Epilepsia

Article	Citations
	610
Long‐term neuroplasticity in language networks after anterior temporal lobe resection	603
	314
Excitatory–inhibitory mismatch shapes node recruitment in an epileptic network	237
Erratum	192
Vitamin B status and association with antiseizure medication in pregnant women with epilepsy	188
Thank you to our Reviewers	157
Forty‐hertz sensory entrainment impedes kindling epileptogenesis and reduces amyloid pathology in an Alzheimer disease mouse model	146
Reasons for ineligibility for clinical trials of patients with medication‐resistant epilepsy	117
Response to Singh et al. 2023: It is premature for a unified hypothesis of sudden unexpected death in epilepsy: A great amount of research is still needed to understand the multisystem cascade	113
Comment on: Failure to use new breakthrough treatments for epilepsy	107
Scalp high‐frequency oscillation spatial distribution is consistent over consecutive nights, while rates vary with antiseizure medication changes	100
Screening for depression in patients with epilepsy: What are the benefits for physicians and patients in the real‐life setting	98
Statistical learning in epilepsy: Behavioral and anatomical mechanisms in the human brain	93
Topiramate ban in women of childbearing potential with idiopathic generalized epilepsy: Does effectiveness offset the teratogenic risks?	88
Optimizing pediatric status epilepticus management: The role of early midazolam infusion and adherence to clinical practice guidelines	86
Surgical outcomes and motor function in pediatric peri‐Rolandic epilepsy: A single center's experience with 152 cases	83
Sustained seizure freedom with adjunctive brivaracetam in patients with focal onset seizures	81
Extended follow‐up after anterior temporal lobectomy demonstrates seizure recurrence 20+ years postsurgery	80
The transcriptomic signature of DEPDC5 KO induced mTOR hyperactivation in human neurons and its response to rapamycin treatment	78
Protective effect of CACNA1A deficiency in oligogenic refractory epilepsy with CACNA1A‐CELSR2 digenic mutations	75
Optimizing external validation of deep neural networks for interictal discharge detection	75
Clinical effectiveness, feasibility, acceptability, and usability of mobile health applications for epilepsy: A systematic review	73
PAC‐FOS: A novel translational concordance framework identifies preclinical seizure models with highest predictive validity for clinical focal onset seizures	66
Cytomegalic parvalbumin neurons in fetal cases of hemimegalencephaly	62

Intracerebroventricular administration for delivery of antiseizure therapeutics: Challenges and opportunities	61
SCN8A self‐limited infantile epilepsy: Does epilepsy resolve?	60
Anticonvulsive properties of soticlestat, a novel cholesterol 24‐hydroxylase inhibitor	60
Neurocardiac pathologies associated with potassium channelopathies	57
Evaluating the efficacy of prototype antiseizure drugs using a preclinical pharmacokinetic approach	57
Role of cholesterol in modulating brain hyperexcitability	57
Unmasking the role of the occipital lobe in epilepsy with eyelid myoclonia	57
Decision‐making in stereotactic epilepsy surgery	54
Sleep, oscillations, and epilepsy	53
Prediction of long‐term unprovoked seizures after status epilepticus	50
Hippocampal sclerosis and temporal lobe epilepsy following febrile status epilepticus: The FEBSTAT study	50
Epilepsia – January 2023 – Announcements	48
Issue Information	47
Decreased uncinate fasciculus integrity in functional seizures following traumatic brain injury	46
Verbal fluency functional magnetic resonance imaging detects anti‐seizure effects and affective side effects of perampanel in people with focal epilepsy	45
Altered thalamic connectivity patterns in pediatric temporal lobe epilepsy: A gradient mapping study	44
High‐dose folic acid use and cancer risk in women who have given birth: A register‐based cohort study	43
Scoping review and expert‐based consensus recommendations for assessment and management of psychogenic non‐epileptic (functional) seizures (PNES) in children: A report from the Pediatric Ps	43
Quantifying hubness to predict surgical outcomes in epilepsy: Assessing resection‐hub alignment in interictal intracranial EEG networks	43
Machine learning approaches for imaging‐based prognostication of the outcome of surgery for mesial temporal lobe epilepsy	43
Long‐term individual retention with cenobamate in adults with focal seizures: Pooled data from the clinical development program	42
MEG abnormalities and mechanisms of surgical failure in neocortical epilepsy	42
Altered amygdala volumes and microstructure in focal epilepsy patients with tonic–clonic seizures, ictal, and post‐convulsive central apnea	42
Predictive power of phase 1 studies for the identification of seizure onset zone in phase 2 in a pediatric epilepsy cohort	41
Asymmetry of generalized discharges in idiopathic generalized epilepsy in adults	41
Cerebral vascular and blood brain–barrier abnormalities in a mouse model of epilepsy and tuberous sclerosis complex	41
Increasing challenges to trial recruitment and conduct over time	40
Health‐related quality of life in adults with drug‐resistant focal epilepsy treated with modified Atkins diet in a randomized clinical trial	40
Flexible realistic simulation of seizure occurrence recapitulating statistical properties of seizure diaries	39
Statistical characteristics of large‐scale objective tonic–clonic seizure records from medical smartwatches used in daily life	39
Multicenter, cross‐sectional study of the costs of illness and cost‐driving factors in adult patients with epilepsy	38
Diet composition and sterilization modifies intestinal microbiome diversity and burden of Theiler's virus infection–induced acute seizures	38
Home recording of 3‐Hz spike–wave discharges in adults with absence epilepsy using the wearable Sensor Dot	38
A randomized phase 2b efficacy study in patients with seizure episodes with a predictable pattern using Staccato® alprazolam for rapid seizure termination	37
Phase 1 study of ABI‐009 (nab‐rapamycin) for surgically refractory epilepsy (RaSuRE)	37
Reply to: Optimizing external validation of deep neural networks for interictal discharge detection	36
Epilepsy phenotype and its reproducibility after lateral fluid percussion‐induced traumatic brain injury in rats: Multicenter EpiBioS4Rx study project 1	34
Issue Information	34
On‐scalp magnetoencephalography based on optically pumped magnetometers to investigate temporal lobe epilepsy	34
Association of baseline sleep duration and sleep quality with seizure recurrence in newly treated patients with epilepsy	33
Analysis of practical judgment in older adults with epilepsy: An exploratory, multicenter cohort study	33
Effect of levetiracetam on the gene expression of placental transporters in a murine model	33
The nuances of immunotherapy for NORSE/FIRES	33
Seizure freedom after surgical resection of diffusion‐weighted magnetic resonance imaging abnormalities	33
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Seizure clusters: Practical aspects and clinical strategies to care for patients in the community	32
It is premature for a unified hypothesis of sudden unexpected death in epilepsy: A great amount of research is still needed to understand the multisystem cascade	32
Identification of a mosaic MTOR variant in purified neuronal DNA in a patient with focal cortical dysplasia using a novel depth electrode harvesting technique	32
Genome‐wide decrease in DNA methylation in adults with epilepsy treated with modified ketogenic diet: A prospective study	31
No association between histopathology and neurophysiology in surgical specimens from pediatric focal epilepsy patients	31

Pharmacokinetic variability and use of therapeutic drug monitoring of cannabidiol in patients with refractory epilepsy	31
Adherence patterns in antiseizure medications influencing risk of sudden unexplained death in epilepsy: A data linkage study using dispensed prescriptions	31
Mutations associated with epileptic encephalopathy modify EAAT2 anion channel function	30
Assisted reproduction and the fetal malformation risk associated with antiseizure medication exposure in pregnancy	30
Antiseizure medication and perceived “fair” cost allocation: A factorial survey among neurologists, persons with epilepsy, their relatives, and a control group	30
Cognitive phenotypes in frontal lobe epilepsy	30
Clinical adult outcome 11–30 years after pediatric epilepsy surgery: Complications and other surgical adverse events, seizure control, and cure of epilepsy	30
Author Index	30
Perampanel as precision therapy in rare genetic epilepsies	30
Feasibility of and patient satisfaction with Readiness Brain Operation Optimization Training, a manualized cognitive prehabilitation program for epilepsy surgery	30
Development of a preclinical testing platform for clinically relevant therapy for Dravet syndrome	30
Toward personalized machine learning approaches in care of patients with epilepsy	29
Modification of brain conductivity in human focal epilepsy: A model‐based estimation from stereoelectroencephalography	29
An interview with Margherita Contento, 2022 Epilepsia Prize winner for clinical research	29
Climate change: Attitudes and concerns of, and learnings from, people with neurological conditions, carers, and health care professionals	29
Glucocorticoid modulation of synaptic plasticity in the human temporal cortex of epilepsy patients: Does chronic stress contribute to memory impairment?	29
Splicing variants in DEPDC5‐related epilepsies: From functional characterization to correction	28
Can biomarkers of the epileptogenic zone be characterized in patients rendered seizure‐free alone?	28
Evaluation of limbic microstructural abnormalities in temporal lobe epilepsy: A neurite orientation distribution and density imaging study	28
Extracting epilepsy‐related information from unstructured clinic letters using large language models	28
Outcomes of the second withdrawal of anti‐seizure medication in patients with pediatric‐onset epilepsy	28
Corrigendum	27
Seizure monitoring by combined diary and wearable data: A multicenter, longitudinal, observational study	27
Cenobamate efficacy in specific populations	27
Metabolomic changes in adults with status epilepticus: A human case–control study	27
Racial/ethnic differences in the association of incident stroke with late onset epilepsy: The Northern Manhattan Study	27
Epilepsy expands the phenotype of L‐arginine:glycine amidinotransferase deficiency	27
Issue Information	27
Issue Information	27
Differential outcomes in familial and sporadic SCN8A self‐limited infantile epilepsies: Insights from a large international registry	26
Heterozygous GABAA receptor β3 subunit N110D knock‐in mice have epileptic spasms	26
Combined electrophysiological and morphological phenotypes in patients with genetic generalized epilepsy and their healthy siblings	26
Long‐read sequencing of recurrent FGF12 duplications in epilepsy: Insights into structural mechanisms and aberrant isoforms	26
Spike patterns surrounding sleep and seizures localize the seizure‐onset zone in focal epilepsy	26
Correction to “Health care utilization of Hispanic/Latino veterans with epilepsy: A national population‐based study”	26
Paroxysmal fast activity is a biomarker of treatment response in deep brain stimulation for Lennox–Gastaut syndrome	26
Patients carrying pathogenic SCN8A variants with loss‐ and gain‐of‐function effects can be classified into five subgroups exhibiting varying developmental and epileptic components of	26
Rapid eye movement sleep affects interictal epileptic activity differently in mesiotemporal and neocortical areas	26
Fully automated detection of focal cortical dysplasia: Comparison of MPRAGE and MP2RAGE sequences	26
Excess health care use is significantly and persistently reduced following diagnosis of late‐onset epilepsy	26
Efficacy and safety of perampanel in patients with seizures associated with Lennox–Gastaut syndrome: A randomized trial	26
Emerging translocator protein–positron emission tomographic imaging improves detection of focal cortical dysplasia	26
Can the large language model ChatGPT‐4omni predict outcomes in adult patients with status epilepticus?	26
Risk of vigabatrin‐associated brain abnormalities on MRI: A retrospective and controlled study	25
Primidone improves symptoms in TRPM3‐linked developmental and epileptic encephalopathy with spike‐and‐wave activation in sleep	25
Seizure characteristics and outcomes in patients with neurological conditions related to high‐risk paraneoplastic antibodies	25
Quantitative EEG biomarkers for STXBP1‐related disorders	25
Long‐term seizure outcomes in patients with hypothalamic hamartoma treated by stereotactic radiofrequency thermocoagulation	25
Efficacy of cannabidiol in convulsive and nonconvulsive seizure types associated with treatment‐resistant epilepsies in the Expanded Access Program	25
Reliability and diagnostic accuracy of home video recording in differentiating sleep‐related hypermotor epilepsy from disorders of arousal	24
Seizure activity triggers tau hyperphosphorylation and amyloidogenic pathways	24
Epilepsia—October 2023—Announcements	24
Leveraging expertise and optimizing clinical research: Initial success of a pediatric epilepsy surgery collaborative	24
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Epilepsia – October 2021 – Announcements	24
Prognostic scores in status epilepticus: A systematic review and meta‐analysis	24
Using magnetic resonance fingerprinting to characterize periventricular nodular heterotopias in pharmacoresistant epilepsy	24
High‐mobility group box 1 as a predictive biomarker for drug‐resistant epilepsy: A proof‐of‐concept study	24
Reproduction and genetic causal attribution of epilepsy	24
Issue Information	23
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Learning to generalize seizure forecasts	23
Epilepsia – January 2025 Announcements	23
Machine learning validation through decision tree analysis of the Epidemiology‐Based Mortality Score in Status Epilepticus	23
Correction to “patterns of subregional cerebellar atrophy across epilepsy syndromes: An ENIGMA—Epilepsy study”	23
Peak width of skeletonized mean diffusivity as a marker of small vessel disease in patients with temporal lobe epilepsy with hippocampal sclerosis	23
Latent class analysis of eHealth behaviors among adults with epilepsy	22
Farewell from the Editor‐in‐Chief	22
Amitriptyline use in individuals with KCNQ2/3 gain‐of‐function variants: A retrospective cohort study	22
Creating rare epilepsy cohorts using keyword search in electronic health records	21
Efficacy of neuromodulation of the pulvinar nucleus for drug‐resistant epilepsy	21
Early life seizures and epileptic spasms in STXBP1‐related disorders	21
Vitamin D prophylaxis in persons with epilepsy?	21
Response: “What is the risk of unprovoked seizures after acute symptomatic status epilepticus?”	21
The need for an individualized approach to what is considered a clinically significant reduction in seizure frequency: A patient's perspective	21
Response: Drug resistance in epilepsy: A reappraisal of the definition is needed	21
Attenuation of initial pilocarpine‐induced electrographic seizures by methionine sulfoximine pretreatment tightly correlates with the reduction of extracellular taurine in the hippocampus	21
Fluoxetine accelerates epileptogenesis and magnifies disease severity in a rat model of acquired epilepsy	21
Clioquinol as a new therapy in epilepsy: From preclinical evidence to a proof‐of‐concept clinical study	21
Early seizure freedom with [18F]fluorodopa positron emission tomography response after isocitrate dehydrogenase inhibition with vorasidenib: First case report	20

Mesial‐to‐lateral gradients of epileptiform activity to localize mesial temporal lobe epilepsy	20
Long‐term treatment with ganaxolone for seizures associated with cyclin‐dependent kinase‐like 5 deficiency disorder: Two‐year open‐label extension follow‐up	20
Not surgical technique, but etiology, contralateral MRI, prior surgery, and side of surgery determine seizure outcome after pediatric hemispherotomy	20
The “make or break” impact of family dynamics on psychological outcomes in focal epilepsy	20
Predicting posttraumatic epilepsy using admission electroencephalography after severe traumatic brain injury	20
Trends in management of patients with new‐onset refractory status epilepticus (NORSE) from 2016 to 2023: An interim analysis	20
Comparison of children and adults undergoing subdural grid electrode implantation or stereoelectroencephalography in a refractory epilepsy cohort from four European centers	20
Sustained rescue of seizure control in patients with highly refractory chronic epilepsy using empiric immunotherapy	20
Incidence and risk factors of posttraumatic epilepsy following pediatric traumatic brain injury: A systematic review and meta‐analysis	20
Increased uptake of the P2X7 receptor radiotracer 18F‐JNJ‐64413739 in the brain and peripheral organs according to the severity of status epilepticus in male mice	20
Role of vitamin D supplementation and vitamin D receptor in drug‐resistant epilepsy: A double‐blind placebo‐controlled trial conducted in India	20
Phenotypic heterogeneity in familial epilepsies is influenced by polygenic risk for generalized and focal epilepsies	20
Long‐term evaluation of anterior thalamic deep brain stimulation for epilepsy in the European MORE registry	20
A systematic review and meta‐analysis of ketamine in pediatric status epilepticus	20
Early alterations of the neuronal network processing whisker‐related sensory signal during absence epileptogenesis	19
Issue Information	19
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Epilepsia – May 2023 – Announcements	19
Elevated photic response is followed by a rapid decay and depressed state in ictogenic networks	19
Limbic and paralimbic respiratory modulation: From inhibition to enhancement	19
Issue Information	19
Neurophotonic methods in approach to in vivo animal epileptic models: Advantages and limitations	19
Tracing topics and trends in drug‐resistant epilepsy research using a natural language processing–based topic modeling approach	19
Lacosamide decreases neonatal seizures without increasing apoptosis	19
Satellite Symposium	19
Effect of adenosinergic manipulations on amygdala‐kindled seizures in mice: Implications for sudden unexpected death in epilepsy	19
Analysis of participant race and sex reporting and disparities in US epilepsy clinical trials	18
Plasma neurofilament heavy chain is a prognostic biomarker for the development of severe epilepsy after experimental traumatic brain injury	18
Proof of concept: Portable ultra‐low‐field magnetic resonance imaging for the diagnosis of epileptogenic brain pathologies	18
Quantitative analysis of visually reviewed normal scalp EEG predicts seizure freedom following anterior temporal lobectomy	18
Practical considerations in epilepsy neurostimulation	18
Telemedicine as a path to bridging inequities in patients with epilepsy	18
Clinical seizure semiology is subtle and identification of seizures by parents is unreliable in infants with tuberous sclerosis complex	18
Epilepsia – June 2024 Announcements	18
Peripheral blood mononuclear cell secretome from patients with autoimmune encephalitis promotes seizures in vitro	18
Semiautomatic interictal electric source localization based on long‐term electroencephalographic monitoring: A prospective study	18
Unsupervised clustering of a deeply phenotyped cohort of adults with idiopathic generalized epilepsy	18
Neurobehavioral deficits and a progressive ictogenesis in the tetrodotoxin model of epileptic spasms	18
Sudden unexpected death in epilepsy during cenobamate clinical development	18
Add‐on treatment with cenobamate is already effective at low doses in refractory focal epilepsy: A prospective observational study	18
Epilepsy in cerebral amyloid angiopathy: an observational retrospective study of a large population	18
Distinct peripheral pro‐inflammatory profile associated with tuberous sclerosis complex and epilepsy	17
Using nirmatrelvir/ritonavir in patients with epilepsy: An update from the Israeli chapter of the International League Against Epilepsy	17
Detection of focal cortical dysplasia: Development and multicentric evaluation of artificial intelligence models	17
Putative roles for homeostatic plasticity in epileptogenesis	17
Integrated care for mental health in epilepsy: A systematic review and meta‐synthesis by the International League Against Epilepsy Integrated Mental Health Care Pathways Task Force	17
Antiseizure medications in the World Health Organization list of “essential medicines”	17
Revisiting the concept of drug‐resistant epilepsy: A TASK1 report of the ILAE/AES Joint Translational Task Force	17
Risk of recurrence in patients with an unprovoked tonic–clonic seizure and generalized epileptiform discharges on EEG	17
A systems medicine strategy to predict the efficacy of drugs for monogenic epilepsies	17
Brain molecular mechanisms in Rasmussen encephalitis	17
Community‐based epilepsy care in an onchocerciasis‐endemic area: A 3‐year cohort study in Mahenge, Tanzania	17
Bridged bicyclic compounds: Comprehending a novel compound class as potential anti‐seizure agents	17
A knowledge synthesis of health research reporting standards relevant to epilepsy surgery	17
Drug resistance in epilepsy: A reappraisal of the definition is needed	17
Electroencephalographic source imaging of spikes with concurrent high‐frequency oscillations is concordant with the clinical ground truth	17
Visually or auditorily induced seizures involve the activation of nonhippocampal brain areas and hippocampal removal does not alleviate seizures in a mouse model of temporal lobe epilepsy	17
Neurological morbidity of surgery for suprasylvian operculoinsular epilepsy	17
How often do caregivers attend their child when a seizure detection device alerts for a nocturnal major motor seizure?	16
Introduction to the epilepsy syndrome papers	16
Epilepsia – December 2021 – Announcements	16
Age‐associated differences in FIRES: Characterizing prodromal presentation and long‐term outcomes via the web‐based NORSE/FIRES Family Registry	16
Epilepsia – February 2022 – Announcements	16
Enlarged perivascular space in the temporal lobe as a prognostic marker in temporal lobe epilepsy with hippocampal sclerosis	16
Concordance between focal brain temperature elevations and focal edema in temporal lobe epilepsy	16
Evaluating crowdsourcing for ICU EEG annotation: A comparison with expert performance	16
Epilepsia – September 2023 – Announcements	16
Seizure outcomes after resection of temporal encephalocele in patients with drug‐resistant epilepsy: A systematic review and meta‐analysis	16
Topographical map of subjective states evoked by focal seizures and electrical stimulation of the human insula	16
Fast activity chirp patterns in focal seizures from patients and animal models	16
Clinical phenotypic spectrum of NRXN1 microdeletions and their association with epilepsy: A systematic review and meta‐analysis	16
Long‐term seizure and psychosocial outcomes of patients with ring chromosome 20 syndrome: A cohort study of 47 cases	16
Issue Information	16
Seizures in anti‐Hu–associated extra‐limbic encephalitis: Characterization of a unique disease manifestation	16
Electroconvulsive therapy for super refractory status epilepticus: A scoping review	16
Methodology for classification and definition of epilepsy syndromes with list of syndromes: Report of the ILAE Task Force on Nosology and Definitions	16
Noninvasive mobile EEG as a tool for seizure monitoring and management: A systematic review	16
Exogenous ketones exert antiseizure effects and modulate the gut microbiome and mycobiome in a clinically relevant murine model of epilepsy	15
Sustainability of seizure reduction and seizure control with adjunctive cenobamate: Post hoc analysis of a phase 3, open‐label study	15
WONOEP appraisal: Genetic insights into early onset epilepsies	15
Automated detection of interictal epileptiform discharges with few electroencephalographic channels	15
Reappraisal of the Medical Research Council Antiepileptic Drug Withdrawal Study: Contamination‐adjusted and dose‐response re‐analysis	15
Insights into familial adult myoclonus epilepsy pathogenesis: How the same repeat expansion in six unrelated genes may lead to cortical excitability	15
Pharmacokinetics and 180‐day safety of diazepam nasal spray in pediatric patients with epilepsy aged 2–5 years	15
Seizure‐onset zone lateralization in temporal lobe epilepsy using 7T rs‐fMRI: Direct comparison with 3T rs‐fMRI	15
Cross‐cultural application of the International Classification of Cognitive Disorders in Epilepsy (IC‐CoDE)	15
A national study of epilepsy‐related deaths in Scotland: Trends, mechanisms, and avoidable deaths	15
Long‐term intellectual and developmental outcomes after pediatric epilepsy surgery: A systematic review and meta‐analysis	15
Evidence supporting deep brain stimulation of the medial septum in the treatment of temporal lobe epilepsy	15
Stimulation better targets fast‐ripple generating networks in super responders to the responsive neurostimulator system	15
Antiepileptic treatment with levetiracetam during the first trimester and pregnancy outcome: An observational study	15
Prognostic value of Salzburg nonconvulsive status epilepticus criteria: The SACE score	15
Differential functional connectivity of amygdala in drug‐resistant temporal lobe epilepsy	15
Incidence of sudden unexpected death in epilepsy in New Zealand: A prospective population‐wide, 2‐year study	15