European Journal of Clinical Investigation

Article	Citations
Deciphering the COVID‐19 cytokine storm: Systematic review and meta‐analysis	178
Assessing mandatory stay‐at‐home and business closure effects on the spread of COVID‐19	132
SARS‐CoV‐2 re‐infection risk in Austria	128
Reconciling estimates of global spread and infection fatality rates of COVID‐19: An overview of systematic evaluations	88
The role of vascular smooth muscle cells in the development of aortic aneurysms and dissections	88
Mitochondria, oxidative stress and nonalcoholic fatty liver disease: A complex relationship	78
Estimate false‐negative RT‐PCR rates for SARS‐CoV‐2. A systematic review and meta‐analysis	71
Prevalence and clinical outcomes of myocarditis and pericarditis in 718,365 COVID‐19 patients	66
Risk of reinfection and disease afterSARS‐CoV‐2 primary infection: Meta‐analysis	64
PCSK9 and atherosclerosis: Looking beyond LDL regulation	51
COVID‐19 re‐infection	49
The end of the COVID‐19 pandemic	47
Comparison of pan‐immune‐inflammation value with other inflammation markers of long‐term survival afterST‐segment elevation myocardial infarction	45
Circ_0007142 downregulates miR‐874‐3p‐mediated GDPD5 on colorectal cancer cells	44
The role of statins in the differentiation and function of bone cells	44
High‐dose methylprednisolone in nonintubated patients with severe COVID‐19 pneumonia	42
Clinical profile and prognosis in patients on oral anticoagulation before admission for COVID‐19	42
Nonalcoholic fatty liver disease or metabolic dysfunction‐associated fatty liver disease diagnoses and cardiovascular diseases: From epidemiology to drug approaches	41
Lactation as a programming window for metabolic syndrome	40
Cardiac troponin and COVID‐19 severity: Results from BIOCOVID study	39
Is there an ‘ideal’ diet for patients with NAFLD?	37
BNT162b2 Vaccine‐Associated Myo/Pericarditis in Adolescents: A Stratified Risk‐Benefit Analysis	36
MR‐proADM as marker of endotheliitis predicts COVID‐19 severity	35
Adipose tissue insulin resistance and lipidome alterations as the characterizing factors of non‐alcoholic steatohepatitis	34
Metabolic Disease Programming: From Mitochondria to Epigenetics, Glucocorticoid Signalling and Beyond	34

Paraoxonase‐2: A potential biomarker for skin cancer aggressiveness	32
Diagnostic accuracy of infrared thermal imaging for detecting COVID‐19 infection in minimally symptomatic patients	32
The association between serum homocysteine and depression: A systematic review and meta‐analysis of observational studies	32
COVID‐19 vaccination in children and university students	31
Enoxaparin for thromboprophylaxis in hospitalized COVID‐19 patients: The X‐COVID‐19 Randomized Trial	31
Pulmonary hypertension in connective tissue diseases, new evidence and challenges	31
A meta‐analysis on the diagnostic performance of magnetic resonance imaging and transient elastography in nonalcoholic fatty liver disease	30
A simple echocardiographic score to rule out cardiac amyloidosis	29
Prognostic parameters of in‐hospital mortality in COVID‐19 patients—An Italian experience	29
Multiplying effects of COVID‐19 lockdown on metabolic risk and fatty liver	29
Sustaining efficient immune functions with regular physical exercise in the COVID‐19 era and beyond	28
Exosomal circEPB41L2 serves as a sponge for miR‐21‐5p and miR‐942‐5p to suppress colorectal cancer progression by regulating the PTEN/AKT signalling pathway	28
Metabolic syndrome severity score and the progression of CKD	28
TNF‐α antagonism rescues the effect of ageing on stroke: Perspectives for targeting inflamm‐ageing	27
Estimates of COVID‐19 deaths in Mainland China after abandoning zero COVID policy	27
CircWHSC1 serves as an oncogene to promote hepatocellular carcinoma progression	27
‘Obesities’: Position statement on a complex disease entity with multifaceted drivers	27
Effect of low‐dose colchicine in acute and chronic coronary syndromes: A systematic review and meta‐analysis	26
Characteristics of gestational diabetes subtypes classified by oral glucose tolerance test values	26
Clinical conditions and echocardiographic parameters associated with mortality in COVID‐19	26
Association of beta‐hydroxybutyrate with development of heart failure: Sex differences in a Dutch population cohort	25
Aprotinin treatment against SARS‐CoV‐2: A randomized phase III study to evaluate the safety and efficacy of a pan‐protease inhibitor for moderate COVID‐19	25
The role of microbiota in nonalcoholic fatty liver disease	25
Integrated care and outcomes in patients with atrial fibrillation and comorbidities	24
Frailty assessment, hip fracture and long‐term clinical outcomes in older adults	24
Procedure‐related bleeding risk in patients with cirrhosis and severe thrombocytopenia	24
Updating concepts on atherosclerotic inflammation: From pathophysiology to treatment	23
Interplay between gut microbiota, bone health and vascular calcification in chronic kidney disease	23
Neutrophil‐to‐lymphocyte and platelet‐to‐lymphocyte ratio and disease activity in rheumatoid arthritis: A systematic review and meta‐analysis	22
Higher ACE2 expression levels in epicardial cells than subcutaneous stromal cells from patients with cardiovascular disease: Diabetes and obesity as possible enhancer	22
Volanesorsen to treat severe hypertriglyceridaemia: A pooled analysis of randomized controlled trials	22
Novel insight from the first lung transplant of a COVID‐19 patient	22
Nonalcoholic fatty liver disease, circulating ketone bodies and all‐cause mortality in a general population‐based cohort	22
CONVALESCENT plasma for COVID‐19: A meta‐analysis of clinical trials and real‐world evidence	22
Thirteen‐year trends in hospitalization and outcomes of patients with heart failure in Spain	21
Colchicine use might be associated with lower mortality in COVID‐19 patients: A meta‐analysis	21
Noncommunicable diseases, climate change and iniquities: What COVID‐19 has taught us about syndemic	21
Racial and ethnic inequities in the early distribution of U.S. COVID‐19 testing sites and mortality	20
Recent advances in pharmacological treatment of heart failure	20
Sex bias in admission to tertiary‐care centres for acute myocardial infarction and cardiogenic shock	20
Protective effect of SARS‐CoV‐2 preventive measures against ESKAPE and Escherichia coli infections	20
Alterations in gut microbiota and elevated serum bilirubin in primary biliary cholangitis patients treated with ursodeoxycholic acid	20
Immunopathophysiology and clinical impact of uveitis in inflammatory rheumatic diseases: An update	20
4S‐AF scheme and ABC pathway guided management improves outcomes in atrial fibrillation patients	20
Global burden of gout in 1990–2019: A systematic analysis of the Global Burden of Disease study 2019	20
Circ‐ACAP2 facilitates the progression of colorectal cancer through mediating miR‐143‐3p/FZD4 axis	20
Does natural and hybrid immunity obviate the need for frequent vaccine boosters against SARS‐CoV‐2 in the endemic phase?	19
Magnesium supplementation reduces inflammation in rats with induced chronic kidney disease	19
Erythrocyte membrane fluidity as a marker of diabetic retinopathy in type 1 diabetes mellitus	18
Incidence and treatment of arrhythmias secondary to coronavirus infection in humans: A systematic review	18

The role of metabolic syndrome in sudden cardiac death risk: Recent evidence and future directions	18
Sex‐specific and hormone‐related differences in vascular remodelling in atherosclerosis	17
Comparison of real‐time and droplet digital PCR to detect and quantify SARS‐CoV‐2 RNA in plasma	17
Pattern of macrovascular invasion in hepatocellular carcinoma	17
The value of C‐reactive protein‐to‐albumin ratio in predicting long‐term mortality among HFrEF patients with implantable cardiac defibrillators	17
CDK4/6 and PI3K inhibitors: A new promise for patients with HER2‐positive breast cancer	17
COVID‐19 vaccine induced myocarditis in young males: A systematic review	17
Selenium status and oxidative stress in obese: Influence of adiposity	17
BMI and atrial fibrillation recurrence post catheter ablation: A dose‐response meta‐analysis	17
The Iliofemoral tortuosity score predicts access and bleeding complications during transfemoral transcatheter aortic valve replacement: Data from the VIenna Cardio Thoracic aOrtic valve registrY (VICT	17
High fitness levels, frequent sauna bathing and risk of pneumonia in a cohort study: Are there potential implications for COVID‐19?	16
A pilot study on the impact of congenital thrombophilia in COVID‐19	16
The use of comics to promote health awareness: A template using nonalcoholic fatty liver disease	16
Effects of hypertension on cancer survival: A meta‐analysis	16
Performance of early risk assessment tools to predict the later development of gestational diabetes	16
Genomic correlates of response and resistance to immune checkpoint inhibitors in carcinomas of unknown primary	16
Influenza vaccination in cancer patients receiving immune checkpoint inhibitors: A systematic review	16
Batch‐dependent safety of the BNT162b2 mRNA COVID‐19 vaccine	16
Assessment of subclinical diabetic cardiomyopathy by speckle‐tracking imaging	16
Quality of life assessment in amyloid transthyretin (ATTR) amyloidosis	16
Clinical outcomes and phylogenetic analysis in reflection with three predominant clades of SARS‐CoV‐2 variants	16
Prognostic value of copeptin and mid‐regional proadrenomedullin in COVID‐19‐hospitalized patients	15
Psychiatric disorders and Type 2 diabetes mellitus: A bidirectional Mendelian randomization	15
Omega‐3 phospholipids and obesity‐associated NAFLD: Potential mechanisms and therapeutic perspectives	15
High fitness levels attenuate the increased risk of heart failure due to low socioeconomic status: A cohort study	15
Cognitive impairment and endothelial dysfunction in convalescent COVID‐19 patients undergoing rehabilitation	15
Deciphering the role of epigenetic modifications in fatty liver disease: A systematic review	15
Exercise testing in COVID‐19 era: Clinical profile, results and feasibility wearing a facemask	15
Non‐vitamin K antagonist oral anticoagulants versus warfarin in AF patients ≥ 85 years	14
Risk of gonadotoxicity with immunotherapy and targeted agents remains an unsolved but crucial issue	14
Clinical implications of vascular dysfunction in acute and convalescent COVID‐19: A systematic review	14
Relationship between obesity severity, metabolic status and cardiovascular disease in obese adults	14
Liver fibrosis scores and prognosis in patients with cardiovascular diseases: A systematic review and meta‐analysis	14
Gut microbiota profiles and the role of anti‐CdtB and anti‐vinculin antibodies in patients with functional gastrointestinal disorders (FGID)	14
CircRUNX1 functions as an oncogene in colorectal cancer by regulating circRUNX1/miR‐485‐5p/SLC38A1 axis	14
Assessment of clinically significant portal hypertension by two‐dimensional shear wave elastography	14
Metformin and health outcomes: An umbrella review of systematic reviews with meta‐analyses	14
Comprehensive geriatric assessment in older adults with cancer: Recommendations by the Italian Society of Geriatrics and Gerontology (SIGG)	14
Artificial neural network‐based prediction of prolonged length of stay and need for post‐acute care in acute coronary syndrome patients undergoing percutaneous coronary intervention	14
High‐mobility group AT‐hook 2 promotes growth and metastasis and is regulated by miR‐204‐5p in oesophageal squamous cell carcinoma	13
Management of LDL‐cholesterol levels in patients with Diabetes Mellitus in Cardiology Practice: Real‐life evidence of Under‐treatment from the EPHESUS registry	13
COVID‐19 and the impact of arterial hypertension—An analysis of the international HOPE COVID‐19 Registry (Italy‐Spain‐Germany)	13
MicroRNA‐223 in gastrointestinal cancers: A systematic review and diagnostic meta‐analysis	13
Clinical use of controlled oxygenated rewarming of kidney grafts prior to transplantation by ex vivo machine perfusion. A pilot study	13
Clinical assessment of endothelial function in heart failure with preserved ejection fraction: A meta‐analysis with meta‐regressions	13
Re‐infection in COVID‐19: Do we exaggerate our worries?	13
Circulating suPAR associates with severity and in‐hospital progression of COVID‐19	13
A risk score for pericarditis recurrence	13
The definition of long COVID used in interventional studies	13
Serum antibody response to BNT162b2 after natural SARS‐CoV‐2 infection	13
Coronary microvascular disease: The “Meeting Point” of Cardiology, Rheumatology and Endocrinology	13
The long and winding road to target protein misfolding in cardiovascular diseases	13
Flaws and uncertainties in pandemic global excess death calculations	13
Autoantibodies against apolipoprotein A‐1 after COVID‐19 predict symptoms persistence	13
Sex steroids and sex steroid‐binding globulin levels amongst middle‐aged and elderly men and women from general population	13
Identification of frailty and sarcopenia in hospitalised older people	13
Modulation of cellular redox environment as a novel therapeutic strategy for Parkinson's disease	13
Continuous metabolic syndrome severity score and the risk ofCVDand all‐cause mortality	12
Constructive and obsessive criticism in science	12
Association between RAC1 gene variation, redox homeostasis and type 2 diabetes mellitus	12
Association of lower vitamin D levels with inflammation and leucocytes parameters in patients with and without diabetes mellitus undergoing coronary angiography	12
SARS‐CoV‐2 antibodies: Comparison of three high‐throughput immunoassays versus the neutralization test	12
Value of 3D mapping‐guided endomyocardial biopsy in cardiac sarcoidosis	12
Mechanical aortic valve prostheses offer a survival benefit in 50–65 year olds: AUTHEARTVISIT study	12
Iguratimod inhibits skin fibrosis by regulating TGF‐β1/Smad signalling pathway in systemic sclerosis	12
Developmental programming and ageing of male reproductive function	12
Prognostic role of KL‐6 in SSc‐ILD patients with pleuroparenchymal fibroelastosis	12
Molecular mechanisms of glucocorticoid resistance	12
Stroke risk reassessment and oral anticoagulant initiation in primary care patients with atrial fibrillation: A ten‐year follow‐up	11
Impact of renal impairment on atrial fibrillation: ESC‐EHRA EORP‐AF Long‐Term General Registry	11
Circulating pentraxin 3 in severe COVID‐19 or other pulmonary sepsis	11
An observational study of the Covid‐19 situation following the first pan‐European mass sports event	11
Poor self‐reported sleep is associated with risk factors for cardiovascular disease: A cross‐sectional analysis in half a million adults	11
Respiratory follow‐up after hospitalization for COVID‐19: Who and when?	11
Adipose tissue and blood leukocytes ACE2 DNA methylation in obesity and after weight loss	11
The risk for chronic kidney disease in metabolically healthy obese patients: A systematic review and meta‐analysis	11
Association between right ventricular dysfunction and adverse cardiac events in mild COPD patients	11
Heart failure in patients is associated with downregulation of mitochondrial quality control genes	11
Adrenocortical dysfunction in rheumatoid arthritis: Α narrative review and future directions	11
Liraglutide treatment attenuates inflammation markers in the cardiac, cerebral and renal microvasculature in streptozotocin‐induced diabetic rats	11

Prognostic significance of blood urea nitrogen/creatinine ratio in chronic HFpEF	11
COVID‐19 (SARS‐CoV‐2) infection and thrombotic conditions: A systematic review and meta‐analysis	11
Increased serum diamine oxidase activity in nonallergic patients with migraine	11
Future of kidney imaging: Functional magnetic resonance imaging and kidney disease progression	11
Post COVID‐19 syndrome with impairment of flow‐mediated epicardial vasodilation and flow reserve	11
Myeloperoxidase andCYBAgenetic variants in polycystic ovary syndrome	10
Systemic immune‐inflammation index predicted the clinical outcome in patients with type‐B aortic dissection undergoing thoracic endovascular repair	10
IFN‐γ+ cell response and IFN‐γ release concordance after in vitro SARS‐CoV‐2 stimulation	10
Prognostic value of cystatin C in patients with acute coronary syndrome: A systematic review and meta‐analysis	10
Association of modifiable risk factors with ischaemic stroke subtypes in Asian versus Caucasian populations: A systematic review and meta‐analysis	10
Factors influencing oral anticoagulant use in patients newly diagnosed with atrial fibrillation	10
Big data and machine learning to tackle diabetes management	10
Effect of intravenous pulses of methylprednisolone 250 mg versus dexamethasone 6 mg in hospitalised adults with severe COVID‐19 pneumonia: An open‐label randomised trial	10
Endothelial dysfunction and vascular maladaptation in atrial fibrillation	10
Variants of candidate genes associated with the risk of obstructive sleep apnea	10
Coronary circulatory function with increasing obesity: A complex U‐turn	10
Oxidized phospholipids and lipoprotein(a): An update	10
Microvascular disease increases the risk of lower limb amputation – A Western Danish cohort study	10
Myocardial injury in patients with SARS‐CoV‐2 pneumonia: Pivotal role of inflammation in COVID‐19	10
Unveiling the diagnostic enigma of D‐dimer testing in cancer patients: Current evidence and areas of application	10
The skin microbiome of infected pressure ulcers: A review and implications for health professionals	10
The triglyceride‐glucose index as an adiposity marker and a predictor of fat loss induced by a low‐calorie diet	10
De novo lipogenesis in non‐alcoholic fatty liver disease: Quantification with stable isotope tracers	10
Protective role of Gremlin‐1 in myocardial function	10
Prevalence, clinical impact and costs of hyperkalaemia: Special focus on heart failure	9
Delayed age at menarche in chronic respiratory diseases	9
Serum alkaline phosphatase is associated with arterial stiffness and 10‐year cardiovascular disease risk in a Chinese population	9
Metabolic control of mitophagy	9
Effectiveness of a fourth SARS‐CoV‐2 vaccine dose in previously infected individuals from Austria	9
Limitations of the fasting proinsulin to insulin ratio as a measure of β‐cell health in people with and without impaired glucose tolerance	9
Right ventricle dysfunction assessment for transcatheter tricuspid valve repair: A matter of debate	9
Hydrogen sulphide in liver glucose/lipid metabolism and non‐alcoholic fatty liver disease	9
Influence of placebo effect in mental disorders research: A systematic review and meta‐analysis	9
L‐homoarginine is associated with decreased cardiovascular‐ and all‐cause mortality	9
Novel insights into the pathogenic impact of diabetes on the gastrointestinal tract	9
Effect of PCSK9 inhibitors on remnant cholesterol and lipid residual risk: The LIPID‐REAL registry	9
Social isolation and loneliness: Undervalued risk factors for disease states and mortality	9
The role of potassium in atherosclerosis	9
Haemodynamic impact of MitraClip in patients with functional mitral regurgitation and pulmonary hypertension	9
Omega‐3 fatty acids in adipose tissue and risk of atrial fibrillation	9
Functional dyspepsia in depression: A population‐based cohort study	9
Predictive model for atrial fibrillation in hypertensive diabetic patients	9
Toothbrushing frequency and gastric and upper aerodigestive tract cancer risk: A meta‐analysis	9
Circ_0027599 elevates RUNX1 expression via sponging miR‐21‐5p on gastric cancer progression	9
Intravascular ultrasound insights into the unstable features of the coronary atherosclerotic plaques: A systematic review and meta‐analysis	9
Rodent studies of developmental programming and ageing mechanisms	9
What determines health professionals’ COVID‐19 vaccine hesitancy? A nationwide study	9
Clinical prediction of genotypes in hypertrophic cardiomyopathy: A systematic review	9
Impact of COVID‐19 lockdown on routine oncology versus emergency care at a high volume cancer centre	8
Atrial fibrillation and Alzheimer’s disease: A conundrum	8
Endothelial dysfunction and cardiovascular risk in lupus nephritis: New roles for old players?	8
Clinical utility and prognostic implications of the 4S‐AF scheme: Report from Asia Pacific Heart Rhythm Society Atrial Fibrillation Registry	8
Vascular growth factors as potential new treatment in cardiorenal syndrome in diabetes	8
Circulating serum and plasma levels of micro‐RNA in type‐1 diabetes in children and adolescents: A systematic review and meta‐analysis	8
Associations of toothbrushing behaviour with risks of vascular and nonvascular diseases in Chinese adults	8
The role of RIPK3 in liver mitochondria bioenergetics and function	8
Dysphagia in hospitalized patients: Prevalence, related factors and impact on aspiration pneumonia and mortality	8
Association between cardiorespiratory fitness and risk of all‐cause and cause‐specific mortality	8
Association between sleep traits and primary liver cancer: A Mendelian randomization analysis	8
Εndothelial and microvascular function in CKD: Evaluation methods and associations with outcomes	8
An umbrella review and meta‐analysis of renin–angiotensin system drugs use and COVID‐19 outcomes	8
SARS‐CoV‐2 infection as a trigger of humoral response against apolipoprotein A‐1	8
Associations between cachexia and metalloproteinases, haemodynamics and mortality in heart failure	8
A precise review on NAATs‐based diagnostic assays for COVID‐19: A motion in fast POC molecular tests	8
Salivary noncoding RNA in the diagnosis of pancreatic cancer: Systematic review and meta‐analysis	8
Circ_0021087 acts as a miR‐184 sponge and represses gastric cancer progression by adsorbing miR‐184 and elevating FOSB expression	8
Immunoglobulin, nucleos(t)ide analogues and hepatitis B virus recurrence after liver transplant: A meta‐analysis	8
Exercise restores endogenous H2S synthesis and mitochondrial function in the heart of old rats	8
Impact of malignancy on outcomes in European patients with atrial fibrillation: A report from the ESC‐EHRA EURObservational research programme in atrial fibrillation general long‐term registry	8
Incidence of immune checkpoint inhibitor mediated cardiovascular toxicity: A systematic review and meta‐analysis	7
Positive airway pressure therapy in heart failure patients comorbid with obstructive sleep apnea: Cardiovascular outcomes and nighttime‐duration effect	7
Enhanced neutrophil extracellular traps formation in AF patients with dilated left atrium	7
Elevated uric acid is related to the no‐/slow‐reflow phenomenon in STEMI undergoing primary PCI	7
Effects of vegetarian versus Mediterranean diet on kidney function: Findings from the CARDIVEG study	7
The advantages of physical exercise as a preventive strategy against NAFLD in postmenopausal women	7
Changes in biomarkers of endothelial function, oxidative stress, inflammation and lipids after smoking cessation: A cohort study	7
Reliable, cheap, fast and few: What is the best study for assessing medical practices? Randomized controlled trials or synthetic control arms?	7
Pathogenic pathways and therapeutic targets of inflammation in heart diseases: A focus on Interleukin‐1	7
Glucocorticoids for acute respiratory distress syndrome: A systematic review with meta‐analysis and trial sequential analysis	7
Fatty kidney: A possible future for chronic kidney disease research	7
Human blood metabolites and risk of sepsis: A Mendelian randomization investigation	7
Fibrinogen β chain and FXIII polymorphisms affect fibrin clot properties in acute pulmonary embolism	7
Frailty trajectories in community‐dwelling older adults during COVID‐19 pandemic: The PRESTIGE study	7
Incident and recurrent myocardial infarction (MI) in relation to comorbidities: Prediction of outcomes using machine‐learning algorithms	7
Long‐term cardiovascular burden in prostate cancer patients receiving androgen deprivation therapy	7
Prognostic value of systemic immune‐inflammation index in CAD patients: Systematic review and meta‐analyses	7
Mid‐regional pro‐atrial natriuretic peptide independently predicts short‐term mortality in COVID‐19	7
Association of hydroxytyrosol enriched olive oil with vascular function in chronic coronary disease	7
Case series of massive direct oral anticoagulant ingestion—Treatment and pharmacokinetics data	7
Obesity paradox in patients with chronic total occlusion of coronary artery	7
BLS courses for refugees are feasible and induce commitment towards lay rescuer resuscitation	7
The effect of parthenolide on methamphetamine‐induced blood‐brain barrier and astrocyte alterations	7
Impact of COVID‐19 lockdown on diabetes management and follow‐up in a broad population in Spain	7
Cancer patients with venous thromboembolism: Diagnostic and prognostic value of elevated D‐dimers	7
Global longitudinal strain by CMR improves prognostic stratification in acute myocarditis presenting with normal LVEF	7