Clinical Biochemistry

Article	Citations
Reply to Letter to the Editor “The importance of SII and FIB-4 scores in predicting mortality in idiopathic pulmonary fibrosis patients”	106
Editorial Board	93
Comparison of two (data mining) indirect approaches for between-subject biological variation determination	41
The pitfalls and significance of using ratios and calculated parameters in laboratory medicine	37
A circRNA-based ceRNA network shows its diagnostic value in non-small-cell lung cancer	35
The significance of PCSK-9′s level and polymorphism in premature coronary artery disease: Relation to risk and severity	28
The biological diagnosis of Alzheimer’s disease using blood-based biomarkers: a Canadian prospective	28
Interference and failure: The challenge of high-concentration IgM monoclonal protein in capillary zone electrophoresis	27
Serum levels of sonic hedgehog in patients with IgA nephropathy are closely associated with intrarenal arteriolar lesions	26
Measuring copeptin, a surrogate for vasopressin in patients with hypertension – Can it identify those who are volume Responsive?	24
Relationship between analytical imprecision and coefficient of determination (R2) of the calibration curve	21
Comparison of laboratory results and pain perception in self-sampled capillary blood versus venous blood sampling: a systematic review and meta-analysis	21
Reducing AST orders by reviewing test panels	20
Association of phospholipid transfer protein (PLTP) and the effect of genetic variant rs5072 on hypertriglyceridemia and atherogenic dyslipidemia in children and adolescents from Southeastern Mexico	20
Defining blood gas analysis stability limits across five sample types	19
Editorial Board	19
Whole-exome sequencing reveals a novel frameshift mutation in a consanguineous family with a hereditary coagulation factor XII deficiency	19
Editorial Board	19
Limited incremental value of growth differentiation factor 15 in the initial evaluation of low and intermediate risk acute chest pain patients	18
Accuracy-based proficiency testing for estradiol measurements	18
Comparison of 8 methods for univariate statistical exclusion of pathological subpopulations for indirect reference intervals and biological variation studies	17
Corrigendum to “Optimization and validation of the Kairos Amino Acid Kit for plasma amino acid monitoring in inherited metabolic disorder patients” [Clin. Biochem. 138 (2025) 110960]	17
Association of the C-terminal 42-peptide fragment of alpha-1 antitrypsin with the severity of ARDS: A pilot study	17
Editorial Board	16
A spreadsheet tool for designing statistical quality control programs based on patient risk parameters	16

Explainable artificial intelligence for LDL cholesterol prediction and classification	16
Editorial Board	16
Evidence-based extension of reagent shelf-life beyond expiry using patient-based moving averages, westgard sigma rules, and CLSI EP25	16
Comparison of fecal calprotectin and pancreatic elastase assays based on proficiency testing results	15
Paraoxonase 2 C311S single nucleotide polymorphism is associated with type C lesions in coronary atherosclerosis	15
The presence of white cell Jordan's anomaly in multiple Acyl-CoA dehydrogenase deficiency: A case report and implications for clinical practice	15
14–3-3 η ETA protein as a potential marker of joint damage in gout	14
Artificial intelligence: A step forward in the clinical laboratory, a decision maker hub	14
Treatment target achievement in patients with familial hypercholesterolemia: A real-world descriptive study	13
Retraction notice to “Distributions of alcohol use biomarkers including ethanol, phosphatidylethanol, ethyl glucuronide and ethyl sulfate in clinical and forensic testing” [Clin. Biochem. 82 (2020) 85	13
Expression profile of microRNAs in patients with decompensated cirrhosis by small RNA deep sequencing	13
Evaluation of an adenosine deaminase (ADA) assay in serum, pleural, pericardial, peritoneal, and cerebrospinal fluids on the Roche cobas c501 analyzer	13
Fibroblast growth factor 23-induced hypophosphatemia in a malignant phosphaturic mesenchymal tumor: presentation of a rare case	12
Assessment of accuracy, clinical validity, and analytical linearity in point-of-care glucose monitoring devices for diabetes mellitus: A systematic review and meta-analysis	12
Plasma trimethylamine levels predict adverse cardiovascular events in sudden cardiac arrest Survivors: A prospective cohort study	12
Evaluation of noninvasive prenatal screening for copy number variations among screening laboratories	12
Analytical performance comparing siemens whole blood point of care Atellica VTLi to the central laboratory plasma Atellica IM high-sensitivity cardiac troponin I assays	12
The impact of environmental factors on external and internal specimen transport	12
YKL-40 levels in cerebrospinal fluid serve as a diagnostic biomarker for post-neurosurgical bacterial meningitis in patients with stroke	12
Editorial Board	12
Long term false positive hsTnI on Alinity I probably caused by macrotroponin complex: Case report	11
A large-scale survey on the knowledge, attitude, and practice of patient-based real-time quality control in China	11
Evaluation of fecal SYPL1 as a diagnostic biomarker in colorectal cancer	11
Clinical significance of fecal Syndecan-2 gene methylation combined with blood tumor abnormal protein detection in the diagnosis of colorectal cancer and precancerous lesions	11
Impact of the implementation of the Sampson-NIH equation for the calculation of LDL-C in a large community cohort of adult and pediatric patients in Ontario	11
Serum netrin-1 levels are high in Rheumatoid arthritis associated interstitial lung disease	11
Improving the environmental impact paradox of clinical medical laboratories	11
Validation and application of volumetric absorptive microsampling (VAMS) dried blood method for phenylalanine measurement in patients with phenylketonuria	11
A novel fluorescent-labeled serum protein electrophoresis method for detection of monoclonal free light chains in serum	11
Green laboratory practice: Top 2 environmental recommendations for clinical laboratories	10
Large viral meningoencephalitis CSF serologic panel lacks utility in clinical decisions and outcomes	10
Editorial Board	10
Biological testing during acute psychological stress: A hindrance or an opportunity?	10
Analytical Performance Evaluation for Estradiol using Liquid Chromatography–Tandem Mass Spectrometry	10
2024 CSCC / SQBC Joint AnnualConference	10
The case of a bloody mess – Bictegravir/emtricitabine/tenofovir alafenamide induced colitis	10
Dried blood spot reference intervals for 18 amino acids in a 1 to 6 years old pediatric cohort	10
Editorial Board	10
Prognostic value of secretoneurin in chronic heart failure. Data from the GISSI-Heart Failure trial	9
Reducing unnecessary free thyroid hormone testing by the reinforcement of a reflexive algorithm in an outpatient environment	9
Editorial Board	9
Current status of therapeutic drug monitoring for methotrexate, imatinib, paclitaxel in China	9
Amikacin therapeutic drug monitoring: Evaluation of therapy performance and analytical techniques in a developing country setting	9
Elevated urine norepinephrine levels and alcohol use: A relationship that should be not neglected	9
Detection of 58 fentanyl analogs using ARK fentanyl II and Immunalysis fentanyl immunoassays	9
Vascular endothelial growth factor A, a potential non-invasive biomarker for metabolic dysfunction-associated steatotic liver disease progression	9
Methods for determining clinical utility	9
Demonstration of equivocal anti-glomerular basement membrane antibody positivity as a non-specific reaction through multiple immunologic assays in a case of pediatric asymptomatic hematuria	9
Using differential mobility spectrometry to improve the specificity of targeted measurements of 2,3-dinor 11β-Prostaglandin F2α	9
Impact of lot-to-lot variation in absolute neutrophil count measured by a point-of-care device in patients receiving clozapine treatment	8

Estimation formulas for ionized magnesium in critically ill children	8
A tale of two variants: The first reported case of hemoglobin Rush and hemoglobin S in a compound heterozygote	8
Towards achieving the end of the HIV epidemic: Advances, challenges and scaling-up strategies	8
A rebuttal to: A letter to editor entitled: “A panel (CA19-9, CEA and PIVKA-II) of serum markers for pancreatic cancer diagnosis”	8
Huge discrepancy between serum immunoglobulin concentration and proteinemia due to heavy chain disease	8
HER2 gene mutations and matrix biomarkers in breast cancer	8
Autoverification-based algorithms to detect preanalytical errors: Two examples	8
Evaluation of three NT-proBNP assays for heart failure	8
Canadian guidance for diagnosis and management of acute hepatic porphyrias	8
Rethinking research funding through a sustainability Lens	8
Secretoneurin is not associated with cardiovascular events or mortality in patients treated with hemodialysis: A prospective multicenter cohort study	8
Editorial Board	8
Pediatric ionized calcium reference intervals from archived radiometer data	8
Clinical concordance assessment should be an integral component of laboratory method comparison studies: A regression transference of routine clinical data approach	8
Change in cardiac troponin T to differentiate acute from chronic myocardial injury in the Emergency Department	8
Repression of miR-146a in predicting poor treatment outcome in triple-negative breast cancer	7
Laboratory reflex testing strategy for the early identification of primary care patients with multiple myeloma	7
Elevated level of platelet factor 4 in follicular fluid is associated with polycystic ovary syndrome	7
The importance of SII and FIB-4 scores in predicting mortality in idiopathic pulmonary fibrosis patients	7
Corrigendum to “The biological diagnosis of Alzheimer’s disease using blood-based biomarkers: A Canadian prospective” [Clin. Biochem. 139 (2025); pages 1–17 /110980]	7
Inflammatory markers and their association with preeclampsia among pregnant women: A systematic review and meta-analysis	7
Bias in IGF-1 concentrations and interpretation across three different clinical laboratory assays	7
Krebs von den Lungen-6 (KL-6) as a diagnostic marker for pulmonary fibrosis: A systematic review and meta-analysis	7
The CDKN2A/B rs10811661 polymorphism is associated with metabolic syndrome, insulin resistance, and lipid levels in individuals with obesity and impaired fasting glucose	7
Editorial Board	7
Carrier frequency and molecular basis of hemoglobinopathies among blood donors in eastern Morocco: Implications for blood donation and genetic diagnosis	7
Biotinidase activity is affected by both seasonal temperature and filter collection cards	7
A new assay falsely increases lactate dehydrogenase in plasma but not in serum	7
Minimal mathematical model for glycation of albumin	7
Serum extracellular vesicles with NSD1 and FBXO7 mRNA as novel biomarkers for gastric cancer	7
Are discordant cTnI results detected in an analytical comparison clinically irrelevant?	7
Less is more: minimum sample volume for the free phenytoin assay on the Roche Cobas c503 analyzer	7
Biomarker profiling for infection diagnosis in emergency departments: A diagnostic study evaluating C-reactive protein, procalcitonin, Club Cell Protein 16, interleukin-6, chitinase-like protein, and	7
Phenotyping and genotyping for the dihydropyrimidine dehydrogenase test in Italy: a precise diagnostic strategy to detect rare variants and improve drug administration	7
Construction of a multi-classified decision tree model for identifying malignant pleural effusion and tuberculous pleural effusion	7
Serum human epididymis protein 4 is associated with disease severity in patients with IgA nephropathy	7
Characterizing M-protein light chain glycosylation via mass spectrometry	7
Expression profile of long-noncoding RNAs MIR31HG, NKILA, and PACER in systemic lupus erythematosus patients	7
Freelite and Kloneus assays in free light chain measurements in patients with renal impairment	7
In vivo and in vitro relationship between ionized magnesium and ionized calcium	7
The potential of anti-glutamic acid decarboxylase antibodies to support a diagnosis of autoimmune diabetes mellitus	6
Innovations in infectious disease diagnostics	6
Agreement of LC-MS assays for IGF-1 traceable to NIST and WHO standards permits harmonization of reference intervals between laboratories	6
Diagnostic performance of a rapid, novel, whole blood, point of care high-sensitivity cardiac troponin I assay for myocardial infarction	6
Lack of interference of metronidazole with Roche cobas c502 and c702 chemistry tests	6
Comparison of mean platelet component and mean platelet mass in immune thrombocytopenia versus hypoproductive thrombocytopenias	6
Serial secretoneurin measurement and risk of ventricular arrhythmias and death in patients with left ventricular systolic dysfunction	6
Evaluation of Siemens Atellica AMH assay and comparison with Roche, Beckman and Ansh Labs	6
Editorial Board	6
Public knowledge of SARS-CoV-2 serological and viral lineage laboratory testing and result interpretation: A GENCOV study cross-sectional survey	6
Accuracy of determination of free light chains (Kappa and Lambda) in plasma and serum by Swedish laboratories as monitored by external quality assessment	6
Innovations in infectious disease testing: Leveraging COVID-19 pandemic technologies for the future	6
MELAS a clinically and genetically heterogeneous syndrome	6
Investigating angiogenin/ribonuclease 5 as a diagnostic biomarker for bladder cancer: In-depth analysis from a systematic review and meta-analysis	6
Primer Part 1 − Preparing a laboratory quality improvement project	6
Establishing sustainable quality improvement in the clinical laboratory: Redesign of the total testing process and digital transformation of routine quality assurance activities	6
Methods of the ivota triAl of he Atellica VTLi point of care emergenc de artment high sensitivity troponin eval ation	6
Plasma levels of bone morphogenic protein-4 are downregulated in elderly hypertensive patients with heart failure with preserved ejection fraction	6
Qualitative and quantitative detection of SARS-CoV-2 antibodies from dried blood spots	6
Evaluation of an automated assay for eosinophil-derived neurotoxin in serum	6
Implementing minimal request intervals for laboratory tests: a utilization management study across eight hospitals in South Iran	6
Altered plasma levels of apixaban in major gastrointestinal tract surgery: A case report and review of the literature	6
Therapeutic drug monitoring of levetiracetam – Is dried blood spot sampling suitable?	6
More about the random uncertainty of photometric determination of hemolysis index on the Abbott Alinity c platform	5
Letter to the Editor: On moving average and internal quality control	5
The performance of Carbohydrate Antigen 125-Thomsen-nouveau and anti-Müllerian hormone combined with CA125, Human epididymis protein 4 and Risk of Malignancy Algorithm in diagnosis for patients with E	5
Ethnicity and sex-specific 99th percentile upper reference limits of high-sensitivity cardiac troponin I among adults in Xinjiang, China	5
The biological diagnosis of Alzheimer’s disease using blood-based biomarkers: A Canadian prospective	5
Two SARS-CoV-2 serology assays detect antibodies in the sera of individuals diagnosed with SARS-CoV-2 Omicron variant	5
Kinetics of d-lactate and ischemia-modified albumin after abdominal aortic surgery and their ability to predict intestinal ischemia	5
A novel and robust analytical method for the quantification of perospirone in human plasma using an LC–MS/MS system with self-internal standard calibration	5
An improved and economical LLE-LC/MS method for quantifying phosphatidylethanol: Identification and separation of isotopic cross-talk in clinical alcohol testing	5
Urine proteome uncovers common mechanisms between mucopolysaccharidosis types I and II	5
Factors influencing creatine kinase-MM concentrations in newborns and implications for newborn screening for Duchenne muscular dystrophy	5
Advances in molecular infectious diseases testing in the time of COVID-19	5
Clinically relevant urine creatinine underestimation in the low concentration range on the Siemens Dimension Vista®	5
Editorial Board	5
Spirited away: Can ethanol testing in add-on orders provide meaningful results?	5
Phenotypic expression of the m.3243A > G variant not only depends on heteroplasmy or haplotype	5
Increased serum SGLT2 and its potential diagnostic and prognostic value in patients with acute ischemic stroke	5

Selected abstracts presented at the annual conference of the Canadian Society of Clinical Chemists (CSCC), 2023	5
Medical appropriateness and economics of nucleic acid amplification testing for infectious diseases	5
Advantages and application of a decision tree algorithm combined with the Harris-Boyd criterion in the construction of dynamic reference intervals for coagulation indicators during pregnancy	5
Dose optimization and target attainment of vancomycin in children	5
Long-term follow-up with a clinical decision support system based on laboratory reports to manage patients with biochemical recurrence after radical prostatectomy	5
Functional characterization of the p.(Gln195His) or Tainan and novel p.(Ser184Cys) or Toluca glucose-6-phosphate dehydrogenase (G6PD) gene natural variants identified through Mexican newborn screening	5