Epilepsia

Article	Citations
	711
PAC‐FOS: A novel translational concordance framework identifies preclinical seizure models with highest predictive validity for clinical focal onset seizures	700
Targeting interictal low‐entropy zones during epilepsy surgery predicts successful outcomes in pediatric drug‐resistant epilepsy	349
Seizure outcomes in persons with autism spectrum disorder undergoing epilepsy surgery: A systematic review and meta‐analysis	270
Excitatory–inhibitory mismatch shapes node recruitment in an epileptic network	217
Comment on: Failure to use new breakthrough treatments for epilepsy	211
Optimizing pediatric status epilepticus management: The role of early midazolam infusion and adherence to clinical practice guidelines	188
The transcriptomic signature of DEPDC5 KO induced mTOR hyperactivation in human neurons and its re	173
Forty‐hertz sensory entrainment impedes kindling epileptogenesis and reduces amyloid pathology in an Alzheimer disease mouse model	134
Unmasking the role of the occipital lobe in epilepsy with eyelid myoclonia	130
Topiramate ban in women of childbearing potential with idiopathic generalized epilepsy: Does effectiveness offset the teratogenic risks?	120
Impact of epilepsy on people experiencing homelessness: A mixed‐methods study	116
Sustained seizure freedom with adjunctive brivaracetam in patients with focal onset seizures	109
Olig2‐specific loss‐of‐function Slc35a2 results in hypomyelination and spontaneous seizures	107
Cognitive stagnation and executive function deficits in young children with SCN1A + Dravet syndrom	106
Protective effect of CACNA1A deficiency in oligogenic refractory epilepsy with CACNA1A‐CELSR2 digenic mutations	103
Epilepsy treatment over time: The chess game analogy for choosing, adjusting, and adding antiseizure medications	103
Optimizing external validation of deep neural networks for interictal discharge detection	94
Surgical outcomes and motor function in pediatric peri‐Rolandic epilepsy: A single center's experience with 152 cases	90
Cytomegalic parvalbumin neurons in fetal cases of hemimegalencephaly	89
Reconsidering nonconvulsive status epilepticus diagnosis: 2.5‐Hz or etiology‐driven frequency cutoffs?	84
Delayed excitability recovery and downregulation of neurodevelopmental pathways contribute to phenotypic differences in KCNQ2‐related disorders	72
Response to Singh et al. 2023: It is premature for a unified hypothesis of sudden unexpected death in epilepsy: A great amount of research is still needed to understand the multisystem cascade	72
Role of cholesterol in modulating brain hyperexcitability	69
Sleep, oscillations, and epilepsy	67

Long‐term neuroplasticity in language networks after anterior temporal lobe resection	66
Hippocampal sclerosis and temporal lobe epilepsy following febrile status epilepticus: The FEBSTAT study	66
Scalp high‐frequency oscillation spatial distribution is consistent over consecutive nights, while rates vary with antiseizure medication changes	65
Anticonvulsive properties of soticlestat, a novel cholesterol 24‐hydroxylase inhibitor	57
Neurocardiac pathologies associated with potassium channelopathies	56
Reasons for ineligibility for clinical trials of patients with medication‐resistant epilepsy	55
Screening for depression in patients with epilepsy: What are the benefits for physicians and patients in the real‐life setting	53
Statistical learning in epilepsy: Behavioral and anatomical mechanisms in the human brain	52
SCN8A self‐limited infantile epilepsy: Does epilepsy resolve?	52
Clinical effectiveness, feasibility, acceptability, and usability of mobile health applications for epilepsy: A systematic review	51
Extended follow‐up after anterior temporal lobectomy demonstrates seizure recurrence 20+ years postsurgery	50
Decision‐making in stereotactic epilepsy surgery	49
Prediction of long‐term unprovoked seizures after status epilepticus	48
Evaluating the efficacy of prototype antiseizure drugs using a preclinical pharmacokinetic approach	47
Intracerebroventricular administration for delivery of antiseizure therapeutics: Challenges and opportunities	46
Author index	46
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Epilepsia – January 2023 – Announcements	45
The nuances of immunotherapy for NORSE/FIRES	44
No association between histopathology and neurophysiology in surgical specimens from pediatric focal epilepsy patients	44
Predictive power of phase 1 studies for the identification of seizure onset zone in phase 2 in a pediatric epilepsy cohort	43
Quantifying hubness to predict surgical outcomes in epilepsy: Assessing resection‐hub alignment in interictal intracranial EEG networks	43
Issue Information	41
Reply to: Optimizing external validation of deep neural networks for interictal discharge detection	41
It is premature for a unified hypothesis of sudden unexpected death in epilepsy: A great amount of research is still needed to understand the multisystem cascade	39
Issue Information	39
Effect of levetiracetam on the gene expression of placental transporters in a murine model	39
Analysis of practical judgment in older adults with epilepsy: An exploratory, multicenter cohort study	39
Decreased uncinate fasciculus integrity in functional seizures following traumatic brain injury	39
Association of baseline sleep duration and sleep quality with seizure recurrence in newly treated patients with epilepsy	38
Pseudoaneurysms as a complication of stereoelectroencephalography: Case series and clinical recommendations	37
Feasibility of and patient satisfaction with Readiness Brain Operation Optimization Training, a manualized cognitive prehabilitation program for epilepsy surgery	37
Phase 1 study of ABI ‐009 ( nab ‐rapamycin) for surgically refractory epilepsy ( <	37
Development of a preclinical testing platform for clinically relevant therapy for Dravet syndrome	37
Seizure clusters: Practical aspects and clinical strategies to care for patients in the community	36
Scoping review and expert‐based consensus recommendations for assessment and management of psychogenic non‐epileptic (functional) seizures (PNES) in children: A report from the Pediatric Ps	36
Identification of a mosaic MTOR variant in purified neuronal DNA in a patient with focal cortical dysp	36
Pharmacokinetic variability and use of therapeutic drug monitoring of cannabidiol in patients with refractory epilepsy	36
Verbal fluency functional magnetic resonance imaging detects anti‐seizure effects and affective side effects of perampanel in people with focal epilepsy	35
Altered thalamic connectivity patterns in pediatric temporal lobe epilepsy: A gradient mapping study	35
Cerebral vascular and blood brain–barrier abnormalities in a mouse model of epilepsy and tuberous sclerosis complex	35
Health‐related quality of life in adults with drug‐resistant focal epilepsy treated with modified Atkins diet in a randomized clinical trial	35
On‐scalp magnetoencephalography based on optically pumped magnetometers to investigate temporal lobe epilepsy	35
Multicenter, cross‐sectional study of the costs of illness and cost‐driving factors in adult patients with epilepsy	35
Asymmetry of generalized discharges in idiopathic generalized epilepsy in adults	34
Adherence patterns in antiseizure medications influencing risk of sudden unexplained death in epilepsy: A data linkage study using dispensed prescriptions	34
Epilepsy phenotype and its reproducibility after lateral fluid percussion‐induced traumatic brain injury in rats: Multicenter EpiBioS4Rx study project 1	33
Seizure freedom after surgical resection of diffusion‐weighted magnetic resonance imaging abnormalities	32
Home recording of 3‐Hz spike–wave discharges in adults with absence epilepsy using the wearable Sensor Dot	32
Clinical adult outcome 11–30 years after pediatric epilepsy surgery: Complications and other surgical adverse events, seizure control, and cure of epilepsy	32

Diet composition and sterilization modifies intestinal microbiome diversity and burden of Theiler's virus infection–induced acute seizures	32
High‐dose folic acid use and cancer risk in women who have given birth: A register‐based cohort study	32
Assisted reproduction and the fetal malformation risk associated with antiseizure medication exposure in pregnancy	32
Genome‐wide decrease in DNA methylation in adults with epilepsy treated with modified ketogenic diet: A prospective study	32
MEG abnormalities and mechanisms of surgical failure in neocortical epilepsy	31
Altered amygdala volumes and microstructure in focal epilepsy patients with tonic–clonic seizures, ictal, and post‐convulsive central apnea	31
Cognitive phenotypes in frontal lobe epilepsy	31
A randomized phase 2b efficacy study in patients with seizure episodes with a predictable pattern using Staccato® alprazolam for rapid seizure termination	31
Machine learning approaches for imaging‐based prognostication of the outcome of surgery for mesial temporal lobe epilepsy	30
Statistical characteristics of large‐scale objective tonic–clonic seizure records from medical smartwatches used in daily life	30
Antiseizure medication and perceived “fair” cost allocation: A factorial survey among neurologists, persons with epilepsy, their relatives, and a control group	30
Flexible realistic simulation of seizure occurrence recapitulating statistical properties of seizure diaries	30
Paroxysmal slow wave events as a diagnostic biomarker for epilepsy: Lessons from rural Zambia	30
Increasing challenges to trial recruitment and conduct over time	30
Perampanel as precision therapy in rare genetic epilepsies	30
Seizure characteristics and outcomes in patients with neurological conditions related to high‐risk paraneoplastic antibodies	29
Can biomarkers of the epileptogenic zone be characterized in patients rendered seizure‐free alone?	29
Corrigendum	28
Potassium–chloride cotransporter 2 activity dampens induced ictal‐like activity in neocortical slices containing the seizure propagation zone of temporal lobe epilepsy patients	28
Author Index	28
Issue Information	27
Racial/ethnic differences in the association of incident stroke with late onset epilepsy: The Northern Manhattan Study	27
Excess health care use is significantly and persistently reduced following diagnosis of late‐onset epilepsy	27
Climate change: Attitudes and concerns of, and learnings from, people with neurological conditions, carers, and health care professionals	27
Quantitative EEG biomarkers for STXBP1‐related disorders	27
Issue Information	27
An interview with Margherita Contento, 2022 Epilepsia Prize winner for clinical research	27
Modification of brain conductivity in human focal epilepsy: A model‐based estimation from stereoelectroencephalography	26
Long‐read sequencing of recurrent FGF12 duplications in epilepsy: Insights into structural mechanisms and aberrant isoforms	26
Zebrafish models of developmental epileptic encephalopathy accurately reflect clinical electrographic biomarkers	26
Surfaced‐based detection of focal cortical dysplasia using magnetic resonance fingerprinting and machine learning	26
Correction to “Health care utilization of Hispanic/Latino veterans with epilepsy: A national population‐based study”	26
Can the large language model ChatGPT ‐4omni predict outcomes in adult patients with status epilepticus?	25
Splicing variants in DEPDC5 ‐related epilepsies: From functional characterization to correction	25
Combined electrophysiological and morphological phenotypes in patients with genetic generalized epilepsy and their healthy siblings	25
Patients carrying pathogenic SCN8A variants with loss‐ and gain‐of‐function effects can be classified into five subgroups exhibiting varying developmental and epileptic components of	25
Extracting epilepsy‐related information from unstructured clinic letters using large language models	25
Reliability and diagnostic accuracy of home video recording in differentiating sleep‐related hypermotor epilepsy from disorders of arousal	25
Epilepsy expands the phenotype of L‐arginine:glycine amidinotransferase deficiency	25
Efficacy of cannabidiol in convulsive and nonconvulsive seizure types associated with treatment‐resistant epilepsies in the Expanded Access Program	25
Differential outcomes in familial and sporadic SCN8A self‐limited infantile epilepsies: Insights from a large international registry	25
Leveraging expertise and optimizing clinical research: Initial success of a pediatric epilepsy surgery collaborative	25
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Evaluation of limbic microstructural abnormalities in temporal lobe epilepsy: A neurite orientation distribution and density imaging study	25
Reproduction and genetic causal attribution of epilepsy	25
Primidone improves symptoms in TRPM3‐linked developmental and epileptic encephalopathy with spike‐and‐wave activation in sleep	24
Cenobamate efficacy in specific populations	24
Outcomes of the second withdrawal of anti‐seizure medication in patients with pediatric‐onset epilepsy	24
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Spike patterns surrounding sleep and seizures localize the seizure‐onset zone in focal epilepsy	24
Metabolomic changes in adults with status epilepticus: A human case–control study	24
Using magnetic resonance fingerprinting to characterize periventricular nodular heterotopias in pharmacoresistant epilepsy	24
Seizure activity triggers tau hyperphosphorylation and amyloidogenic pathways	24
Seizure monitoring by combined diary and wearable data: A multicenter, longitudinal, observational study	24
Emerging translocator protein–positron emission tomographic imaging improves detection of focal cortical dysplasia	24
Early response rates with adjunctive cenobamate in uncontrolled focal seizures: Prospective analysis of a randomized, double‐blind, placebo‐controlled study in a multinational Asian population	24
Prognostic scores in status epilepticus: A systematic review and meta‐analysis	23
Paroxysmal fast activity is a biomarker of treatment response in deep brain stimulation for Lennox–Gastaut syndrome	23
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Heterozygous GABAA receptor β3 subunit N110D knock‐in mice have epileptic spasms	23
Epilepsia—October 2023—Announcements	23
Correction to “patterns of subregional cerebellar atrophy across epilepsy syndromes: An ENIGMA—Epilepsy study”	23
Rapid eye movement sleep affects interictal epileptic activity differently in mesiotemporal and neocortical areas	23
Efficacy and safety of perampanel in patients with seizures associated with Lennox–Gastaut syndrome: A randomized trial	23
Epilepsia – January 2025 Announcements	23
The “make or break” impact of family dynamics on psychological outcomes in focal epilepsy	22
Farewell from the Editor‐in‐Chief	22
Response: Drug resistance in epilepsy: A reappraisal of the definition is needed	22
Creating rare epilepsy cohorts using keyword search in electronic health records	22
Issue Information	22
Attenuation of initial pilocarpine‐induced electrographic seizures by methionine sulfoximine pretreatment tightly correlates with the reduction of extracellular taurine in the hippocampus	22
Peak width of skeletonized mean diffusivity as a marker of small vessel disease in patients with temporal lobe epilepsy with hippocampal sclerosis	22
Latent class analysis of eHealth behaviors among adults with epilepsy	22
Fluoxetine accelerates epileptogenesis and magnifies disease severity in a rat model of acquired epilepsy	22
Sustained rescue of seizure control in patients with highly refractory chronic epilepsy using empiric immunotherapy	22
Limbic and paralimbic respiratory modulation: From inhibition to enhancement	22
Comparison of children and adults undergoing subdural grid electrode implantation or stereoelectroencephalography in a refractory epilepsy cohort from four European centers	21
Lacosamide decreases neonatal seizures without increasing apoptosis	21
Haploinsufficiency of brain‐specific kinase BRSK1 causes epilepsy and neurodevelopmental disorders	21
Response: “What is the risk of unprovoked seizures after acute symptomatic status epilepticus?”	21

Long‐term evaluation of anterior thalamic deep brain stimulation for epilepsy in the European MORE registry	21
Trends in management of patients with new‐onset refractory status epilepticus (NORSE) from 2016 to 2023: An interim analysis	21
Mesial‐to‐lateral gradients of epileptiform activity to localize mesial temporal lobe epilepsy	21
Machine learning validation through decision tree analysis of the Epidemiology‐Based Mortality Score in Status Epilepticus	21
Value of ultra‐high‐field MRI in patients with drug‐resistant focal epilepsy and negative 3T MRI (EpiUltraStudy): Diagnostic gain of 7T structural analysis	21
Phenotypic heterogeneity in familial epilepsies is influenced by polygenic risk for generalized and focal epilepsies	20
Early seizure freedom with [ 18 F ]fluorodopa positron emission tomograp	20
Efficacy of neuromodulation of the pulvinar nucleus for drug‐resistant epilepsy	20
Elevated photic response is followed by a rapid decay and depressed state in ictogenic networks	20
A systematic review and meta‐analysis of ketamine in pediatric status epilepticus	20
Applicability and feasibility of the updated ILAE seizure classification in secondary referral centers	20
Amitriptyline use in individuals with KCNQ2/3 gain‐of‐function variants: A retrospective cohort study	20
Early life seizures and epileptic spasms in STXBP1‐related disorders	20
Role of vitamin D supplementation and vitamin D receptor in drug‐resistant epilepsy: A double‐blind placebo‐controlled trial conducted in India	20
The need for an individualized approach to what is considered a clinically significant reduction in seizure frequency: A patient's perspective	20
Tracing topics and trends in drug‐resistant epilepsy research using a natural language processing–based topic modeling approach	20
Predicting posttraumatic epilepsy using admission electroencephalography after severe traumatic brain injury	20
Clioquinol as a new therapy in epilepsy: From preclinical evidence to a proof‐of‐concept clinical study	20
Satellite Symposium	19
Learning to generalize seizure forecasts	19
Long‐term treatment with ganaxolone for seizures associated with cyclin‐dependent kinase‐like 5 deficiency disorder: Two‐year open‐label extension follow‐up	19
Anti‐γ‐aminobutyric acid B receptor autoimmune encephalitis: Clinical presentation and diagnostic insights	19
Distinct peripheral pro‐inflammatory profile associated with tuberous sclerosis complex and epilepsy	19
Bridged bicyclic compounds: Comprehending a novel compound class as potential anti‐seizure agents	19
Factors associated with long‐term outcomes in people with new onset refractory epilepticus: A single‐center cohort study	19
Issue Information	19
Incidence and risk factors of posttraumatic epilepsy following pediatric traumatic brain injury: A systematic review and meta‐analysis	19
Not surgical technique, but etiology, contralateral MRI, prior surgery, and side of surgery determine seizure outcome after pediatric hemispherotomy	19
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Assessing naming and verbal memory in bilingual epilepsy: Challenges and insights for surgical planning	19
Brain molecular mechanisms in Rasmussen encephalitis	19
Plasma neurofilament heavy chain is a prognostic biomarker for the development of severe epilepsy after experimental traumatic brain injury	19
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Increased uptake of the P2X7 receptor radiotracer 18F‐JNJ‐64413739 in the brain and peripheral organs according to the severity of status epilepticus in male mice	19
Epilepsia – May 2023 – Announcements	19
Vitamin D prophylaxis in persons with epilepsy?	19
Visually or auditorily induced seizures involve the activation of nonhippocampal brain areas and hippocampal removal does not alleviate seizures in a mouse model of temporal lobe epilepsy	19
Clinical phenotypic spectrum of NRXN1 microdeletions and their association with epilepsy: A system	19
Issue Information	19
Epilepsia – September 2025 Announcements	18
Neurological morbidity of surgery for suprasylvian operculoinsular epilepsy	18
Epilepsia – June 2024 Announcements	18
Fast activity chirp patterns in focal seizures from patients and animal models	18
Using nirmatrelvir/ritonavir in patients with epilepsy: An update from the Israeli chapter of the International League Against Epilepsy	18
A knowledge synthesis of health research reporting standards relevant to epilepsy surgery	18
A systems medicine strategy to predict the efficacy of drugs for monogenic epilepsies	18
Proof of concept: Portable ultra‐low‐field magnetic resonance imaging for the diagnosis of epileptogenic brain pathologies	18
Do we agree on seizure reduction after vagus nerve stimulation? Interrater reliability of retrospective and prospective seizure frequency ratings from the CONNECTiVOS	18
Peri‐ictal respiratory dysfunction: Expanding the association between mTOR pathway disorders and ictal central apnea	18
Enlarged perivascular space in the temporal lobe as a prognostic marker in temporal lobe epilepsy with hippocampal sclerosis	18
Antiseizure medications in the World Health Organization list of “essential medicines”	18
Neurobehavioral deficits and a progressive ictogenesis in the tetrodotoxin model of epileptic spasms	18
Analysis of participant race and sex reporting and disparities in US epilepsy clinical trials	18
Evaluating crowdsourcing for ICU EEG annotation: A comparison with expert performance	18
How often do caregivers attend their child when a seizure detection device alerts for a nocturnal major motor seizure?	18
Community‐based epilepsy care in an onchocerciasis‐endemic area: A 3‐year cohort study in Mahenge, Tanzania	18
Concordance between focal brain temperature elevations and focal edema in temporal lobe epilepsy	18
Drug resistance in epilepsy: A reappraisal of the definition is needed	18
Neurophotonic methods in approach to in vivo animal epileptic models: Advantages and limitations	17
Semiautomatic interictal electric source localization based on long‐term electroencephalographic monitoring: A prospective study	17
Integrated care for mental health in epilepsy: A systematic review and meta‐synthesis by the International League Against Epilepsy Integrated Mental Health Care Pathways Task Force	17
Add‐on treatment with cenobamate is already effective at low doses in refractory focal epilepsy: A prospective observational study	17
Noninvasive mobile EEG as a tool for seizure monitoring and management: A systematic review	17
Peripheral blood mononuclear cell secretome from patients with autoimmune encephalitis promotes seizures in vitro	17
Spectrum of epileptogenicity in different cortical tuber radiological subtypes: A stereoelectroencephalographic study	17
Chemogenetic astrocyte modulation reduces spontaneous hippocampal discharges and metabolite changes in an epilepsy mouse model	17
Putative roles for homeostatic plasticity in epileptogenesis	17
Detection of focal cortical dysplasia: Development and multicentric evaluation of artificial intelligence models	17
Telemedicine as a path to bridging inequities in patients with epilepsy	17
Risk of recurrence in patients with an unprovoked tonic–clonic seizure and generalized epileptiform discharges on EEG	17
Epilepsy in cerebral amyloid angiopathy: an observational retrospective study of a large population	17
Introduction to the epilepsy syndrome papers	17
Electroencephalographic source imaging of spikes with concurrent high‐frequency oscillations is concordant with the clinical ground truth	17
Long‐term seizure and psychosocial outcomes of patients with ring chromosome 20 syndrome: A cohort study of 47 cases	17
Clinical seizure semiology is subtle and identification of seizures by parents is unreliable in infants with tuberous sclerosis complex	17
Effect of adenosinergic manipulations on amygdala‐kindled seizures in mice: Implications for sudden unexpected death in epilepsy	17
Quantitative analysis of visually reviewed normal scalp EEG predicts seizure freedom following anterior temporal lobectomy	17
Unsupervised clustering of a deeply phenotyped cohort of adults with idiopathic generalized epilepsy	17
Practical considerations in epilepsy neurostimulation	17
Revisiting the concept of drug‐resistant epilepsy: A TASK1 report of the ILAE/AES Joint Translational Task Force	16
Methodology for classification and definition of epilepsy syndromes with list of syndromes: Report of the ILAE Task Force on Nosology and Definitions	16
Automated detection of interictal epileptiform discharges with few electroencephalographic channels	16
Effectiveness and implementation of an inpatient mental health care pathway at an epilepsy center: A prospective service evaluation	16
Automated detection of bottom‐of‐sulcus dysplasia on magnetic resonance imaging–positron emission tomography in patients with drug‐resistant focal epilepsy	16
Cross‐cultural application of the International Classification of Cognitive Disorders in Epilepsy (IC‐CoDE)	16
Epilepsia – September 2023 – Announcements	16
Incidence of sudden unexpected death in epilepsy in New Zealand: A prospective population‐wide, 2‐year study	16
Insights from stereoelectroencephalography in KCNT1 ‐related focal epilepsy suggest a multifocal a	16
Seizures and stigmas: Double burden on transgender health	16
Exogenous ketones exert antiseizure effects and modulate the gut microbiome and mycobiome in a clinically relevant murine model of epilepsy	16
Insights into familial adult myoclonus epilepsy pathogenesis: How the same repeat expansion in six unrelated genes may lead to cortical excitability	16
Pharmacokinetics and 180‐day safety of diazepam nasal spray in pediatric patients with epilepsy aged 2–5 years	16
Seizures in anti‐Hu–associated extra‐limbic encephalitis: Characterization of a unique disease manifestation	16
Association between pediatric traumatic brain injury and epilepsy at later ages in Finland: A nationwide register‐based cohort study	16
Stereo‐EEG–based ictal functional connectivity in patients with periventricular nodular heterotopia–related epilepsy	16