OOIR: Observatory of International Research

Papers

(The TQCC of Circulation Research is 3. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-07-01 to 2024-07-01.)

Article	Citations
Cardiac Energy Metabolism in Heart Failure	504
Gut Microbiota and Cardiovascular Disease	471
The Emerging Threat of (Micro)Thrombosis in COVID-19 and Its Therapeutic Implications	438
Epidemiology of Heart Failure	428
Loss of Cardiac Ferritin H Facilitates Cardiomyopathy via Slc7a11-Mediated Ferroptosis	414
Platelets Can Associate With SARS-CoV-2 RNA and Are Hyperactivated in COVID-19	370
SARS-CoV-2 Spike Protein Impairs Endothelial Function via Downregulation of ACE 2	306
Microanatomy of the Human Atherosclerotic Plaque by Single-Cell Transcriptomics	304
Gut Microbiota–Derived Short-Chain Fatty Acids Promote Poststroke Recovery in Aged Mice	291
Obesity, Adipose Tissue and Vascular Dysfunction	291
Interleukin-6 Signaling and Anti-Interleukin-6 Therapeutics in Cardiovascular Disease	279
Basic and Therapeutic Aspects of Angiogenesis Updated	276
Arterial Stiffness and Cardiovascular Risk in Hypertension	259
Social Determinants of Cardiovascular Disease	259
Post-Stroke Cognitive Impairment and Dementia	242
COVID-19 and Cardiovascular Disease	240
Epidemiology of Peripheral Artery Disease and Polyvascular Disease	239
Meta-Analysis of Leukocyte Diversity in Atherosclerotic Mouse Aortas	218
Myofibroblasts and Fibrosis	218
Oxidative Stress and Hypertension	214
Targeting Mitochondria-Inflammation Circuit by β-Hydroxybutyrate Mitigates HFpEF	202
The Impact of Sex and Gender on Stroke	186
In Situ Expansion, Differentiation, and Electromechanical Coupling of Human Cardiac Muscle in a 3D Bioprinted, Chambered Organoid	184
Adiponectin, Leptin and Cardiovascular Disorders	179
GSDMD-Mediated Cardiomyocyte Pyroptosis Promotes Myocardial I/R Injury	164

Atrial Myocyte NLRP3/CaMKII Nexus Forms a Substrate for Postoperative Atrial Fibrillation	163
Cerebral Hemorrhage: Pathophysiology, Treatment, and Future Directions	155
Regulatory T Cells License Macrophage Pro-Resolving Functions During Atherosclerosis Regression	146
From Systemic Inflammation to Myocardial Fibrosis	146
Clonal Hematopoiesis–Driver DNMT3A Mutations Alter Immune Cells in Heart Failure	138
SIRT6 Protects Smooth Muscle Cells From Senescence and Reduces Atherosclerosis	137
SARS-CoV-2 Initiates Programmed Cell Death in Platelets	133
Arterial Stiffness Preceding Diabetes	129
Pathophysiology of Hypertension	126
Dynamics of Cardiac Neutrophil Diversity in Murine Myocardial Infarction	126
Pregnancy and Reproductive Risk Factors for Cardiovascular Disease in Women	123
Hypertension in Low- and Middle-Income Countries	118
Role of the GLUT1 Glucose Transporter in Postnatal CNS Angiogenesis and Blood-Brain Barrier Integrity	116
S100A9 Links Inflammation and Repair in Myocardial Infarction	115
Inflammation, Infection and Venous Thromboembolism	113
Hypertension	111
The Tumor-Suppressive Human Circular RNA CircITCH Sponges miR-330-5p to Ameliorate Doxorubicin-Induced Cardiotoxicity Through Upregulating SIRT6, Survivin, and SERCA2a	110
Reactive Oxygen-Forming Nox5 Links Vascular Smooth Muscle Cell Phenotypic Switching and Extracellular Vesicle-Mediated Vascular Calcification	110
Immune Cells and Immunotherapy for Cardiac Injury and Repair	108
Cardiac Resident Macrophages Prevent Fibrosis and Stimulate Angiogenesis	108
NAD ⁺ Repletion Reverses Heart Failure With Preserved Ejection Fraction	105
Genetic Basis and Therapies for Vascular Anomalies	105
Immune Pathways in Etiology, Acute Phase, and Chronic Sequelae of Ischemic Stroke	99
The Gut Microbiome in Hypertension	98
Lymphatic Malformations: Genetics, Mechanisms and Therapeutic Strategies	96
Molecular Genetic Basis of Hypertrophic Cardiomyopathy	96
Advances in Revascularization for Peripheral Artery Disease: Revascularization in PAD	96
Klotho Deficiency Causes Heart Aging via Impairing the Nrf2-GR Pathway	95
Cerebral Cavernous Malformation: From Mechanism to Therapy	95
Single-Cell Analysis of Blood-Brain Barrier Response to Pericyte Loss	94
Platelet and Vascular Biomarkers Associate With Thrombosis and Death in Coronavirus Disease	93
tPA Mobilizes Immune Cells That Exacerbate Hemorrhagic Transformation in Stroke	91
New Directions in Therapeutic Angiogenesis and Arteriogenesis in Peripheral Arterial Disease	88
Transient Intermittent Hyperglycemia Accelerates Atherosclerosis by Promoting Myelopoiesis	83
Histone Lactylation Boosts Reparative Gene Activation Post–Myocardial Infarction	83
Mir-30d Regulates Cardiac Remodeling by Intracellular and Paracrine Signaling	81
Catecholamines Induce Trained Immunity in Monocytes In Vitro and In Vivo	78
Advances in Acute Ischemic Stroke Therapy	77
Single-Cell Epigenomics and Functional Fine-Mapping of Atherosclerosis GWAS Loci	77
Gut Microbially Produced Indole-3-Propionic Acid Inhibits Atherosclerosis by Promoting Reverse Cholesterol Transport and Its Deficiency Is Causally Related to Atherosclerotic Cardiovascular Disease	77
Racial and Ethnic Disparities in Peripheral Artery Disease	77
The Calcineurin-TFEB-p62 Pathway Mediates the Activation of Cardiac Macroautophagy by Proteasomal Malfunction	76
Somatic Gain of KRAS Function in the Endothelium Is Sufficient to Cause Vascular Malformations That Require MEK but Not PI3K Signaling	75
Sex Differences in Peripheral Artery Disease	74
Endothelial S1P ₁ Signaling Counteracts Infarct Expansion in Ischemic Stroke	73
Innervation and Neuronal Control of the Mammalian Sinoatrial Node a Comprehensive Atlas	73
Pathophysiology and Therapeutic Approaches to Acute Decompensated Heart Failure	71
Pathophysiology and Therapeutic Approaches to Cardiac Amyloidosis	70
KLF5 Is Induced by FOXO1 and Causes Oxidative Stress and Diabetic Cardiomyopathy	69
Deficient Chaperone-Mediated Autophagy Promotes Inflammation and Atherosclerosis	68

Lgr4 Governs a Pro-Inflammatory Program in Macrophages to Antagonize Post-Infarction Cardiac Repair	67
Histone Deacetylase 9 Activates IKK to Regulate Atherosclerotic Plaque Vulnerability	67
Coupling of Integrin α5 to Annexin A2 by Flow Drives Endothelial Activation	66
Guideline-Driven Management of Hypertension	65
Leveraging Machine Learning and Artificial Intelligence to Improve Peripheral Artery Disease Detection, Treatment, and Outcomes	65
JAM-A Acts via C/EBP-α to Promote Claudin-5 Expression and Enhance Endothelial Barrier Function	65
Deletion of BACH1 Attenuates Atherosclerosis by Reducing Endothelial Inflammation	64
Downregulation of LAPTM4B Contributes to the Impairment of the Autophagic Flux via Unopposed Activation of mTORC1 Signaling During Myocardial Ischemia/Reperfusion Injury	63
Multiscale Analysis of Extracellular Matrix Remodeling in the Failing Heart	63
Genetic Regulation of Atherosclerosis-Relevant Phenotypes in Human Vascular Smooth Muscle Cells	63
Hypertension, a Moving Target in COVID-19	63
Epigenetic Age Acceleration Reflects Long-Term Cardiovascular Health	62
Platelet and Megakaryocyte Roles in Innate and Adaptive Immunity	61
Contemporary Medical Management of Peripheral Artery Disease	61
Hypertension and Prohypertensive Antineoplastic Therapies in Cancer Patients	61
Hypoalbuminemia, Coagulopathy, and Vascular Disease in COVID-19	61
Iron-Deficiency and Estrogen Are Associated With Ischemic Stroke by Up-Regulating Transferrin to Induce Hypercoagulability	61
Inflammation Resolution: Implications for Atherosclerosis	60
Sex Differences in Myocardial and Vascular Aging	60
RYR2 Channel Inhibition Is the Principal Mechanism of Flecainide Action in CPVT	59
Mechanisms of Cardiovascular Toxicities Associated With Immunotherapies	57
Nonalcoholic Fatty Liver Disease: An Emerging Driver of Cardiac Arrhythmia	57
Glutamyl-Prolyl-tRNA Synthetase Regulates Proline-Rich Pro-Fibrotic Protein Synthesis During Cardiac Fibrosis	57
COVID-19, Myocarditis and Pericarditis	56
Sex Differences and Similarities in Valvular Heart Disease	56
Endothelial Cell Receptors in Tissue Lipid Uptake and Metabolism	55
Piezo1 Is a Mechanosensor Channel in Central Nervous System Capillaries	55
Extreme Acetylation of the Cardiac Mitochondrial Proteome Does Not Promote Heart Failure	55
SARS-CoV-2 Infection Induces Ferroptosis of Sinoatrial Node Pacemaker Cells	54
The Complex and Diverse Genetic Architecture of Dilated Cardiomyopathy	54
Unveiling Complexity and Multipotentiality of Early Heart Fields	52
CARMN Loss Regulates Smooth Muscle Cells and Accelerates Atherosclerosis in Mice	52
Gut Dysbiosis Promotes Preeclampsia by Regulating Macrophages and Trophoblasts	52
Self-Maintenance of Cardiac Resident Reparative Macrophages Attenuates Doxorubicin-Induced Cardiomyopathy Through the SR-A1-c-Myc Axis	52
CD84 Links T Cell and Platelet Activity in Cerebral Thrombo-Inflammation in Acute Stroke	52
Machine Learning in Arrhythmia and Electrophysiology	52
Gut Microbiome and Neuroinflammation in Hypertension	52
MCU Overexpression Rescues Inotropy and Reverses Heart Failure by Reducing SR Ca ²⁺ Leak	51
CircOGDH Is a Penumbra Biomarker and Therapeutic Target in Acute Ischemic Stroke	51
Small Extracellular Vesicles From Brown Adipose Tissue Mediate Exercise Cardioprotection	51
Restructuring the Gut Microbiota by Intermittent Fasting Lowers Blood Pressure	51
Heart Failure With Preserved Ejection Fraction: Heterogeneous Syndrome, Diverse Preclinical Models	50
Alternative Mitophagy Protects the Heart Against Obesity-Associated Cardiomyopathy	50
The Super-Relaxed State and Length Dependent Activation in Porcine Myocardium	50
The Molecular Basis of Predicting Atherosclerotic Cardiovascular Disease Risk	49
LDL-Cholesterol Reduction by ANGPTL3 Inhibition in Mice Is Dependent on Endothelial Lipase	49
PPARγ-p53-Mediated Vasculoregenerative Program to Reverse Pulmonary Hypertension	48
The Cancer Therapy-Related Clonal Hematopoiesis Driver Gene Ppm1d Promotes Inflammation and Non-Ischemic Heart Failure in Mice	48
Lipid Profiles and Heart Failure Risk	48
Advances in Lymphedema	48
The Latest in Animal Models of Pulmonary Hypertension and Right Ventricular Failure	48
Disrupted Resolution Mechanisms Favor Altered Phagocyte Responses in COVID-19	47
Erythrocyte Metabolic Reprogramming by Sphingosine 1-Phosphate in Chronic Kidney Disease and Therapies	47
Interaction of the Joining Region in Junctophilin-2 With the L-Type Ca ²⁺ Channel Is Pivotal for Cardiac Dyad Assembly and Intracellular Ca ²⁺	47
Faecalibacterium prausnitzii Attenuates CKD via Butyrate-Renal GPR43 Axis	46
Multi-Omics Approaches to Define Calcific Aortic Valve Disease Pathogenesis	46
Aging Microbiota-Gut-Brain Axis in Stroke Risk and Outcome	46
Diabetes Impairs Cellular Cholesterol Efflux From ABCA1 to Small HDL Particles	46
A Neuroligin Isoform Translated by circNlgn Contributes to Cardiac Remodeling	45
MCUb Induction Protects the Heart From Postischemic Remodeling	45
Live Imaging of Intracranial Lymphatics in the Zebrafish	45
Myeloid Cell PKM2 Deletion Enhances Efferocytosis and Reduces Atherosclerosis	44
Illuminating the Mechanisms Underlying Sex Differences in Cardiovascular Disease	44
Cardiac Tissues From Stem Cells	44
Intracellular β ₁ -Adrenergic Receptors and Organic Cation Transporter 3 Mediate Phospholamban Phosphorylation to Enhance Cardiac Contractility	44
LDL Receptor Regulates the Reverse Transport of Macrophage-Derived Unesterified Cholesterol via Concerted Action of the HDL-LDL Axis	44
An Immuno-Cardiac Model for Macrophage-Mediated Inflammation in COVID-19 Hearts	43
DC ENaC-Dependent Inflammasome Activation Contributes to Salt-Sensitive Hypertension	43
Tamoxifen-Activated CreERT Impairs Retinal Angiogenesis Independently of Gene Deletion	43
Generation of Vascular Smooth Muscle Cells From Induced Pluripotent Stem Cells	42
Brain Hypoxia Is Associated With Neuroglial Injury in Humans Post–Cardiac Arrest	42
Immunometabolic Endothelial Phenotypes: Integrating Inflammation and Glucose Metabolism	42
MIR503HG Loss Promotes Endothelial-to-Mesenchymal Transition in Vascular Disease	42
CRISPR Modeling and Correction of Cardiovascular Disease	42
CaMKII Serine 280 O-GlcNAcylation Links Diabetic Hyperglycemia to Proarrhythmia	42
Hyperglycemia Induces Myocardial Dysfunction via Epigenetic Regulation of JunD	41
Infarct Collagen Topography Regulates Fibroblast Fate via p38-Yes-Associated Protein Transcriptional Enhanced Associate Domain Signals	41
Targeting CaMKII-δ9 Ameliorates Cardiac Ischemia/Reperfusion Injury by Inhibiting Myocardial Inflammation	41
Preclinical Models of Cancer Therapy–Associated Cardiovascular Toxicity: A Scientific Statement From the American Heart Association	41
Vascular Dysfunction of COVID-19 Is Partially Reverted in the Long-Term	41

ATAC-Seq Reveals an Isl1 Enhancer That Regulates Sinoatrial Node Development and Function	40
Association Between Atrial Fibrillation and Sudden Cardiac Death	40
Reduced Platelet miR-223 Induction in Kawasaki Disease Leads to Severe Coronary Artery Pathology Through a miR-223/PDGFRβ Vascular Smooth Muscle Cell Axis	40
Exercise Regulates MicroRNAs to Preserve Coronary and Cardiac Function in the Diabetic Heart	40
Reverse Remodeling With Left Ventricular Assist Devices	40
atg7 -Based Autophagy Activation Reverses Doxorubicin-Induced Cardiotoxicity	39
Association of Habitual Physical Activity With Cardiovascular Disease Risk	39
Effects of Atrial Fibrillation on the Human Ventricle	38
Sex-Specific Cardiovascular Risks of Cancer and Its Therapies	38
Unspliced XBP1 Counteracts β-Catenin to Inhibit Vascular Calcification	38
Hypertension as Cardiovascular Risk Factor in Chronic Kidney Disease	38
Ischemia-Selective Cardioprotection by Malonate for Ischemia/Reperfusion Injury	38
Adrenergic Ca _V 1.2 Activation via Rad Phosphorylation Converges at α _1C I-II Loop	37
Periostin	37
Modulation of Mammalian Cardiomyocyte Cytokinesis by the Extracellular Matrix	37
NLRP3 Inflammasome Mediates Immune-Stromal Interactions in Vasculitis	37
Human Coronary Plaque T Cells Are Clonal and Cross-React to Virus and Self	37
GLP1R Attenuates Sympathetic Response to High Glucose via Carotid Body Inhibition	36
Novel Methods for Quantification of Vasodepression and Cardioinhibition During Tilt-Induced Vasovagal Syncope	36
Novel Mechanisms of Exosome-Mediated Phagocytosis of Dead Cells in Injured Heart	36
Sorting Nexin 10 Mediates Metabolic Reprogramming of Macrophages in Atherosclerosis Through the Lyn-Dependent TFEB Signaling Pathway	36
Inflammatory and Biomechanical Drivers of Endothelial-Interstitial Interactions in Calcific Aortic Valve Disease	36
Autophagy Is Differentially Regulated in Leukocyte and Nonleukocyte Foam Cells During Atherosclerosis	36
Zebrafish Models of Cardiac Disease: From Fortuitous Mutants to Precision Medicine	36
Machine Learned Cellular Phenotypes in Cardiomyopathy Predict Sudden Death	36
Platelets and COVID-19	35
Somatic Mutations in Cardiovascular Disease	35
Yap Promotes Noncanonical Wnt Signals From Cardiomyocytes for Heart Regeneration	35
Gut Microbiota-Associated Activation of TLR5 Induces Apolipoprotein A1 Production in the Liver	35
Coronary Arterial Function and Disease in Women With No Obstructive Coronary Arteries	35
Eosinophils Protect Mice From Angiotensin-II Perfusion–Induced Abdominal Aortic Aneurysm	34
Genetic Dissection of a Super Enhancer Controlling the Nppa-Nppb Cluster in the Heart	34
Animal Models of Atherosclerosis–Supportive Notes and Tricks of the Trade	34
CaMKIIδC Drives Early Adaptive Ca ²⁺ Change and Late Eccentric Cardiac Hypertrophy	34
ATF4 Protects the Heart From Failure by Antagonizing Oxidative Stress	34
Mechanisms of Congenital Heart Disease Caused by NAA15 Haploinsufficiency	33
Overexpression of Activin Receptor-Like Kinase 1 in Endothelial Cells Suppresses Development of Arteriovenous Malformations in Mouse Models of Hereditary Hemorrhagic Telangiectasia	33
Sex Differences in Cardiac Rehabilitation Outcomes	33
Ischemic Heart-Derived Small Extracellular Vesicles Impair Adipocyte Function	33
Heart Failure Subtypes and Cardiomyopathies in Women	33
Mitochondrial H ₂ S Regulates BCAA Catabolism in Heart Failure	33
Bioengineering Human Tissues and the Future of Vascular Replacement	33
Device Therapy of Hypertension	33
CalTrack: High-Throughput Automated Calcium Transient Analysis in Cardiomyocytes	33
Reduction of Cardiac Fibrosis by Interference With YAP-Dependent Transactivation	33
Loss of Hepatic Angiotensinogen Attenuates Sepsis-Induced Myocardial Dysfunction	33
Heart Failure With Targeted Cancer Therapies	33
Cellular and Engineered Organoids for Cardiovascular Models	33
Identification of Functional Variant Enhancers Associated With Atrial Fibrillation	33
Cardiovascular Disease Screening in Women: Leveraging Artificial Intelligence and Digital Tools	33
MTORC1-Regulated Metabolism Controlled by TSC2 Limits Cardiac Reperfusion Injury	32
Ketones and the Heart: Metabolic Principles and Therapeutic Implications	32
miR-33 Silencing Reprograms the Immune Cell Landscape in Atherosclerotic Plaques	32
Randomized Trial of Etelcalcetide for Cardiac Hypertrophy in Hemodialysis	32
Butyrate-Rich Diets Improve Redox Status and Fibrin Lysis in Behçet’s Syndrome	32
Epigenomes of Human Hearts Reveal New Genetic Variants Relevant for Cardiac Disease and Phenotype	32
Tenascin-X Mediates Flow-Induced Suppression of EndMT and Atherosclerosis	32
Large and Small Animal Models of Heart Failure With Reduced Ejection Fraction	31
Renin Cells, the Kidney, and Hypertension	31
Circulating Pro-Inflammatory Exosomes Worsen Stroke Outcomes in Aging	30
Artificial Intelligence in Hypertension	30
Niacin Attenuates Pulmonary Hypertension Through H-PGDS in Macrophages	30
cAMP Imaging at Ryanodine Receptors Reveals β ₂ -Adrenoceptor Driven Arrhythmias	30
Dach1 Extends Artery Networks and Protects Against Cardiac Injury	30
The E3 Ligase TRIM16 Is a Key Suppressor of Pathological Cardiac Hypertrophy	30
Variants of Focal Adhesion Scaffold Genes Cause Thoracic Aortic Aneurysm	30
Harnessing Big Data to Advance Treatment and Understanding of Pulmonary Hypertension	30
PKG1α Cysteine-42 Redox State Controls mTORC1 Activation in Pathological Cardiac Hypertrophy	30
Inactivation of ApoC3 by CRISPR/Cas9 Protects Against Atherosclerosis in Hamsters	29
Walking Exercise Therapy Effects on Lower Extremity Skeletal Muscle in Peripheral Artery Disease	29
Endothelial BACE1 Impairs Cerebral Small Vessels via Tight Junctions and eNOS	29
Activation of Autophagic Flux Blunts Cardiac Ischemia/Reperfusion Injury	29
Nonbone Marrow CD34 ⁺ Cells Are Crucial for Endothelial Repair of Injured Artery	29
Silencing Myeloid Netrin-1 Induces Inflammation Resolution and Plaque Regression	29
LncRNA ZNF593-AS Alleviates Contractile Dysfunction in Dilated Cardiomyopathy	29
Myofibroblast Deficiency of LSD1 Alleviates TAC-Induced Heart Failure	29
Current Therapeutic Options in Aortic Stenosis	29
Depletion of Vasohibin 1 Speeds Contraction and Relaxation in Failing Human Cardiomyocytes	29
Role of the Peroxisome Proliferator Activated Receptors in Hypertension	29
High-Density Lipoprotein Carries Markers That Track With Recovery From Stroke	29
KLF2 Mediates the Suppressive Effect of Laminar Flow on Vascular Calcification by Inhibiting Endothelial BMP/SMAD1/5 Signaling	28
Vascular Stress Signaling in Hypertension	28
Nampt Potentiates Antioxidant Defense in Diabetic Cardiomyopathy	28
Epigenomic and Transcriptomic Dynamics During Human Heart Organogenesis	28
Arrhythmias as Presentation of Genetic Cardiomyopathy	28
Wearable Devices in Cardiovascular Medicine	28
Programming to S1PR1 ⁺ Endothelial Cells Promotes Restoration of Vascular Integrity	28
AKAP18δ Anchors and Regulates CaMKII Activity at Phospholamban-SERCA2 and RYR	27
Apo AI Nanoparticles Delivered Post Myocardial Infarction Moderate Inflammation	27
JNK2, a Newly-Identified SERCA2 Enhancer, Augments an Arrhythmic [Ca ²⁺ ] _SR Leak-Load Relationship	27
Targeted Suppression of miRNA-33 Using pHLIP Improves Atherosclerosis Regression	27
Filamin C Cardiomyopathy Variants Cause Protein and Lysosome Accumulation	27
Beat-by-Beat Cardiomyocyte T-Tubule Deformation Drives Tubular Content Exchange	27
New Mutations and Pathogenesis of Pulmonary Hypertension: Progress and Puzzles in Disease Pathogenesis	27
Macrophages, Metabolism and Heterophagy in the Heart	27