OOIR: Observatory of International Research

Papers

(The median citation count of Circulation Research is 0. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-04-01 to 2024-04-01.)

Article	Citations
Angiotensin-Converting Enzyme 2: SARS-CoV-2 Receptor and Regulator of the Renin-Angiotensin System	1373
Association of Inpatient Use of Angiotensin-Converting Enzyme Inhibitors and Angiotensin II Receptor Blockers With Mortality Among Patients With Hypertension Hospitalized With COVID-19	743
Obesity Phenotypes, Diabetes, and Cardiovascular Diseases	697
Epidemiology of Atrial Fibrillation in the 21st Century	608
COVID-19 and the Heart	519
Cardiac Energy Metabolism in Heart Failure	436
Metabolic Inflammation and Insulin Resistance in Obesity	429
The Emerging Threat of (Micro)Thrombosis in COVID-19 and Its Therapeutic Implications	428
Gut Microbiota and Cardiovascular Disease	423
Interleukin-1 and the Inflammasome as Therapeutic Targets in Cardiovascular Disease	391
Loss of Cardiac Ferritin H Facilitates Cardiomyopathy via Slc7a11-Mediated Ferroptosis	374
Epidemiology of Heart Failure	370
Platelets Can Associate With SARS-CoV-2 RNA and Are Hyperactivated in COVID-19	360
Cardiomyocyte Maturation	346
SARS-CoV-2 Spike Protein Impairs Endothelial Function via Downregulation of ACE 2	289
Microanatomy of the Human Atherosclerotic Plaque by Single-Cell Transcriptomics	281
Basic Mechanisms of Diabetic Heart Disease	275
Gut Microbiota–Derived Short-Chain Fatty Acids Promote Poststroke Recovery in Aged Mice	255
Obesity, Adipose Tissue and Vascular Dysfunction	248
Basic and Therapeutic Aspects of Angiogenesis Updated	246
Interleukin-6 Signaling and Anti-Interleukin-6 Therapeutics in Cardiovascular Disease	234
COVID-19 and Cardiovascular Disease	226
Molecular Basis of Atrial Fibrillation Pathophysiology and Therapy	219
Arterial Stiffness and Cardiovascular Risk in Hypertension	216
Social Determinants of Cardiovascular Disease	210

Meta-Analysis of Leukocyte Diversity in Atherosclerotic Mouse Aortas	202
Epidemiology of Peripheral Artery Disease and Polyvascular Disease	200
Neutrophil Extracellular Traps Participate in Cardiovascular Diseases	197
Post-Stroke Cognitive Impairment and Dementia	194
Sex as a Biological Variable in Atherosclerosis	191
Targeting Mitochondria-Inflammation Circuit by β-Hydroxybutyrate Mitigates HFpEF	189
Oxidative Stress and Hypertension	188
Myofibroblasts and Fibrosis	182
In Situ Expansion, Differentiation, and Electromechanical Coupling of Human Cardiac Muscle in a 3D Bioprinted, Chambered Organoid	172
Adiponectin, Leptin and Cardiovascular Disorders	156
The Impact of Sex and Gender on Stroke	153
Atrial Myocyte NLRP3/CaMKII Nexus Forms a Substrate for Postoperative Atrial Fibrillation	151
GSDMD-Mediated Cardiomyocyte Pyroptosis Promotes Myocardial I/R Injury	143
From Systemic Inflammation to Myocardial Fibrosis	134
Regulatory T Cells License Macrophage Pro-Resolving Functions During Atherosclerosis Regression	128
Clonal Hematopoiesis–Driver DNMT3A Mutations Alter Immune Cells in Heart Failure	127
SIRT6 Protects Smooth Muscle Cells From Senescence and Reduces Atherosclerosis	126
SARS-CoV-2 Initiates Programmed Cell Death in Platelets	125
Celastrol Attenuates Angiotensin II–Induced Cardiac Remodeling by Targeting STAT3	124
Arterial Stiffness Preceding Diabetes	117
Dynamics of Cardiac Neutrophil Diversity in Murine Myocardial Infarction	114
Pathophysiology of Hypertension	113
Intracellular and Intercellular Aspects of Macrophage Immunometabolism in Atherosclerosis	113
Cerebral Hemorrhage: Pathophysiology, Treatment, and Future Directions	111
Pregnancy and Reproductive Risk Factors for Cardiovascular Disease in Women	109
Genetics of Atrial Fibrillation in 2020	109
Hypertension in Low- and Middle-Income Countries	104
Role of the GLUT1 Glucose Transporter in Postnatal CNS Angiogenesis and Blood-Brain Barrier Integrity	102
Reactive Oxygen-Forming Nox5 Links Vascular Smooth Muscle Cell Phenotypic Switching and Extracellular Vesicle-Mediated Vascular Calcification	102
The Tumor-Suppressive Human Circular RNA CircITCH Sponges miR-330-5p to Ameliorate Doxorubicin-Induced Cardiotoxicity Through Upregulating SIRT6, Survivin, and SERCA2a	102
S100A9 Links Inflammation and Repair in Myocardial Infarction	100
NAD ⁺ Repletion Reverses Heart Failure With Preserved Ejection Fraction	96
Polygenic Scores to Assess Atherosclerotic Cardiovascular Disease Risk	96
Hypertension	95
Hematopoiesis and Cardiovascular Disease	95
Inflammation, Infection and Venous Thromboembolism	94
Immune Cells and Immunotherapy for Cardiac Injury and Repair	93
Atherogenic Lipoprotein(a) Increases Vascular Glycolysis, Thereby Facilitating Inflammation and Leukocyte Extravasation	92
Single-Cell Analysis of Blood-Brain Barrier Response to Pericyte Loss	91
Cardiac Resident Macrophages Prevent Fibrosis and Stimulate Angiogenesis	90
BET Epigenetic Reader Proteins in Cardiovascular Transcriptional Programs	88
Lymphatic Malformations: Genetics, Mechanisms and Therapeutic Strategies	87
Molecular Genetic Basis of Hypertrophic Cardiomyopathy	87
Platelet and Vascular Biomarkers Associate With Thrombosis and Death in Coronavirus Disease	86
The Gut Microbiome in Hypertension	85
Genetic Basis and Therapies for Vascular Anomalies	85
Klotho Deficiency Causes Heart Aging via Impairing the Nrf2-GR Pathway	85
miR-128-3p Is a Novel Regulator of Vascular Smooth Muscle Cell Phenotypic Switch and Vascular Diseases	83
Metabolomics and Proteomics in Type 2 Diabetes	83
AP-1 Contributes to Chromatin Accessibility to Promote Sarcomere Disassembly and Cardiomyocyte Protrusion During Zebrafish Heart Regeneration	83

Cerebral Cavernous Malformation: From Mechanism to Therapy	82
Epigenetic Metabolic Reprogramming of Right Ventricular Fibroblasts in Pulmonary Arterial Hypertension	81
Gene Therapy for the Heart Lessons Learned and Future Perspectives	81
Single Cell RNA Sequencing in Atherosclerosis Research	80
Hyperglycemia Acutely Increases Cytosolic Reactive Oxygen Species via O -linked GlcNAcylation and CaMKII Activation in Mouse Ventricular Myocytes	80
A Critical Role for Estrogen-Related Receptor Signaling in Cardiac Maturation	79
tPA Mobilizes Immune Cells That Exacerbate Hemorrhagic Transformation in Stroke	79
New Directions in Therapeutic Angiogenesis and Arteriogenesis in Peripheral Arterial Disease	78
Transient Intermittent Hyperglycemia Accelerates Atherosclerosis by Promoting Myelopoiesis	77
Endothelium-Targeted Deletion of microRNA-15a/16-1 Promotes Poststroke Angiogenesis and Improves Long-Term Neurological Recovery	77
Advances in Revascularization for Peripheral Artery Disease: Revascularization in PAD	77
Noncoding RNAs in Vascular Diseases	77
Animal Models of Atrial Fibrillation	77
Immune Pathways in Etiology, Acute Phase, and Chronic Sequelae of Ischemic Stroke	76
Mir-30d Regulates Cardiac Remodeling by Intracellular and Paracrine Signaling	73
Catecholamines Induce Trained Immunity in Monocytes In Vitro and In Vivo	72
Endothelial S1P ₁ Signaling Counteracts Infarct Expansion in Ischemic Stroke	71
The Calcineurin-TFEB-p62 Pathway Mediates the Activation of Cardiac Macroautophagy by Proteasomal Malfunction	71
Somatic Gain of KRAS Function in the Endothelium Is Sufficient to Cause Vascular Malformations That Require MEK but Not PI3K Signaling	67
Response by Zhang et al to Letter Regarding Article, “Association of Inpatient Use of Angiotensin-Converting Enzyme Inhibitors and Angiotensin II Receptor Blockers With Mortality Among Patients With H	66
Modifiable Cardiovascular Risk, Hematopoiesis, and Innate Immunity	66
Advances in Acute Ischemic Stroke Therapy	64
Single-Cell Epigenomics and Functional Fine-Mapping of Atherosclerosis GWAS Loci	64
Innervation and Neuronal Control of the Mammalian Sinoatrial Node a Comprehensive Atlas	63
Sex Differences in Peripheral Artery Disease	62
Pathophysiology and Therapeutic Approaches to Acute Decompensated Heart Failure	62
Coupling of Integrin α5 to Annexin A2 by Flow Drives Endothelial Activation	61
Iron-Deficiency and Estrogen Are Associated With Ischemic Stroke by Up-Regulating Transferrin to Induce Hypercoagulability	61
Downregulation of LAPTM4B Contributes to the Impairment of the Autophagic Flux via Unopposed Activation of mTORC1 Signaling During Myocardial Ischemia/Reperfusion Injury	61
Racial and Ethnic Disparities in Peripheral Artery Disease	61
Histone Deacetylase 9 Activates IKK to Regulate Atherosclerotic Plaque Vulnerability	61
T-Cell–Derived miRNA-214 Mediates Perivascular Fibrosis in Hypertension	60
JAM-A Acts via C/EBP-α to Promote Claudin-5 Expression and Enhance Endothelial Barrier Function	60
AAV Gene Therapy Prevents and Reverses Heart Failure in a Murine Knockout Model of Barth Syndrome	60
Lgr4 Governs a Pro-Inflammatory Program in Macrophages to Antagonize Post-Infarction Cardiac Repair	60
Genetic Regulation of Atherosclerosis-Relevant Phenotypes in Human Vascular Smooth Muscle Cells	59
Multiscale Analysis of Extracellular Matrix Remodeling in the Failing Heart	59
Gut Microbially Produced Indole-3-Propionic Acid Inhibits Atherosclerosis by Promoting Reverse Cholesterol Transport and Its Deficiency Is Causally Related to Atherosclerotic Cardiovascular Disease	59
Deficient Chaperone-Mediated Autophagy Promotes Inflammation and Atherosclerosis	59
Inflammasomes and Proteostasis Novel Molecular Mechanisms Associated With Atrial Fibrillation	59
Hypoalbuminemia, Coagulopathy, and Vascular Disease in COVID-19	58
Hypertension, a Moving Target in COVID-19	58
KLF5 Is Induced by FOXO1 and Causes Oxidative Stress and Diabetic Cardiomyopathy	57
Genetics Insights in the Relationship Between Type 2 Diabetes and Coronary Heart Disease	57
Pathophysiology and Therapeutic Approaches to Cardiac Amyloidosis	56
RYR2 Channel Inhibition Is the Principal Mechanism of Flecainide Action in CPVT	56
Hypertension and Prohypertensive Antineoplastic Therapies in Cancer Patients	56
Deletion of BACH1 Attenuates Atherosclerosis by Reducing Endothelial Inflammation	56
Leveraging Machine Learning and Artificial Intelligence to Improve Peripheral Artery Disease Detection, Treatment, and Outcomes	54
Population-Based Screening for Atrial Fibrillation	54
Extreme Acetylation of the Cardiac Mitochondrial Proteome Does Not Promote Heart Failure	54
A Computational Pipeline to Predict Cardiotoxicity	53
Sex Differences in Myocardial and Vascular Aging	53
Contemporary Medical Management of Peripheral Artery Disease	53
Epigenetic Age Acceleration Reflects Long-Term Cardiovascular Health	53
Nonalcoholic Fatty Liver Disease: An Emerging Driver of Cardiac Arrhythmia	52
CD84 Links T Cell and Platelet Activity in Cerebral Thrombo-Inflammation in Acute Stroke	52
Histone Lactylation Boosts Reparative Gene Activation Post–Myocardial Infarction	52
Guideline-Driven Management of Hypertension	52
Endothelial Cell Receptors in Tissue Lipid Uptake and Metabolism	51
Emerging Technologies for Identifying Atrial Fibrillation	50
Glutamyl-Prolyl-tRNA Synthetase Regulates Proline-Rich Pro-Fibrotic Protein Synthesis During Cardiac Fibrosis	50
Vaccination Strategies and Immune Modulation of Atherosclerosis	49
Inflammation Resolution: Implications for Atherosclerosis	49
The Complex and Diverse Genetic Architecture of Dilated Cardiomyopathy	48
Alternative Mitophagy Protects the Heart Against Obesity-Associated Cardiomyopathy	48
Mechanisms of Cardiovascular Toxicities Associated With Immunotherapies	48
Platelet and Megakaryocyte Roles in Innate and Adaptive Immunity	48
Unveiling Complexity and Multipotentiality of Early Heart Fields	48
CARMN Loss Regulates Smooth Muscle Cells and Accelerates Atherosclerosis in Mice	47
The Super-Relaxed State and Length Dependent Activation in Porcine Myocardium	47
SARS-CoV-2 Infection Induces Ferroptosis of Sinoatrial Node Pacemaker Cells	47
Emerging Technologies for Pulmonary Vein Isolation	47
Machine Learning in Arrhythmia and Electrophysiology	47
The Molecular Basis of Predicting Atherosclerotic Cardiovascular Disease Risk	46
LDL-Cholesterol Reduction by ANGPTL3 Inhibition in Mice Is Dependent on Endothelial Lipase	46
Metabolic and Molecular Imaging of the Diabetic Cardiomyopathy	46
Piezo1 Is a Mechanosensor Channel in Central Nervous System Capillaries	46
MCU Overexpression Rescues Inotropy and Reverses Heart Failure by Reducing SR Ca ²⁺ Leak	46
CircOGDH Is a Penumbra Biomarker and Therapeutic Target in Acute Ischemic Stroke	45

Restructuring the Gut Microbiota by Intermittent Fasting Lowers Blood Pressure	45
Interaction of the Joining Region in Junctophilin-2 With the L-Type Ca ²⁺ Channel Is Pivotal for Cardiac Dyad Assembly and Intracellular Ca ²⁺	45
CD31 as a Therapeutic Target in Atherosclerosis	45
Epigenetic and Transcriptional Networks Underlying Atrial Fibrillation	45
Gut Microbiome and Neuroinflammation in Hypertension	45
Reactivation of the Epicardium at the Origin of Myocardial Fibro-Fatty Infiltration During the Atrial Cardiomyopathy	45
Self-Maintenance of Cardiac Resident Reparative Macrophages Attenuates Doxorubicin-Induced Cardiomyopathy Through the SR-A1-c-Myc Axis	44
Disrupted Resolution Mechanisms Favor Altered Phagocyte Responses in COVID-19	44
LDL Receptor Regulates the Reverse Transport of Macrophage-Derived Unesterified Cholesterol via Concerted Action of the HDL-LDL Axis	44
Leukocyte Heterogeneity in Adipose Tissue, Including in Obesity	43
Small Extracellular Vesicles From Brown Adipose Tissue Mediate Exercise Cardioprotection	43
Heart Failure With Preserved Ejection Fraction: Heterogeneous Syndrome, Diverse Preclinical Models	43
Sex Differences and Similarities in Valvular Heart Disease	43
EHD1 Modulates Cx43 Gap Junction Remodeling Associated With Cardiac Diseases	42
The Cancer Therapy-Related Clonal Hematopoiesis Driver Gene Ppm1d Promotes Inflammation and Non-Ischemic Heart Failure in Mice	42
Gut Dysbiosis Promotes Preeclampsia by Regulating Macrophages and Trophoblasts	42
Erythrocyte Metabolic Reprogramming by Sphingosine 1-Phosphate in Chronic Kidney Disease and Therapies	42
PPARγ-p53-Mediated Vasculoregenerative Program to Reverse Pulmonary Hypertension	41
Cardiac Tissues From Stem Cells	41
Aging Microbiota-Gut-Brain Axis in Stroke Risk and Outcome	41
Diabetes Impairs Cellular Cholesterol Efflux From ABCA1 to Small HDL Particles	41
MIR503HG Loss Promotes Endothelial-to-Mesenchymal Transition in Vascular Disease	40
Infarct Collagen Topography Regulates Fibroblast Fate via p38-Yes-Associated Protein Transcriptional Enhanced Associate Domain Signals	40
A Neuroligin Isoform Translated by circNlgn Contributes to Cardiac Remodeling	40
An Immuno-Cardiac Model for Macrophage-Mediated Inflammation in COVID-19 Hearts	39
Live Imaging of Intracranial Lymphatics in the Zebrafish	39
Advances in Lymphedema	39
Lipid Profiles and Heart Failure Risk	39
Brain Hypoxia Is Associated With Neuroglial Injury in Humans Post–Cardiac Arrest	38
CaMKII Serine 280 O-GlcNAcylation Links Diabetic Hyperglycemia to Proarrhythmia	38
Hyperglycemia Induces Myocardial Dysfunction via Epigenetic Regulation of JunD	38
Multi-Omics Approaches to Define Calcific Aortic Valve Disease Pathogenesis	38
Intracellular β ₁ -Adrenergic Receptors and Organic Cation Transporter 3 Mediate Phospholamban Phosphorylation to Enhance Cardiac Contractility	38
Exercise Regulates MicroRNAs to Preserve Coronary and Cardiac Function in the Diabetic Heart	37
Reverse Remodeling With Left Ventricular Assist Devices	37
Immunometabolic Endothelial Phenotypes: Integrating Inflammation and Glucose Metabolism	37
Targeting CaMKII-δ9 Ameliorates Cardiac Ischemia/Reperfusion Injury by Inhibiting Myocardial Inflammation	37
Illuminating the Mechanisms Underlying Sex Differences in Cardiovascular Disease	37
Adrenergic Ca _V 1.2 Activation via Rad Phosphorylation Converges at α _1C I-II Loop	37
Vascular Dysfunction of COVID-19 Is Partially Reverted in the Long-Term	37
COVID-19, Myocarditis and Pericarditis	36
MCUb Induction Protects the Heart From Postischemic Remodeling	36
Modulation of Mammalian Cardiomyocyte Cytokinesis by the Extracellular Matrix	35
Association Between Atrial Fibrillation and Sudden Cardiac Death	35
Treatment of Obesity in Mitigating Metabolic Risk	35
Preclinical Models of Cancer Therapy–Associated Cardiovascular Toxicity: A Scientific Statement From the American Heart Association	35
Tamoxifen-Activated CreERT Impairs Retinal Angiogenesis Independently of Gene Deletion	35
Nutrition, Thrombosis, and Cardiovascular Disease	35
The Latest in Animal Models of Pulmonary Hypertension and Right Ventricular Failure	35
Machine Learned Cellular Phenotypes in Cardiomyopathy Predict Sudden Death	35
Faecalibacterium prausnitzii Attenuates CKD via Butyrate-Renal GPR43 Axis	34
Platelets and COVID-19	34
How Will Machine Learning Inform the Clinical Care of Atrial Fibrillation?	34
Myeloid Cell PKM2 Deletion Enhances Efferocytosis and Reduces Atherosclerosis	34
ATAC-Seq Reveals an Isl1 Enhancer That Regulates Sinoatrial Node Development and Function	34
atg7 -Based Autophagy Activation Reverses Doxorubicin-Induced Cardiotoxicity	34
Reduced Platelet miR-223 Induction in Kawasaki Disease Leads to Severe Coronary Artery Pathology Through a miR-223/PDGFRβ Vascular Smooth Muscle Cell Axis	34
Generation of Vascular Smooth Muscle Cells From Induced Pluripotent Stem Cells	34
Novel Methods for Quantification of Vasodepression and Cardioinhibition During Tilt-Induced Vasovagal Syncope	34
Association of Habitual Physical Activity With Cardiovascular Disease Risk	34
Gut Microbiota-Associated Activation of TLR5 Induces Apolipoprotein A1 Production in the Liver	33
GLP1R Attenuates Sympathetic Response to High Glucose via Carotid Body Inhibition	33
Periostin	33
Eosinophils Protect Mice From Angiotensin-II Perfusion–Induced Abdominal Aortic Aneurysm	33
Somatic Mutations in Cardiovascular Disease	32
CRISPR Modeling and Correction of Cardiovascular Disease	32
Heart Failure With Targeted Cancer Therapies	32
Sorting Nexin 10 Mediates Metabolic Reprogramming of Macrophages in Atherosclerosis Through the Lyn-Dependent TFEB Signaling Pathway	32
Randomized Trial of Etelcalcetide for Cardiac Hypertrophy in Hemodialysis	32
DC ENaC-Dependent Inflammasome Activation Contributes to Salt-Sensitive Hypertension	32
Effects of Atrial Fibrillation on the Human Ventricle	32
Loss of Hepatic Angiotensinogen Attenuates Sepsis-Induced Myocardial Dysfunction	32
Genetic Dissection of a Super Enhancer Controlling the Nppa-Nppb Cluster in the Heart	32
Device Therapy of Hypertension	32
CaMKIIδC Drives Early Adaptive Ca ²⁺ Change and Late Eccentric Cardiac Hypertrophy	31
Autophagy Is Differentially Regulated in Leukocyte and Nonleukocyte Foam Cells During Atherosclerosis	31
Inflammatory and Biomechanical Drivers of Endothelial-Interstitial Interactions in Calcific Aortic Valve Disease	31
Butyrate-Rich Diets Improve Redox Status and Fibrin Lysis in Behçet’s Syndrome	31
Yap Promotes Noncanonical Wnt Signals From Cardiomyocytes for Heart Regeneration	31
Identification of Functional Variant Enhancers Associated With Atrial Fibrillation	31
Novel Mechanisms of Exosome-Mediated Phagocytosis of Dead Cells in Injured Heart	30
Mitochondrial H ₂ S Regulates BCAA Catabolism in Heart Failure	30
CalTrack: High-Throughput Automated Calcium Transient Analysis in Cardiomyocytes	30
NLRP3 Inflammasome Mediates Immune-Stromal Interactions in Vasculitis	30
Ischemia-Selective Cardioprotection by Malonate for Ischemia/Reperfusion Injury	30
Sex-Specific Cardiovascular Risks of Cancer and Its Therapies	29
Inactivation of ApoC3 by CRISPR/Cas9 Protects Against Atherosclerosis in Hamsters	29
Niacin Attenuates Pulmonary Hypertension Through H-PGDS in Macrophages	29
Epigenomes of Human Hearts Reveal New Genetic Variants Relevant for Cardiac Disease and Phenotype	29
Coronary Arterial Function and Disease in Women With No Obstructive Coronary Arteries	29
Cardiovascular Disease Screening in Women: Leveraging Artificial Intelligence and Digital Tools	29
Targeting Myeloid-Specific Integrin α9β1 Improves Short- and Long-Term Stroke Outcomes in Murine Models With Preexisting Comorbidities by Limiting Thrombosis and Inflammation	29
PKG1α Cysteine-42 Redox State Controls mTORC1 Activation in Pathological Cardiac Hypertrophy	28
Activation of Autophagic Flux Blunts Cardiac Ischemia/Reperfusion Injury	28
Cellular and Engineered Organoids for Cardiovascular Models	28