Clinical Biochemistry

Article	Citations
Reply to Letter to the Editor “The importance of SII and FIB-4 scores in predicting mortality in idiopathic pulmonary fibrosis patients”	114
Editorial Board	53
The pitfalls and significance of using ratios and calculated parameters in laboratory medicine	42
The significance of PCSK-9′s level and polymorphism in premature coronary artery disease: Relation to risk and severity	33
Interference and failure: The challenge of high-concentration IgM monoclonal protein in capillary zone electrophoresis	27
Serum levels of sonic hedgehog in patients with IgA nephropathy are closely associated with intrarenal arteriolar lesions	22
Relationship between analytical imprecision and coefficient of determination (R2) of the calibration curve	21
Comparison of laboratory results and pain perception in self-sampled capillary blood versus venous blood sampling: a systematic review and meta-analysis	21
The biological diagnosis of Alzheimer’s disease using blood-based biomarkers: a Canadian prospective	21
Measuring copeptin, a surrogate for vasopressin in patients with hypertension – Can it identify those who are volume Responsive?	21
Editorial Board	20
Erratum to “Detecting Siemens macrotroponin by a point of care high sensitivity troponin I assay: A first look” [Clin. Biochem. 143 (2026) 111119]	20
Reducing AST orders by reviewing test panels	20
A circRNA-based ceRNA network shows its diagnostic value in non-small-cell lung cancer	20
Editorial Board	20
Association of phospholipid transfer protein (PLTP) and the effect of genetic variant rs5072 on hypertriglyceridemia and atherogenic dyslipidemia in children and adolescents from Southeastern Mexico	20
Defining blood gas analysis stability limits across five sample types	19
Whole-exome sequencing reveals a novel frameshift mutation in a consanguineous family with a hereditary coagulation factor XII deficiency	19
Limited incremental value of growth differentiation factor 15 in the initial evaluation of low and intermediate risk acute chest pain patients	18
Evidence-based extension of reagent shelf-life beyond expiry using patient-based moving averages, westgard sigma rules, and CLSI EP25	18
Explainable artificial intelligence for LDL cholesterol prediction and classification	17
Association of the C-terminal 42-peptide fragment of alpha-1 antitrypsin with the severity of ARDS: A pilot study	17
Accuracy-based proficiency testing for estradiol measurements	17
Choosing wisely-directed HFE testing improves diagnostic yield and test utilization in hereditary hemochromatosis	16
Corrigendum to “Optimization and validation of the Kairos Amino Acid Kit for plasma amino acid monitoring in inherited metabolic disorder patients” [Clin. Biochem. 138 (2025) 110960]	16

Comparison of fecal calprotectin and pancreatic elastase assays based on proficiency testing results	15
Editorial Board	15
Assessment of accuracy, clinical validity, and analytical linearity in point-of-care glucose monitoring devices for diabetes mellitus: A systematic review and meta-analysis	14
The presence of white cell Jordan's anomaly in multiple Acyl-CoA dehydrogenase deficiency: A case report and implications for clinical practice	14
14–3-3 η ETA protein as a potential marker of joint damage in gout	14
Retraction notice to “Distributions of alcohol use biomarkers including ethanol, phosphatidylethanol, ethyl glucuronide and ethyl sulfate in clinical and forensic testing” [Clin. Biochem. 82 (2020) 85	13
Fibroblast growth factor 23-induced hypophosphatemia in a malignant phosphaturic mesenchymal tumor: presentation of a rare case	13
Evaluation of an adenosine deaminase (ADA) assay in serum, pleural, pericardial, peritoneal, and cerebrospinal fluids on the Roche cobas c501 analyzer	13
Treatment target achievement in patients with familial hypercholesterolemia: A real-world descriptive study	13
Evaluation of noninvasive prenatal screening for copy number variations among screening laboratories	13
Expression profile of microRNAs in patients with decompensated cirrhosis by small RNA deep sequencing	13
A novel fluorescent-labeled serum protein electrophoresis method for detection of monoclonal free light chains in serum	12
Plasma trimethylamine levels predict adverse cardiovascular events in sudden cardiac arrest Survivors: A prospective cohort study	12
A large-scale survey on the knowledge, attitude, and practice of patient-based real-time quality control in China	12
YKL-40 levels in cerebrospinal fluid serve as a diagnostic biomarker for post-neurosurgical bacterial meningitis in patients with stroke	12
A spreadsheet tool for designing statistical quality control programs based on patient risk parameters	12
Editorial Board	12
The impact of environmental factors on external and internal specimen transport	12
The case of a bloody mess – Bictegravir/emtricitabine/tenofovir alafenamide induced colitis	11
Analytical Performance Evaluation for Estradiol using Liquid Chromatography–Tandem Mass Spectrometry	11
Green laboratory practice: Top 2 environmental recommendations for clinical laboratories	11
Serum netrin-1 levels are high in Rheumatoid arthritis associated interstitial lung disease	11
Troponin I interference in an 18-year-old patient with bradycardia: a case study	11
Analytical performance comparing siemens whole blood point of care Atellica VTLi to the central laboratory plasma Atellica IM high-sensitivity cardiac troponin I assays	11
Validation and application of volumetric absorptive microsampling (VAMS) dried blood method for phenylalanine measurement in patients with phenylketonuria	11
Long term false positive hsTnI on Alinity I probably caused by macrotroponin complex: Case report	11
Dried blood spot reference intervals for 18 amino acids in a 1 to 6 years old pediatric cohort	11
Impact of the implementation of the Sampson-NIH equation for the calculation of LDL-C in a large community cohort of adult and pediatric patients in Ontario	11
Direct serum biomarkers of liver fibrosis in metabolic dysfunction-associated steatotic liver disease: A scoping review	11
Clinical significance of fecal Syndecan-2 gene methylation combined with blood tumor abnormal protein detection in the diagnosis of colorectal cancer and precancerous lesions	10
2024 CSCC / SQBC Joint AnnualConference	10
Vascular endothelial growth factor A, a potential non-invasive biomarker for metabolic dysfunction-associated steatotic liver disease progression	10
Reducing unnecessary free thyroid hormone testing by the reinforcement of a reflexive algorithm in an outpatient environment	10
Detecting Siemens macrotroponin by a point of care high sensitivity troponin I assay: A first look	10
Large viral meningoencephalitis CSF serologic panel lacks utility in clinical decisions and outcomes	10
Prognostic value of secretoneurin in chronic heart failure. Data from the GISSI-Heart Failure trial	10
Editorial Board	10
Biological testing during acute psychological stress: A hindrance or an opportunity?	10
Editorial Board	10
Improving the environmental impact paradox of clinical medical laboratories	10
Detection of 58 fentanyl analogs using ARK fentanyl II and Immunalysis fentanyl immunoassays	10
Impact of lot-to-lot variation in absolute neutrophil count measured by a point-of-care device in patients receiving clozapine treatment	9
Editorial Board	9
Using differential mobility spectrometry to improve the specificity of targeted measurements of 2,3-dinor 11β-Prostaglandin F2α	9
Amikacin therapeutic drug monitoring: Evaluation of therapy performance and analytical techniques in a developing country setting	9
Estimation formulas for ionized magnesium in critically ill children	9
Canadian guidance for diagnosis and management of acute hepatic porphyrias	9
Demonstration of equivocal anti-glomerular basement membrane antibody positivity as a non-specific reaction through multiple immunologic assays in a case of pediatric asymptomatic hematuria	9
Elevated urine norepinephrine levels and alcohol use: A relationship that should be not neglected	9
Huge discrepancy between serum immunoglobulin concentration and proteinemia due to heavy chain disease	9

Rethinking research funding through a sustainability Lens	9
Secretoneurin is not associated with cardiovascular events or mortality in patients treated with hemodialysis: A prospective multicenter cohort study	9
The CDKN2A/B rs10811661 polymorphism is associated with metabolic syndrome, insulin resistance, and lipid levels in individuals with obesity and impaired fasting glucose	9
Editorial Board	9
Change in cardiac troponin T to differentiate acute from chronic myocardial injury in the Emergency Department	9
Methods for determining clinical utility	9
Towards achieving the end of the HIV epidemic: Advances, challenges and scaling-up strategies	8
Carrier frequency and molecular basis of hemoglobinopathies among blood donors in eastern Morocco: Implications for blood donation and genetic diagnosis	8
Evaluation of three NT-proBNP assays for heart failure	8
Editorial Board	8
HER2 gene mutations and matrix biomarkers in breast cancer	8
In vivo and in vitro relationship between ionized magnesium and ionized calcium	8
A rebuttal to: A letter to editor entitled: “A panel (CA19-9, CEA and PIVKA-II) of serum markers for pancreatic cancer diagnosis”	8
Laboratory reflex testing strategy for the early identification of primary care patients with multiple myeloma	8
Repression of miR-146a in predicting poor treatment outcome in triple-negative breast cancer	8
Autoverification-based algorithms to detect preanalytical errors: Two examples	8
Less is more: minimum sample volume for the free phenytoin assay on the Roche Cobas c503 analyzer	8
Expression profile of long-noncoding RNAs MIR31HG, NKILA, and PACER in systemic lupus erythematosus patients	8
Biomarker profiling for infection diagnosis in emergency departments: A diagnostic study evaluating C-reactive protein, procalcitonin, Club Cell Protein 16, interleukin-6, chitinase-like protein, and	8
A tale of two variants: The first reported case of hemoglobin Rush and hemoglobin S in a compound heterozygote	8
Elevated level of platelet factor 4 in follicular fluid is associated with polycystic ovary syndrome	8
Biotinidase activity is affected by both seasonal temperature and filter collection cards	8
Freelite and Kloneus assays in free light chain measurements in patients with renal impairment	8
Plasma levels of bone morphogenic protein-4 are downregulated in elderly hypertensive patients with heart failure with preserved ejection fraction	7
Phenotyping and genotyping for the dihydropyrimidine dehydrogenase test in Italy: a precise diagnostic strategy to detect rare variants and improve drug administration	7
Construction of a multi-classified decision tree model for identifying malignant pleural effusion and tuberculous pleural effusion	7
The importance of SII and FIB-4 scores in predicting mortality in idiopathic pulmonary fibrosis patients	7
Serum human epididymis protein 4 is associated with disease severity in patients with IgA nephropathy	7
Innovations in infectious disease diagnostics	7
Qualitative and quantitative detection of SARS-CoV-2 antibodies from dried blood spots	7
Evaluation of Siemens Atellica AMH assay and comparison with Roche, Beckman and Ansh Labs	7
Public knowledge of SARS-CoV-2 serological and viral lineage laboratory testing and result interpretation: A GENCOV study cross-sectional survey	7
From analytical metrics to clinical impact: Rethinking sigma metrics in the era of EFLM-based specifications	7
Characterizing M-protein light chain glycosylation via mass spectrometry	7
Are discordant cTnI results detected in an analytical comparison clinically irrelevant?	7
A new assay falsely increases lactate dehydrogenase in plasma but not in serum	7
Editorial Board	7
Minimal mathematical model for glycation of albumin	7
Agreement of LC-MS assays for IGF-1 traceable to NIST and WHO standards permits harmonization of reference intervals between laboratories	7
Accuracy of determination of free light chains (Kappa and Lambda) in plasma and serum by Swedish laboratories as monitored by external quality assessment	7
Inflammatory markers and their association with preeclampsia among pregnant women: A systematic review and meta-analysis	7
Krebs von den Lungen-6 (KL-6) as a diagnostic marker for pulmonary fibrosis: A systematic review and meta-analysis	7
Serum extracellular vesicles with NSD1 and FBXO7 mRNA as novel biomarkers for gastric cancer	7
Bias in IGF-1 concentrations and interpretation across three different clinical laboratory assays	7
Methods of the ivota triAl of he Atellica VTLi point of care emergenc de artment high sensitivity troponin eval ation	7
Evaluation of an automated assay for eosinophil-derived neurotoxin in serum	7
WITHDRAWN: Multiple myeloma revealed by a pulmonary embolism, with more anodal migration of λ IgG in the β2 region on serum protein electrophoresis	7
Ethnicity and sex-specific 99th percentile upper reference limits of high-sensitivity cardiac troponin I among adults in Xinjiang, China	6
Primer Part 1 − Preparing a laboratory quality improvement project	6
Therapeutic drug monitoring of levetiracetam – Is dried blood spot sampling suitable?	6
MELAS a clinically and genetically heterogeneous syndrome	6
Establishing sustainable quality improvement in the clinical laboratory: Redesign of the total testing process and digital transformation of routine quality assurance activities	6
Lack of interference of metronidazole with Roche cobas c502 and c702 chemistry tests	6
Altered plasma levels of apixaban in major gastrointestinal tract surgery: A case report and review of the literature	6
Factors influencing creatine kinase-MM concentrations in newborns and implications for newborn screening for Duchenne muscular dystrophy	6
Advantages and application of a decision tree algorithm combined with the Harris-Boyd criterion in the construction of dynamic reference intervals for coagulation indicators during pregnancy	6
Advances in molecular infectious diseases testing in the time of COVID-19	6
Innovations in infectious disease testing: Leveraging COVID-19 pandemic technologies for the future	6
Dose optimization and target attainment of vancomycin in children	6
Investigating angiogenin/ribonuclease 5 as a diagnostic biomarker for bladder cancer: In-depth analysis from a systematic review and meta-analysis	6
Serial secretoneurin measurement and risk of ventricular arrhythmias and death in patients with left ventricular systolic dysfunction	6
Implementing minimal request intervals for laboratory tests: a utilization management study across eight hospitals in South Iran	6
The potential of anti-glutamic acid decarboxylase antibodies to support a diagnosis of autoimmune diabetes mellitus	6
Corrigendum to “The biological diagnosis of Alzheimer’s disease using blood-based biomarkers: A Canadian prospective” [Clin. Biochem. 139 (2025); pages 1–17 /110980]	6
KNG1 mutations (c.618 T > G and c.1165C > T) cause disruption of the Cys206-Cys218 disulfide bond and truncation of the D5 domain leading to hereditary high molecular weight kininogen deficiency	5
Editorial Board	5
Enhanced detection and Characterization of M-proteins in multiple myeloma patients using An Agilent AssayMAP Bravo liquid handling system coupled to an LC-QTOF	5
Long-term follow-up with a clinical decision support system based on laboratory reports to manage patients with biochemical recurrence after radical prostatectomy	5
Medical appropriateness and economics of nucleic acid amplification testing for infectious diseases	5
CA19-9, CEA and PIVKA-Ⅱ as a novel panel of serum markers for diagnosis of pancreatic cancer	5
Corrigendum to “Elevated level of platelet factor 4 in follicular fluid is associated with polycystic ovary syndrome” [Clin. Biochem. 140 (2025) 111009]	5
Corrigendum to “Biological variability of lipoprotein-associated phospholipase A2 activity in healthy individuals” [Clin. Biochem. 50 (2017) 347–349]	5
The biological diagnosis of Alzheimer’s disease using blood-based biomarkers: A Canadian prospective	5
The performance of Carbohydrate Antigen 125-Thomsen-nouveau and anti-Müllerian hormone combined with CA125, Human epididymis protein 4 and Risk of Malignancy Algorithm in diagnosis for patients with E	5
Selected abstracts presented at the annual conference of the Canadian Society of Clinical Chemists (CSCC), 2023	5
Functional characterization of the p.(Gln195His) or Tainan and novel p.(Ser184Cys) or Toluca glucose-6-phosphate dehydrogenase (G6PD) gene natural variants identified through Mexican newborn screening	5
An improved and economical LLE-LC/MS method for quantifying phosphatidylethanol: Identification and separation of isotopic cross-talk in clinical alcohol testing	5
Cryoglobulinemia and Cryofibrinogenemia: Ten years of experience and diagnostic perspectives from a large laboratory-based cohort	5
Urine proteome uncovers common mechanisms between mucopolysaccharidosis types I and II	5
Clinical Labs: Working with planetary health for patient health	5

Clinically relevant urine creatinine underestimation in the low concentration range on the Siemens Dimension Vista®	5
Comparison of mean platelet component and mean platelet mass in immune thrombocytopenia versus hypoproductive thrombocytopenias	5
Kinetics of d-lactate and ischemia-modified albumin after abdominal aortic surgery and their ability to predict intestinal ischemia	5
Spirited away: Can ethanol testing in add-on orders provide meaningful results?	5
Phenotypic expression of the m.3243A > G variant not only depends on heteroplasmy or haplotype	5
Increased serum SGLT2 and its potential diagnostic and prognostic value in patients with acute ischemic stroke	5