OOIR: Observatory of International Research

Papers

(The TQCC of Circulation Research is 2. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-11-01 to 2024-11-01.)

Article	Citations
Cardiac Energy Metabolism in Heart Failure	573
Epidemiology of Heart Failure	473
Platelets Can Associate With SARS-CoV-2 RNA and Are Hyperactivated in COVID-19	372
Obesity, Adipose Tissue and Vascular Dysfunction	330
Microanatomy of the Human Atherosclerotic Plaque by Single-Cell Transcriptomics	324
Social Determinants of Cardiovascular Disease	322
Interleukin-6 Signaling and Anti-Interleukin-6 Therapeutics in Cardiovascular Disease	318
SARS-CoV-2 Spike Protein Impairs Endothelial Function via Downregulation of ACE 2	314
Post-Stroke Cognitive Impairment and Dementia	302
Arterial Stiffness and Cardiovascular Risk in Hypertension	299
Epidemiology of Peripheral Artery Disease and Polyvascular Disease	275
COVID-19 and Cardiovascular Disease	255
Oxidative Stress and Hypertension	241
The Impact of Sex and Gender on Stroke	220
Targeting Mitochondria-Inflammation Circuit by β-Hydroxybutyrate Mitigates HFpEF	216
Adiponectin, Leptin and Cardiovascular Disorders	191
Cerebral Hemorrhage: Pathophysiology, Treatment, and Future Directions	189
GSDMD-Mediated Cardiomyocyte Pyroptosis Promotes Myocardial I/R Injury	175
From Systemic Inflammation to Myocardial Fibrosis	165
Clonal Hematopoiesis–Driver DNMT3A Mutations Alter Immune Cells in Heart Failure	155
Hypertension in Low- and Middle-Income Countries	147
SIRT6 Protects Smooth Muscle Cells From Senescence and Reduces Atherosclerosis	146
Pathophysiology of Hypertension	144
SARS-CoV-2 Initiates Programmed Cell Death in Platelets	141
Pregnancy and Reproductive Risk Factors for Cardiovascular Disease in Women	139

Arterial Stiffness Preceding Diabetes	138
Inflammation, Infection and Venous Thromboembolism	128
Cardiac Resident Macrophages Prevent Fibrosis and Stimulate Angiogenesis	128
Immune Cells and Immunotherapy for Cardiac Injury and Repair	122
Hypertension	121
NAD ⁺ Repletion Reverses Heart Failure With Preserved Ejection Fraction	120
Immune Pathways in Etiology, Acute Phase, and Chronic Sequelae of Ischemic Stroke	117
Molecular Genetic Basis of Hypertrophic Cardiomyopathy	110
Genetic Basis and Therapies for Vascular Anomalies	110
Klotho Deficiency Causes Heart Aging via Impairing the Nrf2-GR Pathway	107
Histone Lactylation Boosts Reparative Gene Activation Post–Myocardial Infarction	106
The Gut Microbiome in Hypertension	106
Advances in Revascularization for Peripheral Artery Disease: Revascularization in PAD	104
Lymphatic Malformations: Genetics, Mechanisms and Therapeutic Strategies	103
Cerebral Cavernous Malformation: From Mechanism to Therapy	99
Single-Cell Analysis of Blood-Brain Barrier Response to Pericyte Loss	99
tPA Mobilizes Immune Cells That Exacerbate Hemorrhagic Transformation in Stroke	97
Advances in Acute Ischemic Stroke Therapy	94
New Directions in Therapeutic Angiogenesis and Arteriogenesis in Peripheral Arterial Disease	93
Gut Microbially Produced Indole-3-Propionic Acid Inhibits Atherosclerosis by Promoting Reverse Cholesterol Transport and Its Deficiency Is Causally Related to Atherosclerotic Cardiovascular Disease	89
Mir-30d Regulates Cardiac Remodeling by Intracellular and Paracrine Signaling	85
Pathophysiology and Therapeutic Approaches to Acute Decompensated Heart Failure	83
Deficient Chaperone-Mediated Autophagy Promotes Inflammation and Atherosclerosis	82
Racial and Ethnic Disparities in Peripheral Artery Disease	82
Sex Differences in Peripheral Artery Disease	81
Pathophysiology and Therapeutic Approaches to Cardiac Amyloidosis	81
Endothelial S1P ₁ Signaling Counteracts Infarct Expansion in Ischemic Stroke	80
Single-Cell Epigenomics and Functional Fine-Mapping of Atherosclerosis GWAS Loci	79
Innervation and Neuronal Control of the Mammalian Sinoatrial Node a Comprehensive Atlas	76
Deletion of BACH1 Attenuates Atherosclerosis by Reducing Endothelial Inflammation	75
KLF5 Is Induced by FOXO1 and Causes Oxidative Stress and Diabetic Cardiomyopathy	73
Leveraging Machine Learning and Artificial Intelligence to Improve Peripheral Artery Disease Detection, Treatment, and Outcomes	72
Guideline-Driven Management of Hypertension	72
Platelet and Megakaryocyte Roles in Innate and Adaptive Immunity	70
COVID-19, Myocarditis and Pericarditis	70
Multiscale Analysis of Extracellular Matrix Remodeling in the Failing Heart	70
Inflammation Resolution: Implications for Atherosclerosis	69
Epigenetic Age Acceleration Reflects Long-Term Cardiovascular Health	69
Sex Differences in Myocardial and Vascular Aging	69
Contemporary Medical Management of Peripheral Artery Disease	67
Hypertension and Prohypertensive Antineoplastic Therapies in Cancer Patients	67
Genetic Regulation of Atherosclerosis-Relevant Phenotypes in Human Vascular Smooth Muscle Cells	65
Sex Differences and Similarities in Valvular Heart Disease	63
Mechanisms of Cardiovascular Toxicities Associated With Immunotherapies	63
Hypertension, a Moving Target in COVID-19	63
Gut Dysbiosis Promotes Preeclampsia by Regulating Macrophages and Trophoblasts	62
Nonalcoholic Fatty Liver Disease: An Emerging Driver of Cardiac Arrhythmia	61
Hypertension as Cardiovascular Risk Factor in Chronic Kidney Disease	61
Endothelial Cell Receptors in Tissue Lipid Uptake and Metabolism	61
The Latest in Animal Models of Pulmonary Hypertension and Right Ventricular Failure	61

CircOGDH Is a Penumbra Biomarker and Therapeutic Target in Acute Ischemic Stroke	60
Restructuring the Gut Microbiota by Intermittent Fasting Lowers Blood Pressure	60
Piezo1 Is a Mechanosensor Channel in Central Nervous System Capillaries	60
Heart Failure With Preserved Ejection Fraction: Heterogeneous Syndrome, Diverse Preclinical Models	60
RYR2 Channel Inhibition Is the Principal Mechanism of Flecainide Action in CPVT	60
Aging Microbiota-Gut-Brain Axis in Stroke Risk and Outcome	60
Alternative Mitophagy Protects the Heart Against Obesity-Associated Cardiomyopathy	59
The Complex and Diverse Genetic Architecture of Dilated Cardiomyopathy	59
Gut Microbiome and Neuroinflammation in Hypertension	59
Machine Learning in Arrhythmia and Electrophysiology	58
Small Extracellular Vesicles From Brown Adipose Tissue Mediate Exercise Cardioprotection	58
SARS-CoV-2 Infection Induces Ferroptosis of Sinoatrial Node Pacemaker Cells	58
Unveiling Complexity and Multipotentiality of Early Heart Fields	57
PPARγ-p53-Mediated Vasculoregenerative Program to Reverse Pulmonary Hypertension	57
The Super-Relaxed State and Length Dependent Activation in Porcine Myocardium	57
The Molecular Basis of Predicting Atherosclerotic Cardiovascular Disease Risk	57
CARMN Loss Regulates Smooth Muscle Cells and Accelerates Atherosclerosis in Mice	56
Myeloid Cell PKM2 Deletion Enhances Efferocytosis and Reduces Atherosclerosis	55
MCU Overexpression Rescues Inotropy and Reverses Heart Failure by Reducing SR Ca ²⁺ Leak	54
DC ENaC-Dependent Inflammasome Activation Contributes to Salt-Sensitive Hypertension	53
Advances in Lymphedema	53
Lipid Profiles and Heart Failure Risk	52
Cardiac Tissues From Stem Cells	52
CRISPR Modeling and Correction of Cardiovascular Disease	52
The Cancer Therapy-Related Clonal Hematopoiesis Driver Gene Ppm1d Promotes Inflammation and Non-Ischemic Heart Failure in Mice	51
Disrupted Resolution Mechanisms Favor Altered Phagocyte Responses in COVID-19	50
Faecalibacterium prausnitzii Attenuates CKD via Butyrate-Renal GPR43 Axis	50
Multi-Omics Approaches to Define Calcific Aortic Valve Disease Pathogenesis	49
Live Imaging of Intracranial Lymphatics in the Zebrafish	49
Interaction of the Joining Region in Junctophilin-2 With the L-Type Ca ²⁺ Channel Is Pivotal for Cardiac Dyad Assembly and Intracellular Ca ²⁺	48
Targeting CaMKII-δ9 Ameliorates Cardiac Ischemia/Reperfusion Injury by Inhibiting Myocardial Inflammation	48
A Neuroligin Isoform Translated by circNlgn Contributes to Cardiac Remodeling	47
atg7 -Based Autophagy Activation Reverses Doxorubicin-Induced Cardiotoxicity	47
An Immuno-Cardiac Model for Macrophage-Mediated Inflammation in COVID-19 Hearts	46
Intracellular β ₁ -Adrenergic Receptors and Organic Cation Transporter 3 Mediate Phospholamban Phosphorylation to Enhance Cardiac Contractility	46
Brain Hypoxia Is Associated With Neuroglial Injury in Humans Post–Cardiac Arrest	46
GLP1R Attenuates Sympathetic Response to High Glucose via Carotid Body Inhibition	46
Preclinical Models of Cancer Therapy–Associated Cardiovascular Toxicity: A Scientific Statement From the American Heart Association	46
Illuminating the Mechanisms Underlying Sex Differences in Cardiovascular Disease	45
Human Coronary Plaque T Cells Are Clonal and Cross-React to Virus and Self	45
Immunometabolic Endothelial Phenotypes: Integrating Inflammation and Glucose Metabolism	45
NLRP3 Inflammasome Mediates Immune-Stromal Interactions in Vasculitis	44
CaMKII Serine 280 O-GlcNAcylation Links Diabetic Hyperglycemia to Proarrhythmia	44
Exercise Regulates MicroRNAs to Preserve Coronary and Cardiac Function in the Diabetic Heart	44
MIR503HG Loss Promotes Endothelial-to-Mesenchymal Transition in Vascular Disease	44
Vascular Dysfunction of COVID-19 Is Partially Reverted in the Long-Term	44
Generation of Vascular Smooth Muscle Cells From Induced Pluripotent Stem Cells	44
Reverse Remodeling With Left Ventricular Assist Devices	44
ATAC-Seq Reveals an Isl1 Enhancer That Regulates Sinoatrial Node Development and Function	43
Effects of Atrial Fibrillation on the Human Ventricle	42
Ischemia-Selective Cardioprotection by Malonate for Ischemia/Reperfusion Injury	42
Unspliced XBP1 Counteracts β-Catenin to Inhibit Vascular Calcification	41
Inflammatory and Biomechanical Drivers of Endothelial-Interstitial Interactions in Calcific Aortic Valve Disease	41
Animal Models of Atherosclerosis–Supportive Notes and Tricks of the Trade	41
Sex-Specific Cardiovascular Risks of Cancer and Its Therapies	40
Autophagy Is Differentially Regulated in Leukocyte and Nonleukocyte Foam Cells During Atherosclerosis	40
Wearable Devices in Cardiovascular Medicine	40
Novel Mechanisms of Exosome-Mediated Phagocytosis of Dead Cells in Injured Heart	40
Adrenergic Ca _V 1.2 Activation via Rad Phosphorylation Converges at α _1C I-II Loop	39
ATF4 Protects the Heart From Failure by Antagonizing Oxidative Stress	39
Ketones and the Heart: Metabolic Principles and Therapeutic Implications	39
Cardiovascular Disease Screening in Women: Leveraging Artificial Intelligence and Digital Tools	38
Mitochondrial H ₂ S Regulates BCAA Catabolism in Heart Failure	38
Device Therapy of Hypertension	38
Heart Failure Subtypes and Cardiomyopathies in Women	38
Bioengineering Human Tissues and the Future of Vascular Replacement	38
Machine Learned Cellular Phenotypes in Cardiomyopathy Predict Sudden Death	38
Somatic Mutations in Cardiovascular Disease	38
Cellular and Engineered Organoids for Cardiovascular Models	38
Zebrafish Models of Cardiac Disease: From Fortuitous Mutants to Precision Medicine	37
Coronary Arterial Function and Disease in Women With No Obstructive Coronary Arteries	37
Eosinophils Protect Mice From Angiotensin-II Perfusion–Induced Abdominal Aortic Aneurysm	37
Heart Failure With Targeted Cancer Therapies	37
Sex Differences in Cardiac Rehabilitation Outcomes	37
Platelets and COVID-19	37
Yap Promotes Noncanonical Wnt Signals From Cardiomyocytes for Heart Regeneration	37
The E3 Ligase TRIM16 Is a Key Suppressor of Pathological Cardiac Hypertrophy	37
Large and Small Animal Models of Heart Failure With Reduced Ejection Fraction	36
Ischemic Heart-Derived Small Extracellular Vesicles Impair Adipocyte Function	36
CalTrack: High-Throughput Automated Calcium Transient Analysis in Cardiomyocytes	36

Reduction of Cardiac Fibrosis by Interference With YAP-Dependent Transactivation	36
Endothelial BACE1 Impairs Cerebral Small Vessels via Tight Junctions and eNOS	36
Tenascin-X Mediates Flow-Induced Suppression of EndMT and Atherosclerosis	36
Nonbone Marrow CD34 ⁺ Cells Are Crucial for Endothelial Repair of Injured Artery	36
Renin Cells, the Kidney, and Hypertension	36
Iron Metabolism in Cardiovascular Disease: Physiology, Mechanisms, and Therapeutic Targets	36
Butyrate-Rich Diets Improve Redox Status and Fibrin Lysis in Behçet’s Syndrome	35
Genetic Dissection of a Super Enhancer Controlling the Nppa-Nppb Cluster in the Heart	35
Endothelial Cell Dysfunction and Increased Cardiovascular Risk in Patients With Chronic Kidney Disease	35
Mechanisms of Congenital Heart Disease Caused by NAA15 Haploinsufficiency	34
Critical Role of the cGAS-STING Pathway in Doxorubicin-Induced Cardiotoxicity	34
Loss of Hepatic Angiotensinogen Attenuates Sepsis-Induced Myocardial Dysfunction	34
Matricellular Protein Cilp1 Promotes Myocardial Fibrosis in Response to Myocardial Infarction	33
New Mutations and Pathogenesis of Pulmonary Hypertension: Progress and Puzzles in Disease Pathogenesis	33
Artificial Intelligence in Hypertension	33
MTORC1-Regulated Metabolism Controlled by TSC2 Limits Cardiac Reperfusion Injury	33
Current Therapeutic Options in Aortic Stenosis	33
Circulating Pro-Inflammatory Exosomes Worsen Stroke Outcomes in Aging	33
Cardiopulmonary Consequences of Vaping in Adolescents: A Scientific Statement From the American Heart Association	33
Randomized Trial of Etelcalcetide for Cardiac Hypertrophy in Hemodialysis	33
Modulating Lysine Crotonylation in Cardiomyocytes Improves Myocardial Outcomes	33
Dach1 Extends Artery Networks and Protects Against Cardiac Injury	33
miR-33 Silencing Reprograms the Immune Cell Landscape in Atherosclerotic Plaques	33
Harnessing Big Data to Advance Treatment and Understanding of Pulmonary Hypertension	32
Targeting SIRT1 Rescues Age- and Obesity-Induced Microvascular Dysfunction in Ex Vivo Human Vessels	32
Macrophages, Metabolism and Heterophagy in the Heart	32
Variants of Focal Adhesion Scaffold Genes Cause Thoracic Aortic Aneurysm	32
Myofibroblast Deficiency of LSD1 Alleviates TAC-Induced Heart Failure	32
Arrhythmias as Presentation of Genetic Cardiomyopathy	31
Fibroblast GSK-3α Promotes Fibrosis via RAF-MEK-ERK Pathway in the Injured Heart	31
Activation of Autophagic Flux Blunts Cardiac Ischemia/Reperfusion Injury	31
Silencing Myeloid Netrin-1 Induces Inflammation Resolution and Plaque Regression	31
LncRNA ZNF593-AS Alleviates Contractile Dysfunction in Dilated Cardiomyopathy	31
cAMP Imaging at Ryanodine Receptors Reveals β ₂ -Adrenoceptor Driven Arrhythmias	31
USP25 Ameliorates Pathological Cardiac Hypertrophy by Stabilizing SERCA2a in Cardiomyocytes	31
Role of the Peroxisome Proliferator Activated Receptors in Hypertension	31
Nampt Potentiates Antioxidant Defense in Diabetic Cardiomyopathy	30
Walking Exercise Therapy Effects on Lower Extremity Skeletal Muscle in Peripheral Artery Disease	30
KLF2 Mediates the Suppressive Effect of Laminar Flow on Vascular Calcification by Inhibiting Endothelial BMP/SMAD1/5 Signaling	30
Apo AI Nanoparticles Delivered Post Myocardial Infarction Moderate Inflammation	30
Programming to S1PR1 ⁺ Endothelial Cells Promotes Restoration of Vascular Integrity	30
Inactivation of ApoC3 by CRISPR/Cas9 Protects Against Atherosclerosis in Hamsters	30
PHB2 Maintains the Contractile Phenotype of VSMCs by Counteracting PKM2 Splicing	30
miR-223 Exerts Translational Control of Proatherogenic Genes in Macrophages	29
Endothelial Senescence: A New Age in Pulmonary Hypertension	29
JNK2, a Newly-Identified SERCA2 Enhancer, Augments an Arrhythmic [Ca ²⁺ ] _SR Leak-Load Relationship	29
Intrinsic Electrical Remodeling Underlies Atrioventricular Block in Athletes	29
A Novel Mechanism Underlying Inflammatory Smooth Muscle Phenotype in Abdominal Aortic Aneurysm	29
Inhibition of IL11 Signaling Reduces Aortic Pathology in Murine Marfan Syndrome	29
Targeted Suppression of miRNA-33 Using pHLIP Improves Atherosclerosis Regression	29
Vascular Stress Signaling in Hypertension	29
Endothelial UCP2 Is a Mechanosensitive Suppressor of Atherosclerosis	29
Growth Arrest Specific-6 and Axl Coordinate Inflammation and Hypertension	28
Cardiovascular Calcification Heterogeneity in Chronic Kidney Disease	28
Efficient Correction of a Hypertrophic Cardiomyopathy Mutation by ABEmax-NG	28
LPA ₂ Contributes to Vascular Endothelium Homeostasis and Cardiac Remodeling After Myocardial Infarction	28
Cardiorenal Syndrome: The Role of Neural Connections Between the Heart and the Kidneys	28
VE-Cadherin Is Required for Cardiac Lymphatic Maintenance and Signaling	28
Transcriptional and Immune Landscape of Cardiac Sarcoidosis	28
Animal Models to Study Cardiac Arrhythmias	28
Different DOACs Control Inflammation in Cardiac Ischemia-Reperfusion Differently	28
Group 3 Pulmonary Hypertension: From Bench to Bedside	28
Targeting PDE4B (Phosphodiesterase-4 Subtype B) for Cardioprotection in Acute Myocardial Infarction via Neutrophils and Microcirculation	28
Filamin C Cardiomyopathy Variants Cause Protein and Lysosome Accumulation	28
Beat-by-Beat Cardiomyocyte T-Tubule Deformation Drives Tubular Content Exchange	28
Extracellular Vesicles Regulate Sympatho-Excitation by Nrf2 in Heart Failure	27
Genetic, Molecular, and Cellular Determinants of Sex-Specific Cardiovascular Traits	27
Epidemiology and Genetics of Venous Thromboembolism and Chronic Venous Disease	27
Piezo1-Regulated Mechanotransduction Controls Flow-Activated Lymphatic Expansion	27
Renin Cell Baroreceptor, a Nuclear Mechanotransducer Central for Homeostasis	27
Proprotein Convertase Subtilisin/Kexin 9 (PCSK9) Promotes Macrophage Activation via LDL Receptor-Independent Mechanisms	27
Trajectories of Blood Pressure in Midlife Women: Does Menopause Matter?	27
AKAP18δ Anchors and Regulates CaMKII Activity at Phospholamban-SERCA2 and RYR	27
Stroke Proteomics: From Discovery to Diagnostic and Therapeutic Applications	27
Orai1 Inhibitors as Potential Treatments for Pulmonary Arterial Hypertension	26
Intrapericardial Exosome Therapy Dampens Cardiac Injury via Activating Foxo3	26
Molecular Imaging of Inflammation and Fibrosis in Pressure Overload Heart Failure	26
Persisting Platelet Activation and Hyperactivity in COVID-19 Survivors	26
Locus-Conserved Circular RNA cZNF292 Controls Endothelial Cell Flow Responses	26
Arrhythmias in Female Patients: Incidence, Presentation and Management	26
Heterodimerization With 5-HT _2B R Is Indispensable for β ₂ AR-Mediated Cardioprotection	26
Noncanonical HIPPO/MST Signaling via BUB3 and FOXO Drives Pulmonary Vascular Cell Growth and Survival	25
Arsenic Exposure, Blood DNA Methylation, and Cardiovascular Disease	25
Arterial Stiffness and Diabetes Risk in Framingham Heart Study and UK Biobank	25
Targeting the Microtubule EB1-CLASP2 Complex Modulates Na _V 1.5 at Intercalated Discs	25
FMD and SCAD: Sex-Biased Arterial Diseases With Clinical and Genetic Pleiotropy	25
SIRT6 Mitigates Heart Failure With Preserved Ejection Fraction in Diabetes	25
Cerebrovascular Complications of COVID-19 and COVID-19 Vaccination	25
Sca1 ⁺ Cells Minimally Contribute to Smooth Muscle Cells in Atherosclerosis	25
CIRKIL Exacerbates Cardiac Ischemia/Reperfusion Injury by Interacting With Ku70	25
ZBP1 Protects Against mtDNA-Induced Myocardial Inflammation in Failing Hearts	24
Tubular IL-1β Induces Salt Sensitivity in Diabetes by Activating Renal Macrophages	24
Platelets and SARS-CoV-2 During COVID-19: Immunity, Thrombosis, and Beyond	24
Genome-Wide Analysis Identifies an Essential Human TBX3 Pacemaker Enhancer	24
Coronary Disease Association With ADAMTS7 Is Due to Protease Activity	24