OOIR: Observatory of International Research

Papers

(The TQCC of Clinical and Experimental Immunology is 8. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-05-01 to 2025-05-01.)

Article	Citations
Issue Information	67
Human in vitro-induced IL-17A+ CD8+ T-cells exert pro-inflammatory effects on synovial fibroblasts	63
Correction to: Type 1 interferon auto-antibodies are elevated in patients with decompensated liver cirrhosis	62
The alteration of mucosal bile acid profile is associated with nerve growth factor expression in mast cells and bowel symptoms in diarrhea-predominant irritable bowel syndrome	57
The PPAR-γ agonist pioglitazone exerts proinflammatory effects in bronchial epithelial cells during acute Pseudomonas aeruginosa pneumonia	52
Secretory-IgA binding to intestinal microbiota attenuates inflammatory reactions as the intestinal barrier of preterm infants matures	45
Destined for the intestine: thymic selection of TCRαβ CD8αα intestinal intraepithelial lymphocytes	45
Issue Information	42
Regulatory T cells in inflamed liver are dysfunctional in murine primary biliary cholangitis	41
Outcomes following SARS-CoV-2 infection in patients with primary and secondary immunodeficiency in the UK	39
Correction to: Cisplatin-mediated down-regulation of miR-145 contributes to up-regulation of PD-L1 via the c-Myc transcription factor in cisplatin-resistant ovarian carcinoma cells	39
Gingival transcriptomic patterns of macrophage polarization during initiation, progression, and resolution of periodontitis	37
Identification of ANXA2 on epithelial cells as a new receptor for secretory IgA using immunoprecipitation and mass spectrometry	37
Defining the cross-reactivity between peanut allergens Ara h 2 and Ara h 6 using monoclonal antibodies	35
Extracellular vesicles containing PD-L1 contribute to CD8+ T-cell immune suppression and predict poor outcomes in small cell lung cancer	34
Panobinostat enhances NK cell cytotoxicity in soft tissue sarcoma	33
Cytokine production by human B cells: role in health and autoimmune disease	33
Immunotherapeutic targeting of activating natural killer cell receptors and their ligands in cancer	32
The B-cells paradigm in systemic sclerosis: an update on pathophysiology and B-cell-targeted therapies	31
Diagnostic accuracy of saliva-based testing as a Vibrio cholerae surveillance tool among naturally infected patients	31
Reduced response to SARS-CoV-2 vaccination is associated with impaired immunoglobulin class switch recombination in SLE patients	30
C/EBPε and its acetylation in PMN enhance the tolerance to trauma	29
Amlexanox targeted inhibition of TBK1 regulates immune cell function to exacerbate DSS-induced inflammatory bowel disease	29
IgLON5 autoimmunity tested positive in patients with isolated chronic insomnia disease	28
Molecular neuroimaging of inflammation in HIV	27

IL-38 alleviates airway remodeling in chronic asthma via blocking the profibrotic effect of IL-36γ	27
Exposure of female NZBWF1 mice to imiquimod-induced lupus nephritis at an early age via a unique mechanism that differed from spontaneous onset	26
Heterosubtypic, cross-reactive immunity to human Cytomegalovirus glycoprotein B	26
Phenotypic and functional characteristics of highly differentiated CD57+NKG2C+ NK cells in HIV-1-infected individuals	25
The effect of immunomodulatory therapy with recombinant human interferon alpha-2β on blood cytokine levels in children with recurrent episodes of acute obstructive bronchitis	24
Periapical lesion following Cnm-positiveStreptococcus mutanspulp infection worsens cerebral hemorrhage onset in an SHRSP rat model	24
Differentiating between activation via the lectin or the classical complement pathway in patients with systemic lupus erythematosus	23
Exploring S100A8/A9, neopterin, and MMP3 in familial Mediterranean fever	22
Immune profiling reveals umbilical cord blood mononuclear cells from South India display an IL-8 dominant, CXCL-10 deficient polyfunctional monocyte response to pathogen-associated molecular patterns	22
Investigating immune profile by CyTOF in patients with eosinophilic esophagitis after treatment with orodispersible budesonide	21
Patho-immunological mechanisms of vitiligo: the role of the innate and adaptive immunities and environmental stress factors	21
Exosomal PD-L1 predicts response with immunotherapy in NSCLC patients	20
Clinical and neuroimaging findings in MOGAD–MRI and OCT	19
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Systemic sclerosis and primary biliary cholangitis share an antibody population with identical specificity	18
Inborn errors of immunity-related immunological mechanisms and pharmacological therapy alternatives in periodontitis	18
Impaired function of PD-1+ follicular regulatory T cells in systemic lupus erythematosus	18
Ethnic differences in complement system biomarkers and their association with metabolic health in men of Black African and White European ethnicity	18
NK-cell receptor modulation in viral infections	17
Essential role of interferon-regulatory factor 4 in regulating diabetogenic CD4+ T and innate immune cells in autoimmune diabetes in NOD mice	17
Clinical significance of differential serum-signatures for early prediction of severe dengue among Eastern Indian patients	17
The longitudinal loss of islet autoantibody responses from diagnosis of type 1 diabetes occurs progressively over follow-up and is determined by low autoantibody titres, early-onset, and genetic varia	16
NRF1 knockdown alleviates lipopolysaccharide-induced pulmonary inflammatory injury by upregulating DKK3 and inhibiting the GSK-3β/β-catenin pathway	16
Introducing our new series: Clinical and Experimental Treatment of…	16
The CXCL10-CXCR3 axis plays an important role in Kawasaki disease	16
Regulatory T cells in autoimmune primary adrenal insufficiency	15
Increased levels of pathogenic Th17 cells and diminished function of CD69+ Treg lymphocytes in patients with overweight	15
Surface protein and functional analyses identify CD4+CD39+ TCR αβ+ and activated TCR Vδ1+ cells with distinct pro-inflammatory functions in Crohn’s disease lesions	15
Evaluation of a fit-for-purpose assay to monitor antigen-specific functional CD4+ T-cell subpopulations in rheumatoid arthritis using flow cytometry–based peptide-MHC class-II tetramer staining	15
A single-center pilot study in Malaysia on the clinical utility of whole-exome sequencing for inborn errors of immunity	15
Coexistence of apoptosis, pyroptosis, and necroptosis pathways in celiac disease	14
Elevated expression of TAM receptor tyrosine kinase in synovial fluid and synovial tissue of rheumatoid arthritis	14
Inborn errors of immunity: the Goldilocks effect—susceptibility to disease due to a little too much or a little too little	14
Identifying platelet-derived factors as amplifiers ofB. burgdorferi-induced cytokine production	14
CMTM6: increased circulating level and up-regulated expression in labial salivary glands in patients with primary Sjogren’s syndrome	13
16α-Bromoepiandrosterone as a new candidate for experimental diabetes–tuberculosis co-morbidity treatment	13
Pneumococcal serotype-specific antibodies in children with recurrent oto-sinopulmonary infections	13
The effect of short-chain fatty acids on M2 macrophages polarizationin vitroandin vivo	13
Serum and urine free light chains measurements in patients with systemic sclerosis: novel biomarkers for disease activity	13
A study of changes in hematologic parameters in patients with migraine	13
Hyperosmolar environment and salivary gland epithelial cells increase extra-cellular matrix remodeling and lymphocytic infiltration in Sjögren’s syndrome	13
Yeast β-glucan modulates macrophages and improves antitumor NK-cell responses in cancer	12
The pathogenesis of multiple sclerosis: a series of unfortunate events	12
The role of extracellular vesicle immune checkpoints in cancer	12
Exposure to gestational diabetes mellitus increases subclinical inflammation mediated in part by obesity	12
Interleukin 17 receptor E identifies heterogeneous T helper 17 cells in peritoneal fluid of moderate and severe endometriosis patients	12
A close-up on the expanding landscape of CD21–/low B cells in humans	12
Diagnostic markers and potential therapeutic agents for Sjögren’s syndrome screened through multiple machine learning and molecular docking	11
Cytometric analysis of T cell phenotype using cytokine profiling for improved manufacturing of an EBV-specific T cell therapy	11
Proteomic analysis reveals dysregulation of peripheral blood neutrophils in patients with Multiple Sclerosis	11

Identification of angiogenesis-related genes and molecular subtypes for psoriasis based on random forest algorithm	11
Immune cell composition and inflammatory profile of human peri-implantitis and periodontitis lesions	11
Altered peripheral B lymphocyte homeostasis and functions mediated by IL‐27 via activating the mammalian target of rapamycin signaling pathway in patients with rheumatoid arthritis	11
Analysis of T and NK cell subsets in the Sicilian population from young to supercentenarian: The role of age and gender	11
Increased expression of CXCL10 and CCL3 salivary gland chemokines in primary Sjögren’s syndrome detected and systematically quantified using RNAscope®in situ hybridization	11
Droplet digital PCR for identifying copy number variations in patients with primary immunodeficiency disorders	11
Autophagy modulation in multiple sclerosis and experimental autoimmune encephalomyelitis	11
Time to treat the climate and nature crisis as one indivisible global health emergency	11
Preparation of mesoporous silica nanocarriers targeting glucose-6-phosphate isomerase inhibition and application in the treatment of rheumatoid arthritis	11
Innate stimulation of B cells ex vivo enhances antibody secretion and identifies tumour-reactive antibodies from cancer patients	11
Effects of mesenchymal stem cells on Treg cells in rats with colitis	11
Inhibitor of apoptosis-stimulating p53 protein protects against inflammatory bowel disease in mice models by inhibiting the nuclear factor kappa B signaling	11
	11
Harnessing the power of memory-like NK cells to fight cancer	11
Pirfenidone alleviates interstitial lung disease in mice by inhibiting neutrophil extracellular trap formation and NLRP3 inflammasome activation	11
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Natural killer cells and innate lymphoid cells but not NKT cells are mature in their cytokine production at birth	11
Difference in respiratory syncytial virus-specific Fc-mediated antibody effector functions between children and adults	10
Inborn errors of immunity with loss- and gain-of-function germline mutations in STAT1	10
Increased expression of complement C3c, iC3b, and cells containing CD11b or CD14 in experimentally induced psoriatic lesion	10
Patients diagnosed with COVID-19 and treated with anakinra: a real-world study in the USA	10
Application of whole-exome sequencing to predict inborn errors of immunity in pediatric severe infections and sepsis	10
Persistence of the immune response after two doses of ChAdOx1 nCov-19 (AZD1222): 1 year of follow-up of two randomized controlled trials	10
Induction of memory-like CD8+ T cells and CD4+ T cells from human naive T cells in culture	10
The immune landscape of the inflamed joint defined by spectral flow cytometry	10
HTNV infection induces activation and deficiency of CD8+MAIT cells in HFRS patients	10
Response to Letter to the Editor: Type 2 diabetes is associated with the accumulation of senescent T cells	10
Tocilizumab suppresses NF-kappa B activation via toll-like receptor 9 signaling by reducing cell-free DNA in rheumatoid arthritis	10
Acute hepatitis of unknown aetiology in children: a clinical update on the recent outbreak with mechanistic insights	10
Parallel origins and functions of T cells and ILCs	10
CD4+LAG-3+ T cells are decreased in active psoriatic arthritis patients and their restorationin vitrois mediated by TNF inhibitors	10
Discovery and Phase 1 study of a novel monoclonal antibody against human IL-1β for the treatment of IL-1β-mediated diseases	10
2B4: A potential target in Staphylococcus aureus associated allergic inflammation	9
Altered CD226/TIGIT expressions were associated with NK phenotypes in primary antiphospholipid syndrome and affected by IL-4/JAK pathway	9
Leptin-reactive antibodies are distinctly correlated with body composition parameters and metabolic risk indexes in children and adolescents	9
Nck1 regulates the in vitro development of human regulatory T cells through AKT pathway	9
Neutrophil-mediated mechanisms of damage and in-vitro protective effect of colchicine in non-vascular Behçet's syndrome	9
Follow-up of immune response in patients with common variable immunodeficiency following SARS-CoV-2 vaccination	9
Improved function and balance in T cell modulation by endothelial cells in young people	9
Regulatory T-cell frequency and function in acute myocardial infarction patients and its correlation with ventricular dysfunction	9
The TOX subfamily: all-round players in the immune system	9
COVID-19 infection and vaccination in immunodeficiency	9
What do we know about co-stimulatory and co-inhibitory immune checkpoint signals in ankylosing spondylitis?	9
Anti-glutathione S-transferase omega 1-1 (GSTO1-1) antibodies are increased during acute and chronic inflammation in humans	9
Human FCHO1 deficiency: review of the literature and additional two cases	8
Unveiling WHIM syndrome: Mavorixafor’s emerging role in immune restoration and therapy	8
A novel monoclonal antibody with improved FcγR blocking ability demonstrated non-inferior efficacy compared to IVIG in cynomolgus monkey ITP model at considerably lower dose	8
Genetic correlation between thyroid hormones and Parkinson’s disease	8
Multi-dimensional analysis of B cells reveals the expansion of memory and regulatory B-cell clusters in humans living in rural tropical areas	8
PMA induces the differentiation of monocytes into immunosuppressive MDSCs	8
Leucine-rich repeat kinase 2 promotes the development of experimental severe acute pancreatitis	8
My highlights as Editor-in-Chief of Clinical & Experimental Immunology, 2017–2024	8
Catalase inhibition can modulate the ability of peripheral blood T cells to undergo apoptosis in Crohn’s disease	8
Gene expression analysis revealed downregulation of complement receptor 1 in clonal B cells in cold agglutinin disease	8
SR-A neutralizing antibody: potential drug candidate for ameliorating osteoclastogenesis in rheumatoid arthritis	8
MASP2 inhibition by narsoplimab suppresses endotheliopathies characteristic of transplant-associated thrombotic microangiopathy:in vitroandex vivoevidence	8
Environmental pollutant 3-methyl-4-nitrophenol promotes the expression of oncostatin M to exacerbate airway allergic inflammation	8
Establishing the prevalence of common tissue-specific autoantibodies following severe acute respiratory syndrome coronavirus 2 infection	8
Autoimmune/inflammatory syndrome induced by adjuvants (ASIA): past, present, and future implications	8
Clinical features and nasal inflammation in asthma and allergic rhinitis	8
Dynamic mRNA expression of donor-derived activating KIR genes and their significant effects on clinical outcome after haematopoietic stem cell transplantation	8
Investigating Concomitant RAG-2 and LRBA Mutations in SCID and Autoimmunity	8
The prevalence of anti-neurofascin-155 antibodies in patients with neuromyelitis optica spectrum disorders	8