European Journal of Clinical Investigation

Article	Citations
	133
Role of PERK‐mediated pathway in the effect of mild hypothermia after cerebral ischaemia/reperfusion	86
Hydrogen sulphide: Diabetic cardiomyopathy as the paradigm of its pleiotropic function	64
Issue Information	58
rFVIII‐Fc in severe haemophilia A: The incentive switch in case of high risk of joint bleedings	52
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Adipocyte maturation impacts daunorubicin disposition and metabolism	48
Social determinants of health and cardiovascular outcomes in patients with heart failure	48
Human blood metabolites and risk of severe COVID‐19: A Mendelian randomization study	47
The use of the Crohn's disease exclusion diet (CDED) in adults with Crohn's disease: A randomized controlled trial	43
Progress and challenges in the symbiosis of AI with science and medicine	42
Clinical outcomes and phylogenetic analysis in reflection with three predominant clades of SARS‐CoV‐2 variants	39
Correction to ‘Association Between Exposure to Air Pollution and Blood Lipids in the General Population of Spain’	38
Combination therapy with an SGLT‐2 inhibitor and finerenone in DKD: Are we there yet?	38
Clinical implications of vascular dysfunction in acute and convalescent COVID‐19: A systematic review	37
Effects of glucagon‐like PEPTIDE‐1 receptor agonists on incidence of hepatocellular carcinoma and liver decompensation in patients with diabetes: A systematic review and META‐analysis	37
Effects of pharmacological inhibition of hyaluronic acid synthesis on experimental endometriosis	35
Elevated factor XIa as a modulator of plasma fibrin clot properties in coronary artery disease	35
Glucagon and glucagon‐like peptide‐1 dual agonist therapy: A possible future towards fatty kidney disease	34
ACKR3 agonism induces heterodimerization with chemokine receptor CXCR4 and attenuates platelet function	33
Practical considerations for the use of vericiguat in older patients with heart failure and reduced ejection fraction	32
Impact of sirolimus on long‐term adverse cardiovascular outcomes in kidney transplant recipients: A nationwide cohort study	31
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Impact of Anaemia on Management and Outcomes in Patients With Atrial Fibrillation: Insights From European and Asian Cohorts	30
Seasonal vitamin D levels and lupus low disease activity state in systemic lupus erythematosus	30

Does hospitalisation improve oral anticoagulant optimisation in patients with atrial fibrillation?	29
The hinge‐1 domain of Flna is not necessary for diverse physiological functions in mice	28
Blood pressure measurement for prediction of chronic pressure overload and cardiovascular events	28
Automatic reorientation algorithm for myocardial perfusion SPECT using segmentation	28
Angiopoietin‐like protein 2 and mortality in patients with heart failure—Results from an observational study	27
Short‐ and long‐term risk stratification in acutely ill medical patients by implementing ankle‐brachial index and pulse wave velocity in the emergency setting	27
Comparison between thoracic ultrasound and chest x‐ray in detection of non‐infective early complications of cardiac implantable electronic devices implantation ( CRUSADERS	27
ALKBH1 contributes to renal cell carcinoma progression by reducing N6‐methyladenine of GPR137	27
Hyperventilation testing in the diagnosis of vasospastic angina: A clinical review and meta‐analysis	26
Mental stress as a trigger of cardiovascular events: A narrative review	26
The glucagon‐like peptide‐1 receptor agonist semaglutide in diabetic kidney disease: A new kid on the block to afford maximal kidney protection	26
Incretin system and glucagon secretion in patients with chronic pancreatitis	25
A precise review on NAATs‐based diagnostic assays for COVID‐19: A motion in fast POC molecular tests	25
Prognostic significance of echocardiographic deformation imaging in adult congenital heart disease	24
Carcinoembryonic antigen‐related cell adhesion molecule 1 in cancer: Blessing or curse?	24
MyofAPPcial: Construct validity of a novel technological aid for improving clinical reasoning in the management of myofascial pain syndrome	24
Mineralocorticoid receptor antagonists in kidney transplantation	23
Cardiac proteomic profiling suggests that hypertrophic and dilated cardiomyopathy share a common pathogenetic pathway of the calcium signalling pathway	23
Refining the role of presurgical PET/4D‐CT in a large series of patients with primary hyperparathyroidism undergoing [18F]Fluorocholine PET/CT	23
Deep brain stimulation of fornix in Alzheimer's disease: From basic research to clinical practice	23
Concerns regarding interpretation in systematic review of exercise and endothelial glycocalyx	23
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The role of mean platelet volume in metabolic dysfunction associated steatotic liver disease	22
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Temporal trends of gender disparities in oral anticoagulant use in patients with atrial fibrillation	21
Constructive and obsessive criticism in science	21
The urotensin‐II receptor: A marker for staging and steroid outcome prediction in ulcerative colitis	21
Off‐label underdosing of four individual NOACs in patients with nonvalvular atrial fibrillation: A systematic review and meta‐analysis of observational studies	21
The ABCG8 polymorphism increases the risk of gallbladder cancer in the general population and gallstones in obese patients from Poland	20
The influence of hypoxia‐mediated CEACAM6 upregulation on epithelial cell and macrophage response in the context of gastric cancer	20
Elevated factor XI is associated with recurrent left ventricular thrombus of unknown origin	20
Type 2 diabetes and chronic kidney disease as long‐term predictors of cardiovascular events in patients with coronary artery disease	20
The sodium–chloride difference: A marker of prognosis in patients with acute myocardial infarction	20
Harnessing controlled human infection models to accelerate vaccine development for neglected tropical diseases: Lessons from leishmaniasis	19
The potential of artificial intelligence in clinical trials	19
Associations of 50 modifiable risk factors with atrial fibrillation using Mendelian randomization analysis	19
Cardiovascular benefits of early rhythm control and healthy lifestyle in young atrial fibrillation	19
Coronary artery calcium score and its association with stroke: A systematic review and meta‐analysis	19
Focal high‐intensity focused ultrasound therapy for localized prostate cancer: An interim analysis of the multinational FASST study	19
Age‐related differences in cardiogenic shock secondary to Takotsubo syndrome	19
No evidence linking sleep traits with white blood cell counts: Multivariable‐adjusted and Mendelian randomization analyses	19
Osteopontin is associated with neutrophil extracellular trap formation in elderly patients with severe sepsis	19
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Differential utility of various frailty diagnostic tools in non‐geriatric hospital departments of several countries: A longitudinal study	18
Percutaneous coronary revascularization versus medical therapy in chronic coronary syndromes: An updated meta‐analysis of randomized controlled trials	18
ELOVL2‐methylation and renal and cardiovascular event in patients with chronic kidney disease	18
Nutrition, cognition and chronic kidney disease: A comprehensive review of interactions and interventions	18
Role of the electrocardiogram in differentiating genetically determined dilated cardiomyopathy from athlete's heart	17
Association between the use of lipid‐lowering drugs and the risk of inflammatory bowel disease	17

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Targeting the SPHK1/S1P/S1PR2 axis ameliorates GH‐secreted pituitary adenoma progression	17
Cystatin C‐estimated GFR correlates with endothelial function improvements following bariatric surgery	17
Author index	17
Changing trends in the prevalence of heart failure impairment with Thalassemias over three decades	17
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Fatigue and itch severity in patients with PBC and PSC: Prospective analysis of two large cohorts	16
The association between the basal metabolic rate and cardiovascular disease: A two‐sample Mendelian randomization study	16
Increased epicardial nerves and decreased intramyocardial PVAT in acute myocardial infarction	16
PD‐L1 expression pattern as predictive factor of biological behaviour in intracranial meningiomas: A single‐center retrospective study	16
Impact of stroke history on procedural cerebrovascular insult probability and long‐term outcome after TAVI	16
Serum fibulin‐1 levels and target organ damage in patients at high cardiovascular risk: A prospective observational study	16
Mortality after transvenous lead extraction: A risk prediction model for sustainable care delivery	16
The effect of subcutaneous dulaglutide on weight loss in patients with Type 2 diabetes mellitus: Systematic review and meta‐analysis of randomized controlled trials	16
Nomogram for stratifying patients with lifelong premature ejaculation before using the PHQ‐9: An observational study	16
The role of artificial intelligence in cardiovascular research: Fear less and live bolder	15
Hypercholesterolemia and inflammation—Cooperative cardiovascular risk factors	15
Novel cutting edge nano‐strategies to address old long‐standing complications in cardiovascular diseases. A comprehensive review	15
Association between CMR‐derived hepatic T1‐time, tricuspid regurgitation and survival	15
Artificial‐intelligence‐based decision support tools for the differential diagnosis of colitis	15
Statin treatment reduces protein carbonylation in patients with COPD: A randomized controlled study	15
A systematic review and meta‐analysis on oncological radiotherapy in patients with a cardiac implantable electronic device: Prevalence and predictors of device malfunction in 3121 patients	15
Circulating haematopoietic stem cells and long‐term outcomes of COVID‐19	15
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Synovial expression of glucocorticoid receptor parallels fibroblast activation in patients with rheumatoid arthritis	15
Iron‐related intercellular communication in the liver: Main players and mechanisms	15
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Respiratory dysfunction in old mice could be related to inflammation and lung fibrosis induced by hyperphosphatemia	14
Psychiatric disorders and Type 2 diabetes mellitus: A bidirectional Mendelian randomization	14
Residual risk prediction in anticoagulated patients with atrial fibrillation using machine learning: A report from the GLORIA‐AF registry phase II/III	14
Artificial intelligence evaluation of coronary computed tomography angiography for coronary stenosis classification and diagnosis	14
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When less is more: The association between the expression of polymorphic CYPs and AFB1‐induced HCC	13
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Albumin, urea‐to‐albumin ratio, or the albumin‐to‐creatinine ratio to predict outcomes in heart failure with mildly reduced ejection fraction	13
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Reciprocity between the regulation of the expression and functions of CEACAM	13
Membrane oxygenator longevity was higher in argatroban‐treated patients undergoing vvECMO	13
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Sentinel lymph node biopsy for breast cancer during pregnancy: A comprehensive update	13
Liver disease in management and outcomes of European and Asian patients with atrial fibrillation: A report from two observational prospective registries	13
In‐house editorials and journalistic pieces comprise a massive corpus in the scientific literature that can be improved	13
Clinical outcomes of transcatheter edge‐to‐edge repair in patients with functional mitral regurgitation and pulmonary hypertension	12
Burden of hypertensive heart disease and its attributable risk factors in 204 countries and territories, 1990–2021: Results from the global burden of disease study 2021	12
Localization of accessory pathways in Wolff‐Parkinson‐white syndrome using ECG‐based multi‐task deep learning	12
HDL function and composition in atherothrombotic cardiovascular disease with very high HDL ‐C	12
Issue Information	12
Long‐term risk of delayed postoperative Crohn's disease recurrence in patients with no or mild endoscopic recurrence at first assessment	12
Protective effects of avasopasem manganese (GC4419) against sepsis‐induced acute lung injury: A comprehensive experimental study	12
Evidence base for yearly respiratory virus vaccines: Current status and proposed improved strategies	12
Prehospital seizures: Short‐term outcomes and risk stratification based in point‐of‐care testing	12
Impact of prior oral anticoagulation therapies on post‐discharge outcomes after COVID‐19: Results from a global federated health network analysis	12
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Prognostic impact of abnormal sodium burden in heart failure patients with preserved ejection fraction	12
Abstract	12
Advanced biomedical imaging for accurate discrimination and prognostication of mediastinal masses	12
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Anthropometric measures, predicted visceral adipose tissue and biomarkers of chronic inflammation	11
Circulation tumour DNA in predicting recurrence and prognosis in operable colorectal cancer patients: A meta‐analysis	11
Association of aortic stiffness early post myocardial infarction with left ventricular remodelling	11
Microvascular disease increases the risk of lower limb amputation – A Western Danish cohort study	11
Abnormal circulating steroids refine risk of progression to heart failure in ischemic heart disease	11
Ambulatory central BP and arterial stiffness in patients with and without intradialytic hypertension	11
Machine learning in cardiovascular risk assessment: Towards a precision medicine approach	11
Six‐minute walking distance and desaturation–distance ratio in allogeneic stem cell transplantation	11
Total lesion glycolysis is a promising predictor of chemo‐response in pancreatic cancer patients treated with neoadjuvant chemotherapy prior to surgery	11
Targeting nicotinamide N‐methyltransferase decreased aggressiveness of osteosarcoma cells	11
Preprocedural assessment of coronary artery disease in patients undergoing transcatheter aortic valve implantation: Rationale and design of the EASE‐IT CT registry	11
Sex disparities for patients with atrial fibrillation in the direct oral anticoagulant era	11
Issue Information	11
Novel 3D versus traditional transesophageal echocardiography techniques: Defining differences in the diagnosis of infective endocarditis	11
Clinical measures in chronic neuropathic pain are related to the Kennedy and endocannabinoid pathways	11
Triglyceride‐glycaemic index: Insights into predicting fetal macrosomia and its interaction with gestational diabetes mellitus: A cohort study of Chinese pregnant women	11
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Risk prediction of atrial fibrillation and its complications in the community using hs troponin I	11
56th Annual Scientific Meeting, 8–10 June 2022, Bari, Italy, “Promoting Biomedical Research, Equal Health and Environment in the post‐COVID Syndemic Era”	11
Gender differences on healthcare accessibility and outcomes of a electronic inter‐clinician consultation program at the cardiology department in a Galician Health Area	11
The autonomic nervous system and bone health in chronic kidney disease	10

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Body composition markers are more strongly associated with type 2 diabetes than inflammatory markers—Results from the study of health in Pomerania	10
Implications of inflammation and sex in lower extremity arterial disease	10
Extracellular matrix mechanical cues (dys)regulate metabolic redox homeostasis due to impaired autophagic flux	10
Adipose tissue metabolomics identifies disease stage and tumour invasiveness of rectal cancer	10
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One‐hour post‐load glucose and subclinical left atrial myocardial dysfunction in hypertensive patients	10
Ramadan intermittent fasting reduces visceral fat and improves gastrointestinal motility	10
Antihypertensive treatment changes and related clinical outcomes in older hospitalized patients	10
Sotatercept in pulmonary hypertension and beyond	10
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Deep learning for electrocardiogram interpretation: Bench to bedside	10
Promising biomarker panel to monitor therapeutic efficacy of neoadjuvant chemotherapy in pancreatic cancer patients	10
Decompressive surgery in cerebral venous thrombosis: A systematic review and meta‐analysis	10
Increased body mass index is associated with sarcopenia and related outcomes	10
The definition of long COVID used in interventional studies	9
Meta‐analysis of factors associated with antidiabetic drug prescribing for type 2 diabetes mellitus	9
Issue Information	9
The influence of viral protein R amino acid substitutions on clinical outcomes in people living with HIV: A systematic review	9
Assessing cardiorespiratory fitness relative to sex improves surgical risk stratification	9
Recent advances in multimodality imaging‐guided therapy in pericarditis	9
Low triiodothyronine syndrome is associated with stroke‐associated pneumonia	9
Heart failure in patients is associated with downregulation of mitochondrial quality control genes	9
ESCI Newsletter	9
Effects of NAD+ precursors on blood pressure, C‐reactive protein concentration and carotid intima‐media thickness: A meta‐analysis of randomized controlled trials	9
Patient‐reported outcomes in internal medicine: Methodological considerations for valid measurement and interpretation	9
First‐line diagnostic tests to intercept primary heart involvement in systemic sclerosis: Clinical associations from the SPRING‐SIR registry	9
Depression in nonalcoholic fatty liver disease and all‐cause/cause‐specific mortality	9
Risk of cardiovascular disease in elderly subjects with obesity and liver fibrosis and the potential benefit of statin treatment	9
Global, regional and national burden of epilepsy in children and adolescents, 1990–2021: A systematic analysis for the Global Burden of Disease Study 2021	9
Impact of oncologic diseases on outcome in patients with severe isolated tricuspid regurgitation	9
LINC02605 involved in paediatric Mycoplasma pneumoniae pneumonia complicated with diarrhoea via miR‐539‐5p/CXCL1 axis	9
Common misconceptions of randomized controlled trials in oncology	9
Cancer and cardiovascular diseases: A deadly combination	9
The biology of lipoprotein(a): From genetics to molecular mechanisms	9
Global, regional and national burden of alopecia areata and its associated diseases, 1990–2019: A systematic analysis of the Global Burden of Disease Study 2019	9
A Mendelian randomization study on causal effects of leisure sedentary behaviour on the risk of rheumatoid arthritis	8
Fatal attractions that trigger inflammation and drive atherosclerotic disease	8
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Sexual dimorphism in exercise‐induced response on steroid hormones to a 24‐week supervised concurrent training intervention	8
Liraglutide modulates morpho‐functional and inflammatory gastrointestinal responses in rats	8
Machine learning prediction of moderate‐to‐severe acute kidney injury after ICU admission and cardiac surgery with urine trace elements	8
Serological markers and long COVID—A rapid systematic review	8
Current investigation of carcinoembryonic antigen cell adhesion molecule (CEACAM) biology summary of the 32nd CEA symposium: 20–23 September 2024. Würzburg, Germany	8
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A weekly 4‐methylpyrazole treatment attenuates the development of non‐obese metabolic dysfunction‐associated steatotic liver disease (MASLD) in male mice: Role of JNK	8
Corrigendum	8
Frailty trajectories in community‐dwelling older adults during COVID‐19 pandemic: The PRESTIGE study	8
Sex‐associated differences in cardiac ageing: Clinical aspects and molecular mechanisms	8
The conservativeness of standard C statistics in the prediction of clinical events	8
Plasma lipoprotein(a) is associated with calcification activity of the thoracic aorta and aortic valve in statin naïve individuals with diabetes mellitus	8
Genetic evidence for the causal linkage between telomere length and aortic aneurysm risk: A Mendelian randomisation study	8
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Angiotensin converting enzyme 2 level and its significance in COVID‐19 and other diseases patients	8
Familial hypercholesterolemia is related to cardiovascular disease, heart failure and atrial fibrillation. Results from a population‐based study	8
Erythrocyte membrane fluidity: A novel biomarker of residual cardiovascular risk in type 2 diabetes	7
Sex‐specific and hormone‐related differences in vascular remodelling in atherosclerosis	7
Interatrial block, atrial fibrillation, and thrombotic events in COVID‐19	7
Educational level, clinical outcomes and quality of care in a Swiss cohort of patients with acute coronary syndromes	7
Transsulfuration and folate pathways in rheumatoid arthritis: A systematic review and meta‐analysis	7
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miR‐619‐5p and cardiogenic shock in patients with ST‐segment elevation myocardial infarction	7
Enhanced neutrophil extracellular traps formation in AF patients with dilated left atrium	7
Self‐reported sleep characteristics and cardiovascular disease risk factors	7
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Methodological and statistical considerations: Batch‐dependent adverse effects of COVID‐19 vaccines	7
Circulating suPAR associates with severity and in‐hospital progression of COVID‐19	7
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‘Obesities’: Position statement on a complex disease entity with multifaceted drivers	7
Central role of pro‐IGFII(68–88) (big IGFII) in the pathogenesis nonislet cell tumour‐induced hypoglycaemia	7
Proprotein convertase subtilisin/kexin type 9 (PCSK9) and clinical outcomes in patients with end‐stage renal disease	7
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Cardiac and renal outcomes of direct oral anticoagulants in patients with atrial fibrillation	7
Comparison of high‐sensitive cardiac troponin T and I in patients with chronic coronary syndrome	7
The body mass index increases the genetic risk scores' ability to predict risk of hepatic damage in European adolescents: The HELENA study	7
Zinc finger proteins and ATP‐binding cassette transporter‐dependent multidrug resistance	7
Tocilizumab‐related hypertriglyceridemia is independent of key molecules regulating lipid metabolism	6
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Modified Rapid Emergency Medicine Score‐Lactate (mREMS‐L) performance to screen non‐anticipated 30‐day‐related‐mortality in emergency department	6
Metabolomic profiles in serum and urine uncover novel biomarkers in children with nephrotic syndrome	6
Hot topics for the European Journal of Clinical Investigation in 2023	6
Omega‐3 fatty acids and endothelial function: A GRADE‐assessed systematic review and meta‐analysis	6
Imaging predictors of adverse prognosis in Fabry disease cardiomyopathy: A systematic review and meta‐analysis	6
Unveiling the diagnostic enigma of D‐dimer testing in cancer patients: Current evidence and areas of application	6
Exploring heart rate variability as a biomarker for frailty: A narrative review	6
Salt versus no salt restriction in heart failure a review	6
Lifestyle changes and kidney function: A 10‐year follow‐up study in patients with manifest cardiovascular disease	6
Re: ‘Effectiveness of a fourth SARS‐CoV‐2 vaccine dose in previously infected individuals’	6
Association between lactate/albumin ratio and prognosis in patients with acute myocardial infarction	6
Branched‐chain amino acids and all‐cause mortality in patients with liver cirrhosis, and the onset of diabetes in liver transplant recipients	6