Clinical Biochemistry

Article	Citations
After another decade: LC–MS/MS became routine in clinical diagnostics	163
Laboratory abnormalities in children with mild and severe coronavirus disease 2019 (COVID-19): A pooled analysis and review	106
CRISPR-based tools: Alternative methods for the diagnosis of COVID-19	66
Roles of matrix metalloproteinase-7 (MMP-7) in cancer	62
Are antioxidant enzymes essential markers in the diagnosis and monitoring of cancer patients – A review	60
Current immunoassay methods and their applications to clinically used biomarkers of breast cancer	47
Shrunken pore syndrome - a common kidney disorder with high mortality. Diagnosis, prevalence, pathophysiology and treatment options	43
The application of fully automated dried blood spot analysis for liquid chromatography-tandem mass spectrometry using the CAMAG DBS-MS 500 autosampler	37
Diagnostic value of serum glypican-3 alone and in combination with AFP as an aid in the diagnosis of liver cancer	36
Gender-specific reference values for high-sensitivity cardiac troponin T and I in well-phenotyped healthy individuals and validity of high-sensitivity assay designation	35
Real-world big-data studies in laboratory medicine: Current status, application, and future considerations	31
OMICS insights into cancer histology; Metabolomics and proteomics approach	28
Applications of machine learning in routine laboratory medicine: Current state and future directions	26
Genetic signature of CTLA-4, BTLA, TIM-3 and LAG-3 molecular expression in colorectal cancer patients: Implications in diagnosis and survival outcomes	26
Current use of bone turnover markers in the management of osteoporosis	25
Advancements in the gold standard: Measuring steroid sex hormones by mass spectrometry	25
Discovery and comparison of serum biomarkers for diabetes mellitus and metabolic syndrome based on UPLC-Q-TOF/MS	23
Uncarboxylated matrix Gla-protein: A biomarker of vitamin K status and cardiovascular risk	23
A novel, mitochondrial, internal tRNA-derived RNA fragment possesses clinical utility as a molecular prognostic biomarker in chronic lymphocytic leukemia	22
High clinical performance and quantitative assessment of antibody kinetics using a dual recognition assay for the detection of SARS-CoV-2 IgM and IgG antibodies	21
Effects of fetuin-A with diverse functions and multiple mechanisms on human health	20
Emerging key laboratory tests for patients with COVID-19	19
Validation of an approach using only patient big data from clinical laboratories to establish reference intervals for thyroid hormones based on data mining	19
Early prediction of COVID-19-associated acute kidney injury: Are serum NGAL and serum Cystatin C levels better than serum creatinine?	18
Validating the NIH LDL-C equation in a specialized lipid cohort: Does it add up?	18

2019 Novel coronavirus disease (COVID-19) in hemodialysis patients: A report of two cases	17
The role of Monocyte Distribution Width (MDW) in the prognosis and monitoring of COVID-19 patients	17
Initial determination of COVID-19 seroprevalence among outpatients and healthcare workers in Minnesota using a novel SARS-CoV-2 total antibody ELISA	17
Single test rule-out of acute myocardial infarction using the limit of detection of a new high-sensitivity troponin I assay	17
Staff rostering, split team arrangement, social distancing (physical distancing) and use of personal protective equipment to minimize risk of workplace transmission during the COVID-19 pandemic: A sim	16
Simultaneous quantification of plasma levels of 12 antimicrobial agents including carbapenem, anti-methicillin-resistant Staphylococcus aureus agent, quinolone and azole used in intensive care unit us	16
An isotope dilution LC-MS/MS based candidate reference method for the quantification of cyclosporine A, tacrolimus, sirolimus and everolimus in human whole blood	16
The use of aptamers in prostate cancer: A systematic review of theranostic applications	16
Differences in biomarker concentrations and predictions of long-term outcome in patients with ST-elevation and non-ST-elevation myocardial infarction	15
Using high sensitivity cardiac troponin values in patients with SARS-CoV-2 infection (COVID-19): The Padova experience	15
Room-temperature-storable PCR mixes for SARS-CoV-2 detection	15
Superiority of high sensitivity cardiac troponin T vs. I for long-term prognostic value in patients with chest pain; data from the Akershus cardiac Examination (ACE) 3 study	15
Analytical and clinical validation of dried blood spot and volumetric absorptive microsampling for measurement of tacrolimus and creatinine after renal transplantation	14
Comparison of serologic and molecular SARS-CoV 2 results in a large cohort in Southern Tuscany demonstrates a role for serologic testing to increase diagnostic sensitivity	14
Clinical evaluation of Ortho Clinical Diagnostics high-sensitivity cardiac Troponin I assay in patients with symptoms suggestive of acute coronary syndrome	14
Antioxidants other than vitamin C may be detected by glucose meters: Immediate relevance for patients with disorders targeted by antioxidant therapies	14
Quality assurance practices for point of care testing programs: Recommendations by the Canadian society of clinical chemists point of care testing interest group	14
Canadian society of clinical chemists (CSCC) interim consensus guidance for testing and reporting of SARS-CoV-2 serology	14
Serum exosomal hsa_circ_0069313 has a potential to diagnose more aggressive non-small cell lung cancer	14
Increased oxidative stress and inflammatory markers contrasting with the activation of the cholinergic anti-inflammatory pathway in patients with metabolic syndrome	14
Hyperphosphatemia rather than hypophosphatemia indicates a poor prognosis in patients with sepsis	13
Measuring the contribution of Lp(a) cholesterol towards LDL-C interpretation	13
The potential of liquid biopsies in gastrointestinal cancer	13
Evaluation of complement system proteins C3a, C5a and C6 in patients of endometriosis	13
Analytical and biological assessment of circulating human erythroferrone	13
Gender differences in LDL and HDL subfractions in atherogenic and nonatherogenic phenotypes	12
Performance of conventional histopathology and GeneXpert MTB/RIF in the diagnosis of spinal tuberculosis from bone specimens: A prospective clinical study	12
Highly sensitive LC-MS/MS analysis of catecholamines in plasma	12
Measuring magnesium – Physiological, clinical and analytical perspectives	12
Pivotal findings for a high-sensitivity cardiac troponin assay: Results of the HIGH-US study	12
Urine toxicology screening by liquid chromatography time-of-flight mass spectrometry in a quaternary hospital setting	12
Considerations for understanding protein measurements: Identification of formation, degradation and more pathological relevant epitopes	12
Chemotherapy-associated clonal hematopoiesis mutations should be taken seriously in plasma cell-free DNA KRAS/NRAS/BRAF genotyping for metastatic colorectal cancer	12
Change in troponin concentrations in patients with macrotroponin: An in vitro mixing study	12
Placenta-specific plasma miR518b is a potential biomarker for preeclampsia	12
Establishing reference intervals for major biochemical analytes for the Russian population: a research conducted as a part of the IFCC global study on reference values	11
A focus on the roles of histones in health and diseases	11
Simultaneous quantification of rituximab and eculizumab in human plasma by liquid chromatography-tandem mass spectrometry and comparison with rituximab ELISA kits	11
Diagnostic performance of a rapid, novel, whole blood, point of care high-sensitivity cardiac troponin I assay for myocardial infarction	11
Novel microRNA biomarkers of systemic lupus erythematosus in plasma: miR-124-3p and miR-377-3p	11
Interest of blood biomarkers to predict lesions in medical imaging in the context of mild traumatic brain injury	11
HDL-associated apoCIII plays an independent role in predicting postprandial hypertriglyceridemia	11
Internal quality control: Moving average algorithms outperform Westgard rules	11
Aspirin: Bitter pill or miracle drug?	11
A point-of-need platform for rapid measurement of a host-protein score that differentiates bacterial from viral infection: Analytical evaluation	11
A 3-min UPLC-MS/MS method for the simultaneous determination of plasma catecholamines and their metabolites: Method verification and diagnostic efficiency	11
TSH continuous reference intervals by indirect methods: A Comparisons to Partitioned Reference Intervals	11
Anti-SARS-CoV-2 IgM improves clinical sensitivity early in disease course	11
Serum expression and diagnostic potential of long non-coding RNAs NEAT1 and TUG1 in viral hepatitis C and viral hepatitis C-associated hepatocellular carcinoma	11
Integrating quality control and external quality assurance	11

Creatine kinase test diagnostic accuracy in neonatal screening for Duchenne Muscular Dystrophy: A systematic review	10
Single-nucleotide polymorphisms (SNPs) of antioxidant enzymes SOD2 and GSTP1 genes and SLE risk and severity in an Egyptian pediatric population	10
Donor-specific ELISPOT assay for predicting acute rejection and allograft function after kidney transplantation: A systematic review and meta-analysis	10
Detection of glucosylsphingosine in dried blood spots for diagnosis of Gaucher disease by LC-MS/MS	10
Sfrp5/Wnt5a and leptin/adiponectin levels in the serum and the periarterial adipose tissue of patients with peripheral arterial occlusive disease	10
Intense sport practices and cardiac biomarkers	10
Method validation for a multi-element panel in serum by inductively coupled plasma mass spectrometry (ICP-MS)	10
Association of vitamin D receptor genetic variants with bone mineral density and inflammatory markers in rheumatoid arthritis	10
The potential value of the neutrophil to lymphocyte ratio for early differential diagnosis and prognosis assessment in patients with aortic dissection	10
A comparison of SARS-CoV-2 nucleocapsid and spike antibody detection using three commercially available automated immunoassays	10
Distributions of alcohol use biomarkers including ethanol, phosphatidylethanol, ethyl glucuronide and ethyl sulfate in clinical and forensic testing	10
New prognostic markers in pulmonary arterial hypertension: CRP to albumin ratio and uric acid	10
Laboratory biomarkers of Multiple Sclerosis (MS)	10
Age-wise trends in alkaline phosphatase activity in 167,625 Chinese children aged 0–18 years	10
Clearing drug interferences in myeloma treatment using mass spectrometry	9
Screening and confirmation methods for the qualitative identification of nine phytocannabinoids in urine by LC-MS/MS	9
Monitoring intracellular tacrolimus concentrations and its relationship with rejection in the early phase after renal transplantation	9
Data mining: Biological and temporal factors associated with blood parathyroid hormone, vitamin D, and calcium concentrations in the Southwestern Chinese population	9
Orexin-A measurement in narcolepsy: A stability study and a comparison of LC-MS/MS and immunoassays	9
Storage conditions, sample integrity, interferences, and a decision tool for investigating unusual high-sensitivity cardiac troponin results	9
Validation of COVID-19 serologic tests and large scale screening of asymptomatic healthcare workers	9
Lipid profile and lipid oxidative modification parameters in the first trimester of high- risk pregnancies - possibilities for preeclampsia prediction	9
Reducing free thyroid hormone testing through multiple Plan-Do-Study-Act cycles	9
Prevalence of detectable biotin in The Netherlands in relation to risk on immunoassay interference	9
Effect of sample size and the traditional parametric, nonparametric, and robust methods on the establishment of reference intervals: Evidence from real world data	9
Defining appropriate utilization of AST testing	9
Comparison of 8 methods for univariate statistical exclusion of pathological subpopulations for indirect reference intervals and biological variation studies	9
Serum free light chain reference intervals in an Optilite and their influence on clinical guidelines	9
Thyroid panel reference intervals in healthy children and adolescents: A Spanish cohort	9
Erythrocyte reduced/oxidized glutathione and serum thiol/disulfide homeostasis in patients with rheumatoid arthritis	8
Interim analysis of the clinical performance of five SARS-Cov-2 serology assays	8
Evaluation of the new Beckman Coulter Access hsTnI: 99th percentile upper reference limits according to age and sex in the Korean population	8
Plasma RNA sequencing of extracellular RNAs reveals potential biomarkers for non-small cell lung cancer	8
Innovations in infectious disease testing: Leveraging COVID-19 pandemic technologies for the future	8
Clinical laboratory characteristics of patients with obstructive jaundice accompanied by dyslipidemia	8
An in vitro comparison of four different immunoassays for the monitoring of Infliximab biosimilars drug levels	8
Multiplex assessment of SARS-CoV-2 antibodies improves assay sensitivity and correlation with neutralizing antibodies	8
Evaluation of SARS-CoV-2 prototype serologic test in hospitalized patients	8
Comparison of capillary and venous blood sampling for routine coagulation assays	8
Differential associations of cardiac troponin T and cardiac troponin I with coronary artery pathology and dynamics in response to short-duration exercise	8
Relationship between biological variation and delta check rules performance	8
Evaluation of plasma ACTH stability using the Roche Elecsys immunoassay	8
Cardiac troponin I measured with a very high sensitivity assay predicts subclinical carotid atherosclerosis: The Akershus Cardiac Examination 1950 Study	8
Continuous reference intervals for 21 biochemical and hematological analytes in healthy Chinese children and adolescents: The PRINCE study	8
Alu cell-free DNA concentration, Alu index, and LINE-1 hypomethylation as a cancer predictor	8
Validation and comparison of five data mining algorithms using big data from clinical laboratories to establish reference intervals of thyroid hormones for older adults	7
Evaluation of Abbott ID NOW COVID-19 POC test performance characteristics and integration in the regional health network workflows to improve health care delivery	7
Ski: Double roles in cancers	7
How to write (and how not to write) a scientific review article	7
SIRT2 and SIRT3 expression correlates with redox imbalance and advanced clinical stage in patients with multiple myeloma	7
Association between circulating asprosin levels and carotid atherosclerotic plaque in patients with type 2 diabetes	7
Six novel variants in the PKLR gene associated with pyruvate kinase deficiency in Argentinian patients	7
Hydroxocobalamin interference in routine laboratory tests: Development of a protocol for identifying samples and reporting results from patients treated with CyanokitTM	7
The potential value of Copeptin and Pentraxin3 for evaluating the severity of coronary stenosis in patients with coronary artery disease	7
Statistical methods used in the estimation of age-specific paediatric reference intervals for laboratory blood tests: A systematic review	7
Serum levels of 4-hydroxynonenal adducts and responding autoantibodies correlate with the pathogenesis from hyperglycemia to Alzheimer’s disease	7
Serial cardiac biomarkers for risk stratification of patients with COVID-19	6
Analytical and clinical performance of cPass neutralizing antibodies assay	6
Comparing the diagnostic value of serum oligosaccharide chain (G-test) and alpha-fetoprotein for hepatitis B virus-related liver cancer	6
Pathophysiology and significance of natriuretic peptides in patients with end-stage kidney disease	6
Serum oncostatin M is a potential biomarker of disease activity and infliximab response in inflammatory bowel disease measured by chemiluminescence immunoassay	6
Cardiac troponin T versus cardiac troponin I for mortality risk prediction: Is one biomarker better than the other?	6
Reverse pseudohyperkalemia and pseudohyponatremia in a patient with B-cell non-Hodgkin lymphoma	6
Label-free peptide quantification coupled with in silico mapping of proteases for identification of potential serum biomarkers in gastric adenocarcinoma patients	6
Serum amyloid A1 can be a novel biomarker for evaluating the presence and severity of acute coronary syndrome	6
High-sensitivity cardiac troponin T and N-terminal pro-B-type natriuretic peptide in acute heart failure: Data from the ACE 2 study	6
Uncommon antinuclear antibody patterns as diagnostic indicators	6
Interleukin-18 promoter −137 G/C polymorphism (rs187238) is associated with biochemical markers of renal function and cardiovascular disease in type 2 diabetes patients	6
The clinical role of combined serum C1q and hsCRP in predicting coronary artery disease	6
Lysosomal storage disorders: Novel and frequent pathogenic variants in a large cohort of Indian patients of Pompe, Fabry, Gaucher and Hurler disease	6
Qualitative and quantitative detection of SARS-CoV-2 antibodies from dried blood spots	6
NUDT15: A bench to bedside success story	6
A model to establish autoverification in the clinical laboratory	6
Glucose-6-phosphate dehydrogenase deficiency and SARS-CoV-2 mortality: Is there a link and what should we do?	6
A novel 15.8 kb deletion α-thalassemia confirmed by long-read single-molecule real-time sequencing: Hematological phenotypes and molecular characterization	6
Evaluation of the Visby medical COVID-19 point of care nucleic acid amplification test	6
Polymorphisms of interleukin 4 and interleukin 4 receptor genes and bronchial asthma risk among Egyptian children	6
Precision of autoantibody assays in clinical diagnostic laboratories: What is the reality?	6
Elevated plasma levels of asymmetric dimethylarginine and the risk for arrhythmic death in ischemic and non-ischemic, dilated cardiomyopathy – A prospective, controlled long-term study	6
Biotinidase activity is affected by both seasonal temperature and filter collection cards	6

The importance of neopterin in COVID-19: The prognostic value and relation with the disease severity	6
Soluble urokinase plasminogen activator receptor (suPAR) is lower in disease-free patients but cannot rule out incident disease in patients with suspected cancer	5
Comparison of the Friedewald equation with Martin and Sampson equations for estimating LDL cholesterol in hypertriglyceridemic adults	5
Using the hemolysis index of Abbott’s Alinity c for the measurement of plasma free hemoglobin in ECMO patients	5
Branched chain amino acids are associated with metabolic complications in liver transplant recipients	5
Staged reflexive artificial intelligence driven testing algorithms for early diagnosis of pituitary disorders	5
Preparation, stability and commutability of candidate reference materials for lactate dehydrogenase (LDH)	5
Application of a six sigma model to the evaluation of the analytical performance of serum enzyme assays and the design of a quality control strategy for these assays: A multicentre study	5
No increase in the incidence of cardiac troponin I concentration above the 99th percentile by Siemens Centaur high-sensitivity compared to the contemporary assay	5
External validation of the clinical chemistry score	5
The use of freeze-dried blood samples affects the results of a dried blood spot analysis	5
Determination of clinically acceptable cut-offs for hemolysis index: An application of bootstrap method using real-world data	5
Long non-coding RNA LINC01793 as a potential diagnostic biomarker of hepatitis B virus-related hepatocellular carcinoma	5
Continuous reference intervals for 19 endocrine, fertility, and immunochemical markers in the CALIPER cohort of healthy children and adolescents	5
A novel COQ8A missense variant associated with a mild form of primary coenzyme Q10 deficiency type 4	5
Multi-platform analytical evaluation of the Beckman Coulter Access high-sensitivity troponin I assay across different laboratory sites using Barricor plasma	5
Using quantitative immunoprecipitation mass spectrometry (QIP-MS) to identify low level monoclonal proteins	5
Defining blood gas analysis stability limits across five sample types	5
Rapid inductively coupled plasma mass spectrometry method to determine iodine in amniotic fluid, breast milk and cerebrospinal fluid	5
Biomarkers in the prognostic evaluation of ischemic stroke: Is there benefit in the measurements of TREM-1 and TREM-2 in the acute phase?	5
Analytical and clinical characterization of a novel high-sensitivity cardiac troponin assay in a United States population	5
Identification of a novel 10.3 kb deletion causing α0-thalassemia by third-generation sequencing: Pedigree analysis and genetic diagnosis	5
Reducing the probability of falsely elevated HbA1c results in diabetic patients by applying automated and educative HbA1c re-testing intervals	5
Alpha-1-antitrypsin molecular testing in Canada: A seven year, multi-centre comparison	5
Proteomic applications in pathology and laboratory medicine: Present state and future prospects	5
High-throughput simultaneous quantification of five azole anti-fungal agents and one active metabolite in human plasma using ultra-high-performance liquid chromatography coupled to tandem mass spectro	5
Analytical characterization of the SARS-CoV-2 EURM-017 reference material	5
Serologically assessed heat shock protein 47 is related to fibrosis stage in early compensated alcohol-related liver disease	5
Updated ferritin reference intervals for the Roche Elecsys® immunoassay	5
IL-23 and IL-17 in acute ischemic stroke: Correlation with stroke scales and prognostic value	5
Novel mutations associated with carnitine-acylcarnitine translocase and carnitine palmitoyl transferase 2 deficiencies in Malaysia	5
Salivary antibodies are detected with a commercial anti-SARS-CoV-2 assay only after two doses of vaccine using serum thresholds	5