OOIR: Observatory of International Research

Papers

(The TQCC of Clinical and Experimental Immunology is 9. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-06-01 to 2026-06-01.)

Article	Citations
Correction to: Type 1 interferon auto-antibodies are elevated in patients with decompensated liver cirrhosis	118
HLA-DR expressing lymph node fibroblasts maintain FoxP3+ regulatory T cells and are reduced in rheumatoid arthritis	88
Destined for the intestine: thymic selection of TCRαβ CD8αα intestinal intraepithelial lymphocytes	70
Correction to: Cisplatin-mediated down-regulation of miR-145 contributes to up-regulation of PD-L1 via the c-Myc transcription factor in cisplatin-resistant ovarian carcinoma cells	70
Human in vitro-induced IL-17A+ CD8+ T-cells exert pro-inflammatory effects on synovial fibroblasts	55
Panobinostat enhances NK cell cytotoxicity in soft tissue sarcoma	55
Gingival transcriptomic patterns of macrophage polarization during initiation, progression, and resolution of periodontitis	50
The alteration of mucosal bile acid profile is associated with nerve growth factor expression in mast cells and bowel symptoms in diarrhea-predominant irritable bowel syndrome	50
Regulatory T cells in inflamed liver are dysfunctional in murine primary biliary cholangitis	49
Development of a score derived from full blood count parameters to differentiate individuals with tuberculosis disease from those with tuberculosis infection	47
Secretory-IgA binding to intestinal microbiota attenuates inflammatory reactions as the intestinal barrier of preterm infants matures	44
Defining the cross-reactivity between peanut allergens Ara h 2 and Ara h 6 using monoclonal antibodies	44
Cytokine production by human B cells: role in health and autoimmune disease	42
Diagnostic accuracy of saliva-based testing as a Vibrio cholerae surveillance tool among naturally infected patients	42
The effect of immunomodulatory therapy with recombinant human interferon alpha-2β on blood cytokine levels in children with recurrent episodes of acute obstructive bronchitis	39
Investigating immune profile by CyTOF in patients with eosinophilic esophagitis after treatment with orodispersible budesonide	39
C/EBPε and its acetylation in PMN enhance the tolerance to trauma	32
Primary graft dysfunction after Lung transplantation: unveiling the role of innate immunity	30
Exploring S100A8/A9, neopterin, and MMP3 in familial Mediterranean fever	29
Periapical lesion following Cnm-positiveStreptococcus mutanspulp infection worsens cerebral hemorrhage onset in an SHRSP rat model	28
Reduced response to SARS-CoV-2 vaccination is associated with impaired immunoglobulin class switch recombination in SLE patients	28
Immune profiling reveals umbilical cord blood mononuclear cells from South India display an IL-8 dominant, CXCL-10 deficient polyfunctional monocyte response to pathogen-associated molecular patterns	28
Neutrophil extracellular traps in rheumatoid arthritis: biomarkers, drivers, and emerging therapeutic targets	27
Phenotypic and functional characteristics of highly differentiated CD57+NKG2C+ NK cells in HIV-1-infected individuals	26
Human genetics of responses to vaccines	25

Differentiating between activation via the lectin or the classical complement pathway in patients with systemic lupus erythematosus	24
Amlexanox targeted inhibition of TBK1 regulates immune cell function to exacerbate DSS-induced inflammatory bowel disease	24
IL-38 alleviates airway remodeling in chronic asthma via blocking the profibrotic effect of IL-36γ	23
The B-cells paradigm in systemic sclerosis: an update on pathophysiology and B-cell-targeted therapies	23
Correction to: Discrepancy in clinical and laboratory profiles of NMOSD patients between AQP4 antibody positive and negative: can NMOSD be diagnosed without AQP4 antibody?	22
Immune versatility of oral keratinocytes: from barrier integrity to inflammation control—a mini review	22
NRF1 knockdown alleviates lipopolysaccharide-induced pulmonary inflammatory injury by upregulating DKK3 and inhibiting the GSK-3β/β-catenin pathway	22
Editor’s Note: Porins and lipopolysaccharide from Salmonella typhimurium induce leucocyte transmigration through human endothelial cells	21
Introducing our new series: Clinical and Experimental Treatment of…	21
Essential role of interferon-regulatory factor 4 in regulating diabetogenic CD4+ T and innate immune cells in autoimmune diabetes in NOD mice	21
NK-cell receptor modulation in viral infections	20
The CXCL10-CXCR3 axis plays an important role in Kawasaki disease	20
Children with recurrent infections: perspective of immunoglobulin G subclasses deficiency and impaired specific antibody responses	20
Systemic sclerosis and primary biliary cholangitis share an antibody population with identical specificity	19
Inborn errors of immunity-related immunological mechanisms and pharmacological therapy alternatives in periodontitis	18
Ethnic differences in complement system biomarkers and their association with metabolic health in men of Black African and White European ethnicity	18
Surface protein and functional analyses identify CD4+CD39+ TCR αβ+ and activated TCR Vδ1+ cells with distinct pro-inflammatory functions in Crohn’s disease lesions	17
The longitudinal loss of islet autoantibody responses from diagnosis of type 1 diabetes occurs progressively over follow-up and is determined by low autoantibody titres, early-onset, and genetic varia	17
Inborn errors of immunity: the Goldilocks effect—susceptibility to disease due to a little too much or a little too little	17
From T-cell defect to tumorigenesis: Epstein–Barr virus–associated smooth muscle tumors in ITK deficiency	17
Elevated expression of TAM receptor tyrosine kinase in synovial fluid and synovial tissue of rheumatoid arthritis	16
Identifying platelet-derived factors as amplifiers ofB. burgdorferi-induced cytokine production	16
Hyperosmolar environment and salivary gland epithelial cells increase extra-cellular matrix remodeling and lymphocytic infiltration in Sjögren’s syndrome	16
A study of changes in hematologic parameters in patients with migraine	15
Cholesteatoma- an Immune disease	15
A close-up on the expanding landscape of CD21–/low B cells in humans	15
The pathogenesis of multiple sclerosis: a series of unfortunate events	15
Higher humoral response in ileal versus colonic Crohn’s disease	15
Depletion and recovery of IgG following treatment with an anti-FcRn antibody and IdeS in pigtail macaques	15
Pneumococcal serotype-specific antibodies in children with recurrent oto-sinopulmonary infections	15
Regulatory T cells in autoimmune primary adrenal insufficiency	15
Yeast β-glucan modulates macrophages and improves antitumor NK-cell responses in cancer	15
The role of extracellular vesicle immune checkpoints in cancer	15
Coexistence of apoptosis, pyroptosis, and necroptosis pathways in celiac disease	14
IL-33 blockade attenuates vascular inflammation in a mouse model of Kawasaki disease vasculitis	14
Identification of angiogenesis-related genes and molecular subtypes for psoriasis based on random forest algorithm	14
Harnessing the power of memory-like NK cells to fight cancer	14
Exposure to gestational diabetes mellitus increases subclinical inflammation mediated in part by obesity	14
Time to treat the climate and nature crisis as one indivisible global health emergency	14
Increased expression of complement C3c, iC3b, and cells containing CD11b or CD14 in experimentally induced psoriatic lesion	13
Acute hepatitis of unknown aetiology in children: a clinical update on the recent outbreak with mechanistic insights	13
Diagnostic markers and potential therapeutic agents for Sjögren’s syndrome screened through multiple machine learning and molecular docking	13
CD40L and IL-4 lymph node-associated signals protect B cells from rituximab-induced ADCC via KIR and NKG2A	13
Proteomic analysis reveals dysregulation of peripheral blood neutrophils in patients with Multiple Sclerosis	13
Restoration of the lamina propria duodenal immune infiltrate in gluten-free diet treated celiac patients despite persistent villous atrophy	13
Immune cell composition and inflammatory profile of human peri-implantitis and periodontitis lesions	13
The pathophysiology of hemophagocytic lympho-histiocytosis (HLH) syndrome and insights from animal models	13
Pirfenidone alleviates interstitial lung disease in mice by inhibiting neutrophil extracellular trap formation and NLRP3 inflammasome activation	13
Preparation of mesoporous silica nanocarriers targeting glucose-6-phosphate isomerase inhibition and application in the treatment of rheumatoid arthritis	13
Natural killer cells and innate lymphoid cells but not NKT cells are mature in their cytokine production at birth	13

Learning from inborn errors of immunity and secondary immune deficiencies about vaccine immunogenicity, efficacy, and safety	13
Increased expression of CXCL10 and CCL3 salivary gland chemokines in primary Sjögren’s syndrome detected and systematically quantified using RNAscope®in situ hybridization	13
Effects of mesenchymal stem cells on Treg cells in rats with colitis	12
Persistence of the immune response after two doses of ChAdOx1 nCov-19 (AZD1222): 1 year of follow-up of two randomized controlled trials	12
Multiomics analysis of neutrophils in SLE: insights from adult and paediatric disease	12
2B4: A potential target in Staphylococcus aureus associated allergic inflammation	12
The immune landscape of the inflamed joint defined by spectral flow cytometry	12
Application of whole-exome sequencing to predict inborn errors of immunity in pediatric severe infections and sepsis	12
HTNV infection induces activation and deficiency of CD8+MAIT cells in HFRS patients	12
Tocilizumab suppresses NF-kappa B activation via toll-like receptor 9 signaling by reducing cell-free DNA in rheumatoid arthritis	12
Response to Letter to the Editor: Type 2 diabetes is associated with the accumulation of senescent T cells	12
Complement factors as biomarkers in ANCA-associated vasculitis in remission	12
Distinctive T-cell receptor repertoire in paediatric inflammatory multisystem syndrome temporally associated with coronavirus disease 2019/multisystem inflammatory syndrome in children patients: possi	12
Inborn errors of immunity with loss- and gain-of-function germline mutations in STAT1	11
Difference in respiratory syncytial virus-specific Fc-mediated antibody effector functions between children and adults	11
Concurrent central nervous system infection with Candida and Mycobacterium intracellulare in CARD9 deficie	11
Nck1 regulates the in vitro development of human regulatory T cells through AKT pathway	11
Eosinophils ETosis as a novel contributor to the pathogenesis of granulomatosis with polyangiitis	11
Parallel origins and functions of T cells and ILCs	11
COVID-19 infection and vaccination in immunodeficiency	11
Serum Metrnl as a potential biomarker for renal involvement in ANCA-associated vasculitis	11
Discovery and Phase 1 study of a novel monoclonal antibody against human IL-1β for the treatment of IL-1β-mediated diseases	11
Expanded senescent CD8 T cells in IMID patients are associated with distinct inflammatory cytokines	11
Altered CD226/TIGIT expressions were associated with NK phenotypes in primary antiphospholipid syndrome and affected by IL-4/JAK pathway	10
Multi-dimensional analysis of B cells reveals the expansion of memory and regulatory B-cell clusters in humans living in rural tropical areas	10
Autoimmune/inflammatory syndrome induced by adjuvants (ASIA): past, present, and future implications	10
Investigating concomitant RAG-2 and LRBA mutations in SCID and autoimmunity	10
What do we know about co-stimulatory and co-inhibitory immune checkpoint signals in ankylosing spondylitis?	10
Engaging PD-1 rescuesregulatory T cell function and inhibits inflammatory T cells in rheumatoid arthritis	10
A novel fusion protein reduces kidney complement in experimental C3 glomerulopathy	10
Unraveling complement activation profiles on endothelial cells in healthy donors using an ex vivo model	10
My highlights as Editor-in-Chief of Clinical & Experimental Immunology, 2017–2024	10
Anti-glutathione S-transferase omega 1-1 (GSTO1-1) antibodies are increased during acute and chronic inflammation in humans	10
Follow-up of immune response in patients with common variable immunodeficiency following SARS-CoV-2 vaccination	10
Immunometabolism crosstalk between regulatory T cells and glucose homeostasis of type 1 diabetes	10
In vitro pharmacological modulation of NKG2D expression in immune cells from Behçet syndrome patients	10
Regulatory T-cell frequency and function in acute myocardial infarction patients and its correlation with ventricular dysfunction	10
A novel monoclonal antibody with improved FcγR blocking ability demonstrated non-inferior efficacy compared to IVIG in cynomolgus monkey ITP model at considerably lower dose	9
Unveiling WHIM syndrome: Mavorixafor’s emerging role in immune restoration and therapy	9
MASP2 inhibition by narsoplimab suppresses endotheliopathies characteristic of transplant-associated thrombotic microangiopathy:in vitroandex vivoevidence	9
Immunophenotyping of apparently immunocompetent hosts with cryptococcosis reveals IL-17 deficiency as a unifying susceptibility factor	9
Catalase inhibition can modulate the ability of peripheral blood T cells to undergo apoptosis in Crohn’s disease	9
Gene expression analysis revealed downregulation of complement receptor 1 in clonal B cells in cold agglutinin disease	9
Human FCHO1 deficiency: review of the literature and additional two cases	9
From acute lung injury to cerebral ischemia: a unified concept involving intercellular communication through extracellular vesicle-associated miRNAs released by macrophages/microglia	9
Practical challenges for functional validation of STAT1 gain of function genetic variants	9
sB7-H4 is a diagnostic biomarker in epithelial ovarian cancer and correlates to platinum resistance	9
Environmental pollutant 3-methyl-4-nitrophenol promotes the expression of oncostatin M to exacerbate airway allergic inflammation	9
Leucine-rich repeat kinase 2 promotes the development of experimental severe acute pancreatitis	9
CD137 deficiency patients: two new patients and review of the literature	9
Neutrophil depletion attenuates antibody-mediated rejection in a renal transplantation mouse model	9