Epilepsia

Article	Citations
	659
	658
PAC‐FOS: A novel translational concordance framework identifies preclinical seizure models with highest predictive validity for clinical focal onset seizures	333
Thank you to our Reviewers	252
Excitatory–inhibitory mismatch shapes node recruitment in an epileptic network	207
The transcriptomic signature of DEPDC5 KO induced mTOR hyperactivation in human neurons and its response to rapamycin treatment	201
Clinical effectiveness, feasibility, acceptability, and usability of mobile health applications for epilepsy: A systematic review	174
Hippocampal sclerosis and temporal lobe epilepsy following febrile status epilepticus: The FEBSTAT study	157
Screening for depression in patients with epilepsy: What are the benefits for physicians and patients in the real‐life setting	124
Protective effect of CACNA1A deficiency in oligogenic refractory epilepsy with CACNA1A‐CELSR2 digenic mutations	123
Surgical outcomes and motor function in pediatric peri‐Rolandic epilepsy: A single center's experience with 152 cases	118
Optimizing external validation of deep neural networks for interictal discharge detection	106
SCN8A self‐limited infantile epilepsy: Does epilepsy resolve?	100
Sleep, oscillations, and epilepsy	99
Cytomegalic parvalbumin neurons in fetal cases of hemimegalencephaly	98
Comment on: Failure to use new breakthrough treatments for epilepsy	97
Role of cholesterol in modulating brain hyperexcitability	97
Optimizing pediatric status epilepticus management: The role of early midazolam infusion and adherence to clinical practice guidelines	95
Reasons for ineligibility for clinical trials of patients with medication‐resistant epilepsy	87
Decision‐making in stereotactic epilepsy surgery	84
Long‐term neuroplasticity in language networks after anterior temporal lobe resection	81
Forty‐hertz sensory entrainment impedes kindling epileptogenesis and reduces amyloid pathology in an Alzheimer disease mouse model	78
Unmasking the role of the occipital lobe in epilepsy with eyelid myoclonia	77
Neurocardiac pathologies associated with potassium channelopathies	77
Response to Singh et al. 2023: It is premature for a unified hypothesis of sudden unexpected death in epilepsy: A great amount of research is still needed to understand the multisystem cascade	67

Topiramate ban in women of childbearing potential with idiopathic generalized epilepsy: Does effectiveness offset the teratogenic risks?	65
Statistical learning in epilepsy: Behavioral and anatomical mechanisms in the human brain	65
Impact of epilepsy on people experiencing homelessness: A mixed‐methods study	64
Evaluating the efficacy of prototype antiseizure drugs using a preclinical pharmacokinetic approach	64
Extended follow‐up after anterior temporal lobectomy demonstrates seizure recurrence 20+ years postsurgery	62
Sustained seizure freedom with adjunctive brivaracetam in patients with focal onset seizures	62
Prediction of long‐term unprovoked seizures after status epilepticus	61
Anticonvulsive properties of soticlestat, a novel cholesterol 24‐hydroxylase inhibitor	58
Scalp high‐frequency oscillation spatial distribution is consistent over consecutive nights, while rates vary with antiseizure medication changes	57
Olig2‐specific loss‐of‐function Slc35a2 results in hypomyelination and spontaneous seizures	53
Targeting interictal low‐entropy zones during epilepsy surgery predicts successful outcomes in pediatric drug‐resistant epilepsy	52
Seizure outcomes in persons with autism spectrum disorder undergoing epilepsy surgery: A systematic review and meta‐analysis	49
Delayed excitability recovery and downregulation of neurodevelopmental pathways contribute to phenotypic differences in KCNQ2‐related disorders	49
Intracerebroventricular administration for delivery of antiseizure therapeutics: Challenges and opportunities	48
Epilepsia – January 2023 – Announcements	48
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Seizure clusters: Practical aspects and clinical strategies to care for patients in the community	46
The nuances of immunotherapy for NORSE/FIRES	45
Identification of a mosaic MTOR variant in purified neuronal DNA in a patient with focal cortical dysplasia using a novel depth electrode harvesting technique	44
Development of a preclinical testing platform for clinically relevant therapy for Dravet syndrome	44
No association between histopathology and neurophysiology in surgical specimens from pediatric focal epilepsy patients	44
Quantifying hubness to predict surgical outcomes in epilepsy: Assessing resection‐hub alignment in interictal intracranial EEG networks	43
Asymmetry of generalized discharges in idiopathic generalized epilepsy in adults	43
Cerebral vascular and blood brain–barrier abnormalities in a mouse model of epilepsy and tuberous sclerosis complex	43
Decreased uncinate fasciculus integrity in functional seizures following traumatic brain injury	42
Predictive power of phase 1 studies for the identification of seizure onset zone in phase 2 in a pediatric epilepsy cohort	42
Issue Information	41
Verbal fluency functional magnetic resonance imaging detects anti‐seizure effects and affective side effects of perampanel in people with focal epilepsy	41
It is premature for a unified hypothesis of sudden unexpected death in epilepsy: A great amount of research is still needed to understand the multisystem cascade	40
Effect of levetiracetam on the gene expression of placental transporters in a murine model	40
Phase 1 study of ABI‐009 (nab‐rapamycin) for surgically refractory epilepsy (RaSuRE)	38
Analysis of practical judgment in older adults with epilepsy: An exploratory, multicenter cohort study	37
Multicenter, cross‐sectional study of the costs of illness and cost‐driving factors in adult patients with epilepsy	37
Adherence patterns in antiseizure medications influencing risk of sudden unexplained death in epilepsy: A data linkage study using dispensed prescriptions	37
Feasibility of and patient satisfaction with Readiness Brain Operation Optimization Training, a manualized cognitive prehabilitation program for epilepsy surgery	36
MEG abnormalities and mechanisms of surgical failure in neocortical epilepsy	36
Seizure freedom after surgical resection of diffusion‐weighted magnetic resonance imaging abnormalities	36
Paroxysmal slow wave events as a diagnostic biomarker for epilepsy: Lessons from rural Zambia	36
A randomized phase 2b efficacy study in patients with seizure episodes with a predictable pattern using Staccato® alprazolam for rapid seizure termination	36
Altered amygdala volumes and microstructure in focal epilepsy patients with tonic–clonic seizures, ictal, and post‐convulsive central apnea	35
Scoping review and expert‐based consensus recommendations for assessment and management of psychogenic non‐epileptic (functional) seizures (PNES) in children: A report from the Pediatric Ps	35
Association of baseline sleep duration and sleep quality with seizure recurrence in newly treated patients with epilepsy	35
Assisted reproduction and the fetal malformation risk associated with antiseizure medication exposure in pregnancy	35
Clinical adult outcome 11–30 years after pediatric epilepsy surgery: Complications and other surgical adverse events, seizure control, and cure of epilepsy	34
Statistical characteristics of large‐scale objective tonic–clonic seizure records from medical smartwatches used in daily life	34
Machine learning approaches for imaging‐based prognostication of the outcome of surgery for mesial temporal lobe epilepsy	34
Genome‐wide decrease in DNA methylation in adults with epilepsy treated with modified ketogenic diet: A prospective study	33
Health‐related quality of life in adults with drug‐resistant focal epilepsy treated with modified Atkins diet in a randomized clinical trial	33
High‐dose folic acid use and cancer risk in women who have given birth: A register‐based cohort study	33
Diet composition and sterilization modifies intestinal microbiome diversity and burden of Theiler's virus infection–induced acute seizures	33

Pharmacokinetic variability and use of therapeutic drug monitoring of cannabidiol in patients with refractory epilepsy	33
Perampanel as precision therapy in rare genetic epilepsies	32
Cognitive phenotypes in frontal lobe epilepsy	32
Flexible realistic simulation of seizure occurrence recapitulating statistical properties of seizure diaries	32
Altered thalamic connectivity patterns in pediatric temporal lobe epilepsy: A gradient mapping study	32
Epilepsy phenotype and its reproducibility after lateral fluid percussion‐induced traumatic brain injury in rats: Multicenter EpiBioS4Rx study project 1	31
Home recording of 3‐Hz spike–wave discharges in adults with absence epilepsy using the wearable Sensor Dot	31
Issue Information	31
Increasing challenges to trial recruitment and conduct over time	30
On‐scalp magnetoencephalography based on optically pumped magnetometers to investigate temporal lobe epilepsy	30
Antiseizure medication and perceived “fair” cost allocation: A factorial survey among neurologists, persons with epilepsy, their relatives, and a control group	30
Long‐term individual retention with cenobamate in adults with focal seizures: Pooled data from the clinical development program	30
Reply to: Optimizing external validation of deep neural networks for interictal discharge detection	30
Mutations associated with epileptic encephalopathy modify EAAT2 anion channel function	30
Author Index	29
Fully automated detection of focal cortical dysplasia: Comparison of MPRAGE and MP2RAGE sequences	29
Excess health care use is significantly and persistently reduced following diagnosis of late‐onset epilepsy	29
Epilepsy expands the phenotype of L‐arginine:glycine amidinotransferase deficiency	29
Splicing variants in DEPDC5‐related epilepsies: From functional characterization to correction	29
Evaluation of limbic microstructural abnormalities in temporal lobe epilepsy: A neurite orientation distribution and density imaging study	29
Issue Information	29
Reliability and diagnostic accuracy of home video recording in differentiating sleep‐related hypermotor epilepsy from disorders of arousal	29
Seizure characteristics and outcomes in patients with neurological conditions related to high‐risk paraneoplastic antibodies	29
Can biomarkers of the epileptogenic zone be characterized in patients rendered seizure‐free alone?	29
Corrigendum	29
Potassium–chloride cotransporter 2 activity dampens induced ictal‐like activity in neocortical slices containing the seizure propagation zone of temporal lobe epilepsy patients	29
Heterozygous GABAA receptor β3 subunit N110D knock‐in mice have epileptic spasms	28
Quantitative EEG biomarkers for STXBP1‐related disorders	28
Using magnetic resonance fingerprinting to characterize periventricular nodular heterotopias in pharmacoresistant epilepsy	28
Issue Information	28
Modification of brain conductivity in human focal epilepsy: A model‐based estimation from stereoelectroencephalography	27
Surfaced‐based detection of focal cortical dysplasia using magnetic resonance fingerprinting and machine learning	27
An interview with Margherita Contento, 2022 Epilepsia Prize winner for clinical research	27
Can the large language model ChatGPT‐4omni predict outcomes in adult patients with status epilepticus?	27
Racial/ethnic differences in the association of incident stroke with late onset epilepsy: The Northern Manhattan Study	27
Long‐read sequencing of recurrent FGF12 duplications in epilepsy: Insights into structural mechanisms and aberrant isoforms	27
Correction to “Health care utilization of Hispanic/Latino veterans with epilepsy: A national population‐based study”	26
Cenobamate efficacy in specific populations	26
Extracting epilepsy‐related information from unstructured clinic letters using large language models	26
Differential outcomes in familial and sporadic SCN8A self‐limited infantile epilepsies: Insights from a large international registry	26
Outcomes of the second withdrawal of anti‐seizure medication in patients with pediatric‐onset epilepsy	25
Primidone improves symptoms in TRPM3‐linked developmental and epileptic encephalopathy with spike‐and‐wave activation in sleep	25
Combined electrophysiological and morphological phenotypes in patients with genetic generalized epilepsy and their healthy siblings	25
Leveraging expertise and optimizing clinical research: Initial success of a pediatric epilepsy surgery collaborative	25
Zebrafish models of developmental epileptic encephalopathy accurately reflect clinical electrographic biomarkers	25
Efficacy and safety of perampanel in patients with seizures associated with Lennox–Gastaut syndrome: A randomized trial	25
Prognostic scores in status epilepticus: A systematic review and meta‐analysis	25
Reproduction and genetic causal attribution of epilepsy	24
Patients carrying pathogenic SCN8A variants with loss‐ and gain‐of‐function effects can be classified into five subgroups exhibiting varying developmental and epileptic components of	24
Metabolomic changes in adults with status epilepticus: A human case–control study	24
Risk of vigabatrin‐associated brain abnormalities on MRI: A retrospective and controlled study	24
Rapid eye movement sleep affects interictal epileptic activity differently in mesiotemporal and neocortical areas	24
Spike patterns surrounding sleep and seizures localize the seizure‐onset zone in focal epilepsy	24
Efficacy of cannabidiol in convulsive and nonconvulsive seizure types associated with treatment‐resistant epilepsies in the Expanded Access Program	24
High‐mobility group box 1 as a predictive biomarker for drug‐resistant epilepsy: A proof‐of‐concept study	24
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Emerging translocator protein–positron emission tomographic imaging improves detection of focal cortical dysplasia	24
Climate change: Attitudes and concerns of, and learnings from, people with neurological conditions, carers, and health care professionals	23
Epilepsia—October 2023—Announcements	23
Correction to “patterns of subregional cerebellar atrophy across epilepsy syndromes: An ENIGMA—Epilepsy study”	23
Seizure monitoring by combined diary and wearable data: A multicenter, longitudinal, observational study	23
Epilepsia – January 2025 Announcements	23
The need for an individualized approach to what is considered a clinically significant reduction in seizure frequency: A patient's perspective	23
Paroxysmal fast activity is a biomarker of treatment response in deep brain stimulation for Lennox–Gastaut syndrome	23
Seizure activity triggers tau hyperphosphorylation and amyloidogenic pathways	23
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Attenuation of initial pilocarpine‐induced electrographic seizures by methionine sulfoximine pretreatment tightly correlates with the reduction of extracellular taurine in the hippocampus	22
Predicting posttraumatic epilepsy using admission electroencephalography after severe traumatic brain injury	22
Farewell from the Editor‐in‐Chief	22
Creating rare epilepsy cohorts using keyword search in electronic health records	22
Issue Information	22
Fluoxetine accelerates epileptogenesis and magnifies disease severity in a rat model of acquired epilepsy	22
Latent class analysis of eHealth behaviors among adults with epilepsy	22
The “make or break” impact of family dynamics on psychological outcomes in focal epilepsy	22
Early life seizures and epileptic spasms in STXBP1‐related disorders	22
Efficacy of neuromodulation of the pulvinar nucleus for drug‐resistant epilepsy	21
Clioquinol as a new therapy in epilepsy: From preclinical evidence to a proof‐of‐concept clinical study	21
Response: Drug resistance in epilepsy: A reappraisal of the definition is needed	21
Increased uptake of the P2X7 receptor radiotracer 18F‐JNJ‐64413739 in the brain and peripheral organs according to the severity of status epilepticus in male mice	21
Value of ultra‐high‐field MRI in patients with drug‐resistant focal epilepsy and negative 3T MRI (EpiUltraStudy): Diagnostic gain of 7T structural analysis	21

Mesial‐to‐lateral gradients of epileptiform activity to localize mesial temporal lobe epilepsy	21
Comparison of children and adults undergoing subdural grid electrode implantation or stereoelectroencephalography in a refractory epilepsy cohort from four European centers	20
Response: “What is the risk of unprovoked seizures after acute symptomatic status epilepticus?”	20
Amitriptyline use in individuals with KCNQ2/3 gain‐of‐function variants: A retrospective cohort study	20
Haploinsufficiency of brain‐specific kinase BRSK1 causes epilepsy and neurodevelopmental disorders	20
Incidence and risk factors of posttraumatic epilepsy following pediatric traumatic brain injury: A systematic review and meta‐analysis	20
Early alterations of the neuronal network processing whisker‐related sensory signal during absence epileptogenesis	20
Sustained rescue of seizure control in patients with highly refractory chronic epilepsy using empiric immunotherapy	20
Early seizure freedom with [18F]fluorodopa positron emission tomography response after isocitrate dehydrogenase inhibition with vorasidenib: First case report	20
Peak width of skeletonized mean diffusivity as a marker of small vessel disease in patients with temporal lobe epilepsy with hippocampal sclerosis	20
Tracing topics and trends in drug‐resistant epilepsy research using a natural language processing–based topic modeling approach	20
Learning to generalize seizure forecasts	20
Role of vitamin D supplementation and vitamin D receptor in drug‐resistant epilepsy: A double‐blind placebo‐controlled trial conducted in India	20
Long‐term treatment with ganaxolone for seizures associated with cyclin‐dependent kinase‐like 5 deficiency disorder: Two‐year open‐label extension follow‐up	20
A systematic review and meta‐analysis of ketamine in pediatric status epilepticus	20
Lacosamide decreases neonatal seizures without increasing apoptosis	20
Limbic and paralimbic respiratory modulation: From inhibition to enhancement	20
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Elevated photic response is followed by a rapid decay and depressed state in ictogenic networks	19
Long‐term evaluation of anterior thalamic deep brain stimulation for epilepsy in the European MORE registry	19
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Unsupervised clustering of a deeply phenotyped cohort of adults with idiopathic generalized epilepsy	19
Machine learning validation through decision tree analysis of the Epidemiology‐Based Mortality Score in Status Epilepticus	19
Trends in management of patients with new‐onset refractory status epilepticus (NORSE) from 2016 to 2023: An interim analysis	19
Vitamin D prophylaxis in persons with epilepsy?	19
Issue Information	19
Epilepsia – May 2023 – Announcements	19
Analysis of participant race and sex reporting and disparities in US epilepsy clinical trials	19
Phenotypic heterogeneity in familial epilepsies is influenced by polygenic risk for generalized and focal epilepsies	19
Not surgical technique, but etiology, contralateral MRI, prior surgery, and side of surgery determine seizure outcome after pediatric hemispherotomy	19
Satellite Symposium	19
Electroencephalographic source imaging of spikes with concurrent high‐frequency oscillations is concordant with the clinical ground truth	18
Neurological morbidity of surgery for suprasylvian operculoinsular epilepsy	18
Concordance between focal brain temperature elevations and focal edema in temporal lobe epilepsy	18
Distinct peripheral pro‐inflammatory profile associated with tuberous sclerosis complex and epilepsy	18
Practical considerations in epilepsy neurostimulation	18
Fast activity chirp patterns in focal seizures from patients and animal models	18
Issue Information	18
Add‐on treatment with cenobamate is already effective at low doses in refractory focal epilepsy: A prospective observational study	18
A knowledge synthesis of health research reporting standards relevant to epilepsy surgery	18
A systems medicine strategy to predict the efficacy of drugs for monogenic epilepsies	18
Community‐based epilepsy care in an onchocerciasis‐endemic area: A 3‐year cohort study in Mahenge, Tanzania	18
Assessing naming and verbal memory in bilingual epilepsy: Challenges and insights for surgical planning	18
Peri‐ictal respiratory dysfunction: Expanding the association between mTOR pathway disorders and ictal central apnea	18
Enlarged perivascular space in the temporal lobe as a prognostic marker in temporal lobe epilepsy with hippocampal sclerosis	18
Risk of recurrence in patients with an unprovoked tonic–clonic seizure and generalized epileptiform discharges on EEG	18
Antiseizure medications in the World Health Organization list of “essential medicines”	18
Putative roles for homeostatic plasticity in epileptogenesis	18
Plasma neurofilament heavy chain is a prognostic biomarker for the development of severe epilepsy after experimental traumatic brain injury	18
Anti‐γ‐aminobutyric acid B receptor autoimmune encephalitis: Clinical presentation and diagnostic insights	18
Epilepsia – September 2025 Announcements	18
Drug resistance in epilepsy: A reappraisal of the definition is needed	18
Semiautomatic interictal electric source localization based on long‐term electroencephalographic monitoring: A prospective study	17
Long‐term seizure and psychosocial outcomes of patients with ring chromosome 20 syndrome: A cohort study of 47 cases	17
Neurophotonic methods in approach to in vivo animal epileptic models: Advantages and limitations	17
Peripheral blood mononuclear cell secretome from patients with autoimmune encephalitis promotes seizures in vitro	17
Noninvasive mobile EEG as a tool for seizure monitoring and management: A systematic review	17
Sudden unexpected death in epilepsy during cenobamate clinical development	17
Neurobehavioral deficits and a progressive ictogenesis in the tetrodotoxin model of epileptic spasms	17
Effect of adenosinergic manipulations on amygdala‐kindled seizures in mice: Implications for sudden unexpected death in epilepsy	17
Using nirmatrelvir/ritonavir in patients with epilepsy: An update from the Israeli chapter of the International League Against Epilepsy	17
How often do caregivers attend their child when a seizure detection device alerts for a nocturnal major motor seizure?	17
Spectrum of epileptogenicity in different cortical tuber radiological subtypes: A stereoelectroencephalographic study	17
Quantitative analysis of visually reviewed normal scalp EEG predicts seizure freedom following anterior temporal lobectomy	17
Detection of focal cortical dysplasia: Development and multicentric evaluation of artificial intelligence models	17
Clinical seizure semiology is subtle and identification of seizures by parents is unreliable in infants with tuberous sclerosis complex	17
Introduction to the epilepsy syndrome papers	17
Visually or auditorily induced seizures involve the activation of nonhippocampal brain areas and hippocampal removal does not alleviate seizures in a mouse model of temporal lobe epilepsy	17
Epilepsia – June 2024 Announcements	17
Epilepsy in cerebral amyloid angiopathy: an observational retrospective study of a large population	17
Chemogenetic astrocyte modulation reduces spontaneous hippocampal discharges and metabolite changes in an epilepsy mouse model	17
Evaluating crowdsourcing for ICU EEG annotation: A comparison with expert performance	17
Epilepsia – February 2022 – Announcements	16
Brain molecular mechanisms in Rasmussen encephalitis	16
Telemedicine as a path to bridging inequities in patients with epilepsy	16
Issue Information	16
Seizures in anti‐Hu–associated extra‐limbic encephalitis: Characterization of a unique disease manifestation	16
Potential role of regulatory DNA variants in modifying the risk of severe cutaneous reactions induced by aromatic anti‐seizure medications	16
Insights into familial adult myoclonus epilepsy pathogenesis: How the same repeat expansion in six unrelated genes may lead to cortical excitability	16
Bridged bicyclic compounds: Comprehending a novel compound class as potential anti‐seizure agents	16
Proof of concept: Portable ultra‐low‐field magnetic resonance imaging for the diagnosis of epileptogenic brain pathologies	16
Epilepsia – December 2021 – Announcements	16
Revisiting the concept of drug‐resistant epilepsy: A TASK1 report of the ILAE/AES Joint Translational Task Force	16
Identification of a new retigabine derivative with improved photostability for selective activation of neuronal Kv7 channels and antiseizure activity	16
Evidence supporting deep brain stimulation of the medial septum in the treatment of temporal lobe epilepsy	16
Stimulation better targets fast‐ripple generating networks in super responders to the responsive neurostimulator system	16
Epilepsia – September 2023 – Announcements	16
Methodology for classification and definition of epilepsy syndromes with list of syndromes: Report of the ILAE Task Force on Nosology and Definitions	16
Clinical phenotypic spectrum of NRXN1 microdeletions and their association with epilepsy: A system	16
Integrated care for mental health in epilepsy: A systematic review and meta‐synthesis by the International League Against Epilepsy Integrated Mental Health Care Pathways Task Force	16
Topographical map of subjective states evoked by focal seizures and electrical stimulation of the human insula	16
An interview with Riccardo De Feo, 2023 Epilepsia Prize winner for Basic Science Research	16
WONOEP appraisal: Genetic insights into early onset epilepsies	16
Seizure outcomes after resection of temporal encephalocele in patients with drug‐resistant epilepsy: A systematic review and meta‐analysis	16
Age‐associated differences in FIRES: Characterizing prodromal presentation and long‐term outcomes via the web‐based NORSE/FIRES Family Registry	15