European Journal of Clinical Investigation

Article	Citations
Deciphering the COVID‐19 cytokine storm: Systematic review and meta‐analysis	177
Global perspective of COVID‐19 epidemiology for a full‐cycle pandemic	133
Assessing mandatory stay‐at‐home and business closure effects on the spread of COVID‐19	131
SARS‐CoV‐2 re‐infection risk in Austria	127
Prognostic implications of neutrophil‐lymphocyte ratio in COVID‐19	94
Reconciling estimates of global spread and infection fatality rates of COVID‐19: An overview of systematic evaluations	88
The role of vascular smooth muscle cells in the development of aortic aneurysms and dissections	88
Mitochondria, oxidative stress and nonalcoholic fatty liver disease: A complex relationship	73
Estimate false‐negative RT‐PCR rates for SARS‐CoV‐2. A systematic review and meta‐analysis	69
Prevalence and clinical outcomes of myocarditis and pericarditis in 718,365 COVID‐19 patients	65
Risk of reinfection and disease after SARS‐CoV‐2 primary infection: Meta‐analysis	61
PCSK9 and atherosclerosis: Looking beyond LDL regulation	51
COVID‐19 re‐infection	49
COVID‐19 Susceptibility in chronic obstructive pulmonary disease	48
Clinical characteristics and prognosis of hospitalized COVID‐19 patients with incident sustained tachyarrhythmias: A multicenter observational study	47
The De Ritis ratio as prognostic biomarker of in‐hospital mortality in COVID‐19 patients	47
The end of the COVID‐19 pandemic	46
Platelet‐to‐lymphocyte ratio and prognosis in STEMI: A meta‐analysis	43
The role of statins in the differentiation and function of bone cells	42
High‐dose methylprednisolone in nonintubated patients with severe COVID‐19 pneumonia	42
Circ_0007142 downregulates miR‐874‐3p‐mediated GDPD5 on colorectal cancer cells	42
Clinical profile and prognosis in patients on oral anticoagulation before admission for COVID‐19	41
Nonalcoholic fatty liver disease or metabolic dysfunction‐associated fatty liver disease diagnoses and cardiovascular diseases: From epidemiology to drug approaches	40
Lactation as a programming window for metabolic syndrome	39
Comparison of pan‐immune‐inflammation value with other inflammation markers of long‐term survival afterST‐segment elevation myocardial infarction	38

Cardiac troponin and COVID‐19 severity: Results from BIOCOVID study	37
MR‐proADM as marker of endotheliitis predicts COVID‐19 severity	35
BNT162b2 Vaccine‐Associated Myo/Pericarditis in Adolescents: A Stratified Risk‐Benefit Analysis	35
Characterization of gut microbiota in polycystic ovary syndrome: Findings from a lean population	34
Adipose tissue insulin resistance and lipidome alterations as the characterizing factors of non‐alcoholic steatohepatitis	34
Metabolic Disease Programming: From Mitochondria to Epigenetics, Glucocorticoid Signalling and Beyond	34
Is there an ‘ideal’ diet for patients with NAFLD?	33
Paraoxonase‐2: A potential biomarker for skin cancer aggressiveness	32
Diagnostic accuracy of infrared thermal imaging for detecting COVID‐19 infection in minimally symptomatic patients	32
The association between serum homocysteine and depression: A systematic review and meta‐analysis of observational studies	31
Pulmonary hypertension in connective tissue diseases, new evidence and challenges	31
Enoxaparin for thromboprophylaxis in hospitalized COVID‐19 patients: The X‐COVID‐19 Randomized Trial	31
COVID‐19 vaccination in children and university students	30
A meta‐analysis on the diagnostic performance of magnetic resonance imaging and transient elastography in nonalcoholic fatty liver disease	30
Prognostic parameters of in‐hospital mortality in COVID‐19 patients—An Italian experience	29
Sustaining efficient immune functions with regular physical exercise in the COVID‐19 era and beyond	28
Metabolic syndrome severity score and the progression of CKD	28
A simple echocardiographic score to rule out cardiac amyloidosis	28
Multiplying effects of COVID‐19 lockdown on metabolic risk and fatty liver	28
Clinical conditions and echocardiographic parameters associated with mortality in COVID‐19	26
CircWHSC1 serves as an oncogene to promote hepatocellular carcinoma progression	26
Exosomal circEPB41L2 serves as a sponge for miR‐21‐5p and miR‐942‐5p to suppress colorectal cancer progression by regulating the PTEN/AKT signalling pathway	26
‘Obesities’: Position statement on a complex disease entity with multifaceted drivers	26
Effect of low‐dose colchicine in acute and chronic coronary syndromes: A systematic review and meta‐analysis	26
The role of microbiota in nonalcoholic fatty liver disease	25
High rates of pulmonary artery occlusions in COVID‐19. A meta‐analysis	25
Estimates of COVID‐19 deaths in Mainland China after abandoning zero COVID policy	25
Association of beta‐hydroxybutyrate with development of heart failure: Sex differences in a Dutch population cohort	25
Characteristics of gestational diabetes subtypes classified by oral glucose tolerance test values	25
Procedure‐related bleeding risk in patients with cirrhosis and severe thrombocytopenia	24
TNF‐α antagonism rescues the effect of ageing on stroke: Perspectives for targeting inflamm‐ageing	24
Aprotinin treatment against SARS‐CoV‐2: A randomized phase III study to evaluate the safety and efficacy of a pan‐protease inhibitor for moderate COVID‐19	24
The value of high‐flow nasal cannula oxygen therapy in treating novel coronavirus pneumonia	24
Updating concepts on atherosclerotic inflammation: From pathophysiology to treatment	23
Interplay between gut microbiota, bone health and vascular calcification in chronic kidney disease	23
Frailty assessment, hip fracture and long‐term clinical outcomes in older adults	23
Direct oral anticoagulants and advanced liver disease: A systematic review and meta‐analysis	23
Integrated care and outcomes in patients with atrial fibrillation and comorbidities	23
Novel insight from the first lung transplant of a COVID‐19 patient	22
Association between asthma and cardiovascular disease	22
CONVALESCENT plasma for COVID‐19: A meta‐analysis of clinical trials and real‐world evidence	22
Nonalcoholic fatty liver disease, circulating ketone bodies and all‐cause mortality in a general population‐based cohort	22
Colchicine use might be associated with lower mortality in COVID‐19 patients: A meta‐analysis	21
Neutrophil‐to‐lymphocyte and platelet‐to‐lymphocyte ratio and disease activity in rheumatoid arthritis: A systematic review and meta‐analysis	21
Thirteen‐year trends in hospitalization and outcomes of patients with heart failure in Spain	21
The role of methylprednisolone on preventing disease progression for hospitalized patients with severe COVID‐19	21
Noncommunicable diseases, climate change and iniquities: What COVID‐19 has taught us about syndemic	21
Volanesorsen to treat severe hypertriglyceridaemia: A pooled analysis of randomized controlled trials	21
Higher ACE2 expression levels in epicardial cells than subcutaneous stromal cells from patients with cardiovascular disease: Diabetes and obesity as possible enhancer	21
4S‐AF scheme and ABC pathway guided management improves outcomes in atrial fibrillation patients	20

SGLT2 inhibition and COVID‐19: The road not taken	20
Immunopathophysiology and clinical impact of uveitis in inflammatory rheumatic diseases: An update	20
Racial and ethnic inequities in the early distribution of U.S. COVID‐19 testing sites and mortality	20
Recent advances in pharmacological treatment of heart failure	20
Circ‐ACAP2 facilitates the progression of colorectal cancer through mediating miR‐143‐3p/FZD4 axis	20
Protective effect of SARS‐CoV‐2 preventive measures against ESKAPE and Escherichia coli infections	20
Pre‐treatment high‐sensitivity troponin T for the short‐term prediction of cardiac outcomes in patients on immune checkpoint inhibitors	20
Let‐7 mediated airway remodelling in chronic obstructive pulmonary disease via the regulation of IL‐6	20
Age‐ and sex‐based differences in patients with acute pericarditis	20
Global burden of gout in 1990–2019: A systematic analysis of the Global Burden of Disease study 2019	19
Statins: Epidrugs with effects on endothelial health?	19
Sex bias in admission to tertiary‐care centres for acute myocardial infarction and cardiogenic shock	19
Alterations in gut microbiota and elevated serum bilirubin in primary biliary cholangitis patients treated with ursodeoxycholic acid	19
The role of metabolic syndrome in sudden cardiac death risk: Recent evidence and future directions	18
Incidence and treatment of arrhythmias secondary to coronavirus infection in humans: A systematic review	18
Erythrocyte membrane fluidity as a marker of diabetic retinopathy in type 1 diabetes mellitus	18
Repurposing Colchicine to Combat Residual Cardiovascular Risk: The LoDoCo2 Trial	18
Magnesium supplementation reduces inflammation in rats with induced chronic kidney disease	18
The Iliofemoral tortuosity score predicts access and bleeding complications during transfemoral transcatheter aortic valve replacement: Data from the VIenna Cardio Thoracic aOrtic valve registrY (VICT	17
The value of C‐reactive protein‐to‐albumin ratio in predicting long‐term mortality among HFrEF patients with implantable cardiac defibrillators	17
Circ_0000524/miR‐500a‐5p/CXCL16 axis promotes podocyte apoptosis in membranous nephropathy	17
CDK4/6 and PI3K inhibitors: A new promise for patients with HER2‐positive breast cancer	17
Pattern of macrovascular invasion in hepatocellular carcinoma	17
Comparison of real‐time and droplet digital PCR to detect and quantify SARS‐CoV‐2 RNA in plasma	17
High fitness levels, frequent sauna bathing and risk of pneumonia in a cohort study: Are there potential implications for COVID‐19?	16
Assessment of subclinical diabetic cardiomyopathy by speckle‐tracking imaging	16
BMI and atrial fibrillation recurrence post catheter ablation: A dose‐response meta‐analysis	16
Influenza vaccination in cancer patients receiving immune checkpoint inhibitors: A systematic review	16
A pilot study on the impact of congenital thrombophilia in COVID‐19	16
Performance of early risk assessment tools to predict the later development of gestational diabetes	16
Quality of life assessment in amyloid transthyretin (ATTR) amyloidosis	16
Does natural and hybrid immunity obviate the need for frequent vaccine boosters against SARS‐CoV‐2 in the endemic phase?	16
Batch‐dependent safety of the BNT162b2 mRNA COVID‐19 vaccine	16
Sex‐specific and hormone‐related differences in vascular remodelling in atherosclerosis	16
Selenium status and oxidative stress in obese: Influence of adiposity	16
The use of comics to promote health awareness: A template using nonalcoholic fatty liver disease	16
Prognostic value of copeptin and mid‐regional proadrenomedullin in COVID‐19‐hospitalized patients	15
Psychiatric disorders and Type 2 diabetes mellitus: A bidirectional Mendelian randomization	15
Genomic correlates of response and resistance to immune checkpoint inhibitors in carcinomas of unknown primary	15
Exercise testing in COVID‐19 era: Clinical profile, results and feasibility wearing a facemask	15
COVID‐19 vaccine induced myocarditis in young males: A systematic review	15
Efficacy of various treatment modalities for nCOV‐2019: A systematic review and meta‐analysis	15
Omega‐3 phospholipids and obesity‐associated NAFLD: Potential mechanisms and therapeutic perspectives	15
Effects of hypertension on cancer survival: A meta‐analysis	15
Deciphering the role of epigenetic modifications in fatty liver disease: A systematic review	15
Cognitive impairment and endothelial dysfunction in convalescent COVID‐19 patients undergoing rehabilitation	15
Clinical outcomes and phylogenetic analysis in reflection with three predominant clades of SARS‐CoV‐2 variants	15
Metformin and health outcomes: An umbrella review of systematic reviews with meta‐analyses	14
Assessment of clinically significant portal hypertension by two‐dimensional shear wave elastography	14
Clinical implications of vascular dysfunction in acute and convalescent COVID‐19: A systematic review	14
Telomere length, epidemiology and pathogenesis of severe COVID‐19	14
CircRUNX1 functions as an oncogene in colorectal cancer by regulating circRUNX1/miR‐485‐5p/SLC38A1 axis	14
The definition of long COVID used in interventional studies	13
Artificial neural network‐based prediction of prolonged length of stay and need for post‐acute care in acute coronary syndrome patients undergoing percutaneous coronary intervention	13
High fitness levels attenuate the increased risk of heart failure due to low socioeconomic status: A cohort study	13
Non‐vitamin K antagonist oral anticoagulants versus warfarin in AF patients ≥ 85 years	13
High‐mobility group AT‐hook 2 promotes growth and metastasis and is regulated by miR‐204‐5p in oesophageal squamous cell carcinoma	13
Flaws and uncertainties in pandemic global excess death calculations	13
Autoantibodies against apolipoprotein A‐1 after COVID‐19 predict symptoms persistence	13
Serum antibody response to BNT162b2 after natural SARS‐CoV‐2 infection	13
Clinical use of controlled oxygenated rewarming of kidney grafts prior to transplantation by ex vivo machine perfusion. A pilot study	13
Relationship between obesity severity, metabolic status and cardiovascular disease in obese adults	13
Coronary microvascular disease: The “Meeting Point” of Cardiology, Rheumatology and Endocrinology	13
The long and winding road to target protein misfolding in cardiovascular diseases	13
Risk of gonadotoxicity with immunotherapy and targeted agents remains an unsolved but crucial issue	13
Gut microbiota profiles and the role of anti‐CdtB and anti‐vinculin antibodies in patients with functional gastrointestinal disorders (FGID)	13
COVID‐19 and the impact of arterial hypertension—An analysis of the international HOPE COVID‐19 Registry (Italy‐Spain‐Germany)	13
Comprehensive geriatric assessment in older adults with cancer: Recommendations by the Italian Society of Geriatrics and Gerontology (SIGG)	13
Identification of frailty and sarcopenia in hospitalised older people	13
Clinical assessment of endothelial function in heart failure with preserved ejection fraction: A meta‐analysis with meta‐regressions	13
Re‐infection in COVID‐19: Do we exaggerate our worries?	13
Liver fibrosis scores and prognosis in patients with cardiovascular diseases: A systematic review and meta‐analysis	13
A risk score for pericarditis recurrence	13
Management of LDL‐cholesterol levels in patients with Diabetes Mellitus in Cardiology Practice: Real‐life evidence of Under‐treatment from the EPHESUS registry	13
Sex steroids and sex steroid‐binding globulin levels amongst middle‐aged and elderly men and women from general population	13
Continuous metabolic syndrome severity score and the risk ofCVDand all‐cause mortality	12
Developmental programming and ageing of male reproductive function	12
Value of 3D mapping‐guided endomyocardial biopsy in cardiac sarcoidosis	12
Prognostic role of KL‐6 in SSc‐ILD patients with pleuroparenchymal fibroelastosis	12
Association between RAC1 gene variation, redox homeostasis and type 2 diabetes mellitus	12

Investigating the capabilities of information technologies to support policymaking in COVID‐19 crisis management; a systematic review and expert opinions	12
Circulating suPAR associates with severity and in‐hospital progression of COVID‐19	12
Constructive and obsessive criticism in science	12
Molecular mechanisms of glucocorticoid resistance	12
Physical activity may not be associated with long‐term risk of dementia and Alzheimer’s disease	12
Iguratimod inhibits skin fibrosis by regulating TGF‐β1/Smad signalling pathway in systemic sclerosis	12
Modulation of cellular redox environment as a novel therapeutic strategy for Parkinson's disease	12
SARS‐CoV‐2 antibodies: Comparison of three high‐throughput immunoassays versus the neutralization test	12
MicroRNA‐223 in gastrointestinal cancers: A systematic review and diagnostic meta‐analysis	12
Mechanical aortic valve prostheses offer a survival benefit in 50–65 year olds: AUTHEARTVISIT study	12
Effects of antidiabetic drugs on psoriasis: A meta‐analysis	12
Association of lower vitamin D levels with inflammation and leucocytes parameters in patients with and without diabetes mellitus undergoing coronary angiography	12
COVID‐19 (SARS‐CoV‐2) infection and thrombotic conditions: A systematic review and meta‐analysis	11
Increased serum diamine oxidase activity in nonallergic patients with migraine	11
Future of kidney imaging: Functional magnetic resonance imaging and kidney disease progression	11
Respiratory follow‐up after hospitalization for COVID‐19: Who and when?	11
Stroke risk reassessment and oral anticoagulant initiation in primary care patients with atrial fibrillation: A ten‐year follow‐up	11
Association between right ventricular dysfunction and adverse cardiac events in mild COPD patients	11
Circulating pentraxin 3 in severe COVID‐19 or other pulmonary sepsis	11
An observational study of the Covid‐19 situation following the first pan‐European mass sports event	11
Adrenocortical dysfunction in rheumatoid arthritis: Α narrative review and future directions	11
Prognostic significance of blood urea nitrogen/creatinine ratio in chronic HFpEF	11
A novel way to quantify schizophrenia symptoms in clinical trials	11
Post COVID‐19 syndrome with impairment of flow‐mediated epicardial vasodilation and flow reserve	11
Poor self‐reported sleep is associated with risk factors for cardiovascular disease: A cross‐sectional analysis in half a million adults	11
Protective role of Gremlin‐1 in myocardial function	10
Adipose tissue and blood leukocytes ACE2 DNA methylation in obesity and after weight loss	10
The risk for chronic kidney disease in metabolically healthy obese patients: A systematic review and meta‐analysis	10
Impact of renal impairment on atrial fibrillation: ESC‐EHRA EORP‐AF Long‐Term General Registry	10
The skin microbiome of infected pressure ulcers: A review and implications for health professionals	10
Association of modifiable risk factors with ischaemic stroke subtypes in Asian versus Caucasian populations: A systematic review and meta‐analysis	10
Factors influencing oral anticoagulant use in patients newly diagnosed with atrial fibrillation	10
Liraglutide treatment attenuates inflammation markers in the cardiac, cerebral and renal microvasculature in streptozotocin‐induced diabetic rats	10
Myocardial injury in patients with SARS‐CoV‐2 pneumonia: Pivotal role of inflammation in COVID‐19	10
Endothelial dysfunction and vascular maladaptation in atrial fibrillation	10
Prognostic value of cystatin C in patients with acute coronary syndrome: A systematic review and meta‐analysis	10
Coronary circulatory function with increasing obesity: A complex U‐turn	10
Compliance of atrial fibrillation treatment with the ABC pathway in patients with concomitant diabetes mellitus in the Middle East based on the Gulf SAFE registry	10
De novo lipogenesis in non‐alcoholic fatty liver disease: Quantification with stable isotope tracers	10
Effect of intravenous pulses of methylprednisolone 250 mg versus dexamethasone 6 mg in hospitalised adults with severe COVID‐19 pneumonia: An open‐label randomised trial	10
Myeloperoxidase andCYBAgenetic variants in polycystic ovary syndrome	10
IFN‐γ+ cell response and IFN‐γ release concordance after in vitro SARS‐CoV‐2 stimulation	10
Variants of candidate genes associated with the risk of obstructive sleep apnea	10
The triglyceride‐glucose index as an adiposity marker and a predictor of fat loss induced by a low‐calorie diet	10
Oxidized phospholipids and lipoprotein(a): An update	10
The role of potassium in atherosclerosis	9
Functional dyspepsia in depression: A population‐based cohort study	9
Prevalence, clinical impact and costs of hyperkalaemia: Special focus on heart failure	9
Heart failure in patients is associated with downregulation of mitochondrial quality control genes	9
Microvascular disease increases the risk of lower limb amputation – A Western Danish cohort study	9
Serum osteopontin predicts glycaemic profile improvement in metabolic syndrome: A pilot study	9
Effectiveness of a fourth SARS‐CoV‐2 vaccine dose in previously infected individuals from Austria	9
Rodent studies of developmental programming and ageing mechanisms	9
Haemodynamic impact of MitraClip in patients with functional mitral regurgitation and pulmonary hypertension	9
Omega‐3 fatty acids in adipose tissue and risk of atrial fibrillation	9
Superinfections in patients treated with Teicoplanin as anti‐SARS‐CoV‐2 agent	9
Big data and machine learning to tackle diabetes management	9
Serum alkaline phosphatase is associated with arterial stiffness and 10‐year cardiovascular disease risk in a Chinese population	9
Unveiling the diagnostic enigma of D‐dimer testing in cancer patients: Current evidence and areas of application	9
Right ventricle dysfunction assessment for transcatheter tricuspid valve repair: A matter of debate	9
Limitations of the fasting proinsulin to insulin ratio as a measure of β‐cell health in people with and without impaired glucose tolerance	9
Clinical prediction of genotypes in hypertrophic cardiomyopathy: A systematic review	9
Hydrogen sulphide in liver glucose/lipid metabolism and non‐alcoholic fatty liver disease	9
What determines health professionals’ COVID‐19 vaccine hesitancy? A nationwide study	9
Delayed age at menarche in chronic respiratory diseases	9
Effect of PCSK9 inhibitors on remnant cholesterol and lipid residual risk: The LIPID‐REAL registry	9
Systemic immune‐inflammation index predicted the clinical outcome in patients with type‐B aortic dissection undergoing thoracic endovascular repair	9
Intravascular ultrasound insights into the unstable features of the coronary atherosclerotic plaques: A systematic review and meta‐analysis	9
Novel insights into the pathogenic impact of diabetes on the gastrointestinal tract	8
Social isolation and loneliness: Undervalued risk factors for disease states and mortality	8
Associations of toothbrushing behaviour with risks of vascular and nonvascular diseases in Chinese adults	8
Circ_0027599 elevates RUNX1 expression via sponging miR‐21‐5p on gastric cancer progression	8
Influence of placebo effect in mental disorders research: A systematic review and meta‐analysis	8
Quality of life in primary aldosteronism: A prospective observational study	8
L‐homoarginine is associated with decreased cardiovascular‐ and all‐cause mortality	8
Circ_0021087 acts as a miR‐184 sponge and represses gastric cancer progression by adsorbing miR‐184 and elevating FOSB expression	8
Εndothelial and microvascular function in CKD: Evaluation methods and associations with outcomes	8
Toothbrushing frequency and gastric and upper aerodigestive tract cancer risk: A meta‐analysis	8
An umbrella review and meta‐analysis of renin–angiotensin system drugs use and COVID‐19 outcomes	8
SARS‐CoV‐2 infection as a trigger of humoral response against apolipoprotein A‐1	8
Associations between cachexia and metalloproteinases, haemodynamics and mortality in heart failure	8
Impact of COVID‐19 lockdown on routine oncology versus emergency care at a high volume cancer centre	8
A precise review on NAATs‐based diagnostic assays for COVID‐19: A motion in fast POC molecular tests	8
Clinical utility and prognostic implications of the 4S‐AF scheme: Report from Asia Pacific Heart Rhythm Society Atrial Fibrillation Registry	8
Circulating serum and plasma levels of micro‐RNA in type‐1 diabetes in children and adolescents: A systematic review and meta‐analysis	8
Exercise restores endogenous H2S synthesis and mitochondrial function in the heart of old rats	8
Impact of malignancy on outcomes in European patients with atrial fibrillation: A report from the ESC‐EHRA EURObservational research programme in atrial fibrillation general long‐term registry	8
Hospital at Home units in the post‐COVID 19 era	8
The role of RIPK3 in liver mitochondria bioenergetics and function	8
Endothelial dysfunction and cardiovascular risk in lupus nephritis: New roles for old players?	8
Association between sleep traits and primary liver cancer: A Mendelian randomization analysis	8
Predictive model for atrial fibrillation in hypertensive diabetic patients	8
Reliable, cheap, fast and few: What is the best study for assessing medical practices? Randomized controlled trials or synthetic control arms?	7
Salivary noncoding RNA in the diagnosis of pancreatic cancer: Systematic review and meta‐analysis	7
Long‐term cardiovascular burden in prostate cancer patients receiving androgen deprivation therapy	7