Experimental Eye Research

Article	Citations
Corneal neovascularization	111
Inflammatory basis for dry eye disease flares	83
Corneal myofibroblasts and fibrosis	75
Spectacle: An interactive resource for ocular single-cell RNA sequencing data analysis	63
USH2A-retinopathy: From genetics to therapeutics	61
TGF beta −1, −2 and −3 in the modulation of fibrosis in the cornea and other organs	61
The role of fungi in fungal keratitis	55
Systemic diseases and the cornea	51
Genetics vs chronic corneal mechanical trauma in the etiology of keratoconus	50
Long noncoding RNA MIAT regulates primary human retinal pericyte pyroptosis by modulating miR-342–3p targeting of CASP1 in diabetic retinopathy	49
Candidate pathways for retina to scleral signaling in refractive eye growth	45
Update on the genetics of keratoconus	44
TGFβ1 and TGFβ2 proteins in corneas with and without stromal fibrosis: Delayed regeneration of apical epithelial growth factor barrier and the epithelial basement membrane in corneas with stromal fibr	42
Inherited cataracts: Genetic mechanisms and pathways new and old	41
The role of reactive oxygen species in the pathogenesis and treatment of retinal diseases	41
Hypercytokinemia in COVID-19: Tear cytokine profile in hospitalized COVID-19 patients	39
Foundational concepts in the biology of bacterial keratitis	39
N-retinylidene-N-retinylethanolamine adduct induces expression of chronic inflammation cytokines in retinal pigment epithelium cells	38
Evolution of oxidative stress, inflammation and neovascularization in the choroid and retina in a subretinal lipid induced age-related macular degeneration model	38
A tissue-engineered human trabecular meshwork hydrogel for advanced glaucoma disease modeling	38
Melanopsin modulates refractive development and myopia	37
Corneal fibroblasts: Function and markers	37
The biology of Acanthamoeba keratitis	37
Biochemistry of human tear film: A review	37
Cell culture models to study retinal pigment epithelium-related pathogenesis in age-related macular degeneration	37

Melatonin ameliorates oxidative stress-mediated injuries through induction of HO-1 and restores autophagic flux in dry eye	36
Protection of retinal ganglion cells in glaucoma: Current status and future	36
Corneal biomechanics: Measurement and structural correlations	35
GSDMD, an executor of pyroptosis, is involved in IL-1β secretion in Aspergillus fumigatus keratitis	35
Limbal stem cell diseases	34
Retinal pigment epithelial cells secrete miR-202-5p-containing exosomes to protect against proliferative diabetic retinopathy	34
The biology of corneal cross-linking derived from ultraviolet light and riboflavin	33
Corneal angiogenic privilege and its failure	32
Increased ratios of complement factors C3a to C3 in aqueous humor and serum mark glaucoma progression	31
Topical losartan inhibits corneal scarring fibrosis and collagen type IV deposition after Descemet's membrane-endothelial excision in rabbits	31
Topical ocular drug delivery systems: Innovations for an unmet need	30
Progress in developing rodent models of age-related macular degeneration (AMD)	30
Novel insights into gene therapy in the cornea	30
The potential role of m6A RNA methylation in diabetic retinopathy	30
Neuroprotective effect of melatonin loaded in ethylcellulose nanoparticles applied topically in a retinal degeneration model in rabbits	29
Tumor necrosis factor-alpha and interferon-gamma induce inflammasome-mediated corneal endothelial cell death	29
Single cell transcriptomics of the developing zebrafish lens and identification of putative controllers of lens development	29
Resveratrol protects retinal ganglion cell axons through regulation of the SIRT1-JNK pathway	29
Ectatic diseases	29
Mechanisms of organelle elimination for lens development and differentiation	29
Wedelolactone ameliorates Pseudomonas aeruginosa-induced inflammation and corneal injury by suppressing caspase-4/5/11/GSDMD-mediated non-canonical pyroptosis	28
Single cell RNA sequencing (scRNA-Seq) deciphering pathological alterations in streptozotocin-induced diabetic retinas	28
Pathobiology and treatment of viral keratitis	28
Connexin43 hemichannel block inhibits NLRP3 inflammasome activation in a human retinal explant model of diabetic retinopathy	28
Hallmarks of lens aging and cataractogenesis	28
3D in vitro corneal models: A review of current technologies	27
Corneal Nerve Abnormalities in Ocular and Systemic Diseases	26
Metabolomic profiling of aqueous humor from glaucoma patients - The metabolomics in surgical ophthalmological patients (MISO) study	26
Lutein and zeaxanthin reduce A2E and iso-A2E levels and improve visual performance in Abca4/Bco2 double knockout mice	26
Proteoglycan 4 (PRG4) expression and function in dry eye associated inflammation	26
Status of oxidative stress markers, advanced glycation index, and polyol pathway in age-related cataract subjects with and without diabetes	26
Alterations in the conjunctival surface bacterial microbiome in bacterial keratitis patients	26
Efficacy of topotecan nanoparticles for intravitreal chemotherapy of retinoblastoma	25
Inhibition of matrix metalloproteinase-9 for the treatment of dry eye syndrome; a review study	25
CircFAT1 regulates retinal pigment epithelial cell pyroptosis and autophagy via mediating m6A reader protein YTHDF2 expression in diabetic retinopathy	25
Functional integration of eye tissues and refractive eye development: Mechanisms and pathways	25
Knockdown of Malat1 alleviates high-glucose-induced angiogenesis through regulating miR-205-5p/VEGF-A axis	25
Immune regulation of the ocular surface	25
Glycyrrhizin micelle as a genistein nanocarrier: Synergistically promoting corneal epithelial wound healing through blockage of the HMGB1 signaling pathway in diabetic mice	25
Different modes of full-thickness macular hole formation	25
Mechanisms of RPE senescence and potential role of αB crystallin peptide as a senolytic agent in experimental AMD	25
Overexpression of S100A4 protects retinal ganglion cells against retinal ischemia-reperfusion injury in mice	25
Corneal nerves and their role in dry eye pathophysiology	24
Tear and ocular surface disease biomarkers: A diagnostic and clinical perspective for ocular allergies and dry eye disease	24
Protein posttranslational modification (PTM) by glycation: Role in lens aging and age-related cataractogenesis	24
Keratin expression by corneal and limbal stem cells during development	24
CHOP deletion and anti-neuroinflammation treatment with hesperidin synergistically attenuate NMDA retinal injury in mice	24
Corneal stroma regeneration: Preclinical studies	24
Diseases of the corneal endothelium	23
The role of TRPV4 channels in ocular function and pathologies	23

Corneal nerves anatomy, function, injury and regeneration	23
The cornea in keratoconjunctivitis sicca	23
RNA therapeutics in ophthalmology - translation to clinical trials	23
Procyanidin B2 and rutin in Ginkgo biloba extracts protect human retinal pigment epithelial (RPE) cells from oxidative stress by modulating Nrf2 and Erk1/2 signalling	23
Descemet's membrane injury and regeneration, and posterior corneal fibrosis, in rabbits	22
Exosomes, extracellular vesicles and the eye	22
The road to restore vision with photoreceptor regeneration	22
Resveratrol attenuates retinal ganglion cell loss in a mouse model of retinal ischemia reperfusion injury via multiple pathways	22
Commonalities of optic nerve injury and glaucoma-induced neurodegeneration: Insights from transcriptome-wide studies	22
Focus on cell therapy to treat corneal endothelial diseases	22
A mouse model of retinal hypoperfusion injury induced by unilateral common carotid artery occlusion	22
Effect of long-term inflammation on viability and function of RPE cells	21
Short chain fatty acids inhibit endotoxin-induced uveitis and inflammatory responses of retinal astrocytes	21
Biological effects of mitomycin C on late corneal haze stromal fibrosis following PRK	21
The cGAS-STING signaling pathway contributes to the inflammatory response and autophagy in Aspergillus fumigatus keratitis	21
AQP5 regulates vimentin expression via miR-124–3p.1 to protect lens transparency	21
The internal limiting membrane: Roles in retinal development and implications for emerging ocular therapies	21
Neuroprotective role of sphingolipid rheostat in excitotoxic retinal ganglion cell death	20
Development, structure, and bioengineering of the human corneal stroma: A review of collagen-based implants	20
The microRNAs miR-302d and miR-93 inhibit TGFB-mediated EMT and VEGFA secretion from ARPE-19 cells	20
The effect of nerve growth factor on corneal nerve regeneration and dry eye after LASIK	20
N-acetylcysteine alleviates ocular surface damage in STZ-induced diabetic mice by inhibiting the ROS/NLRP3/Caspase-1/IL-1β signaling pathway	20
Reassessing the suitability of ARPE-19 cells as a valid model of native RPE biology	19
Microglia depletion exacerbates retinal ganglion cell loss in a mouse model of glaucoma	19
PEDF is an endogenous inhibitor of VEGF-R2 angiogenesis signaling in endothelial cells	19
The human Descemet's membrane and lens capsule: Protein composition and biomechanical properties	19
Tree shrews do not maintain emmetropia in initially-focused narrow-band cyan light	19
Impacts of high fat diet on ocular outcomes in rodent models of visual disease	19
LncRNA KCNQ1OT1 knockdown inhibits viability, migration and epithelial-mesenchymal transition in human lens epithelial cells via miR-26a-5p/ITGAV/TGF-beta/Smad3 axis	19
Preparation and in vitro/in vivo evaluations of novel ocular micelle formulations of hesperetin with glycyrrhizin as a nanocarrier	19
Piezo1 plays a role in optic nerve head astrocyte reactivity	19
ON-bipolar cell gene expression during retinal degeneration: Implications for optogenetic visual restoration	18
The gut microbiota in retinal diseases	18
Intravitreal gene therapy protects against retinal dysfunction and degeneration in sheep with CLN5 Batten disease	18
Spectrum-frequency and genotype–phenotype analysis of rhodopsin variants	18
Role of small interfering RNA (siRNA) in targeting ocular neovascularization: A review	18
A new ophthalmic formulation containing antiseptics and dexpanthenol: In vitro antimicrobial activity and effects on corneal and conjunctival epithelial cells	18
Melatonin exerts protective effects on diabetic retinopathy via inhibition of Wnt/β-catenin pathway as revealed by quantitative proteomics	18
TNFα activates MAPK and Jak-Stat pathways to promote mouse Müller cell proliferation	18
Astaxanthin mediated regulation of VEGF through HIF1α and XBP1 signaling pathway: An insight from ARPE-19 cell and streptozotocin mediated diabetic rat model	18
Topical calcitriol application promotes diabetic corneal wound healing and reinnervation through inhibiting NLRP3 inflammasome activation	18
VDAC1 regulates mitophagy in NLRP3 inflammasome activation in retinal capillary endothelial cells under high-glucose conditions	18
Occurrence of SARS-CoV-2 in the intraocular milieu	17
N-acetylserotonin alleviated the expression of interleukin-1β in retinal ischemia–reperfusion rats via the TLR4/NF-κB/NLRP3 pathway	17
The ocular surface and diabetes, the other 21st Century epidemic	17
Linezolid shows high safety and efficacy in the treatment of Pythium insidiosum keratitis in a rabbit model	17
RAGE silencing deters CML-AGE induced inflammation and TLR4 expression in endothelial cells	17
Filtering blue light mitigates the deleterious effects induced by the oxidative stress in human retinal pigment epithelial cells	17
Rapamycin ameliorates corneal injury after alkali burn through methylation modification in mouse TSC1 and mTOR genes	17
Kaempferol alleviates corneal transplantation rejection by inhibiting NLRP3 inflammasome activation and macrophage M1 polarization via promoting autophagy	17
H2O2-induced cataract as a model of age-related cataract: Lessons learned from overexpressing the proteasome activator PA28αβ in mouse eye lens	17
circRNA-miRNA-mRNA network in age-related macular degeneration: From construction to identification	17
Decorin regulates collagen fibrillogenesis during corneal wound healing in mouse in vivo	17
The functional role of decorin in corneal neovascularization in vivo	17
Long term observation of ocular surface alkali burn in rabbit models: Quantitative analysis of corneal haze, vascularity and self-recovery	17
Minocycline suppresses disease-associated microglia (DAM) in a model of photoreceptor cell degeneration	17
Functional assessment of cryopreserved clinical grade hESC-RPE cells as a qualified cell source for stem cell therapy of retinal degenerative diseases	16
Calcitriol inhibits apoptosis via activation of autophagy in hyperosmotic stress stimulated corneal epithelial cells in vivo and in vitro	16
Interaction of alpha-crystallin with four major phospholipids of eye lens membranes	16
Viscoelastic properties of the human tear film	16
Crystallin gene expression: Insights from studies of transcriptional bursting	16
Circular RNA circ-FAM158A promotes retinoblastoma progression by regulating miR-138–5p/SLC7A5 axis	16
Role of growth factors and internal limiting membrane constituents in müller cell migration	16
Combined hyperosmolarity and inflammatory conditions in stressed human corneal epithelial cells and macrophages to evaluate osmoprotective agents as potential DED treatments	16
Real-time imaging of optic nerve head collagen microstructure and biomechanics using instant polarized light microscopy	16
Inhibition of Drp1 ameliorates diabetic retinopathy by regulating mitochondrial homeostasis	15
Corneal development: Role of the periocular mesenchyme and bi-directional signaling	15
Prostaglandin F2α and EP2 agonists, and a ROCK inhibitor modulate the formation of 3D organoids of Grave's orbitopathy related human orbital fibroblasts	15
Keratocyte mechanobiology	15
miR-21-5p: A viable therapeutic strategy for regulating intraocular pressure	15
Integrated differential DNA methylation and gene expression of formalin-fixed paraffin-embedded uveal melanoma specimens identifies genes associated with early metastasis and poor prognosis	15
Single-cell RNA-sequencing analysis of the ciliary epithelium and contiguous tissues in the mouse eye	15
The role of the inflammasomes in the pathogenesis of uveitis	15
Assessment of intraocular lens/capsular bag biomechanical interactions following cataract surgery in a human in vitro graded culture capsular bag model	15
Immune cells in lens injury repair and fibrosis	15
The role of microRNAs in glaucoma	15
Inflammation-related molecules in tears of patients with chronic ocular pain and dry eye disease	15
Esculetin protects human corneal epithelial cells from oxidative stress through Nrf-2 signaling pathway	15
Morphological factors associated with giant vacuoles with I-pores in Schlemm's canal endothelial cells of human eyes: A serial block-face scanning electron microscopy study	15
Effect of inhalation anesthesia with isoflurane on circadian rhythm of murine intraocular pressure	14

Ocular surface temperature measurement in diabetic retinopathy	14
PPP1CA/YAP/GS/Gln/mTORC1 pathway activates retinal Müller cells during diabetic retinopathy	14
The roles of mouse double minute 2 (MDM2) oncoprotein in ocular diseases: A review	14
IL-6-induced acetylation of E2F1 aggravates oxidative damage of retinal pigment epithelial cell line	14
Meibum lipid composition in type 2 diabetics with dry eye	14
Fusarium infection alters the m6A-modified transcript landscape in the cornea	14
Co-expression of the SARS-CoV-2 entry receptors ACE2 and TMPRSS2 in healthy human conjunctiva	14
Systems genomics in age-related macular degeneration	14
Redox chemistry of lens crystallins: A system of cysteines	14
Intravitreal melphalan hydrochloride vs propylene glycol-free melphalan for retinoblastoma vitreous seeds: Efficacy, toxicity and stability in rabbits models and patients	14
Interactions of cone abundancies, opsin expression, and environmental lighting with emmetropization in chickens	14
CD63+ extracellular vesicles from retinal pigment epithelial cells participate in crosstalk with macrophages in the innate inflammatory axis	14
Pathogenesis of keratoconus: NRF2-antioxidant, extracellular matrix and cellular dysfunctions	14
Aerobic exercise delays retinal ganglion cell death after optic nerve injury	14
Inlays and the cornea	14
Pathophysiology of dry eye disease and novel therapeutic targets	14
Tear film and ocular surface neuropeptides: Characteristics, synthesis, signaling and implications for ocular surface and systemic diseases	14
PLGA nanoparticles containing Lingzhi extracts rescue corneal epithelial cells from oxidative damage	13
Alzheimer's disease amyloid-β pathology in the lens of the eye	13
Microglia increase tight-junction permeability in coordination with Müller cells under hypoxic condition in an in vitro model of inner blood-retinal barrier	13
Piezo1 activation induces fibronectin reduction and PGF2α secretion via arachidonic acid cascade	13
Macrophage polarization contributes to the efficacy of an oncolytic HSV-1 targeting human uveal melanoma in a murine xenograft model	13
Targeting HDAC3 in the DBA/2J spontaneous mouse model of glaucoma	13
Novel variants in PNPLA6 causing syndromic retinal dystrophy	13
JQ1, a selective inhibitor of BRD4, suppresses retinoblastoma cell growth by inducing cell cycle arrest and apoptosis	13
RNA-binding proteins and post-transcriptional regulation in lens biology and cataract: Mediating spatiotemporal expression of key factors that control the cell cycle, transcription, cytoskeleton and t	13
Expression profiles and potential corneal epithelial wound healing regulation targets of high-mobility group box 1 in diabetic mice	13
Melanocortin receptor agonists suppress experimental autoimmune uveitis	13
Mechanosensitive channel inhibition attenuates TGFβ2-induced actin cytoskeletal remodeling and reactivity in mouse optic nerve head astrocytes	13
Strengthened rebamipide ocular nanoformulation to effectively treat corneal alkali burns in mice through the HMGB1 signaling pathway	13
IOP-induced regional displacements in the optic nerve head and correlation with peripapillary sclera thickness	13
Rabbit models of dry eye disease: Current understanding and unmet needs for translational research	13
Carbonic anhydrase inhibition in X-linked retinoschisis: An eye on the photoreceptors	13
Foveal configurations with disappearance of the foveal pit in eyes with macular pucker: Presumed role of Müller cells in the formation of foveal herniation	13
CD38 deficiency protects the retina from ischaemia/reperfusion injury partly via suppression of TLR4/MyD88/NF-κB signalling	13
Spatiotemporal determination of metabolite activities in the corneal epithelium on a chip	13
Effect of Sirt3 on retinal pigment epithelial cells in high glucose through Foxo3a/ PINK1-Parkin pathway mediated mitophagy	13
JNK/c-Jun-driven NLRP3 inflammasome activation in microglia contributed to retinal ganglion cells degeneration induced by indirect traumatic optic neuropathy	13
The aging mouse lens transcriptome	13
Declines in PDE4B activity promote myopia progression through downregulation of scleral collagen expression	13
α-MSH ameliorates corneal surface dysfunction in scopolamine-induced dry eye rats and human corneal epithelial cells via enhancing EGFR expression	13
Matrix metalloproteinases and their inhibitors in Fuchs endothelial corneal dystrophy	12
Microglia-derived TNF-α mediates Müller cell activation by activating the TNFR1-NF-κB pathway	12
Histologic validation of optical coherence tomography-based three-dimensional morphometric measurements of the human optic nerve head: Methodology and preliminary results	12
Ongoing controversies and recent insights of the ARMS2-HTRA1 locus in age-related macular degeneration	12
Change patterns in the corneal sub-basal nerve and corneal aberrations in patients with dry eye disease: An artificial intelligence analysis	12
Mutation spectrum and genotype-phenotype correlations in Chinese congenital ectopia lentis patients	12
Krüppel-like factor 7 protects retinal ganglion cells and promotes functional preservation via activating the Akt pathway after retinal ischemia-reperfusion injury	12
Decrease in DHA and other fatty acids correlates with photoreceptor degeneration in retinitis pigmentosa	12
High expression of SARS-CoV-2 entry factors in human conjunctival goblet cells	12
FP and EP2 prostanoid receptor agonist drugs and aqueous humor outflow devices for treating ocular hypertension and glaucoma	12
Evidence for endogenous exchange of cytoplasmic material between a subset of cone and rod photoreceptors within the adult mammalian retina via direct cell-cell connections	12
Optical transmittance and ultrastructure of SMILE-derived lenticules subjected to three different preservative methods	12
Effects of amygdalin on ferroptosis and oxidative stress in diabetic retinopathy progression via the NRF2/ARE signaling pathway	12
Interplay between intraocular and intracranial pressure effects on the optic nerve head in vivo	12
EPZ015666, a selective protein arginine methyltransferase 5 (PRMT5) inhibitor with an antitumour effect in retinoblastoma	12
The role of peroxisome proliferator-activated receptors in healthy and diseased eyes	12
Exosome-transmitted circ-CARD6 facilitates posterior capsule opacification development by miR-31/FGF7 axis	12
Cathepsin S is a novel target for age-related dry eye	12
RPE65-related retinal dystrophy: Mutational and phenotypic spectrum in 45 affected patients	12
Metabolic characterization of human intraocular fluid in patients with pathological myopia	12
Prolonged use of nitric oxide donor sodium nitroprusside induces ocular hypertension in mice	12
Effect of a TSPO ligand on retinal pigment epithelial cholesterol homeostasis in high-fat fed mice, implication for age-related macular degeneration	12
Retinoic acid synthesis by a population of choroidal stromal cells	11
Effect of NADPH oxidase inhibitors in an experimental retinal model of excitotoxicity	11
E-cadherin to N-cadherin switching in the TGF-β1 mediated retinal pigment epithelial to mesenchymal transition	11
Clinical characteristics and germline mutation spectrum of RB1 in Chinese patients with retinoblastoma: A dual-center study of 145 patients	11
Sensitivity and latency of ionising radiation-induced cataract	11
MiR-223 inhibits hyperosmolarity-induced inflammation through downregulating NLRP3 activation in human corneal epithelial cells and dry eye patients	11
Antimycin A-induced mitochondrial dysfunction regulates inflammasome signaling in human retinal pigment epithelial cells	11
Diagnostic performance of multifocal photopic negative response, pattern electroretinogram and optical coherence tomography in glaucoma	11
Effect of PPARγ on oxidative stress in diabetes-related dry eye	11
Advanced glycation end products in human diabetic lens capsules	11
Early diabetes impairs ON sustained ganglion cell light responses and adaptation without cell death or dopamine insensitivity	11
A human retinal microvascular endothelial-pericyte co-culture model to study diabetic retinopathy in vitro	11
Extracellular matrix dysfunction in Sorsby patient-derived retinal pigment epithelium	11
Longitudinal and simultaneous profiling of 11 modes of cell death in mouse retina post-optic nerve injury	11
Topical application of dopaminergic compounds can inhibit deprivation myopia in chicks	11
Compritol solid lipid nanoparticle formulations enhance the protective effect of betulinic acid derivatives in human Müller cells against oxidative injury	11
Luteolin inhibits the proliferation, adhesion, migration and invasion of choroidal melanoma cells in vitro	11
Gypenosides attenuate retinal degeneration in a zebrafish retinitis pigmentosa model	11
Descriptive analysis of Fibulin-3 and the extracellular vesicle marker, Alix, in drusen from a small cohort of postmortem human eyes	11
Targeting matrix stiffness-induced activation of retinal pigment epithelial cells through the RhoA/YAP pathway ameliorates proliferative vitreoretinopathy	11
Cholesterol and cholesterol bilayer domains inhibit binding of alpha-crystallin to the membranes made of the major phospholipids of eye lens fiber cell plasma membranes	11
cGMP-PKG dependent transcriptome in normal and degenerating retinas: Novel insights into the retinitis pigmentosa pathology	11
Mitochondria dynamics in the aged mice eye and the role in the RPE phagocytosis	11
Effect of age and sex on neurodevelopment and neurodegeneration in the healthy eye: Longitudinal functional and structural study in the Long–Evans rat	11
Standardization of corneal alkali burn methodology in rabbits	11
The role of Glabridin in antifungal and anti-inflammation effects in Aspergillus fumigatus keratitis	11
Hyperglycemia-induced effects on glycocalyx components in the retina	11
Omega-3 fatty acids promote neuroprotection, decreased apoptosis and reduced glial cell activation in the retina of a mouse model of OPA1-related autosomal dominant optic atrophy	11
Transcriptomics analysis of Ccl2/Cx3cr1/Crb1rd8 deficient mice provides new insights into the pathophysiology of progressive retinal degeneration	11
Biomaterials for dry eye disease treatment: Current overview and future perspectives	11
The fibrinolytic system in the cornea: A key regulator of corneal wound healing and biological defense	11
Dark-reared rd10 mice experience rapid photoreceptor degeneration with short exposure to room-light during in vivo retinal imaging	11