Computers in Biology and Medicine

Article	Citations
Editorial Board	517
Vectorial-based analysis of dual-tracer PET imaging: A proof of concept	472
A self-supervised COVID-19 CT recognition system with multiple regularizations	454
Discrete element method-based simulation system for predicting natural stone evacuation pathways in patients with urolithiasis	425
A novel Harris Hawks Optimization-based clustering method for elucidating genetic associations in osteoarthritis and Diverse Cancer Types	419
Prediction of protein N-terminal acetylation modification sites based on CNN-BiLSTM-attention model	370
AIScholar: An OpenFaaS-enhanced cloud platform for intelligent medical data analytics	368
Discrepancy-based diffusion models for lesion detection in brain MRI	326
Pharmacophore-guided computational modeling of quinolone-ATPase conjugate inhibitors targeting DNA GyrB subunit of Staphylococcus aureus	322
Molecular modelling and experimental validation identified a new therapeutic inhibitor of toxoplasmosis	308
Corrigendum to “Unraveling the molecular landscape of non-small cell lung cancer: Integrating bioinformatics and statistical approaches to identify biomarkers and drug repurposing” [Comput. Biol. Med.	301
Identification of potential agonist-like molecules for α2-adrenergic receptor by multi-layer virtual screening to combat sinusitis	299
Editorial Board	294
Computational prediction of protein folding rate using structural parameters and network centrality measures	288
Data-driven discovery of sparse dynamical model of cardiovascular system for model predictive control	260
Dual-Stream Subspace Clustering Network for revealing gene targets in Alzheimer's disease	255
A computational model of the effects of macronutrients absorption and physical exercise on hormonal regulation and metabolic homeostasis	244
Two-stage error detection to improve electron microscopy image mosaicking	234
Hierarchical cumulative network for unsupervised medical image registration	229
Multi-constraint point set registration with redundant point removal for the registration of coronary arteries	226
A method for predicting linear and conformational B-cell epitopes in an antigen from its primary sequence	215
Context encoder transfer learning approaches for retinal image analysis	211
Stack-AAgP: Computational prediction and interpretation of anti-angiogenic peptides using a meta-learning framework	207
Identification of JUN as determinant of osteoarthritis and its inhibition by the Chinese herbal formulae Zhuanggu Huoxue Tang	203
Identifying indications for novel drugs using electronic health records	201

Diffuse tumors: Molecular determinants shared by different cancer types	198
Development and validation of a neutrophil extracellular traps-related gene signature for lower-grade gliomas	193
The role of the extracellular matrix in the reduction of lateral force transmission in muscle bundles: A finite element analysis	191
Identification of anti-cancer organometallic compounds by inhibition of BCL-2/Bax interactions	185
Carotid single- and dual-layer stents reduce the wall adhesion of platelets by influencing flow and cellular transport	180
Integrating CNN and Bi-LSTM for protein succinylation sites prediction based on Natural Language Processing technique	175
A systematic review on the state-of-the-art strategies for protein representation	173
Quantifying the influence of combined lung and kidney support using a cardiovascular model and sensitivity analysis-informed parameter identification	164
A Three-branch Jointed Feature and Topology Decoder guided by game-theoretic interactions for temporomandibular joint segmentation	156
Dynamical pattern of successive bits to predict the outcomes of the SSRI and rTMS depression therapies using EEG signals	155
A deep learning model combining convolutional neural networks and a selective kernel mechanism for SSVEP-Based BCIs	151
Automated identification of patient subgroups: A case-study on mortality of COVID-19 patients admitted to the ICU	149
Functional identification and prediction of lncRNAs in esophageal cancer	145
DeepSMR: Decoding high-complex motor imagery via subject-dependent multi-feature refinement in deep convolutional networks	140
Unraveling the complexities of pathological voice through saliency analysis	140
Artificial vascular image generation using blood vessel texture maps	139
Artificial intelligence for identification of candidates for device-aided therapy in Parkinson's disease: DELIST-PD study	137
Improved predictive diagnosis of diabetic macular edema based on hybrid models: An observational study	135
A partially shared joint clustering framework for detecting protein complexes from multiple state-specific signed interaction networks	135
Gene-related Parkinson's disease diagnosis via feature-based multi-branch octave convolution network	128
Non-same-scale feature attention network based on BPD for medical image segmentation	124
Dynamic topography analysis of the cornea and its application to the diagnosis of keratoconus	123
Reversing skin cancer adversarial examples by multiscale diffusive and denoising aggregation mechanism	121
Enhancing cell instance segmentation in scanning electron microscopy images via a deep contour closing operator	120
Longitudinal dementia trajectories for Alzheimer’s Disease characterization and prediction	113
Deriving a suitable schedule through robust H∞ and sliding mode control methods for cancer treatment using chemotherapy & anti-angiogenic drugs	113
Classical Simulations on Quantum Computers: Interface-Driven Peptide Folding on Simulated Membrane Surfaces	112
Structure-based design of promising natural products to inhibit thymidylate kinase from Monkeypox virus and validation using free energy calculations	109
Automatic segmentation of intraluminal thrombosis of abdominal aortic aneurysms from CT angiography using a mixed-scale-driven multiview perception network (M2Net) model	108
Beyond accuracy: The need for explainable AI in biomedical voice technology	108
Dynamic Statistical Attention-based lightweight model for Retinal Vessel Segmentation: DyStA-RetNet	108
Bayesian parameter inference and uncertainty-informed sensitivity analysis in a 0D cardiovascular model for intraoperative hypotension	108
You get the best of both worlds? Integrating deep learning and traditional machine learning for breast cancer risk prediction	107
Fine-grained food image classification and recipe extraction using a customized deep neural network and NLP	107
DRBpred: A sequence-based machine learning method to effectively predict DNA- and RNA-binding residues	105
Hybrid neural–mechanistic modeling of leptospirosis transmission with environmental drivers: Evidence from Thailand	105
Synergistic eigenanalysis of covariance and Hessian matrices for enhanced binary classification on health datasets	103
Semi-empirical Anticoagulation Model (SAM): Dose prediction during warfarin therapy	103
LSDVvac: An immunoinformatics database for vaccine design against lumpy skin disease virus	102
SSMT-PANBERT: A single-stage multitask model for phenotype extraction and assertion negation detection in unstructured clinical text	102
CARES: A Corpus for classification of Spanish Radiological reports	102
Prediction of lung cancer metastasis by gene expression	101
Enhancing targeted tumor treatment: A novel fuzzy logic framework for precision drug delivery strategy selection	101
Prediction of colorectal cancer based on taxonomic levels of microorganisms and discovery of taxonomic biomarkers using the Grouping-Scoring-Modeling (G-S-M) approach	100
JoCoRank: Joint correlation learning with ranking similarity regularization for imbalanced fetal brain age regression	100
ST-SRPerf: Continuous spatiotemporal representation for perfusion MRI super-resolution through neural ODE and implicit neural representation	100
Class-Specific Distribution Alignment for semi-supervised medical image classification	100
Numerical analysis of coil designs to expedite fracture healing using dielectrophoresis with S method	99
Deep-learning-based real-time individualization for reduce-order haemodynamic model	98
A comprehensive analysis of single-cell RNA transcriptome reveals unique SPP1+ chondrocytes in human osteoarthritis	97

Counting on AR: EEG responses to incongruent information with real-world context	97
An efficient model for extracting respiratory and blood oxygen saturation data from photoplethysmogram signals by removing motion artifacts using heuristic-aided ensemble learning model	97
SURVS: A Swin-Unet and game theory-based unsupervised segmentation method for retinal vessel	97
MulStack: An ensemble learning prediction model of multilabel mRNA subcellular localization	95
A general sample-weighted framework for epileptic seizure prediction	94
Multiscale differential geometry learning of networks with applications to single-cell RNA sequencing data	92
Structure, sensing and control of pneumatic upper limb rehabilitation system: Review and prospect	91
A computational study of venom as drug library: Discovery of multifunctional astacin-like metalloproteases from Androctonus zagrosensis venom gland transcriptome	90
Eudesma-4(15), 7-dien-1-β-ol, A promising natural drug candidate for Alzheimer's disease targeting the NMDA pathway: GC-MS identification, molecular docking, pharmacokinetic and molecular dynamic anal	90
Revised NMS-driven pipeline for heart valve regurgitation and Kawasaki disease coronary aneurysm localization	90
An efficient image segmentation method for skin cancer imaging using improved golden jackal optimization algorithm	89
Identifying potent natural inhibitors of the hepatitis C virus NS3 protein using multiple computational and molecular approaches	88
KS-TMIL: A K-Stage Transformer approach with multiple instance learning model for ovarian cancer subtype classification	88
Anemia prediction using gene expression programming (GEP) and explainable artificial intelligence approaches	88
DE-JANet: A unified network based on dual encoder and joint attention for Alzheimer’s disease classification using multi-modal data	88
KC-UNIT: Multi-kernel conversion using unpaired image-to-image translation with perceptual guidance in chest computed tomography imaging	88
Optimization of deep learning models for inference in low resource environments	88
Drug repositioning for rosacea disease: Biological TARGET identification, molecular docking, pharmacophore mapping, and molecular dynamics analysis	87
D-glucose-conjugated thioureas containing 2-aminopyrimidine as potential multitarget inhibitors for type 2 diabetes mellitus: Synthesis and biological activity study	87
Detecting IDH and TERTp mutations in diffuse gliomas using 1H-MRS with attention deep-shallow networks	87
Mapping synthetic binding proteins epitopes on diverse protein targets by protein structure prediction and protein-protein docking	87
Performance of multilabel machine learning models and risk stratification schemas for predicting stroke and bleeding risk in patients with non-valvular atrial fibrillation	87
CauDR: A causality-inspired domain generalization framework for fundus-based diabetic retinopathy grading	86
Deep learning-based feature discovery for decoding phenotypic plasticity in pediatric high-grade gliomas single-cell transcriptomics	86
Automated mitral valve segmentation in PLAX-view transthoracic echocardiography for anatomical assessment and risk stratification	85
Identifying fetal status with fetal heart rate: Deep learning approach based on long convolution	85
Mass diffusion in multi-layer systems: an electrical analogue modelling approach	85
EpiTEAmDNA: Sequence feature representation via transfer learning and ensemble learning for identifying multiple DNA epigenetic modification types across species	85
Modelling of thrombus formation, growth and embolisation in the left atrial appendage under atrial fibrillation	84
Hybrid offline and self-knowledge distillation for acute ischemic stroke lesion segmentation from non-contrast CT scans	84
Multi-label classification of fundus images with graph convolutional network and LightGBM	83
Targeting pulmonary fibrosis through Solanum xanthocarpum phytochemicals: A synergistic network pharmacology and docking investigation	83
Potential and challenges of generative adversarial networks for super-resolution in 4D flow MRI	83
M3-Net++: A multi-scale, multi-level, multi-stream network for nuclei segmentation in breast cancer histopathology using hierarchical context extraction and hybrid loss optimization	82
AI-based bi-modal fusion system for automated clinical pain monitoring	82
Simulated annealing aided genetic algorithm for gene selection from microarray data	82
How CLSPN could demystify its prognostic value and potential molecular mechanism for hepatocellular carcinoma: A crosstalk study	81
Enhanced depression detection from speech using Quantum Whale Optimization Algorithm for feature selection	81
Automated mitral inflow Doppler peak velocity measurement using deep learning	81
Contrastive learning based method for X-ray and CT registration under surgical equipment occlusion	81
Context-aggregator: An approach of loss- and class imbalance-aware aggregation in federated learning	80
Towards a better understanding of TF-DNA binding prediction from genomic features	80
Integrating biocomputational techniques for Breast cancer drug discovery via the HER-2, BCRA, VEGF and ER protein targets	80
Pedicle drilling force control of a robotic surgical system via spine-soft tissue coupling model and parameters optimization	78
ILSHIP: An interpretable and predictive model for hypothyroidism	78
Exploring the spike glycoprotein-encoding gene of SARS-CoV-2 using multifractal analysis: Unveiling structural complexity and implications for viral transmission	78
Deep learning and machine learning approaches to classify stomach distant metastatic tumors using DNA methylation profiles	77
Prostate158 - An expert-annotated 3T MRI dataset and algorithm for prostate cancer detection	77
Insights from explainable AI in oesophageal cancer team decisions	77
FCSU-Net: A novel full-scale Cross-dimension Self-attention U-Net with collaborative fusion of multi-scale feature for medical image segmentation	76
IVD fibrosis and disc collapse comprehensively aggravate vertebral body disuse osteoporosis and zygapophyseal joint osteoarthritis by posteriorly shifting the load transmission pattern	76
Visual prior-based cross-modal alignment network for radiology report generation	76
Effect of tumor heterogeneity on enhancing drug delivery to vascularized tumors using thermo-sensitive liposomes triggered by hyperthermia: A multi-scale and multi-physics computational model	76
AELGNet: Attention-based Enhanced Local and Global Features Network for medicinal leaf and plant classification	76
Emotion recognition in EEG signals using deep learning methods: A review	76
Fusion-m6A: A lightweight hybrid deep learning framework for RNA m6A site prediction	76
HOTGpred: Enhancing human O-linked threonine glycosylation prediction using integrated pretrained protein language model-based features and multi-stage feature selection approach	76
Analysis of domain shift in whole prostate gland, zonal and lesions segmentation and detection, using multicentric retrospective data	76
AI unleashed: A meta-analysis transforming radiological insights in diagnosing abdominal infections	76
Simulated effects of the peripheral musculoskeletal system on hand tremor	75
Imaging and machine learning reveal pigment ring spatial characteristics in vitiligo progression	74
REDDA: Integrating multiple biological relations to heterogeneous graph neural network for drug-disease association prediction	73
MCA-net: A multi-task channel attention network for Myocardial infarction detection and location using 12-lead ECGs	73
Eye movement analysis for real-world settings using segmented linear regression	72
A deep learning based model using RNN-LSTM for the Detection of Schizophrenia from EEG data	72
Disclosing neonatal pain in real-time: AI-derived pain sign from continuous assessment of facial expressions	71
Red blood cell passage through deformable interendothelial slits in the spleen: Insights into splenic filtration and hemodynamics	71
MOIS-SAM2: Exemplar-based segment anything model 2 for multi-lesion interactive segmentation of neurofibromas in whole-body MRI	71
Evaluation of the mechanical behaviour of the expandable wedge locked nail fixation in retrograde use: A finite element study	70
Predictive modeling for early detection of biliary atresia in infants with cholestasis: Insights from a machine learning study	70
Advances in disease detection through retinal imaging: A systematic review	70
Optimizing multimodal models for medical visual question answering: A comparative study of LoRA and AdaLoRA on VQA-RAD and SLAKE-VQA	70
Automatic eczema classification in clinical images based on hybrid deep neural network	70
Parameter sensitivity and critical transition anticipation in bistable toxin-antitoxin dynamics	70
Efficient sleep apnea detection using single-lead ECG: A CNN-Transformer-LSTM approach	70
Wearable-based human flow experience recognition enhanced by transfer learning methods using emotion data	69
Machine-learning-guided control of a pulsed cold atmospheric plasma jet reveals a voltage-dependent discharge transition relevant to diabetic wound healing	68
Diagnosis of ADHD in children from EEG signals using amplitude modulation features	68
Efficient colorectal cancer classification from histopathological images utilizing lightweight convolutional neural networks	68
LEGEND: Lorentzian electro-modal graph encoder for neural decoding for SCI rehabilitation	68

Physics-guided transformation of breathomic feature spaces into disease-specific representations for respiratory disease classification	67
Enhancing and advancements in deep learning for melanoma detection: A comprehensive review	67
ECG arrhythmia classification via wavelet-driven feature extraction and swarm-optimised gradient boosting	67
Identification of lncRNA associated with the SERPINE1 gene in colorectal cancer through TGF-β pathway	67
An improved RIME optimization algorithm for lung cancer image segmentation	67
Pathogenicity classification of missense mutations based on deep generative model	66
Adaptive nonlinear filtering algorithms for removal of non-stationary noise in electronystagmographic signals	66
KNU-DTI: KNowledge United Drug-Target Interaction prediction	66
Explainable AI-driven prediction of influenza neuraminidase inhibitors using a stacked ensemble-learning framework	66
Temporal relative transformer encoding cooperating with channel attention for EEG emotion analysis	66
A novel mobile phone and tablet application for automatized calculation of pain extent	65
Thyroid region prior guided attention for ultrasound segmentation of thyroid nodules	65
Predicting lung cancer survival based on clinical data using machine learning: A review	65
Assessing clinical utility of machine learning and artificial intelligence approaches to analyze speech recordings in multiple sclerosis: A pilot study	65
Graph neural network-based subgraph analysis for predicting adverse drug events	65
A review of deep learning-based information fusion techniques for multimodal medical image classification	65
Predicting diameter and tensile strength of electrospun fibers for biomedicine: A comparison of Box-Behnken design, traditional machine learning and deep learning	64
DrugormerDTI: Drug Graphormer for drug–target interaction prediction	64
Sparse Dynamic Volume TransUNet with multi-level edge fusion for brain tumor segmentation	64
A novel hybrid ViT-LSTM model with explainable AI for brain stroke detection and classification in CT images: A case study of Rajshahi region	63
The role and potential of computer-aided drug discovery strategies in the discovery of novel antimicrobials	63
Molecular hybridization assisted multi-technique approach for designing USP21 inhibitors to halt catalytic triad-mediated nucleophilic attack and suppress pancreatic ductal adenocarcinoma progression:	63
Electroanatomical mapping of the stomach with simultaneous biomagnetic measurements	63
MG-Net: Multi-level global-aware network for thymoma segmentation	62
Editorial Board	62
Genetic algorithm based image reconstruction applying the digital holography process with the Discrete Orthonormal Stockwell Transform technique for diagnosis of COVID-19	62
Identification of telomere-associated gene signatures to predict prognosis and drug sensitivity in glioma	62
Transcriptome analysis displays new molecular insights into the mechanisms of action of Mebendazole in gastric cancer cells	61
FIM: A fatigued-injured muscle model based on the sliding filament theory	61
SEPO-FI: Deep-learning based software to calculate fusion index of muscle cells	61
Spatiotemporal modeling of host–pathogen interactions using level-set method	61
Role of [18F]-PSMA-1007 PET radiomics for seminal vesicle invasion prediction in primary prostate cancer	61
A fully-convolutional residual encoder-decoder neural network to localize breast cancer on histopathology images	61
Characterizing patients at higher cardiovascular risk for prescribed stimulants: Learning from health records data with predictive analytics and data mining techniques	61
SWTRU: Star-shaped Window Transformer Reinforced U-Net for medical image segmentation	61
Pathological prognosis classification of patients with neuroblastoma using computational pathology analysis	61
Classifying alkaliphilic proteins using embeddings from protein language model	60
Mechanical modeling of the maturation process for tissue-engineered implants: Application to biohybrid heart valves	60
Identification of molecular and cellular infection response biomarkers associated with anthrax infection through comparative analysis of gene expression data	60
A response-threshold method for early cancer diagnosis and monitoring via swarms of nanorobots	60
Enhanced single-cell RNA-seq embedding through gene expression and data-driven gene-gene interaction integration	60
Torque modulation mechanism of the knee joint during balance recovery	60
DYNAFormer: Enhancing transformer segmentation with dynamic anchor mask for medical imaging	60
Effective fall detection and post-fall breath rate tracking using a low-cost CW Doppler radar sensor	59
Fractional-order safe mental-health corridor modelling with Matignon spectral analysis of post-pandemic fatigue-to-recovery dynamics	59
Impact of workflow variability on image-based intracranial aneurysm hemodynamics	59
Modelling antibiotic delivery from functionally graded materials to target biofilm-associated infections	59
Characterization of cancer subtypes associated with clinical outcomes by multi-omics integrative clustering	59
Optimized Complex-Valued Spatio-Temporal Graph Convolutional Networks for attention deficit hyperactivity disorder detection in pediatric EEG signals	59
Alcohol patch test with hue-saturation-value model analysis predicts ALDH2 genetic polymorphism	59
Breast cancer detection and classification: A study on the specification and implementation of multilayer perceptron analog artificial neural networks	59
PNMC: Four-dimensional conebeam CT reconstruction combining prior network and motion compensation	58
Exploring molecular mechanisms of diazinon toxicity in HT22 hippocampal neurons through integrated miRNA and mRNA profiling	58
GeneDX-PBMC: An adversarial autoencoder framework for unlocking Alzheimer's disease biomarkers using blood single-cell RNA sequencing data	58
A mechanobiological model for tumor spheroid evolution with application to glioblastoma: A continuum multiphysics approach	57
Ce	57
Automated generation of image-based subject-specific spine models for adult spinal deformity: Development and kinematic evaluation	57
Artificial intelligence derived categorizations significantly improve HOMA IR/β indicators: Combating diabetes through cross-interacting drugs	57
Evaluation of Cellpose segmentation with sequential thresholding for instance segmentation of cytoplasms within autofluorescence images	57
Automatic segmentation and classification of Papanicolaou-stained cells and dataset for oral cancer detection	57
Novel classification of brain vascular tortuosity measures: A systematic review	56
ACP-MLC: A two-level prediction engine for identification of anticancer peptides and multi-label classification of their functional types	56
Analysis of power law fluid for nutritional transport in the human capillary	56
Predicted and Explained: Transforming drug discovery with AI for high-precision receptor-ligand interaction modeling and binding analysis	56
A mathematical model of tissue axial and radial diffusion in the microvasculature for intravascular microscopy and phosphorescence quenching data	56
Medical application of deep-learning-based head pose estimation from RGB image sequence	55
Individual thigh muscle and proximal femoral features predict displacement in femoral neck Fractures: An AI-driven CT analysis	55
Analysis and design of antithetic proportional-integral-derivative biocontrol-systems with species dilution	55
Bone marrow sparing oriented multi-model image registration in cervical cancer radiotherapy	55
Enhancing nuclei segmentation in breast histopathology images using U-Net with backbone architectures	54
Genomic instability-related twelve-microRNA signatures for predicting the prognosis of gastric cancer	54
A multi-granularity convolutional neural network model with temporal information and attention mechanism for efficient diabetes medical cost prediction	54
CISCA and CytoDArk0: A cell instance segmentation and classification method for histo(patho)logical image Analyses and a new, open, Nissl-stained dataset for brain cytoarchitecture studies	54
Extensive T1-weighted MRI preprocessing improves generalizability of deep brain age prediction models	54
Editorial Board	54
Biochemical reaction network topology defines dose-dependent Drug–Drug interactions	53
SLT-Net: A codec network for skin lesion segmentation	53
Dynamic modeling of antibody repertoire reshaping in response to viral infections	53
Interplay of mutations, alternate mechanisms, and treatment breaks in leukaemia: Understanding and implications studied with stochastic models	53
PIPE-Net: A pyramidal-input-parallel-encoding network for the segmentation of corneal layer interfaces in OCT images	53
SparseMorph: A weakly-supervised lightweight sparse transformer for mono- and multi-modal deformable image registration	53
Respiratory modulation of the heart rate: A potential biomarker of cardiorespiratory function in human	53
Semi-supervised peripapillary atrophy segmentation with shape constraint	52
Deep networks for behavioral variant frontotemporal dementia identification from multiple acquisition sources	52
Cross attention guided multi-scale feature fusion for false-positive reduction in pulmonary nodule detection	52
Cancer-inspired genomics mapper model for the generation of synthetic DNA sequences with desired genomics signatures	52
Multi-scale, multi-dimensional binocular endoscopic image depth estimation network	51
A Decision Support System Based on multi-head convolutional and Recurrent Neural Networks for assisting physicians in diagnosing ADHD	51
Tsallis statistics enhanced logistic regression for gene expression classification	51
Patient-specific investigation into plaque rupture risk due to catheter tracking during TAVR	51
A sleep staging model on wavelet-based adaptive spectrogram reconstruction and light weight CNN	51
Lightweight triangular mesh deformable reconstruction for low quality 3D organ models: Thickness noise and uneven topology	51
Guardian-BERT: Early detection of self-injury and suicidal signs with language technologies in electronic health reports	51
A simplified method for relapsing-remitting multiple sclerosis detection: Insights from resting EEG signals	51
Identification of drug targets in pan-drug resistant Acinetobacter baumannii via whole genome sequencing and subtractive genomics	51