European Journal of Pharmacology

Article	Citations
Alzheimer's disease: Recent treatment strategies	335
Treatment for COVID-19: An overview	227
siRNA: Mechanism of action, challenges, and therapeutic approaches	198
COVID-19 vaccine: A recent update in pipeline vaccines, their design and development strategies	190
Ferroptosis involves in renal tubular cell death in diabetic nephropathy	138
ACSL family: The regulatory mechanisms and therapeutic implications in cancer	136
Dexamethasone: Therapeutic potential, risks, and future projection during COVID-19 pandemic	126
Naringenin and naringin in cardiovascular disease prevention: A preclinical review	120
Flavonols as potential antiviral drugs targeting SARS-CoV-2 proteases (3CLpro and PLpro), spike protein, RNA-dependent RNA polymerase (RdRp) and angiotensin-converting enzyme II receptor (ACE2)	106
Geniposide alleviates diabetic nephropathy of mice through AMPK/SIRT1/NF-κB pathway	105
In silico pharmacokinetic and molecular docking studies of natural flavonoids and synthetic indole chalcones against essential proteins of SARS-CoV-2	96
Current advancements and future perspectives of immunotherapy in colorectal cancer research	94
Role of natural products for the treatment of Alzheimer's disease	89
A review of potential suggested drugs for coronavirus disease (COVID-19) treatment	89
Astragalus polysaccharide prevents ferroptosis in a murine model of experimental colitis and human Caco-2 cells via inhibiting NRF2/HO-1 pathway	88
COVID-19: A review of the proposed pharmacological treatments	86
Possibility of magnesium supplementation for supportive treatment in patients with COVID-19	85
Neuroprotective role of polyphenols against oxidative stress-mediated neurodegeneration	83
Remdesivir for treatment of COVID-19; an updated systematic review and meta-analysis	80
Curcumin, a traditional spice component, can hold the promise against COVID-19?	80
NMDA and AMPA receptors dysregulation in Alzheimer's disease	77
Angiopoietin inhibitors: A review on targeting tumor angiogenesis	75
The footprint of kynurenine pathway in every cancer: a new target for chemotherapy	75
TGF-β-induced fibrosis: A review on the underlying mechanism and potential therapeutic strategies	74
In silico molecular docking analysis for repurposing therapeutics against multiple proteins from SARS-CoV-2	73

AgRP/NPY and POMC neurons in the arcuate nucleus and their potential role in treatment of obesity	71
Dapagliflozin exerts anti-inflammatory effects via inhibition of LPS-induced TLR-4 overexpression and NF-κB activation in human endothelial cells and differentiated macrophages	70
No clinical benefit of high dose corticosteroid administration in patients with COVID-19: A preliminary report of a randomized clinical trial	68
Current herbal medicine as an alternative treatment in dentistry: In vitro, in vivo and clinical studies	67
The therapeutic efficacy of quercetin in combination with antiviral drugs in hospitalized COVID-19 patients: A randomized controlled trial	67
A review on possible mechanistic insights of Nitazoxanide for repurposing in COVID-19	65
Pharmacodynamic effects and molecular mechanisms of lignans from Schisandra chinensis Turcz. (Baill.), a current review	63
The natural (poly)phenols as modulators of microglia polarization via TLR4/NF-κB pathway exert anti-inflammatory activity in ischemic stroke	61
Fisetin, potential flavonoid with multifarious targets for treating neurological disorders: An updated review	59
The pharmacological activity of berberine, a review for liver protection	59
Vascular disrupting agents in cancer therapy	58
The Egr-1/miR-15a-5p/GPX4 axis regulates ferroptosis in acute myocardial infarction	58
Therapeutic potential of MCC950, a specific inhibitor of NLRP3 inflammasome	57
Angiogenesis as a potential treatment strategy for rheumatoid arthritis	56
The role of VEGF in cancer-induced angiogenesis and research progress of drugs targeting VEGF	56
Antiviral activity of chlorpromazine, fluphenazine, perphenazine, prochlorperazine, and thioridazine towards RNA-viruses. A review	55
MicroRNA-mediated autophagy regulation in cancer therapy: The role in chemoresistance/chemosensitivity	55
The role of CD44 in cancer chemoresistance: A concise review	55
Unraveling the mechanism of arbidol binding and inhibition of SARS-CoV-2: Insights from atomistic simulations	54
Modulation of the tumor microenvironment (TME) by melatonin	53
Integrative transcriptomics analysis of lung epithelial cells and identification of repurposable drug candidates for COVID-19	53
Capsaicin: TRPV1-independent mechanisms and novel therapeutic possibilities	52
The PI3K/Akt/mTOR signaling pathway in gastric cancer; from oncogenic variations to the possibilities for pharmacologic interventions	50
Ginsenoside Rg1 ameliorated experimental colitis by regulating the balance of M1/M2 macrophage polarization and the homeostasis of intestinal flora	50
Ameliorating and protective effects mesalazine on ethanol-induced gastric ulcers in experimental rats	49
Parkinson's disease in women: Mechanisms underlying sex differences	49
JAK/STAT pathway promotes the progression of diabetic kidney disease via autophagy in podocytes	48
Mesenchymal stem cell-based nanoparticles and scaffolds in regenerative medicine	48
Current trends and future perspectives of nanomedicine for the management of colon cancer	48
Thymosin beta 4 alleviates non-alcoholic fatty liver by inhibiting ferroptosis via up-regulation of GPX4	48
Targeting the NRF2/KEAP1 pathway in cervical and endometrial cancers	47
Pharmacological activation of Nrf2 promotes wound healing	47
Atractylenolides, essential components of Atractylodes-based traditional herbal medicines: Antioxidant, anti-inflammatory and anticancer properties	47
Crosstalk between endoplasmic reticulum stress and oxidative stress: Focus on protein disulfide isomerase and endoplasmic reticulum oxidase 1	47
Role of leukotriene pathway and montelukast in pulmonary and extrapulmonary manifestations of Covid-19: The enigmatic entity	46
Anticancer natural medicines: An overview of cell signaling and other targets of anticancer phytochemicals	45
Promising targets of chrysin and daidzein in colorectal cancer: Amphiregulin, CXCL1, and MMP-9	44
Potential pharmacologic treatments for COVID-19 smell and taste loss: A comprehensive review	43
Use of steroids in COVID-19 patients: A meta-analysis	43
TRP channels in cancer pain	42
Therapeutic applications of herbal/synthetic/bio-drug in oral cancer: An update	42
Nectin cell adhesion molecule-4 (NECTIN-4): A potential target for cancer therapy	41
Quercetin alleviates ferroptosis accompanied by reducing M1 macrophage polarization during neutrophilic airway inflammation	41
Coptisine ameliorates DSS-induced ulcerative colitis via improving intestinal barrier dysfunction and suppressing inflammatory response	41
Ferroptosis triggered by dihydroartemisinin facilitates chlorin e6 induced photodynamic therapy against lung cancer through inhibiting GPX4 and enhancing ROS	40
Syringaresinol attenuates sepsis-induced cardiac dysfunction by inhibiting inflammation and pyroptosis in mice	40
Antidepressants’ effects on testosterone and estrogens: What do we know?	40
Research progress in use of traditional Chinese medicine monomer for treatment of non-alcoholic fatty liver disease	40
The effect of oleuropein on apoptotic pathway regulators in breast cancer cells	39
A research update on the therapeutic potential of rhein and its derivatives	39

A comprehensive review on pharmacology of efflux pumps and their inhibitors in antibiotic resistance	38
Therapeutic Insights on Ferroptosis in Parkinson's disease	38
Advancement in leishmaniasis diagnosis and therapeutics: An update	38
Effects of Hsp90 inhibitor on the RIP1-RIP3-MLKL pathway during the development of heart failure in mice	37
Ferroportin-mediated ferroptosis involved in new-onset atrial fibrillation with LPS-induced endotoxemia	37
FoxO1 signaling as a therapeutic target for type 2 diabetes and obesity	37
PI3K/Akt/GSK-3β signal pathway is involved in P2X7 receptor-induced proliferation and EMT of colorectal cancer cells	37
CircRNA CDR1as promotes cardiomyocyte apoptosis through activating hippo signaling pathway in diabetic cardiomyopathy	37
Investigation of beta-lactoglobulin derived bioactive peptides against SARS-CoV-2 (COVID-19): In silico analysis	37
AMP-activated protein kinase: An attractive therapeutic target for ischemia-reperfusion injury	36
Aloe-emodin induces autophagy and apoptotic cell death in non-small cell lung cancer cells via Akt/mTOR and MAPK signaling	36
Potential repurposing of the HDAC inhibitor valproic acid for patients with COVID-19	36
Vitexin restores pancreatic β-cell function and insulin signaling through Nrf2 and NF-κB signaling pathways	36
The anti-asthmatic potential of flavonol kaempferol in an experimental model of allergic airway inflammation	36
Corticosteroid therapy is associated with the delay of SARS-CoV-2 clearance in COVID-19 patients	35
Abaloparatide: A review of preclinical and clinical studies	35
Dermatological applications of the flavonoid phloretin	35
Hypoxia-inducible factor-prolyl hydroxylase inhibitors for renal anemia in chronic kidney disease: Advantages and disadvantages	35
The prophylaxis and treatment potential of supplements for COVID-19	35
Role of RhoA-ROCK signaling in Parkinson's disease	35
Effect of chitosan oligosaccharide-conjugated selenium on improving immune function and blocking gastric cancer growth	34
Berberrubine attenuates potassium oxonate- and hypoxanthine-induced hyperuricemia by regulating urate transporters and JAK2/STAT3 signaling pathway	34
Dauricine alleviated secondary brain injury after intracerebral hemorrhage by upregulating GPX4 expression and inhibiting ferroptosis of nerve cells	34
Nanocarriers for treatment of dermatological diseases: Principle, perspective and practices	34
The cannabinoid CB2 receptor agonist LY2828360 synergizes with morphine to suppress neuropathic nociception and attenuates morphine reward and physical dependence	34
Gamma delta (γδ) T cells in cancer immunotherapy; where it comes from, where it will go?	34
Tissue distributions of antiviral drugs affect their capabilities of reducing viral loads in COVID-19 treatment	33
The emerging roles of HDACs and their therapeutic implications in cancer	33
Activation of the Nrf2/HO-1 signaling pathway by dimethyl fumarate ameliorates complete Freund's adjuvant-induced arthritis in rats	33
Functional and druggability analysis of the SARS-CoV-2 proteome	33
A ghrelin receptor antagonist reduces the ability of ghrelin, alcohol or amphetamine to induce a dopamine release in the ventral tegmental area and in nucleus accumbens shell in rats	33
Emodin prevents renal ischemia-reperfusion injury via suppression of CAMKII/DRP1-mediated mitochondrial fission	32
Ferroptosis as a new therapeutic opportunity for nonviral liver disease	32
Virtual high throughput screening: Potential inhibitors for SARS-CoV-2 PLPRO and 3CLPRO proteases	32
Fibroblast growth factor 21 inhibited inflammation and fibrosis after myocardial infarction via EGR1	32
Gambogic acid potentiates gemcitabine induced anticancer activity in non-small cell lung cancer	32
IL-6 promotes nuclear translocation of HIF-1α to aggravate chemoresistance of ovarian cancer cells	32
Role of pyroptosis in cancer and its therapeutic regulation	31
SARS-CoV-2 entry inhibitors by dual targeting TMPRSS2 and ACE2: An in silico drug repurposing study	31
Therapeutic potential of quercetin in an animal model of PCOS: Possible involvement of AMPK/SIRT-1 axis	31
Scutellarin ameliorates colitis-associated colorectal cancer by suppressing Wnt/β-catenin signaling cascade	31
Recent progress of antiviral therapy for coronavirus disease 2019	31
Should ACE2 be given a chance in COVID-19 therapeutics: A semi-systematic review of strategies enhancing ACE2	31
Repositioning of histamine H1 receptor antagonist: Doxepin inhibits viropexis of SARS-CoV-2 Spike pseudovirus by blocking ACE2	31
Preventive and therapeutic role of betaine in liver disease: A review on molecular mechanisms	30
Association of ACE inhibitors and angiotensin type II blockers with ACE2 overexpression in COVID-19 comorbidities: A pathway-based analytical study	30
Iron oxide nanoparticles loaded with paclitaxel inhibits glioblastoma by enhancing autophagy-dependent ferroptosis pathway	30
Pharmacological inhibition of fatty acid-binding protein 4 alleviated kidney inflammation and fibrosis in hyperuricemic nephropathy	30
Macrophage phenotype-switching in cancer	30
Targeting EHMT2/ G9a for cancer therapy: Progress and perspective	30
Phillygenin inhibited LPS-induced RAW 264.7 cell inflammation by NF-κB pathway	30
Dihydroartemisinin inhibits the growth of pancreatic cells by inducing ferroptosis and activating antitumor immunity	30
Coumarins derivatives and inflammation: Review of their effects on the inflammatory signaling pathways	30
Colchicine alleviates inflammation and improves diastolic dysfunction in heart failure rats with preserved ejection fraction	30
Melatonin and gastrointestinal cancers: Current evidence based on underlying signaling pathways	30
Andrographolide protects against isoproterenol-induced myocardial infarction in rats through inhibition of L-type Ca2+ and increase of cardiac transient outward K+ currents	29
Salicylic acid in ginseng root alleviates skin hyperpigmentation disorders by inhibiting melanogenesis and melanosome transport	29
Brief review on repurposed drugs and vaccines for possible treatment of COVID-19	29
Xanthohumol attenuates isoprenaline-induced cardiac hypertrophy and fibrosis through regulating PTEN/AKT/mTOR pathway	29
Efficacy and safety of dihydroorotate dehydrogenase (DHODH) inhibitors “leflunomide” and “teriflunomide” in Covid-19: A narrative review	28
Hesperetin derivative-16 attenuates CCl4-induced inflammation and liver fibrosis by activating AMPK/SIRT3 pathway	28
PPAR-gamma agonists: Potential modulators of autophagy in obesity	28
The effect of metformin on indomethacin-induced gastric ulcer: Involvement of nitric oxide/Rho kinase pathway	28
Protective effects of hydroxy-α-sanshool from the pericarp of Zanthoxylum bungeanum Maxim. On D-galactose/AlCl3-induced Alzheimer's disease-like mice via Nrf2/HO-1 signaling pathways	28
Screening Malaria-box compounds to identify potential inhibitors against SARS-CoV-2 Mpro, using molecular docking and dynamics simulation studies	28
Dimethyl fumarate: A review of preclinical efficacy in models of neurodegenerative diseases	28
Regulatory effects of IL-1β in the interaction of GBM and tumor-associated monocyte through VCAM-1 and ICAM-1	28
A comprehensive review on potential therapeutics interventions for COVID-19	28
Unravelling high-affinity binding compounds towards transmembrane protease serine 2 enzyme in treating SARS-CoV-2 infection using molecular modelling and docking studies	28
Gypenoside XVII alleviates early diabetic retinopathy by regulating Müller cell apoptosis and autophagy in db/db mice	28
ADMET profile and virtual screening of plant and microbial natural metabolites as SARS-CoV-2 S1 glycoprotein receptor binding domain and main protease inhibitors	28
Molecular mechanisms of bufadienolides and their novel strategies for cancer treatment	28
The distinct roles of exosomes in innate immune responses and therapeutic applications in cancer	28
Interferon therapy in patients with SARS, MERS, and COVID-19: A systematic review and meta-analysis of clinical studies	28
Synergistic potential of dual andrographolide and melatonin targeting of metastatic colon cancer cells: Using the Chou-Talalay combination index method	28
Ponatinib-induced ischemic stroke in larval zebrafish for drug screening	27
Salidroside attenuates CoCl2-simulated hypoxia injury in PC12 cells partly by mitochondrial protection	27
Azithromycin: Immunomodulatory and antiviral properties for SARS-CoV-2 infection	27
Breast milk MSCs upregulated β-cells PDX1, Ngn3, and PCNA expression via remodeling ER stress /inflammatory /apoptotic signaling pathways in type 1 diabetic rats	27
Mechanisms underlying paclitaxel-induced neuropathic pain: Channels, inflammation and immune regulations	27

The involvement of epithelial-to-mesenchymal transition in doxorubicin resistance: Possible molecular targets	27
Gut microbiota modulation as a promising therapy with metformin in rats with non-alcoholic steatohepatitis: Role of LPS/TLR4 and autophagy pathways	27
Neuroprotective effects of vildagliptin on drug induced Alzheimer's disease in rats with metabolic syndrome: Role of hippocampal klotho and AKT signaling pathways	27
Antidepressant mechanism of catalpol: Involvement of the PI3K/Akt/Nrf2/HO-1 signaling pathway in rat hippocampus	27
Combination of ponatinib with deferoxamine synergistically mitigates ischemic heart injury via simultaneous prevention of necroptosis and ferroptosis	27
Self-propelled micro/nanobots: A new insight into precisely targeting cancerous cells through intelligent and deep cancer penetration	27
Off-label use of chloroquine, hydroxychloroquine, azithromycin and lopinavir/ritonavir in COVID-19 risks prolonging the QT interval by targeting the hERG channel	26
Quercetin protects against LPS-induced lung injury in mice via SIRT1-mediated suppression of PKM2 nuclear accumulation	26
Involvement of nitric oxide pathway in the anti-inflammatory effect of modafinil on indomethacin-, stress-, and ethanol -induced gastric mucosal injury in rat	26
Ameliorative effects of chlorogenic acid on alcoholic liver injury in mice via gut microbiota informatics	26
Macrophage responses associated with COVID-19: A pharmacological perspective	26
Attenuation of neurobehavioural abnormalities by papaverine in prenatal valproic acid rat model of ASD	26
Coronavirus diseases 2019: Current biological situation and potential therapeutic perspective	26
Carvacrol alleviates liver fibrosis by inhibiting TRPM7 and modulating the MAPK signaling pathway	26
Role of AMP-activated protein kinase on cardio-metabolic abnormalities in the development of diabetic cardiomyopathy: A molecular landscape	26
Arctigenin, an anti-tumor agent; a cutting-edge topic and up-to-the-minute approach in cancer treatment	26
Quercetin reduces inflammation in a rat model of diabetic peripheral neuropathy by regulating the TLR4/MyD88/NF-κB signalling pathway	26
Effects of gut microbiota on atherosclerosis through hydrogen sulfide	26
Targeting autophagy to modulate hepatic ischemia/reperfusion injury: A comparative study between octreotide and melatonin as autophagy modulators through AMPK/PI3K/AKT/mTOR/ULK1 and Keap1/Nrf2 signali	26
Apoptotic neurons and amyloid-beta clearance by phagocytosis in Alzheimer's disease: Pathological mechanisms and therapeutic outlooks	26
Combining naringenin and metformin with doxorubicin enhances anticancer activity against triple-negative breast cancer in vitro and in vivo	25
Bazedoxifene exhibits anti-inflammation and anti-atherosclerotic effects via inhibition of IL-6/IL-6R/STAT3 signaling	25
JNK signaling pathway in metabolic disorders: An emerging therapeutic target	25
Therapeutic potential and molecular mechanisms of mycophenolic acid as an anticancer agent	25
The recent advances of PD-1 and PD-L1 checkpoint signaling inhibition for breast cancer immunotherapy	25
Oleanolic acid exerts neuroprotective effects in subarachnoid hemorrhage rats through SIRT1-mediated HMGB1 deacetylation	25
Malvidin protects against lipopolysaccharide-induced acute liver injury in mice via regulating Nrf2 and NLRP3 pathways and suppressing apoptosis and autophagy	25
Role of pyroptosis in diabetic retinopathy and its therapeutic implications	25
Acteoside exerts neuroprotection effects in the model of Parkinson's disease via inducing autophagy: Network pharmacology and experimental study	25
Emodin in atherosclerosis prevention: Pharmacological actions and therapeutic potential	25
The expression profile and role of non-coding RNAs in obesity	25
Ginsenoside Rg3 exerts a neuroprotective effect in rotenone-induced Parkinson's disease mice via its anti-oxidative properties	25
P2X7 receptor in multifaceted cellular signalling and its relevance as a potential therapeutic target in different diseases	25
Sinomenine ameliorates septic acute lung injury in mice by modulating gut homeostasis via aryl hydrocarbon receptor/Nrf2 pathway	25
Enhanced targeting of 3D pancreatic cancer spheroids by aptamer-conjugated polymeric micelles with deep tumor penetration	25
Cannabidiol protects against Alzheimer's disease in C. elegans via ROS scavenging activity of its phenolic hydroxyl groups	25
Kaempferol inhibits benign prostatic hyperplasia by resisting the action of androgen	25
Morin attenuates memory deficits in a rat model of Alzheimer's disease by ameliorating oxidative stress and neuroinflammation	25
COVID-19 infection and nanomedicine applications for development of vaccines and therapeutics: An overview and future perspectives based on polymersomes	25
Renin-angiotensin system at the interface of COVID-19 infection	24
Strategies for active tumor targeting-an update	24
Kaempferol acts on bile acid signaling and gut microbiota to attenuate the tumor burden in ApcMin/+ mice	24
Astragaloside IV mitigates cerebral ischaemia-reperfusion injury via inhibition of P62/Keap1/Nrf2 pathway-mediated ferroptosis	24
COVID-19 associated complications and potential therapeutic targets	24
Hegemony of inflammation in atherosclerosis and coronary artery disease	24
Gliclazide alters macrophages polarization state in diabetic atherosclerosis in vitro via blocking AGE-RAGE/TLR4-reactive oxygen species-activated NF-kβ nexus	24
Pharmacological significance of extra-oral taste receptors	24
MiRNA-138–5p: A strong tumor suppressor targeting PD-L-1 inhibits proliferation and motility of breast cancer cells and induces apoptosis	24
Can selective serotonin reuptake inhibitors have a neuroprotective effect during COVID-19?	24
Gut commensal-derived butyrate reverses obesity-induced social deficits and anxiety-like behaviors via regulation of microglial homeostasis	24
Molecular targets of statins and their potential side effects: Not all the glitter is gold	24
Emodin accelerates diabetic wound healing by promoting anti-inflammatory macrophage polarization	24
The mechanism of the imbalance between proliferation and ferroptosis in pulmonary artery smooth muscle cells based on the activation of SLC7A11	24
The progression of pulmonary arterial hypertension induced by monocrotaline is characterized by lung nitrosative and oxidative stress, and impaired pulmonary artery reactivity	23
Evaluation of Th1 and Th2 mediated cellular and humoral immunity in patients with COVID-19 following the use of melatonin as an adjunctive treatment	23
SIRT1/PGC-1α signaling activation by mangiferin attenuates cerebral hypoxia/reoxygenation injury in neuroblastoma cells	23
Astaxanthin alleviates neuropathic pain by inhibiting the MAPKs and NF-κB pathways	23
NLRP3 inflammasomes: A potential target to improve mitochondrial biogenesis in Parkinson's disease	23
Eriodictyol inhibits glioblastoma migration and invasion by reversing EMT via downregulation of the P38 MAPK/GSK-3β/ZEB1 pathway	23
Assessment of the role of non-coding RNAs in the pathophysiology of Parkinson's disease	23
Effect of anti-hyperglycemic drugs on endoplasmic reticulum (ER) stress in human coronary artery endothelial cells	23
Genistein protects epilepsy-induced brain injury through regulating the JAK2/STAT3 and Keap1/Nrf2 signaling pathways in the developing rats	23
Duchenne muscular dystrophy: Current treatment and emerging exon skipping and gene therapy approach	23
Protocatechualdehyde protects oxygen-glucose deprivation/reoxygenation-induced myocardial injury via inhibiting PERK/ATF6α/IRE1α pathway	23
The bacterial thiopeptide thiostrepton. An update of its mode of action, pharmacological properties and applications	23
Eucalyptol prevents bleomycin-induced pulmonary fibrosis and M2 macrophage polarization	22
Concomitant use of analgesics and immune checkpoint inhibitors in non-small cell lung cancer: A pharmacodynamics perspective	22
Glucagon-like peptide-1 cleavage product GLP-1(9–36) reduces neuroinflammation from stroke via the activation of insulin-like growth factor 1 receptor in astrocytes	22
Recent advances in immune checkpoint therapy in non-small cell lung cancer and opportunities for nanoparticle-based therapy	22
ALKBH5 ameliorated liver fibrosis and suppressed HSCs activation via triggering PTCH1 activation in an m6A dependent manner	22
lncRNA BBOX1-AS1 silencing inhibits esophageal squamous cell cancer progression by promoting ferroptosis via miR-513a-3p/SLC7A11 axis	22
Gastrodin alleviates perioperative neurocognitive dysfunction of aged mice by suppressing neuroinflammation	22
Quercetin and piperine enriched nanostructured lipid carriers (NLCs) to improve apoptosis in oral squamous cellular carcinoma (FaDu cells) with improved biodistribution profile	22
Novel SREBP1 inhibitor cinobufotalin suppresses proliferation of hepatocellular carcinoma by targeting lipogenesis	22
Dapagliflozin attenuates steatosis in livers of high-fat diet-induced mice and oleic acid-treated L02 cells via regulating AMPK/mTOR pathway	22
microRNA-181a mediates the chemo-sensitivity of glioblastoma to carmustine and regulates cell proliferation, migration, and apoptosis	22
Sodium butyrate alleviates cholesterol gallstones by regulating bile acid metabolism	22
Isorhamnetin promotes functional recovery in rats with spinal cord injury by abating oxidative stress and modulating M2 macrophages/microglia polarization	22
Therapeutic potential of p53 reactivation in prostate cancer: Strategies and opportunities	22
Computational drug re-purposing targeting the spike glycoprotein of SARS-CoV-2 as an effective strategy to neutralize COVID-19	22
Diosgenin attenuates tumor growth and metastasis in transgenic prostate cancer mouse model by negatively regulating both NF-κB/STAT3 signaling cascades	22
Targeting pivotal inflammatory pathways in COVID-19: A mechanistic review	22
Antidepressant effects of curcumin-coated iron oxide nanoparticles in a rat model of depression	22
Gender-specific approach in psychiatric diseases: Because sex matters	22
Pirfenidone is a renal protective drug: Mechanisms, signalling pathways, and preclinical evidence	22
A brief review of urate transporter 1 (URAT1) inhibitors for the treatment of hyperuricemia and gout: Current therapeutic options and potential applications	22
Cardio-protective effect of tetrahydrocurcumin, the primary hydrogenated metabolite of curcumin in vivo and in vitro: Induction of apoptosis and autophagy via PI3K/AKT/mTOR pathways	22
Remodeling of microbiota gut-brain axis using psychobiotics in depression	22
Targeting HMGB1/TLR4/NF-κB signaling pathway by protocatechuic acid protects against l-arginine induced acute pancreatitis and multiple organs injury in rats	22
Baicalin ameliorates CUMS-induced depression-like behaviors through activating AMPK/PGC-1α pathway and enhancing NIX-mediated mitophagy in mice	22
Eurocristatine, a plant alkaloid from Eurotium cristatum, alleviates insulin resistance in db/db diabetic mice via activation of PI3K/AKT signaling pathway	21
Mechanistic evaluation of a novel cyclohexenone derivative’s functionality against nociception and inflammation: An in-vitro, in-vivo and in-silico approach	21
Deep learning and machine intelligence: New computational modeling techniques for discovery of the combination rules and pharmacodynamic characteristics of Traditional Chinese Medicine	21
Immunomodulatory effect of protocatechuic acid on cyclophosphamide induced brain injury in rat: Modulation of inflammosomes NLRP3 and SIRT1	21
Amelioration of testosterone-induced benign prostatic hyperplasia using febuxostat in rats: The role of VEGF/TGFβ and iNOS/COX-2	21