European Journal of Clinical Investigation

Article	Citations
Systemic immune‐inflammation index (SII) predicted clinical outcome in patients with coronary artery disease	283
Predictors of adverse prognosis in COVID‐19: A systematic review and meta‐analysis	262
Coronavirus disease 2019: The harms of exaggerated information and non‐evidence‐based measures	242
Bloodstream infections in critically ill patients with COVID‐19	191
Deciphering the COVID‐19 cytokine storm: Systematic review and meta‐analysis	166
Features of severe COVID‐19: A systematic review and meta‐analysis	132
Assessing mandatory stay‐at‐home and business closure effects on the spread of COVID‐19	128
Global perspective of COVID‐19 epidemiology for a full‐cycle pandemic	123
SARS‐CoV‐2 re‐infection risk in Austria	122
COVID‐19 and non‐alcoholic fatty liver disease: Two intersecting pandemics	92
Prognostic implications of neutrophil‐lymphocyte ratio in COVID‐19	83
Reconciling estimates of global spread and infection fatality rates of COVID‐19: An overview of systematic evaluations	81
The role of vascular smooth muscle cells in the development of aortic aneurysms and dissections	64
Estimate false‐negative RT‐PCR rates for SARS‐CoV‐2. A systematic review and meta‐analysis	62
Mitochondria, oxidative stress and nonalcoholic fatty liver disease: A complex relationship	61
Prevalence and clinical outcomes of myocarditis and pericarditis in 718,365 COVID‐19 patients	59
Risk of reinfection and disease after SARS‐CoV‐2 primary infection: Meta‐analysis	50
Clinical characteristics and prognosis of hospitalized COVID‐19 patients with incident sustained tachyarrhythmias: A multicenter observational study	47
COVID‐19 re‐infection	46
COVID‐19 Susceptibility in chronic obstructive pulmonary disease	44
The De Ritis ratio as prognostic biomarker of in‐hospital mortality in COVID‐19 patients	44
PCSK9 and atherosclerosis: Looking beyond LDL regulation	44
The end of the COVID‐19 pandemic	42
Histopathology and genetic susceptibility in COVID‐19 pneumonia	42
Clinical profile and prognosis in patients on oral anticoagulation before admission for COVID‐19	41

Platelet‐to‐lymphocyte ratio and prognosis in STEMI: A meta‐analysis	40
COVID‐19: Focus on the lungs but do not forget the gastrointestinal tract	39
High‐dose methylprednisolone in nonintubated patients with severe COVID‐19 pneumonia	39
Circ_0007142 downregulates miR‐874‐3p‐mediated GDPD5 on colorectal cancer cells	38
Diagnostic accuracy of infrared thermal imaging for detecting COVID‐19 infection in minimally symptomatic patients	33
Nonalcoholic fatty liver disease or metabolic dysfunction‐associated fatty liver disease diagnoses and cardiovascular diseases: From epidemiology to drug approaches	33
Reorganization of a large academic hospital to face COVID‐19 outbreak: The model of Parma, Emilia‐Romagna region, Italy	33
Cardiac troponin and COVID‐19 severity: Results from BIOCOVID study	33
Lactation as a programming window for metabolic syndrome	32
Paraoxonase‐2: A potential biomarker for skin cancer aggressiveness	32
MR‐proADM as marker of endotheliitis predicts COVID‐19 severity	32
Characterization of gut microbiota in polycystic ovary syndrome: Findings from a lean population	30
BNT162b2 Vaccine‐Associated Myo/Pericarditis in Adolescents: A Stratified Risk‐Benefit Analysis	30
Metabolic Disease Programming: From Mitochondria to Epigenetics, Glucocorticoid Signalling and Beyond	29
The impact of tocilizumab on anxiety and depression in patients with rheumatoid arthritis	29
Pulmonary hypertension in connective tissue diseases, new evidence and challenges	28
The role of statins in the differentiation and function of bone cells	28
Sustaining efficient immune functions with regular physical exercise in the COVID‐19 era and beyond	28
A meta‐analysis on the diagnostic performance of magnetic resonance imaging and transient elastography in nonalcoholic fatty liver disease	27
Is there an ‘ideal’ diet for patients with NAFLD?	27
Prognostic parameters of in‐hospital mortality in COVID‐19 patients—An Italian experience	27
High mortality in COVID‐19 patients with mild respiratory disease	27
COVID‐19 vaccination in children and university students	27
Adipose tissue insulin resistance and lipidome alterations as the characterizing factors of non‐alcoholic steatohepatitis	26
Multiplying effects of COVID‐19 lockdown on metabolic risk and fatty liver	26
Diagnostic accuracy of Augurix COVID‐19 IgG serology rapid test	26
Enoxaparin for thromboprophylaxis in hospitalized COVID‐19 patients: The X‐COVID‐19 Randomized Trial	26
Rheumatic heart disease anno 2020: Impacts of gender and migration on epidemiology and management	25
High rates of pulmonary artery occlusions in COVID‐19. A meta‐analysis	25
The association between serum homocysteine and depression: A systematic review and meta‐analysis of observational studies	25
Metabolic syndrome severity score and the progression of CKD	24
Comparison of pan‐immune‐inflammation value with other inflammation markers of long‐term survival afterST‐segment elevation myocardial infarction	24
Clinical conditions and echocardiographic parameters associated with mortality in COVID‐19	24
A simple echocardiographic score to rule out cardiac amyloidosis	24
Integrated care and outcomes in patients with atrial fibrillation and comorbidities	23
Exosomal circEPB41L2 serves as a sponge for miR‐21‐5p and miR‐942‐5p to suppress colorectal cancer progression by regulating the PTEN/AKT signalling pathway	23
Oxidative stress and inflammatory markers in type 2 diabetic patients	23
Effect of low‐dose colchicine in acute and chronic coronary syndromes: A systematic review and meta‐analysis	23
Association of beta‐hydroxybutyrate with development of heart failure: Sex differences in a Dutch population cohort	23
CircWHSC1 serves as an oncogene to promote hepatocellular carcinoma progression	23
Serum KL‐6 levels in pulmonary Langerhans’ cell histiocytosis	22
Characteristics of gestational diabetes subtypes classified by oral glucose tolerance test values	22
Association between diabetes mellitus and lung cancer: Meta‐analysis	22
Adaptation to SARS‐CoV‐2 under stress: Role of distorted information	22
Novel insight from the first lung transplant of a COVID‐19 patient	22
The value of high‐flow nasal cannula oxygen therapy in treating novel coronavirus pneumonia	22
The role of microbiota in nonalcoholic fatty liver disease	22
Withdrawal: “Nutrient patterns and their relationship with general and central obesity in US adults,” Mohsen Mazidi and Andre Pascal Kengne	22
Italian survey on managing immune checkpoint inhibitors in oncology during COVID‐19 outbreak	22
Dihydroorotate dehydrogenase inhibitors in SARS‐CoV‐2 infection	22

Implications of NAD+ boosters in translational medicine	21
CONVALESCENT plasma for COVID‐19: A meta‐analysis of clinical trials and real‐world evidence	21
Procedure‐related bleeding risk in patients with cirrhosis and severe thrombocytopenia	20
Direct oral anticoagulants and advanced liver disease: A systematic review and meta‐analysis	20
Colchicine use might be associated with lower mortality in COVID‐19 patients: A meta‐analysis	20
SGLT2 inhibition and COVID‐19: The road not taken	20
Higher ACE2 expression levels in epicardial cells than subcutaneous stromal cells from patients with cardiovascular disease: Diabetes and obesity as possible enhancer	20
Updating concepts on atherosclerotic inflammation: From pathophysiology to treatment	20
‘Obesities’: Position statement on a complex disease entity with multifaceted drivers	20
Frailty assessment, hip fracture and long‐term clinical outcomes in older adults	19
Nonalcoholic fatty liver disease, circulating ketone bodies and all‐cause mortality in a general population‐based cohort	19
Genetic predisposition in metabolic‐dysfunction‐associated fatty liver disease and cardiovascular outcomes—Systematic review	19
Association between asthma and cardiovascular disease	19
Estimates of COVID‐19 deaths in Mainland China after abandoning zero COVID policy	19
Non‐vitamin K vs vitamin K oral anticoagulants in patients aged > 80 year with atrial fibrillation and low body weight	19
Aprotinin treatment against SARS‐CoV‐2: A randomized phase III study to evaluate the safety and efficacy of a pan‐protease inhibitor for moderate COVID‐19	19
Interplay between gut microbiota, bone health and vascular calcification in chronic kidney disease	19
Immunopathophysiology and clinical impact of uveitis in inflammatory rheumatic diseases: An update	18
Erythrocyte membrane fluidity as a marker of diabetic retinopathy in type 1 diabetes mellitus	18
4S‐AF scheme and ABC pathway guided management improves outcomes in atrial fibrillation patients	18
Noncommunicable diseases, climate change and iniquities: What COVID‐19 has taught us about syndemic	18
The role of methylprednisolone on preventing disease progression for hospitalized patients with severe COVID‐19	18
Incidence and treatment of arrhythmias secondary to coronavirus infection in humans: A systematic review	18
Recent advances in pharmacological treatment of heart failure	17
The role of resistin and myeloperoxidase in severe sepsis and septic shock: Results from the ALBIOS trial	17
Comparison of real‐time and droplet digital PCR to detect and quantify SARS‐CoV‐2 RNA in plasma	17
Protective effect of SARS‐CoV‐2 preventive measures against ESKAPE and Escherichia coli infections	17
Circ_0000524/miR‐500a‐5p/CXCL16 axis promotes podocyte apoptosis in membranous nephropathy	17
Pattern of macrovascular invasion in hepatocellular carcinoma	17
Pre‐treatment high‐sensitivity troponin T for the short‐term prediction of cardiac outcomes in patients on immune checkpoint inhibitors	17
Volanesorsen to treat severe hypertriglyceridaemia: A pooled analysis of randomized controlled trials	17
Thirteen‐year trends in hospitalization and outcomes of patients with heart failure in Spain	17
Improving communication about COVID‐19 and emerging infectious diseases	16
Heart rate variability in patients with atrial fibrillation and hypertension	16
Selenium status and oxidative stress in obese: Influence of adiposity	16
Sex bias in admission to tertiary‐care centres for acute myocardial infarction and cardiogenic shock	16
Accuracy of prehospital point‐of‐care lactate in early in‐hospital mortality	16
Alterations in gut microbiota and elevated serum bilirubin in primary biliary cholangitis patients treated with ursodeoxycholic acid	16
The value of C‐reactive protein‐to‐albumin ratio in predicting long‐term mortality among HFrEF patients with implantable cardiac defibrillators	16
TNF‐α antagonism rescues the effect of ageing on stroke: Perspectives for targeting inflamm‐ageing	16
Racial and ethnic inequities in the early distribution of U.S. COVID‐19 testing sites and mortality	16
The NGS technology for the identification of genes associated with the ALS. A systematic review	16
Age‐ and sex‐based differences in patients with acute pericarditis	16
Influenza vaccination in cancer patients receiving immune checkpoint inhibitors: A systematic review	16
Statins: Epidrugs with effects on endothelial health?	15
CIMT as a risk factor for stroke subtype: A systematic review	15
Assessment of subclinical diabetic cardiomyopathy by speckle‐tracking imaging	15
The Iliofemoral tortuosity score predicts access and bleeding complications during transfemoral transcatheter aortic valve replacement: Data from the VIenna Cardio Thoracic aOrtic valve registrY (VICT	15
Genomic correlates of response and resistance to immune checkpoint inhibitors in carcinomas of unknown primary	15
Circ‐ACAP2 facilitates the progression of colorectal cancer through mediating miR‐143‐3p/FZD4 axis	15
Deciphering the role of epigenetic modifications in fatty liver disease: A systematic review	15
A pilot study on the impact of congenital thrombophilia in COVID‐19	15
Repurposing Colchicine to Combat Residual Cardiovascular Risk: The LoDoCo2 Trial	15
Evaluation of the chylomicron‐TG to VLDL‐TG ratio for type I hyperlipoproteinemia diagnostic	14
Telomere length, epidemiology and pathogenesis of severe COVID‐19	14
Magnesium supplementation reduces inflammation in rats with induced chronic kidney disease	14
Let‐7 mediated airway remodelling in chronic obstructive pulmonary disease via the regulation of IL‐6	14
Efficacy of various treatment modalities for nCOV‐2019: A systematic review and meta‐analysis	14
The use of comics to promote health awareness: A template using nonalcoholic fatty liver disease	14
Macrophages in the pathophysiology of NAFLD: The role of sex differences	14
MR‐ proADM to detect specific types of organ failure in infection	14
Quality of life assessment in amyloid transthyretin (ATTR) amyloidosis	14
Exercise testing in COVID‐19 era: Clinical profile, results and feasibility wearing a facemask	14
Systemic transsulfuration pathway thiol concentrations in chronic obstructive pulmonary disease patients	13
A mendelian randomization analysis: The causal association between serum uric acid and atrial fibrillation	13
High fitness levels, frequent sauna bathing and risk of pneumonia in a cohort study: Are there potential implications for COVID‐19?	13
Tracing open data in emergencies: The case of the COVID‐19 pandemic	13
BMI and atrial fibrillation recurrence post catheter ablation: A dose‐response meta‐analysis	13
CDK4/6 and PI3K inhibitors: A new promise for patients with HER2‐positive breast cancer	13
CircRUNX1 functions as an oncogene in colorectal cancer by regulating circRUNX1/miR‐485‐5p/SLC38A1 axis	13
Bariatric surgery decreases oxidative stress and protein glycosylation in patients with morbid obesity	13
Metformin and health outcomes: An umbrella review of systematic reviews with meta‐analyses	13
Sex‐specific and hormone‐related differences in vascular remodelling in atherosclerosis	13
Performance of early risk assessment tools to predict the later development of gestational diabetes	13
Social vulnerability underlying disability amongst older adults: A systematic review	13
Clinical use of controlled oxygenated rewarming of kidney grafts prior to transplantation by ex vivo machine perfusion. A pilot study	13
Global burden of gout in 1990–2019: A systematic analysis of the Global Burden of Disease study 2019	13
High‐mobility group AT‐hook 2 promotes growth and metastasis and is regulated by miR‐204‐5p in oesophageal squamous cell carcinoma	13
Neutrophil‐to‐lymphocyte and platelet‐to‐lymphocyte ratio and disease activity in rheumatoid arthritis: A systematic review and meta‐analysis	13
Serum antibody response to BNT162b2 after natural SARS‐CoV‐2 infection	13

Clinical outcomes and phylogenetic analysis in reflection with three predominant clades of SARS‐CoV‐2 variants	13
Artificial neural network‐based prediction of prolonged length of stay and need for post‐acute care in acute coronary syndrome patients undergoing percutaneous coronary intervention	13
High fitness levels attenuate the increased risk of heart failure due to low socioeconomic status: A cohort study	12
The long and winding road to target protein misfolding in cardiovascular diseases	12
Management of LDL‐cholesterol levels in patients with Diabetes Mellitus in Cardiology Practice: Real‐life evidence of Under‐treatment from the EPHESUS registry	12
Effects of hypertension on cancer survival: A meta‐analysis	12
Prognostic value of copeptin and mid‐regional proadrenomedullin in COVID‐19‐hospitalized patients	12
COVID‐19 vaccine induced myocarditis in young males: A systematic review	12
The role of metabolic syndrome in sudden cardiac death risk: Recent evidence and future directions	12
SARS‐CoV‐2 antibodies: Comparison of three high‐throughput immunoassays versus the neutralization test	12
Arterial stiffness and microvascular disease in type 2 diabetes	12
QTc evaluation in COVID‐19 patients treated with chloroquine/hydroxychloroquine	12
COVID‐19, internists and resilience: the north‐south Italy outbreak	12
Concerns related to COVID‐19 pandemic among patients with inflammatory bowel disease and its influence on patient management	12
COVID‐19 and the impact of arterial hypertension—An analysis of the international HOPE COVID‐19 Registry (Italy‐Spain‐Germany)	12
Clinical implications of vascular dysfunction in acute and convalescent COVID‐19: A systematic review	12
Relative risks and odds ratios: Simple rules on when and how to use them	12
Modulation of cellular redox environment as a novel therapeutic strategy for Parkinson's disease	11
Developmental programming and ageing of male reproductive function	11
COVID‐19 (SARS‐CoV‐2) infection and thrombotic conditions: A systematic review and meta‐analysis	11
An observational study of the Covid‐19 situation following the first pan‐European mass sports event	11
MicroRNA‐223 in gastrointestinal cancers: A systematic review and diagnostic meta‐analysis	11
Obesity, adipokines and COVID‐19	11
Clinical assessment of endothelial function in heart failure with preserved ejection fraction: A meta‐analysis with meta‐regressions	11
Re‐infection in COVID‐19: Do we exaggerate our worries?	11
A risk score for pericarditis recurrence	11
A novel way to quantify schizophrenia symptoms in clinical trials	11
Value of 3D mapping‐guided endomyocardial biopsy in cardiac sarcoidosis	11
Effects of antidiabetic drugs on psoriasis: A meta‐analysis	11
Physical activity may not be associated with long‐term risk of dementia and Alzheimer’s disease	11
Multi‐parametric system for risk stratification in mitral regurgitation: A multi‐task Gaussian prediction approach	11
Exaggerated information and COVID‐19 outbreak	11
Association between right ventricular dysfunction and adverse cardiac events in mild COPD patients	11
Vitamin D and the insulin‐like growth factor system: Implications for colorectal neoplasia	11
Identification lncRNA LOC102551149/miR‐23a‐5p pathway in hepatic fibrosis	11
Personalized recovery of severe COVID19: Rehabilitation from the perspective of patient needs	11
Does natural and hybrid immunity obviate the need for frequent vaccine boosters against SARS‐CoV‐2 in the endemic phase?	11
Cognitive impairment and endothelial dysfunction in convalescent COVID‐19 patients undergoing rehabilitation	10
Increased serum diamine oxidase activity in nonallergic patients with migraine	10
Identification of frailty and sarcopenia in hospitalised older people	10
Assessment of clinically significant portal hypertension by two‐dimensional shear wave elastography	10
Emerging cardiological issues during the COVID‐19 pandemic	10
Psychiatric disorders and Type 2 diabetes mellitus: A bidirectional Mendelian randomization	10
Non‐vitamin K antagonist oral anticoagulants versus warfarin in AF patients ≥ 85 years	10
Autoantibodies against apolipoprotein A‐1 after COVID‐19 predict symptoms persistence	10
Respiratory follow‐up after hospitalization for COVID‐19: Who and when?	10
Myeloperoxidase and CYBA genetic variants in polycystic ovary syndrome	10
Myocardial injury in patients with SARS‐CoV‐2 pneumonia: Pivotal role of inflammation in COVID‐19	10
Liver fibrosis scores and prognosis in patients with cardiovascular diseases: A systematic review and meta‐analysis	10
Gut microbiota profiles and the role of anti‐CdtB and anti‐vinculin antibodies in patients with functional gastrointestinal disorders (FGID)	10
Factors influencing oral anticoagulant use in patients newly diagnosed with atrial fibrillation	10
Association between RAC1 gene variation, redox homeostasis and type 2 diabetes mellitus	10
Stroke risk reassessment and oral anticoagulant initiation in primary care patients with atrial fibrillation: A ten‐year follow‐up	10
Investigating the capabilities of information technologies to support policymaking in COVID‐19 crisis management; a systematic review and expert opinions	10
Batch‐dependent safety of the BNT162b2 mRNA COVID‐19 vaccine	10
Effects of exercise programmes on pain, disease activity and function in ankylosing spondylitis: A meta‐analysis of randomized controlled trials	9
Circulating suPAR associates with severity and in‐hospital progression of COVID‐19	9
Basic immunology may lead to translational therapeutic rationale: SARS‐CoV‐2 and rheumatic diseases	9
What determines health professionals’ COVID‐19 vaccine hesitancy? A nationwide study	9
Compliance of atrial fibrillation treatment with the ABC pathway in patients with concomitant diabetes mellitus in the Middle East based on the Gulf SAFE registry	9
Comprehensive geriatric assessment in older adults with cancer: Recommendations by the Italian Society of Geriatrics and Gerontology (SIGG)	9
Adrenocortical dysfunction in rheumatoid arthritis: Α narrative review and future directions	9
Adipose tissue and blood leukocytes ACE2 DNA methylation in obesity and after weight loss	9
Impact of renal impairment on atrial fibrillation: ESC‐EHRA EORP‐AF Long‐Term General Registry	9
Coronary circulatory function with increasing obesity: A complex U‐turn	9
SNPs in PRKCA‐HIF1A‐GLUT1 are associated with diabetic kidney disease in a Chinese Han population with type 2 diabetes	9
Constructive and obsessive criticism in science	9
Superinfections in patients treated with Teicoplanin as anti‐SARS‐CoV‐2 agent	9
Oxidized phospholipids and lipoprotein(a): An update	9
Diabetes or endocrinopathy admitted in the COVID‐19 ward	9
IFN‐γ+ cell response and IFN‐γ release concordance after in vitro SARS‐CoV‐2 stimulation	9
Coronary microvascular disease: The “Meeting Point” of Cardiology, Rheumatology and Endocrinology	9
The role of potassium in atherosclerosis	9
Variants of candidate genes associated with the risk of obstructive sleep apnea	9
Hydrogen sulphide in liver glucose/lipid metabolism and non‐alcoholic fatty liver disease	9
Circulating pentraxin 3 in severe COVID‐19 or other pulmonary sepsis	9
Sex steroids and sex steroid‐binding globulin levels amongst middle‐aged and elderly men and women from general population	9
Prognostic role of KL‐6 in SSc‐ILD patients with pleuroparenchymal fibroelastosis	9
Limitations of the fasting proinsulin to insulin ratio as a measure of β‐cell health in people with and without impaired glucose tolerance	8
Intravascular ultrasound insights into the unstable features of the coronary atherosclerotic plaques: A systematic review and meta‐analysis	8
Course of oesophageal varices and performance of noninvasive predictors following Hepatitis C Virus clearance in compensated advanced chronic liver disease	8
Mechanical aortic valve prostheses offer a survival benefit in 50–65 year olds: AUTHEARTVISIT study	8
L‐homoarginine is associated with decreased cardiovascular‐ and all‐cause mortality	8
Hospital at Home units in the post‐COVID 19 era	8
The skin microbiome of infected pressure ulcers: A review and implications for health professionals	8
Rodent studies of developmental programming and ageing mechanisms	8
Impact of atrial fibrillation in critically ill patients admitted to a stepdown unit	8
Delayed age at menarche in chronic respiratory diseases	8
Omega‐3 phospholipids and obesity‐associated NAFLD: Potential mechanisms and therapeutic perspectives	8
Cancer in chronic heart failure patients in the GISSI‐HF trial	8
Diabetes and subclinical hypothyroidism on heart rate variability	8
Flaws and uncertainties in pandemic global excess death calculations	8
The definition of long COVID used in interventional studies	8
Protective role of Gremlin‐1 in myocardial function	8
Circ_0021087 acts as a miR‐184 sponge and represses gastric cancer progression by adsorbing miR‐184 and elevating FOSB expression	8