Clinica Chimica Acta

Article	Citations
Thrombocytopenia is associated with severe coronavirus disease 2019 (COVID-19) infections: A meta-analysis	1132
COVID-19: Transmission, prevention, and potential therapeutic opportunities	571
Positive rate of RT-PCR detection of SARS-CoV-2 infection in 4880 cases from one hospital in Wuhan, China, from Jan to Feb 2020	418
Procalcitonin in patients with severe coronavirus disease 2019 (COVID-19): A meta-analysis	411
Cytokine storm induced by SARS-CoV-2	388
Hyperinflammation and derangement of renin-angiotensin-aldosterone system in COVID-19: A novel hypothesis for clinically suspected hypercoagulopathy and microvascular immunothrombosis	269
IgA-Ab response to spike glycoprotein of SARS-CoV-2 in patients with COVID-19: A longitudinal study	258
Abnormalities of peripheral blood system in patients with COVID-19 in Wenzhou, China	223
Relationship between ABO blood group distribution and clinical characteristics in patients with COVID-19	199
Lactate dehydrogenase and C-reactive protein as predictors of respiratory failure in CoVID-19 patients	151
Hyperferritinemia in critically ill COVID-19 patients – Is ferritin the product of inflammation or a pathogenic mediator?	149
Laboratory findings in COVID-19 diagnosis and prognosis	133
The host’s angiotensin-converting enzyme polymorphism may explain epidemiological findings in COVID-19 infections	132
Declined serum high density lipoprotein cholesterol is associated with the severity of COVID-19 infection	116
Fecal microbiota transplantation in disease therapy	104
Dopamine in Parkinson's disease	99
HOTAIR LncRNA: A novel oncogenic propellant in human cancer	97
Sirtuins and intervertebral disc degeneration: Roles in inflammation, oxidative stress, and mitochondrial function	96
Laboratory diagnosis of coronavirus disease-2019 (COVID-19)	95
Comparison of the Elecsys® Anti-SARS-CoV-2 immunoassay with the EDI™ enzyme linked immunosorbent assays for the detection of SARS-CoV-2 antibodies in human plasma	94
C-reactive protein: A promising biomarker for poor prognosis in COVID-19 infection	94
Comparative analysis of laboratory indexes of severe and non-severe patients infected with COVID-19	94
Pyroptosis: A pro-inflammatory type of cell death in cardiovascular disease	93
Diagnostic performances and thresholds: The key to harmonization in serological SARS-CoV-2 assays?	92
Bnip3 in mitophagy: Novel insights and potential therapeutic target for diseases of secondary mitochondrial dysfunction	89

Soluble ST2: A complex and diverse role in several diseases	79
Circulating microRNAs: Biomarkers of disease	77
circRNA-miRNA-mRNA in breast cancer	77
Highly sensitive detection of SARS-CoV-2 RNA by multiplex rRT-PCR for molecular diagnosis of COVID-19 by clinical laboratories	77
Decreased T cell populations contribute to the increased severity of COVID-19	76
Antibody response to first and second dose of BNT162b2 in a cohort of characterized healthcare workers	73
Butyrate-producing bacteria and the gut-heart axis in atherosclerosis	71
Laboratory data analysis of novel coronavirus (COVID-19) screening in 2510 patients	67
The exchangeable apolipoproteins in lipid metabolism and obesity	66
Value of leukocytosis and elevated C-reactive protein in predicting severe coronavirus 2019 (COVID-19): A systematic review and meta-analysis	63
Presepsin in risk stratification of SARS-CoV-2 patients	60
Salivary SARS-CoV-2 antigen rapid detection: A prospective cohort study	58
Dynamic changes in routine blood parameters of a severe COVID-19 case	58
The PrecivityAD™ test: Accurate and reliable LC-MS/MS assays for quantifying plasma amyloid beta 40 and 42 and apolipoprotein E proteotype for the assessment of brain amyloidosis	58
SARS-CoV-2 identification and IgA antibodies in saliva: One sample two tests approach for diagnosis	57
The underlying changes and predicting role of peripheral blood inflammatory cells in severe COVID-19 patients: A sentinel?	57
rRT-PCR for SARS-CoV-2: Analytical considerations	57
Calprotectin in inflammatory bowel disease	56
Recent advances in robotic protein sample preparation for clinical analysis and other biomedical applications	55
Droplet digital PCR as an emerging tool in detecting pathogens nucleic acids in infectious diseases	55
ACE deletion allele is associated with susceptibility to SARS-CoV-2 infection and mortality rate: An epidemiological study in the Asian population	55
Cardiac biomarkers of heart failure in chronic kidney disease	52
Iron overload: Effects on cellular biochemistry	51
Mitochondrial iron metabolism and its role in diseases	47
Nrf2 in early vascular ageing: Calcification, senescence and therapy	46
Evaluation of Abbott anti-SARS-CoV-2 CMIA IgG and Euroimmun ELISA IgG/IgA assays in a clinical lab	44
Long non-coding RNA in lung cancer	43
Cell free DNA as a diagnostic and prognostic marker for cardiovascular diseases	42
Adrenal insufficiency: Physiology, clinical presentation and diagnostic challenges	42
Elevated monocyte distribution width in COVID-19 patients: The contribution of the novel sepsis indicator	42
Potential of nano-phytochemicals in cervical cancer therapy	42
Long non-coding RNAs and pyroptosis	42
Dynamic change process of target genes by RT-PCR testing of SARS-Cov-2 during the course of a Coronavirus Disease 2019 patient	40
COVID-19: Review and hematologic impact	40
Triglyceride metabolism and angiopoietin-like proteins in lipoprotein lipase regulation	40
Pyroptosis in diabetic nephropathy	40
Emerging biomarkers in Multiple Myeloma: A review	39
Comparison of test performance of commercial anti-SARS-CoV-2 immunoassays in serum and plasma samples	39
Lipid metabolism changes in patients with severe COVID-19	39
SARS-CoV-2 antibody characterization in emergency department, hospitalized and convalescent patients by two semi-quantitative immunoassays	38
Resistin: Potential biomarker and therapeutic target in atherosclerosis	38
Exhaled breath analysis in disease detection	38
COX-2 in liver fibrosis	38
Small dense low-density lipoprotein: Analytical review	36
Advances in lipidomics	36
Hyperlipidemia and hypothyroidism	35
Detection of COPD and Lung Cancer with electronic nose using ensemble learning methods	35
Immune regulation in polycystic ovary syndrome	34
Diagnostic and prognostic value of the cancer-testis antigen lactate dehydrogenase C4 in breast cancer	34
Evaluation of the EDI enzyme linked immunosorbent assays for the detection of SARS-CoV-2 IgM and IgG antibodies in human plasma	34

Traditional and modern management strategies for rheumatoid arthritis	34
ACE I/D polymorphism in Czech first-wave SARS-CoV-2-positive survivors	33
Potential diagnostics and therapeutic approaches in COVID-19	33
More accurate LDL-C calculation: Externally validated, guideline endorsed	32
Angiotensin converting enzyme (ACE)	32
Advances in prostate specific antigen biosensors-impact of nanotechnology	32
Revealing the role of glycerophospholipid metabolism in asthma through plasma lipidomics	32
MicroRNAs in venous thrombo-embolism	31
MicroRNA in multiple sclerosis	31
Elevated systemic immune inflammation index level is associated with disease activity in ulcerative colitis patients	31
Adipokines as novel biomarkers of cardio-metabolic disorders	31
Endoplasmic reticulum stress and focused drug discovery in cardiovascular disease	31
Comparison of qualitative and quantitative analyses of COVID-19 clinical samples	31
Oncogenic miRNAs and target therapies in colorectal cancer	31
Recommendations on the measurement and the clinical use of vitamin D metabolites and vitamin D binding protein – A position paper from the IFCC Committee on bone metabolism	31
Long non-coding RNA in bladder cancer	31
An evidence for correlation between the glutathione S-transferase T1 (GSTT1) polymorphism and outcome of COVID-19	31
Standardization process of continuous glucose monitoring: Traceability and performance	31
Short-term biological variation and diurnal rhythm of cardiac troponin I (Access hs-TnI) in healthy subjects	30
The diagnostic and prognostic role of myocardial injury biomarkers in hospitalized patients with COVID-19	30
Analytical considerations and plans to standardize or harmonize assays for the reference bone turnover markers PINP and β-CTX in blood	30
The ABCA1-efferocytosis axis: A new strategy to protect against atherosclerosis	29
IgG antibodies against SARS-CoV-2 decay but persist 4 months after vaccination in a cohort of healthcare workers	29
The circadian clock and inflammation: A new insight	29
Antibodies against severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) in individuals with and without COVID-19 vaccination: A method comparison of two different commercially available s	29
Oxidative stress in vascular calcification	29
Role of SNHG16 in human cancer	29
Prognostic value of changes in neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR) and lymphocyte-to-monocyte ratio (LMR) for patients with cervical cancer undergoing definitive c	29
The endothelin system as target for therapeutic interventions in cardiovascular and renal disease	29
Potentiometric urea biosensors	29
Mechanisms of cancer stem cell therapy	28
Clinical laboratory evaluation of COVID-19	28
Impact of heat-inactivation on the detection of SARS-CoV-2 IgM and IgG antibody by ELISA	28
Stress and neurodegeneration	28
The diagnostic value of serum C-reactive protein, procalcitonin, interleukin-6 and lactate dehydrogenase in patients with severe acute pancreatitis	28
Endogenous ApoA-I expression in macrophages: A potential target for protection against atherosclerosis	28
The clinical utility of apoB versus LDL-C/non-HDL-C	27
The red blood cell distribution width-albumin ratio: A promising predictor of mortality in heart failure patients — A cohort study	27
Harmonization of six quantitative SARS-CoV-2 serological assays using sera of vaccinated subjects	27
Mitophagy in cardiovascular disease	26
Early kinetic profiles of troponin I and T measured by high-sensitivity assays in patients with myocardial infarction	26
Iron metabolism and the exocrine pancreas	26
Comparison of reference intervals derived by direct and indirect methods based on compatible datasets obtained in Turkey	26
Biosensors in Parkinson’s disease	26
Application of chemoresistive gas sensors and chemometric analysis to differentiate the fingerprints of global volatile organic compounds from diseases. Preliminary results of COPD, lung cancer and br	26
Emerging role of Insig-1 in lipid metabolism and lipid disorders	25
The trends in nanomaterial-based biosensors for detecting critical biomarkers in stroke	25
A novel plasma based early colorectal cancer screening assay base on methylated SDC2 and SFRP2	25
Bone, inflammation and chronic kidney disease	25
Update on serologic testing in COVID–19	25
Chemerin in inflammatory diseases	25
Reference interval of monocyte distribution width (MDW) in healthy blood donors	25
The DNA replication regulator MCM6: An emerging cancer biomarker and target	24
Ceramides improve atherosclerotic cardiovascular disease risk assessment beyond standard risk factors	24
Serum D-dimer as a diagnostic index of PJI and retrospective analysis of etiology in patients with PJI	24
Surface plasmon resonance: A promising approach for label-free early cancer diagnosis	24
Biochemistry of infertility	24
Correlation of Krebs von den Lungen-6 and fibronectin with pulmonary fibrosis in coronavirus disease 2019	23
Collaborative AI and Laboratory Medicine integration in precision cardiovascular medicine	23
Identification of potential urine biomarkers in idiopathic parkinson's disease using NMR	23
Advances in drugs of abuse testing	23
Development and performance of a next generation sequencing (NGS) assay for monitoring of mixed chimerism	22
The role of fibrinogen to albumin ratio in ankylosing spondylitis: Correlation with disease activity	22
Quantification of free and protein bound uremic toxins in human serum by LC-MS/MS: Comparison of rapid equilibrium dialysis and ultrafiltration	22
Screening 3.4 million newborns for primary carnitine deficiency in Zhejiang Province, China	22
Reticulocyte hemoglobin content	22
COVID-19 infection and thrombosis	22
Lactic acid in tumor invasion	22
PD-1/PD-L1 in cardiovascular disease	22
Neutrophil gelatinase-associated lipocalin (NGAL) in kidney injury – A systematic review	22
Epigenetic factors in atherosclerosis: DNA methylation, folic acid metabolism, and intestinal microbiota	22
Relationship between the plasma acylcarnitine profile and cardiometabolic risk factors in adults diagnosed with cardiovascular diseases	22
Albumin corrected anion gap for predicting in-hospital mortality among intensive care patients with sepsis: A retrospective propensity score matching analysis	22
Neutrophil extracellular traps and organ dysfunction in sepsis	22
Endometrial cancer: A systematic review of HE4, REM and REM-B	21
Chemerin in immune response and gastrointestinal pathophysiology	21
Bioassay: A novel approach in antipsychotic pharmacology	21
Heterogeneous nuclear ribonucleoprotein (hnRNPL) in cancer	21
The S100 protein family in lung cancer	21
Electrochemical prostate-specific antigen biosensors based on electroconductive nanomaterials and polymers	21

Serum specific IgE antibodies in immediate drug hypersensitivity	21
YKL-40 as a novel biomarker in cardio-metabolic disorders and inflammatory diseases	21
Serum metabolite signatures of epithelial ovarian cancer based on targeted metabolomics	20
Assessment of patient-based real-time quality control algorithm performance on different types of analytical error	20
PLA2G10 incorporated in exosomes could be diagnostic and prognostic biomarker for non-small cell lung cancer	20
NAD+ and cardiovascular diseases	20
What do we need to obtain high quality circulating tumor DNA (ctDNA) for routine diagnostic test in oncology? – Considerations on pre-analytical aspects by the IFCC workgroup cfDNA	20
Endocan: A novel biomarker for risk stratification, prognosis and therapeutic monitoring in human cardiovascular and renal diseases	20
Exosomal analysis: Advances in biosensor technology	20
Acute aluminum phosphide poisoning: The menace of phosphine exposure	20
Evaluation of the necessity and the feasibility of the standardization of procalcitonin measurements: Activities of IFCC WG-PCT with involvement of all stakeholders	20
Long non-coding RNA HCP5 in cancer	20
LC-MS/MS and SWATH based serum metabolomics enables biomarker discovery in pancreatic cancer	19
ICAM-1 and VCAM-1: Gatekeepers in various inflammatory and cardiovascular disorders	19
Cardiac troponin I in SARS-CoV-2-patients: The additional prognostic value of serial monitoring	19
Performance of an automated chemiluminescence SARS-CoV-2 IG-G assay	19
The role of TPS, CA125, CA15-3 and CEA in prediction of distant metastasis of breast cancer	19
Inappropriate use of laboratory tests: How availability triggers demand – Examples across Europe	19
Omentin-1: Protective impact on ischemic stroke via ameliorating atherosclerosis	19
Comparison of two digital PCR methods for EGFR DNA and SARS-CoV-2 RNA quantification	19
The epitranscriptome of long noncoding RNAs in metabolic diseases	19
Prognostic value of combined preoperative fibrinogen-albumin ratio and platelet-lymphocyte ratio score in patients with breast cancer: A prognostic nomogram study	19
Diagnosing acute promyelocytic leukemia by using convolutional neural network	19
SARS-CoV-2 neutralizing antibodies after one or two doses of Comirnaty (BNT162b2, BioNTech/Pfizer): Kinetics and comparison with chemiluminescent assays	18
Glycoprotein biomarkers and analysis in chronic obstructive pulmonary disease and lung cancer with special focus on serum immunoglobulin G	18
The French paradox three decades later: Role of inflammation and thrombosis	18
High prevalence of xylazine among fentanyl screen-positive urines from hospitalized patients, Philadelphia, 2021	18
14-3-3 σ: A potential biomolecule for cancer therapy	18
Can environmental pollutant bisphenol A increase metabolic risk in polycystic ovary syndrome?	18
The bone-vessel axis in chronic kidney disease: An update on biochemical players and its future role in laboratory medicine	18
Autophagy in chronic stress induced atherosclerosis	18
LC-MS/MS method for nine different antibiotics	18
Role of Kruppel-like factor 4 in atherosclerosis	18
CCR5 Δ32 minorallele is associated with susceptibility to SARS-CoV-2 infection and death: An epidemiological investigation	18
SARS-CoV-2 infection serology validation of different methods: Usefulness of IgA in the early phase of infection	18
Droplet digital PCR for large genomic rearrangements detection: A promising strategy in tissue BRCA1 testing	18
Assessment of tryptophan and kynurenine as prognostic markers in patients with SARS-CoV-2	18
Saliva for use with a point of care assay for the rapid diagnosis of COVID-19	18
Circular RNAs in nasopharyngeal carcinoma	17
Sumoylation in liver disease	17
Oxidation of parathyroid hormone	17
Do cytokines correlate with refractory Kawasaki disease in children?	17
Prenatal diagnosis of skeletal dysplasias using whole exome sequencing in China	17
Positive control synthesis method for COVID-19 diagnosis by one-step real-time RT-PCR	17
Uric acid and kidney damage in systemic lupus erythematosus	17
Circulating calprotectin as biomarker in neutrophil-related inflammation: Pre-analytical recommendations and reference values according to sample type	17
Hematocrit and standardization in DBS analysis: A practical approach for hormones mainly present in the plasma fraction	16
Quantifying apolipoprotein(a) in the era of proteoforms and precision medicine	16
Recent advances in the regulation of ABCA1 and ABCG1 by lncRNAs	16
Prenatal diagnosis and outcome of fetal hyperechogenic kidneys in the era of antenatal next-generation sequencing	16
Evaluation of interference from hemoglobin C, D, E and S traits on measurements of hemoglobin A1c by fifteen methods	16
Insight into osteoarthritis through integrative analysis of metabolomics and transcriptomics	16
Plasma metabolites, especially lipid metabolites, are altered in pregnant women with gestational diabetes mellitus	16
LncRNAs in Osteoarthritis	16
Evaluation of the clinical performance of single-, dual-, and triple-target SARS-CoV-2 RT-qPCR methods	16
Pathophysiology and immunogenetics of celiac disease	16
Correlation between cytokines and coagulation-related parameters in patients with coronavirus disease 2019 admitted to ICU	16
Annexin A1: A double-edged sword as novel cancer biomarker	16
Digital PCR is a sensitive new technique for SARS-CoV-2 detection in clinical applications	16
Acute kidney injury biomarkers in the critically ill	16
Ethical and organizational considerations for mandatory COVID-19 vaccination of health care workers: A clinical laboratorian's perspective	16
Exosomal noncoding RNAs in prostate cancer	16
Faecal immunochemical tests for haemoglobin: Analytical challenges and potential solutions	16
Hock-a-loogie saliva as a diagnostic specimen for SARS-CoV-2 by a PCR-based assay: A diagnostic validity study	16
Macrocomplexes and high-sensitivity cardiac troponin assays in samples stored for over 15 years	16
Lumican, pro-tumorigenic or anti-tumorigenic: A conundrum	16
Performance verification of five commercial RT-qPCR diagnostic kits for SARS-CoV-2	16
High risk screening for Gaucher disease in patients with splenomegaly and/or thrombocytopenia in China: 55 cases identified	15
Use of data mining in the establishment of age-adjusted reference intervals for parathyroid hormone	15
ITIH4 is a novel serum biomarker for early gastric cancer diagnosis	15
Comparison of estimated glomerular filtration rates in Chinese patients with chronic kidney disease among serum creatinine-, cystatin-C- and creatinine-cystatin-C-based equations: A retrospective cros	15
Analytical validation of the droplet digital PCR assay for diagnosis of spinal muscular atrophy	15
Higher ANGPTL3, apoC-III, and apoB48 dyslipidemia, and lower lipoprotein lipase concentrations are associated with dysfunctional visceral fat in adolescents with obesity	15
Cell metabolic profiling of colorectal cancer via 1H NMR	15
α-Synuclein in Parkinson's disease and advances in detection	15
Necroptosis in atherosclerosis	15
Calculating estimated glomerular filtration rate without the race correction factor: Observations at a large academic medical system	15
Estimation of low-density lipoprotein cholesterol by machine learning methods	15
Prognostic efficacy of preoperative mGPS, SIS and LCS in patients with gastric cancer	15
Long-term decay of anti-RBD IgG titers after BNT162b2 vaccination is not mirrored by loss of neutralizing bioactivity against SARS-CoV-2	15
A machine learning model for the prediction of down syndrome in second trimester antenatal screening	15
Near-infrared-based hematocrit prediction of dried blood spots: An in-depth evaluation	15
Pyroptosis in diabetes and diabetic nephropathy	15
Single-cell sequencing technology in tumor research	15
Plasma neurofilament light chain (NfL) reference interval determination in an Age-stratified cognitively unimpaired cohort	14
Utility of serum amyloid A as a potential prognostic biomarker of acute primary basal ganglia hemorrhage	14
Differences of SARS-CoV-2 serological test performance between hospitalized and outpatient COVID-19 cases	14
P-tau217 in Alzheimer’s disease	14
Cardiac biomarker measurement by point of care testing – Development, rationale, current state and future developments	14
Less expression of CD4+ and CD8+ T cells might reflect the severity of infection and predict worse prognosis in patients with COVID-19: Evidence from a pooled analysis	14
Novel and recurrent variants identified in fetuses with central nervous system abnormalities by trios-medical exome sequencing	14
Monocyte lymphocyte ratio predicts the new-onset of chronic kidney disease: A cohort study	14
Evaluation of volumetric blood collection devices for the measurement of phenylalanine and tyrosine to monitor patients with phenylketonuria	14
Comparative analysis of chemical breath-prints through olfactory technology for the discrimination between SARS-CoV-2 infected patients and controls	14
Multi-omics analysis of tumor mutation burden combined with immune infiltrates in melanoma	14