OOIR: Observatory of International Research

Papers

(The median citation count of Circulation is 0. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-07-01 to 2024-07-01.)

Article	Citations
Heart Disease and Stroke Statistics—2021 Update	3502
Heart Disease and Stroke Statistics—2022 Update: A Report From the American Heart Association	2849
Heart Disease and Stroke Statistics—2023 Update: A Report From the American Heart Association	1337
Obesity and Cardiovascular Disease: A Scientific Statement From the American Heart Association	1064
Part 3: Adult Basic and Advanced Life Support: 2020 American Heart Association Guidelines for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care	869
Pulmonary Embolism in Patients With COVID-19	867
Acute Heart Failure in Multisystem Inflammatory Syndrome in Children in the Context of Global SARS-CoV-2 Pandemic	853
Cardiovascular Disease in Chronic Kidney Disease	776
Life’s Essential 8: Updating and Enhancing the American Heart Association’s Construct of Cardiovascular Health: A Presidential Advisory From the American Heart Association	705
2022 AHA/ACC/HFSA Guideline for the Management of Heart Failure: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines	702
The Science Underlying COVID-19	627
Myocarditis With COVID-19 mRNA Vaccines	626
Call to Action: Structural Racism as a Fundamental Driver of Health Disparities: A Presidential Advisory From the American Heart Association	586
2020 ACC/AHA Guideline for the Management of Patients With Valvular Heart Disease: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidel	558
Obesity Is a Risk Factor for Severe COVID-19 Infection	546
2022 ACC/AHA Guideline for the Diagnosis and Management of Aortic Disease: A Report of the American Heart Association/American College of Cardiology Joint Committee on Clinical Practice Guidelines	443
Spectrum of Cardiac Manifestations in COVID-19	441
2021 Dietary Guidance to Improve Cardiovascular Health: A Scientific Statement From the American Heart Association	436
Immunothrombotic Dysregulation in COVID-19 Pneumonia Is Associated With Respiratory Failure and Coagulopathy	428
Part 1: Executive Summary: 2020 American Heart Association Guidelines for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care	410
Menopause Transition and Cardiovascular Disease Risk: Implications for Timing of Early Prevention: A Scientific Statement From the American Heart Association	379
2020 ACC/AHA Guideline for the Management of Patients With Valvular Heart Disease: Executive Summary: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clini	354
Transcriptional and Cellular Diversity of the Human Heart	340
Single-Cell Genomics Reveals a Novel Cell State During Smooth Muscle Cell Phenotypic Switching and Potential Therapeutic Targets for Atherosclerosis in Mouse and Human	334
Adverse Pregnancy Outcomes and Cardiovascular Disease Risk: Unique Opportunities for Cardiovascular Disease Prevention in Women: A Scientific Statement From the American Heart Association	306

Association Between Immune Checkpoint Inhibitors With Cardiovascular Events and Atherosclerotic Plaque	303
Deep Vein Thrombosis in Hospitalized Patients With COVID-19 in Wuhan, China	301
Lower Extremity Peripheral Artery Disease: Contemporary Epidemiology, Management Gaps, and Future Directions: A Scientific Statement From the American Heart Association	286
Left Ventricular Unloading Is Associated With Lower Mortality in Patients With Cardiogenic Shock Treated With Venoarterial Extracorporeal Membrane Oxygenation	283
Psychological Health, Well-Being, and the Mind-Heart-Body Connection: A Scientific Statement From the American Heart Association	278
Empagliflozin in Heart Failure	263
Ablation Versus Drug Therapy for Atrial Fibrillation in Heart Failure	259
Cardiorespiratory Fitness in Youth: An Important Marker of Health: A Scientific Statement From the American Heart Association	253
Effect of Empagliflozin on Left Ventricular Volumes in Patients With Type 2 Diabetes, or Prediabetes, and Heart Failure With Reduced Ejection Fraction (SUGAR-DM-HF)	248
Carotid Intima-Media Thickness Progression as Surrogate Marker for Cardiovascular Risk	242
Part 4: Pediatric Basic and Advanced Life Support: 2020 American Heart Association Guidelines for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care	241
Stem Cell Pluripotency Genes Klf4 and Oct4 Regulate Complex SMC Phenotypic Changes Critical in Late-Stage Atherosclerotic Lesion Pathogenesis	235
Effect of Empagliflozin on the Clinical Stability of Patients With Heart Failure and a Reduced Ejection Fraction	234
Acute Cardiovascular Manifestations in 286 Children With Multisystem Inflammatory Syndrome Associated With COVID-19 Infection in Europe	232
Association of Body Mass Index and Age With Morbidity and Mortality in Patients Hospitalized With COVID-19	231
Comprehensive Management of Cardiovascular Risk Factors for Adults With Type 2 Diabetes: A Scientific Statement From the American Heart Association	231
Primary Outcome Evaluation of a Next-Generation Left Atrial Appendage Closure Device	224
Effect of Empagliflozin on Cardiovascular and Renal Outcomes in Patients With Heart Failure by Baseline Diabetes Status	224
Review of Cardiac Involvement in Multisystem Inflammatory Syndrome in Children	218
Effect of Empagliflozin on Worsening Heart Failure Events in Patients With Heart Failure and Preserved Ejection Fraction: EMPEROR-Preserved Trial	208
Extracellular Vesicle–Mediated Delivery of Circular RNA SCMH1 Promotes Functional Recovery in Rodent and Nonhuman Primate Ischemic Stroke Models	207
Integrated Single-Cell Atlas of Endothelial Cells of the Human Lung	206
Angiotensin Converting Enzyme 2	204
Amplatzer Amulet Left Atrial Appendage Occluder Versus Watchman Device for Stroke Prophylaxis (Amulet IDE): A Randomized, Controlled Trial	201
Colchicine in Patients With Acute Coronary Syndrome	201
Self-Measured Blood Pressure Monitoring at Home: A Joint Policy Statement From the American Heart Association and American Medical Association	199
Severe COVID-19 Is a Microvascular Disease	199
Efficacy of Dapagliflozin on Renal Function and Outcomes in Patients With Heart Failure With Reduced Ejection Fraction	199
Fruit and Vegetable Intake and Mortality	196
COVID-19, Arrhythmic Risk, and Inflammation	195
SARS-CoV-2 Cardiac Involvement in Young Competitive Athletes	195
Effects of n-3 Fatty Acid Supplements in Elderly Patients After Myocardial Infarction	189
Telemedicine Outpatient Cardiovascular Care During the COVID-19 Pandemic	187
Emulating Randomized Clinical Trials With Nonrandomized Real-World Evidence Studies	181
Prevalence of Subclinical Coronary Artery Atherosclerosis in the General Population	181
Neonatal Life Support: 2020 International Consensus on Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Science With Treatment Recommendations	180
Cardiac and Kidney Benefits of Empagliflozin in Heart Failure Across the Spectrum of Kidney Function	180
Part 5: Neonatal Resuscitation: 2020 American Heart Association Guidelines for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care	180
Finerenone and Cardiovascular Outcomes in Patients With Chronic Kidney Disease and Type 2 Diabetes	178
2021 AHA/ACC/ASE/CHEST/SAEM/SCCT/SCMR Guideline for the Evaluation and Diagnosis of Chest Pain: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Pr	178
Acute COVID-19 and the Incidence of Ischemic Stroke and Acute Myocardial Infarction	174
Coronary Optical Coherence Tomography and Cardiac Magnetic Resonance Imaging to Determine Underlying Causes of Myocardial Infarction With Nonobstructive Coronary Arteries in Women	171
Extremely High Incidence of Lower Extremity Deep Venous Thrombosis in 48 Patients With Severe COVID-19 in Wuhan	171
Myocarditis After BNT162b2 and mRNA-1273 Vaccination	168
Myocarditis Temporally Associated With COVID-19 Vaccination	167
2023 AHA/ACC/ACCP/ASPC/NLA/PCNA Guideline for the Management of Patients With Chronic Coronary Disease: A Report of the American Heart Association/American College of Cardiology Joint Committee on Cli	166
Single-Cell RNA Sequencing Unveils Unique Transcriptomic Signatures of Organ-Specific Endothelial Cells	165
High-Resolution Transcriptomic Profiling of the Heart During Chronic Stress Reveals Cellular Drivers of Cardiac Fibrosis and Hypertrophy	165
Single-Cell Transcriptome Analysis Reveals Dynamic Cell Populations and Differential Gene Expression Patterns in Control and Aneurysmal Human Aortic Tissue	162
Efficacy of Ertugliflozin on Heart Failure–Related Events in Patients With Type 2 Diabetes Mellitus and Established Atherosclerotic Cardiovascular Disease	161

Nighttime Blood Pressure Phenotype and Cardiovascular Prognosis	160
Status of Cardiovascular Health in US Adults and Children Using the American Heart Association’s New “Life’s Essential 8” Metrics: Prevalence Estimates From the National Health and Nutrition Examinati	159
How Should We Sequence the Treatments for Heart Failure and a Reduced Ejection Fraction?	157
2020 AHA/ACC Guideline for the Diagnosis and Treatment of Patients With Hypertrophic Cardiomyopathy	155
Drug-Induced Arrhythmias: A Scientific Statement From the American Heart Association	153
2021 ACC/AHA/SCAI Guideline for Coronary Artery Revascularization: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines	153
Critical Reanalysis of the Mechanisms Underlying the Cardiorenal Benefits of SGLT2 Inhibitors and Reaffirmation of the Nutrient Deprivation Signaling/Autophagy Hypothesis	151
Diagnosis and Management of Myocarditis in Children	151
Extracorporeal Membrane Oxygenation in the Therapy of Cardiogenic Shock: Results of the ECMO-CS Randomized Clinical Trial	151
2021 ACC/AHA/SCAI Guideline for Coronary Artery Revascularization: Executive Summary: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Gui	151
Renal and Cardiovascular Effects of SGLT2 Inhibition in Combination With Loop Diuretics in Patients With Type 2 Diabetes and Chronic Heart Failure	150
Long-Term Evolocumab in Patients With Established Atherosclerotic Cardiovascular Disease	150
Fate and State of Vascular Smooth Muscle Cells in Atherosclerosis	149
Correction to: 2022 AHA/ACC/HFSA Guideline for the Management of Heart Failure: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guideline	147
Blood Pressure Effects of Sodium Reduction	147
Direct Oral Anticoagulants Versus Warfarin in Patients With Atrial Fibrillation: Patient-Level Network Meta-Analyses of Randomized Clinical Trials With Interaction Testing by Age and Sex	146
Single-Cell RNA Sequencing Analysis Reveals a Crucial Role for CTHRC1 (Collagen Triple Helix Repeat Containing 1) Cardiac Fibroblasts After Myocardial Infarction	146
Mechanical Complications of Acute Myocardial Infarction: A Scientific Statement From the American Heart Association	146
Outcomes in the ISCHEMIA Trial Based on Coronary Artery Disease and Ischemia Severity	145
HDL in the 21st Century: A Multifunctional Roadmap for Future HDL Research	144
Cell-Free DNA to Detect Heart Allograft Acute Rejection	143
Definitions and Clinical Trial Design Principles for Coronary Artery Chronic Total Occlusion Therapies: CTO-ARC Consensus Recommendations	142
2022 AHA/ACC/HFSA Guideline for the Management of Heart Failure: Executive Summary: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guide	141
Association of COVID-19 With Major Arterial and Venous Thrombotic Diseases: A Population-Wide Cohort Study of 48 Million Adults in England and Wales	141
Ibrutinib-Mediated Atrial Fibrillation Attributable to Inhibition of C-Terminal Src Kinase	140
COVID-19 Myocardial Pathology Evaluation in Athletes With Cardiac Magnetic Resonance (COMPETE CMR)	140
Unexpected Features of Cardiac Pathology in COVID-19 Infection	136
A Validated Model for Sudden Cardiac Death Risk Prediction in Pediatric Hypertrophic Cardiomyopathy	136
Aortic Valve Replacement Versus Conservative Treatment in Asymptomatic Severe Aortic Stenosis: The AVATAR Trial	133
Influenza Vaccination After Myocardial Infarction: A Randomized, Double-Blind, Placebo-Controlled, Multicenter Trial	133
Sex Differences in Blood Pressure Associations With Cardiovascular Outcomes	129
Prevention of Viridans Group Streptococcal Infective Endocarditis: A Scientific Statement From the American Heart Association	129
Myocardial Gene Expression Signatures in Human Heart Failure With Preserved Ejection Fraction	129
Pulsed Field Ablation for the Treatment of Atrial Fibrillation: PULSED AF Pivotal Trial	128
Dapagliflozin and Diuretic Use in Patients With Heart Failure and Reduced Ejection Fraction in DAPA-HF	128
Ten-Year Differences in Women’s Awareness Related to Coronary Heart Disease: Results of the 2019 American Heart Association National Survey: A Special Report From the American Heart Association	128
COVID-19–Associated Nonocclusive Fibrin Microthrombi in the Heart	128
Primary Results From the Understanding Outcomes With the S-ICD in Primary Prevention Patients With Low Ejection Fraction (UNTOUCHED) Trial	127
Proteomic Evaluation of the Comorbidity-Inflammation Paradigm in Heart Failure With Preserved Ejection Fraction	127
Fontan-Associated Liver Disease	127
Antithrombotic Therapy in Patients With Atrial Fibrillation Treated With Oral Anticoagulation Undergoing Percutaneous Coronary Intervention	126
Prevalence, Characteristics, and Outcomes of COVID-19–Associated Acute Myocarditis	126
PCSK9 (Proprotein Convertase Subtilisin/Kexin 9) Enhances Platelet Activation, Thrombosis, and Myocardial Infarct Expansion by Binding to Platelet CD36	125
Assessing and Addressing Cardiovascular Health in LGBTQ Adults: A Scientific Statement From the American Heart Association	124
Hyperglycemia Induces Trained Immunity in Macrophages and Their Precursors and Promotes Atherosclerosis	124
ECG-Based Deep Learning and Clinical Risk Factors to Predict Atrial Fibrillation	123
COVID-19	122
Early Rhythm Control Therapy in Patients With Atrial Fibrillation and Heart Failure	121
Cardiac Late Sodium Channel Current Is a Molecular Target for the Sodium/Glucose Cotransporter 2 Inhibitor Empagliflozin	120
Altered Hemodynamics and End-Organ Damage in Heart Failure	120
Routine Revascularization Versus Initial Medical Therapy for Stable Ischemic Heart Disease	120
Health-Related Quality of Life and Mortality in Heart Failure: The Global Congestive Heart Failure Study of 23 000 Patients From 40 Countries	120
Risk of Myocarditis After Sequential Doses of COVID-19 Vaccine and SARS-CoV-2 Infection by Age and Sex	119
Endotoxinemia Accelerates Atherosclerosis Through Electrostatic Charge–Mediated Monocyte Adhesion	119
Differentiating COVID-19 Pneumonia From Acute Respiratory Distress Syndrome and High Altitude Pulmonary Edema	119
Takotsubo Syndrome: Pathophysiology, Emerging Concepts, and Clinical Implications	119
Medical Marijuana, Recreational Cannabis, and Cardiovascular Health: A Scientific Statement From the American Heart Association	117
US Mortality Attributable to Congenital Heart Disease Across the Lifespan From 1999 Through 2017 Exposes Persistent Racial/Ethnic Disparities	117
Assessing and Addressing Cardiovascular Health in People Who Are Transgender and Gender Diverse: A Scientific Statement From the American Heart Association	117
Sodium-Glucose Cotransporter 2 Inhibitors and Risk of Hyperkalemia in People With Type 2 Diabetes: A Meta-Analysis of Individual Participant Data From Randomized, Controlled Trials	116
A Unique Population of Regulatory T Cells in Heart Potentiates Cardiac Protection From Myocardial Infarction	116
Mavacamten Favorably Impacts Cardiac Structure in Obstructive Hypertrophic Cardiomyopathy	115
Invasive Management of Acute Myocardial Infarction Complicated by Cardiogenic Shock: A Scientific Statement From the American Heart Association	115
Prospective Multicenter Study of Myocardial Recovery Using Left Ventricular Assist Devices (RESTAGE-HF [Remission from Stage D Heart Failure])	114
Dual Antiplatelet Therapy After Percutaneous Coronary Intervention and Drug-Eluting Stents	114
Empagliflozin, Health Status, and Quality of Life in Patients With Heart Failure and Preserved Ejection Fraction: The EMPEROR-Preserved Trial	114
Racial and Ethnic Differences in Presentation and Outcomes for Patients Hospitalized With COVID-19: Findings From the American Heart Association’s COVID-19 Cardiovascular Disease Registry	113
Extracellular Vesicles From Epicardial Fat Facilitate Atrial Fibrillation	111
Cardiorenal Protection With the Newer Antidiabetic Agents in Patients With Diabetes and Chronic Kidney Disease: A Scientific Statement From the American Heart Association	111
Altered Cardiac Energetics and Mitochondrial Dysfunction in Hypertrophic Cardiomyopathy	109
Increasing Fatty Acid Oxidation Prevents High-Fat Diet–Induced Cardiomyopathy Through Regulating Parkin-Mediated Mitophagy	109
RIPK1 Expression Associates With Inflammation in Early Atherosclerosis in Humans and Can Be Therapeutically Silenced to Reduce NF-κB Activation and Atherogenesis in Mice	107
Guidance for Timely and Appropriate Referral of Patients With Advanced Heart Failure: A Scientific Statement From the American Heart Association	106
Diagnosis and Management of Patients With Myocardial Injury After Noncardiac Surgery: A Scientific Statement From the American Heart Association	105
Bariatric Surgery and Cardiovascular Outcomes in Patients With Obesity and Cardiovascular Disease:	105
Single-Cell RNA Sequencing to Dissect the Immunological Network of Autoimmune Myocarditis	104
2020 AHA/ACC Guideline for the Diagnosis and Treatment of Patients With Hypertrophic Cardiomyopathy: Executive Summary	104
Effect of the Glucagon-Like Peptide-1 Receptor Agonists Semaglutide and Liraglutide on Kidney Outcomes in Patients With Type 2 Diabetes: Pooled Analysis of SUSTAIN 6 and LEADER	103
Systemic Inflammatory Response Syndrome Is a Major Contributor to COVID-19–Associated Coagulopathy	103
Part 6: Resuscitation Education Science: 2020 American Heart Association Guidelines for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care	103

Detection of Atrial Fibrillation in a Large Population Using Wearable Devices: The Fitbit Heart Study	103
Transcatheter Aortic Valve Replacement in Bicuspid Aortic Valve Stenosis	102
Pathogenic Autoimmunity in Atherosclerosis Evolves From Initially Protective Apolipoprotein B ₁₀₀ –Reactive CD4 ⁺ T-Regulatory Cel	102
Myocardial Injury in Severe COVID-19 Compared With Non–COVID-19 Acute Respiratory Distress Syndrome	102
Randomized Pilot Clinical Trial of Early Coronary Angiography Versus No Early Coronary Angiography After Cardiac Arrest Without ST-Segment Elevation	101
Finerenone Reduces Risk of Incident Heart Failure in Patients With Chronic Kidney Disease and Type 2 Diabetes: Analyses From the FIGARO-DKD Trial	100
Effect of Vupanorsen on Non–High-Density Lipoprotein Cholesterol Levels in Statin-Treated Patients With Elevated Cholesterol: TRANSLATE-TIMI 70	100
Identification of Long Noncoding RNA H19 as a New Biomarker and Therapeutic Target in Right Ventricular Failure in Pulmonary Arterial Hypertension	99
Part 7: Systems of Care: 2020 American Heart Association Guidelines for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care	97
Heart Regeneration by Endogenous Stem Cells and Cardiomyocyte Proliferation	97
Polygenic Risk Scores for Cardiovascular Disease: A Scientific Statement From the American Heart Association	96
Long Noncoding RNA MIAT Controls Advanced Atherosclerotic Lesion Formation and Plaque Destabilization	96
Rise in Blood Pressure Observed Among US Adults During the COVID-19 Pandemic	95
gp130 Controls Cardiomyocyte Proliferation and Heart Regeneration	95
Red Blood Cell and Endothelial eNOS Independently Regulate Circulating Nitric Oxide Metabolites and Blood Pressure	95
Coronary Artery Anomalies	94
Circulating Spike Protein Detected in Post–COVID-19 mRNA Vaccine Myocarditis	94
An Electronically Delivered Patient-Activation Tool for Intensification of Medications for Chronic Heart Failure With Reduced Ejection Fraction	93
In-Depth Evaluation of a Case of Presumed Myocarditis After the Second Dose of COVID-19 mRNA Vaccine	93
High-Sensitivity Cardiac Troponin on Presentation to Rule Out Myocardial Infarction: A Stepped-Wedge Cluster Randomized Controlled Trial	92
The Safety and Efficacy of Aspirin Discontinuation on a Background of a P2Y ₁₂ Inhibitor in Patients After Percutaneous Coronary Intervention	92
Transcatheter Mitral Valve Replacement After Surgical Repair or Replacement	91
The COMPASS Trial	91
Management of Patients at Risk for and With Left Ventricular Thrombus: A Scientific Statement From the American Heart Association	90
Angiotensin-Neprilysin Inhibition and Renal Outcomes in Heart Failure With Preserved Ejection Fraction	90
Comparative Efficacy and Safety of Oral P2Y ₁₂ Inhibitors in Acute Coronary Syndrome	90
GLP-1 Receptor Agonists for the Reduction of Atherosclerotic Cardiovascular Risk in Patients With Type 2 Diabetes	89
Premature Menopause, Clonal Hematopoiesis, and Coronary Artery Disease in Postmenopausal Women	89
Myocardial Infarction in the ISCHEMIA Trial	88
Prevalence of Infective Endocarditis in Streptococcal Bloodstream Infections Is Dependent on Streptococcal Species	87
General Versus Local Anesthesia With Conscious Sedation in Transcatheter Aortic Valve Implantation	87
Artificial Intelligence–Enabled Assessment of the Heart Rate Corrected QT Interval Using a Mobile Electrocardiogram Device	86
2024 Heart Disease and Stroke Statistics: A Report of US and Global Data From the American Heart Association	86
Replacement Myocardial Fibrosis in Patients With Mitral Valve Prolapse	86
Associations Between Extreme Temperatures and Cardiovascular Cause-Specific Mortality: Results From 27 Countries	86
Does Timing of Ventricular Tachycardia Ablation Affect Prognosis in Patients With an Implantable Cardioverter Defibrillator? Results From the Multicenter Randomized PARTITA Trial	86
Adult Basic Life Support: 2020 International Consensus on Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Science With Treatment Recommendations	86
Effects of Early Empagliflozin Initiation on Diuresis and Kidney Function in Patients With Acute Decompensated Heart Failure (EMPAG-HF)	86
Growth Differentiation Factor 15 Provides Prognostic Information Superior to Established Cardiovascular and Inflammatory Biomarkers in Unselected Patients Hospitalized With COVID-19	86
Sarcopenia and Cardiovascular Diseases	85
A Novel Endocrine Role for the BAT-Released Lipokine 12,13-diHOME to Mediate Cardiac Function	85
Effect of Dapagliflozin on Clinical Outcomes in Patients With Chronic Kidney Disease, With and Without Cardiovascular Disease	85
Medium- and Large-Vessel Vasculitis	84
Cardiac Resident Macrophage-Derived Legumain Improves Cardiac Repair by Promoting Clearance and Degradation of Apoptotic Cardiomyocytes After Myocardial Infarction	84
Transethnic Genome-Wide Association Study Provides Insights in the Genetic Architecture and Heritability of Long QT Syndrome	84
Cardiovascular Safety of Degarelix Versus Leuprolide in Patients With Prostate Cancer: The Primary Results of the PRONOUNCE Randomized Trial	84
Social Vulnerability and Premature Cardiovascular Mortality Among US Counties, 2014 to 2018	83
Saphenous Vein Graft Failure: From Pathophysiology to Prevention and Treatment Strategies	83
Cardiovascular-Kidney-Metabolic Health: A Presidential Advisory From the American Heart Association	83
Association of Blood Pressure Classification Using the 2017 American College of Cardiology/American Heart Association Blood Pressure Guideline With Risk of Heart Failure and Atrial Fibrillation	82
Quantifying and Understanding the Higher Risk of Atherosclerotic Cardiovascular Disease Among South Asian Individuals	82
Colchicine Attenuates Inflammation Beyond the Inflammasome in Chronic Coronary Artery Disease	82
Role of Venous Endothelial Cells in Developmental and Pathologic Angiogenesis	81
Effect of Colchicine on Myocardial Injury in Acute Myocardial Infarction	81
Neutrophils and Contact Activation of Coagulation as Potential Drivers of COVID-19	81
Long-Term Association of Air Pollution and Hospital Admissions Among Medicare Participants Using a Doubly Robust Additive Model	80
Contemporary Diagnosis and Management of Rheumatic Heart Disease: Implications for Closing the Gap: A Scientific Statement From the American Heart Association	80
2021 AHA/ACC/ASE/CHEST/SAEM/SCCT/SCMR Guideline for the Evaluation and Diagnosis of Chest Pain: Executive Summary: A Report of the American College of Cardiology/American Heart Association Joint Commi	80
Adult Advanced Life Support: 2020 International Consensus on Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Science With Treatment Recommendations	80
Genetic Architecture of Abdominal Aortic Aneurysm in the Million Veteran Program	80
Efficacy and Safety of an Investigational Single-Course CRISPR Base-Editing Therapy Targeting PCSK9 in Nonhuman Primate and Mouse Models	79
At the Heart of the Matter	79
Coronary Arterial Spasm During Pulsed Field Ablation to Treat Atrial Fibrillation	79
High-Density Lipoprotein Anti-Inflammatory Capacity and Incident Cardiovascular Events	79
Transcatheter Aortic Valve Implantation Represents an Anti-Inflammatory Therapy Via Reduction of Shear Stress–Induced, Piezo-1–Mediated Monocyte Activation	79
Cardiovascular Toxicities Associated With Hydroxychloroquine and Azithromycin	78
Human Engineered Heart Tissue Patches Remuscularize the Injured Heart in a Dose-Dependent Manner	78
Malonate Promotes Adult Cardiomyocyte Proliferation and Heart Regeneration	78
Initial Invasive Versus Conservative Management of Stable Ischemic Heart Disease in Patients With a History of Heart Failure or Left Ventricular Dysfunction	78
MicroRNA-21–Dependent Macrophage-to-Fibroblast Signaling Determines the Cardiac Response to Pressure Overload	77
Long Noncoding RNA Cardiac Physiological Hypertrophy–Associated Regulator Induces Cardiac Physiological Hypertrophy and Promotes Functional Recovery After Myocardial Ischemia-Reperfusion Injury	77
American Heart Association’s Life’s Simple 7: Lifestyle Recommendations, Polygenic Risk, and Lifetime Risk of Coronary Heart Disease	77
HDAC Inhibition Reverses Preexisting Diastolic Dysfunction and Blocks Covert Extracellular Matrix Remodeling	76
Chimeric Antigen Receptor T-Cell Therapy–Associated Cardiomyopathy in Patients With Refractory or Relapsed Non-Hodgkin Lymphoma	76
MDM2-Mediated Ubiquitination of Angiotensin-Converting Enzyme 2 Contributes to the Development of Pulmonary Arterial Hypertension	76
First-Line Catheter Ablation of Monomorphic Ventricular Tachycardia in Cardiomyopathy Concurrent With Defibrillator Implantation: The PAUSE-SCD Randomized Trial	75
Genetic and Phenotypic Landscape of Peripartum Cardiomyopathy	75
Linear and Nonlinear Mendelian Randomization Analyses of the Association Between Diastolic Blood Pressure and Cardiovascular Events	75
Atrial Fibrillation and Dementia: A Report From the AF-SCREEN International Collaboration	75
Excessive O -GlcNAcylation Causes Heart Failure and Sudden Death	74
Addition of Corticosteroids to Immunoglobulins Is Associated With Recovery of Cardiac Function in Multi-Inflammatory Syndrome in Children	74
Comparison Between Ticagrelor and Clopidogrel in Elderly Patients With an Acute Coronary Syndrome	74
Validating QT-Interval Measurement Using the Apple Watch ECG to Enable Remote Monitoring During the COVID-19 Pandemic	74
Randomized Ablation-Based Rhythm-Control Versus Rate-Control Trial in Patients With Heart Failure and Atrial Fibrillation: Results from the RAFT-AF trial	73
Metabolic Architecture of Acute Exercise Response in Middle-Aged Adults in the Community	73
Education, Implementation, and Teams: 2020 International Consensus on Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Science With Treatment Recommendations	73
Racial and Ethnic Disparities in Heart and Cerebrovascular Disease Deaths During the COVID-19 Pandemic in the United States	73
Branched-Chain Amino Acid Catabolism Promotes Thrombosis Risk by Enhancing Tropomodulin-3 Propionylation in Platelets	73
Mapping the Endothelial Cell S -Sulfhydrome Highlights the Crucial Role of Integrin Sulfhydration in Vascular Function	72
Adherence to a Healthy Sleep Pattern and Incident Heart Failure	72
Exercise Stress Real-Time Cardiac Magnetic Resonance Imaging for Noninvasive Characterization of Heart Failure With Preserved Ejection Fraction	72
Glucagon-Like Peptide 1 Receptor Agonists and Heart Failure	71
Perioperative Neurological Evaluation and Management to Lower the Risk of Acute Stroke in Patients Undergoing Noncardiac, Nonneurological Surgery: A Scientific Statement From the American Heart Associ	71
Evidence-Based Medical Therapy in Patients With Heart Failure With Reduced Ejection Fraction and Chronic Kidney Disease	71
Effect of Denosumab or Alendronic Acid on the Progression of Aortic Stenosis: A Double-Blind Randomized Controlled Trial	71