European Journal of Pharmacology

Article	Citations
Orofacial pain models induce impairment in spatial learning and working memory in rodents: A systematic review and meta-analysis	271
Molecular interplay between EIF4 family and circular RNAs in cancer: Mechanisms and therapeutics	172
Inverse agonism of lysophospholipids with cationic head groups at Gi-coupled receptor GPR82	139
Vanin1 (VNN1) in chronic diseases: Future directions for targeted therapy	115
Editorial Board	111
Amorphous selenium nanodots alleviate non-alcoholic fatty liver disease via activating VEGF receptor 1 to further inhibit phosphorylation of JNK/p38 MAPK pathways	102
Editorial Board	101
Eukaryotic elongation factor 2 kinase inhibitor, A484954 inhibits perivascular sympathetic nerve stimulation-induced vasoconstriction in isolated renal artery	99
Editorial Board	92
Phosphodiesterase-1 inhibitor modulates Ca2+ regulation in sirtuin 1-deficient mouse cardiomyocytes	90
Editorial Board	88
RNAi in psoriasis: A melodic exploration of miRNA, shRNA, and amiRNA with a spotlight on siRNA	77
Melittin suppresses aerobic glycolysis by regulating HSF1/PDK3 to increase chemosensitivity of NSCLC	75
Corrigendum to “Guggulsterone inhibits migration and invasion through proteasomal and lysosomal degradation in human glioblastoma cells” [Eur. J. Pharmacol. 938 (2023) 175411]	73
Validation and characterization of oxycodone physical dependence in C57BL/6J mice	72
Corrigendum to “Isopropyl 3-(3, 4-dihydroxyphenyl)-2-hydroxypropanoate protects lipopolysaccharide-induced acute lung injury in mice by attenuating pyroptosis” [Eur. J. Pharmacol. 5 (2023) 175545]	69
Comprehensive characterization of fatty acid oxidation in triple-negative breast cancer: Focus on biological roles and drug modulation	66
Nanomedicine: A great boon for cardiac regenerative medicine	65
HSP90: A promising target for NSCLC treatments	65
Inclusion of the in-chain sulfur in 3-thiaCTU increases the efficiency of mitochondrial targeting and cell killing by anticancer aryl-urea fatty acids	62
Autophagic inhibitor ROC-325 ameliorates glomerulosclerosis and podocyte injury via inhibiting autophagic flux in experimental FSGS mice	62
Effects of chronic mirabegron treatment on metabolic and cardiovascular parameters as well as on atherosclerotic lesions of WHHL rabbits with high-fructose high-fat diet-induced insulin resistance.	62
Sacubitril/valsartan in chronic kidney disease: From pharmacological mechanism to clinical application	60
Ginsenoside Rg1 promotes fetal hemoglobin production in vitro: A potential therapeutic avenue for β-thalassemia	57
The synergistic effects of opioid and neuropeptide B/W in rat acute inflammatory and neuropathic pain models	56

Inhibition of TRPC3 channels suppresses seizure susceptibility in the genetically-epilepsy prone rats	56
Combining brief recall and ketamine treatment prevents stress-primed methamphetamine memory reinstatement via heightening mPFC GABA activity	56
Corosolic acid attenuates platelet-derived growth factor signaling in macrophages and smooth muscle cells of pulmonary arterial hypertension	56
Suppression of hypoxia-induced CAV1 autophagic degradation enhances nanoalbumin-paclitaxel transcytosis and improves therapeutic activity in pancreatic cancer	55
Novel combinatorial autophagy inhibition therapy for triple negative breast cancers	54
Validating the temporal performance of genetic biomarkers in an animal model of recurrence/ non-recurrence myocardial infarction persuades by bioinformatics tools	54
3,3′-O-dimethylquercetin: A bi-functional vasodilator isolated from green propolis of the Caatinga Mimosa tenuiflora	53
IL-1 receptor-associated kinase family proteins: An overview of their role in liver disease	52
Inhibiting PRMT1 protects against CoNV by regulating macrophages through the FGF2/PI3K/Akt pathway	52
Molecular mechanism and therapeutic significance of dihydromyricetin in nonalcoholic fatty liver disease	51
Cyclin-dependent kinase 5 inhibitor attenuates lipopolysaccharide-induced neuroinflammation through metabolic reprogramming	51
Efficacy of the neurotensin receptor 1 analog PD149163 in modulation of the kidney inflammation: Inhibition of the nuclear factor kappa β signaling pathway and oxidative stress in endotoxemic mice	50
Current progress on the mechanisms of hyperhomocysteinemia-induced vascular injury and use of natural polyphenol compounds	50
Characterisation of bis(4-aminoquinoline)s as α1A adrenoceptor allosteric modulators	49
TNF-alpha mediates airway hyperreactivity in silicotic mice: Effect of thalidomide treatment	49
Suppression of hippocampal GABAergic transmission impairs memory in rodent models of Alzheimer's disease	48
Risperidone impedes glutamate excitotoxicity in a valproic acid rat model of autism: Role of ADAR2 in AMPA GluA2 RNA editing	47
Advancing health care via artificial intelligence: From concept to clinic	47
Antagonizing interleukin-5 receptor ameliorates dextran sulfate sodium-induced experimental colitis in mice through reducing NLRP3 inflammasome activation	47
Phloretin and Enalapril co-administration ameliorates hyperglycemia mediated exacerbation of myocardial injury in rats	46
Isorhynchophylline ameliorates the progression of osteoarthritis by inhibiting the NF-κB pathway	46
Low-intensity pulsed ultrasound prevents angiotensin II-induced aortic smooth muscle cell phenotypic switch via hampering miR-17-5p and enhancing PPAR-γ	46
Protective effect of 5,6,7,8-Tetrahydroxyflavone on high altitude cerebral edema in rats	45
Hydrogen sulfide ameliorates hypertension and vascular dysfunction induced by insulin resistance in rats by reducing oxidative stress and activating eNOS	45
Long non-coding RNA MALAT1 modulates myocardial ischemia-reperfusion injury through the PI3K/Akt/eNOS pathway by sponging miRNA-133a-3p to target IGF1R expression	44
Protein detection and localization of the non-selective cation channel TRPC6 in the human heart	44
Abaloparatide: A review of preclinical and clinical studies	44
GPR146 regulates pulmonary vascular remodeling by promoting pulmonary artery smooth muscle cell proliferation through 5-lipoxygenase	43
Small molecule CGRP receptor antagonists for the preventive treatment of migraine: A review	42
PI3K/mTOR dual-inhibition with VS-5584 enhances anti-leukemic efficacy of ponatinib in blasts and Ph-negative LSCs of chronic myeloid leukemia	42
The antidiabetic drug teneligliptin induces vasodilation via activation of PKG, Kv channels, and SERCA pumps in aortic smooth muscle	42
Hesperetin ameliorates spinal cord injury in rats through suppressing apoptosis, oxidative stress and inflammatory response	42
Novel SREBP1 inhibitor cinobufotalin suppresses proliferation of hepatocellular carcinoma by targeting lipogenesis	41
Integrating network pharmacology, transcriptomics, and molecular simulation to reveal the mechanism of tert-butylhydroquinone for treating diabetic retinopathy	41
Metformin alleviates glucolipotoxicity-induced pancreatic β cell ferroptosis through regulation of the GPX4/ACSL4 axis	41
Effects of oleanolic acid and ursolic acid on depression-like behaviors induced by maternal separation in mice	40
Compound Z526 alleviates chemotherapy-induced cachectic muscle loss by ameliorating oxidative stress-driven protein metabolic imbalance and apoptosis	40
Inhibition of intraflagellar transport protein-88 promotes epithelial-to-mesenchymal transition and reduces cardiac remodeling post-myocardial infarction	40
Nitisinone attenuates cartilage degeneration and subchondral osteoclastogenesis in osteoarthritis and concomitantly inhibits the cGAS/STING/NF-κB pathway	39
A comprehensive review of targeting RAF kinase in cancer	39
Evodiamine impairs HIF1A histone lactylation to inhibit Sema3A-mediated angiogenesis and PD-L1 by inducing ferroptosis in prostate cancer	39
Ginsenoside Rb1 promotes the activation of PPARα pathway via inhibiting FADD to ameliorate heart failure	39
Astragaloside IV mitigates cerebral ischaemia-reperfusion injury via inhibition of P62/Keap1/Nrf2 pathway-mediated ferroptosis	38
Dehydrocostuslactone attenuated oxygen and glucose deprivation/reperfusion-induced PC12 cell injury through inhibition of apoptosis and autophagy by activating the PI3K/AKT/mTOR pathway	38
Preventive effects of (−) epicatechin on tachycardia, cardiac hypertrophy, and nuclear factor- κB inflammatory signaling pathway in isoproterenol-induced myocardial infarcted rats	38
Ghrelin alleviates placental dysfunction by down-regulating NF-κB phosphorylation in LPS-induced rat model of preeclampsia	38
Dopamine agonists versus levodopa monotherapy in early Parkinson's disease for the potential risks of motor complications: A network meta-analysis	38
Small-molecule targeting PKM2 provides a molecular basis of lactylation-dependent fibroblast-like synoviocytes proliferation inhibition against rheumatoid arthritis	37
Significance of NMDA receptor-targeting compounds in neuropsychological disorders: An In-depth Review	37
Role of 11β-hydroxysteroid dehydrogenase type 1 inhibition in the antiobesity effect of J2H-1702 on adipocytes and a high-fat diet-induced NASH model	37

Editorial Board	36
Deciphering TGF-β1's role in drug resistance and leveraging plant bioactives for cancer therapy	36
Tenacissoside H repressed the progression of glioblastoma by inhibiting the PI3K/Akt/mTOR signaling pathway	36
Dihydrotanshinone I improves cardiac function by promoting lymphangiogenesis after myocardial ischemia-reperfusion injury	35
Dankasterone A induces prostate cancer cell death by inducing oxidative stress	35
Transcription factor EB protects against endoplasmic reticulum stress in human coronary artery endothelial cells	35
Manzamine A: A promising marine-derived cancer therapeutic for multi-targeted interactions with E2F8, SIX1, AR, GSK-3β, and V-ATPase - A systematic review	35
Aucubin supplementation alleviate diabetes induced-disruption of blood-testis barrier and testicular damage via stabilizing cell junction integrity	35
Up-regulated ITGB4 promotes hepatocellular carcinoma metastasis by activating hypoxia-mediated glycolysis and cancer-associated fibroblasts	35
Editorial Board	35
The key roles of non-coding RNAs in the pathophysiology of hypertension	34
Trilobatin alleviates non-alcoholic fatty liver disease in high-fat diet plus streptozotocin-induced diabetic mice by suppressing NLRP3 inflammasome activation	34
Emerging roles of dehydrogenase/reductase member 2 (DHRS2) in the pathology of disease	34
Naproxen as a potential candidate for promoting rivastigmine anti-Alzheimer activity against aluminum chloride-prompted Alzheimer's-like disease in rats; neurogenesis and apoptosis modulation as a pos	34
Crosstalk between endothelial cells with a non-canonical EndoMT phenotype and cardiomyocytes/fibroblasts via IGFBP5 aggravates TAC-induced cardiac dysfunction	34
Astragalus polysaccharide attenuates bleomycin-induced pulmonary fibrosis by inhibiting TLR4/ NF-κB signaling pathway and regulating gut microbiota	34
Demyelination in cuprizone mice is ameliorated by calycosin mediated through astrocyte Nrf2 signaling pathway	34
Ginkgolide A alleviates cardiac remodeling in mice with myocardial infarction via binding to matrix metalloproteinase-9 to attenuate inflammation	34
Potential of Orlistat to induce apoptotic and antiangiogenic effects as well as inhibition of fatty acid synthesis in breast cancer cells	34
Dioscin alleviates lung ischemia/reperfusion injury by regulating FXR-mediated oxidative stress, apoptosis, and inflammation	34
PI3K/Akt/GSK-3β signal pathway is involved in P2X7 receptor-induced proliferation and EMT of colorectal cancer cells	34
Poncirin ameliorates cardiac ischemia-reperfusion injury by activating PI3K/AKT/PGC-1α signaling	34
Potential role of remimazolam in alleviating bone cancer pain in mice via modulation of translocator protein in spinal astrocytes	33
Inhibition of abnormally activated HIF-1α-GLUT1/3-glycolysis pathway enhances the sensitivity of hepatocellular carcinoma to 5-caffeoylquinic acid and its derivatives	33
Sodium houttuyfonate protects against cardiac injury by regulating cardiac energy metabolism in diabetic rats	33
Drug repurposing: An emerging strategy in alleviating skin cancer	33
Trigeminal neuropathic pain reduces 50-kHz ultrasonic vocalizations in rats, which are restored by analgesic drugs	33
Mutation of valine 53 at the interface between extracellular and transmembrane domains of the β2 principal subunit affects the GABAA receptor gating	32
Cycloheptylprodigiosin from marine bacterium Spartinivicinus ruber MCCC 1K03745T induces a novel form of cell death characterized by Golgi disruption and enhanced secretion of cathepsin D in non-small	32
Recent trends in diabetic wound healing with nanofibrous scaffolds	32
Face validation and pharmacologic analysis of Sik3 mutant mouse as a possible model of idiopathic hypersomnia	32
Pregabalin can interact synergistically with Kv7 channel openers to exert antinociception in mice	31
Effects of cannabinoid agonists and antagonists in male rats discriminating the synthetic cannabinoid AM2201	31
Galangin ameliorates osteoarthritis progression by attenuating extracellular matrix degradation in chondrocytes via the activation of PRELP expression	31
Effects of intranasal azithromycin on features of cigarette smoke-induced lung inflammation	31
A novel Toll-like receptor 7/8–specific antagonist E6742 ameliorates clinically relevant disease parameters in murine models of lupus	31
Protective effects of 5(S)-5-carboxystrictosidine on myocardial ischemia-reperfusion injury through activation of mitochondrial KATP channels	31
Human umbilical cord-derived stem cell sheets improve left ventricular function in rat models of ischemic heart failure	31
Pirfenidone improves voiding function by suppressing bladder fibrosis in underactive bladder rats	31
Hypoxia activates GPR146 which participates in pulmonary vascular remodeling by promoting pyroptosis of pulmonary artery endothelial cells	31
High-throughput screening of the natural STK11 agonist dauricine: A biphenylisoquinoline alkaloid exerting anti-NSCLC effects and reversing gefitinib resistance	31
Succinate level is increased and succinate dehydrogenase exerts forward and reverse catalytic activities in lipopolysaccharides-stimulated cardiac tissue: The protective role of dimethyl malonate	31
Carvacrol alleviates liver fibrosis by inhibiting TRPM7 and modulating the MAPK signaling pathway	30
Research progress in use of traditional Chinese medicine monomer for treatment of non-alcoholic fatty liver disease	30
Curcumin nicotinate decreases serum LDL cholesterol through LDL receptor-mediated mechanism	30
Tryptanthrin impairs platelet function and thrombus formation by reducing Gp1bα expression	30
Metabolic reprogramming of glutamine involved in tumorigenesis, multidrug resistance and tumor immunity	30
A BET inhibitor, NHWD-870, can downregulate dendritic cells maturation via the IRF7-mediated signaling pathway to ameliorate imiquimod-induced psoriasis-like murine skin inflammation	30
Salidroside attenuates high altitude hypobaric hypoxia-induced brain injury in mice via inhibiting NF-κB/NLRP3 pathway	30
Anti-pancreatic lipase and anti-adipogenic effects of 5,7,3′,4′,5′-pentamethoxy and 6,2′,4′-trimethoxy flavone - An in vitro study	30
Corrigendum to “Protective effects of cortex fraxini coumarines against oxonate-induced hyperuricemia and renal dysfunction in mice” [Eur. J. Pharmacol. 666 (2011) 196–204]	29
Involvement of ferroptosis in eribulin-induced cytotoxicity in ovarian clear cell carcinoma	29
Ankrd1 regulates endogenous cardiac regeneration in mice by modulating cyclin D1	29
Effects of the serotonin 5-HT1B receptor agonist CP 94253 on the locomotor activity and body temperature of preweanling and adult male and female rats	29
Editorial Board	29
Repositioning of Montelukast to inhibit proliferation of mutated KRAS pancreatic cancer through a novel mechanism that interfere the binding between KRAS and GTP/GDP	29
Sodium nitrite induces tolerance in the mouse aorta: Involvement of the renin-angiotensin system, nitric oxide synthase, and reactive oxygen species	29
Hepatitis B Virus X Protein promotes VWF-mediated HCC progression through ST8SIA6-AS1/miR-3150b-3p/ASCL1 axis	29
Alternative role of glucagon-like Peptide-1 receptor agonists in neurodegenerative diseases	29
Astragaloside IV protects against C/EBP homologous protein-mediated apoptosis in oxidized low-density lipoprotein-treated macrophages by promoting autophagy	29
Research progress on the role of orphan receptor GPR139 in neuropsychiatric behaviours	29
CRISPR/Cas9-based multiplex genome editing of BCL11A and HBG efficiently induces fetal hemoglobin expression	29
Sustained AT1R stimulation induces upregulation of growth factors in human cardiac fibroblasts via Gαq/TGF-β/ERK signaling that influences myocyte hypertrophy	28
siRNA: Mechanism of action, challenges, and therapeutic approaches	28
Antidepressant-like effect of sodium orthovanadate in a mouse model of chronic unpredictable mild stress	28
Hypoxia-inducible factor-1: Regulatory mechanisms and drug therapy in myocardial infarction	28
Interferon therapy in patients with SARS, MERS, and COVID-19: A systematic review and meta-analysis of clinical studies	28
Quercetin and piperine enriched nanostructured lipid carriers (NLCs) to improve apoptosis in oral squamous cellular carcinoma (FaDu cells) with improved biodistribution profile	28
Sophoricoside ameliorates cerebral ischemia-reperfusion injury dependent on activating AMPK	28
Valdecoxib blocks rat TRPV2 channels	28
Oncolytic viruses as emerging therapy against cancers including Oncovirus-induced cancers	28
Pirfenidone and nintedanib attenuates pulmonary artery endothelial and smooth muscle cells transformations induced by IL-11	28
Ginsenoside Rd attenuates myocardial ischemia injury through improving mitochondrial biogenesis via WNT5A/Ca2+ pathways	28
Tumoral EIF4EBP1 regulates the crosstalk between tumor-associated macrophages and tumor cells in MRTK	28
LncRNAS—modulators of neurovascular units in diabetic retinopathy	28
Anti-cancer impact of Hypericin in B-CPAP cells: Extrinsic caspase dependent apoptosis induction and metastasis obstruction	28
Stabilization of mitochondrial function by chlorogenic acid protects against kainic acid-induced seizures and neuronal cell death in rats	27
Asiatic acid protects articular cartilage through promoting chondrogenesis and inhibiting inflammation and hypertrophy in osteoarthritis	27
Advanced dressings based on novel biological targets for diabetic wound healing: A review	27
Inhibition of CHIT1 as a novel therapeutic approach in idiopathic pulmonary fibrosis	27

Targets, trials and tribulations in Alzheimer therapeutics	27
LncRNA DANCR deficiency promotes high glucose-induced endothelial to mesenchymal transition in cardiac microvascular cells via the FoxO1/DDAH1/ADMA signaling pathway	27
Lapatinib ditosylate rescues motor deficits in rotenone-intoxicated rats: Potential repurposing of anti-cancer drug as a disease-modifying agent in Parkinson's disease	27
Genkwanin blocks the interaction between phosphorylated JNK and NFATc1 to promote osteogenic differentiation and collagen Ⅰ α1 production	27
Kurarinone induced p53-independent G0/G1 cell cycle arrest by degradation of K-RAS via WDR76 in human colorectal cancer cells	27
Biochanin A inhibits excitotoxicity-triggered ferroptosis in hippocampal neurons	27
Cancer chemotherapy resistance: Mechanisms and recent breakthrough in targeted drug delivery	27
Influence of adrenalectomy on the gut microbiome and MDMA-induced hyperthermia	27
Comparative efficacy and acceptability of drug treatments for Parkinson’s disease with depression: A systematic review with network meta-analysis	27
Recent advancements in targeting the immune system to treat hypertension	27
Anticancer activity and metabolic alteration in colon and prostate cancer cells by novel moxifloxacin conjugates with fatty acids	26
Effects of proprotein convertase subtilisin-kexin type 9 inhibitors on inflammatory and hemostatic parameters in post myocardial infarction patients	26
Editorial Board	26
Cancer-associated fibroblasts (CAFs) and tumor-associated macrophages (TAMs); where do they stand in tumorigenesis and how they can change the face of cancer therapy?	26
Editorial Board	26
New insights on the differential interaction of sulfiredoxin with members of the peroxiredoxin family revealed by protein-protein docking and experimental studies	26
Synergism of small molecules targeting VDAC with sorafenib, regorafenib or lenvatinib on hepatocarcinoma cell proliferation and survival	26
Dose-dependent opposite effects of nortriptyline on affective-like behavior in adolescent rats: Comparison with adult rats	26
Synthetic flavokawain analog (E)-1-(2′-hydroxy-4′,6′-dimethoxyphenyl)-3-(3-methoxy-4-(3-morpholinopropoxy)phenyl)prop-2-en-1-one (FK-morph) effectively regresses endometriotic implants in rats	26
Overexpressed mitogen-and stress-activated protein kinase 1 promotes the resistance of cytarabine in acute myeloid leukemia through brahma related gene 1-mediated upregulation of heme oxygenase-1	26
Alpha1B-adreneroceptor is involved in norepinephrine-induced pulmonary artery smooth muscle cell proliferation via p38 signaling	26
Sodium houttuyfonate: A review of its antimicrobial, anti-inflammatory and cardiovascular protective effects	26
Editorial Board	25
Novel prospects in targeting neurodegenerative disorders via autophagy	25
Complementary effects of dapagliflozin and lobeglitazone on metabolism in a diet-induced obese mouse model	25
Integrated network pharmacology and molecular docking analyses of the mechanisms underlying the antihypertensive effects of lotusine	25
Esketamine improves cognitive function in sepsis-associated encephalopathy by inhibiting microglia-mediated neuroinflammation	25
PAI-1 siRNA-loaded biomimetic nanoparticles for ameliorating diminished ovarian reserve and inhibiting ovarian fibrosis	25
lncRNA BBOX1-AS1 silencing inhibits esophageal squamous cell cancer progression by promoting ferroptosis via miR-513a-3p/SLC7A11 axis	25
GW501516 facilitated tumor immune escape by inhibiting phagocytosis	25
Effect of hyperoside on osteoporosis in ovariectomized mice through estrogen receptor α/ITGβ3 signaling pathway	25
Beyond chemotherapy: Exploring 5-FU resistance and stemness in colorectal cancer	25
The role of kappa opioid receptors in immune system – An overview	25
Emerging therapeutic avenues in cardiac amyloidosis	25
Pharmacogenetics of angiotensin-converting enzyme inhibitors (ACEI) and angiotensin II receptor blockers (ARB) in cardiovascular diseases	25
Acteoside exerts neuroprotection effects in the model of Parkinson's disease via inducing autophagy: Network pharmacology and experimental study	24
Tulipalin A suppressed the pro-inflammatory polarization of M1 macrophage and mitigated the acute lung injury in mice via interference DNA binding activity of NF-κB	24
Gut commensal-derived butyrate reverses obesity-induced social deficits and anxiety-like behaviors via regulation of microglial homeostasis	24
Curcumol suppresses endothelial-to-mesenchymal transition via inhibiting the AKT/GSK3β signaling pathway and alleviates pulmonary arterial hypertension in rats	24
Immunomodulatory role of Nanocurcumin in COVID-19 patients with dropped natural killer cells frequency and function	24
Improving chimeric antigen receptor T-cell therapies by using artificial intelligence and internet of things technologies: A narrative review	24
Phosphatidic acid as a cofactor of mTORC1 in platinum-based chemoresistance: Mechanisms and therapeutic potential	24
LncRNA MEG3 reverses CCl4-induced liver fibrosis by targeting NLRC5	24
Biopharmaceuticals against substance use disorders – Present and future	24
JAK2/STAT3 as a new potential target to manage neurodegenerative diseases: An interactive review	24
BRD4 as a therapeutic target for atrial fibrosis and atrial fibrillation	24
MitoTEMPO protects against podocyte injury by inhibiting NLRP3 inflammasome via PINK1/Parkin pathway-mediated mitophagy	24
Omega-3 fatty acids prevent nicotine withdrawal-induced exacerbation of anxiety and depression by affecting oxidative stress balance, inflammatory response, BDNF and serotonin metabolism in rats	24
Fumarate and its downstream signalling pathways in the cardiorenal system: Recent insights and novel expositions in the etiology of hypertension	24
Repurposing old molecules for new indications: Defining pillars of success from lessons in the past	24
IGF2/IGF2R/Sting signaling as a therapeutic target in DSS-induced ulcerative colitis	23
Inhibition of MALT1 reduces ferroptosis in rat hearts following ischemia/reperfusion via enhancing the Nrf2/SLC7A11 pathway	23
Perturbation of Ca2+ stores and store-operated Ca2+ influx by lidocaine in neuronal N2A and NG108-15 cells	23
Hinokitiol protects gastric injury from ethanol exposure via its iron sequestration capacity	23
Cyanidin-3-O-glucoside and its derivative vitisin A alleviate androgenetic alopecia by exerting anti-androgen effect and inhibiting dermal papilla cell apoptosis	23
Imperatorin attenuates CCl4-induced cirrhosis and portal hypertension by improving vascular remodeling and profibrogenic pathways	23
Simultaneous nanocarrier-mediated delivery of siRNAs and chemotherapeutic agents in cancer therapy and diagnosis: Recent advances	23
Investigating the mechanism of ferroptosis induction by sappanone A in hepatocellular carcinoma: NRF2/xCT/GPX4 axis	23
Activation of alpha7 nicotinic acetylcholine receptor protects bovine endometrial tissue against LPS-induced inflammatory injury via JAK2/STAT3 pathway and COX-2 derived prostaglandin E2	23
FGF17 protects cerebral ischemia reperfusion-induced blood-brain barrier disruption via FGF receptor 3-mediated PI3K/AKT signaling pathway	23
Carbon monoxide attenuates cellular senescence-mediated pulmonary fibrosis via modulating p53/PAI-1 pathway	23
Exploring the mechanism of α-Bisabolol in the treatment of psoriasis based on network pharmacology and experimental validation	23
Tenovin-1 inhibited dengue virus replication through SIRT2	23
Development of a novel Poly (I:C)-induced murine model with accelerated lupus nephritis and examination of the therapeutic effects of mycophenolate mofetil and a cathepsin S inhibitor	22
Diosgenin inhibits prostate cancer progression by inducing UHRF1 protein degradation	22
Targeting TRPs in autophagy regulation and human diseases	22
A review of nardosinone for pharmacological activities	22
Novel archetype in psoriasis management bridging molecular dynamics in exploring novel therapies	22
Epac as a tractable therapeutic target	22
Purinergic ionotropic P2X7 and metabotropic glutamate mGlu5 receptors crosstalk influences pro-inflammatory conditions in microglia	22
Mesenchymal stem cells alleviate inflammatory responses through regulation of T-cell subsets	22
PARP-1 inhibitor alleviates cerebral ischemia/reperfusion injury by reducing PARylation of HK-1 and LDH in mice	22
Comparison of the effects of peficitinib and tofacitinib in the adjuvant-induced arthritis rat model	22
Synthesis of 2-(2-(4-thioxo-3H-1,2-dithiole-5-yl) phenoxy)ethyl)isoindole-1,3-thione, a novel hydrogen sulfide-releasing phthalimide hybrid, and evaluation of its activity in models of inflammatory pa	22
Protective effects of atorvastatin on testicular dysfunction and reduced sperm quality induced by high-fat diet in mice: The inhibitory mechanism of oxidative stress	22
Kaempferol inhibits benign prostatic hyperplasia by resisting the action of androgen	22
Sappanone A ameliorated imiquimod-induced psoriasis-like dermatitis in BALB/c mice via suppressing Mmp8 expression and IL-17 signaling pathway	22
Comprehensive analysis of transcriptomics and metabolomics to illustrate the underlying mechanism of helenalin against hepatic fibrosis	21
Effects of 101BHG-D01, a novel M receptor antagonism, on allergic rhinitis in animal models and its mechanism	21
The endocrine disruptor vinclozolin causes endothelial injury via eNOS/Nox4/IRE1α signaling	21
MCPIP1 regulates focal adhesion kinase and Rho GTPase-dependent migration in clear cell renal cell carcinoma	21
Dehydrozingerone alleviates pulmonary fibrosis via inhibition of inflammation and epithelial-mesenchymal transition by regulating the Wnt/β-catenin pathway	21
A peripherally restricted cannabinoid-1 receptor inverse agonist promotes insulin secretion and protects from cytokine toxicity in human pancreatic islets	21
Modulation of SIRT6 related signaling pathways of p-AKT/mTOR and NRF2/HO-1 by memantine contributes to curbing the progression of tamoxifen/HFD-induced MASH in rats	21
A novel nordihydroguaiaretic acid analog, compound 3a, alleviates acute lung injury by exerting antiapoptotic and antiinflammatory effects	21
The next frontier in multiple sclerosis therapies: Current advances and evolving targets	21
Desmopressin enhances random-pattern skin flap survival in rats: Possible role of vasopressin Type-1a and 2 receptors	21
Michael acceptor-dependent pro-oxidative intervention against angiogenesis by [6]-dehydroshogaol, a pungent constituent of ginger	21
A combination of peripherally restricted CB1 and CB2 cannabinoid receptor agonists reduces bladder afferent sensitisation in cystitis	21
Differential targeting of lysophosphatidic acid LPA1, LPA2, and LPA3 receptor signalling by tricyclic and tetracyclic antidepressants.	20
Inhibition of cyclooxygenase by blocking the reducing cosubstrate at the peroxidase site: Discovery of galangin as a novel cyclooxygenase inhibitor	20
The macamide relieves fatigue by acting as inhibitor of inflammatory response in exercising mice: From central to peripheral	20
JNK signaling pathway in metabolic disorders: An emerging therapeutic target	20
A novel Zebrafish model of Alzheimer's disease by Aluminium chloride; involving nitro-oxidative stress, neuroinflammation and cholinergic pathway	20
4′-O-methylbavachalcone alleviates ischemic stroke injury by inhibiting parthanatos and promoting SIRT3	20