Clinica Chimica Acta

Article	Citations
Dopamine in Parkinson's disease	142
Laboratory findings in COVID-19 diagnosis and prognosis	141
Declined serum high density lipoprotein cholesterol is associated with the severity of COVID-19 infection	130
Pyroptosis: A pro-inflammatory type of cell death in cardiovascular disease	112
Laboratory diagnosis of coronavirus disease-2019 (COVID-19)	100
circRNA-miRNA-mRNA in breast cancer	100
Circulating microRNAs: Biomarkers of disease	92
Antibody response to first and second dose of BNT162b2 in a cohort of characterized healthcare workers	74
The PrecivityAD™ test: Accurate and reliable LC-MS/MS assays for quantifying plasma amyloid beta 40 and 42 and apolipoprotein E proteotype for the assessment of brain amyloidosis	73
Calprotectin in inflammatory bowel disease	70
Droplet digital PCR as an emerging tool in detecting pathogens nucleic acids in infectious diseases	69
rRT-PCR for SARS-CoV-2: Analytical considerations	64
Salivary SARS-CoV-2 antigen rapid detection: A prospective cohort study	60
Mitochondrial iron metabolism and its role in diseases	60
ICAM-1 and VCAM-1: Gatekeepers in various inflammatory and cardiovascular disorders	59
SARS-CoV-2 identification and IgA antibodies in saliva: One sample two tests approach for diagnosis	58
Cardiac biomarkers of heart failure in chronic kidney disease	58
ACE deletion allele is associated with susceptibility to SARS-CoV-2 infection and mortality rate: An epidemiological study in the Asian population	57
Exhaled breath analysis in disease detection	55
Hyperlipidemia and hypothyroidism	52
Angiotensin converting enzyme (ACE)	48
COVID-19: Review and hematologic impact	48
Pyroptosis in diabetic nephropathy	46
Neutrophil gelatinase-associated lipocalin (NGAL) in kidney injury – A systematic review	44
Detection of COPD and Lung Cancer with electronic nose using ensemble learning methods	44

Evaluation of Abbott anti-SARS-CoV-2 CMIA IgG and Euroimmun ELISA IgG/IgA assays in a clinical lab	44
Advances in lipidomics	44
Immune regulation in polycystic ovary syndrome	42
Resistin: Potential biomarker and therapeutic target in atherosclerosis	42
Traditional and modern management strategies for rheumatoid arthritis	42
Revealing the role of glycerophospholipid metabolism in asthma through plasma lipidomics	42
Lipid metabolism changes in patients with severe COVID-19	42
Comparison of test performance of commercial anti-SARS-CoV-2 immunoassays in serum and plasma samples	40
Small dense low-density lipoprotein: Analytical review	39
The red blood cell distribution width-albumin ratio: A promising predictor of mortality in heart failure patients — A cohort study	38
The ABCA1-efferocytosis axis: A new strategy to protect against atherosclerosis	38
Oxidative stress in vascular calcification	37
Standardization process of continuous glucose monitoring: Traceability and performance	37
Prognostic value of changes in neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR) and lymphocyte-to-monocyte ratio (LMR) for patients with cervical cancer undergoing definitive c	37
The circadian clock and inflammation: A new insight	36
The diagnostic value of serum C-reactive protein, procalcitonin, interleukin-6 and lactate dehydrogenase in patients with severe acute pancreatitis	36
Potentiometric urea biosensors	35
Elevated systemic immune inflammation index level is associated with disease activity in ulcerative colitis patients	35
MicroRNA in multiple sclerosis	35
The trends in nanomaterial-based biosensors for detecting critical biomarkers in stroke	34
IgG antibodies against SARS-CoV-2 decay but persist 4 months after vaccination in a cohort of healthcare workers	34
Recommendations on the measurement and the clinical use of vitamin D metabolites and vitamin D binding protein – A position paper from the IFCC Committee on bone metabolism	34
ACE I/D polymorphism in Czech first-wave SARS-CoV-2-positive survivors	34
Potential diagnostics and therapeutic approaches in COVID-19	34
Analytical considerations and plans to standardize or harmonize assays for the reference bone turnover markers PINP and β-CTX in blood	34
The role of TPS, CA125, CA15-3 and CEA in prediction of distant metastasis of breast cancer	33
Mechanisms of cancer stem cell therapy	32
Comparison of qualitative and quantitative analyses of COVID-19 clinical samples	32
Biosensors in Parkinson’s disease	31
Iron metabolism and the exocrine pancreas	31
Comparison of reference intervals derived by direct and indirect methods based on compatible datasets obtained in Turkey	31
The diagnostic and prognostic role of myocardial injury biomarkers in hospitalized patients with COVID-19	30
Chemerin in inflammatory diseases	30
The DNA replication regulator MCM6: An emerging cancer biomarker and target	29
Lactic acid in tumor invasion	29
Reference interval of monocyte distribution width (MDW) in healthy blood donors	29
Advances in drugs of abuse testing	29
Antibodies against severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) in individuals with and without COVID-19 vaccination: A method comparison of two different commercially available s	29
Albumin corrected anion gap for predicting in-hospital mortality among intensive care patients with sepsis: A retrospective propensity score matching analysis	29
Harmonization of six quantitative SARS-CoV-2 serological assays using sera of vaccinated subjects	28
Surface plasmon resonance: A promising approach for label-free early cancer diagnosis	28
Epigenetic factors in atherosclerosis: DNA methylation, folic acid metabolism, and intestinal microbiota	28
Ceramides improve atherosclerotic cardiovascular disease risk assessment beyond standard risk factors	28
Clinical laboratory evaluation of COVID-19	28
Development and performance of a next generation sequencing (NGS) assay for monitoring of mixed chimerism	28
Neutrophil extracellular traps and organ dysfunction in sepsis	28
Application of chemoresistive gas sensors and chemometric analysis to differentiate the fingerprints of global volatile organic compounds from diseases. Preliminary results of COPD, lung cancer and br	27
Identification of potential urine biomarkers in idiopathic parkinson's disease using NMR	27
NAD+ and cardiovascular diseases	26
Correlation of Krebs von den Lungen-6 and fibronectin with pulmonary fibrosis in coronavirus disease 2019	26

Update on serologic testing in COVID–19	26
Roles of MET in human cancer	26
Pyroptosis in diabetes and diabetic nephropathy	26
The S100 protein family in lung cancer	25
YKL-40 as a novel biomarker in cardio-metabolic disorders and inflammatory diseases	25
Assessment of patient-based real-time quality control algorithm performance on different types of analytical error	25
High prevalence of xylazine among fentanyl screen-positive urines from hospitalized patients, Philadelphia, 2021	25
The French paradox three decades later: Role of inflammation and thrombosis	24
Evaluation of the necessity and the feasibility of the standardization of procalcitonin measurements: Activities of IFCC WG-PCT with involvement of all stakeholders	24
Acute aluminum phosphide poisoning: The menace of phosphine exposure	24
Pathophysiology and immunogenetics of celiac disease	23
Insight into osteoarthritis through integrative analysis of metabolomics and transcriptomics	23
Non-transferrin bound iron	23
Sumoylation in liver disease	23
Necroptosis in atherosclerosis	23
Exosomal analysis: Advances in biosensor technology	23
What do we need to obtain high quality circulating tumor DNA (ctDNA) for routine diagnostic test in oncology? – Considerations on pre-analytical aspects by the IFCC workgroup cfDNA	23
Serum metabolite signatures of epithelial ovarian cancer based on targeted metabolomics	23
Endometrial cancer: A systematic review of HE4, REM and REM-B	22
Electrochemical prostate-specific antigen biosensors based on electroconductive nanomaterials and polymers	22
PLA2G10 incorporated in exosomes could be diagnostic and prognostic biomarker for non-small cell lung cancer	22
Circulating calprotectin as biomarker in neutrophil-related inflammation: Pre-analytical recommendations and reference values according to sample type	22
Comparison of two digital PCR methods for EGFR DNA and SARS-CoV-2 RNA quantification	22
Long non-coding RNA HCP5 in cancer	22
Diagnosing acute promyelocytic leukemia by using convolutional neural network	22
Exosomal noncoding RNAs in prostate cancer	22
LncRNAs in Osteoarthritis	22
COVID-19 infection and thrombosis	22
LC-MS/MS method for nine different antibiotics	22
Faecal immunochemical tests for haemoglobin: Analytical challenges and potential solutions	21
Plasma neurofilament light chain (NfL) reference interval determination in an Age-stratified cognitively unimpaired cohort	21
Role of Kruppel-like factor 4 in atherosclerosis	21
α-Synuclein in Parkinson's disease and advances in detection	21
Performance of an automated chemiluminescence SARS-CoV-2 IG-G assay	21
14-3-3 σ: A potential biomolecule for cancer therapy	21
ITIH4 is a novel serum biomarker for early gastric cancer diagnosis	21
The epitranscriptome of long noncoding RNAs in metabolic diseases	20
Omentin-1: Protective impact on ischemic stroke via ameliorating atherosclerosis	20
SARS-CoV-2 infection serology validation of different methods: Usefulness of IgA in the early phase of infection	20
Urinary podocyte markers in kidney diseases	20
Miniaturized Real-Time PCR systems for SARS-CoV-2 detection at the Point-of-Care	19
A machine learning model for the prediction of down syndrome in second trimester antenatal screening	19
Chemerin in atherosclerosis	19
Evaluation of interference from hemoglobin C, D, E and S traits on measurements of hemoglobin A1c by fifteen methods	19
CCR5 Δ32 minorallele is associated with susceptibility to SARS-CoV-2 infection and death: An epidemiological investigation	19
Near-infrared-based hematocrit prediction of dried blood spots: An in-depth evaluation	19
Assessment of tryptophan and kynurenine as prognostic markers in patients with SARS-CoV-2	19
Performance verification of five commercial RT-qPCR diagnostic kits for SARS-CoV-2	19
Hematocrit and standardization in DBS analysis: A practical approach for hormones mainly present in the plasma fraction	19
SARS-CoV-2 neutralizing antibodies after one or two doses of Comirnaty (BNT162b2, BioNTech/Pfizer): Kinetics and comparison with chemiluminescent assays	19
Recent advances in the regulation of ABCA1 and ABCG1 by lncRNAs	19
Cardiac troponin I in SARS-CoV-2-patients: The additional prognostic value of serial monitoring	19
Positive control synthesis method for COVID-19 diagnosis by one-step real-time RT-PCR	18
Hock-a-loogie saliva as a diagnostic specimen for SARS-CoV-2 by a PCR-based assay: A diagnostic validity study	18
Droplet digital PCR for large genomic rearrangements detection: A promising strategy in tissue BRCA1 testing	18
Digital PCR is a sensitive new technique for SARS-CoV-2 detection in clinical applications	18
Saliva for use with a point of care assay for the rapid diagnosis of COVID-19	18
Correlation between cytokines and coagulation-related parameters in patients with coronavirus disease 2019 admitted to ICU	18
Annexin A protein family in atherosclerosis	18
Single-cell sequencing technology in tumor research	18
Antioxidant nutrients and hemolysis in sickle cell disease	18
Advancing AI in healthcare: A comprehensive review of best practices	18
Lumican, pro-tumorigenic or anti-tumorigenic: A conundrum	18
Immunoglobulin G glycans – Biomarkers and molecular effectors of aging	17
Omics biomarkers for frailty in older adults	17
Reference intervals for plasma vitamin B12 and plasma/serum methylmalonic acid in Danish children, adults and elderly	17
Long-term decay of anti-RBD IgG titers after BNT162b2 vaccination is not mirrored by loss of neutralizing bioactivity against SARS-CoV-2	17
Evaluation of the clinical performance of single-, dual-, and triple-target SARS-CoV-2 RT-qPCR methods	17
Prenatal diagnosis and outcome of fetal hyperechogenic kidneys in the era of antenatal next-generation sequencing	17
Sphingosine-1-phosphate receptor 3 signaling	17
Positive association between systemic immune-inflammatory index and mortality of cardiogenic shock	17
A combined strategy of TK1, HE4 and CA125 shows better diagnostic performance than risk of ovarian malignancy algorithm (ROMA) in ovarian carcinoma	17
Pregnancy-specific reference intervals for C-reactive protein improve diagnostic accuracy for infection: A longitudinal study	17
Evaluation of volumetric blood collection devices for the measurement of phenylalanine and tyrosine to monitor patients with phenylketonuria	17
Estimation of low-density lipoprotein cholesterol by machine learning methods	17
Plasma metabolites, especially lipid metabolites, are altered in pregnant women with gestational diabetes mellitus	17
Quantifying apolipoprotein(a) in the era of proteoforms and precision medicine	17
CircRNAs in diabetic cardiomyopathy	17
Development, application, and evaluation of a problem-based learning method in clinical laboratory education	16
Prognostic efficacy of preoperative mGPS, SIS and LCS in patients with gastric cancer	16

Calculating estimated glomerular filtration rate without the race correction factor: Observations at a large academic medical system	16
GC-MS analysis of short chain fatty acids and branched chain amino acids in urine and faeces samples from newborns and lactating mothers	16
Ethical and organizational considerations for mandatory COVID-19 vaccination of health care workers: A clinical laboratorian's perspective	16
Circular RNAs in atherosclerosis	16
Multi-omics analysis of tumor mutation burden combined with immune infiltrates in melanoma	16
P-tau217 in Alzheimer’s disease	16
Biological evaluation of bone substitute	16
Development of a panel of autoantibody against NSG1 with CEA, CYFRA21-1, and SCC-Ag for the diagnosis of esophageal squamous cell carcinoma	16
Lipophagy in atherosclerosis	16
Quantification of choline in serum and plasma using a clinical nuclear magnetic resonance analyzer	16
Cell metabolic profiling of colorectal cancer via 1H NMR	15
Endothelial dysfunction and Mid-Regional proAdrenomedullin: What role in SARS-CoV-2 infected Patients?	15
Comparative analysis of chemical breath-prints through olfactory technology for the discrimination between SARS-CoV-2 infected patients and controls	15
Novel and recurrent variants identified in fetuses with central nervous system abnormalities by trios-medical exome sequencing	15
Evaluation of qSOFA combined with inflammatory mediators for diagnosing sepsis and predicting mortality among emergency department	15
Major depressive disorder: Biomarkers and biosensors	15
Differences of SARS-CoV-2 serological test performance between hospitalized and outpatient COVID-19 cases	15
Discovery of lipid profiles of type 2 diabetes associated with hyperlipidemia using untargeted UPLC Q-TOF/MS-based lipidomics approach	15
The evolving role of commutability in metrological traceability	15
A rapid and high-throughput Helicobacter pylori RPA-CRISPR/Cas12a-based nucleic acid detection system	15
Flow-based allergen testing: Can mast cells beat basophils?	15
Epigenetics of osteoarthritis: Histones and TGF-β1	15
Analytical validation of the droplet digital PCR assay for diagnosis of spinal muscular atrophy	15
Advances in the identification of calcium carbonate urinary crystals	14
Genosensors, a nanomaterial-based platform for microRNA-21 detection, non-invasive methods in early detection of cancer	14
Inborn errors of metabolism associated with 3-methylglutaconic aciduria	14
Anti-Ro52 antibody is highly prevalent and a marker of better prognosis in patients with ovarian cancer	14
Less expression of CD4+ and CD8+ T cells might reflect the severity of infection and predict worse prognosis in patients with COVID-19: Evidence from a pooled analysis	14
Transportation and handling of blood samples prior to ammonia measurement in the real life of a large university hospital	14
Liquid biopsy in ovarian cancer	14
Diagnostic and prognostic utility of presepsin for sepsis in very elderly patients in the emergency department	14
Serum biomarkers for liver fibrosis	14
Long noncoding RNA HOTAIRM1 in human cancers	14
Comparison of laboratory diagnosis, clinical manifestation, and management of pulmonary cryptococcosis: Report of the clinical scenario and literature review	14
A review: Pathological and molecular biological study on atherosclerosis	14
Supersensitive photon upconversion based immunoassay for detection of cardiac troponin I in human plasma	14
Serum metabolic profiling analysis of gout patients based on UPLC-Q-TOF/MS	14
Serum phospholipids are potential biomarkers for the early diagnosis of gastric cancer	14
Role of HAND2-AS1 in human tumors	14
Pathology of metabolically-related dyslipidemia	14
COVID-19 diagnostics: Molecular biology to nanomaterials	14
Tracking SARS-CoV-2 variants by entire S-gene analysis using long-range RT-PCR and Sanger sequencing	14
The N gene of SARS-CoV-2 was the main positive component in repositive samples from a cohort of COVID-19 patients in Wuhan, China	14
Preliminary reference intervals of Glycated Albumin in healthy Caucasian pregnant women	13
Serum sphingomyelin species profile is altered in hematologic malignancies	13
Combined metabolomics with transcriptomics reveals potential plasma biomarkers correlated with non-small-cell lung cancer proliferation through the Akt pathway	13
Biosensors technology for anti-epileptic drugs	13
Comprehensive analysis of protein-expression changes specific to immunoglobulin G4-related disease	13
The path to the standardization of PTH: Is this a realistic possibility? a position paper of the IFCC C-BM	13
A pregnancy-specific reference interval for procalcitonin	13
Caveolin-1 in autophagy: A potential therapeutic target in atherosclerosis	13
Stabilization of urinary biogenic amines measured in clinical chemistry laboratories	13
PIWI-interacting RNAs and PIWI proteins in diabetes and cardiovascular disease: Molecular pathogenesis and role as biomarkers	13
Non-coding RNAs as biomarkers of myocardial infarction	13
An intractable epilepsy phenotype of ASNS novel mutation in two patients with asparagine synthetase deficiency	13
The prostate health index (PHI) density: Are there advantages over PHI or over the prostate-specific antigen density?	13
Within-person biological variation estimates from the European Biological Variation Study (EuBIVAS) for serum potassium and creatinine used to obtain personalized reference intervals	13
Analysis of HOXA9 methylated ctDNA in ovarian cancer using sense-antisense measurement	13
Plasma lipid-based machine learning models provides a potential diagnostic tool for colorectal cancer patients	13
Establishing hemolysis and lipemia acceptance thresholds for clinical chemistry tests	13
Planning SQC strategies and adapting QC frequency for patient risk	13
Emerging roles of absent in melanoma 2 in cardiovascular diseases	13
Non-invasive diagnosis of endometriosis: Immunologic and genetic markers	12
Personalized reference intervals: Using estimates of within-subject or within-person biological variation requires different statistical approaches	12
An integrated pathological research for precise diagnosis of schizophrenia combining LC-MS/1H NMR metabolomics and transcriptomics	12
The apoM-S1P axis in hepatic diseases	12
Coronary artery disease and the risk-associated LPA variants, rs3798220 and rs10455872, in patients with suspected familial hypercholesterolaemia	12
Functions of nuclear receptors SUMOylation	12
Elevated soluble programmed death-ligand 1 levels indicate immunosuppression and poor prognosis in hepatocellular carcinoma patients undergoing transcatheter arterial chemoembolization	12
Uric acid metabolism in polycystic ovary syndrome	12
Comparison between thromboelastography and conventional coagulation assays in patients with deep vein thrombosis	12
Midkine: A multifaceted driver of atherosclerosis	12
The impact of neutrophil extracellular traps on deep venous thrombosis in patients with traumatic fractures	12
The inflammatory markers sST2, HSP27 and hsCRP as a prognostic biomarker panel in chronic heart failure patients	12
Plasma metabolic signatures for intracranial aneurysm and its rupture identified by pseudotargeted metabolomics	12
Serum level of testosterone predicts disease severity of male COVID-19 patients and is related to T-cell immune modulation by transcriptome analysis	12
Exosomes in HBV infection	12
Copeptin in fluid disorders and stress	12
Serum ceramide concentrations are associated with depression in patients after ischemic stroke-A two-center case-controlled study	12
Genistein upregulates cyclin D1 and CDK4 expression and promotes the proliferation of ovarian cancer OVCAR-5 cells	12
The diagnostic value of IL-10 and IL-6 level in vitreous fluid and aqueous humor for vitreoretinal lymphoma	11
Noninvasive fecal testing for colorectal cancer	11
Breath analysis using electronic nose and gas chromatography-mass spectrometry: A pilot study on bronchial infections in bronchiectasis	11
Implementing reference systems for thyroid function tests – A collaborative effort	11
GC-MS-based metabolomics reveals new biomarkers to assist the differentiation of prostate cancer and benign prostatic hyperplasia	11
Extracellular vesicle YRNA in atherosclerosis	11
A high-throughput assay for the quantification of intact Insulin-like Growth Factor I in human serum using online SPE-LC-HRMS	11
Comparison of digital PCR systems for the analysis of liquid biopsy samples of patients affected by lung and colorectal cancer	11
A novel 4.9 Kb deletion at beta-globin gene is identified by the third-generation sequencing: Case report from Baoan, China	11
Angiopoietin-like proteins in atherosclerosis	11
Big data and reference intervals	11
LDL-C/HDL-C ratio associated with carotid intima-media thickness and carotid plaques in male but not female patients with type 2 diabetes	11
Harmonization of two hs-cTnI methods based on recalibration of measured quality control and clinical samples	11
DLX6-AS1 is a potential biomarker and therapeutic target in cancer initiation and progression	11
Novel automated sample-to-result SARS-CoV-2 laboratory-developed RT-PCR assay for high-throughput testing using LabTurbo AIO 48 system	11