Circulation Research

(The TQCC of Circulation Research is 3. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-05-01 to 2024-05-01.)
Angiotensin-Converting Enzyme 2: SARS-CoV-2 Receptor and Regulator of the Renin-Angiotensin System1384
Association of Inpatient Use of Angiotensin-Converting Enzyme Inhibitors and Angiotensin II Receptor Blockers With Mortality Among Patients With Hypertension Hospitalized With COVID-19749
Obesity Phenotypes, Diabetes, and Cardiovascular Diseases741
Epidemiology of Atrial Fibrillation in the 21st Century632
COVID-19 and the Heart522
Cardiac Energy Metabolism in Heart Failure456
Metabolic Inflammation and Insulin Resistance in Obesity447
Gut Microbiota and Cardiovascular Disease439
The Emerging Threat of (Micro)Thrombosis in COVID-19 and Its Therapeutic Implications434
Epidemiology of Heart Failure392
Loss of Cardiac Ferritin H Facilitates Cardiomyopathy via Slc7a11-Mediated Ferroptosis390
Platelets Can Associate With SARS-CoV-2 RNA and Are Hyperactivated in COVID-19363
SARS-CoV-2 Spike Protein Impairs Endothelial Function via Downregulation of ACE 2295
Basic Mechanisms of Diabetic Heart Disease288
Microanatomy of the Human Atherosclerotic Plaque by Single-Cell Transcriptomics287
Gut Microbiota–Derived Short-Chain Fatty Acids Promote Poststroke Recovery in Aged Mice269
Obesity, Adipose Tissue and Vascular Dysfunction257
Basic and Therapeutic Aspects of Angiogenesis Updated255
Interleukin-6 Signaling and Anti-Interleukin-6 Therapeutics in Cardiovascular Disease245
COVID-19 and Cardiovascular Disease231
Arterial Stiffness and Cardiovascular Risk in Hypertension228
Molecular Basis of Atrial Fibrillation Pathophysiology and Therapy227
Social Determinants of Cardiovascular Disease222
Epidemiology of Peripheral Artery Disease and Polyvascular Disease214
Post-Stroke Cognitive Impairment and Dementia211
Meta-Analysis of Leukocyte Diversity in Atherosclerotic Mouse Aortas205
Myofibroblasts and Fibrosis195
Oxidative Stress and Hypertension193
Targeting Mitochondria-Inflammation Circuit by β-Hydroxybutyrate Mitigates HFpEF192
In Situ Expansion, Differentiation, and Electromechanical Coupling of Human Cardiac Muscle in a 3D Bioprinted, Chambered Organoid173
The Impact of Sex and Gender on Stroke164
Adiponectin, Leptin and Cardiovascular Disorders163
Atrial Myocyte NLRP3/CaMKII Nexus Forms a Substrate for Postoperative Atrial Fibrillation153
GSDMD-Mediated Cardiomyocyte Pyroptosis Promotes Myocardial I/R Injury153
From Systemic Inflammation to Myocardial Fibrosis137
Regulatory T Cells License Macrophage Pro-Resolving Functions During Atherosclerosis Regression135
SIRT6 Protects Smooth Muscle Cells From Senescence and Reduces Atherosclerosis130
Clonal Hematopoiesis–Driver DNMT3A Mutations Alter Immune Cells in Heart Failure129
Cerebral Hemorrhage: Pathophysiology, Treatment, and Future Directions129
SARS-CoV-2 Initiates Programmed Cell Death in Platelets128
Pathophysiology of Hypertension121
Arterial Stiffness Preceding Diabetes119
Dynamics of Cardiac Neutrophil Diversity in Murine Myocardial Infarction116
Genetics of Atrial Fibrillation in 2020114
Pregnancy and Reproductive Risk Factors for Cardiovascular Disease in Women110
Hypertension in Low- and Middle-Income Countries108
S100A9 Links Inflammation and Repair in Myocardial Infarction106
Reactive Oxygen-Forming Nox5 Links Vascular Smooth Muscle Cell Phenotypic Switching and Extracellular Vesicle-Mediated Vascular Calcification105
Role of the GLUT1 Glucose Transporter in Postnatal CNS Angiogenesis and Blood-Brain Barrier Integrity105
The Tumor-Suppressive Human Circular RNA CircITCH Sponges miR-330-5p to Ameliorate Doxorubicin-Induced Cardiotoxicity Through Upregulating SIRT6, Survivin, and SERCA2a104
Inflammation, Infection and Venous Thromboembolism99
NAD + Repletion Reverses Heart Failure With Preserved Ejection Fraction99
Immune Cells and Immunotherapy for Cardiac Injury and Repair97
Cardiac Resident Macrophages Prevent Fibrosis and Stimulate Angiogenesis95
Atherogenic Lipoprotein(a) Increases Vascular Glycolysis, Thereby Facilitating Inflammation and Leukocyte Extravasation93
Single-Cell Analysis of Blood-Brain Barrier Response to Pericyte Loss92
Genetic Basis and Therapies for Vascular Anomalies92
Lymphatic Malformations: Genetics, Mechanisms and Therapeutic Strategies89
The Gut Microbiome in Hypertension89
Klotho Deficiency Causes Heart Aging via Impairing the Nrf2-GR Pathway89
Platelet and Vascular Biomarkers Associate With Thrombosis and Death in Coronavirus Disease88
Cerebral Cavernous Malformation: From Mechanism to Therapy87
Molecular Genetic Basis of Hypertrophic Cardiomyopathy87
AP-1 Contributes to Chromatin Accessibility to Promote Sarcomere Disassembly and Cardiomyocyte Protrusion During Zebrafish Heart Regeneration86
miR-128-3p Is a Novel Regulator of Vascular Smooth Muscle Cell Phenotypic Switch and Vascular Diseases86
Metabolomics and Proteomics in Type 2 Diabetes85
tPA Mobilizes Immune Cells That Exacerbate Hemorrhagic Transformation in Stroke84
Gene Therapy for the Heart Lessons Learned and Future Perspectives84
Advances in Revascularization for Peripheral Artery Disease: Revascularization in PAD82
A Critical Role for Estrogen-Related Receptor Signaling in Cardiac Maturation82
Epigenetic Metabolic Reprogramming of Right Ventricular Fibroblasts in Pulmonary Arterial Hypertension82
Animal Models of Atrial Fibrillation81
Hyperglycemia Acutely Increases Cytosolic Reactive Oxygen Species via O -linked GlcNAcylation and CaMKII Activation in Mouse Ventricular Myocytes81
New Directions in Therapeutic Angiogenesis and Arteriogenesis in Peripheral Arterial Disease81
Transient Intermittent Hyperglycemia Accelerates Atherosclerosis by Promoting Myelopoiesis79
Immune Pathways in Etiology, Acute Phase, and Chronic Sequelae of Ischemic Stroke78
Mir-30d Regulates Cardiac Remodeling by Intracellular and Paracrine Signaling74
Catecholamines Induce Trained Immunity in Monocytes In Vitro and In Vivo74
The Calcineurin-TFEB-p62 Pathway Mediates the Activation of Cardiac Macroautophagy by Proteasomal Malfunction73
Endothelial S1P 1 Signaling Counteracts Infarct Expansion in Ischemic Stroke71
Advances in Acute Ischemic Stroke Therapy71
Somatic Gain of KRAS Function in the Endothelium Is Sufficient to Cause Vascular Malformations That Require MEK but Not PI3K Signaling69
Single-Cell Epigenomics and Functional Fine-Mapping of Atherosclerosis GWAS Loci68
Sex Differences in Peripheral Artery Disease67
Response by Zhang et al to Letter Regarding Article, “Association of Inpatient Use of Angiotensin-Converting Enzyme Inhibitors and Angiotensin II Receptor Blockers With Mortality Among Patients With H66
Innervation and Neuronal Control of the Mammalian Sinoatrial Node a Comprehensive Atlas66
Pathophysiology and Therapeutic Approaches to Acute Decompensated Heart Failure65
Pathophysiology and Therapeutic Approaches to Cardiac Amyloidosis64
Gut Microbially Produced Indole-3-Propionic Acid Inhibits Atherosclerosis by Promoting Reverse Cholesterol Transport and Its Deficiency Is Causally Related to Atherosclerotic Cardiovascular Disease63
Racial and Ethnic Disparities in Peripheral Artery Disease63
Genetic Regulation of Atherosclerosis-Relevant Phenotypes in Human Vascular Smooth Muscle Cells62
Multiscale Analysis of Extracellular Matrix Remodeling in the Failing Heart62
Deficient Chaperone-Mediated Autophagy Promotes Inflammation and Atherosclerosis62
Coupling of Integrin α5 to Annexin A2 by Flow Drives Endothelial Activation62
Inflammasomes and Proteostasis Novel Molecular Mechanisms Associated With Atrial Fibrillation62
Lgr4 Governs a Pro-Inflammatory Program in Macrophages to Antagonize Post-Infarction Cardiac Repair62
Downregulation of LAPTM4B Contributes to the Impairment of the Autophagic Flux via Unopposed Activation of mTORC1 Signaling During Myocardial Ischemia/Reperfusion Injury62
Histone Deacetylase 9 Activates IKK to Regulate Atherosclerotic Plaque Vulnerability62
JAM-A Acts via C/EBP-α to Promote Claudin-5 Expression and Enhance Endothelial Barrier Function62
Histone Lactylation Boosts Reparative Gene Activation Post–Myocardial Infarction61
Iron-Deficiency and Estrogen Are Associated With Ischemic Stroke by Up-Regulating Transferrin to Induce Hypercoagulability61
Leveraging Machine Learning and Artificial Intelligence to Improve Peripheral Artery Disease Detection, Treatment, and Outcomes61
Deletion of BACH1 Attenuates Atherosclerosis by Reducing Endothelial Inflammation60
KLF5 Is Induced by FOXO1 and Causes Oxidative Stress and Diabetic Cardiomyopathy60
Hypertension, a Moving Target in COVID-1959
Genetics Insights in the Relationship Between Type 2 Diabetes and Coronary Heart Disease58
Population-Based Screening for Atrial Fibrillation58
Hypoalbuminemia, Coagulopathy, and Vascular Disease in COVID-1958
Epigenetic Age Acceleration Reflects Long-Term Cardiovascular Health57
Hypertension and Prohypertensive Antineoplastic Therapies in Cancer Patients57
Contemporary Medical Management of Peripheral Artery Disease57
Guideline-Driven Management of Hypertension56
RYR2 Channel Inhibition Is the Principal Mechanism of Flecainide Action in CPVT56
Sex Differences in Myocardial and Vascular Aging56
Nonalcoholic Fatty Liver Disease: An Emerging Driver of Cardiac Arrhythmia56
Extreme Acetylation of the Cardiac Mitochondrial Proteome Does Not Promote Heart Failure55
Inflammation Resolution: Implications for Atherosclerosis53
Endothelial Cell Receptors in Tissue Lipid Uptake and Metabolism53
Platelet and Megakaryocyte Roles in Innate and Adaptive Immunity53
Emerging Technologies for Identifying Atrial Fibrillation52
CD84 Links T Cell and Platelet Activity in Cerebral Thrombo-Inflammation in Acute Stroke52
Glutamyl-Prolyl-tRNA Synthetase Regulates Proline-Rich Pro-Fibrotic Protein Synthesis During Cardiac Fibrosis52
The Complex and Diverse Genetic Architecture of Dilated Cardiomyopathy50
Metabolic and Molecular Imaging of the Diabetic Cardiomyopathy50
Mechanisms of Cardiovascular Toxicities Associated With Immunotherapies49
Unveiling Complexity and Multipotentiality of Early Heart Fields49
CARMN Loss Regulates Smooth Muscle Cells and Accelerates Atherosclerosis in Mice49
Piezo1 Is a Mechanosensor Channel in Central Nervous System Capillaries49
SARS-CoV-2 Infection Induces Ferroptosis of Sinoatrial Node Pacemaker Cells49
Gut Microbiome and Neuroinflammation in Hypertension48
Alternative Mitophagy Protects the Heart Against Obesity-Associated Cardiomyopathy48
MCU Overexpression Rescues Inotropy and Reverses Heart Failure by Reducing SR Ca 2+ Leak48
Machine Learning in Arrhythmia and Electrophysiology48
Self-Maintenance of Cardiac Resident Reparative Macrophages Attenuates Doxorubicin-Induced Cardiomyopathy Through the SR-A1-c-Myc Axis48
CircOGDH Is a Penumbra Biomarker and Therapeutic Target in Acute Ischemic Stroke48
Restructuring the Gut Microbiota by Intermittent Fasting Lowers Blood Pressure48
Emerging Technologies for Pulmonary Vein Isolation48
The Super-Relaxed State and Length Dependent Activation in Porcine Myocardium47
The Molecular Basis of Predicting Atherosclerotic Cardiovascular Disease Risk46
Epigenetic and Transcriptional Networks Underlying Atrial Fibrillation46
Interaction of the Joining Region in Junctophilin-2 With the L-Type Ca 2+ Channel Is Pivotal for Cardiac Dyad Assembly and Intracellular Ca 2+46
LDL-Cholesterol Reduction by ANGPTL3 Inhibition in Mice Is Dependent on Endothelial Lipase46
Sex Differences and Similarities in Valvular Heart Disease45
Gut Dysbiosis Promotes Preeclampsia by Regulating Macrophages and Trophoblasts45
Small Extracellular Vesicles From Brown Adipose Tissue Mediate Exercise Cardioprotection45
Reactivation of the Epicardium at the Origin of Myocardial Fibro-Fatty Infiltration During the Atrial Cardiomyopathy45
COVID-19, Myocarditis and Pericarditis45
Disrupted Resolution Mechanisms Favor Altered Phagocyte Responses in COVID-1945
Leukocyte Heterogeneity in Adipose Tissue, Including in Obesity45
Heart Failure With Preserved Ejection Fraction: Heterogeneous Syndrome, Diverse Preclinical Models44
Erythrocyte Metabolic Reprogramming by Sphingosine 1-Phosphate in Chronic Kidney Disease and Therapies44
LDL Receptor Regulates the Reverse Transport of Macrophage-Derived Unesterified Cholesterol via Concerted Action of the HDL-LDL Axis44
A Neuroligin Isoform Translated by circNlgn Contributes to Cardiac Remodeling44
The Cancer Therapy-Related Clonal Hematopoiesis Driver Gene Ppm1d Promotes Inflammation and Non-Ischemic Heart Failure in Mice43
Diabetes Impairs Cellular Cholesterol Efflux From ABCA1 to Small HDL Particles43
Advances in Lymphedema43
Aging Microbiota-Gut-Brain Axis in Stroke Risk and Outcome43
An Immuno-Cardiac Model for Macrophage-Mediated Inflammation in COVID-19 Hearts42
EHD1 Modulates Cx43 Gap Junction Remodeling Associated With Cardiac Diseases42
PPARγ-p53-Mediated Vasculoregenerative Program to Reverse Pulmonary Hypertension42
Lipid Profiles and Heart Failure Risk41
Live Imaging of Intracranial Lymphatics in the Zebrafish41
Infarct Collagen Topography Regulates Fibroblast Fate via p38-Yes-Associated Protein Transcriptional Enhanced Associate Domain Signals41
Cardiac Tissues From Stem Cells41
Hyperglycemia Induces Myocardial Dysfunction via Epigenetic Regulation of JunD40
Intracellular β 1 -Adrenergic Receptors and Organic Cation Transporter 3 Mediate Phospholamban Phosphorylation to Enhance Cardiac Contractility40
Multi-Omics Approaches to Define Calcific Aortic Valve Disease Pathogenesis40
MIR503HG Loss Promotes Endothelial-to-Mesenchymal Transition in Vascular Disease40
Illuminating the Mechanisms Underlying Sex Differences in Cardiovascular Disease39
The Latest in Animal Models of Pulmonary Hypertension and Right Ventricular Failure39
Faecalibacterium prausnitzii Attenuates CKD via Butyrate-Renal GPR43 Axis39
Vascular Dysfunction of COVID-19 Is Partially Reverted in the Long-Term39
Exercise Regulates MicroRNAs to Preserve Coronary and Cardiac Function in the Diabetic Heart38
CRISPR Modeling and Correction of Cardiovascular Disease38
Association Between Atrial Fibrillation and Sudden Cardiac Death38
CaMKII Serine 280 O-GlcNAcylation Links Diabetic Hyperglycemia to Proarrhythmia38
Immunometabolic Endothelial Phenotypes: Integrating Inflammation and Glucose Metabolism38
MCUb Induction Protects the Heart From Postischemic Remodeling38
Myeloid Cell PKM2 Deletion Enhances Efferocytosis and Reduces Atherosclerosis38
Brain Hypoxia Is Associated With Neuroglial Injury in Humans Post–Cardiac Arrest38
Reverse Remodeling With Left Ventricular Assist Devices38
Tamoxifen-Activated CreERT Impairs Retinal Angiogenesis Independently of Gene Deletion38
Generation of Vascular Smooth Muscle Cells From Induced Pluripotent Stem Cells37
Adrenergic Ca V 1.2 Activation via Rad Phosphorylation Converges at α 1C I-II Loop37
Nutrition, Thrombosis, and Cardiovascular Disease37
Preclinical Models of Cancer Therapy–Associated Cardiovascular Toxicity: A Scientific Statement From the American Heart Association37
Treatment of Obesity in Mitigating Metabolic Risk37
Reduced Platelet miR-223 Induction in Kawasaki Disease Leads to Severe Coronary Artery Pathology Through a miR-223/PDGFRβ Vascular Smooth Muscle Cell Axis37
Targeting CaMKII-δ9 Ameliorates Cardiac Ischemia/Reperfusion Injury by Inhibiting Myocardial Inflammation37
DC ENaC-Dependent Inflammasome Activation Contributes to Salt-Sensitive Hypertension36
Association of Habitual Physical Activity With Cardiovascular Disease Risk36
ATAC-Seq Reveals an Isl1 Enhancer That Regulates Sinoatrial Node Development and Function36
Modulation of Mammalian Cardiomyocyte Cytokinesis by the Extracellular Matrix36
Novel Methods for Quantification of Vasodepression and Cardioinhibition During Tilt-Induced Vasovagal Syncope36
Machine Learned Cellular Phenotypes in Cardiomyopathy Predict Sudden Death36
How Will Machine Learning Inform the Clinical Care of Atrial Fibrillation?35
Platelets and COVID-1935
atg7 -Based Autophagy Activation Reverses Doxorubicin-Induced Cardiotoxicity35
Gut Microbiota-Associated Activation of TLR5 Induces Apolipoprotein A1 Production in the Liver34
Effects of Atrial Fibrillation on the Human Ventricle34
GLP1R Attenuates Sympathetic Response to High Glucose via Carotid Body Inhibition34
Ischemia-Selective Cardioprotection by Malonate for Ischemia/Reperfusion Injury34
Loss of Hepatic Angiotensinogen Attenuates Sepsis-Induced Myocardial Dysfunction33
Autophagy Is Differentially Regulated in Leukocyte and Nonleukocyte Foam Cells During Atherosclerosis33
Sex-Specific Cardiovascular Risks of Cancer and Its Therapies33
Genetic Dissection of a Super Enhancer Controlling the Nppa-Nppb Cluster in the Heart33
Sorting Nexin 10 Mediates Metabolic Reprogramming of Macrophages in Atherosclerosis Through the Lyn-Dependent TFEB Signaling Pathway33
Eosinophils Protect Mice From Angiotensin-II Perfusion–Induced Abdominal Aortic Aneurysm33
Novel Mechanisms of Exosome-Mediated Phagocytosis of Dead Cells in Injured Heart33
Somatic Mutations in Cardiovascular Disease32
Zebrafish Models of Cardiac Disease: From Fortuitous Mutants to Precision Medicine32
Sex Differences in Cardiac Rehabilitation Outcomes32
CalTrack: High-Throughput Automated Calcium Transient Analysis in Cardiomyocytes32
CaMKIIδC Drives Early Adaptive Ca 2+ Change and Late Eccentric Cardiac Hypertrophy32
Heart Failure With Targeted Cancer Therapies32
Device Therapy of Hypertension32
Randomized Trial of Etelcalcetide for Cardiac Hypertrophy in Hemodialysis32
Inflammatory and Biomechanical Drivers of Endothelial-Interstitial Interactions in Calcific Aortic Valve Disease32
Yap Promotes Noncanonical Wnt Signals From Cardiomyocytes for Heart Regeneration32
Targeting Myeloid-Specific Integrin α9β1 Improves Short- and Long-Term Stroke Outcomes in Murine Models With Preexisting Comorbidities by Limiting Thrombosis and Inflammation32
Hypertension as Cardiovascular Risk Factor in Chronic Kidney Disease31
ATF4 Protects the Heart From Failure by Antagonizing Oxidative Stress31
Identification of Functional Variant Enhancers Associated With Atrial Fibrillation31
Mitochondrial H 2 S Regulates BCAA Catabolism in Heart Failure31
Unspliced XBP1 Counteracts β-Catenin to Inhibit Vascular Calcification31
NLRP3 Inflammasome Mediates Immune-Stromal Interactions in Vasculitis31
Butyrate-Rich Diets Improve Redox Status and Fibrin Lysis in Behçet’s Syndrome31
Cardiovascular Disease Screening in Women: Leveraging Artificial Intelligence and Digital Tools30
Cellular and Engineered Organoids for Cardiovascular Models30
Heart Failure Subtypes and Cardiomyopathies in Women30
Niacin Attenuates Pulmonary Hypertension Through H-PGDS in Macrophages30
Coronary Arterial Function and Disease in Women With No Obstructive Coronary Arteries30
Tenascin-X Mediates Flow-Induced Suppression of EndMT and Atherosclerosis30
Epigenomes of Human Hearts Reveal New Genetic Variants Relevant for Cardiac Disease and Phenotype29
Inactivation of ApoC3 by CRISPR/Cas9 Protects Against Atherosclerosis in Hamsters29
MTORC1-Regulated Metabolism Controlled by TSC2 Limits Cardiac Reperfusion Injury29
Role of the Peroxisome Proliferator Activated Receptors in Hypertension29
Nampt Potentiates Antioxidant Defense in Diabetic Cardiomyopathy28
Overexpression of Activin Receptor-Like Kinase 1 in Endothelial Cells Suppresses Development of Arteriovenous Malformations in Mouse Models of Hereditary Hemorrhagic Telangiectasia28
PKG1α Cysteine-42 Redox State Controls mTORC1 Activation in Pathological Cardiac Hypertrophy28
Activation of Autophagic Flux Blunts Cardiac Ischemia/Reperfusion Injury28
Depletion of Vasohibin 1 Speeds Contraction and Relaxation in Failing Human Cardiomyocytes28
Epigenomic and Transcriptomic Dynamics During Human Heart Organogenesis28
Ischemic Heart-Derived Small Extracellular Vesicles Impair Adipocyte Function28
Myofibroblast Deficiency of LSD1 Alleviates TAC-Induced Heart Failure28
Animal Models of Atherosclerosis–Supportive Notes and Tricks of the Trade28
Human Coronary Plaque T Cells Are Clonal and Cross-React to Virus and Self28
Renin Cells, the Kidney, and Hypertension28