Clinica Chimica Acta

Article	Citations
Evaluating the clinical effectiveness of cardiovascular precision diagnostics	406
Performance evaluation and validation of high-performance liquid chromatography method for the quantification vitamins A and E	140
How did the COVID-19 pandemic impact drug trends?	96
Assessment of an analysing system for the determination of NA+, K+, CL- and CA2+	74
Determine the pharmacokinetics (half-life, volume of distribution and clearance) of AMB-FUBINACA in blood samples of rats using GC-MS/MS	70
Effects of obesity on liver function in children	65
The increased sensitivity of the Xpert® Xpress assay in detecting SARS-COV-2, compared to the COBAS® assay, can be attributed to the nucleocapsid gene target	56
Interference of hemolysis in urgent clinical biochemistry examinations analyzed on DxC 700 AU and access 2	51
Pre-analytical issues in haemostasis	49
Performance evaluation of the architect hepatitis c core antigen assay vs roche HCV DUO	48
Laboratory-based study of newborn with intrauterine growth restriction	47
Exploring artificial intelligence techniques for morphological analysis of digital images of peripheral blood cells: MC-80 versus HemaVision	46
New insights in the newborn screening for methylmalonic aciduria in the Balearic Islands: Surprisingly high prevalence of CD320 gene mutation (transcobalamin receptor)	44
Hypocalcemia and hypomagnesemia among patients with depression attending KFMMC-Dhahran-KSA	43
Indeterminate results in quantiferon-TB gold plus testing: Possible explanation and predictive parameters	43
Association of miRNA-126 cycle threshold values with the blood glucose concentration	42
The effect of calcium chloride on the release of platelet-derived growth factor-BB in the platelet-rich plasma products	40
Treating red blood cells with dithiothreitol can help eliminate daratumumab interference in blood compatibility tests (pretransfusion testing)	40
Improving of test utilization through modification of the electronic ordering system for blood zinc level	39
Evaluation of beta glucan test using kinetic turbidimetric method on toxinometer MT-6500 for detection of invasive fungal infections in hospitalized patients	38
Unveiling liquid markers: The diagnostic revolution in early detection of pancreatic cancer through liquid biopsy	37
Evaluation of pre-analytical quality indicators by six sigma principle: Experience at a tertiary care hospital	37
Association of single nucleotide polymorphisms in eNOS gene with development of diabetic nephropathy: A case control study	36
Immunoglobulin fragmentation challenges the interpretation of capillary protein electrophoresis results	36
Association of ECM remodelling marker gene polymorphisms and their serum levels in acute and recurrent myocardial infarction	36

Evaluation OF FGF-23 as a marker of mineral bone disease among newly diagnosed chronic kidney disease patients in a Nigerian hospital	36
Exploring the potency of Lamiaceae essential oils: Chemical composition and antibacterial efficacy against multidrug-resistant bacteri	36
Evaluation of metabolic and endocrine profiles in the elderly	36
Estimation of glomerular filtration rate with cystatin C in the evaluation of cardiovascular risk	35
A variant reclassification of SLC12A3 of Gitelman syndrome	35
“Revolutionizing emergency care: A comparative analysis of comprehensive point-of-care test panels vs conventional laboratory processes in the critical care& emergency medicine”	35
Why do scientists call for action against vitamin D deficiency and what is behind the scene?	34
Stability of arterial and venous gas samples stored for 20, 40 and 60 minutes after collection	34
Uric acid lithiasis in southern Tunisia	33
Not one-size-fits-all: The types and varieties of dtc tests and their potential harms	32
A system troubleshooting for HIV-1 drug resistance genotyping amplification rate failure at Ethiopian public health institute HIV laboratory	31
The reality of antimicrobial resistance (AMR) in Palestine and its impact on health and economy: A cross-sectional study in West Bank, Palestine	31
Study of the association between vitamin D and anti-mullerian hormone (AMH)	31
Testosterone II (TSTII) and dimension VISTA® LOCI total testosterone (TTST) immunoassays meet the CDC host certification requirements for more than four years	30
Principle of flow cytometry and issues in diagnosis	30
Cardiorenal syndrome and diabetes mellitus in indonesian population	30
Strategy to improve the turn around time (TAT) for stat samples in clinical laboratories	30
Raman spectroscopic analysis of urine combined with machine learning identifies life-threatening inborn errors of metabolism	29
Thyroid profile abnormalities among patients tested at the Nairobi Hospital Laboratory, Kenya	29
Next step in predictive medicine: New serum biomarkers to predict acute stroke mortality	29
Changes in nonalcoholic fatty liver disease and M2BPHI due to lifestyle intervention in primary healthcare	27
Interference in the detection of HBA1C: Detection of abnormal HB presence	27
Antibiotic resistance profile of enterobacteriaceae isolated from infected hemodialysis catheters	27
Editorial Board	27
Editorial Board	27
Detection of mycobacterium tuberculosis and rifampicin resistance with Xpert® MTB/RIF analysis in a tertiary hospital	27
Hematological malignancies: Analysis of complete blood count (CBC) and myelogram results in the Hematology Laboratory of Hedi Chaker Hospital Sfax (South Tunisia)	27
Development of exploratory algorithms to aid in risk of malignancy prediction of indeterminate pulmonary nodules	26
Comparison of various E-GFR equations in estimating glomerular filtration rate in Indians	26
Editorial Board	26
Functional characterization of novel variants found in patients with suspected Fabry disease	26
Identification of cell cycle-related hub genes HMMR AND CDC25C for prognosis of head and neck squamous cell carcinoma through co-expression network analysis	26
Evaluation of a rapid immunochromatographic diagnostic test for heparin-induced thrombocytopenia: validation of delayed test and whole blood test	25
Urinary iodine testing practices in China: Results of the 5-year external quality assessment program	25
Analysis of the diagnostic and prognostic value of serum PAD2 in patients with sepsis in the intensive care unit	25
MicroRNA regulators of vascular pathophysiology in chronic kidney disease	25
Real-world data shows the effectiveness of a tetravalent vaccine against human papilloma virus types 16 and 18 in Chilean women	25
Three cases of false decrease interference of etamsylate on biochemical laboratory tests and correction methods	25
Monitoring mutant KRAS in plasma cell-free DNA can predict disease progression in a patient with multiple myeloma: A case report	25
Epigenetics of Diabetes: A bioinformatic approach	25
Electrochemical nanosensors for early detection of childhood cancer	24
Diagnostic value of Serum Amyloid A, Interleukin-6 in gravidas with spontaneous preterm birth	24
Seroprevalence and risk factors of toxoplasmosis among pregnant women in the M’saken region (Tunisia)	24
Optimized NMDAR autoantibody detection via combined NR1-4a LCBA and NR1/NR2 fusion FCBA	24
Plasma lipidomics reveals potential lipid markers for the prediction of delayed neurocognitive recovery after cardiac surgery with cardiopulmonary bypass	24
Recent advances in lateral flow assays for MicroRNA detection	24
Exploring strategies to rapidly identify false positives in high-sensitivity cardiac troponin I assay: A prospective study	24
Diagnosis of patients with mucopolysaccharidosis type II via RNA sequencing	24
Simultaneous determination of multiple urine biomarkers for kidney injury using SPE combined with LC-MS/MS	24
Hook-effect in MAGLUMI immunoassay for serum anti-GAD antibodies in neurological disorders: When “wrong” matrix is the right choice	23

Exosome biosensors for detection of Lung cancer	23
Exosome biosensors for detection of liver cancer	23
Lipocalin2 as a useful biomarker for risk stratification in patients with acute cholangitis: A single-center prospective and observational study	23
Saliva Speaks: A Critical Analysis of Salivary Biomarkers as an Early Oral Cancer Diagnostic Tool	23
Inflammation in maple syrup urine disease	23
The pentraxin family in autoimmune disease	23
Assay-Dependent Effects of EDTA Contamination on Magnesium and Iron	23
A novel CLPP variant in a Pakistani family with Perrault syndrome associated with recurrent fevers	22
Determination of age-specific reference intervals for ethanolamine plasmalogen species in red blood cells using liquid chromatography tandem mass spectrometry	22
The value of serum tumor-associated autoantibodies in screening and diagnosis of gastric cancer	22
Targeted plasma proteomic analysis uncovers a high-performance biomarker panel for early diagnosis of gastric cancer	22
Evaluating the effect of gestational diabetes mellitus on macrosomia based on the characteristics of oral glucose tolerance test	22
Recommendations for establishing metrological traceability for in vitro diagnostic measurement procedures intended to be used for whole blood samples	22
miRNA-based electrochemical biosensors for ovarian cancer	22
MassARRAY-based targeted detection of SLC22A5 mutations: A feasibility study for secondary screening of primary carnitine deficiency in newborns	22
Serum Gas6 contributes to clinical outcome after aneurysmal subarachnoid hemorrhage: A prospective cohort study	22
Circulating suPAR as a noninvasive biomarker of fibrosis and immune activation in autoimmune liver diseases	22
Neutrophil gelatinase-associated lipocalin in contrast-induced acute kidney injury post cardiac procedure: a systematic review	22
Quantitative analysis of soluble costimulatory molecules as potential diagnostic biomarkers for rheumatoid arthritis using LC-MS/MS in MRM mode	22
A laboratory puzzle in a “blue” adolescent: Cyanosis, discordant oxygen measurements, and interference in leukocyte differential analysis	22
Electrochemical biosensors for enhanced detection of diabetes mellitus	21
Enhancing creatinine detection: Innovative biosensors for monitoring kidney function	21
Aptamer-based electrochemical biosensors for progesterone detection: Advancing point-of-care diagnostics	21
Impact of angiotensin receptor–neprilysin inhibitor therapy on urinary C-peptide measurements: A potential pitfall in the β-cell function assessment	21
Blood biomarkers for Alzheimer’s disease with the Lumipulse automated platform: Age-effect and clinical value interpretation	21
Untargeted metabolomics analysis of the plasma metabolic signature of moderate-to-severe acne	21
Integrating CRISPR with SERS: Toward intelligent point-of-care diagnostics of the future	21
Integrating multiplex PCR in fever clinics for acute respiratory pathogen-specific diagnosis	21
Serum metabolomic profile of myasthenia gravis and potential values as biomarkers in disease monitoring	21
Plasma protein biomarkers for long COVID-19: Predictors of symptom severity and mortality risk	20
Exploration of the source of AQP4 antibody: Based on paired serum and cerebrospinal fluid samples from 98 patients	20
Multi-omics biomarker in adrenocortical carcinoma: a clinical-chemistry perspective	20
Holotranscobalamin-based algorithm for the identification of macro-vitamin B12 in analytical hypercobalaminemia	20
The value of serum glial fibrillary acidic protein as a biomarker of astrogliosis in different neurological diseases	20
Extracellular vesicle–derived protein biomarkers for breast Cancer diagnosis: a systematic review, meta-analysis, and umbrella review	20
Comparison of digital PCR systems for the analysis of liquid biopsy samples of patients affected by lung and colorectal cancer	20
Non-coding RNA biomarkers in Alzheimer’s disease	20
Boron-doped diamond electrochemical biosensors	20
Nanoparticle electrochemical biosensors for virus detection	20
The liver and blood cells are responsible for creatine kinase clearance in blood Circulation: A retrospective study among different human diseases	20
Metabolomics identifies metabolite markers in plasma and extracellular vesicles within plasma in patients with asthma	20
Identification of a novel plasma metabolite panel as diagnostic biomarker for hepatocellular carcinoma	20
Glycoprotein biomarkers for bladder cancer detection	20
An accurate measurement method for serum homocysteine measurement by ID-LC/MS/MS and the application of external quality assessment	20
Cervical cancer diagnostics: non-coding RNAs and biosensors to AI-derived methods	20
Ovarian cancer detection and prognosis: Unveiling circRNAs potential	20
Development and application of a novel aldehyde nanoparticle-based amplified luminescent proximity homogeneous assay for rapid quantitation of pancreatic stone protein	19
Biological variation of methylmalonic acid in urine in spanish population	19
“Extracellular Vesicle DNA: Advances and Applications as a Non-Invasive Biomarker in Disease Diagnosis and Treatment”	19
The double-edged role of point-of-care testing in modern medicine	19
Glycated albumin: detection methods and standardization	19
Resistin and omentin in breast cancer: A systematic review and meta-analysis	19
Comment on ‘The diagnostic value of interleukin-36 cytokines in pleural effusions of varying etiologies’	19
TQ-Oxime derivative: A promising therapeutic agent for U87 glioma cells assessment of cytotoxic and apoptotic properties	18
Stool antigen testing and serology’s accuracy in identifying helicobacter pylori infections in suspected patients	18
Procalcitonin and transferrin as a survival markers of patients with COVID-19	18
Correlation between the levels of serum C-reactive protein and plasma glycated HbA1c in diabetic patients and non-diabetic individuals in the western parts of Nepal	18
Serum concentration of placental growth factor in pregnancy screening for placental dysfunction and low molecular weight heparin treatment	18
Laboratory medicine residents in France − highly qualified, scarcely mobile	18
Editorial board member, Aims and Scope, Publication Info.	18
The biomarkers of oxidative stress – An effective tool for diagnosing COVID-19 patients and convalescents	18
Deficiency or sufficiency? A five-year analysis of calcidiol levels across age groups in the Spanish population	18
Use of point of care (POCT) c-reactive protein (CRP) to support antibiotic prescribing in primary care – Are they good enough? A review of performance on the Weqas POCT CRP programme	18
Editorial Board	18
Seroprevalence of antinuclear antibodies in patients with Hepatitis B	18
Analysis of gene mutation characteristics and its correlation with prognosis in patients with myelodysplastic syndromes	17
Analysis of two intestinal bacterial metabolites (trimethylamine N-oxide and phenylacetylglutamine) in human serum samples of patients with T2DM and AMI using a liquid chromatography tandem mass spect	17
Application of neutrophil-to-lymphocyte ratio in the diagnosis of complicated pediatric appendicitis	17
Sclerostin in ankylosing spondylitis: A meta-analysis	17
Evaluation of an enzymatic one-step assay for Beta-Hydroxybutyrate blood testing on clinical chemistry platforms using HILIC-MS/MS as a non-enzymatic reference method	17
Advantages of the implementation of a second-tier test strategy in the newborn screening	17
Overweight and obesity: The weight of genes	17
Expanding the clinical utility of reporter gene assay to infliximab biosimilars	17
Cytomegalovirus antigen-specific multi-cytokine immune responses in patients with rheumatic diseases under different cytomegalovirus infection status: A case-control study	17
Non-invasive fetal RHD genotyping in d- (RH:-1) patients with RHD genomic sequences: retrospective study over 11 years	17
The role of tubulointerstitial markers in differential diagnosis and prognosis in patients with type 2 diabetes and biopsy proven diabetic kidney disease	17
Evaluating the utility of using glycated albumin in diagnosing dysglycemia among Saudis- A pilot study	16
The role of laboratory diagnostics in determining the physical health of psychiatric inpatients	16
Mild-to-moderate COVID-19 may affect nervous system function in convalescents	16
The association of siMS and siMS risk scores with risk factors for cardiovascular events in university students with metabolic syndrome	16

Liaison MeMed BV: A new approach for a quicker diagnosis between viral and bacterial infections in a cohort of pediatric patients	16
Evaluation of the performance of biochemical ratios and albumin’s gradient in the etiological exploration of ascitic fluid	16
Distance changes of lymphocyte quantity and function in patients with COVID-19	16
Leveraging machine learning to improve current diagnostic algorithms and laboratory stewardship	16
Utility of serum indices for predicting liver fibrosis	16
Revolutionizing cell-based analyses: An electrochemical analysis platform with integrated incubator capabilities	15
Association of HIV-1 Nef polymorphisms with coronary artery disease in HIV-positive patients	15
Impact of CSF collection volume in the accuracy of Alzheimer’s disease biomarker results	15
Novel biomarkers to improve diagnosis and monitor prognosis	15
Study of teratozoospermia in our population through analysis of seminal fluid in the assisted human reproduction unit of a Spanish referral hospital	15
Strategic collaboration to address nitrous oxide challenges: Establishment of an international consortium of experts	15
Brucella outbreak linked to ice cream: A Lebanese case series	15
Apolipoprotein C-III mucin core 2 O-Linked glycoforms: Hiding in plain sight	15
Serologic profile of individuals who contracted COVID-19 despite triple vaccination	15
Clinical performance evaluation of smartchek SARS-COV-2 detection kit and smartchek SARS-COV-2 fast detection kit for detection of severe acute respiratory syndrome coronavirus 2 (SARS-COV-2) in saliv	15
Performance verification and reference interval establishment of serum/plasma aldosterone by a novel “sandwich” chemiluminescent immunoassay	15
Challenges with sweat testing – A quality improvement initiative	15
Enhancing enteric pathogen detection: implementation and impact of multiplex PCR for improved diagnosis and surveillance	15
Waste management in clinical laboratories	15
Comparison of clot waveform analysis with or without adjustment between prothrombin time and activated partial thromboplastin time assays to assess in vitro effects of direct oral anticoagulants	14
Clinical and genetic investigation in patients with permanent congenital hypothyroidism	14
Bacteriological profile and antimicrobial susceptibility patterns of organisms responsible for blood stream infections in intensive care unit patients	14
The association between the PON1 genes rs662 and rs854560 and the metabolic syndrome in patients with obesity	14
Evaluation of iron metabolism in hospitalized COVID-19 patients	14
Risk stratification and predictive value of serum sodium fluctuation for adverse prognosis in acute coronary syndrome patients	14
Association between apolipoprotein B/A1 and the risk of metabolic dysfunction associated fatty liver disease according to different lipid profiles in a Chinese population: A cross-sectional study	14
Limitations of hemolysis-based correction for potassium measurement in hemolyzed whole blood samples	14
A novel variant of the POLR3A gene in a patient with hypomyelinating POLR3-related leukodystrophy	14
Clinical implications of opioid parent-metabolite ratios	14
Integration of coagulation parameters Enhances deep Learning-Based survival prediction in High-Grade serous ovarian Cancer: A comprehensive prognostic model	14
Estimation of FGF-23 level in patients with chronic kidney disease with or without vitamin D supplementation	14
Quantification of plasma mutant calreticulin for diagnosis and therapeutic response assessment of peginterferon-α in myeloproliferative neoplasms: A proof-of-concept study	14
Proteomics of neuropsychiatric disorders	14
Tissue polypeptide antigen as a non-invasive bladder Cancer biomarker	14
Corrigendum to “The impact of triadimenol on male fertility: An in vitro study and molecular docking examination” [Reprod. Toxicol. 132 (2025) 108861]	14
Targeting tumour markers in ovarian cancer treatment	14
The clinical validation of a dried blood spot method for simultaneous measurement of cyclosporine A, tacrolimus, creatinine, and hematocrit	14
MicroRNA biomarkers for predicting treatment response and resistance to bevacizumab in cancer	14
HDL subfractions determined by microfluidic chip electrophoresis predict the vulnerability of intracranial plaque: A HRMRI study	14
Incorporating measurement uncertainty into free valproic acid monitoring: estimation and clinical impact for therapeutic drug monitoring	14
Artificial intelligence in the clinical laboratory	14
The assessment of endocannabinoids and N-acylethanolamines in human hair: Associations with sociodemographic and psychological variables	14
Serial monitoring of cytokine profile, liver function, and hematological biomarkers in severe CRS and CLS following CAR-T cell therapy for relapsed hepatocellular carcinoma: a case report	13
Validation of a liquid chromatography coupled to tandem mass spectrometry method for simultaneous quantification of tryptophan and 10 key metabolites of the kynurenine pathway in plasma and urine: App	13
Enhancing breast cancer treatment through pharmacogenomics: A narrative review	13
Electrochemical biosensors in early leukemia detection	13
Exploring the key factors of schizophrenia relapse by integrating LC-MS/1H NMR metabolomics and weighted correlation network analysis	13
Association of lipoprotein(a) with left ventricular hypertrophy in patients with new-onset acute myocardial infarction: A large cross-sectional study	13
Biosensors and lateral flow immunoassays: Current state and future prospects	13
Non-coding RNA biomarkers in cardiovascular disease	13
LC–MS/MS methods for synthetic opioids in urine: analytical and clinical evaluation	13
Pediatric reference values of NT-proBNP and Galectin-3 based on a French cohort	13
Exosomal non-coding RNA biomarkers in traumatic brain injury	13
Study of the impact of ClinGen Revisions on ACMG/AMP variant semi-automatic classification for Rare Diseases diagnosis	13
A CD3G homozygous pathogenic variant in a Chinese child with lupus-like disease, autoimmune thyroiditis and immunodeficiency	13
Association of metabolic and lipid indices with severity among patients with acute pancreatitis: A 10-year prospective registry-based cohort study with focus on hypertriglyceridemia-associated acute p	13
Trimethyllysine as a potential biomarker for heart failure	13
Metabolomic profiling of serum and tongue coating of pregnant women with intrahepatic cholestasis in pregnancy	13
Quality management, ethical considerations, and emerging challenges in genomics and biobanking: A comprehensive review	13
When urinalysis speaks first: Unexpected atypical urothelial cells revealing upper tract urothelial carcinoma	13
Relationships among maternal monosomy X mosaicism, maternal trisomy, and discordant sex chromosome aneuploidies	13
Multi-omics identification of aging-related diagnostic genes and therapeutic targets in renal fibrosis	13
Indisputable vs. questionable actionable secondary findings in a cohort of 500 Lebanese participants: What to report to the patient?	13
Fragmentation of human cardiac troponin T after acute myocardial infarction	13
An adult patient with Tatton-Brown-Rahman Syndrome: case report and novel DNMT3A variant not previously reported	13
Circulating integrins as biomarkers for bone metastasis in prostate cancer	13
A retrospective analysis of 1600 infertility patients with azoospermia and severe oligozoospermia	13
Glycated albumin is a useful marker for early screening of undiagnosed prediabetes and diabetes in patients presenting to a metropolitan emergency department	13
Evaluating the efficacy of a long-read sequencing-based approach in the clinical diagnosis of neonatal congenital adrenocortical hyperplasia	13
Reliable in-house LC-MS/MS method for steroid hormone analysis: Validations and comparisons	13
Assessment of a novel point-of-care system for chemistry panel testing	12
Dihydropyrimidine dehydrogenase phenotyping by LC-MS/MS determination of uracil in human plasma	12
Creatine and creatinine quantified using nuclear magnetic resonance: A method validation study and clinical associations between circulating creatine and fatigue in kidney transplant recipients	12
An artificial intelligence-driven support tool for prediction of urine culture test results	12
Advancing Prostate Cancer Diagnostics: The Potential of Paper-Based Biosensors for Point-of-Care Testing	12
Metabolomics study reveals blood biomarkers for early diagnosis of chronic kidney disease and IgA nephropathy: A retrospective cross-sectional study	12
Pathfast POCT: Evaluation presepsin as a key biomarker in sepsis	12
Autologous platelet-rich plasma as adjuvant treatment in patients with refractory endometrial growth: Preliminary results from a 2-year prospective study in a Spanish reference unit of assisted human	12
Deciphering biological impact of nitrous oxide abuse: Insights from targeted metabolomics analysis	12
A retrospective study about the prevalence of onconeuronal antibodies and their possible association with paraneoplastic syndromes	12
Impact of platelet activation on the release of cell-free mitochondria and circulating mitochondrial DNA	12
Point-of-care testing for early detection of sepsis: a systematic literature review	12
Atypical presentation of potter sequence associated with 46, XX testicular disorder of sex development	12
A new pitfall in potassium testing: A case series of false elevation of hemolysis index in the presence of monoclonal protein	12
Effect of monoclonal antibody interferences on vitamin B12 immunoassay measurement	12
A rare case of potter’s sequence with sex reversal in a 33 – Year old female”	12
Evaluating data accuracy in clinical laboratory requests: A therapeutic drug monitoring study	12
®-Thalassemia intermedia: implication of presenting 〈-globin gene triplication	12
Top-down mass spectrometry for in-depth analysis of protein biomarkers: A novel methodology for precision diagnostics	12
MicroRNAs in disease States	12
Thalassemia genetic screening of pregnant women with anemia in Northern China through comprehensive analysis of thalassemia alleles (CATSA)	12
JAK2 V617F as a diagnostic and prognostic biomarker in myeloproliferative neoplasms	12
Editorial Board	12
Stabilization of glucose concentration in the new vacuette® FC mix blood collection tube for diagnosis of diabetes and gestational diabetes	12
IgE sensitization to ragweed and Japanese cedar pollen due to pectate lyase	12