Clinical Biochemistry

Article	Citations
Comparison of two (data mining) indirect approaches for between-subject biological variation determination	92
Hydroxocobalamin does not interfere with high-sensitivity cardiac troponin T assay	82
Editorial Board	75
The significance of PCSK-9′s level and polymorphism in premature coronary artery disease: Relation to risk and severity	66
The pitfalls and significance of using ratios and calculated parameters in laboratory medicine	29
Reply to Letter to the Editor “The importance of SII and FIB-4 scores in predicting mortality in idiopathic pulmonary fibrosis patients”	26
IL-23 and IL-17 in acute ischemic stroke: Correlation with stroke scales and prognostic value	23
External validation of the clinical chemistry score	23
Serum levels of sonic hedgehog in patients with IgA nephropathy are closely associated with intrarenal arteriolar lesions	22
Measuring copeptin, a surrogate for vasopressin in patients with hypertension – Can it identify those who are volume Responsive?	21
Establishing age-stratified red blood cell fatty acid reference ranges using model-based clustering and iterative application of the harris-boyd method	21
Biomarkers in the prognostic evaluation of ischemic stroke: Is there benefit in the measurements of TREM-1 and TREM-2 in the acute phase?	21
Clinical efficacy of thyroid-stimulating immunoglobulin detection for diagnosing Graves’ disease and predictors of responsiveness to methimazole	20
A circRNA-based ceRNA network shows its diagnostic value in non-small-cell lung cancer	20
Relationship between analytical imprecision and coefficient of determination (R2) of the calibration curve	20
Whole-exome sequencing reveals a novel frameshift mutation in a consanguineous family with a hereditary coagulation factor XII deficiency	19
Editorial Board	19
Editorial Board	19
Association of the C-terminal 42-peptide fragment of alpha-1 antitrypsin with the severity of ARDS: A pilot study	18
Reducing AST orders by reviewing test panels	18
Accuracy-based proficiency testing for estradiol measurements	18
Integrating quality control and external quality assurance	16
Comparison of 8 methods for univariate statistical exclusion of pathological subpopulations for indirect reference intervals and biological variation studies	16
Novel threshold value of midnight serum cortisol for diagnosis of hypercortisolism using the Roche Cortisol II assay	15
Association of phospholipid transfer protein (PLTP) and the effect of genetic variant rs5072 on hypertriglyceridemia and atherogenic dyslipidemia in children and adolescents from Southeastern Mexico	15

Creatine kinase test diagnostic accuracy in neonatal screening for Duchenne Muscular Dystrophy: A systematic review	15
Defining blood gas analysis stability limits across five sample types	15
Explainable artificial intelligence for LDL cholesterol prediction and classification	15
Canadian Society of Clinical Chemists (CSCC) consensus guidance for testing, selection and quality management of SARS-CoV-2 point-of-care tests	15
A spreadsheet tool for designing statistical quality control programs based on patient risk parameters	14
High sensitivity troponin, analytical advantages, clinical benefits and clinical challenges – An update	14
Artificial intelligence: A step forward in the clinical laboratory, a decision maker hub	14
Editorial Board	13
Editorial Board	13
The presence of white cell Jordan's anomaly in multiple Acyl-CoA dehydrogenase deficiency: A case report and implications for clinical practice	13
Editorial Board	13
Treatment target achievement in patients with familial hypercholesterolemia: A real-world descriptive study	13
Retraction notice to “Distributions of alcohol use biomarkers including ethanol, phosphatidylethanol, ethyl glucuronide and ethyl sulfate in clinical and forensic testing” [Clin. Biochem. 82 (2020) 85	13
Editorial Board	13
Is the diagnostic rate for the common subtypes of A1AT deficiency consistent across two Canadian Provinces?	13
NT-proBNP in young healthy adults undergoing non-cardiac surgery	12
Reference intervals for preterm thyroid function during the fifth to seventh day of life	12
Urine toxicology screening by liquid chromatography time-of-flight mass spectrometry in a quaternary hospital setting	12
Comparison of fecal calprotectin and pancreatic elastase assays based on proficiency testing results	12
Evaluation of noninvasive prenatal screening for copy number variations among screening laboratories	11
Paraoxonase 2 C311S single nucleotide polymorphism is associated with type C lesions in coronary atherosclerosis	11
Expression profile of microRNAs in patients with decompensated cirrhosis by small RNA deep sequencing	11
The impact of environmental factors on external and internal specimen transport	11
14–3-3 η ETA protein as a potential marker of joint damage in gout	11
Evaluation of an adenosine deaminase (ADA) assay in serum, pleural, pericardial, peritoneal, and cerebrospinal fluids on the Roche cobas c501 analyzer	11
Analytical Performance Evaluation for Estradiol using Liquid Chromatography–Tandem Mass Spectrometry	10
Editorial Board	10
YKL-40 levels in cerebrospinal fluid serve as a diagnostic biomarker for post-neurosurgical bacterial meningitis in patients with stroke	10
Combination of antibody tests against SARS-CoV-2 for health care workers after vaccination	10
Biological testing during acute psychological stress: A hindrance or an opportunity?	10
Clinical significance of fecal Syndecan-2 gene methylation combined with blood tumor abnormal protein detection in the diagnosis of colorectal cancer and precancerous lesions	10
Automatic reflex addition of serum magnesium determination to samples with severe hypocalcemia is an effective tool to detect and treat hypomagnesemia	10
Reply to Letter to Editor Diagnostic significance of uncommon antinuclear antibodies	10
Serum netrin-1 levels are high in Rheumatoid arthritis associated interstitial lung disease	10
Editorial Board	10
Analytical performance comparing siemens whole blood point of care Atellica VTLi to the central laboratory plasma Atellica IM high-sensitivity cardiac troponin I assays	9
Large viral meningoencephalitis CSF serologic panel lacks utility in clinical decisions and outcomes	9
Long term false positive hsTnI on Alinity I probably caused by macrotroponin complex: Case report	9
External quality assessment in the absence of proficiency testing: A split-sample testing program experience	9
Detection of 58 fentanyl analogs using ARK fentanyl II and Immunalysis fentanyl immunoassays	9
Editorial Board	9
Validation and application of volumetric absorptive microsampling (VAMS) dried blood method for phenylalanine measurement in patients with phenylketonuria	9
Screening and confirmation methods for the qualitative identification of nine phytocannabinoids in urine by LC-MS/MS	9
Evaluation of fecal SYPL1 as a diagnostic biomarker in colorectal cancer	9
Dried blood spot reference intervals for 18 amino acids in a 1 to 6 years old pediatric cohort	9
Staged reflexive artificial intelligence driven testing algorithms for early diagnosis of pituitary disorders	9
Serum biotin interference: A troublemaker in hormone immunoassays	9
Biological variation of secretoneurin; a novel cardiovascular biomarker implicated in arrhythmogenesis	9
Laboratory reporting of framingham risk score increases statin prescriptions in at-risk patients	9
2024 CSCC / SQBC Joint AnnualConference	8

Using differential mobility spectrometry to improve the specificity of targeted measurements of 2,3-dinor 11β-Prostaglandin F2α	8
Editorial Board	8
Laboratory reflex testing strategy for the early identification of primary care patients with multiple myeloma	8
Clinical concordance assessment should be an integral component of laboratory method comparison studies: A regression transference of routine clinical data approach	8
Demonstration of equivocal anti-glomerular basement membrane antibody positivity as a non-specific reaction through multiple immunologic assays in a case of pediatric asymptomatic hematuria	8
Hempseed (Cannabis sativa) offers effective alternative over statins in ameliorating hypercholesterolemia associated nephropathy	8
Methods for determining clinical utility	8
Validating the NIH LDL-C equation in a specialized lipid cohort: Does it add up?	8
Secretoneurin is not associated with cardiovascular events or mortality in patients treated with hemodialysis: A prospective multicenter cohort study	8
Elevated urine norepinephrine levels and alcohol use: A relationship that should be not neglected	8
Pediatric ionized calcium reference intervals from archived radiometer data	8
Using quantitative immunoprecipitation mass spectrometry (QIP-MS) to identify low level monoclonal proteins	8
Amikacin therapeutic drug monitoring: Evaluation of therapy performance and analytical techniques in a developing country setting	8
Prognostic value of secretoneurin in chronic heart failure. Data from the GISSI-Heart Failure trial	8
Current status of therapeutic drug monitoring for methotrexate, imatinib, paclitaxel in China	8
Editorial Board	8
Huge discrepancy between serum immunoglobulin concentration and proteinemia due to heavy chain disease	8
Canadian guidance for diagnosis and management of acute hepatic porphyrias	8
Diagnostic significance of uncommon antinuclear antibodies	7
Repression of miR-146a in predicting poor treatment outcome in triple-negative breast cancer	7
Mid-regional pro-atrial natriuretic peptide levels before and after hemodialysis predict long-term prognosis	7
Serum human epididymis protein 4 is associated with disease severity in patients with IgA nephropathy	7
Krebs von den Lungen-6 (KL-6) as a diagnostic marker for pulmonary fibrosis: A systematic review and meta-analysis	7
Donor-specific ELISPOT assay for predicting acute rejection and allograft function after kidney transplantation: A systematic review and meta-analysis	7
Carrier frequency and molecular basis of hemoglobinopathies among blood donors in eastern Morocco: Implications for blood donation and genetic diagnosis	7
In vivo and in vitro relationship between ionized magnesium and ionized calcium	7
Expression profile of long-noncoding RNAs MIR31HG, NKILA, and PACER in systemic lupus erythematosus patients	7
Are discordant cTnI results detected in an analytical comparison clinically irrelevant?	7
Towards achieving the end of the HIV epidemic: Advances, challenges and scaling-up strategies	7
Detection of Vitamin D Metabolites in Breast Milk: Perspectives and challenges for measurement by Liquid Chromatography Tandem-Mass Spectrometry	7
Autoverification-based algorithms to detect preanalytical errors: Two examples	7
Freelite and Kloneus assays in free light chain measurements in patients with renal impairment	7
Novel mutations associated with carnitine-acylcarnitine translocase and carnitine palmitoyl transferase 2 deficiencies in Malaysia	7
The importance of SII and FIB-4 scores in predicting mortality in idiopathic pulmonary fibrosis patients	6
Biotinidase activity is affected by both seasonal temperature and filter collection cards	6
Construction of a multi-classified decision tree model for identifying malignant pleural effusion and tuberculous pleural effusion	6
A new assay falsely increases lactate dehydrogenase in plasma but not in serum	6
Diagnostic performance of a rapid, novel, whole blood, point of care high-sensitivity cardiac troponin I assay for myocardial infarction	6
Methods of the ivota triAl of he Atellica VTLi point of care emergenc de artment high sensitivity troponin eval ation	6
Plasma levels of bone morphogenic protein-4 are downregulated in elderly hypertensive patients with heart failure with preserved ejection fraction	6
Agreement of LC-MS assays for IGF-1 traceable to NIST and WHO standards permits harmonization of reference intervals between laboratories	6
Editorial Board	6
Serum levels of 4-hydroxynonenal adducts and responding autoantibodies correlate with the pathogenesis from hyperglycemia to Alzheimer’s disease	6
Characterizing M-protein light chain glycosylation via mass spectrometry	6
Evaluation of an automated assay for eosinophil-derived neurotoxin in serum	6
The potential of anti-glutamic acid decarboxylase antibodies to support a diagnosis of autoimmune diabetes mellitus	6
Minimal mathematical model for glycation of albumin	6
Public knowledge of SARS-CoV-2 serological and viral lineage laboratory testing and result interpretation: A GENCOV study cross-sectional survey	6
Accuracy of determination of free light chains (Kappa and Lambda) in plasma and serum by Swedish laboratories as monitored by external quality assessment	6
Clinical chemistry score misses fewer deaths as compared to troponin T alone in a United States emergency department population	6
Serum extracellular vesicles with NSD1 and FBXO7 mRNA as novel biomarkers for gastric cancer	6
Bias in IGF-1 concentrations and interpretation across three different clinical laboratory assays	6
Inflammatory markers and their association with preeclampsia among pregnant women: A systematic review and meta-analysis	6
The analytical performance of six urine drug screens on cobas 6000 and ARCHITECT i2000 compared to LC-MS/MS gold standard	6
Innovations in infectious disease diagnostics	6
Qualitative and quantitative detection of SARS-CoV-2 antibodies from dried blood spots	6
Evaluation of Siemens Atellica AMH assay and comparison with Roche, Beckman and Ansh Labs	6
Kinetics of d-lactate and ischemia-modified albumin after abdominal aortic surgery and their ability to predict intestinal ischemia	5
Antioxidants other than vitamin C may be detected by glucose meters: Immediate relevance for patients with disorders targeted by antioxidant therapies	5
Rapid COVID-19 testing: Speed, quality and cost. Can you have all three?	5
Ethnicity and sex-specific 99th percentile upper reference limits of high-sensitivity cardiac troponin I among adults in Xinjiang, China	5
Advances in molecular infectious diseases testing in the time of COVID-19	5
Lack of interference of metronidazole with Roche cobas c502 and c702 chemistry tests	5
Serum arachidonic acid levels is a predictor of poor functional outcome in acute intracerebral hemorrhage	5
CYB5R3 homozygous pathogenic variant as a rare cause of cyanosis in the newborn	5
The performance of Carbohydrate Antigen 125-Thomsen-nouveau and anti-Müllerian hormone combined with CA125, Human epididymis protein 4 and Risk of Malignancy Algorithm in diagnosis for patients with E	5
Phenotypic expression of the m.3243A > G variant not only depends on heteroplasmy or haplotype	5
Letter to the Editor: On moving average and internal quality control	5
More about the random uncertainty of photometric determination of hemolysis index on the Abbott Alinity c platform	5
Long-term follow-up with a clinical decision support system based on laboratory reports to manage patients with biochemical recurrence after radical prostatectomy	5
Hyperphosphatemia rather than hypophosphatemia indicates a poor prognosis in patients with sepsis	5
Multiplex assessment of SARS-CoV-2 antibodies improves assay sensitivity and correlation with neutralizing antibodies	5
Serial secretoneurin measurement and risk of ventricular arrhythmias and death in patients with left ventricular systolic dysfunction	5
Innovations in infectious disease testing: Leveraging COVID-19 pandemic technologies for the future	5
Altered plasma levels of apixaban in major gastrointestinal tract surgery: A case report and review of the literature	5
Dose optimization and target attainment of vancomycin in children	5
Continuous reference intervals for 19 endocrine, fertility, and immunochemical markers in the CALIPER cohort of healthy children and adolescents	5
Clinically relevant urine creatinine underestimation in the low concentration range on the Siemens Dimension Vista®	5
Two SARS-CoV-2 serology assays detect antibodies in the sera of individuals diagnosed with SARS-CoV-2 Omicron variant	5
Editorial Board	5

Selected abstracts presented at the annual conference of the Canadian Society of Clinical Chemists (CSCC), 2023	5
MELAS a clinically and genetically heterogeneous syndrome	5
Monitoring intracellular tacrolimus concentrations and its relationship with rejection in the early phase after renal transplantation	5
Investigating angiogenin/ribonuclease 5 as a diagnostic biomarker for bladder cancer: In-depth analysis from a systematic review and meta-analysis	5
Primer Part 1 − Preparing a laboratory quality improvement project	5
Factors influencing creatine kinase-MM concentrations in newborns and implications for newborn screening for Duchenne muscular dystrophy	5
The 10 most frequently requested blood tests in the Capital Region of Denmark, 2010–2019 and simulated effect of minimal retesting intervals	5
Evaluation of BD Barricor™ and PST™ blood collection tubes compared to serum for testing 11 therapeutic drugs on a Roche Cobas® 8000 platform	5
Spirited away: Can ethanol testing in add-on orders provide meaningful results?	5