Clinica Chimica Acta

Article	Citations
External quality assessment for molecular detection of Ureaplasma urealyticum in China	156
Epigenetics of Diabetes: A bioinformatic approach	106
Evaluation of thrombin generation assay in factor XI deficiency	101
Monocyte distribution width and the fighting action to neutralize sepsis (FANS) score for sepsis prediction in emergency department	78
MicroRNA biosensors for detection of glioblastoma	74
A large cohort of Hb H disease in northeast Thailand: A molecular revisited, diverse genetic interactions and identification of a novel mutation	73
A comprehensive molecular approach in fish allergy: Usefulness in daily clinical practice	69
Omentin-1: Protective impact on ischemic stroke via ameliorating atherosclerosis	64
Associations of glycated albumin and fructosamine with glycaemic status in urban black South Africans	62
Reference intervals for plasma vitamin B12 and plasma/serum methylmalonic acid in Danish children, adults and elderly	60
Comparative study of droplet-digital PCR and absolute Q digital PCR for ctDNA detection in early-stage breast cancer patients	57
Presence of anti-gp210 or anti-sp100 antibodies in AMA-positive patients may help support a diagnosis of primary biliary cholangitis	56
Value of urine/serum Neutrophil gelatinase-associated lipocalin ratio in distinguishing acute kidney injury from chronic kidney disease	55
SLC37A4-CDG: New biochemical insights for an emerging congenital disorder of glycosylation with major coagulopathy	52
Emerging role of serum dickkopf-1 in prognosis of aneurysmal subarachnoid hemorrhage	47
Next-generation reference interval for total IgE in the United States: A retrospective real-world analysis	46
Crescent calculator: A webtool enabling objective decision-making for assessment of IgA nephropathy immune activity throughout the disease course	46
Functions of nuclear receptors SUMOylation	43
Exploration and time-serial validation of logistic regression models composed of multiple laboratory tests for early detection of HCV-associated hepatocellular carcinoma	42
Irisin in atherosclerosis	42
Targeted next-generation sequencing reveals novel and known variants of thrombophilia associated genes in Saudi patients with venous thromboembolism	40
Effects of blood-processing protocols on cell-free DNA fragmentomics in plasma: Comparisons of one- and two-step centrifugations	39
Quantification of choline in serum and plasma using a clinical nuclear magnetic resonance analyzer	39
Polymyositis and dermatomyositis biomarkers	38
Biological variation of cardiovascular biochemical markers in patients with Type 2 Diabetes Mellitus	37

Extracellular vesicle-transferred long noncoding RNAs in bladder cancer	36
Circulating microparticles as indicators of cardiometabolic risk in PCOS	35
Application of chemoresistive gas sensors and chemometric analysis to differentiate the fingerprints of global volatile organic compounds from diseases. Preliminary results of COPD, lung cancer and br	35
Reference interval establishment and correlation research of urine thromboxane metabolites: Unveiling new possibilities in platelet activation	34
Circulating HPV DNA in HPV-associated cancers	34
Hook-effect in MAGLUMI immunoassay for serum anti-GAD antibodies in neurological disorders: When “wrong” matrix is the right choice	34
Detection of mutation profiles and tumor mutation burden of cerebrospinal fluid circulating DNA by a cancer genomic panel sequencing in glioma patients	34
Editorial Board	34
Genetic architecture of preeclampsia	34
Comparative study of plasma clearance of iohexol at different injection doses	34
Diagnostic potential of vitreoretinal lymphoma by detection of gene mutations with NGS in 25 Chinese patients	33
Delta check limits for thyroid function tests adjusted for clinical settings	32
“Tranq-dope”: The first fatal intoxication due to xylazine-adulterated heroin in Italy	31
An atypical finding on serum immunofixation in free light chain multiple myeloma: A case report	29
First case of 5-oxoprolinuria with two homozygous mutations in GSS and OPLAH genes: A case with neonatal presentation and rapid fatal outcome	29
Changes in plasma level of endocrine hormones in lepromatous leprosy patients	29
MMP-26 potential utility as a marker for differentiating serous ovarian cancer from serous cystadenomas	28
Pre-analytical issues in haemostasis	28
Does long term PPI use cause vitamin B12 deficiency ?	28
Quantification of serum gp210 and sp100 antibodies in diagnosis of primary biliary cholangitis	28
“Revolutionizing emergency care: A comparative analysis of comprehensive point-of-care test panels vs conventional laboratory processes in the critical care& emergency medicine”	27
Carbapenem-resistant Enterobacteria at the hospital of Monastir	27
Adoption and barriers to participation in a comparison program of core laboratory quality indicators among hospitals in Toronto, Canada	26
In-vitro and in-vivo studies of M. oliefera derived compounds as a promising therapeutic target in breast cancer progression and metastasis	26
Cell-free DNA bearing p53 mutation (R248) as non-invasive biomarker in patients with head and neck squamous cell carcinoma	26
Using big data analytics to measure the multi-year consistency of sigma metrics for vitros cardiac assays	26
Assessment of serum osteopontin, osteoprotegerin and bone-specific alp as markers of bone turnover in patients with disorders of thyroid function in Ile-Ife, Nigeria	25
Impact of laboratory accreditation on the performance of quality indicators in an international indicator benchmarking program	25
Implementation of first coagulation total laboratory automation system in Taiwan – An experience from a 3000-beds medical center	25
Association of single nucleotide polymorphisms in eNOS gene with development of diabetic nephropathy: A case control study	24
Overweight and insulin resistance in Algerian adolescent	24
Calculated LDL cholesterol (freidwald, martin johns and Sampson) comparison of retrospective data with direct LDL cholesterol and hypertriglyceridaemia	24
Total lab automation validation/verification: First step of process excellence journey in smart core lab	24
Evaluation of the current status of the vitamin D assay standardization in China	23
Novel prediction model of early screening lung adenocarcinoma with pulmonary fibrosis based on haematological index	23
Unveiling liquid markers: The diagnostic revolution in early detection of pancreatic cancer through liquid biopsy	23
Availability of ionized magnesium active form depends on kidney function and albumin levels	23
Performance of laboratory services and systems in laboratory of a hospital in Nepal	23
The connection of Vitamin D concentration with hematological parameters in patients with COVID-19	22
Platelet volume indices and their association with atherogenic index of plasma in type 2 diabetes mellitus patients	22
Advanced oxidation protein products and catalase activity in patients with psoriasis	22
Diagnostic pitfalls in ANCA testing by ANA patterns and titers	22
Antibiotic resistance profile of enterobacteriaceae isolated from infected hemodialysis catheters	22
Transferability and degree of harmonization of an LC-MS based reference measurement procedure for apolipoproteins in a network of calibration laboratories	22
Changes in nonalcoholic fatty liver disease and M2BPHI due to lifestyle intervention in primary healthcare	21
Can lipid mediators be useful biomarkers in schizophrenia?	21
Plasma 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D levels in breast cancer risk in Mali: A case–control study	21
Review on the most important methylated genes in circulatory tumor DNA of brain tumor patients: Novel horizon towards early diagnosis and therapeutic follow up	21
Evaluation of interleukin-4, micro-albumin, and creatinine in students exposed to short-term formal in Nnewi	21
Performance of laboratory services and systems in laboratory of a hospital in Nepal	21

Differentiation of HbD and HbG-philadelphia by HbA concentration during neonatal screening	20
Evaluation OF FGF-23 as a marker of mineral bone disease among newly diagnosed chronic kidney disease patients in a Nigerian hospital	20
Failure to diagnose factor X deficiency in patient treated with anticoagulant therapy: A fatal case	20
Exploring artificial intelligence techniques for morphological analysis of digital images of peripheral blood cells: MC-80 versus HemaVision	20
Treating red blood cells with dithiothreitol can help eliminate daratumumab interference in blood compatibility tests (pretransfusion testing)	20
Faecal calprotectin as a potential biochemical marker of ulcerative colitis activity stratification	20
Accurate correction model of blood potassium concentration in hemolytic specimens	19
The biochemical and cytological examination of the cerebrospinal fluid (CSF) and the number of erythrocytes	19
Beyond direct methods: Establishing vitamin d reference intervals using real-world data	19
Possibility of using erythrocyte indexes to predict clinical outcome in patients with burn injury	19
Raman spectroscopic analysis of urine combined with machine learning identifies life-threatening inborn errors of metabolism	19
Association between serum lipid profile and clinicopathological features in breast cancer patients	19
The influence of thyroid autoantibodies on depression severity	19
Serum adenosine deaminase as breast and colorectal cancer progression biomarker	19
Evaluation of the management of infectious risk at the laboratories of the Yaounde University Teaching Hospital	19
Detection of hotspot PIK3CA mutations in primary tumors and plasma-cfDNA of breast cancer patients using a novel highly sensitive CE-IVD KIT	19
Earthquakes, wars and emerging infectious disease	18
Cardiorenal syndrome and diabetes mellitus in indonesian population	18
Anti-diabetic and anti-inflammatory properties of some selected plant leaves: A transcriptomic approach	18
Evaluation of phosphocalcic metabolism and vitamin d status in renal transplant patients at military hospital of Oran, Algeria	17
Verification of equimolar peptide release in a mass spectrometry-based reference measurement procedure for quantification of Apolipoprotein(A)	17
Investigating the long-term effects of lung-specific autoantibodies post-COVID-19 following thoracic surgery	17
Myo-inositol: A novel biomarker for kidney disease	17
Mid-Regional proadrenomedullin (MR-PROADM) may be a new marker of severity status of patient with systemic inflammatory response-pilot project	17
Hemolysis index measured on Cobas Pro is a good surrogate to plasmatic hemoglobin measurement in clinical pratice	17
An estimation of fructosamine threshold values for the diagnosis of diabetes in a Tunisian population	17
Viscoelastic blood tests use in adult cardiac surgery	17
Heavy-light chain pairs as an alternative method to monitor isatuximab-based treatment responses in multiple myeloma patients	17
Escherichia coli nissle (E.COLI NISSLE) modulated in colon cancer therapy	16
Effects of vitamin D supplementation in neonates and infant	16
Stability of arterial and venous gas samples stored for 20, 40 and 60 minutes after collection	16
The essential role of volunteer biologists in Lebanon’s COVID-19 pandemic management efforts	16
The relationship between disorders of the plasma and platelet components of hemostasis with the severity and timing of coronavirus infection in patients with chronic coronary syndromes	16
COVID-19 infection: a review of hematological and morphological features	16
The management of heart failure patients in a value-based healthcare system: The role of cardiac biomarkers	16
Follow-up of the TG and ANTI-TG in patient with differentiated thyroid cancer by two different analytical methods	16
Strategy to improve the turn around time (TAT) for stat samples in clinical laboratories	16
Results of 2023 national external quality assessment of hemostasis testing in medical laboratories of the Republic of Belarus	16
Comparison of demographical features and chemical composition in patients with renal stones in a tertiary care center	16
The role of unsaturated iron binding capacity (UIBC) in the diagnosis of anemia	15
Large-scale analysis reveals splicing biomarkers for tuberculosis progression and prognosis	15
Fcm in characterizing acute leukemic disorders	15
Imiquimod-loaded chitosan-decorated di-block and tri-block polymeric nanoparticles gel for the management of human cervical intraepithelial neoplasia	15
Management of discrepancies between immunocap specific IgE and the two multiplex test platforms immunocap ISAC and MADx ALEX 2 in a pediatric patient with anaphylaxis	15
Extensive molecular heterogeneity and transcriptomic signatures of circulating tumour cells are potential predictors of oral squamous cell carcinoma	15
Validating urinary orotic acid through high-pressure liquid chromatography (HPLC): Insights from a specialized biochemical genetics laboratory in Pakistan	15
Serum concentration of asymmetrical dimethylarginine and protein carbonyl in patients with cardiovascular diseases	15
Plasma levels of matrix metalloproteinases in patients with breast cancer as a potential marker of cardiotoxicity associated with doxorubicin therapy	15
Laboratory indicators of inflammation in the development of cytokine storm in patients with COVID-19	14
Clinical significance of medical leadership and laboratory management: Challenges and perspectives	14
Unmanned high speed aerial vehicles in medical logistics: A comparative analysis of blood sample transportation with weather variability	14
Real-world data shows the effectiveness of a tetravalent vaccine against human papilloma virus types 16 and 18 in Chilean women	14
Electrophoretic profiles of patients with different types of hemoglobinopathies in south Tunisia	14
Exploring the relationship between Oxysperm and Sperm DNA Fragmentation Index (DFI) in the context of fertility potential	14
Stiff person syndrome (SPR): A case report	14
Data science, digital health, big data and smart technologies to support biotechnology – Current perspectives and future challenges	14
Profile of soluble MER (sMER) and ADAM17 in relation to waist circumference range: Analyzing efferocytosis signaling in men with central obesity	14
Rotational thromboelastometry (CLORPRO) profiling of COVID-19 patients	14
The importance of determining hepcidines and soluble transferrin receptor (STFR) in haemodialysis patients	14
Clinical validation in multiple sclerosis of the lumipulse immunoassay for plasma neurofilament light chain	13
Evaluation of beta glucan test using kinetic turbidimetric method on toxinometer MT-6500 for detection of invasive fungal infections in hospitalized patients	13
The increased sensitivity of the Xpert® Xpress assay in detecting SARS-COV-2, compared to the COBAS® assay, can be attributed to the nucleocapsid gene target	13
Indeterminate results in quantiferon-TB gold plus testing: Possible explanation and predictive parameters	13
Frequency of occurrence of zoonotic tick-borne pathogens in ticks – Latvian 2023 year experience	13
Molecular characterization of vibrio parahaemolyticus isolated from coastal environment in Eastern Province of Saudi Arabia	13
Evaluation of pre-analytical quality indicators by six sigma principle: Experience at a tertiary care hospital	13
Biological investigation of oxalocalcic lithiasis: Contribution of morphoconstitutional analysis and metabolic assessment	13
Evaluation of the diagnostic efficacy of hepatitis C virus infection in our healthcare area	13
Circulating miRNAs associated with physical performance in elderly subjects	13
Quantitative stool culture in hospitalized neonates: Microbiological analysis, antibiotic resistance patterns, and clinical management implications	13
Interference of hemolysis in urgent clinical biochemistry examinations analyzed on DxC 700 AU and access 2	13
A study of c-reactive protein in breast cancer: Risk factor and prognostic	13
Determination of direct oral anticoagulant in the emergency laboratory: The experience in pandemic and post-pandemic period	13
Laboratory-based study of newborn with intrauterine growth restriction	13
Diabetes related foot infections: Bacterial epidemiology and antibiotic susceptibility profiling	13
Escherichia coli in urine: Sensitivity to first-line molecules	13
Blood donation and hepatitis seroprevalence transfusion medicine: A solution or a risk in a Palestinian perspective	12
Still’s syndrome. A case study	12
Isolation, cloning, and sequencing the codiaeum variegatum GAPC gene	12
Principle of flow cytometry and issues in diagnosis	12

Using a diagnostic panel to determine predisposition to the development of disorders of the thyroid system	12
A variant reclassification of SLC12A3 of Gitelman syndrome	12
Association of single nucleotide polymorphism of KCNJ11 (rs 5219) with type 2 diabetes mellitus in north Indian population	12
Six sigma improves the performance of quality control, financial and operation efficiency in a nationwide laboratory network in Mexico	12
Interference in the determination of glycosylated hemoglobin caused by a hemoglobonipathy: A case report	12
Le Mans Protocol – Evidence-based approach to proof your choice of production concept	12
Enhancing the sensitivity of rapid antigen detection test (RADT) of different SARS-COV-2 variants and lineages using fluorescence-labeled antibodies and a fluorescent meter	12
The technology for clinical laboratories in 21st century: Challenges and opportunitie	11
Machine learning-based prediction of intensive care during hospitalization for COVID-19 using laboratory test results at admission	11
Biomarker panels: Analytical and clinical validation against clinically relevant reference standards	11
Intake of selected fat-soluble vitamins and trace elements on selected parameters of skin condition	11
Uric acid lithiasis in southern Tunisia	11
Testosterone II (TSTII) and dimension VISTA® LOCI total testosterone (TTST) immunoassays meet the CDC host certification requirements for more than four years	11
Creating hemolysates using whole blood, are EDTA tubes the right choice?	11
Assessment of vitamin D intake and supplementation in non-dialysis chronic kidney disease patients	11
Next step in predictive medicine: New serum biomarkers to predict acute stroke mortality	11
Incidental diagnosis of aneuploidy of the sex chromosomes in a neuropaediatric patient	11
About a case “a precocious puberty in A 10-month-old infant”	11
Assessment of MSTN and CYP2D6 polymorphisms and physical performance in a population of athletes from Western Mexico	11
Atherogenic indices among women with benign and malignant breast lesions in Ile-Ife, Nigeria	11
Prevalence of serum CEA and CA 19-9 elevation in patients with colorectal cancers at The Nairobi Hospital, Kenya	11
Identification of immunoreactive COVID-19 epitopes based on M13 phage display library	11
Unraveling mechanisms regulating erythroid iron metabolism	11
Effect of cucumber supplementation on blood pressure, plasma lipid profile and some apolipoproteins in older adults in Nnewi, Nigeria	11
The reality of antimicrobial resistance (AMR) in Palestine and its impact on health and economy: A cross-sectional study in West Bank, Palestine	11
Acarbose a promising inhibitor of 17®-hydroxysteroid dehydrogenase type 1 as a potential candidate for anticancer therapy	11
Sickle cell crisis vs thrombotic microangiopathy secondary to neoplastic process: The clinical laboratory in differential diagnosis	11
Genotypic characterization of autosomal dominant polycystic kidney disease (ADPKD) in Indian population: A pilot study	11
Apolipoprotein B and its correlation with dyslipidemia in Type 2 Diabetes Mellitus	11
Effect of Candida auris secretions on monocyte-derived macrophages	11
N-Terminal pro-b-type natriuretic peptide, iron status and red cell distribution width in suspected heart failure patients	11
Antibiotic susceptibility of bacteria isolated in pediatric settings during bacteremia	11
Why do scientists call for action against vitamin D deficiency and what is behind the scene?	11
HDL functionality assessments and its relevance to the cardiovascular endpoints; Mashad cohort study over 10 years	11
Detection of mycobacterium tuberculosis and rifampicin resistance with Xpert® MTB/RIF analysis in a tertiary hospital	11
Path to lab accreditation and improvements	11
Green laboratory medicine in Africa: What is the contribution to environmental toxicity and how prepared is the continent for sustainable laboratory medicine?	10
Risk assessment for patient by centrifugation of samples on the DxA 5000 fit Beckman Coulter automated system	10
Serum anti-oxLDL antibodies in patients with angiographically confirmed coronary artery disease	10
Effect of bilirubin assays on treatment decision in neonatal jaundice: Past and present using Dutch external quality assessment results	10
The pentraxin family in autoimmune disease	10
FIB-4 index: The importance of including pyridoxal-5-phosphate in alt and AST methods	10
Effects of obesity on liver function in children	10
Complete blood count parameters in CKD patients compared to healthy subjects	10
Analysis of thicknesses of blood collection needle by scanning electron microscopy reveals wide heterogeneity	10
Profiling of circulating-MicroRNAs’ signatures in pre-diabetic versus diabetic patients	10
Superfluous amylase and lipase testing	10
A diagnostic dilemma of TSHoma in a clinically euthyroid patient	10
Exploring optimization algorithms for establishing patient-based real-time quality control models	10
Non-coding RNAs as biomarkers of myocardial infarction	10
Editorial Board	10
Prediction of atherosclerosis in severe COVID-19 patients with CD16 and CD18 markers and inflammatory factors	10
Seroprevalence and risk factors of toxoplasmosis among pregnant women in the M’saken region (Tunisia)	10
The clinical value of artificial intelligence in laboratory medicine	10
Laboratory evaluation of RBC transfusion in patients with coronary artery disease	10
Plasma oxidative lipidomics reveals signatures for sepsis-associated acute kidney injury	10
Altered bile metabolome and its diagnostic potential for biliopancreatic malignancies	10
A haemochromatosis-causing HFE mutation is associated with SARS-CoV-2 susceptibility in the Czech population	10
Role of apolipoproteins in the pathogenesis of obesity	9
A rapid multiplex assay of human malaria parasites by digital PCR	9
Resistin and omentin in breast cancer: A systematic review and meta-analysis	9
Additive value of bioclinical risk scores to high sensitivity troponins-only strategy in acute coronary syndrome	9
Identification of the first Alu-mediated gross deletion involving the BCKDHA gene in a compound heterozygous patient with maple syrup urine disease	9
Comparison of digital PCR systems for the analysis of liquid biopsy samples of patients affected by lung and colorectal cancer	9
The early effects of sleeve gastrectomy on postprandial chylomicron triglycerides during the progression of type 2 diabetes	9
Association of serum anti-carbamylated protein antibodies with disease activity and bone loss in rheumatoid arthritis	9
UHPLC-MS/MS-based untargeted lipidomics analysis of septic patients	9
Evaluating the effect of gestational diabetes mellitus on macrosomia based on the characteristics of oral glucose tolerance test	9
Functional characterization of novel variants found in patients with suspected Fabry disease	9
Phosphatidylethanol in patients with liver diseases of different etiologies: Analysis of six homologues and comparison with other alcohol markers	9
Advances in the identification of calcium carbonate urinary crystals	9
Serum metabolomics study of anxiety disorder patients based on LC-MS	9
Exploring the effect of APOE ε4 on biomarkers of neurodegeneration in Alzheimer’s disease	9
Serum Gas6 contributes to clinical outcome after aneurysmal subarachnoid hemorrhage: A prospective cohort study	9
Measuring steroids from dried blood spots using tandem mass spectrometry to diagnose congenital adrenal hyperplasia	9
High CDT without clinical context: Beware of the variant	9
M155 Urinary VMA, HVA and 5-HIAA measurement on HPLC with electrochemical detection – A 3-way method comparison study using commercially available reagents	9
Biomarkers of endometriosis	9
The clinical value of rapidly detecting urinary exosomal lncRNA RMRP in bladder cancer with an RT-RAA-CRISPR/Cas12a method	9
Circulating calprotectin as biomarker in neutrophil-related inflammation: Pre-analytical recommendations and reference values according to sample type	9
Hypomethylation of RPTOR in peripheral blood is associated with very early-stage lung cancer	9
P-tau217 in Alzheimer’s disease	9
Kappa free light chains: Diagnostic performance in multiple sclerosis and utility in a clinical laboratory	9
Seeking consistency for the role of urinary macromolecules and glycosaminoglycans in calcium oxalate crystallization processes pertaining to the risk of renal stone formation using a multi-faceted bas	9
Clot waveform analysis for perioperative hemostatic monitoring in a hemophilia A patient on emicizumab undergoing liver transplantation	9
Biological variation of thyroid function biomarkers over 24 hours	9
Monitoring mutant KRAS in plasma cell-free DNA can predict disease progression in a patient with multiple myeloma: A case report	8
Analysis of the diagnostic and prognostic value of serum PAD2 in patients with sepsis in the intensive care unit	8
M208 Pakistan inherited metabolic disorders network (PAK-IMD-NET): Breaking silos and bringing synergies	8
Cerebrospinal fluid protein biomarkers in Parkinson's disease	8
The role of serum free light chain as biomarker of Myasthenia Gravis	8
Atopic respiratory diseases and IgE sensitization are associated with leukocyte subset concentrations in 14,440 blood donors	8
Detection of pathogens from venous or arterial blood of patients with left-sided infective endocarditis by metagenomic next-generation sequencing: A prospective study	8
High-throughput omics technologies in inflammatory bowel disease	8
M212 Molecular &; biochemical investigations of inborn errors of metabolism & altered redox homeostasis – An underrecognised cause with emerging importance	8