Clinical Radiology

Article	Citations
Re: Financial implications of CT-guided lung biopsy in a tertiary centre: a radiologist's perspective. A reply	69
Contents	59
Caesarean-section scar endometriosis (CSSE): clinical and imaging fundamentals of an underestimated entity	48
Automated detection of enteric tubes misplaced in the respiratory tract on chest radiographs using deep learning with two centre validation	44
Radiomics-based distinction of small (≤2 cm) hepatocellular carcinoma and precancerous lesions based on unenhanced MRI	42
Enabling early detection of knee osteoarthritis using diffusion–relaxation correlation spectrum imaging	35
Radiological–pathological correlation in diffuse idiopathic pulmonary neuroendocrine cell hyperplasia (DIPNECH): imaging and histopathology	35
RCR meetings	32
Imaging features and management of tuberculomas: a review of cases and literature	29
When to stop? Mammographic surveillance in breast cancer survivors aged 70 years and older	25
The diagnosis of osteoporotic vertebral fractures redux	25
Combination CT and MRI shoulder arthrography: a novel technique and improved patient journey	25
A national survey investigating the impact of the COVID-19 pandemic on core and higher breast radiology training in the UK	24
Quality of reporting of artificial intelligence studies: Lessons learnt from a systematic review of the literature	24
The role of multiparametric MRI in differentiating uterine leiomyosarcoma from benign degenerative leiomyoma and leiomyoma variants: a retrospective analysis	23
Barriers to research in interventional radiology within the UK	23
RCR meetings	22
Magnetic resonance imaging (MRI)-based intratumoral and peritumoral radiomics for prognosis prediction in glioma patients	22
MRI-based radiomics analysis of bladder cancer: prediction of pathological grade and histological variant	22
MRI parameters for predicting the effect of ultrasound-guided high-intensity focused ultrasound in the ablation of uterine fibroids	22
Nomogram for evaluating coronary revascularisation necessity based on multi-parameter coronary CT angiography	21
Leadership: virtual special issue	19
Commentary on: a bump in the night: a 15-year retrospective analysis of urgent inpatient and emergency CT reporting out of hours in a tertiary referral centre	18
Comparison of a covered metallic ureteral stent and a double-J stent for malignant ureteral obstruction in advanced gastric cancer	18
Factors influencing the detection rate of fumarate peak in 1H MR spectroscopy of fumarate hydratase-deficient renal cell carcinoma at 3 T MRI	17

Multimodality imaging review of breast vascular lesions	17
Assessing the diagnostic accuracy and interobserver agreement of MRI perfusion in differentiating disease progression and pseudoprogression following treatment for glioblastoma in a tertiary UK centre	17
Contents	16
Predicting subsolid pulmonary nodules before percutaneous needle biopsy: a comparison of artificial neural network and biopsy results	16
Response evaluation of locoregional therapies in combined hepatocellular–cholangiocarcinoma and intrahepatic cholangiocarcinoma versus hepatocellular carcinoma: a propensity score matched study	15
Ultrasound-guided day-case wide-bore percutaneous mucin aspiration in advanced pseudomyxoma peritonei	15
Measurement of oesophageal hiatus surface area by multiplanar reconstruction of MDCT: relationship with lower oesophageal sphincter pressure and acid reflux	15
Chest radiography predictor of COVID-19 adverse outcomes. A lesson learnt from the first wave	15
The prevalence of neovascularity in rotator cuff tendinopathy: comparing conventional Doppler with superb microvascular imaging	15
Re: Quantification of peak blood flow velocity at the cardiac valve and great thoracic vessels by four-dimensional flow and two-dimensional phase-contrast MRI compared with echocardiography: a systema	15
Re: Ultrasound-guided lymph node sampling: accuracy of FNAC, end-cutting (Franseen), and side-cutting (Temno) needle biopsy techniques	15
Interdepartmental communication in emergency radiology: Documentation of referrer opinion on A&E radiographs	14
Improving rationale for contrast CT in differentiated thyroid cancer	14
The accuracy of silent-scan MRA in the assessment of treated intracranial aneurysms compared with TOF-MRA and DSA	14
Diagnostic accuracy and complications of image-guided core needle biopsy of lung lesions	14
Cardiac CT dose reduction	14
CT signs useful for suggesting usual interstitial pneumonia due to connective tissue disease versus idiopathic pulmonary fibrosis	14
Re: Clinical evaluation of a deep-learning-based computer-aided detection system for the detection of pulmonary nodules in a large teaching hospital	14
Use of functional liver imaging score with MultiHance (gadobenate dimeglumine) in chronic liver disease and its correlation with the Child-Pugh score	14
The limping child: Is it septic arthritis? A tertiary centre clinical and radiological guideline	14
Re-audit of a bespoke alerting system for significant unexpected cancer on radiological examinations	14
Institution of a two-week wait brain/CNS ‘cancer exclusion’ imaging pathway	13
Adequacy of coronal FIESTA images in gynaecological MR	13
Evaluation of pancreatic masses: Multidetector CT and endoscopic ultrasound correlation	13
Abnormal tongue discoloration following radioactive iodine-131 ablation therapy for papillary cancer thyroid	13
Cherubism with orbital involvement associated with Noonan syndrome	13
One-stop prostate MRI biopsy service improving the turnaround times from MRI referral to biopsy	13
Comparison of CTPA and V/Q diagnostic outcomes in postpartum women	13
Pictorial review of the hepatobiliary phase appearances of colorectal liver metastasis with gadobenate dimeglumine-enhanced MRI	12
Imaging features of paediatric intussusception diagnosis and reduction	12
Pneumatosis cystoides intestinalis in the paediatric population: A radiological diagnostic dilemma	12
Neurological manifestations of HIV	12
Extreme stenting of the GI tract	12
Introduction of an electronic referral database for the Mersey on-call hub	12
Elbow tendonitis and its mimics	12
CT imaging of benign and malignant gastric disease: A pictorial review	12
Imaging characteristics of axial spondyloarthritis	12
A review of MR rectal tumours: A review of imaging quality	11
Safety and efficacy of percutaneous plugged splenic biopsy as an alternative to splenectomy for diagnosing disorders of the spleen	11
Suboptimal CT imaging due to contrast medium allergy: A UK tertiary hospital experience	11
Deep venous thrombosis: More than meets the eye	11
Impact of COVID-19 on CT imaging in a tertiary care hospital	11
Trauma in a non-trauma centre: Outcomes and incidental findings	11
Anomalous coronary arteries: A pictorial review	11
Coronary artery calcification on CTPA: Should I say or should I no?	11
Spectral virtual non-contrast reconstruction in the detection of intramural haematoma	11
Sport-related head injuries: What is the burden on the radiology service? A single-centre experience	11
Paediatric fluoroscopic intussusception reduction audit	10
Subcallosal haemorrhage as a sign of diffuse axonal injury in patients with traumatic brain injury	10
Imaging spectrum of extracranial arterial vascular pathology: pearls for the radiologist	10

Safety and technical success of diphenhydramine as an alternative local anaesthetic agent for radiology procedures	10
Hepatocellular carcinoma surveillance at a quaternary centre: an audit of adherence to EASL guidance	10
Ambulatory care in interventional radiology: a framework for radiology day-case	10
Comparison of COVID-19 disease severity and PE rates between Kent B1.1.7 lineage versus other lineages on CTPA	10
The impact of endoscopic ultrasound on the management and outcome of patients with oesophageal cancer: an update of a systematic review	10
Re: Ultrasound simulation training to meet the 2021 Royal College of Radiologists' curriculum for radiology trainees: South East London experience	10
Virtual special edition on interventional radiology	10
Predictive value of major adverse cardiac events by T2-mapping texture analysis of the myocardial remote zone in patients with acute myocardial infarction	10
Increased consistent reporting of FDG PET-CT in presurgical assessment of medically refractory temporal lobe epilepsy	10
Weight-based paediatric CT abdomen/pelvis dose audit	10
In and around the pineal gland: a neuroimaging review	10
RCR meetings	10
A simple and convenient model combining multiparametric MRI and clinical features to predict tumour-infiltrating lymphocytes in breast cancer	10
Association of CT findings with invasive subtypes and the new grading system of lung adenocarcinoma	10
RCR meetings	10
Undergraduate radiology in low- and middle-income countries (LMICs)	10
Role of diffusion-weighted MRI in differentiating between benign and malignant bone lesions: a prospective study	9
COVID-19-related intracranial imaging findings: a large single-centre experience	9
Multiparametric MRI-based radiomics nomogram for predicting malignant transformation of sinonasal inverted papilloma	9
Evaluation of learning and exposure in the undergraduate interventional radiology curriculum (ELIXIR)	9
A national cross-sectional survey investigating the use of endoscopic ultrasound in the diagnosis and treatment of oesophageal cancer in the UK	9
A clinical–radiological predictive model for solitary pulmonary nodules and the relationship between radiological features and pathological subtype	9
The “filling defect”: an appropriate radiological term or a fluoroscopic hangover?	9
Current and future best practice in imaging, staging, and response assessment for Non-Hodgkin's lymphomas: the Specialist Integrated Haematological Malignancy Imaging Reporting (SIHMIR) paradigm shift	9
Optimal size threshold for PIRADSv2 category 5 upgrade and its positive predictive value: is it predictive of “very high” likelihood of clinically-significant cancer?	9
A pilot study on preoperative vascular anatomy and clinical application in rectal cancer resection	9
White matter integrity assessment in spinocerebellar ataxia type 2 (SCA2) patients	9
Percutaneous cryoablation for desmoid fibromatosis: initial experience at a UK centre	9
Multimodality imaging in primary hyperparathyroidism	9
Prognostic value of cardiac magnetic resonance imaging feature tracking technology in patients with light chain amyloidosis	9
Diffusion-weighted imaging of the orbit	9
Low-dose three-dimensional CT angiography for the evaluation of posterolateral protrusion of the vertebral artery over the posterior arch of the atlas: a quantitative anatomical comparison study of th	9
Maximal diameters and mean computed tomography (CT) value of synchronous multiple pure ground-glass opacities in lung adenocarcinoma are smaller	8
CT and MRI features of extraocular muscle granular cell tumour: preliminary experience in eight cases	8
Response to Editorial: addressing inequalities in access to radiology services and the subsequent correspondence	8
MRI-based radiomics models for noninvasive evaluation of lymphovascular space invasion in cervical cancer: a systematic review and meta-analysis	8
COVID-19 CT pulmonary angiogram examinations and reported pulmonary embolism incidence: comparison between peak first wave and early second wave	8
Impact of superior hypogastric nerve block during uterine fibroid embolisation on pain scores, opioid requirements, and same-day discharge: a case–control study	8
Trans-oral ultrasound-guided biopsy for head and neck lesions: an alternative for lesions not amenable to standard percutaneous image-guided biopsy. Description of the technique and case series	8
Routine whole-body CT identifies clinically significant findings in patients supported with veno-venous extracorporeal membrane oxygenation	8
Muscular MRI and magnetic resonance neurography in spinal muscular atrophy	8
The value of a dual-energy spectral CT quantitative analysis technique in acute pancreatitis	8
The broken circle method: a novel technique that enhances detection of Hill–Sachs lesions on internal rotation shoulder radiographs	8
Technique and protocols for cardiothoracic time-resolved contrast-enhanced magnetic resonance angiography sequences: a systematic review	8
Re: peritumoural MRI radiomics signature of brain metastases can predict epidermal growth factor receptor mutation status in lung adenocarcinoma	8
Current status of the credential “mechanical thrombectomy for acute ischaemic stroke” sponsored by the Royal College of Radiologists. What factors are preventing approval of training for non-radiologi	8
Deep-learning reconstruction to improve image quality of myocardial dynamic CT perfusion: comparison with hybrid iterative reconstruction	8
Establishment of a non-invasive prediction model for the risk of oesophageal variceal bleeding using radiomics based on CT	8
RCR meetings	8
Arterial spin labelling qualitative assessment in paediatric patients with MRI-negative epilepsy	8
Re: gender representation within radiology conferences in the UK in 2021	8
Contents	8
Three-dimensional pseudo-continuous arterial spin-labelled perfusion imaging for diagnosing upper cervical lymph node metastasis in patients with nasopharyngeal carcinoma: a whole-node histogram analy	8
Nomogram predictive model for differentiation between renal oncocytoma and chromophobe renal cell carcinoma at multi-phasic CT: a retrospective study	8
The design and use of a simple device for the MRI assessment of changes in cardiovascular function by lower-body negative-pressure-simulated reduction of central blood volume	8
Alteration of anterior cruciate ligament orientation in knees with trochlear dysplasia: description of a novel angle on MRI	8
Brain structural and functional MRI alterations and their predictive value for the visual outcome at 3 years in clinically isolated optic neuritis	7
Texture analysis applied in T1 maps and extracellular volume obtained using cardiac MRI in the diagnosis of hypertrophic cardiomyopathy and hypertensive heart disease compared with normal controls	7
Diagnostic accuracy of a decision-support software for the detection of intracranial large-vessel occlusion in CT angiography	7
Making an accurate diagnosis of anterior mediastinal lesions: a proposal for a new diagnostic algorithm from the BTOG Thymic Malignancies Special Interest Group	7
Pulmonary transit time as a marker of diastolic dysfunction in Takotsubo syndrome	7
Parenchymal involvement on CT pulmonary angiography in SARS-CoV-2 Alpha variant infection and correlation of COVID-19 CT severity score with clinical disease severity and short-term prognosis in a UK	7
Accuracy of transvaginal ultrasound versus MRI in the PreOperative Diagnostics of low-grade Endometrial Cancer (PODEC) study: a prospective multicentre study	7
25 Years of day-case interventional radiology at King’s College Hospital, London: worth the effort	7
Monitoring mild cognitive impairment of workers exposed to occupational aluminium based on quantitative susceptibility mapping	7
Radiomics nomogram integrating intratumoural and peritumoural features to predict lymph node metastasis and prognosis in clinical stage IA non-small cell lung cancer: a two-centre study	7
A retrospective cohort study comparing a novel, spherical, resorbable particle against five established embolic agents for uterine fibroid embolisation	7
Imaging features of myxoid soft-tissue tumours	7
Contents	7
A multi-lesional analysis of diffuse idiopathic pulmonary neuroendocrine cell hyperplasia: a single-centre analysis	7
Feature pyramid network-based computer-aided detection and monitoring treatment response of brain metastases on contrast-enhanced MRI	7
Impact of COVID-19 on radiology training: Royal College of Radiologists Junior Radiologists Forum national survey	7
A multicentre review of the direct-access mammography programme in Ireland for women with breast pain	7
World Federation for Interventional Stroke Treatment (WIST) multispecialty training guidelines for endovascular stroke intervention: Time is brain! – Response to commentary by UKNG	7
Symptomatic pelvic venous insufficiency: a review of the current controversies in pathophysiology, diagnosis, and management	7
COVID-19 recovery: tackling the 2-week wait colorectal pathway backlog by optimising CT colonography utilisation	7
Evaluation of an accelerated 3D modulated flip-angle technique in refocused imaging with an extended echo-train sequence with compressed sensing for imaging of the knee: comparison with routine 2D MRI	7
Mammography-based radiomics analysis and imaging features for predicting the malignant risk of phyllodes tumours of the breast	7
The ins and outs of male breast and anterior chest wall lesions from childhood to adulthood	7
The role of contrast-enhanced mammography in the preoperative evaluation of invasive lobular carcinoma of the breast	7

Preoperative prediction of microvascular invasion and perineural invasion in pancreatic ductal adenocarcinoma with 18F-FDG PET/CT radiomics analysis	7
CT coronary angiography as an alternative imaging method to ascertain cardiac output and its correlation with echocardiography	7
Opportunities in cancer imaging: risk-adapted breast imaging in screening	7
Utility of synthetic MRI in predicting pathological complete response of various breast cancer subtypes prior to neoadjuvant chemotherapy	7
A bump in the night: a 15-year retrospective analysis of urgent inpatient and emergency CT reporting out of hours in a tertiary referral centre	7
The imperative of a radiology AI deployment registry and the potential of ChatGPT	7
Contents	6
Bolus tracked computed tomographic pulmonary angiography in the acute care setting: Is it still valid?	6
Diagnostic value and limitations of CT in detecting rib fractures and analysis of missed rib fractures: a study based on early CT and follow-up CT as the reference standard	6
Kidney function testing prior to contrast-enhanced CT: a comparative cost analysis of a personalised risk-stratified pathway versus a test all approach	6
Usefulness and accuracy of segmental adrenal venous sampling on localisation and functional diagnosis of various adrenal lesions in primary aldosteronism	6
RESOLVE-based radiomics in cervical cancer: improved image quality means better feature reproducibility?	6
CT features of acute COVID-19 and long-term follow-up	6
CT appearances of pleural infection: analysis of the Second Multi-centre Intra-pleural Sepsis Trial (MIST 2) cohort	6
Letter to the editor re: ultrasound as the first line investigation for midgut malrotation: a UK tertiary centre experience	6
Weeping sponge kidney: an unusual phenomenon that should be considered in cases of severe renal haemorrhage	6
MRI-based radiomics for the diagnosis of triple-negative breast cancer: a meta-analysis	6
Inter-equipment validation of PET-based radiomics for predicting EGFR mutation statuses in patients with non-small cell lung cancer	6
CT pulmonary angiography: optimising acute thoracic imaging by fixed-timing contrast medium delivery with a modified breathing instruction	6
Myocardial T1 mapping and extracellular volume quantification as novel biomarkers in risk stratification of patients with systemic sclerosis	6
Multimodality imaging appearance of intrapericardial paragangliomas	6
The postoperative chest in lung cancer	6
Comparative study of 3D-T2WI vs. 3D-T2-FLAIR MRI in displaying human meningeal lymphatics vessels	6
Endolymphatic sac tumour: exploring the role of CT and MRI features in the diagnosis of 22 cases	6
Radiological features of Rosai–Dorfman disease: case series and review of the literature	6
Diagnostic performance of diffusion-weighted imaging and intravoxel incoherent motion for renal lesions: a meta-analysis	6
Ultrasound simulation training to meet the 2021 Royal College of Radiologists' curriculum for radiology trainees: South East London experience	6
Direct puncture versus contralateral femoral artery approach for catheter-directed thrombolysis of occluded infra-inguinal arterial bypass grafts	6
Disturbed white matter integrity on diffusion tensor imaging in young children with epilepsy	6
RCR meetings	6
Discrimination between microcystic meningioma and atypical meningioma using whole-lesion apparent diffusion coefficient histogram analysis	6
Adrenal venous sampling in primary aldosteronism: lessons from over 600 single-operator procedures	6
Differentiating infected focal liver lesions from malignant mimickers: value of ultrasound-based radiomics	6
The top 100 most cited articles on artificial intelligence in radiology: a bibliometric analysis	6
Personalising sarcoma care using quantitative multimodality imaging for response assessment	6
Imaging features of the evolving patterns of metastatic prostate cancer	6
“Triple-low” radiation dose bronchial artery CT angiography before bronchial artery embolisation: a feasibility study	6
The feasibility of dual-energy CT to predict the probability of symptomatic intracerebral haemorrhage after successful mechanical thrombectomy	6
Comparison of contrast-enhanced ultrasonography and MRI results obtained by expert and novice radiologists indicating short-term response after transarterial chemoembolisation for hepatocellular carci	6
Differentiation of malignant from benign orbital tumours using dual-energy CT	5
Deep learning for predicting the risk of immune checkpoint inhibitor-related pneumonitis in lung cancer	5
Introduction to radiomics for a clinical audience	5
Multimodality imaging of extra-nodal lymphoma in the head and neck	5
A deep-learning model using enhanced chest CT images to predict PD-L1 expression in non-small-cell lung cancer patients	5
Clinical application of ultrashort echo-time MRI for lung pathologies in children	5
Augmenting lung cancer diagnosis on chest radiographs: positioning artificial intelligence to improve radiologist performance	5
Post-immunotherapy imaging in lung cancer	5
Lung parenchyma and structure visualisation in paediatric chest MRI: a comparison of different short and ultra-short echo time protocols	5
A Radiology (with AI) christmas carol: Past, present and Yet to come	5
Can perihaematomal radiomics features predict haematoma expansion?	5
Medical imaging call centre: a communication success story	5
Angiographic features of pulmonary arteriovenous malformations: a new imaging classification system, BRAND, to guide embolisation	5
Predictive value of epicardial adipose tissue volume for early detection of left ventricular dysfunction in patients suspected of coronary artery disease	5
Acute embolic stroke with large-vessel occlusion: does contact aspiration thrombectomy show superiority?	5
Exercise electrocardiogram combined with cadmium zinc tellurium (CZT) cardiac-dedicated single photon emission computed tomography (SPECT) predicts coronary artery disease	5
Dual-layer spectral detector CT: predicting the invasiveness of pure ground-glass adenocarcinoma	5
Letter to the Editor re: re: ultrasound as the first line investigation for midgut malrotation: a UK tertiary centre experience	5
Upper limb computed tomography (CT) angiography in the emergency department	5
Systemic vasculitides and the role of multitechnique imaging in the diagnosis	5
Cost effectiveness and the role of the National Institute of Health and Care Excellence (NICE) in interventional radiology	5
Contrast-enhanced ultrasound may be effective for the measurement of the free distal segment length of the internal carotid artery in carotid body tumours	5
The potential utility of abbreviated breast MRI (FAST MRI) as a tool for breast cancer screening: a systematic review and meta-analysis	5
CT-based radiomics nomogram for the preoperative prediction of microsatellite instability and clinical outcomes in colorectal cancer: a multicentre study	5
Cerebral CT angiography as an ancillary investigation in the diagnosis of death using neurological criteria: a new UK guideline	5
Improved diagnostic performance of susceptibility-weighted imaging with compressed sensing-sensitivity encoding and neuromelanin-sensitive MRI for Parkinson's disease and atypical Parkinsonism	5
Ultrasound-guided core-needle biopsy for peripheral pulmonary lesions: a systematic review and meta-analysis	5
A validation study of combined resection and ablation therapy for multiple hepatocellular carcinoma	5
Changes in brain susceptibility in Wilson’s disease patients: a quantitative susceptibility mapping study	5
Paediatric radiology training in the UK: a national trainee survey by the British Society of Paediatric Radiologists (BSPR)	5
Cost drivers in endovascular pulmonary embolism interventions	5
Expanding global health opportunities for UK-based interventional radiology trainees	5
Imaging of non-specific complaints of the arm, neck, and/or shoulder (CANS): role of the scalene muscles and piercing variants in neurogenic thoracic outlet syndrome	5
Y-shaped airway self-expanding covered metallic stent removal via the interventional technique	5
Determination of the diagnostic accuracy of peritoneal biopsy with an 18G cutting needle under ultrasonography guidance and the contribution of CT findings to diagnosis before biopsy (our 8-year clini	5
Mixed-reality hologram for diagnosis and surgical planning of double outlet of the right ventricle: a pilot study	5
Diagnostic accuracy of the jetting sign and a dilatation ratio of left renal vein in CT urography for detecting anterior nutcracker syndrome	4
A comparative study for the evaluation of CT-based conventional, radiomic, combined conventional and radiomic, and delta-radiomic features, and the prediction of the invasiveness of lung adenocarcinom	4
Image findings of anti-neutrophil cytoplasmic antibody-associated vasculitis involving the skull base	4
Safety and efficacy of irreversible electroporation treatment in hepatobiliary and pancreatic tumours: a single-centre experience	4
Impact of the COVID-19 pandemic on interventional radiology services across the world	4
Contents	4
Dynamic thiol–disulphide homeostasis as a biomarker for predicting the development of contrast medium-associated acute kidney injury in the endovascular treatment of peripheral arterial disease: shoul	4
Effect of a second-generation motion correction algorithm on image quality and measurement reproducibility of coronary CT angiography in patients with a myocardial bridge and mural coronary artery	4
Contents	4
Diagnostic and prognostic value of parameters of erector spinae in patients with uremic sarcopenia	4
Differentiating between normal and fetal growth restriction-complicated placentas: is T2∗ imaging imaging more accurate than conventional diffusion-weighted imaging?	4
Ultrasound evaluation of persistent cervical lymph nodes in young children	4
Special issue on imaging the post cancer-treatment chest: heralding a new definition of an “expert thoracic imager”?	4
Two-dimensional parametric parenchymal blood flow in transarterial chemoembolisation for hepatocellular carcinoma: perfusion change quantification and tumour response prediction at 3 months post-inter	4
Nomogram to predict haemorrhagic transformation after stroke thrombolysis: a combined brain imaging and clinical study	4
Splenic embolisation practices within the UK: a national survey	4
Imaging in paediatric blast injuries: musculoskeletal injuries in the Syrian Civil War	4
Contents	4
Re: Tumour markers and their utility in imaging of abdominal and pelvic malignancies	4
COVID-19: could CT provide the best population level biomarker? Incidental COVID-19 in major trauma patients suggests higher than predicted rates of infection in London	4