Epilepsia

Article	Citations
	509
Long‐term neuroplasticity in language networks after anterior temporal lobe resection	488
SCN8A self‐limited infantile epilepsy: Does epilepsy resolve?	263
	220
Excitatory–inhibitory mismatch shapes node recruitment in an epileptic network	157
Topiramate ban in women of childbearing potential with idiopathic generalized epilepsy: Does effectiveness offset the teratogenic risks?	153
	132
Comment on: Failure to use new breakthrough treatments for epilepsy	130
Erratum	96
Prediction of long‐term unprovoked seizures after status epilepticus	94
Cytomegalic parvalbumin neurons in fetal cases of hemimegalencephaly	91
Thank you to our Reviewers	88
Role of cholesterol in modulating brain hyperexcitability	84
Clinical effectiveness, feasibility, acceptability, and usability of mobile health applications for epilepsy: A systematic review	84
Self‐esteem mediates mental health outcomes in young people with epilepsy	81
Levetiracetam dosing in patients receiving continuous renal replacement therapy	80
Reasons for ineligibility for clinical trials of patients with medication‐resistant epilepsy	74
Protective effect of CACNA1A deficiency in oligogenic refractory epilepsy with CACNA1A‐CELSR2 digenic mutations	73
Response to Singh et al. 2023: It is premature for a unified hypothesis of sudden unexpected death in epilepsy: A great amount of research is still needed to understand the multisystem cascade	72
Neurocardiac pathologies associated with potassium channelopathies	72
Hippocampal sclerosis and temporal lobe epilepsy following febrile status epilepticus: The FEBSTAT study	68
Surgical outcomes and motor function in pediatric peri‐Rolandic epilepsy: A single center's experience with 152 cases	67
Forty‐hertz sensory entrainment impedes kindling epileptogenesis and reduces amyloid pathology in an Alzheimer disease mouse model	67
Evaluating the efficacy of prototype antiseizure drugs using a preclinical pharmacokinetic approach	65
Screening for depression in patients with epilepsy: What are the benefits for physicians and patients in the real‐life setting	64

Scalp high‐frequency oscillation spatial distribution is consistent over consecutive nights, while rates vary with antiseizure medication changes	64
Intracerebroventricular administration for delivery of antiseizure therapeutics: Challenges and opportunities	61
Statistical learning in epilepsy: Behavioral and anatomical mechanisms in the human brain	61
Anticonvulsive properties of soticlestat, a novel cholesterol 24‐hydroxylase inhibitor	60
Vitamin B status and association with antiseizure medication in pregnant women with epilepsy	58
Extended follow‐up after anterior temporal lobectomy demonstrates seizure recurrence 20+ years postsurgery	56
Sleep, oscillations, and epilepsy	55
Sustained seizure freedom with adjunctive brivaracetam in patients with focal onset seizures	55
Decision‐making in stereotactic epilepsy surgery	53
Effect of levetiracetam on the gene expression of placental transporters in a murine model	53
Cerebral vascular and blood brain–barrier abnormalities in a mouse model of epilepsy and tuberous sclerosis complex	52
Epilepsia – January 2023 – Announcements	52
Analysis of practical judgment in older adults with epilepsy: An exploratory, multicenter cohort study	51
Issue Information	51
A randomized phase 2b efficacy study in patients with seizure episodes with a predictable pattern using Staccato® alprazolam for rapid seizure termination	50
Statistical characteristics of large‐scale objective tonic–clonic seizure records from medical smartwatches used in daily life	49
Flexible realistic simulation of seizure occurrence recapitulating statistical properties of seizure diaries	47
Diet composition and sterilization modifies intestinal microbiome diversity and burden of Theiler's virus infection–induced acute seizures	46
It is premature for a unified hypothesis of sudden unexpected death in epilepsy: A great amount of research is still needed to understand the multisystem cascade	45
Scoping review and expert‐based consensus recommendations for assessment and management of psychogenic non‐epileptic (functional) seizures (PNES) in children: A report from the Pediatric Ps	45
Increasing challenges to trial recruitment and conduct over time	45
Clinical adult outcome 11–30 years after pediatric epilepsy surgery: Complications and other surgical adverse events, seizure control, and cure of epilepsy	45
Health‐related quality of life in adults with drug‐resistant focal epilepsy treated with modified Atkins diet in a randomized clinical trial	45
Mutations associated with epileptic encephalopathy modify EAAT2 anion channel function	45
Cognitive phenotypes in frontal lobe epilepsy	45
Association of baseline sleep duration and sleep quality with seizure recurrence in newly treated patients with epilepsy	45
Seizure clusters: Practical aspects and clinical strategies to care for patients in the community	43
Genome‐wide decrease in DNA methylation in adults with epilepsy treated with modified ketogenic diet: A prospective study	42
Machine learning approaches for imaging‐based prognostication of the outcome of surgery for mesial temporal lobe epilepsy	42
Assisted reproduction and the fetal malformation risk associated with antiseizure medication exposure in pregnancy	41
Pharmacokinetic variability and use of therapeutic drug monitoring of cannabidiol in patients with refractory epilepsy	41
High‐dose folic acid use and cancer risk in women who have given birth: A register‐based cohort study	41
The nuances of immunotherapy for NORSE/FIRES	40
Identification of a mosaic MTOR variant in purified neuronal DNA in a patient with focal cortical dysplasia using a novel depth electrode harvesting technique	39
Altered amygdala volumes and microstructure in focal epilepsy patients with tonic–clonic seizures, ictal, and post‐convulsive central apnea	39
Perampanel as precision therapy in rare genetic epilepsies	39
Home recording of 3‐Hz spike–wave discharges in adults with absence epilepsy using the wearable Sensor Dot	39
Long‐term individual retention with cenobamate in adults with focal seizures: Pooled data from the clinical development program	39
Quantifying hubness to predict surgical outcomes in epilepsy: Assessing resection‐hub alignment in interictal intracranial EEG networks	37
MEG abnormalities and mechanisms of surgical failure in neocortical epilepsy	37
Verbal fluency functional magnetic resonance imaging detects anti‐seizure effects and affective side effects of perampanel in people with focal epilepsy	37
Adherence patterns in antiseizure medications influencing risk of sudden unexplained death in epilepsy: A data linkage study using dispensed prescriptions	36
Decreased uncinate fasciculus integrity in functional seizures following traumatic brain injury	36
Multicenter, cross‐sectional study of the costs of illness and cost‐driving factors in adult patients with epilepsy	36
Epilepsy phenotype and its reproducibility after lateral fluid percussion‐induced traumatic brain injury in rats: Multicenter EpiBioS4Rx study project 1	36
Can biomarkers of the epileptogenic zone be characterized in patients rendered seizure‐free alone?	35
Long‐term safety of adjunctive cenobamate in patients with uncontrolled focal seizures: Open‐label extension of a randomized clinical study	35
An interview with Margherita Contento, 2022 Epilepsia Prize winner for clinical research	35
Issue Information	34
Seizure characteristics and outcomes in patients with neurological conditions related to high‐risk paraneoplastic antibodies	34

Author Index	34
Patients carrying pathogenic SCN8A variants with loss‐ and gain‐of‐function effects can be classified into five subgroups exhibiting varying developmental and epileptic components of	33
Risk of vigabatrin‐associated brain abnormalities on MRI: A retrospective and controlled study	33
Climate change: Attitudes and concerns of, and learnings from, people with neurological conditions, carers, and health care professionals	33
Antiseizure medication and perceived “fair” cost allocation: A factorial survey among neurologists, persons with epilepsy, their relatives, and a control group	33
Correction to “Health care utilization of Hispanic/Latino veterans with epilepsy: A national population‐based study”	32
Rapid eye movement sleep affects interictal epileptic activity differently in mesiotemporal and neocortical areas	32
Efficacy, tolerability, and retention of fenfluramine for the treatment of seizures in patients with Dravet syndrome: Compassionate use program in Germany	32
Prognostic scores in status epilepticus: A systematic review and meta‐analysis	32
Modification of brain conductivity in human focal epilepsy: A model‐based estimation from stereoelectroencephalography	32
Heterozygous GABAA receptor β3 subunit N110D knock‐in mice have epileptic spasms	31
Leveraging expertise and optimizing clinical research: Initial success of a pediatric epilepsy surgery collaborative	31
Combined electrophysiological and morphological phenotypes in patients with genetic generalized epilepsy and their healthy siblings	31
Reproduction and genetic causal attribution of epilepsy	30
Using magnetic resonance fingerprinting to characterize periventricular nodular heterotopias in pharmacoresistant epilepsy	30
Cenobamate efficacy in specific populations	30
Fully automated detection of focal cortical dysplasia: Comparison of MPRAGE and MP2RAGE sequences	30
Excess health care use is significantly and persistently reduced following diagnosis of late‐onset epilepsy	30
Issue Information	30
Efficacy of cannabidiol in convulsive and nonconvulsive seizure types associated with treatment‐resistant epilepsies in the Expanded Access Program	30
Spike patterns surrounding sleep and seizures localize the seizure‐onset zone in focal epilepsy	30
Corrigendum	30
Outcomes of the second withdrawal of anti‐seizure medication in patients with pediatric‐onset epilepsy	30
Carbon emission savings and short‐term health care impacts from telemedicine: An evaluation in epilepsy	30
Quantitative EEG biomarkers for STXBP1‐related disorders	29
Toward personalized machine learning approaches in care of patients with epilepsy	29
Racial/ethnic differences in the association of incident stroke with late onset epilepsy: The Northern Manhattan Study	29
Metabolomic changes in adults with status epilepticus: A human case–control study	29
Primidone improves symptoms in TRPM3‐linked developmental and epileptic encephalopathy with spike‐and‐wave activation in sleep	28
Efficacy and safety of perampanel in patients with seizures associated with Lennox–Gastaut syndrome: A randomized trial	28
Emerging translocator protein–positron emission tomographic imaging improves detection of focal cortical dysplasia	28
Issue Information	28
Can the large language model ChatGPT‐4omni predict outcomes in adult patients with status epilepticus?	28
Long‐term seizure outcomes in patients with hypothalamic hamartoma treated by stereotactic radiofrequency thermocoagulation	27
Glucocorticoid modulation of synaptic plasticity in the human temporal cortex of epilepsy patients: Does chronic stress contribute to memory impairment?	27
Seizure activity triggers tau hyperphosphorylation and amyloidogenic pathways	27
Understanding cardiovascular disease in older adults with epilepsy	26
Epilepsia—October 2023—Announcements	26
Paroxysmal fast activity is a biomarker of treatment response in deep brain stimulation for Lennox–Gastaut syndrome	26
Early alterations of the neuronal network processing whisker‐related sensory signal during absence epileptogenesis	26
High‐mobility group box 1 as a predictive biomarker for drug‐resistant epilepsy: A proof‐of‐concept study	26
An interview with Shruthi Iyer, 2021 Epilepsia Prize Winner for Basic Science Research	26
Response: “What is the risk of unprovoked seizures after acute symptomatic status epilepticus?”	25
Vitamin D prophylaxis in persons with epilepsy?	25
Response: Drug resistance in epilepsy: A reappraisal of the definition is needed	25
Fluoxetine accelerates epileptogenesis and magnifies disease severity in a rat model of acquired epilepsy	25
Long‐term evaluation of anterior thalamic deep brain stimulation for epilepsy in the European MORE registry	25
Issue Information	24
Long‐term treatment with ganaxolone for seizures associated with cyclin‐dependent kinase‐like 5 deficiency disorder: Two‐year open‐label extension follow‐up	24
Latent class analysis of eHealth behaviors among adults with epilepsy	24
Phenotypic heterogeneity in familial epilepsies is influenced by polygenic risk for generalized and focal epilepsies	24
Understanding long‐term changes in patient identity 15–20 years after surgery for temporal lobe epilepsy	24
Epilepsia – October 2021 – Announcements	24
The need for an individualized approach to what is considered a clinically significant reduction in seizure frequency: A patient's perspective	24
Farewell from the Editor‐in‐Chief	24
Creating rare epilepsy cohorts using keyword search in electronic health records	24
Epilepsia – September 2021 – Announcements	24
Attenuation of initial pilocarpine‐induced electrographic seizures by methionine sulfoximine pretreatment tightly correlates with the reduction of extracellular taurine in the hippocampus	24
Epilepsia – January 2025 Announcements	24
Peak width of skeletonized mean diffusivity as a marker of small vessel disease in patients with temporal lobe epilepsy with hippocampal sclerosis	23
Lacosamide decreases neonatal seizures without increasing apoptosis	23
Antiepileptogenic effects of rapamycin in a model of infantile spasms due to structural lesions	23
Amitriptyline use in individuals with KCNQ2/3 gain‐of‐function variants: A retrospective cohort study	23
	23
Incidence and risk factors of posttraumatic epilepsy following pediatric traumatic brain injury: A systematic review and meta‐analysis	23
Machine learning validation through decision tree analysis of the Epidemiology‐Based Mortality Score in Status Epilepticus	23
Correction to “patterns of subregional cerebellar atrophy across epilepsy syndromes: An ENIGMA—Epilepsy study”	23
Predicting posttraumatic epilepsy using admission electroencephalography after severe traumatic brain injury	23
A systematic review and meta‐analysis of ketamine in pediatric status epilepticus	23
Increased uptake of the P2X7 receptor radiotracer 18F‐JNJ‐64413739 in the brain and peripheral organs according to the severity of status epilepticus in male mice	22
The long‐term efficacy of cannabidiol in the treatment of refractory epilepsy	22
Learning to generalize seizure forecasts	22
The “make or break” impact of family dynamics on psychological outcomes in focal epilepsy	22
Gut microbiota modulates seizure susceptibility	22
Limbic and paralimbic respiratory modulation: From inhibition to enhancement	22
Efficacy of neuromodulation of the pulvinar nucleus for drug‐resistant epilepsy	22
Sustained rescue of seizure control in patients with highly refractory chronic epilepsy using empiric immunotherapy	22
Not surgical technique, but etiology, contralateral MRI, prior surgery, and side of surgery determine seizure outcome after pediatric hemispherotomy	22
Elevated photic response is followed by a rapid decay and depressed state in ictogenic networks	21
Evaluation of diazepam nasal spray in patients with epilepsy concomitantly using maintenance benzodiazepines: An interim subgroup analysis from a phase 3, long‐term, open‐label safety study	21

Issue Information	21
A systems medicine strategy to predict the efficacy of drugs for monogenic epilepsies	21
Trends in management of patients with new‐onset refractory status epilepticus (NORSE) from 2016 to 2023: An interim analysis	21
Epileptic heart: A clinical syndromic approach	21
Clinical phenotypic spectrum of NRXN1 microdeletions and their association with epilepsy: A systematic review and meta‐analysis	21
Early life seizures and epileptic spasms in STXBP1‐related disorders	21
Tracing topics and trends in drug‐resistant epilepsy research using a natural language processing–based topic modeling approach	21
Bridged bicyclic compounds: Comprehending a novel compound class as potential anti‐seizure agents	21
Visually or auditorily induced seizures involve the activation of nonhippocampal brain areas and hippocampal removal does not alleviate seizures in a mouse model of temporal lobe epilepsy	21
Epilepsy in cerebral amyloid angiopathy: an observational retrospective study of a large population	20
Semiautomatic interictal electric source localization based on long‐term electroencephalographic monitoring: A prospective study	20
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Drug resistance in epilepsy: A reappraisal of the definition is needed	20
A knowledge synthesis of health research reporting standards relevant to epilepsy surgery	20
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Epilepsia – May 2023 – Announcements	20
Satellite Symposium	20
Revisiting the concept of drug‐resistant epilepsy: A TASK1 report of the ILAE/AES Joint Translational Task Force	20
Issue Information	20
Antiseizure medications in the World Health Organization list of “essential medicines”	20
Enlarged perivascular space in the temporal lobe as a prognostic marker in temporal lobe epilepsy with hippocampal sclerosis	19
Add‐on treatment with cenobamate is already effective at low doses in refractory focal epilepsy: A prospective observational study	19
Integrated care for mental health in epilepsy: A systematic review and meta‐synthesis by the International League Against Epilepsy Integrated Mental Health Care Pathways Task Force	19
Putative roles for homeostatic plasticity in epileptogenesis	19
Unsupervised clustering of a deeply phenotyped cohort of adults with idiopathic generalized epilepsy	19
Analysis of participant race and sex reporting and disparities in US epilepsy clinical trials	19
Clinical seizure semiology is subtle and identification of seizures by parents is unreliable in infants with tuberous sclerosis complex	19
Neurobehavioral deficits and a progressive ictogenesis in the tetrodotoxin model of epileptic spasms	19
Epilepsia – June 2024 Announcements	19
Risk of recurrence in patients with an unprovoked tonic–clonic seizure and generalized epileptiform discharges on EEG	19
Neurological morbidity of surgery for suprasylvian operculoinsular epilepsy	19
Long‐term seizure and psychosocial outcomes of patients with ring chromosome 20 syndrome: A cohort study of 47 cases	19
Telemedicine as a path to bridging inequities in patients with epilepsy	19
Concordance between focal brain temperature elevations and focal edema in temporal lobe epilepsy	19
Status epilepticus suspected autoimmune: Neuronal surface antibodies and main clinical features	19
Community‐based epilepsy care in an onchocerciasis‐endemic area: A 3‐year cohort study in Mahenge, Tanzania	19
Electroencephalographic source imaging of spikes with concurrent high‐frequency oscillations is concordant with the clinical ground truth	18
Distinct peripheral pro‐inflammatory profile associated with tuberous sclerosis complex and epilepsy	18
Brain molecular mechanisms in Rasmussen encephalitis	18
Sudden unexpected death in epilepsy during cenobamate clinical development	18
Noninvasive mobile EEG as a tool for seizure monitoring and management: A systematic review	18
Quantitative analysis of visually reviewed normal scalp EEG predicts seizure freedom following anterior temporal lobectomy	18
Fast activity chirp patterns in focal seizures from patients and animal models	18
Introduction to the epilepsy syndrome papers	18
Detection of focal cortical dysplasia: Development and multicentric evaluation of artificial intelligence models	18
Using nirmatrelvir/ritonavir in patients with epilepsy: An update from the Israeli chapter of the International League Against Epilepsy	18
Practical considerations in epilepsy neurostimulation	18
WONOEP appraisal: Genetic insights into early onset epilepsies	18
Anticonvulsant dopamine type 2 receptor agonist activates inhibitory parvalbumin interneurons	18
Proof of concept: Portable ultra‐low‐field magnetic resonance imaging for the diagnosis of epileptogenic brain pathologies	18
Effect of adenosinergic manipulations on amygdala‐kindled seizures in mice: Implications for sudden unexpected death in epilepsy	18
Plasma neurofilament heavy chain is a prognostic biomarker for the development of severe epilepsy after experimental traumatic brain injury	18
Methodology for classification and definition of epilepsy syndromes with list of syndromes: Report of the ILAE Task Force on Nosology and Definitions	18
Neurophotonic methods in approach to in vivo animal epileptic models: Advantages and limitations	18
Seizures in anti‐Hu–associated extra‐limbic encephalitis: Characterization of a unique disease manifestation	17
Neurodevelopment of babies born to mothers with epilepsy: A prospective observational cohort study	17
Epilepsia – February 2022 – Announcements	17
Insights into familial adult myoclonus epilepsy pathogenesis: How the same repeat expansion in six unrelated genes may lead to cortical excitability	17
Stimulation better targets fast‐ripple generating networks in super responders to the responsive neurostimulator system	17
Epilepsia – September 2023 – Announcements	17
Epilepsia – December 2021 – Announcements	17
A pharmacogenomic assessment of psychiatric adverse drug reactions to levetiracetam	17
Association between pediatric traumatic brain injury and epilepsy at later ages in Finland: A nationwide register‐based cohort study	17
Age‐associated differences in FIRES: Characterizing prodromal presentation and long‐term outcomes via the web‐based NORSE/FIRES Family Registry	17
Differential functional connectivity of amygdala in drug‐resistant temporal lobe epilepsy	17
An interview with Riccardo De Feo, 2023 Epilepsia Prize winner for Basic Science Research	17
Cross‐cultural application of the International Classification of Cognitive Disorders in Epilepsy (IC‐CoDE)	17
Potential role of regulatory DNA variants in modifying the risk of severe cutaneous reactions induced by aromatic anti‐seizure medications	17
Stereo‐EEG–based ictal functional connectivity in patients with periventricular nodular heterotopia–related epilepsy	17
Substantial early changes in bone and calcium metabolism among adult pharmacoresistant epilepsy patients on a modified Atkins diet	17
Seizures and stigmas: Double burden on transgender health	17
Assessing seizure burden in pediatric epilepsy using an electronic medical record–based tool through a common data element approach	17
Exogenous ketones exert antiseizure effects and modulate the gut microbiome and mycobiome in a clinically relevant murine model of epilepsy	17
Issue Information	17
Reappraisal of the Medical Research Council Antiepileptic Drug Withdrawal Study: Contamination‐adjusted and dose‐response re‐analysis	16
Antiepileptic treatment with levetiracetam during the first trimester and pregnancy outcome: An observational study	16
A national study of epilepsy‐related deaths in Scotland: Trends, mechanisms, and avoidable deaths	16
Disrupting the epileptogenic network with stereoelectroencephalography‐guided radiofrequency thermocoagulation	16
Pediatric epilepsy surgery from 2000 to 2018: Changes in referral and surgical volumes, patient characteristics, genetic testing, and postsurgical outcomes	16
Inflammatory and neurotrophic factor plasma levels are related to epilepsy independently of etiology	16
Identification of a new retigabine derivative with improved photostability for selective activation of neuronal Kv7 channels and antiseizure activity	16
Prognostic value of Salzburg nonconvulsive status epilepticus criteria: The SACE score	16
Sustainability of seizure reduction and seizure control with adjunctive cenobamate: Post hoc analysis of a phase 3, open‐label study	16
Seizure detection using wearable sensors and machine learning: Setting a benchmark	16
Utility of 18F‐fluorodeoxyglucose positron emission tomography in presurgical evaluation of patients with epilepsy: A multicenter study	16
Prediction of seizure recurrence risk following discontinuation of antiepileptic drugs	16
Development and validation of machine learning models for prediction of seizure outcome after pediatric epilepsy surgery	16
Satellite Symposia Abstracts	15
Issue Information	15
The cerebellum in epilepsy	15
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Imaging blood–brain barrier dysfunction in drug‐resistant epilepsy: A multi‐center feasibility study	15
Issue Information	15
Predictors of therapeutic response following thalamic neuromodulation for drug‐resistant pediatric epilepsy: A systematic review and individual patient data meta‐analysis	15
Issue Information	15