Clinical Biochemistry

Article	Citations
Reply to Letter to the Editor “The importance of SII and FIB-4 scores in predicting mortality in idiopathic pulmonary fibrosis patients”	92
Relationship between analytical imprecision and coefficient of determination (R2) of the calibration curve	80
The significance of PCSK-9′s level and polymorphism in premature coronary artery disease: Relation to risk and severity	33
Editorial Board	31
Hydroxocobalamin does not interfere with high-sensitivity cardiac troponin T assay	28
Comparison of two (data mining) indirect approaches for between-subject biological variation determination	28
Biomarkers in the prognostic evaluation of ischemic stroke: Is there benefit in the measurements of TREM-1 and TREM-2 in the acute phase?	28
Serum levels of sonic hedgehog in patients with IgA nephropathy are closely associated with intrarenal arteriolar lesions	28
The pitfalls and significance of using ratios and calculated parameters in laboratory medicine	25
Measuring copeptin, a surrogate for vasopressin in patients with hypertension – Can it identify those who are volume Responsive?	25
The biological diagnosis of Alzheimer’s disease using blood-based biomarkers: a Canadian prospective	25
IL-23 and IL-17 in acute ischemic stroke: Correlation with stroke scales and prognostic value	24
Comparison of laboratory results and pain perception in self-sampled capillary blood versus venous blood sampling: a systematic review and meta-analysis	23
A circRNA-based ceRNA network shows its diagnostic value in non-small-cell lung cancer	23
Association of phospholipid transfer protein (PLTP) and the effect of genetic variant rs5072 on hypertriglyceridemia and atherogenic dyslipidemia in children and adolescents from Southeastern Mexico	20
Reducing AST orders by reviewing test panels	20
Editorial Board	19
Association of the C-terminal 42-peptide fragment of alpha-1 antitrypsin with the severity of ARDS: A pilot study	19
Editorial Board	18
Whole-exome sequencing reveals a novel frameshift mutation in a consanguineous family with a hereditary coagulation factor XII deficiency	17
Comparison of 8 methods for univariate statistical exclusion of pathological subpopulations for indirect reference intervals and biological variation studies	17
Accuracy-based proficiency testing for estradiol measurements	16
Defining blood gas analysis stability limits across five sample types	16
Novel threshold value of midnight serum cortisol for diagnosis of hypercortisolism using the Roche Cortisol II assay	15
Limited incremental value of growth differentiation factor 15 in the initial evaluation of low and intermediate risk acute chest pain patients	15

Evaluation of noninvasive prenatal screening for copy number variations among screening laboratories	15
Creatine kinase test diagnostic accuracy in neonatal screening for Duchenne Muscular Dystrophy: A systematic review	15
Corrigendum to “Optimization and validation of the Kairos Amino Acid Kit for plasma amino acid monitoring in inherited metabolic disorder patients” [Clin. Biochem. 138 (2025) 110960]	15
Explainable artificial intelligence for LDL cholesterol prediction and classification	15
Editorial Board	15
Editorial Board	14
A spreadsheet tool for designing statistical quality control programs based on patient risk parameters	14
Treatment target achievement in patients with familial hypercholesterolemia: A real-world descriptive study	14
Editorial Board	14
The presence of white cell Jordan's anomaly in multiple Acyl-CoA dehydrogenase deficiency: A case report and implications for clinical practice	13
Expression profile of microRNAs in patients with decompensated cirrhosis by small RNA deep sequencing	13
Paraoxonase 2 C311S single nucleotide polymorphism is associated with type C lesions in coronary atherosclerosis	13
14–3-3 η ETA protein as a potential marker of joint damage in gout	13
Comparison of fecal calprotectin and pancreatic elastase assays based on proficiency testing results	13
Retraction notice to “Distributions of alcohol use biomarkers including ethanol, phosphatidylethanol, ethyl glucuronide and ethyl sulfate in clinical and forensic testing” [Clin. Biochem. 82 (2020) 85	13
Editorial Board	12
Evaluation of an adenosine deaminase (ADA) assay in serum, pleural, pericardial, peritoneal, and cerebrospinal fluids on the Roche cobas c501 analyzer	12
Assessment of accuracy, clinical validity, and analytical linearity in point-of-care glucose monitoring devices for diabetes mellitus: A systematic review and meta-analysis	12
Artificial intelligence: A step forward in the clinical laboratory, a decision maker hub	12
The impact of environmental factors on external and internal specimen transport	12
Biological variation of secretoneurin; a novel cardiovascular biomarker implicated in arrhythmogenesis	11
YKL-40 levels in cerebrospinal fluid serve as a diagnostic biomarker for post-neurosurgical bacterial meningitis in patients with stroke	11
The case of a bloody mess – Bictegravir/emtricitabine/tenofovir alafenamide induced colitis	11
Validation and application of volumetric absorptive microsampling (VAMS) dried blood method for phenylalanine measurement in patients with phenylketonuria	11
Dried blood spot reference intervals for 18 amino acids in a 1 to 6 years old pediatric cohort	11
Long term false positive hsTnI on Alinity I probably caused by macrotroponin complex: Case report	11
Screening and confirmation methods for the qualitative identification of nine phytocannabinoids in urine by LC-MS/MS	11
Serum biotin interference: A troublemaker in hormone immunoassays	11
Plasma trimethylamine levels predict adverse cardiovascular events in sudden cardiac arrest Survivors: A prospective cohort study	11
Evaluation of fecal SYPL1 as a diagnostic biomarker in colorectal cancer	11
Combination of antibody tests against SARS-CoV-2 for health care workers after vaccination	11
Clinical significance of fecal Syndecan-2 gene methylation combined with blood tumor abnormal protein detection in the diagnosis of colorectal cancer and precancerous lesions	11
Biological testing during acute psychological stress: A hindrance or an opportunity?	11
Green laboratory practice: Top 2 environmental recommendations for clinical laboratories	10
Methods for determining clinical utility	10
2024 CSCC / SQBC Joint AnnualConference	10
Serum netrin-1 levels are high in Rheumatoid arthritis associated interstitial lung disease	10
Editorial Board	10
Large viral meningoencephalitis CSF serologic panel lacks utility in clinical decisions and outcomes	10
Analytical performance comparing siemens whole blood point of care Atellica VTLi to the central laboratory plasma Atellica IM high-sensitivity cardiac troponin I assays	10
Analytical Performance Evaluation for Estradiol using Liquid Chromatography–Tandem Mass Spectrometry	10
Rethinking research funding through a sustainability Lens	10
Demonstration of equivocal anti-glomerular basement membrane antibody positivity as a non-specific reaction through multiple immunologic assays in a case of pediatric asymptomatic hematuria	9
Using differential mobility spectrometry to improve the specificity of targeted measurements of 2,3-dinor 11β-Prostaglandin F2α	9
Vascular endothelial growth factor A, a potential non-invasive biomarker for metabolic dysfunction-associated steatotic liver disease progression	9
Estimation formulas for ionized magnesium in critically ill children	9
Amikacin therapeutic drug monitoring: Evaluation of therapy performance and analytical techniques in a developing country setting	9
Editorial Board	9
Current status of therapeutic drug monitoring for methotrexate, imatinib, paclitaxel in China	9
Reducing unnecessary free thyroid hormone testing by the reinforcement of a reflexive algorithm in an outpatient environment	9

Elevated urine norepinephrine levels and alcohol use: A relationship that should be not neglected	9
Prognostic value of secretoneurin in chronic heart failure. Data from the GISSI-Heart Failure trial	9
Editorial Board	9
Validating the NIH LDL-C equation in a specialized lipid cohort: Does it add up?	9
Huge discrepancy between serum immunoglobulin concentration and proteinemia due to heavy chain disease	9
Secretoneurin is not associated with cardiovascular events or mortality in patients treated with hemodialysis: A prospective multicenter cohort study	8
Repression of miR-146a in predicting poor treatment outcome in triple-negative breast cancer	8
Pediatric ionized calcium reference intervals from archived radiometer data	8
Clinical concordance assessment should be an integral component of laboratory method comparison studies: A regression transference of routine clinical data approach	8
A rebuttal to: A letter to editor entitled: “A panel (CA19-9, CEA and PIVKA-II) of serum markers for pancreatic cancer diagnosis”	8
Carrier frequency and molecular basis of hemoglobinopathies among blood donors in eastern Morocco: Implications for blood donation and genetic diagnosis	8
Towards achieving the end of the HIV epidemic: Advances, challenges and scaling-up strategies	8
Laboratory reflex testing strategy for the early identification of primary care patients with multiple myeloma	8
Autoverification-based algorithms to detect preanalytical errors: Two examples	8
Detection of 58 fentanyl analogs using ARK fentanyl II and Immunalysis fentanyl immunoassays	8
Impact of lot-to-lot variation in absolute neutrophil count measured by a point-of-care device in patients receiving clozapine treatment	8
Editorial Board	8
Biomarker profiling for infection diagnosis in emergency departments: A diagnostic study evaluating C-reactive protein, procalcitonin, Club Cell Protein 16, interleukin-6, chitinase-like protein, and	8
Characterizing M-protein light chain glycosylation via mass spectrometry	7
HER2 gene mutations and matrix biomarkers in breast cancer	7
Canadian guidance for diagnosis and management of acute hepatic porphyrias	7
Serum human epididymis protein 4 is associated with disease severity in patients with IgA nephropathy	7
Inflammatory markers and their association with preeclampsia among pregnant women: A systematic review and meta-analysis	7
Krebs von den Lungen-6 (KL-6) as a diagnostic marker for pulmonary fibrosis: A systematic review and meta-analysis	7
Phenotyping and genotyping for the dihydropyrimidine dehydrogenase test in Italy: a precise diagnostic strategy to detect rare variants and improve drug administration	7
Expression profile of long-noncoding RNAs MIR31HG, NKILA, and PACER in systemic lupus erythematosus patients	7
Elevated level of platelet factor 4 in follicular fluid is associated with polycystic ovary syndrome	7
The importance of SII and FIB-4 scores in predicting mortality in idiopathic pulmonary fibrosis patients	7
Serum extracellular vesicles with NSD1 and FBXO7 mRNA as novel biomarkers for gastric cancer	7
In vivo and in vitro relationship between ionized magnesium and ionized calcium	7
Construction of a multi-classified decision tree model for identifying malignant pleural effusion and tuberculous pleural effusion	7
Serum levels of 4-hydroxynonenal adducts and responding autoantibodies correlate with the pathogenesis from hyperglycemia to Alzheimer’s disease	7
Freelite and Kloneus assays in free light chain measurements in patients with renal impairment	7
Editorial Board	7
Less is more: minimum sample volume for the free phenytoin assay on the Roche Cobas c503 analyzer	7
Biotinidase activity is affected by both seasonal temperature and filter collection cards	7
Are discordant cTnI results detected in an analytical comparison clinically irrelevant?	7
Bias in IGF-1 concentrations and interpretation across three different clinical laboratory assays	7
Methods of the ivota triAl of he Atellica VTLi point of care emergenc de artment high sensitivity troponin eval ation	6
Innovations in infectious disease testing: Leveraging COVID-19 pandemic technologies for the future	6
Lack of interference of metronidazole with Roche cobas c502 and c702 chemistry tests	6
MELAS a clinically and genetically heterogeneous syndrome	6
Corrigendum to “The biological diagnosis of Alzheimer’s disease using blood-based biomarkers: A Canadian prospective” [Clin. Biochem. 139 (2025); pages 1–17 /110980]	6
Plasma levels of bone morphogenic protein-4 are downregulated in elderly hypertensive patients with heart failure with preserved ejection fraction	6
Evaluation of an automated assay for eosinophil-derived neurotoxin in serum	6
Novel mutations associated with carnitine-acylcarnitine translocase and carnitine palmitoyl transferase 2 deficiencies in Malaysia	6
Accuracy of determination of free light chains (Kappa and Lambda) in plasma and serum by Swedish laboratories as monitored by external quality assessment	6
Qualitative and quantitative detection of SARS-CoV-2 antibodies from dried blood spots	6
The 10 most frequently requested blood tests in the Capital Region of Denmark, 2010–2019 and simulated effect of minimal retesting intervals	6
Minimal mathematical model for glycation of albumin	6
Serial secretoneurin measurement and risk of ventricular arrhythmias and death in patients with left ventricular systolic dysfunction	6
Evaluation of Siemens Atellica AMH assay and comparison with Roche, Beckman and Ansh Labs	6
Public knowledge of SARS-CoV-2 serological and viral lineage laboratory testing and result interpretation: A GENCOV study cross-sectional survey	6
Editorial Board	6
The potential of anti-glutamic acid decarboxylase antibodies to support a diagnosis of autoimmune diabetes mellitus	6
Diagnostic performance of a rapid, novel, whole blood, point of care high-sensitivity cardiac troponin I assay for myocardial infarction	6
Dose optimization and target attainment of vancomycin in children	6
Advances in molecular infectious diseases testing in the time of COVID-19	6
Establishing sustainable quality improvement in the clinical laboratory: Redesign of the total testing process and digital transformation of routine quality assurance activities	6
Agreement of LC-MS assays for IGF-1 traceable to NIST and WHO standards permits harmonization of reference intervals between laboratories	6
Innovations in infectious disease diagnostics	6
A new assay falsely increases lactate dehydrogenase in plasma but not in serum	6
CYB5R3 homozygous pathogenic variant as a rare cause of cyanosis in the newborn	5
Ethnicity and sex-specific 99th percentile upper reference limits of high-sensitivity cardiac troponin I among adults in Xinjiang, China	5
Editorial Board	5
The performance of Carbohydrate Antigen 125-Thomsen-nouveau and anti-Müllerian hormone combined with CA125, Human epididymis protein 4 and Risk of Malignancy Algorithm in diagnosis for patients with E	5
Urine proteome uncovers common mechanisms between mucopolysaccharidosis types I and II	5
Functional characterization of the p.(Gln195His) or Tainan and novel p.(Ser184Cys) or Toluca glucose-6-phosphate dehydrogenase (G6PD) gene natural variants identified through Mexican newborn screening	5
More about the random uncertainty of photometric determination of hemolysis index on the Abbott Alinity c platform	5
Phenotypic expression of the m.3243A > G variant not only depends on heteroplasmy or haplotype	5
Therapeutic drug monitoring of levetiracetam – Is dried blood spot sampling suitable?	5
Monitoring intracellular tacrolimus concentrations and its relationship with rejection in the early phase after renal transplantation	5
Altered plasma levels of apixaban in major gastrointestinal tract surgery: A case report and review of the literature	5
Medical appropriateness and economics of nucleic acid amplification testing for infectious diseases	5
Primer Part 1 − Preparing a laboratory quality improvement project	5
Spirited away: Can ethanol testing in add-on orders provide meaningful results?	5
Evaluation of BD Barricor™ and PST™ blood collection tubes compared to serum for testing 11 therapeutic drugs on a Roche Cobas® 8000 platform	5
Letter to the Editor: On moving average and internal quality control	5
Two SARS-CoV-2 serology assays detect antibodies in the sera of individuals diagnosed with SARS-CoV-2 Omicron variant	5
An improved and economical LLE-LC/MS method for quantifying phosphatidylethanol: Identification and separation of isotopic cross-talk in clinical alcohol testing	5

The biological diagnosis of Alzheimer’s disease using blood-based biomarkers: A Canadian prospective	5
Implementing minimal request intervals for laboratory tests: a utilization management study across eight hospitals in South Iran	5
Investigating angiogenin/ribonuclease 5 as a diagnostic biomarker for bladder cancer: In-depth analysis from a systematic review and meta-analysis	5
Factors influencing creatine kinase-MM concentrations in newborns and implications for newborn screening for Duchenne muscular dystrophy	5
Selected abstracts presented at the annual conference of the Canadian Society of Clinical Chemists (CSCC), 2023	5
A novel and robust analytical method for the quantification of perospirone in human plasma using an LC–MS/MS system with self-internal standard calibration	5
Increased serum SGLT2 and its potential diagnostic and prognostic value in patients with acute ischemic stroke	5
Long-term follow-up with a clinical decision support system based on laboratory reports to manage patients with biochemical recurrence after radical prostatectomy	5
Clinically relevant urine creatinine underestimation in the low concentration range on the Siemens Dimension Vista®	5
Enhanced detection and Characterization of M-proteins in multiple myeloma patients using An Agilent AssayMAP Bravo liquid handling system coupled to an LC-QTOF	5
Serum arachidonic acid levels is a predictor of poor functional outcome in acute intracerebral hemorrhage	5