OOIR: Observatory of International Research

Papers

(The TQCC of Clinical and Experimental Immunology is 9. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-11-01 to 2025-11-01.)

Article	Citations
Correction to: Type 1 interferon auto-antibodies are elevated in patients with decompensated liver cirrhosis	83
The alteration of mucosal bile acid profile is associated with nerve growth factor expression in mast cells and bowel symptoms in diarrhea-predominant irritable bowel syndrome	59
Secretory-IgA binding to intestinal microbiota attenuates inflammatory reactions as the intestinal barrier of preterm infants matures	58
Cytokine production by human B cells: role in health and autoimmune disease	49
Panobinostat enhances NK cell cytotoxicity in soft tissue sarcoma	49
Gingival transcriptomic patterns of macrophage polarization during initiation, progression, and resolution of periodontitis	48
HLA-DR expressing lymph node fibroblasts maintain FoxP3+ regulatory T cells and are reduced in rheumatoid arthritis	48
Identification of ANXA2 on epithelial cells as a new receptor for secretory IgA using immunoprecipitation and mass spectrometry	47
Correction to: Cisplatin-mediated down-regulation of miR-145 contributes to up-regulation of PD-L1 via the c-Myc transcription factor in cisplatin-resistant ovarian carcinoma cells	43
Human in vitro-induced IL-17A+ CD8+ T-cells exert pro-inflammatory effects on synovial fibroblasts	40
Defining the cross-reactivity between peanut allergens Ara h 2 and Ara h 6 using monoclonal antibodies	39
Extracellular vesicles containing PD-L1 contribute to CD8+ T-cell immune suppression and predict poor outcomes in small cell lung cancer	37
Regulatory T cells in inflamed liver are dysfunctional in murine primary biliary cholangitis	36
The PPAR-γ agonist pioglitazone exerts proinflammatory effects in bronchial epithelial cells during acute Pseudomonas aeruginosa pneumonia	35
Destined for the intestine: thymic selection of TCRαβ CD8αα intestinal intraepithelial lymphocytes	34
The B-cells paradigm in systemic sclerosis: an update on pathophysiology and B-cell-targeted therapies	33
Outcomes following SARS-CoV-2 infection in patients with primary and secondary immunodeficiency in the UK	33
Diagnostic accuracy of saliva-based testing as a Vibrio cholerae surveillance tool among naturally infected patients	32
C/EBPε and its acetylation in PMN enhance the tolerance to trauma	32
Human genetics of responses to vaccines	31
Periapical lesion following Cnm-positiveStreptococcus mutanspulp infection worsens cerebral hemorrhage onset in an SHRSP rat model	30
Exploring S100A8/A9, neopterin, and MMP3 in familial Mediterranean fever	30
Immune profiling reveals umbilical cord blood mononuclear cells from South India display an IL-8 dominant, CXCL-10 deficient polyfunctional monocyte response to pathogen-associated molecular patterns	28
Investigating immune profile by CyTOF in patients with eosinophilic esophagitis after treatment with orodispersible budesonide	27
Exposure of female NZBWF1 mice to imiquimod-induced lupus nephritis at an early age via a unique mechanism that differed from spontaneous onset	27

Differentiating between activation via the lectin or the classical complement pathway in patients with systemic lupus erythematosus	25
The effect of immunomodulatory therapy with recombinant human interferon alpha-2β on blood cytokine levels in children with recurrent episodes of acute obstructive bronchitis	25
Molecular neuroimaging of inflammation in HIV	25
IgLON5 autoimmunity tested positive in patients with isolated chronic insomnia disease	24
Immunotherapeutic targeting of activating natural killer cell receptors and their ligands in cancer	24
Phenotypic and functional characteristics of highly differentiated CD57+NKG2C+ NK cells in HIV-1-infected individuals	23
Primary graft dysfunction after Lung transplantation: unveiling the role of innate immunity	23
Amlexanox targeted inhibition of TBK1 regulates immune cell function to exacerbate DSS-induced inflammatory bowel disease	23
Exosomal PD-L1 predicts response with immunotherapy in NSCLC patients	23
IL-38 alleviates airway remodeling in chronic asthma via blocking the profibrotic effect of IL-36γ	23
Patho-immunological mechanisms of vitiligo: the role of the innate and adaptive immunities and environmental stress factors	22
Immune versatility of oral keratinocytes: from barrier integrity to inflammation control — A Mini Review	22
NRF1 knockdown alleviates lipopolysaccharide-induced pulmonary inflammatory injury by upregulating DKK3 and inhibiting the GSK-3β/β-catenin pathway	20
Heterosubtypic, cross-reactive immunity to human Cytomegalovirus glycoprotein B	20
NK-cell receptor modulation in viral infections	20
Reduced response to SARS-CoV-2 vaccination is associated with impaired immunoglobulin class switch recombination in SLE patients	20
Correction to: Discrepancy in clinical and laboratory profiles of NMOSD patients between AQP4 antibody positive and negative: can NMOSD be diagnosed without AQP4 antibody?	19
The CXCL10-CXCR3 axis plays an important role in Kawasaki disease	19
Children with Recurrent Infections: Perspective of Immunoglobulin G Subclasses Deficiency and Impaired Specific Antibody Responses	18
Inborn errors of immunity-related immunological mechanisms and pharmacological therapy alternatives in periodontitis	18
Introducing our new series: Clinical and Experimental Treatment of…	17
Essential role of interferon-regulatory factor 4 in regulating diabetogenic CD4+ T and innate immune cells in autoimmune diabetes in NOD mice	17
Systemic sclerosis and primary biliary cholangitis share an antibody population with identical specificity	17
Clinical significance of differential serum-signatures for early prediction of severe dengue among Eastern Indian patients	17
Inborn errors of immunity: the Goldilocks effect—susceptibility to disease due to a little too much or a little too little	16
Ethnic differences in complement system biomarkers and their association with metabolic health in men of Black African and White European ethnicity	16
The longitudinal loss of islet autoantibody responses from diagnosis of type 1 diabetes occurs progressively over follow-up and is determined by low autoantibody titres, early-onset, and genetic varia	16
Editor’s Note: Porins and lipopolysaccharide from Salmonella typhimurium induce leucocyte transmigration through human endothelial cells	16
Surface protein and functional analyses identify CD4+CD39+ TCR αβ+ and activated TCR Vδ1+ cells with distinct pro-inflammatory functions in Crohn’s disease lesions	15
Increased levels of pathogenic Th17 cells and diminished function of CD69+ Treg lymphocytes in patients with overweight	15
Interleukin 17 receptor E identifies heterogeneous T helper 17 cells in peritoneal fluid of moderate and severe endometriosis patients	15
Coexistence of apoptosis, pyroptosis, and necroptosis pathways in celiac disease	15
CMTM6: increased circulating level and up-regulated expression in labial salivary glands in patients with primary Sjogren’s syndrome	15
Regulatory T cells in autoimmune primary adrenal insufficiency	15
Pneumococcal serotype-specific antibodies in children with recurrent oto-sinopulmonary infections	15
Hyperosmolar environment and salivary gland epithelial cells increase extra-cellular matrix remodeling and lymphocytic infiltration in Sjögren’s syndrome	15
The effect of short-chain fatty acids on M2 macrophages polarizationin vitroandin vivo	14
Yeast β-glucan modulates macrophages and improves antitumor NK-cell responses in cancer	14
Evaluation of a fit-for-purpose assay to monitor antigen-specific functional CD4+ T-cell subpopulations in rheumatoid arthritis using flow cytometry–based peptide-MHC class-II tetramer staining	14
Elevated expression of TAM receptor tyrosine kinase in synovial fluid and synovial tissue of rheumatoid arthritis	14
The role of extracellular vesicle immune checkpoints in cancer	14
Exposure to gestational diabetes mellitus increases subclinical inflammation mediated in part by obesity	14
A study of changes in hematologic parameters in patients with migraine	14
A close-up on the expanding landscape of CD21–/low B cells in humans	14
Identifying platelet-derived factors as amplifiers ofB. burgdorferi-induced cytokine production	14
Identification of angiogenesis-related genes and molecular subtypes for psoriasis based on random forest algorithm	13
Proteomic analysis reveals dysregulation of peripheral blood neutrophils in patients with Multiple Sclerosis	13
Time to treat the climate and nature crisis as one indivisible global health emergency	13
The pathogenesis of multiple sclerosis: a series of unfortunate events	13
Diagnostic markers and potential therapeutic agents for Sjögren’s syndrome screened through multiple machine learning and molecular docking	13

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Increased expression of CXCL10 and CCL3 salivary gland chemokines in primary Sjögren’s syndrome detected and systematically quantified using RNAscope®in situ hybridization	13
Pirfenidone alleviates interstitial lung disease in mice by inhibiting neutrophil extracellular trap formation and NLRP3 inflammasome activation	13
The pathophysiology of hemophagocytic lympho-histiocytosis (HLH) syndrome and insights from animal models	12
Droplet digital PCR for identifying copy number variations in patients with primary immunodeficiency disorders	12
Autophagy modulation in multiple sclerosis and experimental autoimmune encephalomyelitis	12
Induction of memory-like CD8+ T cells and CD4+ T cells from human naive T cells in culture	12
Preparation of mesoporous silica nanocarriers targeting glucose-6-phosphate isomerase inhibition and application in the treatment of rheumatoid arthritis	12
Learning from inborn errors of immunity and secondary immune deficiencies about vaccine immunogenicity, efficacy, and safety	12
Patients diagnosed with COVID-19 and treated with anakinra: a real-world study in the USA	12
Harnessing the power of memory-like NK cells to fight cancer	12
Immune cell composition and inflammatory profile of human peri-implantitis and periodontitis lesions	12
Increased expression of complement C3c, iC3b, and cells containing CD11b or CD14 in experimentally induced psoriatic lesion	11
Tocilizumab suppresses NF-kappa B activation via toll-like receptor 9 signaling by reducing cell-free DNA in rheumatoid arthritis	11
The immune landscape of the inflamed joint defined by spectral flow cytometry	11
Acute hepatitis of unknown aetiology in children: a clinical update on the recent outbreak with mechanistic insights	11
2B4: A potential target in Staphylococcus aureus associated allergic inflammation	11
Effects of mesenchymal stem cells on Treg cells in rats with colitis	11
Natural killer cells and innate lymphoid cells but not NKT cells are mature in their cytokine production at birth	11
HTNV infection induces activation and deficiency of CD8+MAIT cells in HFRS patients	11
Difference in respiratory syncytial virus-specific Fc-mediated antibody effector functions between children and adults	11
Discovery and Phase 1 study of a novel monoclonal antibody against human IL-1β for the treatment of IL-1β-mediated diseases	10
Innate stimulation of B cells ex vivo enhances antibody secretion and identifies tumour-reactive antibodies from cancer patients	10
The TOX subfamily: all-round players in the immune system	10
Parallel origins and functions of T cells and ILCs	10
Distinctive T-cell receptor repertoire in paediatric inflammatory multisystem syndrome temporally associated with coronavirus disease 2019/multisystem inflammatory syndrome in children patients: possi	10
Complement factors as biomarkers in ANCA-associated vasculitis in remission	10
Restoration of the lamina propria duodenal immune infiltrate in gluten-free diet treated celiac patients despite persistent villous atrophy	10
Persistence of the immune response after two doses of ChAdOx1 nCov-19 (AZD1222): 1 year of follow-up of two randomized controlled trials	10
Response to Letter to the Editor: Type 2 diabetes is associated with the accumulation of senescent T cells	10
Application of whole-exome sequencing to predict inborn errors of immunity in pediatric severe infections and sepsis	10
Inborn errors of immunity with loss- and gain-of-function germline mutations in STAT1	10
COVID-19 infection and vaccination in immunodeficiency	10
Expanded senescent CD8 T cells in IMID patients are associated with distinct inflammatory cytokines	9
Engaging PD-1 rescuesregulatory T cell function and inhibits inflammatory T cells in rheumatoid arthritis	9
MASP2 inhibition by narsoplimab suppresses endotheliopathies characteristic of transplant-associated thrombotic microangiopathy:in vitroandex vivoevidence	9
Unveiling WHIM syndrome: Mavorixafor’s emerging role in immune restoration and therapy	9
Autoimmune/inflammatory syndrome induced by adjuvants (ASIA): past, present, and future implications	9
Leucine-rich repeat kinase 2 promotes the development of experimental severe acute pancreatitis	9
SR-A neutralizing antibody: potential drug candidate for ameliorating osteoclastogenesis in rheumatoid arthritis	9
Genetic correlation between thyroid hormones and Parkinson’s disease	9
Regulatory T-cell frequency and function in acute myocardial infarction patients and its correlation with ventricular dysfunction	9
Anti-glutathione S-transferase omega 1-1 (GSTO1-1) antibodies are increased during acute and chronic inflammation in humans	9
Leptin-reactive antibodies are distinctly correlated with body composition parameters and metabolic risk indexes in children and adolescents	9
Investigating Concomitant RAG-2 and LRBA Mutations in SCID and Autoimmunity	9
Catalase inhibition can modulate the ability of peripheral blood T cells to undergo apoptosis in Crohn’s disease	9
Environmental pollutant 3-methyl-4-nitrophenol promotes the expression of oncostatin M to exacerbate airway allergic inflammation	9
Gene expression analysis revealed downregulation of complement receptor 1 in clonal B cells in cold agglutinin disease	9
Altered CD226/TIGIT expressions were associated with NK phenotypes in primary antiphospholipid syndrome and affected by IL-4/JAK pathway	9
What do we know about co-stimulatory and co-inhibitory immune checkpoint signals in ankylosing spondylitis?	9
Nck1 regulates the in vitro development of human regulatory T cells through AKT pathway	9
Follow-up of immune response in patients with common variable immunodeficiency following SARS-CoV-2 vaccination	9
Human FCHO1 deficiency: review of the literature and additional two cases	9
Immunophenotyping of apparently immunocompetent hosts with cryptococcosis reveals IL-17 deficiency as a unifying susceptibility factor	9
Practical challenges for functional validation of STAT1 gain of function genetic variants	9
My highlights as Editor-in-Chief of Clinical & Experimental Immunology, 2017–2024	9
Multi-dimensional analysis of B cells reveals the expansion of memory and regulatory B-cell clusters in humans living in rural tropical areas	9