Clinical Biochemistry

Article	Citations
Roles of matrix metalloproteinase-7 (MMP-7) in cancer	76
CRISPR-based tools: Alternative methods for the diagnosis of COVID-19	72
Are antioxidant enzymes essential markers in the diagnosis and monitoring of cancer patients – A review	71
Current use of bone turnover markers in the management of osteoporosis	44
Applications of machine learning in routine laboratory medicine: Current state and future directions	40
Genetic signature of CTLA-4, BTLA, TIM-3 and LAG-3 molecular expression in colorectal cancer patients: Implications in diagnosis and survival outcomes	26
Effects of fetuin-A with diverse functions and multiple mechanisms on human health	23
A novel, mitochondrial, internal tRNA-derived RNA fragment possesses clinical utility as a molecular prognostic biomarker in chronic lymphocytic leukemia	23
Staff rostering, split team arrangement, social distancing (physical distancing) and use of personal protective equipment to minimize risk of workplace transmission during the COVID-19 pandemic: A sim	22
High clinical performance and quantitative assessment of antibody kinetics using a dual recognition assay for the detection of SARS-CoV-2 IgM and IgG antibodies	22
The role of Monocyte Distribution Width (MDW) in the prognosis and monitoring of COVID-19 patients	21
Early prediction of COVID-19-associated acute kidney injury: Are serum NGAL and serum Cystatin C levels better than serum creatinine?	21
Validating the NIH LDL-C equation in a specialized lipid cohort: Does it add up?	20
Differences in biomarker concentrations and predictions of long-term outcome in patients with ST-elevation and non-ST-elevation myocardial infarction	19
Measuring magnesium – Physiological, clinical and analytical perspectives	18
Analytical and clinical validation of dried blood spot and volumetric absorptive microsampling for measurement of tacrolimus and creatinine after renal transplantation	18
Increased oxidative stress and inflammatory markers contrasting with the activation of the cholinergic anti-inflammatory pathway in patients with metabolic syndrome	18
Initial determination of COVID-19 seroprevalence among outpatients and healthcare workers in Minnesota using a novel SARS-CoV-2 total antibody ELISA	17
Serum exosomal hsa_circ_0069313 has a potential to diagnose more aggressive non-small cell lung cancer	17
The use of aptamers in prostate cancer: A systematic review of theranostic applications	17
Quality assurance practices for point of care testing programs: Recommendations by the Canadian society of clinical chemists point of care testing interest group	17
Simultaneous quantification of plasma levels of 12 antimicrobial agents including carbapenem, anti-methicillin-resistant Staphylococcus aureus agent, quinolone and azole used in intensive care unit us	16
Using high sensitivity cardiac troponin values in patients with SARS-CoV-2 infection (COVID-19): The Padova experience	16
Interest of blood biomarkers to predict lesions in medical imaging in the context of mild traumatic brain injury	16
Laboratory biomarkers of Multiple Sclerosis (MS)	15

Internal quality control: Moving average algorithms outperform Westgard rules	15
Measuring the contribution of Lp(a) cholesterol towards LDL-C interpretation	15
New prognostic markers in pulmonary arterial hypertension: CRP to albumin ratio and uric acid	14
Antioxidants other than vitamin C may be detected by glucose meters: Immediate relevance for patients with disorders targeted by antioxidant therapies	14
Hyperphosphatemia rather than hypophosphatemia indicates a poor prognosis in patients with sepsis	14
Single-nucleotide polymorphisms (SNPs) of antioxidant enzymes SOD2 and GSTP1 genes and SLE risk and severity in an Egyptian pediatric population	14
Canadian society of clinical chemists (CSCC) interim consensus guidance for testing and reporting of SARS-CoV-2 serology	14
Change in troponin concentrations in patients with macrotroponin: An in vitro mixing study	14
Integrating quality control and external quality assurance	14
Simultaneous quantification of rituximab and eculizumab in human plasma by liquid chromatography-tandem mass spectrometry and comparison with rituximab ELISA kits	14
Performance of conventional histopathology and GeneXpert MTB/RIF in the diagnosis of spinal tuberculosis from bone specimens: A prospective clinical study	14
A point-of-need platform for rapid measurement of a host-protein score that differentiates bacterial from viral infection: Analytical evaluation	14
Validation and comparison of five data mining algorithms using big data from clinical laboratories to establish reference intervals of thyroid hormones for older adults	13
Sfrp5/Wnt5a and leptin/adiponectin levels in the serum and the periarterial adipose tissue of patients with peripheral arterial occlusive disease	13
TSH continuous reference intervals by indirect methods: A Comparisons to Partitioned Reference Intervals	13
Diagnostic performance of a rapid, novel, whole blood, point of care high-sensitivity cardiac troponin I assay for myocardial infarction	13
Chemotherapy-associated clonal hematopoiesis mutations should be taken seriously in plasma cell-free DNA KRAS/NRAS/BRAF genotyping for metastatic colorectal cancer	13
Urine toxicology screening by liquid chromatography time-of-flight mass spectrometry in a quaternary hospital setting	13
Considerations for understanding protein measurements: Identification of formation, degradation and more pathological relevant epitopes	13
Donor-specific ELISPOT assay for predicting acute rejection and allograft function after kidney transplantation: A systematic review and meta-analysis	12
Creatine kinase test diagnostic accuracy in neonatal screening for Duchenne Muscular Dystrophy: A systematic review	12
Clearing drug interferences in myeloma treatment using mass spectrometry	12
A focus on the roles of histones in health and diseases	12
Novel microRNA biomarkers of systemic lupus erythematosus in plasma: miR-124-3p and miR-377-3p	12
A 3-min UPLC-MS/MS method for the simultaneous determination of plasma catecholamines and their metabolites: Method verification and diagnostic efficiency	12
Aspirin: Bitter pill or miracle drug?	12
The potential value of the neutrophil to lymphocyte ratio for early differential diagnosis and prognosis assessment in patients with aortic dissection	11
Monitoring intracellular tacrolimus concentrations and its relationship with rejection in the early phase after renal transplantation	11
Storage conditions, sample integrity, interferences, and a decision tool for investigating unusual high-sensitivity cardiac troponin results	11
Anti-SARS-CoV-2 IgM improves clinical sensitivity early in disease course	11
Preparation, stability and commutability of candidate reference materials for lactate dehydrogenase (LDH)	11
Erythrocyte reduced/oxidized glutathione and serum thiol/disulfide homeostasis in patients with rheumatoid arthritis	11
Screening and confirmation methods for the qualitative identification of nine phytocannabinoids in urine by LC-MS/MS	11
Comparison of 8 methods for univariate statistical exclusion of pathological subpopulations for indirect reference intervals and biological variation studies	11
Effect of sample size and the traditional parametric, nonparametric, and robust methods on the establishment of reference intervals: Evidence from real world data	10
Innovations in infectious disease testing: Leveraging COVID-19 pandemic technologies for the future	10
Alu cell-free DNA concentration, Alu index, and LINE-1 hypomethylation as a cancer predictor	10
Association of vitamin D receptor genetic variants with bone mineral density and inflammatory markers in rheumatoid arthritis	10
Continuous reference intervals for 21 biochemical and hematological analytes in healthy Chinese children and adolescents: The PRINCE study	10
Comparison of capillary and venous blood sampling for routine coagulation assays	10
Detection of glucosylsphingosine in dried blood spots for diagnosis of Gaucher disease by LC-MS/MS	10
A comparison of SARS-CoV-2 nucleocapsid and spike antibody detection using three commercially available automated immunoassays	10
Serum free light chain reference intervals in an Optilite and their influence on clinical guidelines	10
Differential associations of cardiac troponin T and cardiac troponin I with coronary artery pathology and dynamics in response to short-duration exercise	9
Polymorphisms of interleukin 4 and interleukin 4 receptor genes and bronchial asthma risk among Egyptian children	9
Developing an evidence-based approach to quality control	9
NUDT15: A bench to bedside success story	9
Clinical laboratory characteristics of patients with obstructive jaundice accompanied by dyslipidemia	9
Association between circulating asprosin levels and carotid atherosclerotic plaque in patients with type 2 diabetes	9
Orexin-A measurement in narcolepsy: A stability study and a comparison of LC-MS/MS and immunoassays	9

Validation of COVID-19 serologic tests and large scale screening of asymptomatic healthcare workers	9
Data mining: Biological and temporal factors associated with blood parathyroid hormone, vitamin D, and calcium concentrations in the Southwestern Chinese population	9
Thyroid panel reference intervals in healthy children and adolescents: A Spanish cohort	9
IL-23 and IL-17 in acute ischemic stroke: Correlation with stroke scales and prognostic value	8
Long non-coding RNA LINC01793 as a potential diagnostic biomarker of hepatitis B virus-related hepatocellular carcinoma	8
SIRT2 and SIRT3 expression correlates with redox imbalance and advanced clinical stage in patients with multiple myeloma	8
The potential value of Copeptin and Pentraxin3 for evaluating the severity of coronary stenosis in patients with coronary artery disease	8
Cardiac troponin I measured with a very high sensitivity assay predicts subclinical carotid atherosclerosis: The Akershus Cardiac Examination 1950 Study	8
Ski: Double roles in cancers	8
Statistical methods used in the estimation of age-specific paediatric reference intervals for laboratory blood tests: A systematic review	8
Biotinidase activity is affected by both seasonal temperature and filter collection cards	8
A model to establish autoverification in the clinical laboratory	8
Interim analysis of the clinical performance of five SARS-Cov-2 serology assays	8
Evaluation of the Visby medical COVID-19 point of care nucleic acid amplification test	8
Evaluation of SARS-CoV-2 prototype serologic test in hospitalized patients	8
Qualitative and quantitative detection of SARS-CoV-2 antibodies from dried blood spots	8
Serum oncostatin M is a potential biomarker of disease activity and infliximab response in inflammatory bowel disease measured by chemiluminescence immunoassay	8
Serum levels of 4-hydroxynonenal adducts and responding autoantibodies correlate with the pathogenesis from hyperglycemia to Alzheimer’s disease	8
Determination of clinically acceptable cut-offs for hemolysis index: An application of bootstrap method using real-world data	8
The microRNA-485-3p concentration in salivary exosome-enriched extracellular vesicles is related to amyloid β deposition in the brain of patients with Alzheimer’s disease	8
Comparison of the Friedewald equation with Martin and Sampson equations for estimating LDL cholesterol in hypertriglyceridemic adults	8
Multiplex assessment of SARS-CoV-2 antibodies improves assay sensitivity and correlation with neutralizing antibodies	8
Lysosomal storage disorders: Novel and frequent pathogenic variants in a large cohort of Indian patients of Pompe, Fabry, Gaucher and Hurler disease	8
Uncommon antinuclear antibody patterns as diagnostic indicators	7
Branched chain amino acids are associated with metabolic complications in liver transplant recipients	7
Methods for analyzing positive cardiac troponin assay interference	7
The importance of neopterin in COVID-19: The prognostic value and relation with the disease severity	7
Serologically assessed heat shock protein 47 is related to fibrosis stage in early compensated alcohol-related liver disease	7
Age specific reference intervals for plasma biomarkers of neurodegeneration and neurotrauma in a Canadian population	7
MALDI-TOF mass spectrometry can distinguish immunofixation bands of the same isotype as monoclonal or biclonal proteins	7
Updated ferritin reference intervals for the Roche Elecsys® immunoassay	7
Serum amyloid A1 can be a novel biomarker for evaluating the presence and severity of acute coronary syndrome	7
Anti-phosphatidylserine/prothrombin complex antibodies (aPS/PT) increase the risk for thrombosis based on lupus anticoagulant positivity	7
Serial cardiac biomarkers for risk stratification of patients with COVID-19	7
Evaluation of Abbott ID NOW COVID-19 POC test performance characteristics and integration in the regional health network workflows to improve health care delivery	7
The clinical role of combined serum C1q and hsCRP in predicting coronary artery disease	7
Six novel variants in the PKLR gene associated with pyruvate kinase deficiency in Argentinian patients	7
Hydroxocobalamin interference in routine laboratory tests: Development of a protocol for identifying samples and reporting results from patients treated with CyanokitTM	7
High-sensitivity cardiac troponin T and N-terminal pro-B-type natriuretic peptide in acute heart failure: Data from the ACE 2 study	7
Glucose-6-phosphate dehydrogenase deficiency and SARS-CoV-2 mortality: Is there a link and what should we do?	6
High-throughput simultaneous quantification of five azole anti-fungal agents and one active metabolite in human plasma using ultra-high-performance liquid chromatography coupled to tandem mass spectro	6
Comparing the diagnostic value of serum oligosaccharide chain (G-test) and alpha-fetoprotein for hepatitis B virus-related liver cancer	6
Biological variation of secretoneurin; a novel cardiovascular biomarker implicated in arrhythmogenesis	6
Longitudinal assessment of leukotriene B4, lipoxin A4, and resolvin D1 plasma levels in pregnant women with risk factors for preeclampsia	6
No increase in the incidence of cardiac troponin I concentration above the 99th percentile by Siemens Centaur high-sensitivity compared to the contemporary assay	6
The development and validation of a high-capacity serological assay for celiac disease	6
Performance of saliva compared with nasopharyngeal swab for diagnosis of COVID-19 by NAAT in cross-sectional studies: Systematic review and meta-analysis	6
Reference intervals for plasma β-CTX and P1NP in children: A systematic review and pooled estimates	6
Analytical and clinical performance of cPass neutralizing antibodies assay	6
The impact of diagnostic stewardship interventions on Clostridiodes difficile test ordering practices and results	6
Sample stability of autoantibodies: A tool for laboratory quality initiatives	6
Use of a Lean Six Sigma approach to investigate excessive quality control (QC) material use and resulting costs	6
Diagnostic performance and predictive value of D-dimer testing in patients referred to the emergency department for suspected myocardial infarction	6
Bias in IGF-1 concentrations and interpretation across three different clinical laboratory assays	6
Circulating miR-143 and miR-145 as promising biomarkers for evaluating severity of coronary artery stenosis in patients with acute coronary syndrome	6
Evaluation of the Tasso-SST® capillary blood microsampling device for the measurement of endogenous uracil levels	6
A novel 15.8 kb deletion α-thalassemia confirmed by long-read single-molecule real-time sequencing: Hematological phenotypes and molecular characterization	6
Continuous reference intervals for 19 endocrine, fertility, and immunochemical markers in the CALIPER cohort of healthy children and adolescents	6
Analytical characterization of the SARS-CoV-2 EURM-017 reference material	6
Serum arachidonic acid levels is a predictor of poor functional outcome in acute intracerebral hemorrhage	6
Age- and ethnicity-related reference intervals for serum vitamin B12	6
Biomarkers in the prognostic evaluation of ischemic stroke: Is there benefit in the measurements of TREM-1 and TREM-2 in the acute phase?	6
Staged reflexive artificial intelligence driven testing algorithms for early diagnosis of pituitary disorders	5
External validation of the clinical chemistry score	5
Application of a six sigma model to the evaluation of the analytical performance of serum enzyme assays and the design of a quality control strategy for these assays: A multicentre study	5
Comparison of the difference in serum insulin growth factor-1 levels between chronological age and bone age among children	5
Novel SERPINC1 missense mutation (Cys462Tyr) causes disruption of the 279Cys-462Cys disulfide bond and leads to type Ⅰ hereditary antithrombin deficiency	5
The impact of environmental factors on external and internal specimen transport	5
Age affects the diagnostic accuracy of serum N-terminal pro-B-type natriuretic peptide for heart failure in patients with pleural effusion	5
Anti-NR2 glutamate receptor antibodies as an early biomarker of cerebral small vessel disease	5
Application and utility of boosting machine learning model based on laboratory test in the differential diagnosis of non-COVID-19 pneumonia and COVID-19	5
Clinical efficacy of thyroid-stimulating immunoglobulin detection for diagnosing Graves’ disease and predictors of responsiveness to methimazole	5
Comparison of glomerular filtration rate estimating formulas among Japanese adults without kidney disease	5
Prognostic value of circulating microRNAs compared to high-sensitivity troponin T in patients presenting with suspected acute coronary syndrome to the emergency department	5
Biochemistry tests in hospitalized COVID-19 patients: Experience from a Canadian tertiary care centre	5
The utility HBA1c test as a screening biomarker for detecting gestational diabetes mellitus	5
A review of temperature-related challenges and solutions for the Abbott i-STAT and Siemens Healthineers epoc devices	5
Using the hemolysis index of Abbott’s Alinity c for the measurement of plasma free hemoglobin in ECMO patients	5
Characterizing M-protein light chain glycosylation via mass spectrometry	5
Using quantitative immunoprecipitation mass spectrometry (QIP-MS) to identify low level monoclonal proteins	5

Predicting the disaster – The role of CRP in acetabular surgery	5
Evaluation of BD Barricor™ and PST™ blood collection tubes compared to serum for testing 11 therapeutic drugs on a Roche Cobas® 8000 platform	5
Evaluation of the CKD-EPI 2021 creatinine equation using laboratory data: Considerations for practice changes among clinical laboratories in British Columbia, Canada	5
Setting minimum clinical performance specifications for tests based on disease prevalence and minimum acceptable positive and negative predictive values: Practical considerations applied to COVID-19 t	5
Pediatric reference intervals for 32 routine biochemical markers using the siemens healthineers atellica® CH assays in healthy children and adolescents	5
Defining blood gas analysis stability limits across five sample types	5
Salivary antibodies are detected with a commercial anti-SARS-CoV-2 assay only after two doses of vaccine using serum thresholds	5
Identification of a novel 10.3 kb deletion causing α0-thalassemia by third-generation sequencing: Pedigree analysis and genetic diagnosis	5
Novel mutations associated with carnitine-acylcarnitine translocase and carnitine palmitoyl transferase 2 deficiencies in Malaysia	5
Prognostic value of soluble urokinase plasminogen activator receptor in patients presenting to the emergency department with chest pain suggestive of acute coronary syndrome	5
Multirule procedures vs moving average algorithms for IQC: An appropriate comparison reveals how best to combine their strengths	5
Current status of therapeutic drug monitoring for methotrexate, imatinib, paclitaxel in China	5
Evaluation of sporadic bovine alkaline phosphatase interference in the Beckman Access unconjugated estriol (uE3) assay affecting maternal serum screening results	5
Validation of plasma amino acid profile using UHPLC-mass spectrometer (QDa) as a screening method in a metabolic disorders reference centre: Performance and accreditation concerns	5
Advances in molecular infectious diseases testing in the time of COVID-19	5
The 10 most frequently requested blood tests in the Capital Region of Denmark, 2010–2019 and simulated effect of minimal retesting intervals	5
Artificial intelligence: A step forward in the clinical laboratory, a decision maker hub	5
Rapid detection of twenty-nine common Chinese glucose-6-phosphate dehydrogenase variants using a matrix-assisted laser desorption/ionization-time of flight mass spectrometry assay on dried blood spots	5
The analytical performance of six urine drug screens on cobas 6000 and ARCHITECT i2000 compared to LC-MS/MS gold standard	5
Oral glucose tolerance test to diagnose gestational diabetes mellitus: Impact of variations in specimen handling	5
More attention should be paid to pregnant women who fail non-invasive prenatal screening	5
The use of freeze-dried blood samples affects the results of a dried blood spot analysis	5