Clinica Chimica Acta

Papers
(The TQCC of Clinica Chimica Acta is 1. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-02-01 to 2025-02-01.)
ArticleCitations
External quality assessment for molecular detection of Ureaplasma urealyticum in China156
Epigenetics of Diabetes: A bioinformatic approach106
Evaluation of thrombin generation assay in factor XI deficiency101
Monocyte distribution width and the fighting action to neutralize sepsis (FANS) score for sepsis prediction in emergency department78
MicroRNA biosensors for detection of glioblastoma74
A large cohort of Hb H disease in northeast Thailand: A molecular revisited, diverse genetic interactions and identification of a novel mutation73
A comprehensive molecular approach in fish allergy: Usefulness in daily clinical practice69
Omentin-1: Protective impact on ischemic stroke via ameliorating atherosclerosis64
Associations of glycated albumin and fructosamine with glycaemic status in urban black South Africans62
Reference intervals for plasma vitamin B12 and plasma/serum methylmalonic acid in Danish children, adults and elderly60
Comparative study of droplet-digital PCR and absolute Q digital PCR for ctDNA detection in early-stage breast cancer patients57
Presence of anti-gp210 or anti-sp100 antibodies in AMA-positive patients may help support a diagnosis of primary biliary cholangitis56
Value of urine/serum Neutrophil gelatinase-associated lipocalin ratio in distinguishing acute kidney injury from chronic kidney disease55
SLC37A4-CDG: New biochemical insights for an emerging congenital disorder of glycosylation with major coagulopathy52
Emerging role of serum dickkopf-1 in prognosis of aneurysmal subarachnoid hemorrhage47
Next-generation reference interval for total IgE in the United States: A retrospective real-world analysis46
Crescent calculator: A webtool enabling objective decision-making for assessment of IgA nephropathy immune activity throughout the disease course46
Functions of nuclear receptors SUMOylation43
Exploration and time-serial validation of logistic regression models composed of multiple laboratory tests for early detection of HCV-associated hepatocellular carcinoma42
Irisin in atherosclerosis42
Targeted next-generation sequencing reveals novel and known variants of thrombophilia associated genes in Saudi patients with venous thromboembolism40
Effects of blood-processing protocols on cell-free DNA fragmentomics in plasma: Comparisons of one- and two-step centrifugations39
Quantification of choline in serum and plasma using a clinical nuclear magnetic resonance analyzer39
Polymyositis and dermatomyositis biomarkers38
Biological variation of cardiovascular biochemical markers in patients with Type 2 Diabetes Mellitus37
Extracellular vesicle-transferred long noncoding RNAs in bladder cancer36
Circulating microparticles as indicators of cardiometabolic risk in PCOS35
Application of chemoresistive gas sensors and chemometric analysis to differentiate the fingerprints of global volatile organic compounds from diseases. Preliminary results of COPD, lung cancer and br35
Reference interval establishment and correlation research of urine thromboxane metabolites: Unveiling new possibilities in platelet activation34
Circulating HPV DNA in HPV-associated cancers34
Hook-effect in MAGLUMI immunoassay for serum anti-GAD antibodies in neurological disorders: When “wrong” matrix is the right choice34
Detection of mutation profiles and tumor mutation burden of cerebrospinal fluid circulating DNA by a cancer genomic panel sequencing in glioma patients34
Editorial Board34
Genetic architecture of preeclampsia34
Comparative study of plasma clearance of iohexol at different injection doses34
Diagnostic potential of vitreoretinal lymphoma by detection of gene mutations with NGS in 25 Chinese patients33
Delta check limits for thyroid function tests adjusted for clinical settings32
“Tranq-dope”: The first fatal intoxication due to xylazine-adulterated heroin in Italy31
An atypical finding on serum immunofixation in free light chain multiple myeloma: A case report29
First case of 5-oxoprolinuria with two homozygous mutations in GSS and OPLAH genes: A case with neonatal presentation and rapid fatal outcome29
Changes in plasma level of endocrine hormones in lepromatous leprosy patients29
MMP-26 potential utility as a marker for differentiating serous ovarian cancer from serous cystadenomas28
Pre-analytical issues in haemostasis28
Does long term PPI use cause vitamin B12 deficiency ?28
Quantification of serum gp210 and sp100 antibodies in diagnosis of primary biliary cholangitis28
“Revolutionizing emergency care: A comparative analysis of comprehensive point-of-care test panels vs conventional laboratory processes in the critical care& emergency medicine”27
Carbapenem-resistant Enterobacteria at the hospital of Monastir27
Adoption and barriers to participation in a comparison program of core laboratory quality indicators among hospitals in Toronto, Canada26
In-vitro and in-vivo studies of M. oliefera derived compounds as a promising therapeutic target in breast cancer progression and metastasis26
Cell-free DNA bearing p53 mutation (R248) as non-invasive biomarker in patients with head and neck squamous cell carcinoma26
Using big data analytics to measure the multi-year consistency of sigma metrics for vitros cardiac assays26
Assessment of serum osteopontin, osteoprotegerin and bone-specific alp as markers of bone turnover in patients with disorders of thyroid function in Ile-Ife, Nigeria25
Impact of laboratory accreditation on the performance of quality indicators in an international indicator benchmarking program25
Implementation of first coagulation total laboratory automation system in Taiwan – An experience from a 3000-beds medical center25
Association of single nucleotide polymorphisms in eNOS gene with development of diabetic nephropathy: A case control study24
Overweight and insulin resistance in Algerian adolescent24
Calculated LDL cholesterol (freidwald, martin johns and Sampson) comparison of retrospective data with direct LDL cholesterol and hypertriglyceridaemia24
Total lab automation validation/verification: First step of process excellence journey in smart core lab24
Evaluation of the current status of the vitamin D assay standardization in China23
Novel prediction model of early screening lung adenocarcinoma with pulmonary fibrosis based on haematological index23
Unveiling liquid markers: The diagnostic revolution in early detection of pancreatic cancer through liquid biopsy23
Availability of ionized magnesium active form depends on kidney function and albumin levels23
Performance of laboratory services and systems in laboratory of a hospital in Nepal23
The connection of Vitamin D concentration with hematological parameters in patients with COVID-1922
Platelet volume indices and their association with atherogenic index of plasma in type 2 diabetes mellitus patients22
Advanced oxidation protein products and catalase activity in patients with psoriasis22
Diagnostic pitfalls in ANCA testing by ANA patterns and titers22
Antibiotic resistance profile of enterobacteriaceae isolated from infected hemodialysis catheters22
Transferability and degree of harmonization of an LC-MS based reference measurement procedure for apolipoproteins in a network of calibration laboratories22
Changes in nonalcoholic fatty liver disease and M2BPHI due to lifestyle intervention in primary healthcare21
Can lipid mediators be useful biomarkers in schizophrenia?21
Plasma 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D levels in breast cancer risk in Mali: A case–control study21
Review on the most important methylated genes in circulatory tumor DNA of brain tumor patients: Novel horizon towards early diagnosis and therapeutic follow up21
Evaluation of interleukin-4, micro-albumin, and creatinine in students exposed to short-term formal in Nnewi21
Performance of laboratory services and systems in laboratory of a hospital in Nepal21
Differentiation of HbD and HbG-philadelphia by HbA concentration during neonatal screening20
Evaluation OF FGF-23 as a marker of mineral bone disease among newly diagnosed chronic kidney disease patients in a Nigerian hospital20
Failure to diagnose factor X deficiency in patient treated with anticoagulant therapy: A fatal case20
Exploring artificial intelligence techniques for morphological analysis of digital images of peripheral blood cells: MC-80 versus HemaVision20
Treating red blood cells with dithiothreitol can help eliminate daratumumab interference in blood compatibility tests (pretransfusion testing)20
Faecal calprotectin as a potential biochemical marker of ulcerative colitis activity stratification20
Accurate correction model of blood potassium concentration in hemolytic specimens19
The biochemical and cytological examination of the cerebrospinal fluid (CSF) and the number of erythrocytes19
Beyond direct methods: Establishing vitamin d reference intervals using real-world data19
Possibility of using erythrocyte indexes to predict clinical outcome in patients with burn injury19
Raman spectroscopic analysis of urine combined with machine learning identifies life-threatening inborn errors of metabolism19
Association between serum lipid profile and clinicopathological features in breast cancer patients19
The influence of thyroid autoantibodies on depression severity19
Serum adenosine deaminase as breast and colorectal cancer progression biomarker19
Evaluation of the management of infectious risk at the laboratories of the Yaounde University Teaching Hospital19
Detection of hotspot PIK3CA mutations in primary tumors and plasma-cfDNA of breast cancer patients using a novel highly sensitive CE-IVD KIT19
Earthquakes, wars and emerging infectious disease18
Cardiorenal syndrome and diabetes mellitus in indonesian population18
Anti-diabetic and anti-inflammatory properties of some selected plant leaves: A transcriptomic approach18
Evaluation of phosphocalcic metabolism and vitamin d status in renal transplant patients at military hospital of Oran, Algeria17
Verification of equimolar peptide release in a mass spectrometry-based reference measurement procedure for quantification of Apolipoprotein(A)17
Investigating the long-term effects of lung-specific autoantibodies post-COVID-19 following thoracic surgery17
Myo-inositol: A novel biomarker for kidney disease17
Mid-Regional proadrenomedullin (MR-PROADM) may be a new marker of severity status of patient with systemic inflammatory response-pilot project17
Hemolysis index measured on Cobas Pro is a good surrogate to plasmatic hemoglobin measurement in clinical pratice17
An estimation of fructosamine threshold values for the diagnosis of diabetes in a Tunisian population17
Viscoelastic blood tests use in adult cardiac surgery17
Heavy-light chain pairs as an alternative method to monitor isatuximab-based treatment responses in multiple myeloma patients17
Escherichia coli nissle (E.COLI NISSLE) modulated in colon cancer therapy16
Effects of vitamin D supplementation in neonates and infant16
Stability of arterial and venous gas samples stored for 20, 40 and 60 minutes after collection16
The essential role of volunteer biologists in Lebanon’s COVID-19 pandemic management efforts16
The relationship between disorders of the plasma and platelet components of hemostasis with the severity and timing of coronavirus infection in patients with chronic coronary syndromes16
COVID-19 infection: a review of hematological and morphological features16
The management of heart failure patients in a value-based healthcare system: The role of cardiac biomarkers16
Follow-up of the TG and ANTI-TG in patient with differentiated thyroid cancer by two different analytical methods16
Strategy to improve the turn around time (TAT) for stat samples in clinical laboratories16
Results of 2023 national external quality assessment of hemostasis testing in medical laboratories of the Republic of Belarus16
Comparison of demographical features and chemical composition in patients with renal stones in a tertiary care center16
The role of unsaturated iron binding capacity (UIBC) in the diagnosis of anemia15
Large-scale analysis reveals splicing biomarkers for tuberculosis progression and prognosis15
Fcm in characterizing acute leukemic disorders15
Imiquimod-loaded chitosan-decorated di-block and tri-block polymeric nanoparticles gel for the management of human cervical intraepithelial neoplasia15
Management of discrepancies between immunocap specific IgE and the two multiplex test platforms immunocap ISAC and MADx ALEX 2 in a pediatric patient with anaphylaxis15
Extensive molecular heterogeneity and transcriptomic signatures of circulating tumour cells are potential predictors of oral squamous cell carcinoma15
Validating urinary orotic acid through high-pressure liquid chromatography (HPLC): Insights from a specialized biochemical genetics laboratory in Pakistan15
Serum concentration of asymmetrical dimethylarginine and protein carbonyl in patients with cardiovascular diseases15
Plasma levels of matrix metalloproteinases in patients with breast cancer as a potential marker of cardiotoxicity associated with doxorubicin therapy15
Laboratory indicators of inflammation in the development of cytokine storm in patients with COVID-1914
Clinical significance of medical leadership and laboratory management: Challenges and perspectives14
Unmanned high speed aerial vehicles in medical logistics: A comparative analysis of blood sample transportation with weather variability14
Real-world data shows the effectiveness of a tetravalent vaccine against human papilloma virus types 16 and 18 in Chilean women14
Electrophoretic profiles of patients with different types of hemoglobinopathies in south Tunisia14
Exploring the relationship between Oxysperm and Sperm DNA Fragmentation Index (DFI) in the context of fertility potential14
Stiff person syndrome (SPR): A case report14
Data science, digital health, big data and smart technologies to support biotechnology – Current perspectives and future challenges14
Profile of soluble MER (sMER) and ADAM17 in relation to waist circumference range: Analyzing efferocytosis signaling in men with central obesity14
Rotational thromboelastometry (CLORPRO) profiling of COVID-19 patients14
The importance of determining hepcidines and soluble transferrin receptor (STFR) in haemodialysis patients14
Clinical validation in multiple sclerosis of the lumipulse immunoassay for plasma neurofilament light chain13
Evaluation of beta glucan test using kinetic turbidimetric method on toxinometer MT-6500 for detection of invasive fungal infections in hospitalized patients13
The increased sensitivity of the Xpert® Xpress assay in detecting SARS-COV-2, compared to the COBAS® assay, can be attributed to the nucleocapsid gene target13
Indeterminate results in quantiferon-TB gold plus testing: Possible explanation and predictive parameters13
Frequency of occurrence of zoonotic tick-borne pathogens in ticks – Latvian 2023 year experience13
Molecular characterization of vibrio parahaemolyticus isolated from coastal environment in Eastern Province of Saudi Arabia13
Evaluation of pre-analytical quality indicators by six sigma principle: Experience at a tertiary care hospital13
Biological investigation of oxalocalcic lithiasis: Contribution of morphoconstitutional analysis and metabolic assessment13
Evaluation of the diagnostic efficacy of hepatitis C virus infection in our healthcare area13
Circulating miRNAs associated with physical performance in elderly subjects13
Quantitative stool culture in hospitalized neonates: Microbiological analysis, antibiotic resistance patterns, and clinical management implications13
Interference of hemolysis in urgent clinical biochemistry examinations analyzed on DxC 700 AU and access 213
A study of c-reactive protein in breast cancer: Risk factor and prognostic13
Determination of direct oral anticoagulant in the emergency laboratory: The experience in pandemic and post-pandemic period13
Laboratory-based study of newborn with intrauterine growth restriction13
Diabetes related foot infections: Bacterial epidemiology and antibiotic susceptibility profiling13
Escherichia coli in urine: Sensitivity to first-line molecules13
Blood donation and hepatitis seroprevalence transfusion medicine: A solution or a risk in a Palestinian perspective12
Still’s syndrome. A case study12
Isolation, cloning, and sequencing the codiaeum variegatum GAPC gene12
Principle of flow cytometry and issues in diagnosis12
Using a diagnostic panel to determine predisposition to the development of disorders of the thyroid system12
A variant reclassification of SLC12A3 of Gitelman syndrome12
Association of single nucleotide polymorphism of KCNJ11 (rs 5219) with type 2 diabetes mellitus in north Indian population12
Six sigma improves the performance of quality control, financial and operation efficiency in a nationwide laboratory network in Mexico12
Interference in the determination of glycosylated hemoglobin caused by a hemoglobonipathy: A case report12
Le Mans Protocol – Evidence-based approach to proof your choice of production concept12
Enhancing the sensitivity of rapid antigen detection test (RADT) of different SARS-COV-2 variants and lineages using fluorescence-labeled antibodies and a fluorescent meter12
The technology for clinical laboratories in 21st century: Challenges and opportunitie11
Machine learning-based prediction of intensive care during hospitalization for COVID-19 using laboratory test results at admission11
Biomarker panels: Analytical and clinical validation against clinically relevant reference standards11
Intake of selected fat-soluble vitamins and trace elements on selected parameters of skin condition11
Uric acid lithiasis in southern Tunisia11
Testosterone II (TSTII) and dimension VISTA® LOCI total testosterone (TTST) immunoassays meet the CDC host certification requirements for more than four years11
Creating hemolysates using whole blood, are EDTA tubes the right choice?11
Assessment of vitamin D intake and supplementation in non-dialysis chronic kidney disease patients11
Next step in predictive medicine: New serum biomarkers to predict acute stroke mortality11
Incidental diagnosis of aneuploidy of the sex chromosomes in a neuropaediatric patient11
About a case “a precocious puberty in A 10-month-old infant”11
Assessment of MSTN and CYP2D6 polymorphisms and physical performance in a population of athletes from Western Mexico11
Atherogenic indices among women with benign and malignant breast lesions in Ile-Ife, Nigeria11
Prevalence of serum CEA and CA 19-9 elevation in patients with colorectal cancers at The Nairobi Hospital, Kenya11
Identification of immunoreactive COVID-19 epitopes based on M13 phage display library11
Unraveling mechanisms regulating erythroid iron metabolism11
Effect of cucumber supplementation on blood pressure, plasma lipid profile and some apolipoproteins in older adults in Nnewi, Nigeria11
The reality of antimicrobial resistance (AMR) in Palestine and its impact on health and economy: A cross-sectional study in West Bank, Palestine11
Acarbose a promising inhibitor of 17®-hydroxysteroid dehydrogenase type 1 as a potential candidate for anticancer therapy11
Sickle cell crisis vs thrombotic microangiopathy secondary to neoplastic process: The clinical laboratory in differential diagnosis11
Genotypic characterization of autosomal dominant polycystic kidney disease (ADPKD) in Indian population: A pilot study11
Apolipoprotein B and its correlation with dyslipidemia in Type 2 Diabetes Mellitus11
Effect of Candida auris secretions on monocyte-derived macrophages11
N-Terminal pro-b-type natriuretic peptide, iron status and red cell distribution width in suspected heart failure patients11
Antibiotic susceptibility of bacteria isolated in pediatric settings during bacteremia11
Why do scientists call for action against vitamin D deficiency and what is behind the scene?11
HDL functionality assessments and its relevance to the cardiovascular endpoints; Mashad cohort study over 10 years11
Detection of mycobacterium tuberculosis and rifampicin resistance with Xpert® MTB/RIF analysis in a tertiary hospital11
Path to lab accreditation and improvements11
Green laboratory medicine in Africa: What is the contribution to environmental toxicity and how prepared is the continent for sustainable laboratory medicine?10
Risk assessment for patient by centrifugation of samples on the DxA 5000 fit Beckman Coulter automated system10
Serum anti-oxLDL antibodies in patients with angiographically confirmed coronary artery disease10
Effect of bilirubin assays on treatment decision in neonatal jaundice: Past and present using Dutch external quality assessment results10
The pentraxin family in autoimmune disease10
FIB-4 index: The importance of including pyridoxal-5-phosphate in alt and AST methods10
Effects of obesity on liver function in children10
Complete blood count parameters in CKD patients compared to healthy subjects10
Analysis of thicknesses of blood collection needle by scanning electron microscopy reveals wide heterogeneity10
Profiling of circulating-MicroRNAs’ signatures in pre-diabetic versus diabetic patients10
Superfluous amylase and lipase testing10
A diagnostic dilemma of TSHoma in a clinically euthyroid patient10
Exploring optimization algorithms for establishing patient-based real-time quality control models10
Non-coding RNAs as biomarkers of myocardial infarction10
Editorial Board10
Prediction of atherosclerosis in severe COVID-19 patients with CD16 and CD18 markers and inflammatory factors10
Seroprevalence and risk factors of toxoplasmosis among pregnant women in the M’saken region (Tunisia)10
The clinical value of artificial intelligence in laboratory medicine10
Laboratory evaluation of RBC transfusion in patients with coronary artery disease10
Plasma oxidative lipidomics reveals signatures for sepsis-associated acute kidney injury10
Altered bile metabolome and its diagnostic potential for biliopancreatic malignancies10
A haemochromatosis-causing HFE mutation is associated with SARS-CoV-2 susceptibility in the Czech population10
Role of apolipoproteins in the pathogenesis of obesity9
A rapid multiplex assay of human malaria parasites by digital PCR9
Resistin and omentin in breast cancer: A systematic review and meta-analysis9
Additive value of bioclinical risk scores to high sensitivity troponins-only strategy in acute coronary syndrome9
Identification of the first Alu-mediated gross deletion involving the BCKDHA gene in a compound heterozygous patient with maple syrup urine disease9
Comparison of digital PCR systems for the analysis of liquid biopsy samples of patients affected by lung and colorectal cancer9
The early effects of sleeve gastrectomy on postprandial chylomicron triglycerides during the progression of type 2 diabetes9
Association of serum anti-carbamylated protein antibodies with disease activity and bone loss in rheumatoid arthritis9
UHPLC-MS/MS-based untargeted lipidomics analysis of septic patients9
Evaluating the effect of gestational diabetes mellitus on macrosomia based on the characteristics of oral glucose tolerance test9
Functional characterization of novel variants found in patients with suspected Fabry disease9
Phosphatidylethanol in patients with liver diseases of different etiologies: Analysis of six homologues and comparison with other alcohol markers9
Advances in the identification of calcium carbonate urinary crystals9
Serum metabolomics study of anxiety disorder patients based on LC-MS9
Exploring the effect of APOE ε4 on biomarkers of neurodegeneration in Alzheimer’s disease9
Serum Gas6 contributes to clinical outcome after aneurysmal subarachnoid hemorrhage: A prospective cohort study9
Measuring steroids from dried blood spots using tandem mass spectrometry to diagnose congenital adrenal hyperplasia9
High CDT without clinical context: Beware of the variant9
M155 Urinary VMA, HVA and 5-HIAA measurement on HPLC with electrochemical detection – A 3-way method comparison study using commercially available reagents9
Biomarkers of endometriosis9
The clinical value of rapidly detecting urinary exosomal lncRNA RMRP in bladder cancer with an RT-RAA-CRISPR/Cas12a method9
Circulating calprotectin as biomarker in neutrophil-related inflammation: Pre-analytical recommendations and reference values according to sample type9
Hypomethylation of RPTOR in peripheral blood is associated with very early-stage lung cancer9
P-tau217 in Alzheimer’s disease9
Kappa free light chains: Diagnostic performance in multiple sclerosis and utility in a clinical laboratory9
Seeking consistency for the role of urinary macromolecules and glycosaminoglycans in calcium oxalate crystallization processes pertaining to the risk of renal stone formation using a multi-faceted bas9
Clot waveform analysis for perioperative hemostatic monitoring in a hemophilia A patient on emicizumab undergoing liver transplantation9
Biological variation of thyroid function biomarkers over 24 hours9
Monitoring mutant KRAS in plasma cell-free DNA can predict disease progression in a patient with multiple myeloma: A case report8
Analysis of the diagnostic and prognostic value of serum PAD2 in patients with sepsis in the intensive care unit8
M208 Pakistan inherited metabolic disorders network (PAK-IMD-NET): Breaking silos and bringing synergies8
Cerebrospinal fluid protein biomarkers in Parkinson's disease8
The role of serum free light chain as biomarker of Myasthenia Gravis8
Atopic respiratory diseases and IgE sensitization are associated with leukocyte subset concentrations in 14,440 blood donors8
Detection of pathogens from venous or arterial blood of patients with left-sided infective endocarditis by metagenomic next-generation sequencing: A prospective study8
High-throughput omics technologies in inflammatory bowel disease8
M212 Molecular &; biochemical investigations of inborn errors of metabolism & altered redox homeostasis – An underrecognised cause with emerging importance8
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