Clinica Chimica Acta

Article	Citations
Evaluating the clinical effectiveness of cardiovascular precision diagnostics	345
Performance evaluation and validation of high-performance liquid chromatography method for the quantification vitamins A and E	128
How did the COVID-19 pandemic impact drug trends?	101
Assessment of an analysing system for the determination of NA+, K+, CL- and CA2+	86
Determine the pharmacokinetics (half-life, volume of distribution and clearance) of AMB-FUBINACA in blood samples of rats using GC-MS/MS	68
Effects of obesity on liver function in children	67
The increased sensitivity of the Xpert® Xpress assay in detecting SARS-COV-2, compared to the COBAS® assay, can be attributed to the nucleocapsid gene target	58
Interference of hemolysis in urgent clinical biochemistry examinations analyzed on DxC 700 AU and access 2	58
Pre-analytical issues in haemostasis	50
Performance evaluation of the architect hepatitis c core antigen assay vs roche HCV DUO	47
Exploring artificial intelligence techniques for morphological analysis of digital images of peripheral blood cells: MC-80 versus HemaVision	46
Laboratory-based study of newborn with intrauterine growth restriction	46
New insights in the newborn screening for methylmalonic aciduria in the Balearic Islands: Surprisingly high prevalence of CD320 gene mutation (transcobalamin receptor)	42
Indeterminate results in quantiferon-TB gold plus testing: Possible explanation and predictive parameters	41
Association of miRNA-126 cycle threshold values with the blood glucose concentration	40
Treating red blood cells with dithiothreitol can help eliminate daratumumab interference in blood compatibility tests (pretransfusion testing)	40
Hypocalcemia and hypomagnesemia among patients with depression attending KFMMC-Dhahran-KSA	40
Improving of test utilization through modification of the electronic ordering system for blood zinc level	38
The effect of calcium chloride on the release of platelet-derived growth factor-BB in the platelet-rich plasma products	38
Evaluation of beta glucan test using kinetic turbidimetric method on toxinometer MT-6500 for detection of invasive fungal infections in hospitalized patients	36
Evaluation of pre-analytical quality indicators by six sigma principle: Experience at a tertiary care hospital	35
Unveiling liquid markers: The diagnostic revolution in early detection of pancreatic cancer through liquid biopsy	35
Evaluation OF FGF-23 as a marker of mineral bone disease among newly diagnosed chronic kidney disease patients in a Nigerian hospital	35
Evaluation of metabolic and endocrine profiles in the elderly	34
Association of ECM remodelling marker gene polymorphisms and their serum levels in acute and recurrent myocardial infarction	34

Exploring the potency of Lamiaceae essential oils: Chemical composition and antibacterial efficacy against multidrug-resistant bacteri	34
Immunoglobulin fragmentation challenges the interpretation of capillary protein electrophoresis results	34
Association of single nucleotide polymorphisms in eNOS gene with development of diabetic nephropathy: A case control study	34
A variant reclassification of SLC12A3 of Gitelman syndrome	33
Estimation of glomerular filtration rate with cystatin C in the evaluation of cardiovascular risk	33
Stability of arterial and venous gas samples stored for 20, 40 and 60 minutes after collection	33
“Revolutionizing emergency care: A comparative analysis of comprehensive point-of-care test panels vs conventional laboratory processes in the critical care& emergency medicine”	33
Not one-size-fits-all: The types and varieties of dtc tests and their potential harms	32
Uric acid lithiasis in southern Tunisia	32
Why do scientists call for action against vitamin D deficiency and what is behind the scene?	32
Principle of flow cytometry and issues in diagnosis	31
Study of the association between vitamin D and anti-mullerian hormone (AMH)	31
A system troubleshooting for HIV-1 drug resistance genotyping amplification rate failure at Ethiopian public health institute HIV laboratory	31
The reality of antimicrobial resistance (AMR) in Palestine and its impact on health and economy: A cross-sectional study in West Bank, Palestine	31
Cardiorenal syndrome and diabetes mellitus in indonesian population	29
Testosterone II (TSTII) and dimension VISTA® LOCI total testosterone (TTST) immunoassays meet the CDC host certification requirements for more than four years	28
Next step in predictive medicine: New serum biomarkers to predict acute stroke mortality	27
Strategy to improve the turn around time (TAT) for stat samples in clinical laboratories	27
Raman spectroscopic analysis of urine combined with machine learning identifies life-threatening inborn errors of metabolism	27
Thyroid profile abnormalities among patients tested at the Nairobi Hospital Laboratory, Kenya	27
Changes in nonalcoholic fatty liver disease and M2BPHI due to lifestyle intervention in primary healthcare	26
Hematological malignancies: Analysis of complete blood count (CBC) and myelogram results in the Hematology Laboratory of Hedi Chaker Hospital Sfax (South Tunisia)	26
Antibiotic resistance profile of enterobacteriaceae isolated from infected hemodialysis catheters	26
Editorial Board	26
Interference in the detection of HBA1C: Detection of abnormal HB presence	26
Detection of mycobacterium tuberculosis and rifampicin resistance with Xpert® MTB/RIF analysis in a tertiary hospital	26
Editorial Board	26
Comparison of various E-GFR equations in estimating glomerular filtration rate in Indians	26
Glycoprotein biomarkers for bladder cancer detection	25
Integrating multiplex PCR in fever clinics for acute respiratory pathogen-specific diagnosis	25
Identification of cell cycle-related hub genes HMMR AND CDC25C for prognosis of head and neck squamous cell carcinoma through co-expression network analysis	25
Boron-doped diamond electrochemical biosensors	25
Urinary iodine testing practices in China: Results of the 5-year external quality assessment program	25
MicroRNA regulators of vascular pathophysiology in chronic kidney disease	25
Lipocalin2 as a useful biomarker for risk stratification in patients with acute cholangitis: A single-center prospective and observational study	25
Monitoring mutant KRAS in plasma cell-free DNA can predict disease progression in a patient with multiple myeloma: A case report	25
Editorial Board	25
M085 Determinants of systemic immunity to invasive salmonella infection in endemic settings	24
Identification of a novel plasma metabolite panel as diagnostic biomarker for hepatocellular carcinoma	24
T287 The change for qualitative balance of vascular endothelial growth factor-a may contribute to therapeutic efficacy for an anti-neutrophil cytoplasmic antibody associated vasculitis subtypes	24
T274 Natural killer cell subsets and phenotypic expression of markers of activation, maturation and associated with slow progression of HIV in HAART naïve HIV patients in Addis Ababa, Ethiopia	24
T134 Establishment of algorithms and threshold of thyroid stimulating immunoglobulin for diagnosis of Graves’ disease by data mining: A Chinese multicenter study	24
Non-coding RNA biomarkers in Alzheimer’s disease	24
The value of serum glial fibrillary acidic protein as a biomarker of astrogliosis in different neurological diseases	24
Evaluation of a batched-extraction method for measurement of sirolimus, tacrolimus, and cyclosporine on the Architect i2000SR	23
W090 Effect of carbapenemase, qace, qace⊗1, and cepa genes on chlorhexidine sensitivity in clinical isolates of gram-negative bacteria with multiple resistance	23
T223 Validation and clinical application of a novel platelet function analyzer (ANYSIS 200) in cardiology patients	23
M003 Cytogenetic mechanisms of the aortic coarctation formation and their relationship with late postoperative complications	23
T052 Tumor marker study in pleural fluid and tumor heterogeneity	23
W080 Nanoparticle-enhanced digitof for detection of e. coli directly from urine	23

W139 Molecular characterization of glucose 6-phosphate dehydrogenase deficiency among selected populations in malaria endemic area of Ethiopia	23
Development of exploratory algorithms to aid in risk of malignancy prediction of indeterminate pulmonary nodules	23
M251 Potential reference measurement procedure— Determination of c-reactive protein in serum by isotope dilution mass spectrometry based on enzyme digestion	23
W058 Salmonella infection among the suspected enteric fever patients	23
W089 Emerging threat of biofilm producing MDR acinetobactercalcoaceticusbaumanniicomplex clinical isolates causing healthcare associated infections in a teaching hospital in Nepal	23
W163 Effects of cassava processing methods on insulin index, glyceamic profile, glyceamic load and index of cassava (manihot esculeuta) meals in type 2 diabetes mellitus patients seen in Benue State U	23
T258 Investigation of genetic biomarkers associated with low platelet count in normal karyotype acute myeloid leukemia	23
M102 Laboratory errors in clinical biochemistry: The quality of laboratory testing in B.P. Koirala institute of health sciences, Nepal	22
W264 A survey on RBC transfusion practice in Korea	22
T022 The role of antioxidant therapy in the symptomatic treatment of pancreatic cancer patients	22
T124 Hormonal biomarkers associated with in-hospital mortality in therapeutic hypothermia after cardiac arrest: A case series	22
T215 About a case: Crioaglutinine disease	22
T040 Micrornas stimulate prostate cancer stem cell expansion by targeting genes of the apoptotic pathway	22
Functional characterization of novel variants found in patients with suspected Fabry disease	22
Editorial board member, Aims and Scope, Publication Info.	22
M208 Pakistan inherited metabolic disorders network (PAK-IMD-NET): Breaking silos and bringing synergies	22
M080 Tinea unguium, tinea cruris and tinea corporis caused by trichophyton rurbum in HIV patient: A case report	21
Real-world data shows the effectiveness of a tetravalent vaccine against human papilloma virus types 16 and 18 in Chilean women	21
Recent advances in lateral flow assays for MicroRNA detection	21
Evaluation of a rapid immunochromatographic diagnostic test for heparin-induced thrombocytopenia: validation of delayed test and whole blood test	21
M062 Identification of biomarkers in patients with colorectal cancer in Kazakh population	21
Targeted plasma proteomic analysis uncovers a high-performance biomarker panel for early diagnosis of gastric cancer	21
Epigenetics of Diabetes: A bioinformatic approach	21
T195 Plasma creatinine measurement in diabetic patients. Should we advocate the enzymatic method?	21
Development and application of a novel aldehyde nanoparticle-based amplified luminescent proximity homogeneous assay for rapid quantitation of pancreatic stone protein	21
Unexpectedly low hemoglobin A1c in a patient with chronic lymphocytic leukemia	21
Circulating suPAR as a noninvasive biomarker of fibrosis and immune activation in autoimmune liver diseases	21
Aptamer-based electrochemical biosensors for progesterone detection: Advancing point-of-care diagnostics	20
Saliva Speaks: A Critical Analysis of Salivary Biomarkers as an Early Oral Cancer Diagnostic Tool	20
Metabolomics identifies metabolite markers in plasma and extracellular vesicles within plasma in patients with asthma	20
“Extracellular Vesicle DNA: Advances and Applications as a Non-Invasive Biomarker in Disease Diagnosis and Treatment”	20
The pentraxin family in autoimmune disease	20
Blood biomarkers for Alzheimer’s disease with the Lumipulse automated platform: Age-effect and clinical value interpretation	20
Serum Gas6 contributes to clinical outcome after aneurysmal subarachnoid hemorrhage: A prospective cohort study	20
Untargeted metabolomics analysis of the plasma metabolic signature of moderate-to-severe acne	20
Plasma protein biomarkers for long COVID-19: Predictors of symptom severity and mortality risk	20
The value of serum tumor-associated autoantibodies in screening and diagnosis of gastric cancer	19
Plasma lipidomics reveals potential lipid markers for the prediction of delayed neurocognitive recovery after cardiac surgery with cardiopulmonary bypass	19
Enhancing creatinine detection: Innovative biosensors for monitoring kidney function	19
Quantitative analysis of soluble costimulatory molecules as potential diagnostic biomarkers for rheumatoid arthritis using LC-MS/MS in MRM mode	19
Three cases of false decrease interference of etamsylate on biochemical laboratory tests and correction methods	19
Diagnostic value of Serum Amyloid A, Interleukin-6 in gravidas with spontaneous preterm birth	19
Analysis of the diagnostic and prognostic value of serum PAD2 in patients with sepsis in the intensive care unit	19
Inflammation in maple syrup urine disease	19
Serum metabolomic profile of myasthenia gravis and potential values as biomarkers in disease monitoring	19
Resistin and omentin in breast cancer: A systematic review and meta-analysis	19
Simultaneous determination of multiple urine biomarkers for kidney injury using SPE combined with LC-MS/MS	18
Exosome biosensors for detection of Lung cancer	18
Optimized NMDAR autoantibody detection via combined NR1-4a LCBA and NR1/NR2 fusion FCBA	18
Diagnosis of patients with mucopolysaccharidosis type II via RNA sequencing	18
Cervical cancer diagnostics: non-coding RNAs and biosensors to AI-derived methods	18
Seroprevalence and risk factors of toxoplasmosis among pregnant women in the M’saken region (Tunisia)	18
Exosome biosensors for detection of liver cancer	18
An accurate measurement method for serum homocysteine measurement by ID-LC/MS/MS and the application of external quality assessment	18
Electrochemical nanosensors for early detection of childhood cancer	18
Electrochemical biosensors for enhanced detection of diabetes mellitus	18
Assay-Dependent Effects of EDTA Contamination on Magnesium and Iron	18
miRNA-based electrochemical biosensors for ovarian cancer	18
Ovarian cancer detection and prognosis: Unveiling circRNAs potential	18
Exploring strategies to rapidly identify false positives in high-sensitivity cardiac troponin I assay: A prospective study	17
Exploration of the source of AQP4 antibody: Based on paired serum and cerebrospinal fluid samples from 98 patients	17
The double-edged role of point-of-care testing in modern medicine	17
Glycated albumin: detection methods and standardization	17
Nanoparticle electrochemical biosensors for virus detection	17
Integrating CRISPR with SERS: Toward intelligent point-of-care diagnostics of the future	17
The liver and blood cells are responsible for creatine kinase clearance in blood Circulation: A retrospective study among different human diseases	17
A novel CLPP variant in a Pakistani family with Perrault syndrome associated with recurrent fevers	17
Hook-effect in MAGLUMI immunoassay for serum anti-GAD antibodies in neurological disorders: When “wrong” matrix is the right choice	17
Comparison of digital PCR systems for the analysis of liquid biopsy samples of patients affected by lung and colorectal cancer	17
Comment on ‘The diagnostic value of interleukin-36 cytokines in pleural effusions of varying etiologies’	17
Evaluating the effect of gestational diabetes mellitus on macrosomia based on the characteristics of oral glucose tolerance test	17
Biological variation of methylmalonic acid in urine in spanish population	16
Deficiency or sufficiency? A five-year analysis of calcidiol levels across age groups in the Spanish population	16
TQ-Oxime derivative: A promising therapeutic agent for U87 glioma cells assessment of cytotoxic and apoptotic properties	16
The biomarkers of oxidative stress – An effective tool for diagnosing COVID-19 patients and convalescents	16
Stool antigen testing and serology’s accuracy in identifying helicobacter pylori infections in suspected patients	16
Use of point of care (POCT) c-reactive protein (CRP) to support antibiotic prescribing in primary care – Are they good enough? A review of performance on the Weqas POCT CRP programme	16
Serum concentration of placental growth factor in pregnancy screening for placental dysfunction and low molecular weight heparin treatment	16
Seroprevalence of antinuclear antibodies in patients with Hepatitis B	16
Laboratory medicine residents in France − highly qualified, scarcely mobile	16

Correlation between the levels of serum C-reactive protein and plasma glycated HbA1c in diabetic patients and non-diabetic individuals in the western parts of Nepal	16
T104 An accuracy of blood glucose obtained from glucose meter [LDQUO]Standard Gluconavii® GDH Blood Glucose Meter[RDQUO] by testing with arterial and neonatal blood samples	15
T021 Nagalase – New laboratory test for the discovery of malignancy and some serious viral diseases	15
Editorial board member, Aims and Scope, Publication Info.	15
W157 Prostaglandin-D-synthase levels in cerebrospinal fluid associated with altered tau proteins in patients with suspected Alzheimer’s disease	15
T181 Establishment of influence factors and ageing models for thyroid hormones in the elderly using real-world big data	15
T017 Analytical and clinical assessment of prostate specific antigen by chemiluminescence HISCL-5000 immunoassay	15
T129 Stability of arterial blood gases (ABG)	15
T170 Three cases of endocrine immune-related adverse events caused by immune checkpoint inhibitor therapy	15
M200 Evaluation of eight commercially available clinical chemistry assays on the ALINITY® C system	15
T079 High sensitive troponin assays in differentiating acute coronary syndrome from healthy individuals	15
T201 The liver enzymes in patients with cirrhosis and hepatocellular carcinoma (HCC)	15
W014 About a case of rhabdomyolysis in a 7 year-old child secondary to a deficiency of very long-chain acyl-coa dehydrogenase (VLCAD)	15
T257 Blood coagulation testing and hematological features of thalassemia carriers in pregnant	15
LIS requirements for laboratory management	15
Editorial Board	15
M052 Evaluation of extracellular fatty acid synthase and copeptin in obesity induced insulin resistance and metabolic syndrome	15
W055 Serum erythroferrone in chronic kidney disease patients	15
Advantages of the implementation of a second-tier test strategy in the newborn screening	14
Exosomal non-coding RNA biomarkers in traumatic brain injury	14
W224 Is there a relationship between seminal zinc concentration and sperm quality in overweight men?	14
Procalcitonin and transferrin as a survival markers of patients with COVID-19	14
Expanding the clinical utility of reporter gene assay to infliximab biosimilars	14
Glycated albumin is a useful marker for early screening of undiagnosed prediabetes and diabetes in patients presenting to a metropolitan emergency department	14
Cytomegalovirus antigen-specific multi-cytokine immune responses in patients with rheumatic diseases under different cytomegalovirus infection status: A case-control study	14
Application of neutrophil-to-lymphocyte ratio in the diagnosis of complicated pediatric appendicitis	14
Evaluating the utility of using glycated albumin in diagnosing dysglycemia among Saudis- A pilot study	14
Reliable in-house LC-MS/MS method for steroid hormone analysis: Validations and comparisons	14
W226 NGS-based pipeline for routine non-invasive preimplantation genetic assessment in IVF	14
M122 Sample rejection of mixed body fluids for CSF identification – The utility of fluid protein concentration	14
Analysis of two intestinal bacterial metabolites (trimethylamine N-oxide and phenylacetylglutamine) in human serum samples of patients with T2DM and AMI using a liquid chromatography tandem mass spect	14
Association of metabolic and lipid indices with severity among patients with acute pancreatitis: A 10-year prospective registry-based cohort study with focus on hypertriglyceridemia-associated acute p	14
Electrochemical biosensors in early leukemia detection	14
Non-invasive fetal RHD genotyping in d- (RH:-1) patients with RHD genomic sequences: retrospective study over 11 years	14
The clinical validation of a dried blood spot method for simultaneous measurement of cyclosporine A, tacrolimus, creatinine, and hematocrit	14
Clinical and genetic investigation in patients with permanent congenital hypothyroidism	14
Analysis of gene mutation characteristics and its correlation with prognosis in patients with myelodysplastic syndromes	14
Sclerostin in ankylosing spondylitis: A meta-analysis	14
Relationships among maternal monosomy X mosaicism, maternal trisomy, and discordant sex chromosome aneuploidies	14
Metabolomic profiling of serum and tongue coating of pregnant women with intrahepatic cholestasis in pregnancy	14
Clinical implications of opioid parent-metabolite ratios	14
Overweight and obesity: The weight of genes	14
Evaluation of the performance of biochemical ratios and albumin’s gradient in the etiological exploration of ascitic fluid	13
Serologic profile of individuals who contracted COVID-19 despite triple vaccination	13
Clinical performance evaluation of smartchek SARS-COV-2 detection kit and smartchek SARS-COV-2 fast detection kit for detection of severe acute respiratory syndrome coronavirus 2 (SARS-COV-2) in saliv	13
Performance verification and reference interval establishment of serum/plasma aldosterone by a novel “sandwich” chemiluminescent immunoassay	13
Brucella outbreak linked to ice cream: A Lebanese case series	13
Leveraging machine learning to improve current diagnostic algorithms and laboratory stewardship	13
Mild-to-moderate COVID-19 may affect nervous system function in convalescents	13
Utility of serum indices for predicting liver fibrosis	13
Study of teratozoospermia in our population through analysis of seminal fluid in the assisted human reproduction unit of a Spanish referral hospital	13
Impact of CSF collection volume in the accuracy of Alzheimer’s disease biomarker results	13
Revolutionizing cell-based analyses: An electrochemical analysis platform with integrated incubator capabilities	13
Waste management in clinical laboratories	13
Distance changes of lymphocyte quantity and function in patients with COVID-19	13
The association of siMS and siMS risk scores with risk factors for cardiovascular events in university students with metabolic syndrome	13
The role of laboratory diagnostics in determining the physical health of psychiatric inpatients	13
Enhancing enteric pathogen detection: implementation and impact of multiplex PCR for improved diagnosis and surveillance	13
Apolipoprotein C-III mucin core 2 O-Linked glycoforms: Hiding in plain sight	13
Strategic collaboration to address nitrous oxide challenges: Establishment of an international consortium of experts	13
Association of HIV-1 Nef polymorphisms with coronary artery disease in HIV-positive patients	13
Novel biomarkers to improve diagnosis and monitor prognosis	13
Liaison MeMed BV: A new approach for a quicker diagnosis between viral and bacterial infections in a cohort of pediatric patients	13
Neonatal myofibrillar myopathy type II associated with biallelic UNC-45B gene novel mutation and perinatal myasthenia as the core phenotype: A case report	12
At-admission HbA1c levels in hospitalized COVID-19 participants with and without known diabetes	12
Challenges with sweat testing – A quality improvement initiative	12
Limitations of hemolysis-based correction for potassium measurement in hemolyzed whole blood samples	12
Pediatric reference values of NT-proBNP and Galectin-3 based on a French cohort	12
Study of the impact of ClinGen Revisions on ACMG/AMP variant semi-automatic classification for Rare Diseases diagnosis	12
The role of tubulointerstitial markers in differential diagnosis and prognosis in patients with type 2 diabetes and biopsy proven diabetic kidney disease	12
The assessment of endocannabinoids and N-acylethanolamines in human hair: Associations with sociodemographic and psychological variables	12
Corrigendum to “The impact of triadimenol on male fertility: An in vitro study and molecular docking examination” [Reprod. Toxicol. 132 (2025) 108861]	12
Exploring the key factors of schizophrenia relapse by integrating LC-MS/1H NMR metabolomics and weighted correlation network analysis	12
A novel variant of the POLR3A gene in a patient with hypomyelinating POLR3-related leukodystrophy	12
Fragmentation of human cardiac troponin T after acute myocardial infarction	12
The association between the PON1 genes rs662 and rs854560 and the metabolic syndrome in patients with obesity	12
A novel KCNQ2 missense variant in non-syndromic intellectual disability causes mild gain-of-function of Kv7.2 channel	12
Association between apolipoprotein B/A1 and the risk of metabolic dysfunction associated fatty liver disease according to different lipid profiles in a Chinese population: A cross-sectional study	12
Evaluating the efficacy of a long-read sequencing-based approach in the clinical diagnosis of neonatal congenital adrenocortical hyperplasia	12
HDL subfractions determined by microfluidic chip electrophoresis predict the vulnerability of intracranial plaque: A HRMRI study	12
Integration of coagulation parameters Enhances deep Learning-Based survival prediction in High-Grade serous ovarian Cancer: A comprehensive prognostic model	12
Estimation of FGF-23 level in patients with chronic kidney disease with or without vitamin D supplementation	12
A CD3G homozygous pathogenic variant in a Chinese child with lupus-like disease, autoimmune thyroiditis and immunodeficiency	12
Validation of a liquid chromatography coupled to tandem mass spectrometry method for simultaneous quantification of tryptophan and 10 key metabolites of the kynurenine pathway in plasma and urine: App	12
Evaluation of an enzymatic one-step assay for Beta-Hydroxybutyrate blood testing on clinical chemistry platforms using HILIC-MS/MS as a non-enzymatic reference method	12
Associations between polycythemia and cardiometabolic risk factors in middle-aged men	12
Artificial intelligence in the clinical laboratory	12
Evaluating data accuracy in clinical laboratory requests: A therapeutic drug monitoring study	11
Autologous platelet-rich plasma as adjuvant treatment in patients with refractory endometrial growth: Preliminary results from a 2-year prospective study in a Spanish reference unit of assisted human	11
An adult patient with Tatton-Brown-Rahman Syndrome: case report and novel DNMT3A variant not previously reported	11
Dihydropyrimidine dehydrogenase phenotyping by LC-MS/MS determination of uracil in human plasma	11
Assessment of a novel point-of-care system for chemistry panel testing	11
Indisputable vs. questionable actionable secondary findings in a cohort of 500 Lebanese participants: What to report to the patient?	11
Stabilization of glucose concentration in the new vacuette® FC mix blood collection tube for diagnosis of diabetes and gestational diabetes	11
Deciphering biological impact of nitrous oxide abuse: Insights from targeted metabolomics analysis	11