European Journal of Pharmacology

Papers
(The median citation count of European Journal of Pharmacology is 4. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-09-01 to 2025-09-01.)
ArticleCitations
Editorial Board209
Editorial Board194
Editorial Board130
Corrigendum to “Guggulsterone inhibits migration and invasion through proteasomal and lysosomal degradation in human glioblastoma cells” [Eur. J. Pharmacol. 938 (2023) 175411]127
Corrigendum to “Isopropyl 3-(3, 4-dihydroxyphenyl)-2-hydroxypropanoate protects lipopolysaccharide-induced acute lung injury in mice by attenuating pyroptosis” [Eur. J. Pharmacol. 5 (2023) 175545]119
Comprehensive characterization of fatty acid oxidation in triple-negative breast cancer: Focus on biological roles and drug modulation117
Autophagic inhibitor ROC-325 ameliorates glomerulosclerosis and podocyte injury via inhibiting autophagic flux in experimental FSGS mice105
Sacubitril/valsartan in chronic kidney disease: From pharmacological mechanism to clinical application100
Inhibition of TRPC3 channels suppresses seizure susceptibility in the genetically-epilepsy prone rats97
Combining brief recall and ketamine treatment prevents stress-primed methamphetamine memory reinstatement via heightening mPFC GABA activity86
Suppression of hypoxia-induced CAV1 autophagic degradation enhances nanoalbumin-paclitaxel transcytosis and improves therapeutic activity in pancreatic cancer82
Inhibiting PRMT1 protects against CoNV by regulating macrophages through the FGF2/PI3K/Akt pathway81
Sitagliptin reduces cytokine-induced β-cell apoptosis in prediabetes: A six-month interventional study81
A comprehensive review of targeting RAF kinase in cancer79
Calycosin treats acute myocardial infarction via NLRP3 inflammasome: Bioinformatics, network pharmacology and experimental validation79
Trametinib ameliorated Adriamycin-induced podocyte injury by inhibiting METTL3 modified m6A RCAN1 RNA methylation79
TNF-alpha mediates airway hyperreactivity in silicotic mice: Effect of thalidomide treatment74
Ameliorative effect of GLP1 agonist on vascular calcification in normoglycemic aged rat aorta via miR34a/SIRT6/NRF2/HO-1 signalling pathway70
Efficacy of the neurotensin receptor 1 analog PD149163 in modulation of the kidney inflammation: Inhibition of the nuclear factor kappa β signaling pathway and oxidative stress in endotoxemic mice70
Targeting eEF2K induces oxidative stress and sensitizes cancer cells to ferroptosis induction70
Antagonizing interleukin-5 receptor ameliorates dextran sulfate sodium-induced experimental colitis in mice through reducing NLRP3 inflammasome activation68
Dihydromyricetin restores mucus hypersecretion in Air–Liquid interface cultures in COPD by targeting the SRC-MAPK signaling pathway66
Arctiin attenuated NASH by inhibiting glycolysis and inflammation via FGFR2/CSF1R signaling63
Inhibition of intraflagellar transport protein-88 promotes epithelial-to-mesenchymal transition and reduces cardiac remodeling post-myocardial infarction60
Role of 11β-hydroxysteroid dehydrogenase type 1 inhibition in the antiobesity effect of J2H-1702 on adipocytes and a high-fat diet-induced NASH model58
Orofacial pain models induce impairment in spatial learning and working memory in rodents: A systematic review and meta-analysis58
Hydrogen sulfide ameliorates hypertension and vascular dysfunction induced by insulin resistance in rats by reducing oxidative stress and activating eNOS58
Inverse agonism of lysophospholipids with cationic head groups at Gi-coupled receptor GPR8255
GPR146 regulates pulmonary vascular remodeling by promoting pulmonary artery smooth muscle cell proliferation through 5-lipoxygenase55
Characterisation of bis(4-aminoquinoline)s as α1A adrenoceptor allosteric modulators53
Ginsenoside Rg1 promotes fetal hemoglobin production in vitro: A potential therapeutic avenue for β-thalassemia53
Effects of chronic mirabegron treatment on metabolic and cardiovascular parameters as well as on atherosclerotic lesions of WHHL rabbits with high-fructose high-fat diet-induced insulin resistance.53
The antidiabetic drug teneligliptin induces vasodilation via activation of PKG, Kv channels, and SERCA pumps in aortic smooth muscle53
Low-intensity pulsed ultrasound prevents angiotensin II-induced aortic smooth muscle cell phenotypic switch via hampering miR-17-5p and enhancing PPAR-γ53
Phosphodiesterase-1 inhibitor modulates Ca2+ regulation in sirtuin 1-deficient mouse cardiomyocytes51
IL-1 receptor-associated kinase family proteins: An overview of their role in liver disease51
Dehydrocostuslactone attenuated oxygen and glucose deprivation/reperfusion-induced PC12 cell injury through inhibition of apoptosis and autophagy by activating the PI3K/AKT/mTOR pathway51
Eukaryotic elongation factor 2 kinase inhibitor, A484954 inhibits perivascular sympathetic nerve stimulation-induced vasoconstriction in isolated renal artery50
Toward precision dosing of linezolid in critical ill patients: efficiency and risk of thrombocytopenia analysis by population PKPD modeling and simulations49
Ghrelin alleviates placental dysfunction by down-regulating NF-κB phosphorylation in LPS-induced rat model of preeclampsia48
Molecular interplay between EIF4 family and circular RNAs in cancer: Mechanisms and therapeutics48
Molecular mechanism and therapeutic significance of dihydromyricetin in nonalcoholic fatty liver disease48
The mitochondria-gut microbiota crosstalk – A novel frontier in cardiovascular diseases48
Resveratrol ameliorates cognitive impairment with improvement of gut microbiota, inflammation, neurogenesis, and synaptic proteins in a mouse model of Gulf War Illness48
Preventive effects of (−) epicatechin on tachycardia, cardiac hypertrophy, and nuclear factor- κB inflammatory signaling pathway in isoproterenol-induced myocardial infarcted rats47
Tenacissoside H repressed the progression of glioblastoma by inhibiting the PI3K/Akt/mTOR signaling pathway47
Corosolic acid attenuates platelet-derived growth factor signaling in macrophages and smooth muscle cells of pulmonary arterial hypertension47
Advancing health care via artificial intelligence: From concept to clinic47
Melittin suppresses aerobic glycolysis by regulating HSF1/PDK3 to increase chemosensitivity of NSCLC47
Suppression of hippocampal GABAergic transmission impairs memory in rodent models of Alzheimer's disease46
Risperidone impedes glutamate excitotoxicity in a valproic acid rat model of autism: Role of ADAR2 in AMPA GluA2 RNA editing46
Dopamine agonists versus levodopa monotherapy in early Parkinson's disease for the potential risks of motor complications: A network meta-analysis44
Cardiovascular protective properties of the natural product eugenol44
The novel GLP-1 / GIP dual agonist DA3-CH is more effective than liraglutide in the MPTP mouse model of Parkinson's disease43
Optimizing the structure of repurposed metformin can improve anti-cholinesterase and anti-amyloidogenic effects43
Vanin1 (VNN1) in chronic diseases: Future directions for targeted therapy43
Optimizing dose selection for doxorubicin-induced cardiotoxicity in mice: A comprehensive analysis of single and multiple-dose regimens43
Compound Z526 alleviates chemotherapy-induced cachectic muscle loss by ameliorating oxidative stress-driven protein metabolic imbalance and apoptosis42
Protein detection and localization of the non-selective cation channel TRPC6 in the human heart42
Long non-coding RNA MALAT1 modulates myocardial ischemia-reperfusion injury through the PI3K/Akt/eNOS pathway by sponging miRNA-133a-3p to target IGF1R expression42
Small molecule CGRP receptor antagonists for the preventive treatment of migraine: A review42
Inclusion of the in-chain sulfur in 3-thiaCTU increases the efficiency of mitochondrial targeting and cell killing by anticancer aryl-urea fatty acids41
Abaloparatide: A review of preclinical and clinical studies41
Significance of NMDA receptor-targeting compounds in neuropsychological disorders: An in-depth review41
Effects of oleanolic acid and ursolic acid on depression-like behaviors induced by maternal separation in mice41
Cyclin-dependent kinase 5 inhibitor attenuates lipopolysaccharide-induced neuroinflammation through metabolic reprogramming40
PI3K/mTOR dual-inhibition with VS-5584 enhances anti-leukemic efficacy of ponatinib in blasts and Ph-negative LSCs of chronic myeloid leukemia40
Novel SREBP1 inhibitor cinobufotalin suppresses proliferation of hepatocellular carcinoma by targeting lipogenesis40
RNAi in psoriasis: A melodic exploration of miRNA, shRNA, and amiRNA with a spotlight on siRNA39
Nitisinone attenuates cartilage degeneration and subchondral osteoclastogenesis in osteoarthritis and concomitantly inhibits the cGAS/STING/NF-κB pathway39
Isorhynchophylline ameliorates the progression of osteoarthritis by inhibiting the NF-κB pathway39
3,3′-O-dimethylquercetin: A bi-functional vasodilator isolated from green propolis of the Caatinga Mimosa tenuiflora39
Deciphering TGF-β1's role in drug resistance and leveraging plant bioactives for cancer therapy38
Integrating network pharmacology, transcriptomics, and molecular simulation to reveal the mechanism of tert-butylhydroquinone for treating diabetic retinopathy38
Phloretin and Enalapril co-administration ameliorates hyperglycemia mediated exacerbation of myocardial injury in rats38
Novel combinatorial autophagy inhibition therapy for triple negative breast cancers38
Amorphous selenium nanodots alleviate non-alcoholic fatty liver disease via activating VEGF receptor 1 to further inhibit phosphorylation of JNK/p38 MAPK pathways38
Astragaloside IV mitigates cerebral ischaemia-reperfusion injury via inhibition of P62/Keap1/Nrf2 pathway-mediated ferroptosis38
Small-molecule targeting PKM2 provides a molecular basis of lactylation-dependent fibroblast-like synoviocytes proliferation inhibition against rheumatoid arthritis37
Validating the temporal performance of genetic biomarkers in an animal model of recurrence/ non-recurrence myocardial infarction persuades by bioinformatics tools37
HSP90: A promising target for NSCLC treatments37
Metformin alleviates glucolipotoxicity-induced pancreatic β cell ferroptosis through regulation of the GPX4/ACSL4 axis37
Evodiamine impairs HIF1A histone lactylation to inhibit Sema3A-mediated angiogenesis and PD-L1 by inducing ferroptosis in prostate cancer36
Ginsenoside Rb1 promotes the activation of PPARα pathway via inhibiting FADD to ameliorate heart failure36
Protective effect of 5,6,7,8-Tetrahydroxyflavone on high altitude cerebral edema in rats36
Hesperetin ameliorates spinal cord injury in rats through suppressing apoptosis, oxidative stress and inflammatory response36
Nanomedicine: A great boon for cardiac regenerative medicine36
Neuroprotective effect of Perillyl alcohol in sporadic Alzheimer's disease in rats36
Dihydrotanshinone I improves cardiac function by promoting lymphangiogenesis after myocardial ischemia-reperfusion injury35
Manzamine A: A promising marine-derived cancer therapeutic for multi-targeted interactions with E2F8, SIX1, AR, GSK-3β, and V-ATPase - A systematic review35
Galangin ameliorates osteoarthritis progression by attenuating extracellular matrix degradation in chondrocytes via the activation of PRELP expression35
Editorial Board35
The key roles of non-coding RNAs in the pathophysiology of hypertension35
Protective effects of 5(S)-5-carboxystrictosidine on myocardial ischemia-reperfusion injury through activation of mitochondrial KATP channels35
Mutation of valine 53 at the interface between extracellular and transmembrane domains of the β2 principal subunit affects the GABAA receptor gating35
Editorial Board35
Cycloheptylprodigiosin from marine bacterium Spartinivicinus ruber MCCC 1K03745T induces a novel form of cell death characterized by Golgi disruption and enhanced secretion of cathepsin D in non-small35
High-throughput screening of the natural STK11 agonist dauricine: A biphenylisoquinoline alkaloid exerting anti-NSCLC effects and reversing gefitinib resistance35
Repositioning of Montelukast to inhibit proliferation of mutated KRAS pancreatic cancer through a novel mechanism that interfere the binding between KRAS and GTP/GDP34
Tumoral EIF4EBP1 regulates the crosstalk between tumor-associated macrophages and tumor cells in MRTK34
Research progress on the role of orphan receptor GPR139 in neuropsychiatric behaviours33
Sustained AT1R stimulation induces upregulation of growth factors in human cardiac fibroblasts via Gαq/TGF-β/ERK signaling that influences myocyte hypertrophy33
Inhibition of CHIT1 as a novel therapeutic approach in idiopathic pulmonary fibrosis33
Effects of intranasal azithromycin on features of cigarette smoke-induced lung inflammation33
Anti-cancer impact of Hypericin in B-CPAP cells: Extrinsic caspase dependent apoptosis induction and metastasis obstruction33
Crosstalk between endothelial cells with a non-canonical EndoMT phenotype and cardiomyocytes/fibroblasts via IGFBP5 aggravates TAC-induced cardiac dysfunction33
Teneligliptin, a DPP4 inhibitor protects dopaminergic neurons in PD models via inhibiting of oxidative stress and ferroptosis33
Poncirin ameliorates cardiac ischemia-reperfusion injury by activating PI3K/AKT/PGC-1α signaling33
Face validation and pharmacologic analysis of Sik3 mutant mouse as a possible model of idiopathic hypersomnia33
Next generation Bruton's tyrosine kinase inhibitors – characterization of in vitro potency and selectivity33
Naproxen as a potential candidate for promoting rivastigmine anti-Alzheimer activity against aluminum chloride-prompted Alzheimer's-like disease in rats; neurogenesis and apoptosis modulation as a pos32
Pirfenidone and nintedanib attenuates pulmonary artery endothelial and smooth muscle cells transformations induced by IL-1132
Involvement of ferroptosis in eribulin-induced cytotoxicity in ovarian clear cell carcinoma32
Quercetin and piperine enriched nanostructured lipid carriers (NLCs) to improve apoptosis in oral squamous cellular carcinoma (FaDu cells) with improved biodistribution profile32
Kurarinone induced p53-independent G0/G1 cell cycle arrest by degradation of K-RAS via WDR76 in human colorectal cancer cells32
Astragaloside IV protects against C/EBP homologous protein-mediated apoptosis in oxidized low-density lipoprotein-treated macrophages by promoting autophagy32
Trigeminal neuropathic pain reduces 50-kHz ultrasonic vocalizations in rats, which are restored by analgesic drugs32
Oncolytic viruses as emerging therapy against cancers including Oncovirus-induced cancers32
Effects of the serotonin 5-HT1B receptor agonist CP 94253 on the locomotor activity and body temperature of preweanling and adult male and female rats32
Alternative role of glucagon-like Peptide-1 receptor agonists in neurodegenerative diseases32
A BET inhibitor, NHWD-870, can downregulate dendritic cells maturation via the IRF7-mediated signaling pathway to ameliorate imiquimod-induced psoriasis-like murine skin inflammation32
Transcription factor EB protects against endoplasmic reticulum stress in human coronary artery endothelial cells32
Lapatinib ditosylate rescues motor deficits in rotenone-intoxicated rats: Potential repurposing of anti-cancer drug as a disease-modifying agent in Parkinson's disease32
Ginsenoside Rd attenuates myocardial ischemia injury through improving mitochondrial biogenesis via WNT5A/Ca2+ pathways32
Corrigendum to “Protective effects of cortex fraxini coumarines against oxonate-induced hyperuricemia and renal dysfunction in mice” [Eur. J. Pharmacol. 666 (2011) 196–204]31
Hepatitis B Virus X Protein promotes VWF-mediated HCC progression through ST8SIA6-AS1/miR-3150b-3p/ASCL1 axis31
Curcumin nicotinate decreases serum LDL cholesterol through LDL receptor-mediated mechanism31
Up-regulated ITGB4 promotes hepatocellular carcinoma metastasis by activating hypoxia-mediated glycolysis and cancer-associated fibroblasts31
Editorial Board31
Sophoricoside ameliorates cerebral ischemia-reperfusion injury dependent on activating AMPK31
Antidepressant-like effect of sodium orthovanadate in a mouse model of chronic unpredictable mild stress31
Sodium nitrite induces tolerance in the mouse aorta: Involvement of the renin-angiotensin system, nitric oxide synthase, and reactive oxygen species31
Recent advancements in targeting the immune system to treat hypertension31
Interferon therapy in patients with SARS, MERS, and COVID-19: A systematic review and meta-analysis of clinical studies31
Trilobatin alleviates non-alcoholic fatty liver disease in high-fat diet plus streptozotocin-induced diabetic mice by suppressing NLRP3 inflammasome activation30
Biochanin A inhibits excitotoxicity-triggered ferroptosis in hippocampal neurons30
Alpha1B-adreneroceptor is involved in norepinephrine-induced pulmonary artery smooth muscle cell proliferation via p38 signaling30
Potential of Orlistat to induce apoptotic and antiangiogenic effects as well as inhibition of fatty acid synthesis in breast cancer cells30
LncRNAS—modulators of neurovascular units in diabetic retinopathy30
Targets, trials and tribulations in Alzheimer therapeutics30
Pregabalin can interact synergistically with Kv7 channel openers to exert antinociception in mice30
Influence of adrenalectomy on the gut microbiome and MDMA-induced hyperthermia30
Succinate level is increased and succinate dehydrogenase exerts forward and reverse catalytic activities in lipopolysaccharides-stimulated cardiac tissue: The protective role of dimethyl malonate30
CRISPR/Cas9-based multiplex genome editing of BCL11A and HBG efficiently induces fetal hemoglobin expression30
Targeting endothelial cells: A novel strategy for pulmonary fibrosis treatment30
SGLT2 inhibitor dapagliflozin mitigates skeletal muscle pathology by modulating key proteins involved in glucose and ion homeostasis in an animal model of heart failure30
Cancer-associated fibroblasts (CAFs) and tumor-associated macrophages (TAMs); where do they stand in tumorigenesis and how they can change the face of cancer therapy?30
CYT997 induces apoptosis in hypertrophic scar fibroblasts and inhibits scar formation30
Advanced dressings based on novel biological targets for diabetic wound healing: A review30
Human umbilical cord-derived stem cell sheets improve left ventricular function in rat models of ischemic heart failure29
Anti-pancreatic lipase and anti-adipogenic effects of 5,7,3′,4′,5′-pentamethoxy and 6,2′,4′-trimethoxy flavone - An in vitro study29
Asiatic acid protects articular cartilage through promoting chondrogenesis and inhibiting inflammation and hypertrophy in osteoarthritis29
Dankasterone A induces prostate cancer cell death by inducing oxidative stress29
Demyelination in cuprizone mice is ameliorated by calycosin mediated through astrocyte Nrf2 signaling pathway29
Pirfenidone improves voiding function by suppressing bladder fibrosis in underactive bladder rats29
Potential role of remimazolam in alleviating bone cancer pain in mice via modulation of translocator protein in spinal astrocytes29
Effects of cannabinoid agonists and antagonists in male rats discriminating the synthetic cannabinoid AM220129
Ankrd1 regulates endogenous cardiac regeneration in mice by modulating cyclin D128
Hypoxia activates GPR146 which participates in pulmonary vascular remodeling by promoting pyroptosis of pulmonary artery endothelial cells28
Sodium houttuyfonate protects against cardiac injury by regulating cardiac energy metabolism in diabetic rats28
LRP1 at the crossroads of Parkinson's and Alzheimer's: Divergent roles in α-synuclein and amyloid pathology28
Genkwanin blocks the interaction between phosphorylated JNK and NFATc1 to promote osteogenic differentiation and collagen Ⅰ α1 production28
Inhibition of abnormally activated HIF-1α-GLUT1/3-glycolysis pathway enhances the sensitivity of hepatocellular carcinoma to 5-caffeoylquinic acid and its derivatives28
Aucubin supplementation alleviate diabetes induced-disruption of blood-testis barrier and testicular damage via stabilizing cell junction integrity28
Metabolic reprogramming of glutamine involved in tumorigenesis, multidrug resistance and tumor immunity28
Tryptanthrin impairs platelet function and thrombus formation by reducing Gp1bα expression28
Stabilization of mitochondrial function by chlorogenic acid protects against kainic acid-induced seizures and neuronal cell death in rats28
Valdecoxib blocks rat TRPV2 channels28
Ginkgolide A alleviates cardiac remodeling in mice with myocardial infarction via binding to matrix metalloproteinase-9 to attenuate inflammation28
Hypoxia-inducible factor-1: Regulatory mechanisms and drug therapy in myocardial infarction27
Dioscin alleviates lung ischemia/reperfusion injury by regulating FXR-mediated oxidative stress, apoptosis, and inflammation27
Astragalus polysaccharide attenuates bleomycin-induced pulmonary fibrosis by inhibiting TLR4/ NF-κB signaling pathway and regulating gut microbiota27
LncRNA DANCR deficiency promotes high glucose-induced endothelial to mesenchymal transition in cardiac microvascular cells via the FoxO1/DDAH1/ADMA signaling pathway27
A novel Toll-like receptor 7/8–specific antagonist E6742 ameliorates clinically relevant disease parameters in murine models of lupus27
Recent trends in diabetic wound healing with nanofibrous scaffolds27
Salidroside attenuates high altitude hypobaric hypoxia-induced brain injury in mice via inhibiting NF-κB/NLRP3 pathway27
Cancer chemotherapy resistance: Mechanisms and recent breakthrough in targeted drug delivery27
Drug repurposing: An emerging strategy in alleviating skin cancer27
Editorial Board26
Inhibiting 5-HT2C receptor in the hippocampus rescues EphB2-dependent memory impairment in mice26
Integrated network pharmacology and molecular docking analyses of the mechanisms underlying the antihypertensive effects of lotusine26
Comparative efficacy and acceptability of drug treatments for Parkinson’s disease with depression: A systematic review with network meta-analysis26
Editorial Board26
In vivo and In vitro Crosstalk Among CBD, Aβ, and endocannabinoid system enzymes and receptors26
Synthetic flavokawain analog (E)-1-(2′-hydroxy-4′,6′-dimethoxyphenyl)-3-(3-methoxy-4-(3-morpholinopropoxy)phenyl)prop-2-en-1-one (FK-morph) effectively regresses endometriotic implants in rats26
Editorial Board26
Exploring the landscape of pharmacology education in Health Professions Programs: From historical perspectives to current approaches to teaching26
Tulipalin A suppressed the pro-inflammatory polarization of M1 macrophage and mitigated the acute lung injury in mice via interference DNA binding activity of NF-κB25
Fumarate and its downstream signalling pathways in the cardiorenal system: Recent insights and novel expositions in the etiology of hypertension25
Biopharmaceuticals against substance use disorders – Present and future25
Effects of proprotein convertase subtilisin-kexin type 9 inhibitors on inflammatory and hemostatic parameters in post myocardial infarction patients25
PAI-1 siRNA-loaded biomimetic nanoparticles for ameliorating diminished ovarian reserve and inhibiting ovarian fibrosis25
Imperatorin attenuates CCl4-induced cirrhosis and portal hypertension by improving vascular remodeling and profibrogenic pathways25
Synergism of small molecules targeting VDAC with sorafenib, regorafenib or lenvatinib on hepatocarcinoma cell proliferation and survival25
Nonadditive transcriptional change analysis identifies regulators for ginsenoside Rg3 to alleviate synergistic cytokine production in TLR2/3 dual-stimulated macrophages25
GW501516 facilitated tumor immune escape by inhibiting phagocytosis25
Dose-dependent opposite effects of nortriptyline on affective-like behavior in adolescent rats: Comparison with adult rats25
Escaping a second time round: A replication and extension study on the motivational climate of and knowledge gain in a general pharmacology course25
Discovery of cinnamoyl–flavonoid hybrid derivatives as inhibitors of SARS-CoV-2 Mpro and anti-inflammatory agents: Experimental and in silico insights into their efficacy against lipopolysaccharide-in24
Cuproptosis induced by curcumin interfering with proliferation and energy metabolism in colorectal cancer: 3D tumor model and computational simulations reveal curcumin inhibition of HSPD1 and CALCOCO224
Catalyzing biopharma leaders: Sparking innovative medicines through inclusive engagement24
A positive allosteric modulator of α7 nicotinic receptor reduces levodopa-induced dyskinesias in hemi-parkinsonian mice24
lncRNA BBOX1-AS1 silencing inhibits esophageal squamous cell cancer progression by promoting ferroptosis via miR-513a-3p/SLC7A11 axis24
Brusatol modulates the Nrf2/GCLC pathway to enhance ferroptosis in the treatment of oral squamous cell carcinoma24
Beyond chemotherapy: Exploring 5-FU resistance and stemness in colorectal cancer24
Investigation of the effects of losartan and captopril on rotenone-induced inflammation via TLR4/NLRP3 pathway: An integrative in vitro and in silico study23
FGF17 protects cerebral ischemia reperfusion-induced blood-brain barrier disruption via FGF receptor 3-mediated PI3K/AKT signaling pathway23
Simultaneous nanocarrier-mediated delivery of siRNAs and chemotherapeutic agents in cancer therapy and diagnosis: Recent advances23
Targeting TRPs in autophagy regulation and human diseases23
The endocrine disruptor vinclozolin causes endothelial injury via eNOS/Nox4/IRE1α signaling23
Harringtonine metabolites: 5'-de-O-methylharringtonine and cephalotaxine, targeting spike protein and TMPRSS2 to double block membrane fusion of SARS-CoV-2 and its variants23
Mesenchymal stem cells alleviate inflammatory responses through regulation of T-cell subsets23
IGF2/IGF2R/Sting signaling as a therapeutic target in DSS-induced ulcerative colitis23
Purinergic ionotropic P2X7 and metabotropic glutamate mGlu5 receptors crosstalk influences pro-inflammatory conditions in microglia23
Michael acceptor-dependent pro-oxidative intervention against angiogenesis by [6]-dehydroshogaol, a pungent constituent of ginger23
Modulation of SIRT6 related signaling pathways of p-AKT/mTOR and NRF2/HO-1 by memantine contributes to curbing the progression of tamoxifen/HFD-induced MASH in rats23
Involvement of ObRb receptor, nitric oxide, and BKCa channel signaling pathways in leptin-induced relaxation of pregnant mouse uterus23
Corrigendum to “Combination therapy with citalopram, bupropion, and lithium for the amelioration of the depressive-related effects induced by dexamethasone in male mice” [Eur. J. Pharmacol. 1002 (202523
Novel archetype in psoriasis management bridging molecular dynamics in exploring novel therapies23
Development of a novel Poly (I:C)-induced murine model with accelerated lupus nephritis and examination of the therapeutic effects of mycophenolate mofetil and a cathepsin S inhibitor23
A novel nordihydroguaiaretic acid analog, compound 3a, alleviates acute lung injury by exerting antiapoptotic and antiinflammatory effects23
A combination of peripherally restricted CB1 and CB2 cannabinoid receptor agonists reduces bladder afferent sensitisation in cystitis23
Desmopressin enhances random-pattern skin flap survival in rats: Possible role of vasopressin Type-1a and 2 receptors23
Novel prospects in targeting neurodegenerative disorders via autophagy22
Comparison of the effects of peficitinib and tofacitinib in the adjuvant-induced arthritis rat model22
LncRNA MEG3 reverses CCl4-induced liver fibrosis by targeting NLRC522
Mendelian randomization analysis with the GEO database: Exploring the molecular mechanism underlying insulin therapy for perioperative neurocognitive disorders22
Anticancer activity and metabolic alteration in colon and prostate cancer cells by novel moxifloxacin conjugates with fatty acids22
A review of nardosinone for pharmacological activities22
The next frontier in multiple sclerosis therapies: Current advances and evolving targets22
Combination therapy with cetirizine and anti-PD-1 antibody suppresses colitis-induced colon tumor formation in mice22
Emerging therapeutic avenues in cardiac amyloidosis22
Comprehensive analysis of transcriptomics and metabolomics to illustrate the underlying mechanism of helenalin against hepatic fibrosis22
Functional studies and molecular dynamics reveal BPP-BrachyNH2-induced relaxation in male rat small mesenteric arteries via binding to argininosuccinate synthase22
Therapeutic effects of finerenone and exenatide on diabetes-induced heart failure: A combined approach targeting inflammation and oxidative stress22
The soluble guanylate cyclase (sGC) stimulator vericiguat inhibits platelet activation and thrombosis22
A peripherally restricted cannabinoid-1 receptor inverse agonist promotes insulin secretion and protects from cytokine toxicity in human pancreatic islets22
Editorial Board22
Phosphatidic acid as a cofactor of mTORC1 in platinum-based chemoresistance: Mechanisms and therapeutic potential22
Hinokitiol protects gastric injury from ethanol exposure via its iron sequestration capacity22
Evaluation of the anticancer activity of singly and doubly modified analogues of C20-epi-salinomycin22
Overexpressed mitogen-and stress-activated protein kinase 1 promotes the resistance of cytarabine in acute myeloid leukemia through brahma related gene 1-mediated upregulation of heme oxygenase-122
Oleocanthalic acid improves MASH features via a NOX1-dependent mechanism22
Molsidomine ameliorates DEXA-induced insulin resistance: Involvement of HMGB1/JAK1/STAT3 signaling pathway22
Mechanisms underlying the efficacy and limitation of dopa and tetrahydrobiopterin therapies for the deficiency of GTP cyclohydrolase 1 revealed in a novel mouse model22
Pharmacogenetics of angiotensin-converting enzyme inhibitors (ACEI) and angiotensin II receptor blockers (ARB) in cardiovascular diseases22
Establishment of a murine chronic proximal thoracic aortic aneurysm model by combining periaortic elastase application with oral BAPN administration22
Synthesis of 2-(2-(4-thioxo-3H-1,2-dithiole-5-yl) phenoxy)ethyl)isoindole-1,3-thione, a novel hydrogen sulfide-releasing phthalimide hybrid, and evaluation of its activity in models of inflammatory pa21
MitoTEMPO protects against podocyte injury by inhibiting NLRP3 inflammasome via PINK1/Parkin pathway-mediated mitophagy21
Esketamine improves cognitive function in sepsis-associated encephalopathy by inhibiting microglia-mediated neuroinflammation21
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