OOIR: Observatory of International Research

Papers

(The TQCC of Clinical and Experimental Immunology is 7. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-11-01 to 2024-11-01.)

Article	Citations
Keratinocytes: innate immune cells in atopic dermatitis	91
Roles of cytokines and T cells in the pathogenesis of myasthenia gravis	75
Innate and adaptive immune responses to SARS-CoV-2 in humans: relevance to acquired immunity and vaccine responses	66
Establishing the prevalence of common tissue-specific autoantibodies following severe acute respiratory syndrome coronavirus 2 infection	54
Double-negative (DN) B cells: an under-recognized effector memory B cell subset in autoimmunity	48
Therapeutic vaccination for treatment of chronic hepatitis B	47
Comprehensive comparison between 222 CTLA-4 haploinsufficiency and 212 LRBA deficiency patients: a systematic review	44
The role of interleukin-18 in the diagnosis and monitoring of hemophagocytic lymphohistiocytosis/macrophage activation syndrome – a systematic review	41
Does CCL19 act as a double-edged sword in cancer development?	37
IL-2-based approaches to Treg enhancement	36
Human CD4+ T cells specific for dominant epitopes of SARS-CoV-2 Spike and Nucleocapsid proteins with therapeutic potential	34
MiR-223-3p inhibits inflammation and pyroptosis in monosodium urate-induced rats and fibroblast-like synoviocytes by targeting NLRP3	33
The effect of short-chain fatty acids on M2 macrophages polarizationin vitroandin vivo	32
Clinical and neuroimaging findings in MOGAD–MRI and OCT	32
A myriad of roles of dendritic cells in atherosclerosis	31
Lymphocyte subsets early predict mortality in a large series of hospitalized COVID-19 patients in Spain	31
Gut microbiome and autoimmune disorders	30
Inborn errors of human IKAROS: LOF and GOF variants associated with primary immunodeficiency	29
Towards PET imaging of the dynamic phenotypes of microglia	28
Immunological findings in patients with migraine and other primary headaches: a narrative review	27
Extracellular vesicles containing PD-L1 contribute to CD8+ T-cell immune suppression and predict poor outcomes in small cell lung cancer	27
Reconnaissance of tumor immune microenvironment spatial heterogeneity in metastatic renal cell carcinoma and correlation with immunotherapy response	26
Arthritis in systemic lupus erythematosus is characterized by local IL-17A and IL-6 expression in synovial fluid	26
Neuroinflammation and immunoregulation in glioblastoma and brain metastases: Recent developments in imaging approaches	25
Neutrophil-mediated mechanisms of damage and in-vitro protective effect of colchicine in non-vascular Behçet's syndrome	25

Analysis of T and NK cell subsets in the Sicilian population from young to supercentenarian: The role of age and gender	25
Outcomes following SARS-CoV-2 infection in patients with primary and secondary immunodeficiency in the UK	25
Endothelial-to-mesenchymal transition in systemic sclerosis	25
Spliced HLA-bound peptides: a Black Swan event in immunology	22
Magnetic resonance imaging in neuromyelitis optica spectrum disorder	21
Whole blood interleukin-2 release test to detect and characterize rare circulating gluten-specific T cell responses in coeliac disease	21
The regulatory role of eosinophils in viral, bacterial, and fungal infections	21
Treg specialization and functions beyond immune suppression	21
Regulatory T-cell therapy approaches	20
Cytokine production by human B cells: role in health and autoimmune disease	20
Exhausted T cells in systemic lupus erythematosus patients in long-standing remission	20
Exosomal PD-L1 predicts response with immunotherapy in NSCLC patients	20
A close-up on the expanding landscape of CD21–/low B cells in humans	19
Metabolites as drivers and targets in rheumatoid arthritis	19
Bronchiectasis is associated with delayed diagnosis and adverse outcomes in the New Zealand Common Variable Immunodeficiency Disorders cohort study	19
Variety of endosomal TLRs and Interferons (IFN-α, IFN-β, IFN-γ) expression profiles in patients with SLE, SSc and MCTD	18
Immunotherapeutic targeting of activating natural killer cell receptors and their ligands in cancer	18
Patho-immunological mechanisms of vitiligo: the role of the innate and adaptive immunities and environmental stress factors	17
Autophagy modulation in multiple sclerosis and experimental autoimmune encephalomyelitis	17
The clinical, molecular, and therapeutic features of patients with IL10/IL10R deficiency: a systematic review	17
Adoptive transfer of immunomodulatory M2 macrophages suppresses experimental autoimmune encephalomyelitis in C57BL/6 mice via blockading NF-κB pathway	16
Isotype selection for antibody-based cancer therapy	15
Adaptive immune system in pulmonary sarcoidosis—Comparison of peripheral and alveolar biomarkers	14
Immunological basis of early clearance ofMycobacterium tuberculosisinfection: the role of natural killer cells	14
Lymphadenopathy at the crossroad between immunodeficiency and autoinflammation: An intriguing challenge	14
Bone marrow-derived mesenchymal stem cells inhibit CD8+ T cell immune responses via PD-1/PD-L1 pathway in multiple myeloma	14
B cell contribution to immunometabolic dysfunction and impaired immune responses in obesity	14
Antibodies as biomarkers for cancer risk: a systematic review	14
Immune checkpoint expression on peripheral cytotoxic lymphocytes in cervical cancer patients: moving beyond the PD-1/PD-L1 axis	14
Mechanisms of induction of regulatory B cells in the tumour microenvironment and their contribution to immunosuppression and pro-tumour responses	14
Inborn errors of immunity with loss- and gain-of-function germline mutations in STAT1	13
The ups and downs of STAT3 function: too much, too little and human immune dysregulation	13
Endothelial cells response to neutrophil-derived extracellular vesicles miRNAs in anti-PR3 positive vasculitis	13
The potential for treg-enhancing therapies in nervous system pathologies	13
FAM96A knock-out promotes alternative macrophage polarization and protects mice against sepsis	13
Impaired function of PD-1+ follicular regulatory T cells in systemic lupus erythematosus	13
Kinetic studies of galectin-10 release from eosinophils exposed to proliferating T cells	13
Th22 response induced byMycobacterium tuberculosisstrains is closely related to severity of pulmonary lesions and bacillary load in patients with multi-drug-resistant tuberculosis	13
Increased TNF-α production in response to IL-6 in patients with systemic inflammation without infection	12
E3 ubiquitin ligase Casitas B lineage lymphoma-b and its potential therapeutic implications for immunotherapy	12
Potential role of BAY11-7082, a NF-κB blocker inhibiting experimental autoimmune encephalomyelitis in C57BL/6J mice via declining NLRP3 inflammasomes	12
E3 ubiquitin ligases STUB1/CHIP contributes to the Th17/Treg imbalance via the ubiquitination of aryl hydrocarbon receptor in rheumatoid arthritis	12
Impairment of antigen-presenting function of peripheral γδ T cells in patients with sepsis	12
Neutrophils in autoimmunity: when the hero becomes the villain	12
Single-cell transcriptome analysis reveals endometrial immune microenvironment in minimal/mild endometriosis	12
Baicalein inhibits macrophage lipid accumulation and inflammatory response by activating the PPARγ/LXRα pathway	12
SARS-CoV-2 vaccine responses following CD20-depletion treatment in patients with haematological and rheumatological disease: a West Midlands Research Consortium study	12
Follicular helper and follicular regulatory T cell subset imbalance is associated with higher activated B cells and abnormal autoantibody production in primary anti-phospholipid syndrome patients	12
Immune checkpoint inhibitors and cellular treatment for lymphoma immunotherapy	12
LncRNA MIR155HG functions as a ceRNA of miR-223-3p to promote cell pyroptosis in human degenerative NP cells	11

Clinical and laboratory findings in patients with leukocyte adhesion deficiency type I: A multicenter study in Turkey	11
Low-density neutrophils in chronic graft versus host disease (cGVHD) are primarily immature CD10– and enhance T cell activation	11
Intravenous immunoglobulin induces IgG internalization by tolerogenic myeloid dendritic cells that secrete IL-10 and expand Fc-specific regulatory T cells	11
Altered inflammasome activation in neonatal encephalopathy persists in childhood	11
Maternal body mass index is associated with an altered immunological profile at 28 weeks of gestation	11
IRF5 regulates airway macrophage metabolic responses	11
CD27 on human memory B cells–more than just a surface marker	11
The role of lipid metabolism in shaping the expansion and the function of regulatory T cells	11
Behçet disease, new insights in disease associations and manifestations: a next-generation sequencing study	10
Treatment with lysophosphatidic acid prevents microglial activation and depression-like behaviours in a murine model of neuropsychiatric systemic lupus erythematosus	10
Seroconversion following COVID-19 vaccination: can we optimize protective response in CD20-treated individuals?	10
Reference range of naïve T and T memory lymphocyte subsets in peripheral blood of healthy adult	10
The autoimmune encephalitis-related cytokine TSLP in the brain primes neuroinflammation by activating the JAK2-NLRP3 axis	10
Dendritic cells metabolism: a strategic path to improve antitumoral DC vaccination	10
Mediterranean fever gene variants modify clinical phenotypes of idiopathic multi-centric Castleman disease	10
Citrullinated inter-alpha-trypsin inhibitor heavy chain 4 in arthritic joints and its potential effect in the neutrophil migration	10
Circulating regulatory T cells in adult-onset Still's disease: Focusing on their plasticity and stability	10
Gingival transcriptomics of follicular T cell footprints in progressing periodontitis	10
Kidney infiltrating NK cells and NK-like T-cells in lupus nephritis: presence, localization, and the effect of immunosuppressive treatment	10
Not too little, not too much: the impact of mutation types in Wiskott-Aldrich syndrome and RAC2 patients	10
CMV infection combined with acute GVHD associated with poor CD8+ T-cell immune reconstitution and poor prognosis post-HLA-matched allo-HSCT	10
RORγt+Foxp3+ regulatory T cells in the regulation of autoimmune arthritis	10
Non-organ-specific autoimmunity in adult 47,XXY Klinefelter patients and higher-grade X-chromosome aneuploidies	9
Body mass index and adipokines/cytokines dysregulation in systemic sclerosis	9
CD155 expression impairs anti-PD1 therapy response in non-small cell lung cancer	9
Sicilian semi- and supercentenarians: identification of age-related T-cell immunophenotype to define longevity trait	9
Atypical phenotype and response of B cells in patients with seropositive rheumatoid arthritis	9
CD4+LAG-3+ T cells are decreased in active psoriatic arthritis patients and their restorationin vitrois mediated by TNF inhibitors	9
CD21low B cells are predictive markers of new digital ulcers in systemic sclerosis	9
Clinical features and nasal inflammation in asthma and allergic rhinitis	9
Altered distributions in circulating follicular helper and follicular regulatory T cells accountable for imbalanced cytokine production in multiple sclerosis	9
Lymphocyte modulation by tofacitinib in patients with rheumatoid arthritis	9
Evaluation of QuantiFERON SARS-CoV-2 interferon-γ release assay following SARS-CoV-2 infection and vaccination	9
Exosome-transmitted S100A4 induces immunosuppression and non-small cell lung cancer development by activating STAT3	9
Immunodeficiency (CVID and CD4 lymphopenia) is associated with a high risk of malignancy among adults with primary immune deficiency	9
Inflammatory cytokine responses in children with asymptomatic malaria infection living in rural, semi-urban and urban areas in south-eastern Gabon	9
British Society for Immunology and United Kingdom Primary Immunodeficiency Network (UKPIN) consensus guideline for the management of immunoglobulin replacement therapy	8
Chloroquine reduces neutrophil extracellular trap (NET) formation through inhibition of peptidyl arginine deiminase 4 (PAD4)	8
Immunopathology of the optic nerve in multiple sclerosis	8
A single-center pilot study in Malaysia on the clinical utility of whole-exome sequencing for inborn errors of immunity	8
The role of Dock2 on macrophage migration and functions during Citrobacter rodentium infection	8
Expression levels of cellular inhibitor of apoptosis proteins and colitogenic cytokines are inversely correlated with the activation of interferon regulatory factor 4	8
Relapse rate and renal prognosis in ANCA-associated vasculitis according to long-term ANCA patterns	8
Regulatory T-cell dysfunction and its implication for cell therapy	8
Increased circulating PD-1hiCXCR5− peripheral T helper cells are associated with disease activity of ANCA-associated vasculitis	8
The AHNAK induces increased IL-6 production in CD4+ T cells and serves as a potential diagnostic biomarker for recurrent pregnancy loss	8
Macrophages in ovarian cancer and their interactions with monoclonal antibody therapies	8
Human B-cell subset identification and changes in inflammatory diseases	8
Splenectomy modulates the immune response but does not prevent joint inflammation in a mouse model of RA	8
The potential for Treg-enhancing therapies in transplantation	8
A hyperacute immune map of ischaemic stroke patients reveals alterations to circulating innate and adaptive cells	8
Genetics of Immune Dysregulation and Cancer Predisposition: Two Sides of the Same Coin	8
Leukocyte immunoglobulin-like receptor A3 is increased in IBD patients and functions as an anti-inflammatory modulator	8
Microvesicles in active lupus nephritis show Toll-like receptor 9-dependent co-expression of galectin-3 binding protein and double-stranded DNA	7
Comparison of two T-cell assays to evaluate T-cell responses to SARS-CoV-2 following vaccination in naïve and convalescent healthcare workers	7
miR-155-overexpressing monocytes resemble HLAhighISG15+ synovial tissue macrophages from patients with rheumatoid arthritis and induce polyfunctional CD4+ T-cell activation	7
The longitudinal loss of islet autoantibody responses from diagnosis of type 1 diabetes occurs progressively over follow-up and is determined by low autoantibody titres, early-onset, and genetic varia	7
The mechanism on Prevotella melaninogenica promoting the inflammatory progression of oral lichen planus	7
Circulating anti-citrullinated protein antibodies containing secretory component are prognostic for arthritis onset in at-risk patients	7
Antigen-specific immunotherapy to restore antigen-specific tolerance in Type 1 diabetes and Graves’ disease	7
Nuclear factor kappa B inhibitor suppresses experimental autoimmune neuritis in mice via declining macrophages polarization to M1 type	7
Whole-exome sequencing of T-B+ severe combined immunodeficiency in Egyptian infants, JAK3 predominance and novel variants	7
Chronic bacterial pulmonary infections in advanced cystic fibrosis differently affect the level of sputum neutrophil elastase, IL-8 and IL-6	7
Decoding the proregenerative competence of regulatory T cells through complex tissue regeneration in zebrafish	7
The TOX subfamily: all-round players in the immune system	7
Progressive B cell depletion in human MALT1 deficiency	7
Immunometabolic adaptation and immune plasticity in pregnancy and the bi-directional effects of obesity	7
Bacillus Calmette–Guérin Tokyo-172 vaccine provides age-related neuroprotection in actively induced and spontaneous experimental autoimmune encephalomyelitis models	7
Clinical features, diagnosis, and management of pembrolizumab-induced myasthenia gravis	7
Tofacitinib treatment modulates the levels of several inflammation-related plasma proteins in rheumatoid arthritis and baseline levels of soluble biomarkers associate with the treatment response	7