit of the anaphase‐promoting complex/cyclosome orchestrates NLRP3 inflammasome activation during the cell cycle	10
Cordycepin generally inhibits growth factor signal transduction in a systems pharmacology study	9
Gene editing in liver diseases	9
Micromanaging the neuroendocrine system – A review on miR‐7 and the other physiologically relevant miRNAs in the hypothalamic–pituitary axis	9
Promiscuous activity of β‐carotene hydroxylase CrtZ on epoxycarotenoids leads to the formation of rare carotenoids with 6‐hydroxy‐3‐keto‐ε‐ends	9
Activation of the purinergic receptor P2X7 improves hepatosteatosis by promoting lipophagy	9
Binding and/or hydrolysis of purine‐based nucleotides is not required for IM30 ring formation	9
Brain lipidomic profiles of sleep enhancement through co‐administration of alprazolam and CGS21680	9
Nrf2 as a regulator of energy metabolism and mitochondrial function	9
Molecular principles of bidirectional signalling between membranes and small GTPases	9
Mitochondrial [2Fe‐2S] ferredoxins: new functions for old dogs	9
α‐Helices propagating from stable nucleators exhibit unconventional thermal folding	9
Molecular and mechanical mechanisms of animal cell abscission	9
Epitope analysis of human monoclonal antibodies from a patient with autoimmune factor XIII deficiency reveals their inhibitory mechanisms	9
Dissecting the Ca2+ dependence of DesA1 function in Mycobacterium tuberculosis	9
Increased ROS levels in mitochondrial outer membrane protein Mul1‐deficient oocytes result in abnormal preimplantation embryogenesis	9
Remodelling of mitochondrial function by import of specific lipids at multiple membrane‐contact sites	9
Clinical and mechanistic insights into the roles of DDX41 in haematological malignancies	8
Mice deficient in the phosphatase activity of sEH show decreased levels of the endocannabinoid 2‐AG in the olfactory bulb and depressive‐like behavior	8
The Cys‐Pro motifs in the intrinsically disordered regions of the transcription factor BACH1 mediate distinct and overlapping functions upon heme binding	8
Heme‐dependent recognition of 5‐aminolevulinate synthase by the human mitochondrial molecular chaperone ClpX	8
EGR1 plays an important role in BMP9‐mediated osteoblast differentiation by promoting SMAD1/5 phosphorylation	8
The proximity interactome of PML isoforms I and II under fatty acid stress	8
SARS‐CoV‐2 spike protein aggregation is triggered by bacterial lipopolysaccharide	8
	8
Suppression of amber stop codons impairs pathogenicity in Salmonella	8
(Poly)phenols and brain health – beyond their antioxidant capacity	8
A γ‐glutamyl hydrolase lacking the signal peptide confers susceptibility to folates/antifolates in acute lymphoblastic leukemia cells	8

The FEBS 60th anniversary writing contest—blueprints for the scientific society of tomorrow	8
Front Cover	8
Docking and molecular simulations reveal a quinone‐binding site on the surface of respiratory complex I	8
Basic fibroblast growth factor uniquely stimulates quiescent vascular smooth muscle cells and induces proliferation and dedifferentiation	8
Blueprints for the scientific society of the future: how FEBS and other scientific societies will have changed 60 years from now	8
Structural basis for the recognition of the S2, S5‐phosphorylated RNA polymerase II CTD by the mRNA anti‐terminator protein hSCAF4	8
Breaking the silence around academic harassment	8
Front Cover	8
Single‐dose immunisation with a multimerised SARS‐CoV‐2 receptor binding domain (RBD) induces an enhanced and protective response in mice	8
The scorpion toxin BeKm‐1 blocks hERG cardiac potassium channels using an indispensable arginine residue	8
Mitochondrial respiratory complex I can be inhibited via bypassing the ubiquinone‐accessing tunnel	8
Structural modeling and characterization of the Mycobacterium tuberculosisMmpL3 C‐terminal domain	7
Azurocidin is loaded into small extracellular vesicles via its N‐linked glycosylation and promotes intravasation of renal cell carcinoma cells	7
The radical impact of oxygen on prokaryotic evolution—enzyme inhibition first, uninhibited essential biosyntheses second, aerobic respiration third	7
Knockout of the BRAP homolog in mice leads to abnormal tracheal cilia	7
EU‐LIFE charter of independent life science research institutes	7
Cell–cell adhesions in embryonic stem cells regulate the stability and transcriptional activity of β‐catenin	7
An update on post‐transcriptional regulation of retrotransposons	7
Chances and challenges of long‐distance electron transfer for cellular redox reactions	7
Genome‐wide analysis of the mouse LIM gene family reveals its roles in regulating pathological cardiac hypertrophy	7
Glu592 of the axon guidance receptor ROBO3 mediates a pH‐dependent interaction with NELL2 ligand	7
Inflammasomes in epithelial innate immunity: front line warriors	7
	7
Interorgan crosstalk in pancreatic islet function and pathology	7
Non‐negative blind deconvolution for signal processing in a CRISPR‐edited iPSC‐cardiomyocyte model of dilated cardiomyopathy	7
Interlinked bi‐stable switches govern the cell fate commitment of embryonic stem cells	7
Cell competition: emerging signaling and unsolved questions	7
Two phosphoenolpyruvate carboxykinases with differing biochemical properties in Chlamydomonas reinhardtii	7
The sphingolipid anteome: implications for evolution of the sphingolipid metabolic pathway	7
Front Cover	7
Cryo‐EM structure of the full‐length Lon protease from Thermus thermophilus	7
Conjugative transfer of the IncN plasmid pKM101 is mediated by dynamic interactions between the TraK accessory factor and TraI	7
Liver gene transfer for metabolite detoxification in inherited metabolic diseases	7
EZH2 modulates retinoic acid signaling to ensure myotube formation during development	7
Structure‐based design of peptidomimetic inhibitors of PSD‐95 with improved affinity for the PDZ3 domain	7
A single evolutionarily divergent mutation determines the different FAD‐binding affinities of human and rat NQO1 due to site‐specific phosphorylation	7
Uncovering domain motif interactions using high‐throughput protein–protein interaction detection methods	7
A gold revision of the Golgi Dynamics (GOLD) domain structure and associated cell functionalities	7
Front Cover	6
Protein engineering of antifreeze proteins reveals that their activity scales with the area of the ice‐binding site	6
SIRT5 mutants reveal the role of conserved asparagine and glutamine residues in the NAD+‐binding pocket	6
Front Cover	6
Structural insights into rapamycin‐induced oligomerization of a FRB–FKBP fusion protein	6
Quinone chemistry in respiratory complex I involves protonation of a conserved aspartic acid residue	6
In situ glucosylceramide synthesis and its pharmacological inhibition analysed in cells by 13C5‐sphingosine precursor feeding and mass spectrometry	6
Interface‐based design of the favipiravir‐binding site in SARS‐CoV‐2 RNA‐dependent RNA polymerase reveals mutations conferring resistance to chain termination	6
Genetic, metabolic and immunological features of cancers with NRF2 addiction	6
Structural insights into the inhibitory mechanism of angiotensin‐I‐converting enzyme by the lactotripeptides IPP and VPP	6
Nuclear envelope‐remodeling events as models to assess the potential role of membranes on genome stability	6
Corrigendum	6
Front Cover	6
The anti‐TLR4 monoclonal antibody Sa15‐21 enhances inflammatory cytokine production in LPS‐stimulated macrophages	6
‘GutFeel’: an in silico method for predicting gut health status based on the metabolic functional capabilities of the resident microbiome	6
The fusion of quantitative molecular proteomics and immune‐oncology: a step towards precision medicine in cancer therapeutics	6
Crystal structure of the stalk region of axonemal inner‐arm dynein‐d reveals unique features in the coiled‐coil and microtubule‐binding domain	6
Loss of the adaptor protein Sh3bgrl initiates ovarian fibrosis in zebrafish	6
Multiplexed imaging to reveal tissue dendritic cell spatial localisation and function	6
The mitotic checkpoint kinase BUB1 is a direct and actionable target of MYB in adenoid cystic carcinoma	6
hnRNPA1 enhances FOXP3 stability to promote the differentiation and functions of regulatory T cells	6
The therapeutic capacity of bone marrow MSC‐derived extracellular vesicles in Achilles tendon healing is passage‐dependent and indicated by specific glycans	6
A two‐step mechanism for the binding of the HIV‐1 MPER epitope by the 10E8 antibody onto biosensor‐supported lipid bilayers	6
Front Cover	6
ABC transporter activity is affected by the size of lipid nanodiscs	6
Lipid droplets provide metabolic flexibility for cancer progression	6
Hepatocyte nuclear factor HNF1A is a potential regulator in shaping the super‐enhancer landscape in colorectal cancer liver metastasis	6
Reducing plastic waste in scientific protocols by 65% — practical steps for sustainable research	6
	6
	6
Regulation of epithelial‐to‐mesenchymal transition in hypoxia by the HIF‐1α network	6
ICLAMP: a novel technique to explore adenosine deamination via inosine chemical labeling and affinity molecular purification	6
The ubiquitin–proteasome system and autophagy mutually interact in neurotoxin‐induced dopaminergic cell death models of Parkinson's disease	6
The structure of a haemoglobin–nanobody complex reveals human β‐subunit‐specific interactions	6
Pseudouridines in RNAs: switching atoms means shifting paradigms	6
Siderophore specificities of the Pseudomonas aeruginosa TonB‐dependent transporters ChtA and ActA	6
Five problems plaguing publishing in the life sciences—and one common cause	6
Bacterial Growth Inhibition Screen (BGIS): harnessing recombinant protein toxicity for rapid and unbiased interrogation of protein function	6
The structure of COPI vesicles and regulation of vesicle turnover	6
Silica‐coated magnetic nanobeads in a flow enrichment target capture Halbach (FETCH) magnetic separation system for circulating tumor cell enrichment	6
A weak COPI binding motif in the cytoplasmic tail of SARS‐CoV‐2 spike glycoprotein is necessary for its cleavage, glycosylation, and localization	6
Corrigendum	6
Transcriptional regulation of basophil‐specific protease genes by C/EBPα, GATA2, TGF‐β signaling, and epigenetic mechanisms	6
A historical perspective of macroautophagy regulation by biochemical and biomechanical stimuli	6
Unlocking the biochemical secrets of longevity: balancing healthspan and lifespan	5
A factory within a yeast cell: innovative approaches for a sustainable future – an interview with Irina Borodina	5
Age‐associated myeloid malignancies – the role of STAT3 and STAT5 in myelodysplastic syndrome and acute myeloid leukemia	5
Structural and functional insights of itaconyl‐CoA hydratase from Pseudomonas aeruginosa highlight a novel N‐terminal hotdog fold	5
Generation and characterization of a high‐affinity chimeric anti‐OX40 antibody with potent antitumor activity	5
A Pellino‐2 variant is associated with constitutive NLRP3 inflammasome activation in a family with ocular pterygium–digital keloid dysplasia	5
The 19S proteasome subunit Rpt5 reversibly associates with cold‐stable microtubules in glial cells at low temperatures	5
Insights into conformational changes in cytochrome b during the early steps of its maturation	5
Front Cover	5
Mitochondrial ferritin expression in human macrophages is facilitated by thrombin‐mediated cleavage under hypoxia	5
Two years into COVID‐19 – Lessons in SARS‐CoV‐2 and a perspective from papers in FEBS Letters	5
Structural basis for the minimal bifunctional alginate epimerase AlgE3 from Azotobacter chroococcum	5
Homocysteine thiolactone and H2O2 induce amino acid modifications and alter the fibrillation propensity of the Aβ25–35 peptide	5