Epilepsia

Article	Citations
	818
Extreme cryptogenic new onset refractory status epilepticus/febrile infection‐related epilepsy syndrome: Evidence of profound neuroinflammation and neuronal injury	775
Preclinical signal for a disease‐modifying effect on seizure cluster severity with intermittent diazepam treatment	398
Optimizing pediatric status epilepticus management: The role of early midazolam infusion and adherence to clinical practice guidelines	321
Reasons for ineligibility for clinical trials of patients with medication‐resistant epilepsy	247
Role of cholesterol in modulating brain hyperexcitability	245
Evaluating the efficacy of prototype antiseizure drugs using a preclinical pharmacokinetic approach	236
Neurocardiac pathologies associated with potassium channelopathies	213
Comment on: Failure to use new breakthrough treatments for epilepsy	147
The transcriptomic signature of DEPDC5 KO induced mTOR hyperactivation in human neurons and its re	144
Unmasking the role of the occipital lobe in epilepsy with eyelid myoclonia	129
Fast cycle of vagus nerve stimulation is associated with increased sleep‐related breathing disorder in patients with epilepsy	123
Statistical learning in epilepsy: Behavioral and anatomical mechanisms in the human brain	119
Author index	116
Protective effect of CACNA1A deficiency in oligogenic refractory epilepsy with CACNA1A‐CELSR2 digenic mutations	105
Optimizing external validation of deep neural networks for interictal discharge detection	81
Cytomegalic parvalbumin neurons in fetal cases of hemimegalencephaly	80
Excitatory–inhibitory mismatch shapes node recruitment in an epileptic network	77
Decision‐making in stereotactic epilepsy surgery	76
PAC ‐ FOS: A novel translational concordance framework identifies preclinical seizure models with highest predictive v	70
Topiramate ban in women of childbearing potential with idiopathic generalized epilepsy: Does effectiveness offset the teratogenic risks?	63
Scalp high‐frequency oscillation spatial distribution is consistent over consecutive nights, while rates vary with antiseizure medication changes	62
Tissue oxygenation dynamics during transition from seizure to spreading depolarization in rat brain	61
Long‐term neuroplasticity in language networks after anterior temporal lobe resection	61
Cognitive stagnation and executive function deficits in young children with SCN1A + Dravet syndrom	58

Surgical outcomes and motor function in pediatric peri‐Rolandic epilepsy: A single center's experience with 152 cases	56
Sleep, oscillations, and epilepsy	55
Artificial intelligence for adaptive neuromodulation in drug‐resistant epilepsy	53
Response to Singh et al. 2023: It is premature for a unified hypothesis of sudden unexpected death in epilepsy: A great amount of research is still needed to understand the multisystem cascade	52
Targeting interictal low‐entropy zones during epilepsy surgery predicts successful outcomes in pediatric drug‐resistant epilepsy	50
Seizure outcomes in persons with autism spectrum disorder undergoing epilepsy surgery: A systematic review and meta‐analysis	50
Response: Reconsidering nonconvulsive status epilepticus diagnosis: 2.5‐Hz or etiology‐driven frequency cutoffs?	49
Impact of epilepsy on people experiencing homelessness: A mixed‐methods study	49
SCN8A self‐limited infantile epilepsy: Does epilepsy resolve?	48
Delayed excitability recovery and downregulation of neurodevelopmental pathways contribute to phenotypic differences in KCNQ2	48
Extended follow‐up after anterior temporal lobectomy demonstrates seizure recurrence 20+ years postsurgery	48
Prediction of long‐term unprovoked seizures after status epilepticus	46
Hippocampal sclerosis and temporal lobe epilepsy following febrile status epilepticus: The FEBSTAT study	45
Validation of the International League Against Epilepsy ( ILAE ) Risk of Bias Tool against the Newcastle–Ottawa Scale in epilepsy research	45
Olig2‐specific loss‐of‐function Slc35a2 results in hypomyelination and spontaneous seizures	45
Forty‐hertz sensory entrainment impedes kindling epileptogenesis and reduces amyloid pathology in an Alzheimer disease mouse model	45
Epilepsy treatment over time: The chess game analogy for choosing, adjusting, and adding antiseizure medications	45
Intracerebroventricular administration for delivery of antiseizure therapeutics: Challenges and opportunities	43
Clinical effectiveness, feasibility, acceptability, and usability of mobile health applications for epilepsy: A systematic review	43
Screening for depression in patients with epilepsy: What are the benefits for physicians and patients in the real‐life setting	42
The nuances of immunotherapy for NORSE/FIRES	41
Epilepsia – January 2023 – Announcements	41
Asymmetry of generalized discharges in idiopathic generalized epilepsy in adults	40
Verbal fluency functional magnetic resonance imaging detects anti‐seizure effects and affective side effects of perampanel in people with focal epilepsy	40
Did the French pregnancy pictogram change antiseizure medication use during pregnancy?	40
Genome‐wide decrease in DNA methylation in adults with epilepsy treated with modified ketogenic diet: A prospective study	39
Issue Information	39
No association between histopathology and neurophysiology in surgical specimens from pediatric focal epilepsy patients	39
Underutilization of syndrome‐specific ICD ‐10 codes for genetic epilepsies: Implications for precision medicine	38
Association of baseline sleep duration and sleep quality with seizure recurrence in newly treated patients with epilepsy	38
Altered amygdala volumes and microstructure in focal epilepsy patients with tonic–clonic seizures, ictal, and post‐convulsive central apnea	38
Diet composition and sterilization modifies intestinal microbiome diversity and burden of Theiler's virus infection–induced acute seizures	37
Health‐related quality of life in adults with drug‐resistant focal epilepsy treated with modified Atkins diet in a randomized clinical trial	37
Reply to: Optimizing external validation of deep neural networks for interictal discharge detection	37
Pharmacokinetic variability and use of therapeutic drug monitoring of cannabidiol in patients with refractory epilepsy	37
Paroxysmal slow wave events as a diagnostic biomarker for epilepsy: Lessons from rural Zambia	36
Issue Information	36
Phase 1 study of ABI ‐009 ( nab ‐rapamycin) for surgically refractory epilepsy ( <	36
It is premature for a unified hypothesis of sudden unexpected death in epilepsy: A great amount of research is still needed to understand the multisystem cascade	36
Dissociation in functional/dissociative seizures: Alignment with neurobiology across the lifespan	35
Cognitive phenotypes in frontal lobe epilepsy	35
Development of a preclinical testing platform for clinically relevant therapy for Dravet syndrome	35
High‐dose folic acid use and cancer risk in women who have given birth: A register‐based cohort study	35
On‐scalp magnetoencephalography based on optically pumped magnetometers to investigate temporal lobe epilepsy	34
Optimal approach to standardized documentation in epilepsy clinics: A scoping review	34
Seizure clusters: Practical aspects and clinical strategies to care for patients in the community	34
Integrated genotype–phenotype function analysis reveals distinct pathogenic mechanisms for cognitive impairment in KCNQ2	33
Predictive power of phase 1 studies for the identification of seizure onset zone in phase 2 in a pediatric epilepsy cohort	33
Analysis of practical judgment in older adults with epilepsy: An exploratory, multicenter cohort study	32
Epilepsy phenotype and its reproducibility after lateral fluid percussion‐induced traumatic brain injury in rats: Multicenter EpiBioS4Rx study project 1	32

Home recording of 3‐Hz spike–wave discharges in adults with absence epilepsy using the wearable Sensor Dot	32
Assisted reproduction and the fetal malformation risk associated with antiseizure medication exposure in pregnancy	32
Adherence patterns in antiseizure medications influencing risk of sudden unexplained death in epilepsy: A data linkage study using dispensed prescriptions	32
Decreased uncinate fasciculus integrity in functional seizures following traumatic brain injury	32
Seizure freedom after surgical resection of diffusion‐weighted magnetic resonance imaging abnormalities	32
Clinical adult outcome 11–30 years after pediatric epilepsy surgery: Complications and other surgical adverse events, seizure control, and cure of epilepsy	32
Ablation of cerebellar Purkinje cells enhances seizure susceptibility and promotes kindling	31
Statistical characteristics of large‐scale objective tonic–clonic seizure records from medical smartwatches used in daily life	31
Spindle density relates to cognitive outcomes in infantile epileptic spasms syndrome with unknown etiology: A retrospective cohort study	31
Flexible realistic simulation of seizure occurrence recapitulating statistical properties of seizure diaries	31
MEG abnormalities and mechanisms of surgical failure in neocortical epilepsy	31
A randomized phase 2b efficacy study in patients with seizure episodes with a predictable pattern using Staccato® alprazolam for rapid seizure termination	31
Altered thalamic connectivity patterns in pediatric temporal lobe epilepsy: A gradient mapping study	30
Feasibility of and patient satisfaction with Readiness Brain Operation Optimization Training, a manualized cognitive prehabilitation program for epilepsy surgery	30
Perampanel as precision therapy in rare genetic epilepsies	30
Quantifying hubness to predict surgical outcomes in epilepsy: Assessing resection‐hub alignment in interictal intracranial EEG networks	30
Cerebral vascular and blood brain–barrier abnormalities in a mouse model of epilepsy and tuberous sclerosis complex	29
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Pseudoaneurysms as a complication of stereoelectroencephalography: Case series and clinical recommendations	29
Identification of a mosaic MTOR variant in purified neuronal DNA in a patient with focal cortical dysp	29
Increasing challenges to trial recruitment and conduct over time	28
Scoping review and expert‐based consensus recommendations for assessment and management of psychogenic non‐epileptic (functional) seizures (PNES) in children: A report from the Pediatric Ps	28
Author Index	27
Issue Information	27
Seizure monitoring by combined diary and wearable data: A multicenter, longitudinal, observational study	27
Leveraging expertise and optimizing clinical research: Initial success of a pediatric epilepsy surgery collaborative	27
Issue Information	27
Heterozygous GABAA receptor β3 subunit N110D knock‐in mice have epileptic spasms	27
A phase 3, randomized clinical trial of soticlestat as adjunctive therapy for Lennox–Gastaut syndrome	27
Reproduction and genetic causal attribution of epilepsy	27
Antiseizure medication and perceived “fair” cost allocation: A factorial survey among neurologists, persons with epilepsy, their relatives, and a control group	27
Excess health care use is significantly and persistently reduced following diagnosis of late‐onset epilepsy	27
Can biomarkers of the epileptogenic zone be characterized in patients rendered seizure‐free alone?	27
Cardiac remodeling and arrhythmia in a mouse model of Depdc5 haploinsufficiency	27
Cenobamate efficacy in specific populations	26
Correction to “Health care utilization of Hispanic/Latino veterans with epilepsy: A national population‐based study”	26
Quantitative EEG biomarkers for STXBP1‐related disorders	26
Epilepsy expands the phenotype of L‐arginine:glycine amidinotransferase deficiency	26
Racial/ethnic differences in the association of incident stroke with late onset epilepsy: The Northern Manhattan Study	26
Corrigendum	26
Clinician knowledge gaps in epilepsy surgery: An international survey across 18 countries or regions in Asia–Oceania	26
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Modification of brain conductivity in human focal epilepsy: A model‐based estimation from stereoelectroencephalography	25
Efficacy and safety of perampanel in patients with seizures associated with Lennox–Gastaut syndrome: A randomized trial	25
Splicing variants in DEPDC5 ‐related epilepsies: From functional characterization to correction	25
Thalamic connectivity mirrors spatial maps of network dysfunction in nonlesional focal epilepsy	25
Seizure characteristics and outcomes in patients with neurological conditions related to high‐risk paraneoplastic antibodies	25
Paroxysmal fast activity is a biomarker of treatment response in deep brain stimulation for Lennox–Gastaut syndrome	25
Reliability and diagnostic accuracy of home video recording in differentiating sleep‐related hypermotor epilepsy from disorders of arousal	25
Differential outcomes in familial and sporadic SCN8A self‐limited infantile epilepsies: Insights from a large international registry	25
Genetic testing for familial epilepsies: Diagnostic yield and genetic findings	24
Rapid eye movement sleep affects interictal epileptic activity differently in mesiotemporal and neocortical areas	24
Emerging translocator protein–positron emission tomographic imaging improves detection of focal cortical dysplasia	24
Spike patterns surrounding sleep and seizures localize the seizure‐onset zone in focal epilepsy	24
Potassium–chloride cotransporter 2 activity dampens induced ictal‐like activity in neocortical slices containing the seizure propagation zone of temporal lobe epilepsy patients	24
Evolution of the European Medicines Agency clinical guidelines for epilepsy drug development between 2010 and 2025: A comparative analysis by the ILAE	24
Climate change: Attitudes and concerns of, and learnings from, people with neurological conditions, carers, and health care professionals	24
Can the large language model ChatGPT ‐4omni predict outcomes in adult patients with status epilepticus?	24
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Outcomes of the second withdrawal of anti‐seizure medication in patients with pediatric‐onset epilepsy	24
Surfaced‐based detection of focal cortical dysplasia using magnetic resonance fingerprinting and machine learning	24
Issue Information	24
Evaluation of limbic microstructural abnormalities in temporal lobe epilepsy: A neurite orientation distribution and density imaging study	24
Early response rates with adjunctive cenobamate in uncontrolled focal seizures: Prospective analysis of a randomized, double‐blind, placebo‐controlled study in a multinational Asian population	23
Efficacy of cannabidiol in convulsive and nonconvulsive seizure types associated with treatment‐resistant epilepsies in the Expanded Access Program	23
Metabolomic changes in adults with status epilepticus: A human case–control study	23
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Zebrafish models of developmental epileptic encephalopathy accurately reflect clinical electrographic biomarkers	23
Primidone improves symptoms in TRPM3‐linked developmental and epileptic encephalopathy with spike‐and‐wave activation in sleep	23
Epilepsia—October 2023—Announcements	23
Long‐read sequencing of recurrent FGF12 duplications in epilepsy: Insights into structural mechanisms and aberrant isoforms	23
Extracting epilepsy‐related information from unstructured clinic letters using large language models	23
Prognostic scores in status epilepticus: A systematic review and meta‐analysis	23
Patients carrying pathogenic SCN8A variants with loss‐ and gain‐of‐function effects can be classified into five subgroups exhibiting varying developmental and epileptic components of	23
Epilepsia – January 2025 Announcements	23
Lacosamide decreases neonatal seizures without increasing apoptosis	22
Creating rare epilepsy cohorts using keyword search in electronic health records	22
Response: “What is the risk of unprovoked seizures after acute symptomatic status epilepticus?”	22
Trends in management of patients with new‐onset refractory status epilepticus (NORSE) from 2016 to 2023: An interim analysis	22
The “make or break” impact of family dynamics on psychological outcomes in focal epilepsy	22

Farewell from the Editor‐in‐Chief	22
Attenuation of initial pilocarpine‐induced electrographic seizures by methionine sulfoximine pretreatment tightly correlates with the reduction of extracellular taurine in the hippocampus	22
Correction to “patterns of subregional cerebellar atrophy across epilepsy syndromes: An ENIGMA—Epilepsy study”	22
Issue Information	22
Latent class analysis of eHealth behaviors among adults with epilepsy	22
Response: Drug resistance in epilepsy: A reappraisal of the definition is needed	22
Machine learning validation through decision tree analysis of the Epidemiology‐Based Mortality Score in Status Epilepticus	22
Phenotypic heterogeneity in familial epilepsies is influenced by polygenic risk for generalized and focal epilepsies	21
Amitriptyline use in individuals with KCNQ2/3 gain‐of‐function variants: A retrospective cohort study	21
Deep characterization of refractory epilepsy due to mild malformation of cortical development with oligodendroglial hyperplasia ( MOGHE ) and insight	21
Epilepsia – January 2026 Announcements	21
Incidence and risk factors of posttraumatic epilepsy following pediatric traumatic brain injury: A systematic review and meta‐analysis	21
Vitamin D prophylaxis in persons with epilepsy?	21
Limbic and paralimbic respiratory modulation: From inhibition to enhancement	21
Haploinsufficiency of brain‐specific kinase BRSK1 causes epilepsy and neurodevelopmental disorders	21
Not surgical technique, but etiology, contralateral MRI, prior surgery, and side of surgery determine seizure outcome after pediatric hemispherotomy	21
Tracing topics and trends in drug‐resistant epilepsy research using a natural language processing–based topic modeling approach	21
Mesial‐to‐lateral gradients of epileptiform activity to localize mesial temporal lobe epilepsy	21
Predicting posttraumatic epilepsy using admission electroencephalography after severe traumatic brain injury	21
Increased uptake of the P2X7 receptor radiotracer 18F‐JNJ‐64413739 in the brain and peripheral organs according to the severity of status epilepticus in male mice	20
Quantifying the impact of a computer‐aided diagnostic score on the clinical diagnosis of functional seizures	20
Role of vitamin D supplementation and vitamin D receptor in drug‐resistant epilepsy: A double‐blind placebo‐controlled trial conducted in India	20
Long‐term treatment with ganaxolone for seizures associated with cyclin‐dependent kinase‐like 5 deficiency disorder: Two‐year open‐label extension follow‐up	20
Comparison of children and adults undergoing subdural grid electrode implantation or stereoelectroencephalography in a refractory epilepsy cohort from four European centers	20
The need for an individualized approach to what is considered a clinically significant reduction in seizure frequency: A patient's perspective	20
Clioquinol as a new therapy in epilepsy: From preclinical evidence to a proof‐of‐concept clinical study	20
A systematic review and meta‐analysis of ketamine in pediatric status epilepticus	20
Hippocampal atrophy and functional plasticity underlie cognitive outcome in anti‐leucine‐rich glioma‐inactivated protein 1 encephalitis and their clinical correlates	20
Value of ultra‐high‐field MRI in patients with drug‐resistant focal epilepsy and negative 3T MRI (	20
Learning to generalize seizure forecasts	20
Peak width of skeletonized mean diffusivity as a marker of small vessel disease in patients with temporal lobe epilepsy with hippocampal sclerosis	20
Applicability and feasibility of the updated ILAE seizure classification in secondary referral centers	19
Early seizure freedom with [ 18 F ]fluorodopa positron emission tomograp	19
Elevated photic response is followed by a rapid decay and depressed state in ictogenic networks	19
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Issue Information	19
Satellite Symposium	19
A novel PTEN variant causing hemimegalencephaly and focal nodular heterotopias in the developing h	19
Long‐term evaluation of anterior thalamic deep brain stimulation for epilepsy in the European MORE registry	19
Early life seizures and epileptic spasms in STXBP1‐related disorders	19
Issue Information	19
Neurobehavioral deficits and a progressive ictogenesis in the tetrodotoxin model of epileptic spasms	19
Sustained rescue of seizure control in patients with highly refractory chronic epilepsy using empiric immunotherapy	19
Fluoxetine accelerates epileptogenesis and magnifies disease severity in a rat model of acquired epilepsy	19
Efficacy of neuromodulation of the pulvinar nucleus for drug‐resistant epilepsy	19
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Epilepsia – May 2023 – Announcements	19
Bridged bicyclic compounds: Comprehending a novel compound class as potential anti‐seizure agents	19
Epilepsia – September 2025 Announcements	18
Drug resistance in epilepsy: A reappraisal of the definition is needed	18
Long‐term seizure and psychosocial outcomes of patients with ring chromosome 20 syndrome: A cohort study of 47 cases	18
Evaluating crowdsourcing for ICU EEG annotation: A comparison with expert performance	18
Semiautomatic interictal electric source localization based on long‐term electroencephalographic monitoring: A prospective study	18
Peri‐ictal respiratory dysfunction: Expanding the association between mTOR pathway disorders and ictal central apnea	18
A knowledge synthesis of health research reporting standards relevant to epilepsy surgery	18
A systems medicine strategy to predict the efficacy of drugs for monogenic epilepsies	18
Community‐based epilepsy care in an onchocerciasis‐endemic area: A 3‐year cohort study in Mahenge, Tanzania	18
Electroencephalographic findings and 5‐year risk of posttraumatic epilepsy after mild traumatic brain injury: Insights from Second Karabakh War veterans	18
Clinical phenotypic spectrum of NRXN1 microdeletions and their association with epilepsy: A system	18
Neurological morbidity of surgery for suprasylvian operculoinsular epilepsy	18
Antiseizure medications in the World Health Organization list of “essential medicines”	18
Neurophotonic methods in approach to in vivo animal epileptic models: Advantages and limitations	18
Fast activity chirp patterns in focal seizures from patients and animal models	18
Epilepsia – June 2024 Announcements	18
How often do caregivers attend their child when a seizure detection device alerts for a nocturnal major motor seizure?	17
Sudden unexpected death in epilepsy during cenobamate clinical development	17
Chemogenetic astrocyte modulation reduces spontaneous hippocampal discharges and metabolite changes in an epilepsy mouse model	17
Spectrum of epileptogenicity in different cortical tuber radiological subtypes: A stereoelectroencephalographic study	17
Add‐on treatment with cenobamate is already effective at low doses in refractory focal epilepsy: A prospective observational study	17
Response: “The importance of methodological context in pediatric VNS outcome reporting”	17
Abstracts	17
Concordance between focal brain temperature elevations and focal edema in temporal lobe epilepsy	17
Practical considerations in epilepsy neurostimulation	17
Issue Information	17
Peripheral blood mononuclear cell secretome from patients with autoimmune encephalitis promotes seizures in vitro	17
Factors associated with long‐term outcomes in people with new onset refractory epilepticus: A single‐center cohort study	17
Stereo‐ EEG mapping of visual working memory with task‐related high‐gamma modulations	17
Effect of adenosinergic manipulations on amygdala‐kindled seizures in mice: Implications for sudden unexpected death in epilepsy	17
Do we agree on seizure reduction after vagus nerve stimulation? Interrater reliability of retrospective and prospective seizure frequency ratings from the CONNECTiVOS	17
Dynamic patterns of verbal memory function after an initial decline following temporal lobe resection against epilepsy: Sex‐specific differences in the postoperative course	17
Putative roles for homeostatic plasticity in epileptogenesis	17
Epilepsy in cerebral amyloid angiopathy: an observational retrospective study of a large population	17
Assessing naming and verbal memory in bilingual epilepsy: Challenges and insights for surgical planning	17
Distinct peripheral pro‐inflammatory profile associated with tuberous sclerosis complex and epilepsy	17
Unsupervised clustering of a deeply phenotyped cohort of adults with idiopathic generalized epilepsy	17
Visually or auditorily induced seizures involve the activation of nonhippocampal brain areas and hippocampal removal does not alleviate seizures in a mouse model of temporal lobe epilepsy	17
Electroencephalographic source imaging of spikes with concurrent high‐frequency oscillations is concordant with the clinical ground truth	17
Proof of concept: Portable ultra‐low‐field magnetic resonance imaging for the diagnosis of epileptogenic brain pathologies	17
Epilepsia – September 2023 – Announcements	16
Pharmacokinetics and 180‐day safety of diazepam nasal spray in pediatric patients with epilepsy aged 2–5 years	16
Detection of focal cortical dysplasia: Development and multicentric evaluation of artificial intelligence models	16
Issue Information	16
Telemedicine as a path to bridging inequities in patients with epilepsy	16
Brain molecular mechanisms in Rasmussen encephalitis	16
An interview with Riccardo De Feo, 2023 Epilepsia Prize winner for Basic Science Research	16