OOIR: Observatory of International Research

Papers

(The median citation count of Digestion is 2. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-04-01 to 2024-04-01.)

Article	Citations
Gut Microbiota Dysbiosis Drives the Development of Colorectal Cancer	75
DNA Methylation and Genetic Aberrations in Gastric Cancer	56
Management of Severe Acute Pancreatitis: An Update	53
Epidemiological Trends and Future Perspectives of Gastric Cancer in Eastern Asia	52
The Ideal <b><i>Helicobacter pylori</i></b> Treatment for the Present and the Future	34
New and Emerging Treatments for Inflammatory Bowel Disease	29
Epidemiological Review of Gastroesophageal Junction Adenocarcinoma in Asian Countries	25
Expert Opinions on the Current Therapeutic Management of Inflammatory Bowel Disease during the COVID-19 Pandemic: Japan IBD COVID-19 Taskforce, Intractable Diseases, the Health and Labor Sciences Rese	23
Positioning and Usefulness of Biomarkers in Inflammatory Bowel Disease	21
Factors Associated with Fibrosis during Colorectal Endoscopic Submucosal Dissection: Does Pretreatment Biopsy Potentially Elicit Submucosal Fibrosis and Affect Endoscopic Submucosal Dissection Outcome	19
Alteration of the Gut Microbiome in Inflammatory Bowel Disease	18
The Impact of a Mediterranean Diet on the Gut Microbiome in Healthy Human Subjects: A Pilot Study	16
Endoscopic and Clinicopathological Features of Superficial Non-Ampullary Duodenal Tumor Based on the Mucin Phenotypes	16
Role of Ulcerative Colitis Endoscopic Index of Severity (UCEIS) versus Mayo Endoscopic Subscore (MES) in Predicting Patients′ Response to Biological Therapy and the Need for Colectomy	16
Histologic and Clinical Effects of Different Topical Corticosteroids for Eosinophilic Esophagitis: Lessons from an Updated Meta-Analysis of Placebo-Controlled Randomized Trials	15
An Update on Eosinophilic Esophagitis: Etiological Factors, Coexisting Diseases, and Complications	14
Assessment of Prophylactic Carbapenem Antibiotics Administration for Severe Acute Pancreatitis: An Updated Systematic Review and Meta-Analysis	14
Application of Artificial Intelligence in Early Gastric Cancer Diagnosis	14
Gut Microbiota Profiles in Early- and Late-Onset Colorectal Cancer: A Potential Diagnostic Biomarker in the Future	13
Mucosa-Associated Microbiota in Patients with Irritable Bowel Syndrome: A Comparison of Subtypes	13
Questionnaire-Based Survey on Epidemiology of Functional Gastrointestinal Disorders and Current Status of Gastrointestinal Motility Testing in Asian Countries	12
Gastrointestinal Quality of Life in Gastroesophageal Reflux Disease: A Systematic Review	12
Significance of 5-Aminosalicylic Acid Intolerance in the Clinical Management of Ulcerative Colitis	12
Predictive Factors for Short-Term Survival after Non-Curative Endoscopic Submucosal Dissection for Early Gastric Cancer	11
Clue of Diagnosis for Autoimmune Gastritis	11

Indications of Endoscopic Submucosal Dissection for Undifferentiated Early Gastric Cancer: Current Status and Future Perspectives for Further Expansion	10
Current Opinion about Hepatocellular Carcinoma <10 mm	10
Clinical Characteristics and Treatment Outcomes of Patients with Eosinophilic Esophagitis and Eosinophilic Gastroenteritis	10
Long-Term Prognostic Predictors of Esophageal Squamous Cell Carcinoma Potentially Indicated for Endoscopic Submucosal Dissection	10
Chemoprevention of Oesophageal Squamous-Cell Carcinoma and Adenocarcinoma: A Multicentre Retrospective Cohort Study	10
Detection of Early Gastric Cancer after <b><i>Helicobacter pylori</i></b> Eradication	10
Pathological Diversity of Gastric Cancer from the Viewpoint of Background Condition	9
Endoscopic Ultrasound Elastography as a Novel Diagnostic Method for the Assessment of Hardness and Depth of Invasion in Colorectal Neoplasms	9
Endocytoscopy Is Useful for the Diagnosis of Superficial Nonampullary Duodenal Epithelial Tumors	9
Immunohistochemical Analysis of Mismatch Repair Gene Proteins in Early Gastric Cancer Based on Microsatellite Status	8
Efficacy and Safety of Vonoprazan and Amoxicillin Dual Therapy for Helicobacter pylori Eradication: A Systematic Review and Meta-Analysis	8
Frame-by-Frame Analysis of a Commercially Available Artificial Intelligence Polyp Detection System in Full-Length Colonoscopies	8
The Correlation between Vitamin D Levels and the Risk of Postoperative Recurrence in Crohn’s Disease	8
Week 2 Symptomatic Response with Vedolizumab as a Predictive Factor in Japanese Anti-TNFα-Naive Patients with Ulcerative Colitis: A post hoc Analysis of a Randomized, Placebo-Controlled Phase 3 Trial	8
Comprehensive Analysis of microRNA Profiles in Organoids Derived from Human Colorectal Adenoma and Cancer	8
A Questionnaire-Based Survey on the Impact of the COVID-19 Pandemic on Gastrointestinal Endoscopy in Asia	8
Transitional Care for Patients with Inflammatory Bowel Disease: Japanese Experience	8
Clinical Outcomes of Vonoprazan-Treated Patients after Endoscopic Submucosal Dissection for Gastric Neoplasms: A Prospective Multicenter Observation Study	8
Duodenal Histological Findings and Risk of Coeliac Disease in Subjects with Autoimmune Atrophic Gastritis: A Retrospective Evaluation	7
Clinicopathological and Endoscopic Features of Raspberry-Shaped Gastric Cancer in Helicobacter pylori-Uninfected Patients	7
Clinical Evaluation of Computer-Aided Colorectal Neoplasia Detection Using a Novel Endoscopic Artificial Intelligence: A Single-Center Randomized Controlled Trial	7
Recent Advances in Molecular Imaging of Colorectal Tumors	7
Association of Serum Triglyceride Levels with Severity in Acute Pancreatitis: Results from an International, Multicenter Cohort Study	7
Endoscopic Submucosal Dissection Using EndoTrac, a Novel Traction Device	7
International Observational Survey of the Effectiveness of Personal Protective Equipment during Endoscopic Procedures Performed in Patients with COVID-19	7
Current Status and Future Prospects of Inflammatory Bowel Disease Genetics	7
The Cutting Edge Research of Functional Gastrointestinal Disorders in Japan: Review on JGA Core Symposium 2018–2020	6
Identification of Biomarkers Associated with the Prognoses of Colorectal Cancer Patients	6
Splenic Rhythms and Postprandial Dynamics in Physiology, Portal Hypertension, and Functional Hyposplenism: A Review	6
Impaired Mucosal Integrity in Proximal Esophagus Is Involved in Development of Proton Pump Inhibitor-Refractory Nonerosive Reflux Disease	6
Gastric Adenoma: A High Incidence Rate of Developing Carcinoma and Risk of Metachronous Gastric Cancer according to Long-Term Follow-Up	6
What’s New with Endoscopic Treatments for Early Gastric Cancer in the “Post-ESD Era”?	6
A Prospective Multicenter Study on the Prevalence of Fructose Malabsorption in Patients with Chronic Inflammatory Bowel Disease	6
Is Additional Gastrectomy Required for Elderly Patients after Endoscopic Submucosal Dissection with Endoscopic Curability C-2 for Early Gastric Cancer?	6
Prognostic Impact and Clinicopathological Features of Multiple Colorectal Cancers and Extracolorectal Malignancies: A Nationwide Retrospective Study	6
Analysis of Barrett’s Esophagus and Its Risk Factors: A Cross-Sectional Study of 10,122 Subjects at a Japanese Health Examination Center	6
Contribution of Serotonin 3A Receptor to Motor Function and Its Expression in the Gastrointestinal Tract	6
Efficacy and Safety of Fingerroot (Boesenbergia rotunda) Extract in Patients with Functional Dyspepsia: A Randomized, Placebo-Controlled Trial	5
Expression of Oncogenic Molecules in Pediatric Ulcerative Colitis	5
Diagnostic Accuracy and Therapeutic Efficacy of Digital Single-Operator Cholangioscopy for Biliary Lesions and Stenosis	5
Chest Pain after Endoscopic Submucosal Dissection for Esophageal Cancer: The Simple and Clinically Useful Surrogate Marker for Transmural Thermal Injury by Electrocoagulation	5
Risk Factors for Nephrotoxicity due to Tacrolimus Therapy for Ulcerative Colitis	5
The Compositional Structure of the Small Intestinal Microbial Community via Balloon-Assisted Enteroscopy	5
Lipoprotein and Metabolic Profiles Indicate Similar Cardiovascular Risk of Liver Steatosis and NASH	5
A Novel Noninvasive Method for Quantitative Detection of Colonic Dysmotility Using Real-Time Ultrasonography	5
Efficacy of Magnifying Narrow Band Imaging with Acetic Acid Spray in Diagnosing Superficial Non-Ampullary Duodenal Epithelial Tumors	5
Serum Exosomal Dicer Is a Useful Biomarker for Early Detection of Differentiated Gastric Adenocarcinoma	4
Approach to the Seamless Management of Inflammatory Bowel Disease, Considering Special Situations, Shared Decision-Making, and Disease Burden	4
Risk of Vaccine-Preventable Infections in Swiss Adults with Inflammatory Bowel Disease	4
Covering Post-Endoscopic Submucosal Dissection Ulcers in Miniature Swine with Hexanoyl (Hx:C6) Group-Modified Alkaline-Treated Gelatin Porous Film (HAG) Induces Proper Healing by Decreasing Inflammati	4

Ghrelin Gene Polymorphisms in Irritable Bowel Syndrome	4
Lack of Increased Risk of Lymphoma with Thiopurine Therapy Regardless of Dose and Duration of Treatment in Japanese Patients with Inflammatory Bowel Diseases	4
Clinical Characteristics of Intramucosal Gastric Cancers with Lymphovascular Invasion Resected by Endoscopic Submucosal Dissection	4
Usefulness of Magnifying Endoscopy with Narrow-Band Imaging for Diagnosing Mixed Poorly Differentiated Gastric Cancers	4
Long-Term Outcomes in Patients with Post-Bulbar Ulcer Bleeding Compared to Bulbar Ulcer Bleeding in the Duodenum	4
Clinical Guidelines for Diagnosis and Management of Peutz-Jeghers Syndrome in Children and Adults	4
Accurate Evaluation of Residual Common Bile Duct Stones by Endoscopic Ultrasound: A Two-Step Check Method for Residual Stone Clearance	4
Double-Balloon Enteroscopy in Detecting Small-Bowel Neuroendocrine Neoplasms: A Single-Center Prospective Study	4
Fecal Lactoferrin and Other Putative Fecal Biomarkers in Crohn’s Disease: Do They Still Have a Potential Clinical Role?	4
Saliva Secretion Is Significantly Lower in Female Patients with Mild Reflux Esophagitis than in Female Healthy Controls	4
Monocyte-Derived Hepatocyte-Like Cell Test: A Novel Tool for in vitro Identification of Drug-Induced Liver Injury in Patients with Herbal or Dietary Supplements	4
Clinical Features Focusing on Extraintestinal Manifestations in Japanese Patients with Inflammatory Bowel Diseases: Far East 1000	3
Proton Pump Inhibitor Treatment Has Little Effects on Secretion of Saliva in Patients with Proton Pump Inhibitor-Responsive Mild Reflux Esophagitis and Non-Erosive Reflux Disease	3
Leucine-Rich Alpha-2 Glycoprotein May Be Predictive of the Adalimumab Trough Level and Antidrug Antibody Development for Patients with Inflammatory Bowel Disease: A Sub-Analysis of the PLANET Study	3
Clinical Significance and Properties of IFN-γ<sup>+</sup>IL-17<sup>+</sup> Th17 Cells in Liver Injury Associated with Chronic Hepatitis B Virus Infection	3
The Regional Specificity of Mucosa-Associated Microbiota in Patients with Distal Colorectal Cancer	3
Safety and Efficacy of Self-Expandable Metallic Stent Placement Using Low Radial Force Stent for Malignant Dysphagia after Radiotherapy	3
Surgical Therapy in Patients with Colorectal Liver Metastases	3
Current Status of Endoscopic Full-Thickness Resection for Gastric Subepithelial Tumors: A Literature Review Over Two Decades	3
Evidence-Based Approach to the Discontinuation of Immunomodulators or Biologics in Inflammatory Bowel Disease	3
Repeated Lusutrombopag Treatment for Thrombocytopenia in Patients with Chronic Liver Disease	3
A Multicenter Prospective Survey on Early-Onset Inflammatory Bowel Disease in Japan	3
Comparison of High-Resolution Manometry in Patients Complaining of Dysphagia among Patients with or without Diabetes Mellitus	3
Relationship between Immunophenotype and Clinicopathological Findings for Superficial Nonampullary Duodenal Epithelial Tumor	3
Safety and Effectiveness of Endoscopic Band Ligation for Colonic Diverticular Bleeding in Elderly Patients	3
Near-Infrared Photoimmunotherapy for Cancers of the Gastrointestinal Tract	3
Effectiveness of Chemoradiotherapy for Metachronous Esophageal Squamous Cell Carcinoma	3
A Multicenter Prospective Validation Study on Selective Endoscopic Resection of Sessile Serrated Lesions Using Magnifying Colonoscopy in Clinical Practice	3
Efficacy of Sodium Carboxymethylcellulose Compared to Sodium Hyaluronate as Submucosal Injectant for Gastric Endoscopic Submucosal Dissection: A Randomized Controlled Trial	3
Effects of Colchicine on NSAID-Induced Severe Small Intestinal Damage: A Pilot Study	2
Interleukin-1β as a Predictor of Glucocorticoid Response in Ulcerative Colitis	2
Safety of Endoscopic Mucosal Resection Using a Bipolar Snare for Superficial Nonampullary Duodenal Epithelial Tumors and the Predictive Factors of Piecemeal Resection	2
Ustekinumab Improves Active Crohn’s Disease by Suppressing the T Helper 17 Pathway	2
Polypoid Nodule Scar after Gastric Endoscopic Submucosal Dissection: Not So Uncommon after Resection of Neoplasms Located in the Antrum	2
Targeted Metabolomic Profiling of Plasma Samples in Gastric Cancer by Liquid Chromatography-Mass Spectrometry	2
Evaluation of Microvascular Patterns Alone Using Endocytoscopy with Narrow-Band Imaging for Diagnosing Gastric Cancer	2
Is There an Increasing Incidence of Gastroesophageal Junctional Adenocarcinoma and Barrett Esophagus in Asia? A Review of Diagnostic Conundrums	2
Predicting Inadequate Bowel Preparation When Using Sodium Picosulfate plus Magnesium Citrate for Colonoscopy: Development and Validation of a Prediction Score	2
Role of a Rare Variant in APC Gene Promoter 1B Region in Classic Familial Adenomatous Polyposis	2
Gastrointestinal Adverse Events Induced by Immune-Checkpoint Inhibitors	2
Relationship between Chemotherapy-Induced Diarrhea and Intestinal Microbiome Composition	2
Gastrointestinal Angiodysplasia in Patients with Severe Aortic Stenosis: The Endoscopic Features of Heyde’s Syndrome	2
Preliminary Comparison of Endoscopic Brush and Net Catheters as the Sampling Tool to Analyze the Intestinal Mucus in the Rectum with Ulcerative Colitis Patients	2
Comparison of Efficacy and Safety between Endoscopic Retrograde Cholangiopancreatography and Percutaneous Transhepatic Cholangial Drainage for the Treatment of Malignant Obstructive Jaundice: A System	2
Comparison of Endoscopic Ultrasonography and Conventional Endoscopy for Prediction of Tumor Depth in Superficial Nonampullary Duodenal Epithelial Tumors	2
Endoscopic Submucosal Dissection for Early Gastric Cancer in Patients Aged 85 Years Old or Older Is Associated with a Good Prognosis Compared to Conservative Treatment without Any Invasive Procedure	2
S100P Expression via DNA Hypomethylation Promotes Cell Growth in the Sessile Serrated Adenoma/Polyp-Cancer Sequence	2
Accuracy of Endoscopic Transpapillary Gallbladder Drainage with Liquid-Based Cytology for Gallbladder Disease	2
Endoscopic Ligation with O-Ring Closure for Mucosal Defects after Rectal Endoscopic Submucosal Dissection: A Feasibility Study (with Video)	2
Development and Application of Regenerative Medicine in Inflammatory Bowel Disease	2