Epilepsia

Article	Citations
	351
Comment on: Failure to use new breakthrough treatments for epilepsy	161
Excitatory–inhibitory mismatch shapes node recruitment in an epileptic network	145
Optimizing external validation of deep neural networks for interictal discharge detection	136
Cytomegalic parvalbumin neurons in fetal cases of hemimegalencephaly	130
Unmasking the role of the occipital lobe in epilepsy with eyelid myoclonia	113
Evaluating the efficacy of prototype antiseizure drugs using a preclinical pharmacokinetic approach	90
Reasons for ineligibility for clinical trials of patients with medication‐resistant epilepsy	88
Topiramate ban in women of childbearing potential with idiopathic generalized epilepsy: Does effectiveness offset the teratogenic risks?	84
Surgical outcomes and motor function in pediatric peri‐Rolandic epilepsy: A single center's experience with 152 cases	78
Screening for depression in patients with epilepsy: What are the benefits for physicians and patients in the real‐life setting	72
Protective effect of CACNA1A deficiency in oligogenic refractory epilepsy with CACNA1A‐CELSR2 digenic mutations	65
Extreme cryptogenic new onset refractory status epilepticus/febrile infection‐related epilepsy syndrome: Evidence of profound neuroinflammation and neuronal injury	65
Response to Singh et al. 2023: It is premature for a unified hypothesis of sudden unexpected death in epilepsy: A great amount of research is still needed to understand the multisystem cascade	63
Author index	58
Targeting interictal low‐entropy zones during epilepsy surgery predicts successful outcomes in pediatric drug‐resistant epilepsy	57
Response: Reconsidering nonconvulsive status epilepticus diagnosis: 2.5‐Hz or etiology‐driven frequency cutoffs?	57
Impact of epilepsy on people experiencing homelessness: A mixed‐methods study	54
SCN8A self‐limited infantile epilepsy: Does epilepsy resolve?	53
Fast cycle of vagus nerve stimulation is associated with increased sleep‐related breathing disorder in patients with epilepsy	53
Preclinical signal for a disease‐modifying effect on seizure cluster severity with intermittent diazepam treatment	53
Long‐term prognosis of pharmacotherapy in newly diagnosed focal epilepsy patients and the predictive value of baseline seizure timing: A prospective cohort study	52
Epilepsy treatment over time: The chess game analogy for choosing, adjusting, and adding antiseizure medications	52
Artificial intelligence for adaptive neuromodulation in drug‐resistant epilepsy	52
Neurocardiac pathologies associated with potassium channelopathies	51

The transcriptomic signature of DEPDC5 KO induced mTOR hyperactivation in human neurons and its re	50
Intracerebroventricular administration for delivery of antiseizure therapeutics: Challenges and opportunities	50
PAC ‐ FOS: A novel translational concordance framework identifies preclinical seizure models with highest predictive v	50
Delayed excitability recovery and downregulation of neurodevelopmental pathways contribute to phenotypic differences in KCNQ2	50
Seizure outcomes in persons with autism spectrum disorder undergoing epilepsy surgery: A systematic review and meta‐analysis	49
Stage 1 Plus: A phenotype‐based framework for rational polytherapy in status epilepticus	48
Olig2‐specific loss‐of‐function Slc35a2 results in hypomyelination and spontaneous seizures	48
Tissue oxygenation dynamics during transition from seizure to spreading depolarization in rat brain	47
Validation of the International League Against Epilepsy ( ILAE ) Risk of Bias Tool against the Newcastle–Ottawa Scale in epilepsy research	47
Optimizing pediatric status epilepticus management: The role of early midazolam infusion and adherence to clinical practice guidelines	46
Decision‐making in stereotactic epilepsy surgery	45
Clinical effectiveness, feasibility, acceptability, and usability of mobile health applications for epilepsy: A systematic review	44
Scalp high‐frequency oscillation spatial distribution is consistent over consecutive nights, while rates vary with antiseizure medication changes	44
Role of cholesterol in modulating brain hyperexcitability	44
Statistical learning in epilepsy: Behavioral and anatomical mechanisms in the human brain	44
Prediction of long‐term unprovoked seizures after status epilepticus	43
Extended follow‐up after anterior temporal lobectomy demonstrates seizure recurrence 20+ years postsurgery	43
Cognitive stagnation and executive function deficits in young children with SCN1A + Dravet syndrom	43
Forty‐hertz sensory entrainment impedes kindling epileptogenesis and reduces amyloid pathology in an Alzheimer disease mouse model	43
Epilepsia – January 2023 – Announcements	42
Hippocampal sclerosis and temporal lobe epilepsy following febrile status epilepticus: The FEBSTAT study	42
Sleep, oscillations, and epilepsy	42
Long‐term neuroplasticity in language networks after anterior temporal lobe resection	42
Seizure clusters: Practical aspects and clinical strategies to care for patients in the community	40
Verbal fluency functional magnetic resonance imaging detects anti‐seizure effects and affective side effects of perampanel in people with focal epilepsy	40
The nuances of immunotherapy for NORSE/FIRES	40
Optimal approach to standardized documentation in epilepsy clinics: A scoping review	39
It is premature for a unified hypothesis of sudden unexpected death in epilepsy: A great amount of research is still needed to understand the multisystem cascade	39
Integrated genotype–phenotype function analysis reveals distinct pathogenic mechanisms for cognitive impairment in KCNQ2	38
Clinical adult outcome 11–30 years after pediatric epilepsy surgery: Complications and other surgical adverse events, seizure control, and cure of epilepsy	38
Seizure freedom after surgical resection of diffusion‐weighted magnetic resonance imaging abnormalities	37
Dissociation in functional/dissociative seizures: Alignment with neurobiology across the lifespan	37
Reply to: Optimizing external validation of deep neural networks for interictal discharge detection	36
Development of a preclinical testing platform for clinically relevant therapy for Dravet syndrome	36
Phase 1 study of ABI ‐009 ( nab ‐rapamycin) for surgically refractory epilepsy ( <	35
Issue Information	35
Asymmetry of generalized discharges in idiopathic generalized epilepsy in adults	34
Identification of a mosaic MTOR variant in purified neuronal DNA in a patient with focal cortical dysp	34
Low diagnostic yield of presurgical genetic testing in adult patients with epilepsy	34
Pseudoaneurysms as a complication of stereoelectroencephalography: Case series and clinical recommendations	33
Association of baseline sleep duration and sleep quality with seizure recurrence in newly treated patients with epilepsy	33
Increasing challenges to trial recruitment and conduct over time	33
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Feasibility of and patient satisfaction with Readiness Brain Operation Optimization Training, a manualized cognitive prehabilitation program for epilepsy surgery	33
Effect of epileptogenesis on hypercapnic cardioventilatory response in kainic acid rats	32
Spindle density relates to cognitive outcomes in infantile epileptic spasms syndrome with unknown etiology: A retrospective cohort study	32
Quantifying hubness to predict surgical outcomes in epilepsy: Assessing resection‐hub alignment in interictal intracranial EEG networks	32
Localized cortical morphometric and structural covariance differences in adolescents with functional/dissociative seizures	32
Decoding polymorphous low‐grade neuroepithelial tumor of the young (PLNTY): Electroclinical features and molecular signatures in epilepsy surgery candidates	32
Cerebral vascular and blood brain–barrier abnormalities in a mouse model of epilepsy and tuberous sclerosis complex	31

Statistical characteristics of large‐scale objective tonic–clonic seizure records from medical smartwatches used in daily life	31
Altered thalamic connectivity patterns in pediatric temporal lobe epilepsy: A gradient mapping study	31
Adherence patterns in antiseizure medications influencing risk of sudden unexplained death in epilepsy: A data linkage study using dispensed prescriptions	31
Did the French pregnancy pictogram change antiseizure medication use during pregnancy?	31
Predictive power of phase 1 studies for the identification of seizure onset zone in phase 2 in a pediatric epilepsy cohort	31
Ablation of cerebellar Purkinje cells enhances seizure susceptibility and promotes kindling	31
Flexible realistic simulation of seizure occurrence recapitulating statistical properties of seizure diaries	31
Paroxysmal slow wave events as a diagnostic biomarker for epilepsy: Lessons from rural Zambia	30
High‐dose folic acid use and cancer risk in women who have given birth: A register‐based cohort study	30
Scoping review and expert‐based consensus recommendations for assessment and management of psychogenic non‐epileptic (functional) seizures (PNES) in children: A report from the Pediatric Ps	29
Responsive stimulation of the thalamus for idiopathic generalized epilepsy: Results of the randomized controlled NAUTILUS trial through 18 months	29
A prospective natural history study protocol for clinical trial readiness in synaptic disorders	29
No association between histopathology and neurophysiology in surgical specimens from pediatric focal epilepsy patients	29
Analysis of practical judgment in older adults with epilepsy: An exploratory, multicenter cohort study	29
On‐scalp magnetoencephalography based on optically pumped magnetometers to investigate temporal lobe epilepsy	29
Obstructive sleep apnea in people with epilepsy: Modifying risk	28
Assisted reproduction and the fetal malformation risk associated with antiseizure medication exposure in pregnancy	28
A randomized phase 2b efficacy study in patients with seizure episodes with a predictable pattern using Staccato® alprazolam for rapid seizure termination	28
Health‐related quality of life in adults with drug‐resistant focal epilepsy treated with modified Atkins diet in a randomized clinical trial	28
Altered amygdala volumes and microstructure in focal epilepsy patients with tonic–clonic seizures, ictal, and post‐convulsive central apnea	28
MEG abnormalities and mechanisms of surgical failure in neocortical epilepsy	28
Diet composition and sterilization modifies intestinal microbiome diversity and burden of Theiler's virus infection–induced acute seizures	28
Underutilization of syndrome‐specific ICD ‐10 codes for genetic epilepsies: Implications for precision medicine	27
Decreased uncinate fasciculus integrity in functional seizures following traumatic brain injury	27
Acute effects of anti‐seizure medications on network level dynamics: A systematic comparison using multielectrode arrays	27
Epilepsy phenotype and its reproducibility after lateral fluid percussion‐induced traumatic brain injury in rats: Multicenter EpiBioS4Rx study project 1	27
Pharmacokinetic variability and use of therapeutic drug monitoring of cannabidiol in patients with refractory epilepsy	27
Home recording of 3‐Hz spike–wave discharges in adults with absence epilepsy using the wearable Sensor Dot	27
Perampanel as precision therapy in rare genetic epilepsies	26
Cardiac remodeling and arrhythmia in a mouse model of Depdc5 haploinsufficiency	26
Socioeconomic status and epilepsy surgery in the United States: Timing and outcomes	26
Can biomarkers of the epileptogenic zone be characterized in patients rendered seizure‐free alone?	26
Rapid eye movement sleep affects interictal epileptic activity differently in mesiotemporal and neocortical areas	26
Evaluation of limbic microstructural abnormalities in temporal lobe epilepsy: A neurite orientation distribution and density imaging study	26
Issue Information	26
Author Index	26
A phase 3, randomized clinical trial of soticlestat as adjunctive therapy for Lennox–Gastaut syndrome	26
Clinician knowledge gaps in epilepsy surgery: An international survey across 18 countries or regions in Asia–Oceania	26
Extracting epilepsy‐related information from unstructured clinic letters using large language models	25
Zebrafish models of developmental epileptic encephalopathy accurately reflect clinical electrographic biomarkers	25
Evolution of the European Medicines Agency clinical guidelines for epilepsy drug development between 2010 and 2025: A comparative analysis by the ILAE	25
Heterozygous GABAA receptor β3 subunit N110D knock‐in mice have epileptic spasms	25
Thalamic connectivity mirrors spatial maps of network dysfunction in nonlesional focal epilepsy	25
Climate change: Attitudes and concerns of, and learnings from, people with neurological conditions, carers, and health care professionals	25
Cenobamate efficacy in specific populations	25
Genetic testing for familial epilepsies: Diagnostic yield and genetic findings	25
Modification of brain conductivity in human focal epilepsy: A model‐based estimation from stereoelectroencephalography	24
Corrigendum	24
Early response rates with adjunctive cenobamate in uncontrolled focal seizures: Prospective analysis of a randomized, double‐blind, placebo‐controlled study in a multinational Asian population	24
Can the large language model ChatGPT ‐4omni predict outcomes in adult patients with status epilepticus?	24
Surfaced‐based detection of focal cortical dysplasia using magnetic resonance fingerprinting and machine learning	24
Excess health care use is significantly and persistently reduced following diagnosis of late‐onset epilepsy	24
Splicing variants in DEPDC5 ‐related epilepsies: From functional characterization to correction	24
Neurodevelopmental trajectories and clinical outcomes following ultra‐early epilepsy surgery in infants: A matched cohort study	24
Patients carrying pathogenic SCN8A variants with loss‐ and gain‐of‐function effects can be classified into five subgroups exhibiting varying developmental and epileptic components of	24
Paroxysmal fast activity is a biomarker of treatment response in deep brain stimulation for Lennox–Gastaut syndrome	24
Issue Information	24
Outcomes of the second withdrawal of anti‐seizure medication in patients with pediatric‐onset epilepsy	24
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Seizure characteristics and outcomes in patients with neurological conditions related to high‐risk paraneoplastic antibodies	24
Issue Information	24
Correction to “Health care utilization of Hispanic/Latino veterans with epilepsy: A national population‐based study”	24
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Potassium–chloride cotransporter 2 activity dampens induced ictal‐like activity in neocortical slices containing the seizure propagation zone of temporal lobe epilepsy patients	23
Development and preclinical evaluation of a hybrid stereoelectroencephalographic –laser depth electrode for magnetic resonance imaging‐guided interst	23
Efficacy of cannabidiol in convulsive and nonconvulsive seizure types associated with treatment‐resistant epilepsies in the Expanded Access Program	23
Quantitative EEG biomarkers for STXBP1‐related disorders	23
Reliability and diagnostic accuracy of home video recording in differentiating sleep‐related hypermotor epilepsy from disorders of arousal	23
Hemispheric surgery for hemimegalencephaly and hemispheric cortical dysplasia in infants below 12 months of age—A single‐center experience	23
Differential outcomes in familial and sporadic SCN8A self‐limited infantile epilepsies: Insights from a large international registry	23
Metabolomic changes in adults with status epilepticus: A human case–control study	23
Leveraging expertise and optimizing clinical research: Initial success of a pediatric epilepsy surgery collaborative	23
Antiseizure medication and perceived “fair” cost allocation: A factorial survey among neurologists, persons with epilepsy, their relatives, and a control group	23
Efficacy and safety of perampanel in patients with seizures associated with Lennox–Gastaut syndrome: A randomized trial	23
Racial/ethnic differences in the association of incident stroke with late onset epilepsy: The Northern Manhattan Study	23
Spike patterns surrounding sleep and seizures localize the seizure‐onset zone in focal epilepsy	22
Seizure monitoring by combined diary and wearable data: A multicenter, longitudinal, observational study	22
Epilepsia – January 2025 Announcements	22
Farewell from the Editor‐in‐Chief	22
Epilepsy expands the phenotype of L‐arginine:glycine amidinotransferase deficiency	22

Emerging translocator protein–positron emission tomographic imaging improves detection of focal cortical dysplasia	22
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Response: Drug resistance in epilepsy: A reappraisal of the definition is needed	22
Primidone improves symptoms in TRPM3‐linked developmental and epileptic encephalopathy with spike‐and‐wave activation in sleep	22
Long‐read sequencing of recurrent FGF12 duplications in epilepsy: Insights into structural mechanisms and aberrant isoforms	22
Prognostic scores in status epilepticus: A systematic review and meta‐analysis	22
Issue Information	22
Epilepsia—October 2023—Announcements	22
Sustained rescue of seizure control in patients with highly refractory chronic epilepsy using empiric immunotherapy	21
Response: “What is the risk of unprovoked seizures after acute symptomatic status epilepticus?”	21
Amitriptyline use in individuals with KCNQ2/3 gain‐of‐function variants: A retrospective cohort study	21
Deep characterization of refractory epilepsy due to mild malformation of cortical development with oligodendroglial hyperplasia ( MOGHE ) and insight	21
Correction to “patterns of subregional cerebellar atrophy across epilepsy syndromes: An ENIGMA—Epilepsy study”	21
Machine learning validation through decision tree analysis of the Epidemiology‐Based Mortality Score in Status Epilepticus	21
Phenotypic heterogeneity in familial epilepsies is influenced by polygenic risk for generalized and focal epilepsies	21
Mesial‐to‐lateral gradients of epileptiform activity to localize mesial temporal lobe epilepsy	21
Quantifying the impact of a computer‐aided diagnostic score on the clinical diagnosis of functional seizures	20
Applicability and feasibility of the updated ILAE seizure classification in secondary referral centers	20
Tracing topics and trends in drug‐resistant epilepsy research using a natural language processing–based topic modeling approach	20
Long‐term treatment with ganaxolone for seizures associated with cyclin‐dependent kinase‐like 5 deficiency disorder: Two‐year open‐label extension follow‐up	20
Hippocampal malformation in Dravet syndrome	20
Attenuation of initial pilocarpine‐induced electrographic seizures by methionine sulfoximine pretreatment tightly correlates with the reduction of extracellular taurine in the hippocampus	20
Learning to generalize seizure forecasts	20
A systematic review and meta‐analysis of ketamine in pediatric status epilepticus	20
Peak width of skeletonized mean diffusivity as a marker of small vessel disease in patients with temporal lobe epilepsy with hippocampal sclerosis	20
Early seizure freedom with [ 18 F ]fluorodopa positron emission tomograp	20
Clioquinol as a new therapy in epilepsy: From preclinical evidence to a proof‐of‐concept clinical study	20
A novel PTEN variant causing hemimegalencephaly and focal nodular heterotopias in the developing h	20
Fluoxetine accelerates epileptogenesis and magnifies disease severity in a rat model of acquired epilepsy	20
Comparison of children and adults undergoing subdural grid electrode implantation or stereoelectroencephalography in a refractory epilepsy cohort from four European centers	20
Elevated photic response is followed by a rapid decay and depressed state in ictogenic networks	20
Early life seizures and epileptic spasms in STXBP1‐related disorders	20
Value of ultra‐high‐field MRI in patients with drug‐resistant focal epilepsy and negative 3T MRI (	20
Lacosamide decreases neonatal seizures without increasing apoptosis	20
Epilepsia – January 2026 Announcements	20
Creating rare epilepsy cohorts using keyword search in electronic health records	20
Hippocampal atrophy and functional plasticity underlie cognitive outcome in anti‐leucine‐rich glioma‐inactivated protein 1 encephalitis and their clinical correlates	20
Role of vitamin D supplementation and vitamin D receptor in drug‐resistant epilepsy: A double‐blind placebo‐controlled trial conducted in India	20
Refining diagnostic boundaries and electroclinical profiles of Lennox–Gastaut syndrome through unsupervised clustering	20
The “make or break” impact of family dynamics on psychological outcomes in focal epilepsy	19
Unsupervised clustering of a deeply phenotyped cohort of adults with idiopathic generalized epilepsy	19
Telemedicine as a path to bridging inequities in patients with epilepsy	19
Neurobehavioral deficits and a progressive ictogenesis in the tetrodotoxin model of epileptic spasms	19
Plasma neurofilament heavy chain is a prognostic biomarker for the development of severe epilepsy after experimental traumatic brain injury	19
Increased uptake of the P2X7 receptor radiotracer 18F‐JNJ‐64413739 in the brain and peripheral organs according to the severity of status epilepticus in male mice	19
The need for an individualized approach to what is considered a clinically significant reduction in seizure frequency: A patient's perspective	19
Trends in management of patients with new‐onset refractory status epilepticus (NORSE) from 2016 to 2023: An interim analysis	19
Vitamin D prophylaxis in persons with epilepsy?	19
Epilepsia – May 2023 – Announcements	19
Electroencephalographic findings and 5‐year risk of posttraumatic epilepsy after mild traumatic brain injury: Insights from Second Karabakh War veterans	19
Electroencephalographic source imaging of spikes with concurrent high‐frequency oscillations is concordant with the clinical ground truth	19
Issue Information	19
Not surgical technique, but etiology, contralateral MRI, prior surgery, and side of surgery determine seizure outcome after pediatric hemispherotomy	19
Efficacy of neuromodulation of the pulvinar nucleus for drug‐resistant epilepsy	19
Haploinsufficiency of brain‐specific kinase BRSK1 causes epilepsy and neurodevelopmental disorders	19
Predicting posttraumatic epilepsy using admission electroencephalography after severe traumatic brain injury	19
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Issue Information	19
Dynamic patterns of verbal memory function after an initial decline following temporal lobe resection against epilepsy: Sex‐specific differences in the postoperative course	19
Abstracts	19
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Long‐term evaluation of anterior thalamic deep brain stimulation for epilepsy in the European MORE registry	19
Incidence and risk factors of posttraumatic epilepsy following pediatric traumatic brain injury: A systematic review and meta‐analysis	19
Satellite Symposium	19
Latent class analysis of eHealth behaviors among adults with epilepsy	19
Epilepsia – September 2025 Announcements	18
Bridged bicyclic compounds: Comprehending a novel compound class as potential anti‐seizure agents	18
Risk of recurrence in patients with an unprovoked tonic–clonic seizure and generalized epileptiform discharges on EEG	18
Distinct peripheral pro‐inflammatory profile associated with tuberous sclerosis complex and epilepsy	18
Peripheral blood mononuclear cell secretome from patients with autoimmune encephalitis promotes seizures in vitro	18
Drug resistance in epilepsy: A reappraisal of the definition is needed	18
Lactate receptor HCAR1 in neonatal hypoxic–ischemic seizures	18
Issue Information	18
Antiseizure medications in the World Health Organization list of “essential medicines”	18
A systems medicine strategy to predict the efficacy of drugs for monogenic epilepsies	18
Epilepsy in cerebral amyloid angiopathy: an observational retrospective study of a large population	18
Neurophotonic methods in approach to in vivo animal epileptic models: Advantages and limitations	18
Spectrum of epileptogenicity in different cortical tuber radiological subtypes: A stereoelectroencephalographic study	17
Neurological morbidity of surgery for suprasylvian operculoinsular epilepsy	17
Arterial spin labeling performs comparably to 2‐[ 18 F]fluoro‐2‐deoxy‐D‐glucose positron emission tomography for presu	17
Epilepsia – June 2024 Announcements	17
Pyruvate dehydrogenase autoantibodies in autoantibody‐negative patients with seizures are associated with reduced pyruvate dehydrogenase activity	17
A knowledge synthesis of health research reporting standards relevant to epilepsy surgery	17
Enlarged perivascular space in the temporal lobe as a prognostic marker in temporal lobe epilepsy with hippocampal sclerosis	17
Factors associated with long‐term outcomes in people with new onset refractory epilepticus: A single‐center cohort study	17
Do we agree on seizure reduction after vagus nerve stimulation? Interrater reliability of retrospective and prospective seizure frequency ratings from the CONNECTiVOS	17
Community‐based epilepsy care in an onchocerciasis‐endemic area: A 3‐year cohort study in Mahenge, Tanzania	17
Effect of adenosinergic manipulations on amygdala‐kindled seizures in mice: Implications for sudden unexpected death in epilepsy	17
Chemogenetic astrocyte modulation reduces spontaneous hippocampal discharges and metabolite changes in an epilepsy mouse model	17
Anti‐γ‐aminobutyric acid B receptor autoimmune encephalitis: Clinical presentation and diagnostic insights	17
Integrated care for mental health in epilepsy: A systematic review and meta‐synthesis by the International League Against Epilepsy Integrated Mental Health Care Pathways Task Force	17
Clinical seizure semiology is subtle and identification of seizures by parents is unreliable in infants with tuberous sclerosis complex	17
Evaluating crowdsourcing for ICU EEG annotation: A comparison with expert performance	17
Clinical phenotypic spectrum of NRXN1 microdeletions and their association with epilepsy: A system	17
Detection of focal cortical dysplasia: Development and multicentric evaluation of artificial intelligence models	17